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Visceral adiposity

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https://www.readbyqxmd.com/read/28644850/visceral-adiposity-index-predicts-the-conversion-of-metabolically-healthy-obesity-to-an-unhealthy-phenotype
#1
Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim
OBJECTIVE: Some individuals with metabolically healthy obesity (MHO) convert to metabolically unhealthy obesity (MUO) phenotype, and visceral adiposity is one of proposed mechanisms underlying such conversion. Visceral adipose index (VAI) is a novel mathematical model which estimates visceral adiposity based on anthropometric and lipid profiles. We aimed to determine the association of VAI-estimated visceral adiposity with the MHO-to-MUO conversion and the predictive value of VAI in estimating such unfavorable outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28643028/polycystic-ovary-syndrome-adipose-tissue-and-metabolic-syndrome
#2
REVIEW
Alessandro P Delitala, Giampiero Capobianco, Giuseppe Delitala, Pier Luigi Cherchi, Salvatore Dessole
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). METHODS: A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome...
June 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28642810/association-of-the-composite-inflammatory-biomarker-glyca-with-exercise-induced-changes-in-body-habitus-in-men-and-women-with-prediabetes
#3
David B Bartlett, Cris A Slentz, Margery A Connelly, Lucy W Piner, Leslie H Willis, Lori A Bateman, Esther O Granville, Connie W Bales, Kim M Huffman, William E Kraus
GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes. GlycA, fitness, and body habitus were measured in 169 sedentary adults (45-75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28640481/using-analytic-morphomics-to-describe-body-composition-associated-with-post-kidney-transplantation-diabetes-mellitus
#4
David C Cron, Kelly A Noon, Devan R Cote, Michael N Terjimanian, Joshua J Augustine, Stewart C Wang, Michael J Englesbe, Kenneth J Woodside
BACKGROUND: Better risk assessment tools are needed to predict post-transplantation diabetes mellitus (PTDM). Using analytic morphomic measurements from computed tomography (CT) scans, we aimed to identify specific measures of body composition associated with PTDM. METHODS: We retrospectively reviewed 99 non-diabetic kidney transplant recipients who received pre-transplant CT scans at a single institution between 1/2005 and 5/2014. Analytic morphomic techniques were used to measure abdominal adiposity, abdominal size, and psoas muscle area and density, standardized by gender...
June 22, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28640441/adipose-tissue-derived-omentin-1-function-and-regulation
#5
Takuya Watanabe, Kaho Watanabe-Kominato, Yui Takahashi, Miho Kojima, Rena Watanabe
Omentin-1, also known as intelectin-1, is a recently identified novel adipocytokine of 313 amino acids, which is expressed in visceral (omental and epicardial) fat as well as mesothelial cells, vascular cells, airway goblet cells, small intestine, colon, ovary, and plasma. The level of omentin-1 expression in (pre)adipocytes is decreased by glucose/insulin and stimulated by fibroblast growth factor-21 and dexamethasone. Several lines of experimental evidence have shown that omentin-1 plays crucial roles in the maintenance of body metabolism and insulin sensitivity, and has anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects via AMP-activated protein kinase/Akt/nuclear factor-κB/mitogen-activated protein kinase (ERK, JNK, and p38) signaling...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28640092/glucose-metabolism-of-visceral-adipose-tissue-measured-by-18f-fdg-pet-ct-is-related-to-the-presence-of-colonic-adenoma
#6
Hai-Jeon Yoon, Bom Sahn Kim, Ko Eun Lee, Chang Mo Moon, Jang Yoo, Jung-Sook Kim, Yemi Kim
This study investigated the relationships between the area and metabolic activity of adipose tissue and the presence of colorectal adenoma (CRA). Our institutional review board approved the study and waived informed consent. A total of 212 subjects who underwent fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and colonoscopy for routine health check-ups were enrolled. The volumetric parameters of areas of visceral (VATav), subcutaneous (SATav), and total adipose tissue (TATav) and calculated visceral-to-subcutaneous adipose tissue ratio (VSR) and visceral-to-total adipose tissue ratio (VAR) were considered...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638930/-different-adipose-tissue-depots-and-metabolic-syndrome-in-human
#7
Ran Wang, Xiao-Nan Li
Obesity is characterized by abnormal and excessive adipose tissue accumulated in the body. Compared with peripheral obesity (the accumulation of subcutaneous adipose tissue), abdominal obesity (the accumulation of visceral adipose tissue) is associated with increased risk of the metabolic syndrome, such as diabetes, hypertension, atherosclerosis, and dyslipidemia. Adipose tissue is a highly heterogeneous endocrine organ. Adipose tissue depots differ significantly in anatomy, cell biology, glucose and lipid metabolism as well as in endocrine regulation...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28636750/comparison-of-serum-vaspin-levels-and-vaspin-expression-in-adipose-tissue-and-smooth-muscle-tissue-in-pregnant-women-with-and-without-gestational-diabetes
#8
Yuping Tang, Ping Qiao, Xiaoxian Qu, Yirong Bao, Yuhong Li, Yini Liao, Hao Ying
OBJECTIVE: Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains unclear. This study aimed to compare circulating vaspin levels and its expression in different insulin target tissues including subcutaneous adipose tissue (SAT), VAT, and smooth muscle tissue (SMT) in pregnant women with and without GDM...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28635909/-chronic-obstructive-pulmonary-disease-concurrent-with-metabolic-syndrome-pathophysiological-and-clinical-features
#9
A V Budnevsky, E S Ovsyannikov, N B Labzhania
Chronic obstructive pulmonary disease (COPD) still remains a serious public health problem, which is a common cause of disability and death in the able-bodied population. Furthermore, the number of patients with metabolic syndrome (MS) is steadily increasing worldwide. Recently, there is also an increase in the number of patients with COPD concurrent with MS, which is a mutually confounding risk factor for concomitant cardiovascular disease and adversely affects prognosis in these patients. Systemic subclinical inflammation is a common link between COPD and the components of MS...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28634585/high-plasma-glucagon-levels-correlate-with-waist-to-hip-ratio-suprailiac-skinfold-thickness-and-deep-subcutaneous-abdominal-and-intraperitoneal-adipose-tissue-depots-in-nonobese-asian-indian-males-with-type-2-diabetes-in-north-india
#10
Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Harsh Mahajan, Gokulraj Prabakaran
We aimed to correlate plasma glucagon levels with anthropometric measures and abdominal adipose tissue depots. Nonobese males (n = 81; BMI < 25 kg/m(2)) with T2DM of less than one-year duration and nonobese males without diabetes (n = 30) were evaluated for the following: anthropometry (BMI, waist circumference, W-HR, and truncal skinfolds), whole-body DEXA (for body fat and fat-free mass), and MRI scan (for volumes of subcutaneous abdominal adipose tissue (SCAT) including superficial and deep, intra-abdominal visceral adipose tissue (including intraperitoneal adipose tissue (IPAT), retroperitoneal adipose tissue, liver span and fatty liver, and pancreatic volume))...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28632304/are-visceral-adiposity-index-and-lipid-accumulation-product-reliable-indices-for-metabolic-disturbances-in-patients-with-type-2-diabetes-mellitus
#11
Nebojsa Kavaric, Aleksandra Klisic, Ana Ninic
BACKGROUND: Visceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). METHODS: A total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled...
June 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28629772/impact-of-the-cardiovascular-system-associated-adipose-tissue-on-atherosclerotic-pathology
#12
REVIEW
Dimitry A Chistiakov, Andrey V Grechko, Veronika A Myasoedova, Alexandra A Melnichenko, Alexander N Orekhov
Cardiac obesity makes an important contribution to the pathogenesis of cardiovascular disease. One of the important pathways of this contribution is the inflammatory process that takes place in the adipose tissue. In this review, we consider the role of the cardiovascular system-associated fat in atherosclerotic cardiovascular pathology and a non-atherosclerotic cause of coronary artery disease, such as atrial fibrillation. Cardiovascular system-associated fat not only serves as the energy store, but also releases adipokines that control local and systemic metabolism, heart/vascular function and vessel tone, and a number of vasodilating and anti-inflammatory substances...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28628145/-relationship-between-glycemic-control-and-visceral-adiposity-index-among-the-patients-with-type-2-diabetes-mellitus
#13
Y Y Cao, X Tang, K X Sun, Z K Liu, X Xiang, J Juan, J Song, Q Z Duan, D J Zhaxi, Y N Hu, Y F Yang, M Y Shi, Y H Tian, S P Huang, X F Liu, N Li, J Li, T Wu, D F Chen, Y H Hu
OBJECTIVE: To explore the relationship between glycemic control and visceral adiposity index (VAI) among type 2 diabetes mellitus (T2DM) patients. METHODS: A community-based epidemiological field study for patients with T2DM aged ≥ 40 years was conducted in China.Every participant underwent physical examinations, biochemical tests of fasting glucose, glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and so on, and a questionnaire, including anthropometric characteristics, lifestyle, disease history, family history, and medication use...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28626064/monitoring-c3ar-expression-using-a-floxed-tdtomato-c3ar-reporter-knock-in-mouse
#14
Katharina M Quell, Christian M Karsten, Anna Kordowski, Larissa Nogueira Almeida, Daria Briukhovetska, Anna V Wiese, Jing Sun, Fanny Ender, Konstantina Antoniou, Torsten Schröder, Inken Schmudde, Johann L Berger, Peter König, Tillman Vollbrandt, Yves Laumonnier, Jörg Köhl
C3a exerts multiple biologic functions through activation of its cognate C3a receptor. C3(-/-) and C3aR(-/-) mice have been instrumental in defining important roles of the C3a/C3aR axis in the regulation of acute and chronic inflammatory diseases, including ischemia/reperfusion injury, allergic asthma, autoimmune nephritis, and rheumatoid arthritis. Surprisingly little is known about C3aR expression and function in immune and stromal cells. To close this gap, we generated a floxed tandem-dye Tomato (tdTomato)-C3aR reporter knock-in mouse, which we used to monitor C3aR expression in cells residing in the lung, airways, lamina propria (LP) of the small intestine, brain, visceral adipose tissue, bone marrow (BM), spleen, and the circulation...
June 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28624865/bone-marrow-fat-contributes-to-insulin-sensitivity-and-adiponectin-secretion-in-premenopausal-women
#15
Federica Ermetici, Silvia Briganti, Alessandra Delnevo, Paola Cannaò, Giovanni Di Leo, Stefano Benedini, Ileana Terruzzi, Francesco Sardanelli, Livio Luzi
PURPOSE: Bone marrow fat is a functionally distinct adipose tissue that may contribute to systemic metabolism. This study aimed at evaluating a possible association between bone marrow fat and insulin sensitivity indices. METHODS: Fifty obese (n = 23) and non-obese (n = 27) premenopausal women underwent proton magnetic resonance spectroscopy to measure vertebral bone marrow fat content and unsaturation index at L4 level. Abdominal visceral, subcutaneous fat, and epicardial fat were also measured using magnetic resonance imaging...
June 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28624818/maternal-subcutaneous-and-visceral-adipose-ultrasound-thickness-in-women-with-gestational-diabetes-mellitus-at-24-28-weeks-gestation
#16
Francesco D'Ambrosi, Francesca Crovetto, Enrico Colosi, Isabella Fabietti, Floriana Carbone, Beatrice Tassis, Silvia Motta, Alessandro Bulfoni, Luigi Fedele, Gabriele Rossi, Nicola Persico
OBJECTIVE: To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies. METHODS: Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM. RESULTS: The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28623445/laparoscopic-sleeve-gastrectomy-resolves-low-ghrp-2-stimulated-growth-hormone-levels-in-obese-patients
#17
Emi Ohara, Hirotake Tokuyama, Takumi Kitamoto, Aya Kitahara, Aiko Hayashi, Hideki Hayashi, Minoru Takemoto, Koutaro Yokote
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 ± 9.4 kg/m(2)]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0...
June 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28622956/obesity-visceral-adipose-tissue-and-cognitive-function-in-childhood
#18
Lauren B Raine, Naiman A Khan, Eric S Drollette, Matthew B Pontifex, Arthur F Kramer, Charles H Hillman
OBJECTIVES: To evaluate the effects of a 9-month physical activity intervention on changes in adiposity and cognitive control based on pretrial weight status (ie, healthy weight vs obese) in children. STUDY DESIGN: Participants included obese (n = 77) and matched healthy-weight (n = 77) preadolescents (8-9 years) who participated in a 9-month physical activity randomized controlled trial. Cognitive function was assessed with an inhibitory control task (modified flanker task)...
June 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28616806/ipragliflozin-reduces-epicardial-fat-accumulation-in-non-obese-type-2-diabetic-patients-with-visceral-obesity-a-pilot-study
#19
Tatsuya Fukuda, Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
INTRODUCTION: Epicardial fat (EF) was reported to be independently associated with cardiovascular disease regardless of obesity. We have previously reported that a sodium-glucose co-transporter-2 (SGLT2) inhibitor, luseogliflozin, reduces the EF volume (EFV) in parallel with the reduction of body weight in obese patients (BMI ≥25 kg/m(2)) with type 2 diabetes. However, it is unknown whether SGLT2 inhibitors could reduce EFV in non-obese patients (BMI <25 kg/m(2)) with type 2 diabetes...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28615704/the-early-metabolomic-response-of-adipose-tissue-during-acute-cold-exposure-in-mice
#20
Xiyuan Lu, Ashley Solmonson, Alessia Lodi, Sara M Nowinski, Enrique Sentandreu, Christopher L Riley, Edward M Mills, Stefano Tiziani
To maintain core body temperature in cold conditions, mammals activate a complex multi-organ metabolic response for heat production. White adipose tissue (WAT) primarily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold exposure to generate heat from nutrients. Both BAT and WAT undergo specific metabolic changes during acute cold exposure. Here, we use an untargeted metabolomics approach to characterize the initial metabolic response to cold exposure in multiple adipose tissue depots in mice...
June 14, 2017: Scientific Reports
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