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https://www.readbyqxmd.com/read/27867509/comparison-of-fentanyl-iontophoretic-transdermal-system-and-routine-care-with-morphine-intravenous-patient-controlled-analgesia-in-the-management-of-early-postoperative-mobilisation-results-from-a-randomised-study
#1
Richard M Langford, Kuang-Yi Chang, Li Ding, Jeffrey Abraham
INTRODUCTION: Fentanyl iontophoretic transdermal system (ITS) (IONSYS(®), The Medicines Company, Parsippany, NJ, USA) and morphine intravenous (IV) patient-controlled analgesia (PCA) have demonstrated equivalent pain control in several published studies. The primary objective of the current study was to compare fentanyl ITS with morphine IV PCA with regard to the patient's ability to mobilise with acute postoperative pain. METHODS: In this multicentre, open-label, randomised, active-controlled, prospective phase IV study, postoperative patients initially received IV morphine and were titrated to pain score ⩽ 4out of 10 on a Numeric Rating Scale (NRS) and then received fentanyl ITS (up to 240 µg (6 doses)/hour; up to a maximum of 3...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27817153/use-of-fentanyl-iontophoretic-transdermal-system-its-ionsys-%C3%A2-in-the-management-of-patients-with-acute-postoperative-pain-a-case-series
#2
Steven Poplawski, Matthew Johnson, Philip Philips, Leopold H J Eberhart, Tilo Koch, Loretta M Itri
Fentanyl iontophoretic transdermal system (ITS) [IONSYS(®), The Medicines Company, Parsippany, NJ, USA] is a needle-free, patient-controlled, postoperative opioid pain management treatment. It is indicated for the short-term management of acute postoperative pain in adults requiring opioid analgesia in the hospital. The safety and effectiveness of fentanyl ITS for acute postoperative pain management has been demonstrated in a range of surgery and patient types studied in seven phase 3 trials (three placebo-controlled trials and four active-comparator trials)...
December 2016: Pain and Therapy
https://www.readbyqxmd.com/read/27785733/the-efficacy-and-safety-of-the-fentanyl-iontophoretic-transdermal-system-ionsys-%C3%A2-in-the-geriatric-population-results-of-a-meta-analysis-of-phase%C3%A2-iii-and-iiib-trials
#3
Eugene R Viscusi, Li Ding, Loretta M Itri
BACKGROUND AND OBJECTIVES: Acute postoperative pain management in the geriatric patient can be challenging, including their response to medications. The purpose of this analysis was to evaluate whether the efficacy and safety profile of fentanyl iontophoretic transdermal system (ITS) (IONSYS(®)) was similar in geriatric (≥65 years) and non-geriatric (<65 years) patients. METHODS: Efficacy and safety data from three randomized, double-blind, placebo-controlled trials and four randomized, open-label, active-comparator trials were utilized for this analysis...
October 27, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27442803/ease-of-care-from-the-physical-therapists-perspective-comparing-fentanyl-iontophoretic-transdermal-system-versus-morphine-intravenous-patient-controlled-analgesia-in-postoperative-pain-management
#4
Craig T Hartrick, Jeffrey Abraham, Li Ding
AIM: To compare the ease-of-care (EOC) examining time efficiency, convenience and satisfaction of fentanyl iontophoretic transdermal system ([ITS] IONSYS(®)) and morphine intravenous patient-controlled analgesia (iv. PCA) in postoperative pain management using a validated physical therapist (PT) EOC questionnaire. MATERIALS & METHODS: This meta-analysis assessed EOC of fentanyl ITS versus morphine iv. PCA using data from two randomized, active-comparator studies (fentanyl ITS: n = 720 and morphine iv...
November 2016: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27423647/fentanyl-iontophoretic-transdermal-system-ionsys-%C3%A2-can-be-safely-used-in-the-hospital-environment-with-x-rays-computerized-tomography-and-radiofrequency-identification-devices
#5
John Lemke, Edmond Sardariani, Joseph Bradley Phipps, Niki Patel, Loretta M Itri, James Caravelli, Eugene R Viscusi
INTRODUCTION: Fentanyl iontophoretic transdermal system (fentanyl ITS, IONSYS(®)) is a patient-controlled analgesia system used for the management of acute postoperative pain, designed to be utilized in a hospital setting. The objective of the two studies was to determine if fentanyl ITS could be safely used with X-rays, computerized tomography (CT) scans and radiofrequency identification (RFID) devices. METHODS: The ITS system has two components: controller and drug unit; the studies utilized ITS systems without fentanyl, referred to as the ITS Placebo system...
September 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27206564/patient-controlled-fentanyl-iontophoretic-transdermal-system-improved-postoperative-mobility-compared-to-intravenous-patient-controlled-analgesia-morphine-a-pooled-analysis-of-randomized-controlled-trials
#6
Ali Oliasharizi, Timothy Wilson-Byrne, Franklin D Shuler, Javad Parvizi
BACKGROUND: Postoperative pain management protocols that use patient-controlled analgesia (PCA) can hinder mobility due to attached machinery and tubing. Immobility in the postoperative setting can increase complications, length of stay (LOS), and costs. Early and enhanced mobilization can reduce the cost of care while improving patient outcomes. A needle-free, compact, patient-activated, and portable fentanyl iontophoretic transdermal system (fentanyl ITS, IONSYS; The Medicines Company, Parsippany NJ) has been shown to provide comparable efficacy and tolerability to intravenous (IV) PCA morphine that promotes improved mobility...
May 21, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/26968174/fentanyl-iontophoretic-transdermal-system-a-review-in-acute-postoperative-pain
#7
Lesley J Scott
Fentanyl iontophoretic transdermal system (ITS) [Ionsys(®)] is indicated for the management of acute postoperative pain in adults requiring opioid analgesia in the hospital setting. This article reviews the clinical use of fentanyl ITS for postoperative pain management, and summarizes the pharmacology of fentanyl and the characteristics of the two-component fentanyl ITS (Ionsys(®)) device. In well-designed, multicentre clinical trials, fentanyl ITS was an effective and generally well tolerated method for managing acute postoperative pain in inpatients who had undergone major abdominal, thoracic or orthopaedic surgery...
April 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/26529135/transdermal-fentanyl-ionsys-for-postoperative-pain
#8
(no author information available yet)
No abstract text is available yet for this article.
November 9, 2015: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/17164395/fentanyl-hcl-patient-controlled-iontophoretic-transdermal-system-for-the-management-of-acute-postoperative-pain
#9
REVIEW
Stacey Mayes, Marcus Ferrone
OBJECTIVE: To summarize the pharmaceutics, pharmacokinetics, development, and clinical application of IONSYS, the fentanyl HCl patient-controlled iontophoretic transdermal system for the management of acute postoperative pain. DATA SOURCES: Clinical literature including both primary sources and review articles was accessed through a search of the MEDLINE databases (1980-October 2006). Key search terms included cutaneous analgesia, fentanyl, IONSYS, opioid, postoperative pain, and patient-controlled analgesia (PCA)...
December 2006: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/16156110/the-fentanyl-hcl-patient-controlled-transdermal-system-pcts-an-alternative-to-intravenous-patient-controlled-analgesia-in-the-postoperative-setting
#10
REVIEW
Raymond Sinatra
Inadequate pain control in the postoperative period not only contributes to patient discomfort, but also causes physiological changes that may result in increased risk of myocardial ischaemia, deep vein thrombosis and pulmonary embolism. These events complicate postoperative recovery and may lead to longer hospital stays as well as increased healthcare costs. Patient-controlled analgesia (PCA) has emerged as an effective way for patients to manage their pain, allowing self-administration of small doses of analgesics to maintain a certain level of pain control...
2005: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/16102706/patient-controlled-modalities-for-acute-postoperative-pain-management
#11
REVIEW
Christine Miaskowski
Although numerous clinical practice guidelines for pain management have been published throughout the last 12 years, inadequate pain relief remains a significant health care issue. Several patient-controlled analgesia (PCA) modalities are currently available for the treatment of acute postoperative pain, including intravenous (IV) PCA, epidural (PCEA), and oral PCA. Although PCEA and IV PCA are both commonly used modalities, IV PCA is considered the standard of care for postoperative pain management. Limitations of this modality do exist, however...
August 2005: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
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