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https://www.readbyqxmd.com/read/29720500/xanthine-oxidase-inhibitor-allopurinol-prevents-oxidative-stress-mediated-atrial-remodeling-in-alloxan-induced-diabetes-mellitus-rabbits
#1
Yajuan Yang, Jianping Zhao, Jiuchun Qiu, Jian Li, Xue Liang, Zhiwei Zhang, Xiaowei Zhang, Huaying Fu, Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Guangping Li, Tong Liu
BACKGROUND: There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relationship between oxidative stress and atrial electrical and structural remodeling, and calcium handling abnormalities, and the potential beneficial effects of the xanthine oxidase inhibitor allopurinol upon these pathological changes...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29657587/impact-of-ranolazine-on-ventricular-arrhythmias-a-systematic-review
#2
REVIEW
George Bazoukis, Gary Tse, Konstantinos P Letsas, Costas Thomopoulos, Katerina K Naka, Panagiotis Korantzopoulos, Xenophon Bazoukis, Paschalia Michelongona, Stamatis S Papadatos, Konstantinos Vlachos, Tong Liu, Michael Efremidis, Adrian Baranchuk, Stavros Stavrakis, Costas Tsioufis
Ranolazine is a new medication for the treatment of refractory angina. However, except its anti-anginal properties, it has been found to act as an anti-arrhythmic. The aim of our systematic review is to present the existing data about the impact of ranolazine in ventricular arrhythmias. We searched MEDLINE and Cochrane databases as well clinicaltrials.gov until September 1, 2017 to find all studies (clinical trials, observational studies, case reports/series) reported data about the impact of ranolazine in ventricular arrhythmias...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29600088/the-j-waves-of-hypothermia
#3
EDITORIAL
Panagiotis Mililis, George Bazoukis, Athanasios Bakalakos, Konstantinos P Letsas
Prominent J-waves are observed in several clinical conditions many of which are highly arrhythmogenic and may lead to ventricular fibrillation (VF) and/or sudden cardiac death. We present the case of a 34-year-old male patient with hypothermia. Prominent J-waves (Osborn waves) and prolonged QT interval was evident in nearly every lead. Early recognition of these arrhythmogenic electrocardiogram (ECG) findings and treatment of hypothermia is important to minimize the risk of arrhythmic events.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29581718/meta-analysis-of-t-wave-indices-for-risk-stratification-in-myocardial-infarction
#4
Gary Tse, Cheuk Wai Wong, Meng-Qi Gong, Lei Meng, Konstantinos P Letsas, Guang-Ping Li, Paula Whittaker, Aishwarya Bhardwaj, Abhishek C Sawant, William Kk Wu, Sunny Hei Wong, Jayaprakash Shenthar, Lap Ah Tse, Martin Cs Wong, Adrian Baranchuk, Gan-Xin Yan, Tong Liu
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29550106/meta-analysis-of-t-peak-t-end-and-t-peak-t-end-qt-ratio-for-risk-stratification-in-congenital-long-qt-syndrome
#5
Gary Tse, Mengqi Gong, Lei Meng, Cheuk Wai Wong, Stamatis Georgopoulos, George Bazoukis, Martin C S Wong, Konstantinos P Letsas, Vassilios S Vassiliou, Yunlong Xia, Adrian M Baranchuk, Gan-Xin Yan, Tong Liu
BACKGROUND AND OBJECTIVES: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak -Tend interval and the Tpeak -Tend /QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak -Tend intervals and Tpeak -Tend /QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS...
May 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29468258/intermuscular-implantation-technique-for-subcutaneous-cardioverter-defibrillators
#6
K P Letsas, S Xydonas, N Karamichalakis, M Efremidis, D Manolatos, G Bazoukis, D Asvestas, K Vlachos, S Georgopoulos, A Saplaouras, J Winter, A Sideris
BACKGROUND: The conventional technique for subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation has been associated with pocket complications. The aim of this study was to evaluate the efficacy and safety of an alternative intermuscular technique for S‑ICD implantation. METHODS: S-ICDs were implanted in ten consecutive patients (ten males, mean age: 46.8 ± 14.7 years). The pocket for the pulse generator was made above the serratus anterior muscular fascia and beneath the latissimus dorsi muscle by detaching the fibrous tissue between the muscles...
February 21, 2018: Herz
https://www.readbyqxmd.com/read/29356016/predictors-of-arrhythmia-recurrence-in-patients-with-heart-failure-undergoing-left-atrial-ablation-for-atrial-fibrillation
#7
George Bazoukis, Konstantinos P Letsas, Gary Tse, Katerina K Naka, Panagiotis Korantzopoulos, Evangelia Ntzani, Konstantinos Vlachos, Athanasios Saplaouras, Eirini Pagkalidou, Lampros K Michalis, Antonios Sideris, Michael Efremidis
BACKGROUND: Atrial fibrillation (AF) ablation is increasingly used in patients with reduced left ventricular ejection fraction (LVEF). The aim of the present study was to evaluate the long-term results of a single radiofrequency catheter ablation procedure in heart failure (HF) patients with AF. HYPOTHESIS: We tested the hypothesis that left atrial ablation is an effective therapeutic modality in patients with heart failure. METHODS: Our study included HF patients with LVEF <50% who underwent catheter ablation for AF at our department between January 2010 and March 2017...
January 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29315856/red-blood-cell-distribution-width-as-a-predictor-of-atrial-fibrillation
#8
Qingmiao Shao, Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Jiang Hong, Guangping Li, Tong Liu
BACKGROUND: Current evidence suggests that a higher red blood cell distribution width (RDW) may be associated with increased risk of atrial fibrillation (AF) development. Given that some controversial results have been published, we conducted a systematic review of the current literature along with a comprehensive meta-analysis to evaluate the association between RDW and AF development. METHODS: We performed a systematic search of the literature using electronic databases (PubMed, Ovid, Embase, and Web of Science) to identify studies reporting on the association between RDW and AF development published until June 2016...
January 8, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29238365/spontaneous-type-1-pattern-ventricular-arrhythmias-and-sudden-cardiac-death-in-brugada-syndrome-an-updated-systematic-review-and-meta-analysis
#9
Ahmed Bayoumy, Meng-Qi Gong, Ka Hou Christien Li, Sunny Hei Wong, William Kk Wu, Guang-Ping Li, George Bazoukis, Konstantinos P Letsas, Wing Tak Wong, Yun-Long Xia, Tong Liu, Gary Tse
No abstract text is available yet for this article.
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29194518/coincidental-ganglionated-plexus-modification-during-radiofrequency-pulmonary-vein-isolation-and-post-ablation-arrhythmia-recurrence
#10
Georgios Giannopoulos, Charalampos Kossyvakis, Christos Angelidis, Vasiliki Panagopoulou, Dimitrios Tsiachris, Dimitrios A Vrachatis, Konstantinos Doudoumis, Konstantinos Letsas, Stamatina Pagoni, Christodoulos Stefanadis, Vassilios P Vassilikos, John Lekakis, Spyridon Deftereos
Aims: Vagal responses (VR) during left atrial ablation for atrial fibrillation (AF) treatment have been reported to be associated with less recurrences, presumably because they are a sign of ganglionated plexi modification. Our objective was to evaluate whether coincidentally elicited VR during left atrial ablation are associated with lower AF recurrence rates. Methods and results: This is a post hoc analysis of a prospective study of 291 patients with paroxysmal AF undergoing radiofrequency pulmonary vein isolation (PVI)...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29021843/impact-of-baseline-renal-function-on-all-cause-mortality-in-patients-who-underwent-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#11
REVIEW
G Bazoukis, K P Letsas, P Korantzopoulos, C Thomopoulos, K Vlachos, S Georgopoulos, N Karamichalakis, A Saplaouras, M Efremidis, A Sideris
BACKGROUND: Cardiac resynchronization therapy (CRT) improves both morbidity and mortality in selected patients with heart failure and increased QRS duration. However, chronic kidney disease (CKD) may have an adverse effect on patient outcome. The aim of this systematic review was to analyze the existing data regarding the impact of baseline renal function on all-cause mortality in patients who underwent CRT. METHODS: Medline database was searched systematically, and studies evaluating the effect of baseline renal function on all-cause mortality in patients who underwent CRT were retrieved...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28994463/prognosis-risk-stratification-and-management-of-asymptomatic-individuals-with-brugada-syndrome-a-systematic-review
#12
REVIEW
Konstantinos P Letsas, Dimitrios Asvestas, Adrian Baranchuk, Tong Liu, Stamatis Georgopoulos, Michael Efremidis, Panagiotis Korantzopoulos, George Bazoukis, Gary Tse, Antonios Sideris, Masahiko Takagi, Joachim R Ehrlich
Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter-defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life...
December 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28955245/meta-analysis-of-fragmented-qrs-as-an-electrocardiographic-predictor-for-arrhythmic-events-in-patients-with-brugada-syndrome
#13
Lei Meng, Konstantinos P Letsas, Adrian Baranchuk, Qingmiao Shao, Gary Tse, Nixiao Zhang, Zhiwei Zhang, Dan Hu, Guangping Li, Tong Liu
Fragmented QRS (fQRS) is an electrocardiographic marker related to ventricular fibrillation (VF) and sudden cardiac death (SCD) in various clinical settings. Current data regarding the prognostic significance of fQRS in Brugada syndrome (BrS) are contradictory. This meta-analysis aimed to evaluate the presence of fQRS as a risk stratification tool in BrS. Electronic databases (PubMed, EMBASE, and Cochrane Library) were searched until May 2016. Eight observational studies accumulating data on 1,637 BrS patients (mean age: 47 ± 11 years) were included in this meta-analysis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28901628/total-cosine-r-to-t-for-predicting-ventricular-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#14
Gary Tse, Mengqi Gong, Cheuk Wai Wong, Cynthia Chan, Stamatis Georgopoulos, Yat Sun Chan, Bryan P Yan, Guangping Li, Paula Whittaker, Ana Ciobanu, Sadeq Ali-Hasan-Al-Saegh, Sunny H Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Lap Ah Tse, Adrian M Baranchuk, Konstantinos P Letsas, Tong Liu
BACKGROUND: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28884923/low-voltage-areas-detected-by-high-density-electroanatomical-mapping-predict-recurrence-after-ablation-for-paroxysmal-atrial-fibrillation
#15
Konstantinos Vlachos, Michael Efremidis, Konstantinos P Letsas, George Bazoukis, Ruairidh Martin, Maria Kalafateli, Louiza Lioni, Stamatis Georgopoulos, Athanasios Saplaouras, Theodore Efremidis, Tong Liu, Kosmas Valkanas, Nikolaos Karamichalakis, Dimitrios Asvestas, Antonios Sideris
INTRODUCTION: We aimed to evaluate the extent of atrial fibrosis in paroxysmal atrial fibrillation (AF) and the correlation with ablation outcomes after pulmonary vein antral isolation (PVΑI) using a mapping system with high-resolution and high-spatial sampling. METHODS AND RESULTS: We prospectively enrolled 80 consecutive patients (45 males, median age 60.26 years) with symptomatic paroxysmal AF who were scheduled for PVAI. Prior to PVAI, high-density bipolar voltage mapping (median number of 2,485 points) was carried out during sinus rhythm in all patients...
December 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28797285/large-cholera-outbreak-in-brong-ahafo-region-ghana
#16
Charles Lwanga Noora, Kofi Issah, Ernest Kenu, Emmanuel George Bachan, Robert Domo Nuoh, Kofi Mensah Nyarko, Paulina Appiah, Timothy Letsa
BACKGROUND: A nationwide outbreak of Vibrio cholerae occurred in Ghana in 2014 with Accra, the nation's capital as the epi-center. The outbreak spread to the Brong Ahafo Region (BAR) which is geographically located in the middle of the country. In this region a review of data collected during the outbreak was carried out and analyzed descriptively to determine the hot spots and make recommendations for effective response to future outbreaks. METHODS: A review of patient records and line lists of cases of cholera reported in all hospitals during the period of the outbreak (July-December 2014) was conducted...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28765753/adenosine-guided-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-meta-analysis-of-randomized-control-trials
#17
REVIEW
Konstantinos P Letsas, Stamatis Georgopoulos, Michael Efremidis, Tong Liu, George Bazoukis, Konstantinos Vlachos, Nikolaos Karamichalakis, Louiza Lioni, Antonios Sideris, Joachim R Ehrlich
BACKGROUND: The prognostic significance of adenosine-mediated dormant pulmonary vein conduction, and whether such dormant conduction should be eliminated, remains controversial. We sought to perform a meta-analysis of data from eligible studies to delineate the prognostic impact of adenosine-guided radiofrequency catheter ablation of atrial fibrillation. METHODS: A systematic literature search was performed using online databases in order to identify relevant studies from January 2004 to September 2016...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28685653/impact-of-statin-therapy-on-all-cause-mortality-and-icd-interventions-in-heart-failure-patients-a-systematic-review
#18
George Bazoukis, Stamatis S Papadatos, Konstantinos P Letsas, Eirini Pagkalidou, Panagiotis Korantzopoulos
OBJECTIVES: Implantable cardioverter defibrillators (ICDs) have a unique role for the primary and secondary prevention of sudden cardiac death (SCD). The aim of our systematic review is to present the existing data about the impact of statins on all-cause mortality and ICD interventions in heart failure (HF) patients who had an ICD implanted either for primary or for secondary prevention of SCD. METHODS AND RESULTS: We searched PubMed database and the reference list of the relevant studies for retrieving studies evaluating the effect of statins on all-cause mortality and ICD interventions in HF patients...
October 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28679858/p-wave-indices-and-risk-of-ischemic-stroke-a-systematic-review-and-meta-analysis
#19
REVIEW
Jinli He, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P Letsas, Sadeq Ali-Hasan-Al-Saegh, Hooman Kamel, Guangping Li, Gregory Y H Lip, Tong Liu
BACKGROUND AND PURPOSE: Atrial cardiomyopathy is associated with an increased risk of ischemic stroke. P-wave terminal force in lead V1 , P-wave duration, and maximum P-wave area are electrocardiographic parameters that have been used to assess left atrial abnormalities related to developing atrial fibrillation. The aim of this systematic review and meta-analysis was to examine their values for predicting ischemic stroke risk. METHODS: PubMed and EMBASE databases were searched until December 2016 for studies that evaluated the association between P-wave indices and stroke risk...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28561951/safety-and-efficacy-of-doacs-vs-acenocoumarol-in-patients-undergoing-catheter-ablation-of-atrial-fibrillation
#20
Konstantinos Vlachos, Michael Efremidis, George Bazoukis, Konstantinos P Letsas, Athanasios Saplaouras, Stamatis Georgopoulos, Nikolaos Karamichalakis, Aikaterini Rokiza, Antigoni Sakellaropoulou, Angelos Michail Kolokathis, Theodoros Efremidis, Dimitrios Asvestas, Antonios Sideris
BACKGROUND: Thromboembolic complications can be life-threatening during atrial fibrillation (AF) catheter ablation. The aim of our study was to evaluate the safety and efficacy of continuous treatment using direct oral anticoagulants (DOACs) as an alternative to uninterrupted acenocoumarol for periprocedural anticoagulation. HYPOTHESIS: Continuous treatment with DOACs has similar safety and efficacy compared to acenocoumarol. METHODS: We enrolled 474 patients (mean age, 58 years; 68...
May 31, 2017: Clinical Cardiology
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