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https://www.readbyqxmd.com/read/29021843/impact-of-baseline-renal-function-on-all-cause-mortality-in-patients-who-underwent-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#1
REVIEW
G Bazoukis, K P Letsas, P Korantzopoulos, C Thomopoulos, K Vlachos, S Georgopoulos, N Karamichalakis, A Saplaouras, M Efremidis, A Sideris
BACKGROUND: Cardiac resynchronization therapy (CRT) improves both morbidity and mortality in selected patients with heart failure and increased QRS duration. However, chronic kidney disease (CKD) may have an adverse effect on patient outcome. The aim of this systematic review was to analyze the existing data regarding the impact of baseline renal function on all-cause mortality in patients who underwent CRT. METHODS: Medline database was searched systematically, and studies evaluating the effect of baseline renal function on all-cause mortality in patients who underwent CRT were retrieved...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28994463/prognosis-risk-stratification-and-management-of-asymptomatic-individuals-with-brugada-syndrome-a-systematic-review
#2
REVIEW
Konstantinos P Letsas, Dimitrios Asvestas, Adrian Baranchuk, Tong Liu, Stamatis Georgopoulos, Michael Efremidis, Panagiotis Korantzopoulos, George Bazoukis, Gary Tse, Antonios Sideris, Masahiko Takagi, Joachim R Ehrlich
Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28955245/meta-analysis-of-fragmented-qrs-as-an-electrocardiographic-predictor-for-arrhythmic-events-in-patients-with-brugada-syndrome
#3
Lei Meng, Konstantinos P Letsas, Adrian Baranchuk, Qingmiao Shao, Gary Tse, Nixiao Zhang, Zhiwei Zhang, Dan Hu, Guangping Li, Tong Liu
Fragmented QRS (fQRS) is an electrocardiographic marker related to ventricular fibrillation (VF) and sudden cardiac death (SCD) in various clinical settings. Current data regarding the prognostic significance of fQRS in Brugada syndrome (BrS) are contradictory. This meta-analysis aimed to evaluate the presence of fQRS as a risk stratification tool in BrS. Electronic databases (PubMed, EMBASE, and Cochrane Library) were searched until May 2016. Eight observational studies accumulating data on 1,637 BrS patients (mean age: 47 ± 11 years) were included in this meta-analysis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28901628/total-cosine-r-to-t-for-predicting-ventricular-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#4
Gary Tse, Mengqi Gong, Cheuk Wai Wong, Cynthia Chan, Stamatis Georgopoulos, Yat Sun Chan, Bryan P Yan, Guangping Li, Paula Whittaker, Ana Ciobanu, Sadeq Ali-Hasan-Al-Saegh, Sunny H Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Lap Ah Tse, Adrian M Baranchuk, Konstantinos P Letsas, Tong Liu
BACKGROUND: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28884923/low-voltage-areas-detected-by-high-density-electroanatomical-mapping-predict-recurrence-after-ablation-for-paroxysmal-atrial-fibrillation
#5
Konstantinos Vlachos, Michael Efremidis, Konstantinos P Letsas, George Bazoukis, Ruairidh Martin, Maria Kalafateli, Louiza Lioni, Stamatis Georgopoulos, Athanasios Saplaouras, Theodore Efremidis, Tong Liu, Kosmas Valkanas, Nikolaos Karamichalakis, Dimitrios Asvestas, Antonios Sideris
INTRODUCTION: We aimed to evaluate the extent of atrial fibrosis in paroxysmal atrial fibrillation (AF) and the correlation with ablation outcomes after pulmonary vein antral isolation (PVΑI) using a mapping system with high-resolution and high-spatial sampling. METHODS AND RESULTS: We prospectively enrolled 80 consecutive patients (45 males, median age 60.26 years) with symptomatic paroxysmal AF who were scheduled for PVAI. Prior to PVAI, high-density bipolar voltage mapping (median number of 2,485 points) was carried out during sinus rhythm in all patients...
September 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28797285/large-cholera-outbreak-in-brong-ahafo-region-ghana
#6
Charles Lwanga Noora, Kofi Issah, Ernest Kenu, Emmanuel George Bachan, Robert Domo Nuoh, Kofi Mensah Nyarko, Paulina Appiah, Timothy Letsa
BACKGROUND: A nationwide outbreak of Vibrio cholerae occurred in Ghana in 2014 with Accra, the nation's capital as the epi-center. The outbreak spread to the Brong Ahafo Region (BAR) which is geographically located in the middle of the country. In this region a review of data collected during the outbreak was carried out and analyzed descriptively to determine the hot spots and make recommendations for effective response to future outbreaks. METHODS: A review of patient records and line lists of cases of cholera reported in all hospitals during the period of the outbreak (July-December 2014) was conducted...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28765753/adenosine-guided-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-meta-analysis-of-randomized-control-trials
#7
REVIEW
Konstantinos P Letsas, Stamatis Georgopoulos, Michael Efremidis, Tong Liu, George Bazoukis, Konstantinos Vlachos, Nikolaos Karamichalakis, Louiza Lioni, Antonios Sideris, Joachim R Ehrlich
BACKGROUND: The prognostic significance of adenosine-mediated dormant pulmonary vein conduction, and whether such dormant conduction should be eliminated, remains controversial. We sought to perform a meta-analysis of data from eligible studies to delineate the prognostic impact of adenosine-guided radiofrequency catheter ablation of atrial fibrillation. METHODS: A systematic literature search was performed using online databases in order to identify relevant studies from January 2004 to September 2016...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28685653/impact-of-statin-therapy-on-all-cause-mortality-and-icd-interventions-in-heart-failure-patients-a-systematic-review
#8
George Bazoukis, Stamatis S Papadatos, Konstantinos P Letsas, Eirini Pagkalidou, Panagiotis Korantzopoulos
OBJECTIVES: Implantable cardioverter defibrillators (ICDs) have a unique role for the primary and secondary prevention of sudden cardiac death (SCD). The aim of our systematic review is to present the existing data about the impact of statins on all-cause mortality and ICD interventions in heart failure (HF) patients who had an ICD implanted either for primary or for secondary prevention of SCD. METHODS AND RESULTS: We searched PubMed database and the reference list of the relevant studies for retrieving studies evaluating the effect of statins on all-cause mortality and ICD interventions in HF patients...
July 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28679858/p-wave-indices-and-risk-of-ischemic-stroke-a-systematic-review-and-meta-analysis
#9
REVIEW
Jinli He, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P Letsas, Sadeq Ali-Hasan-Al-Saegh, Hooman Kamel, Guangping Li, Gregory Y H Lip, Tong Liu
BACKGROUND AND PURPOSE: Atrial cardiomyopathy is associated with an increased risk of ischemic stroke. P-wave terminal force in lead V1, P-wave duration, and maximum P-wave area are electrocardiographic parameters that have been used to assess left atrial abnormalities related to developing atrial fibrillation. The aim of this systematic review and meta-analysis was to examine their values for predicting ischemic stroke risk. METHODS: PubMed and EMBASE databases were searched until December 2016 for studies that evaluated the association between P-wave indices and stroke risk...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28561951/safety-and-efficacy-of-doacs-vs-acenocoumarol-in-patients-undergoing-catheter-ablation-of-atrial-fibrillation
#10
Konstantinos Vlachos, Michael Efremidis, George Bazoukis, Konstantinos P Letsas, Athanasios Saplaouras, Stamatis Georgopoulos, Nikolaos Karamichalakis, Aikaterini Rokiza, Antigoni Sakellaropoulou, Angelos Michail Kolokathis, Theodoros Efremidis, Dimitrios Asvestas, Antonios Sideris
BACKGROUND: Thromboembolic complications can be life-threatening during atrial fibrillation (AF) catheter ablation. The aim of our study was to evaluate the safety and efficacy of continuous treatment using direct oral anticoagulants (DOACs) as an alternative to uninterrupted acenocoumarol for periprocedural anticoagulation. HYPOTHESIS: Continuous treatment with DOACs has similar safety and efficacy compared to acenocoumarol. METHODS: We enrolled 474 patients (mean age, 58 years; 68...
May 31, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28552749/the-tpeak-tend-interval-as-an-electrocardiographic-risk-marker-of-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#11
Gary Tse, Mengqi Gong, Wing Tak Wong, Stamatis Georgopoulos, Konstantinos P Letsas, Vassilios S Vassiliou, Yat Sun Chan, Bryan P Yan, Sunny Hei Wong, William K K Wu, Ana Ciobanu, Guangping Li, Jayaprakash Shenthar, Ardan M Saguner, Sadeq Ali-Hasan-Al-Saegh, Aishwarya Bhardwaj, Abhishek C Sawant, Paula Whittaker, Yunlong Xia, Gan-Xin Yan, Tong Liu
BACKGROUND: The Tpeak - Tend interval (the interval from the peak to the end of the T wave), an electrocardiographic marker reflecting transmural dispersion of repolarization, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death in different clinical settings. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of the Tpeak - Tend interval in predicting arrhythmic and/or mortality end points. METHODS: PubMed, Embase, Cochrane Library, and CINAHL Plus databases were searched through November 30, 2016...
August 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28472282/right-ventricular-outflow-tract-high-density-endocardial-unipolar-voltage-mapping-in-patients-with-brugada-syndrome-evidence-for-electroanatomical-abnormalities
#12
Konstantinos P Letsas, Michael Efremidis, Konstantinos Vlachos, Stamatis Georgopoulos, Nikolaos Karamichalakis, Dimitrios Asvestas, Kosmas Valkanas, Panagiotis Korantzopoulos, Tong Liu, Antonios Sideris
Aims: Epicardial structural abnormalities at the right ventricular outflow tract (RVOT) may provide the arrhythmia substrate in Brugada syndrome (BrS). Electroanatomical endocardial unipolar voltage mapping is an emerging tool that accurately identifies epicardial abnormalities in different clinical settings. This study investigated whether endocardial unipolar voltage mapping of the RVOT detects electroanatomical abnormalities in patients with BrS. Methods and results: Ten asymptomatic patients (8 males, 34...
May 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28381265/thiazolidinedione-use-and-atrial-fibrillation-in-diabetic-patients-a-meta-analysis
#13
Zhiwei Zhang, Xiaowei Zhang, Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Mengqi Gong, Lei Meng, Guangping Li, Tong Liu
BACKGROUND: Accumulating evidence suggests that thiazolidinediones (TZDs) may exert protective effects in atrial fibrillation (AF). The present meta-analysis investigated the association between TZD use and the incidence of AF in diabetic patients. METHODS: Electronic databases were searched until December 2016. Of the 346 initially identified records, 3 randomized clinical trials (RCTs) and 4 observational studies with 130,854 diabetic patients were included in the final analysis...
April 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28267752/serum-glycated-hemoglobin-level-as-a-predictor-of-atrial-fibrillation-a-systematic-review-with-meta-analysis-and-meta-regression
#14
REVIEW
Wenwei Qi, Nixiao Zhang, Panagiotis Korantzopoulos, Konstantinos P Letsas, Min Cheng, Fusheng Di, Gary Tse, Tong Liu, Guangping Li
BACKGROUND AND AIM: Glycated hemoglobin (HbA1c) is a long-term measure of glucose control. Although recent studies demonstrated a potential association between HbA1c levels and the risk of atrial fibrillation (AF), the results have been inconsistent. The aim of this meta-analysis is to evaluate the utility of HbA1c level in predicting AF. METHODS: PubMed and the Cochrane Library databases were searched for relevant studies up to March 2016. Prospective cohort studies and retrospective case-control studies were included...
2017: PloS One
https://www.readbyqxmd.com/read/28089877/permanent-pacemaker-implantation-in-octogenarians-with-unexplained-syncope-and-positive-electrophysiologic-testing
#15
Georgios Giannopoulos, Charalampos Kossyvakis, Vasiliki Panagopoulou, Dimitrios Tsiachris, Konstantinos Doudoumis, Maria Mavri, Dimitrios Vrachatis, Konstantinos Letsas, Michael Efremidis, Apostolos Katsivas, John Lekakis, Spyridon Deftereos
BACKGROUND: Syncope is a common problem in the elderly, and a permanent pacemaker is a therapeutic option when a bradycardic etiology is revealed. However, the benefit of pacing when no association of symptoms to bradycardia has been shown is not clear, especially in the elderly. OBJECTIVE: The aim of this study was to evaluate the effect of pacing on syncope-free mortality in patients aged 80 years or older with unexplained syncope and "positive" invasive electrophysiologic testing (EPT)...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28087596/a-meta-analysis-on-the-prognostic-significance-of-inferolateral-early-repolarization-pattern-in-brugada-syndrome
#16
Stamatis Georgopoulos, Konstantinos P Letsas, Tong Liu, Maria Kalafateli, Panagiotis Korantzopoulos, Gerd Bürkle, Konstantinos Vlachos, Georgios Giannopoulos, Michael Efremidis, Spyridon Deftereos, Antonios Sideris, Masahiko Takagi, Gan-Xin Yan, Joachim R Ehrlich
AIMS: The early repolarization (ER) pattern has been linked to an increased risk for arrhythmic death in various clinical settings. There are limited and conflicting data regarding the prognostic significance of ER pattern in Brugada syndrome (BS). The aim of this meta-analysis was to provide a detailed analysis of the currently available studies regarding the arrhythmic risk in patients with BS and ER pattern. METHODS AND RESULTS: Current databases were searched until May 2015...
January 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27920827/catheter-ablation-of-anteroseptal-accessory-pathways-from-the-aortic-cusps-a-case-series-and-a-review-of-the-literature
#17
REVIEW
Konstantinos P Letsas, Michael Efremidis, Konstantinos Vlachos, Stamatis Georgopoulos, Nikolaos Karamichalakis, Athanasios Saplaouras, Sotirios Xydonas, Kosmas Valkanas, Antonios Sideris
Data regarding catheter ablation of anteroseptal accessory pathways through the aortic cusps are limited. We describe two cases of true para-Hisian accessory pathways successfully ablated from the aortic cusps (right coronary cusp and non-coronary cusp, respectively) along with a review of the current literature. Due to the close proximity to the atrioventricular node and the high risk of complication, mapping of the aortic cusps should always be considered in the case of anteroseptal accessory pathways. Anteroseptal accessory pathways can be safely and effectively ablated from the aortic cusps with good long-term outcomes...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27909531/brugada-syndrome-risk-stratification-and-management
#18
REVIEW
Konstantinos P Letsas, Stamatis Georgopoulos, Konstantinos Vlachos, Nikolaos Karamichalakis, Ioannis Liatakis, Panagiotis Korantzopoulos, Tong Liu, Michael Efremidis, Antonios Sideris
The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27781063/efficacy-and-safety-of-novel-anticoagulants-in-the-elderly
#19
REVIEW
Nikolaos Karamichalakis, Stamatis Georgopoulos, Konstantinos Vlachos, Ioannis Liatakis, Michael Efremidis, Antonios Sideris, Konstantinos P Letsas
Atrial fibrillation and venous thromboembolism (VTE) are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetics, often present in these patients, render the use of anticoagulants quite challenging. Novel oral anticoagulants (NOACs) have recently emerged as alternatives to Vitamin K Antagonists (VKAs) and are gradually increasing their popularity mainly because of their fewer drug and food interactions and ease of use...
August 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27756235/an-outbreak-of-pneumococcal-meningitis-among-older-children-%C3%A2-5%C3%A2-years-and-adults-after-the-implementation-of-an-infant-vaccination-programme-with-the-13-valent-pneumococcal-conjugate-vaccine-in-ghana
#20
Brenda Anna Kwambana-Adams, Franklin Asiedu-Bekoe, Badu Sarkodie, Osei Kuffour Afreh, George Khumalo Kuma, Godfred Owusu-Okyere, Ebenezer Foster-Nyarko, Sally-Ann Ohene, Charles Okot, Archibald Kwame Worwui, Catherine Okoi, Madikay Senghore, Jacob Kweku Otu, Chinelo Ebruke, Richard Bannerman, Kwame Amponsa-Achiano, David Opare, Gemma Kay, Timothy Letsa, Owen Kaluwa, Ebenezer Appiah-Denkyira, Victor Bampoe, Syed M A Zaman, Mark J Pallen, Umberto D'Alessandro, Jason M Mwenda, Martin Antonio
BACKGROUND: An outbreak of pneumococcal meningitis among non-infant children and adults occurred in the Brong-Ahafo region of Ghana between December 2015 and April 2016 despite the recent nationwide implementation of a vaccination programme for infants with the 13-valent pneumococcal conjugate vaccine (PCV13). METHODS: Cerebrospinal fluid (CSF) specimens were collected from patients with suspected meningitis in the Brong-Ahafo region. CSF specimens were subjected to Gram staining, culture and rapid antigen testing...
October 18, 2016: BMC Infectious Diseases
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