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https://www.readbyqxmd.com/read/27933755/maternal-pre-pregnancy-bmi-downregulates-neonatal-cord-blood-lep-methylation
#1
R Kadakia, Y Zheng, Z Zhang, W Zhang, L Hou, J L Josefson
BACKGROUND: Neonatal adiposity has many determinants and may be a risk factor for future obesity. Epigenetic regulation of metabolically important genes is a potential contributor. OBJECTIVES: The objective of the study is to determine whether methylation changes in the LEP gene in cord blood DNA are impacted by the maternal environment or affect neonatal adiposity measures. METHODS: A cross-sectional study of 114 full-term neonates born to healthy mothers with normal glucose tolerance was performed...
December 8, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27933507/determinants-of-maternal-vitamin%C3%A2-d-concentrations-in-slovenia-a%C3%A2-prospective-observational-study
#2
Andraž Dovnik, Faris Mujezinović, Milena Treiber, Breda Pečovnik Balon, Maksimiljan Gorenjak, Uroš Maver, Iztok Takač
OBJECTIVE: To analyze the vitamin D status of pregnant women in Slovenia and the factors influencing it. METHODS: The study was performed in Maribor University Medical Centre (location 46°N). Maternal serum 25-hydroxy-vitamin D (25(OH)D) in 4 groups of 100 pregnant women in 4 different seasons of the year was measured at the time of delivery. Data on life style, eating habits, sunbathing and intake of vitamin D supplements during pregnancy were obtained using a questionnaire...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27932430/bladder-agenesis-ectopic-ureters-and-a-multicystic-dysplastic-horseshoe-kidney-in-one-twin-newborn-with-normal-amniotic-fluid-index-in-utero
#3
Marium Naveed Khan, William F Walsh
A monochorionic-diamniotic twin baby presented with intrauterine growth restriction and anuria. The baby was found to have bladder agenesis, a pelvic dysplastic horseshoe kidney, vertebral anomalies, a ventricular septal defect and facial dysmorphisms. It was surprising to find no abnormalities in amniotic fluid indices prenatally, suggesting the possibility of urine output that declined as the pregnancy proceeded. Some degree of twin-to-twin transfusion of amniotic fluid was also possible, which could have rescued the oligohydramnios known to be associated with kidney and urinary tract abnormalities...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27931209/prevalence-and-risk-factors-for-vitamin-d-insufficiency-and-deficiency-at-birth-and-associated-outcome
#4
Ian Marshall, Rajeev Mehta, Charletta Ayers, Smita Dhumal, Anna Petrova
BACKGROUND: Occurrence and consequence of cord blood (CB) vitamin D insufficiency/deficiency has not been adequately explored despite rising concern regarding this topic in pediatrics. This study was designed to determine the rate, maternal risk factors, and clinical outcomes in infants in association with vitamin D insufficient/deficient status at birth. METHODS: American Academy of Pediatrics (AAP) defined levels (ng/mL) were utilized to categorize the vitamin D status in CB samples as deficient (5-15), insufficient (16-20), and sufficient (21-100)...
December 8, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27928892/is-consumption-of-sugar-sweetened-soft-drinks-during-pregnancy-associated-with-birth-weight
#5
Jacob H Grundt, Geir Egil Eide, Anne-Lise Brantsaeter, Margaretha Haugen, Trond Markestad
In Norway, there were parallel increases and subsequent decreases in birth weight (BW) and consumption of sugar-sweetened carbonated soft drinks (SSC) during the period 1990-2010, and by an ecological approach, we have suggested that the relationship was causal. The objective of this study was to examine if such a relationship was present in a prospectively followed cohort of pregnant women. The study population included 62,494 term singleton mother-infant dyads in the Norwegian Mother and Child Cohort Study (MoBa), a national prospective cohort study in Norway from 1999 to 2008...
December 7, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27928673/do-art-patients-face-higher-c-section-rates-during-their-stage-of-delivery-a-german-monocenter-experience
#6
Kay Neumann, Christoph Cirkel, Achim Rody, Daniel A Beyer
PURPOSE: The mode of delivery depends on multiple parameters. After assisted reproductive technology (ART), previous studies have shown elevated C-section rates but few studies differentiated between elective and emergency operations and different protocols of cryopreservation. Because these studies did not use multiparity as exclusion criteria which reduces confounding with previous pregnancies, aim of this study is to compare mode of delivery of different techniques of ART using data of primiparae only [1, 2]...
December 7, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27927846/risk-of-postpartum-psychosis-after-ivf-treatment-a-nationwide-case-control-study
#7
Josefin Vikström, Ann Josefsson, Mats Hammar, Marie Bladh, Gunilla Sydsjö
STUDY QUESTION: Is the risk of postpartum psychosis (PPP) increased in women who give birth after IVF treatment compared to after spontaneous conception? SUMMARY ANSWER: The risk of PPP is not higher in the group of women who give birth after IVF treatment compared with women who give birth after spontaneous conception. WHAT IS KNOWN ALREADY: Women who conceive using IVF treatment can experience higher levels of pregnancy-specific distress and are at increased risk of pre-eclampsia, an immune-related condition which in turn has been linked to PPP, as well as other pregnancy and delivery complications, which also serve as PPP risk factors...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27926975/large-for-gestational-age-infants-and-adverse-outcomes-among-uncomplicated-pregnancies-at-term
#8
Hector Mendez-Figueroa, Van Thi Thanh Truong, Claudia Pedroza, Suneet P Chauhan
Background While traumatic delivery with large for gestational age (LGA; birth weight above 90%) is acknowledged, there is paucity of data regarding other morbidity and mortality associated with LGA. Our hypothesis was that compared with appropriate for gestational age (AGA), LGA have a significantly higher rate of composite neonatal morbidity (CNM). Objective Our objective was to compare the CNM among uncomplicated LGA versus AGA at term (37 weeks or more) among all available Maternal-Fetal Medicine Units (MFMU) databases...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926974/pregnant-patient-knowledge-and-behavior-regarding-perinatal-oral-health
#9
Bernard Gonik, Eline Wilson, Melanie Mayberry, Bushra Yuki Joarder
Objective Perinatal oral health is important to obstetric practice, with significant implications for maternal, fetal, and infant health. This study sought to describe and compare knowledge and behavior related to perinatal oral health in two distinct populations of pregnant women. Methods An anonymous 13-question survey was distributed at two patient centers (urban teaching clinics and suburban referral center), examining patient knowledge and behaviors pertaining to oral health. Descriptive statistics were tabulated...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27924247/could-high-volume-of-physical-activities-in-early-pregnancy-interfere-with-deep-placentation
#10
Chantale Vachon-Marceau, Mario Girard, Michèle Bisson, Suzanne Demers, Isabelle Marc, Emmanuel Bujold
Background The impact of physical activity (PA) during pregnancy on obstetrical outcomes remains controversial. We followed pregnant women who reported more than 3 hours of sustained PA per week during the first trimester of pregnancy. Cases Total five eligible women were followed. We observed small placenta from the first trimester (median: 0.68; interquartile [IQ]: 0.62-0.97 multiples of median [MoM]) to delivery (median: 0.82; IQ: 0.71-0.94 MoM), high uterine artery pulsatility index in the first (median: 1...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27924145/demographic-characteristics-associated-with-pregnant-and-postpartum-youth-referred-for-mental-health-services-in-a-community-outreach-center
#11
Sandhaya Norris, Mark L Norris, Emily Sibbald, Tim Aubry, Megan E Harrison, Genevieve Lafontaine, Jasmine Gandhi
OBJECTIVE: Pregnancy in youth is considered high risk from a number of different standpoints. At present, limited data has explored demographic factors associated with Canadian cohorts of pregnant and postpartum youth seeking mental health services. We aimed to describe demographic characteristics associated with pregnant and postpartum youth and young adults referred for mental health services in the community and to compare this with data drawn from a hospital-based perinatal mental health clinic...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27922724/antenatal-breastfeeding-education-for-increasing-breastfeeding-duration
#12
REVIEW
Pisake Lumbiganon, Ruth Martis, Malinee Laopaiboon, Mario R Festin, Jacqueline J Ho, Mohammad Hakimi
BACKGROUND: Breast milk is well recognised as the best food source for infants. The impact of antenatal breastfeeding (BF) education on the duration of BF has not been evaluated. OBJECTIVES: To assess the effectiveness of antenatal breastfeeding (BF) education for increasing BF initiation and duration. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register on 1 March 2016, CENTRAL (The Cochrane Library, 2016, Issue 3), MEDLINE (1966 to 1 March 2016) and Scopus (January 1985 to 1 March 2016)...
December 6, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27922279/clinical-experience-with-an-ovarian-stimulation-protocol-for-intrauterine-insemination-adopting-a-gonadotropin-releasing-hormone-antagonist-at-low-dose
#13
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation (COS) for intrauterine insemination (IUI) have provided controversial results. The present study was undertaken to evaluate, whether the use of a half of the conventional dose of the GnRH antagonist cetrorelix can be effective in increasing the successful rate of IUI cycles. Patients started COS with human menopausal gonadotropin (hMG) on day three of the menstrual cycle. Cetrorelix was started when at least one follicle of ≥14 mm, was detected at the ultrasound scan, according to the flexible multiple daily dose protocol, and continued until the trigger day with recombinant hCG...
December 6, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27922230/consensus-statement-on-diagnosis-treatment-and-follow-up-of-cow-s-milk-protein-allergy-among-infants-and-children-in-turkey
#14
Aydan Kansu, Aysel Yüce, Buket Dalgıç, Bülent Enis Şekerel, Fügen Çullu-Çokuğraş, Haluk Çokuğraş
The present paper aims to provide experts' consensus on diagnosis and management of cow's milk protein allergy (CMPA) among infants and children in Turkey, based on review of available evidence-based guidelines, publications and experts' clinical experience. The experts agreed that CMPA diagnosis should be based on symptomatic evaluation and diagnostic elimination diet as followed by implementation of an open challenge test after disappearance of symptoms and confirmation of CMPA diagnosis in re-appearance of symptoms...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27921088/intra-uterine-extra-amniotic-versus-vaginal-misoprostol-for-termination-of-second-trimester-miscarriage-a-randomized-controlled-trial
#15
Abo Bakr Abbas Mitwaly, Ahmed Mohamed Abbas, Mohamed Sayed Abdellah
BACKGROUND: Termination of pregnancy in the second trimester using prostaglandins has been shown to be safe and effective. Misoprostol has multiple routes of administration; oral, vaginal, buccal, rectal and sublingual. OBJECTIVE: The study aims to compare the efficacy and safety of intrauterine extra-amniotic and vaginal misoprostol in a dose of 200 microgram every 4 hours for the termination of pregnancy in cases of second trimester miscarriage. MATERIALS AND METHODS: A prospective randomized open labeled clinical trial included 180 women with missed miscarriage in gestational age between 13 and 24 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27919542/total-hdl-cholesterol-efflux-capacity-in-healthy-children-associations-with-adiposity-and-dietary-intakes-of-mother-and-child
#16
H Khalil, C Murrin, M O'Reilly, K Viljoen, R Segurado, J O'Brien, R Somerville, F McGillicuddy, C C Kelleher
BACKGROUND AND AIMS: High-density lipoprotein (HDL) cholesterol efflux capacity in adults may be a measure of the atheroprotective property of HDL. Little however, is known about HDL cholesterol efflux capacity in childhood. We aimed to investigate the relationship between HDL cholesterol efflux capacity and childhood anthropometrics in a longitudinal study. METHODS AND RESULTS: Seventy-five children (mean age = 9.4 ± 0.4 years) were followed from birth until the age of 9 years...
October 12, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27919059/role-of-maternal-occupational-physical-activity-and-psychosocial-stressors-on-adverse-birth-outcomes
#17
Laura J Lee, Elaine Symanski, Philip J Lupo, Sarah C Tinker, Hilda Razzaghi, Wenyaw Chan, Adrienne T Hoyt, Mark A Canfield
OBJECTIVES: We examined the association of an array of estimated maternal occupational physical activities and psychosocial stressors during pregnancy with odds for preterm birth (PTB) and small-for-gestational age (SGA). METHODS: Data for infants born without major birth defects delivered from 1997 to 2009 whose mothers reported working at least 1 month during pregnancy were obtained from the National Birth Defects Prevention Study. We linked occupational codes to the US Department of Labor's Occupational Information Network, which provides estimates of exposure for multiple domains of physical activity and psychosocial stressors by occupational categories...
October 6, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27918586/impact-of-preconception-micronutrient-supplementation-on-anemia-and-iron-status-during-pregnancy-and-postpartum-a-randomized-controlled-trial-in-rural-vietnam
#18
Phuong H Nguyen, Melissa Young, Ines Gonzalez-Casanova, Hoa Q Pham, Hieu Nguyen, Truong V Truong, Son V Nguyen, Kimberly B Harding, Gregory A Reinhart, Reynaldo Martorell, Usha Ramakrishnan
OBJECTIVE: Preconception micronutrient interventions may be a promising approach to reduce anemia and iron deficiency during pregnancy, but currently we have limited data to inform policies. We evaluated whether providing additional pre-pregnancy weekly iron-folic acid (IFA) or multiple micronutrient (MM) supplements compared to only folic acid (FA) improves iron status and anemia during pregnancy and early postpartum. METHODS: We conducted a double blind randomized controlled trial in which 5011 Vietnamese women were provided with weekly supplements containing either only 2800 μg FA (control group), IFA (60 mg Fe and 2800 μg FA) or MM (15 micronutrients with similar amounts of IFA)...
2016: PloS One
https://www.readbyqxmd.com/read/27918427/prolactin-friend-or-foe-in-central-nervous-system-autoimmune-inflammation
#19
REVIEW
Massimo Costanza, Rosetta Pedotti
The higher prevalence of multiple sclerosis (MS) in females, along with the modulation of disease activity observed during pregnancy and the post-partum period, has suggested a hormonal influence in MS. Even if prolactin (PRL) does not belong to the sex hormones family, its crucial role in female reproduction and lactation has prompted great efforts to understand if PRL could represent a gender factor in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), the animal model for this disease...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27917690/pharmacological-management-of-pulmonary-embolism
#20
Bobby Gouin, Helia Robert-Ebadi, Marc Righini, Marc Blondon
Pulmonary embolism (PE) is a common and potentially severe manifestation of venous thromboembolism. Its management has relied on anticoagulation by vitamin K antagonists (VKA) for the past fifty years. Recently, new alternative drugs have been developed and dramatically modified both the treatment of acute PE and its secondary prevention. Areas covered: This review discusses the contemporary pharmacological treatment for PE, with a focus on anticoagulation options for non-high risk PE. In particular, the advent of direct oral anticoagulants (rivaroxaban, apixaban, edoxaban and dabigatran) and modalities for long-term prevention will be described...
December 3, 2016: Expert Opinion on Pharmacotherapy
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