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TAM, acceptance

Ali Garavand, Mohammah Mohseni, Heshmatollah Asadi, Manal Etemadi, Mohammad Moradi-Joo, Ahmad Moosavi
INTRODUCTION: The successful implementation of health information technologies requires investigating the factors affecting the acceptance and use of them. The aim of this study was to determine the most important factors affecting the adoption of health information technologies by doing a systematic review on the factors affecting the acceptance of health information technology. METHODS: This systematic review was conducted by searching the major databases, such as Google Scholar, Emerald, Science Direct, Web of Science, Pubmed, and Scopus...
August 2016: Electronic Physician
Ute Berndt, Bernd Leplow, Robby Schoenfeld, Tilmann Lantzsch, Regina Grosse, Christoph Thomssen
INTRODUCTION: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. METHODS: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI ('SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21)...
August 2016: Breast Care
Hassan Goodarzi, Seyed-Masoud Khatami, Hammidreza Javadzadeh, Sadrollah Mahmoudi, Hojjatollah Khajehpour, Soleiman Heidari, Morteza Khodaparast, Ali Ebrahimi, Hamidreza Rasouli, Mohammadreza Ghane, Mehrdad Faraji, Kasra Hassanpour
BACKGROUND: Picture archiving and communication system (PACS) has allowed the medical images to be transmitted, stored, retrieved, and displayed in different locations of a hospital or health system. Using PACS in the emergency department will eventually result in improved efficiency and patient care. In spite of the abundant benefits of employing PACS, there are some challenges in implementing this technology like users' resistance to accept the technology, which has a critical role in PACS success...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
G Galletti, F Caligaris-Cappio, M T S Bertilaccio
The development and progression of chronic B-cell tumors depend on a complex microenvironmental network of cells that include monocyte-derived macrophages. In chronic lymphocytic leukemia (CLL) the survival of malignant cells is supported in vitro by nurse-like cells, which differentiate from CD14(+) monocytes and have been identified as tumor-associated macrophages (TAMs). The role of the monocyte/macrophage lineage in CLL has been extensively studied in vitro, but only recently has been investigated in in vivo models...
October 14, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Seline Tam, Natasha Puri, Derek Stephens, Laura Mitchell, Meredith Giuliani, Janet Papadakos, Abha A Gupta
Adolescent and young adult (AYA) cancer patients under 40 should be made aware of their fertility risks and preservation options throughout their care. However, discussions on fertility preservation (FP) do not routinely occur. With a dearth of FP resources, oncology providers may lack knowledge around FP. Thus, informational needs can be unmet, leading to anxiety and distress in patients. Provision of pertinent and timely information can help patients cope better with their diagnosis. FP pamphlets were developed for men and women with cancer...
September 27, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Andrew Vanlint, Khai Loon Tam, Solomon Yu, Renuka Visvanathan
OBJECTIVES: An Observed Structured Clinical Examination (OSCE) was integrated into the assessment for senior medical students undertaking a 4.5-week geriatric medicine teaching block at one campus. The feasibility and acceptability of an OSCE were examined. METHODS: Students completed eight questions regarding the OSCE using a 6-point Likert scale and two additional questions, using free text, highlighting the strengths and potential areas for improvement. Changes were made every 6 months over a two-year period in response to student evaluation...
September 19, 2016: Australasian Journal on Ageing
Anke Berns, José-Luis Isla-Montes, Manuel Palomo-Duarte, Juan-Manuel Dodero
In the context of European Higher Education students face an increasing focus on independent, individual learning-at the expense of face-to-face interaction. Hence learners are, all too often, not provided with enough opportunities to negotiate in the target language. The current case study aims to address this reality by going beyond conventional approaches to provide students with a hybrid game-based app, combining individual and collaborative learning opportunities. The 4-week study was carried out with 104 German language students (A1...
2016: SpringerPlus
Santanu Mondal, Govindasamy Mugesh
Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring deiodination of thyroid hormones (THs) and play an important role in maintaining the TH concentration throughout the body. These enzymes also accept the decarboxylated thyroid hormone metabolites, iodothyronamines (TAMs), as substrates for deiodination. Naphthalene-based selenium and/or sulphur-containing small molecules have been shown to mediate the regioselective tyrosyl ring deiodination of thyroid hormones and their metabolites...
October 12, 2016: Organic & Biomolecular Chemistry
Allison Tong, Braden Manns, Brenda Hemmelgarn, David C Wheeler, Nicole Evangelidis, Peter Tugwell, Sally Crowe, Wim Van Biesen, Wolfgang C Winkelmayer, Donal O'Donoghue, Helen Tam-Tham, Jenny I Shen, Jule Pinter, Nicholas Larkins, Sajeda Youssouf, Sreedhar Mandayam, Angela Ju, Jonathan C Craig
Evidence-informed decision making in clinical care and policy in nephrology is undermined by trials that selectively report a large number of heterogeneous outcomes, many of which are not patient centered. The Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) Initiative convened an international consensus workshop on November 7, 2015, to discuss the identification and implementation of a potential core outcome set for all trials in hemodialysis. The purpose of this article is to report qualitative analyses of the workshop discussions, describing the key aspects to consider when establishing core outcomes in trials involving patients on hemodialysis therapy...
August 3, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Mohammadhiwa Abdekhoda, Maryam Ahmadi, Afsaneh Dehnad, Alireza Noruzi, Mahmodreza Gohari
BACKGROUND: In order to fulfill comprehensive interoperability and recognize the electronic medical records (EMRs') benefits, physicians' attitudes toward using and applying EMR must be recognized. OBJECTIVES: The purpose of this study was to present an integrated model of applying EMRs by physicians. METHODS: This was a cross sectional study in which a sample of 330 physicians working in hospitals affiliated to the Tehran University of medical sciences (TUMS) was selected...
2016: Applied Clinical Informatics
Ann E Kurth, Nok Chhun, Charles M Cleland, Michele Crespo-Fierro, José A Parés-Avila, John A Lizcano, Robert G Norman, Michele G Shedlin, Barbara E Johnston, Victoria L Sharp
BACKGROUND: Human immunodeficiency virus (HIV) disease in the United States disproportionately affects minorities, including Latinos. Barriers including language are associated with lower antiretroviral therapy (ART) adherence seen among Latinos, yet ART and interventions for clinic visit adherence are rarely developed or delivered in Spanish. OBJECTIVE: The aim was to adapt a computer-based counseling tool, demonstrated to reduce HIV-1 viral load and sexual risk transmission in a population of English-speaking adults, for use during routine clinical visits for an HIV-positive Spanish-speaking population (CARE+ Spanish); the Technology Acceptance Model (TAM) was the theoretical framework guiding program development...
2016: Journal of Medical Internet Research
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata
Tamoxifen (TAM) is a non-steroidal estrogen receptor antagonist that enhances erlotinib (ERL)-induced cytotoxicity in the treatment of NSCLC. ERL and TAM are metabolized by CYP3A4 enzymes. In addition, both drugs have the potential of altering the enzymatic activity through either inhibition (ERL) or induction (TAM). Thus it was expected that pharmacokinetics (PK) drug-drug interactions (DDIs) could be encountered following their co-administration. In this respect, a bioanalytical UPLC-MS/MS method has been developed and validated for the simultaneous determination of ERL and TAM in rat plasma samples, using ondansetron (OND) as an internal standard (IS)...
August 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yanling Wang, Qian Xiao, Liu Sun, Ying Wu
This study explores Chinese nurses' acceptance of PDA, using a questionnaire based on the framework of Technology Acceptance Model (TAM). 357 nurses were involved in the study. The results reveal the scores of the nurses' acceptance of PDA were means 3.18~3.36 in four dimensions. The younger of nurses, the higher nurses' title, the longer previous usage time, the more experienced using PDA, and the more acceptance of PDA. Therefore, the hospital administrators may change strategies to enhance nurses' acceptance of PDA, and promote the wide application of PDA...
2016: Studies in Health Technology and Informatics
Tsai-Hsuan Tsai, Hsien-Tsung Chang, Yi-Lun Ho
Many studies have noted that the use of social networks sites (SNSs) can enhance social interaction among the elderly and that the motivation for the elderly to use SNSs is to keep in contact with remote friends and family or the younger generation. Memotree is designed to promote intergenerational family communication. The system incorporates the Family Tree design concept and provides family communication mechanisms based on the Family Communication Scale. In addition, the system optimizes hardware and interface use to conform to the specific needs of older and substantially younger individuals...
2016: PloS One
Nicole Cook, Sandra L Winkler
BACKGROUND: Virtual worlds allow users to communicate and interact across various environments, scenarios, and platforms. Virtual worlds present opportunities in health care to reduce the burden of illness and disability by supporting education, rehabilitation, self-management, and social networking. The application of virtual worlds to older adults who bear the burden and cost of health conditions associated with age has not been evaluated. OBJECTIVE: The aim of this study is to explore the usability, ease of use, and enjoyment of a virtual world by older adults, the types of virtual world activities that older adults may engage in, and the perceptions of older adults regarding the application of virtual worlds in health care...
2016: JMIR Research Protocols
Husniye Baser, Oya Topaloglu, Abbas Ali Tam, Afra Alkan, Aydan Kilicarslan, Reyhan Ersoy, Bekir Cakir
Thyroid tumors of uncertain malignant potential (TT-UMP) comprise an accepted subgroup of follicular-patterned thyroid tumors for which benignancy or malignancy cannot be precisely assessed. We aimed to evaluate the demographic characteristics, ultrasound (US) findings, and cytological results of patients with TT-UMP and compare these findings to a classical variant of papillary thyroid carcinoma (CV-PTC) and non-encapsulated follicular variant of PTC (NEFV-PTC) patients; we also evaluated the immunohistochemical characteristics of patients with TT-UMP...
September 2016: Endocrine Pathology
Teresa Mei Lee Chiu, Katharine Tai Wo Tam, Choi Fong Siu, Phyllis Wai Ping Chau, Malcolm Battersby
BACKGROUND: The Partners in Health (PIH) scale is a measure designed to assess the generic knowledge, attitudes, behaviors, and impacts of self-management. A cross-cultural adaptation of the PIH for use in Hong Kong was evaluated in this study. This paper reports the validity and reliability of the Chinese version of PIH (C-PIH[HK]). METHOD: A 12-item PIH was translated using forward-backward translation technique and reviewed by individuals with chronic diseases and health professionals...
May 23, 2016: Quality of Life Research
Manuela Liguori, Chiara Buracchi, Fabio Pasqualini, Francesca Bergomas, Samantha Pesce, Marina Sironi, Fabio Grizzi, Alberto Mantovani, Cristina Belgiovine, Paola Allavena
Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis. Human resting monocytes and in vitro-differentiated macrophages expressed substantial levels of the functional TRAIL receptors (TRAIL-R1 and TRAIL-R2), while neutrophils and lymphocytes mostly expressed the non-signaling decoy receptor (TRAIL-R3). Accordingly, exclusively monocytes and macrophages activated caspase-8 and underwent apoptosis upon recombinant TRAIL treatment...
May 13, 2016: Oncotarget
Y Liang, X S Chen, J Y Wu, O Huang, Y Zong, L J Nie, Q Fang, J R He, L Zhu, W G Chen, Y F Li, K W Shen
OBJECTIVE: To analyze the applied condition of ovary function suppression (OFS) before and after joint analysis of TEXT and SOFT trials and SOFT trial, and to identify the relevant factors of OFS usage. METHODS: The analysis was performed in premenopausal women with hormone receptor (HR) positive breast cancer receiving surgical treatment from Apr 2013 to Oct 2015 in Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Adjuvant treatment strategy was made in the multidisciplinary team (MDT) meetings...
May 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Luca Gelsomino, Guowei Gu, Yassine Rechoum, Amanda R Beyer, Sasha M Pejerrey, Anna Tsimelzon, Tao Wang, Kenneth Huffman, Andrew Ludlow, Sebastiano Andò, Suzanne A W Fuqua
The purpose of this study was to address the role of ESR1 hormone-binding mutations in breast cancer. Soft agar anchorage-independent growth assay, Western blot, ERE reporter transactivation assay, proximity ligation assay (PLA), coimmunoprecipitation assay, silencing assay, digital droplet PCR (ddPCR), Kaplan-Meier analysis, and statistical analysis. It is now generally accepted that estrogen receptor (ESR1) mutations occur frequently in metastatic breast cancers; however, we do not yet know how to best treat these patients...
June 2016: Breast Cancer Research and Treatment
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