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https://www.readbyqxmd.com/read/28732286/development-of-liquid-chromatographic-methods-for-enantioseparation-and-sensitive-detection-of-%C3%AE-adrenolytics-%C3%AE-2-agonists-in-human-plasma-using-a-single-enantiomer-reagent
#1
Poonam Malik, Ravi Bhushan
Enantioseparation of four commonly used β-adrenolytics (bisoprolol, salbutamol, and carvedilol, marketed as racemic mixtures) has been achieved by both TLC and RPHPLC via an indirect approach. A new chiral reagent, (S)-naproxen benzotriazole ester, was synthesized and it was characterized by UV, IR, (1)HNMR, elemental analysis and polarimetry. It was used to synthesize diastereomeric derivatives of the three β-adrenolytics under microwave irradiation. TLC separation of diastereomeric derivatives was achieved which were then isolated by preparative approach; these were characterized and were used as standard reference for determining absolute configuration of diastereomeric derivatives and for establishing validated HPLC method for enantioseparation and sensitive detection of the three β-adrenolytics in human plasma...
July 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28732133/ionization-and-collision-induced-dissociation-of-steroid-bis-glucuronides
#2
Argitxu Esquivel, Xavier Matabosch, Aristotelis Kotronoulas, Georgina Balcells, Jesús Joglar, Rosa Ventura
Studies on steroid metabolism are of utmost importance to improve the detection capabilities of anabolic androgenic steroids (AAS) misuse in sports drug testing. In humans, glucuronoconjugates are the most abundant phase II metabolites of AAS. Bis-glucuronidation is a reaction where two separated functional groups on the same molecule are conjugated with glucuronic acid. These metabolites have not been studied in depth for steroids and could be interesting markers for doping control. The aim of the present work was to study the ionization and collision induced dissociation of steroid bis-glucuronides to be able to develop mass spectrometric analytical strategies for their detection in urine samples after AAS administration...
July 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28731776/predicting-flory-huggins-%C3%AF-from-simulations
#3
Wenlin Zhang, Enrique D Gomez, Scott T Milner
We introduce a method, based on a novel thermodynamic integration scheme, to extract the Flory-Huggins χ parameter as small as 10^{-3}kT for polymer blends from molecular dynamics (MD) simulations. We obtain χ for the archetypical coarse-grained model of nonpolar polymer blends: flexible bead-spring chains with different Lennard-Jones interactions between A and B monomers. Using these χ values and a lattice version of self-consistent field theory (SCFT), we predict the shape of planar interfaces for phase-separated binary blends...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731634/measuring-the-quality-of-hospital-food-services-development-and-reliability-of-a-meal-quality-audit-tool
#4
Merrilyn Banks, Mary Hannan-Jones, Lynda Ross, Ann Buckley, Jennifer Ellick, Adrienne Young
AIM: To develop and test the reliability of a Meal Quality Audit Tool (MQAT) to audit the quality of hospital meals to assist food service managers and dietitians in identifying areas for improvement. METHODS: The MQAT was developed using expert opinion and was modified over time with extensive use and feedback. A phased approach was used to assess content validity and test reliability: (i) trial with 60 dietetic students, (ii) trial with 12 food service dietitians in practice and (iii) interrater reliability study...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731343/-roller-wheel-pt-containing-small-molecules-and-the-impact-of-rollers-on-material-crystallinity-electronic-properties-and-solar-cell-performance
#5
Wenhan He, Maksim Y Livshits, Diane A Dickie, Zhen Zhang, Luis E Mejiaortega, Jeffrey J Rack, Qin Wu, Yang Qin
We report the synthesis, characterization and detailed comparison of a series of novel Pt-bisacetylide containing conjugated small molecules possessing an unconventional "roller-wheel" shaped structure that is distinctly different from the "dumbbell" designs in traditional Pt-bisacetylide containing conjugated polymers and small molecules. The relationship between the chemical nature and length of the "rollers" and the electronic and physical properties of the materials are carefully studied by steady state spectroscopy, cyclic voltammetry, differential scanning calorimetry, single-crystal X-ray diffraction, transient absorption spectroscopy, theoretical calculation and device application...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28731318/ultrafast-ionic-liquid-assisted-microwave-synthesis-of-sno-microflowers-and-their-superior-sodium-ion-storage-performance
#6
Bingsheng Qin, Huang Zhang, Thomas Diemant, Dorin Geiger, Rinaldo Raccichini, R Jürgen Behm, Ute Kaiser, Alberto Varzi, Stefano Passerini
Tin oxide (SnO) is considered one of the most promising metal oxides for utilization as anode material in sodium ion batteries (SIBs), due to its ease of synthesis, high specific gravimetric capacity and satisfactory cycling performance. However, to aim at practical applications, the coulombic efficiency during cycling needs to be further improved, which requires a deeper knowledge of its working mechanism. Here, a microflower-shaped SnO material is synthesized by means of an ultrafast ionic liquid-assisted microwave method...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28731286/impact-of-fluorine-atoms-on-perylene-diimide-derivative-for-fullerene-free-organic-photovoltaics
#7
Liang Zhao, Hua Sun, Xiaoyuan Liu, Changmei Liu, Haiquan Shan, Jiuxu Xia, Zongxiang Xu, Fei Chen, Zhi-Kuan Chen, Wei Huang
The incorporation of fluorine atoms in organic semiconducting materials has attracted much attention recently due to its unique function to manipulate the molecular packing, film morphology and molecular energy levels. In this work, two perylenediimide (PDI) derivatives FPDI-CDTph and FPDI-CDTph2F were designed and synthesized to investigate the impact of fluorination on non-fullerene acceptors. Both FPDI-CDTph and FPDI-CDTph2F exhibited strong and broad absorption profiles, suitable lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) energy levels, and good electron transport ability...
June 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28731086/microfluidic-and-nanofluidic-phase-behaviour-characterization-for-industrial-co2-oil-and-gas
#8
REVIEW
Bo Bao, Jason Riordon, Farshid Mostowfi, David Sinton
Microfluidic systems that leverage unique micro-scale phenomena have been developed to provide rapid, accurate and robust analysis, predominantly for biomedical applications. These attributes, in addition to the ability to access high temperatures and pressures, have motivated recent expanded applications in phase measurements relevant to industrial CO2, oil and gas applications. We here present a comprehensive review of this exciting new field, separating microfluidic and nanofluidic approaches. Microfluidics is practical, and provides similar phase properties analysis to established bulk methods with advantages in speed, control and sample size...
July 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28730996/correspondence-between-the-electronic-structure-and-phase-separation-in-a-k-doped-fese-system
#9
Chen Liu, Jia Li Zhao, Jia-Ou Wang, Hai-Jie Qian, Rui Wu, Huan-Hua Wang, Nian Zhang, Kurash Ibrahim
Phase separated potassium intercalated FeSe thin films have been synthesized by pulsed laser deposition (PLD). The coexistence of FeSe phase and 245 phase was investigated both by x-ray photoemission spectroscopy (XPS) and X-ray diffraction (XRD). The volume ratio of these two phases is sensitive to temperatures and amount of extra potassium dosing. The XPS and ultraviolet photoelectron spectroscopy (UPS) results indicated that these two phases shows the different hybridization strength between adjacent Fe layer and Se layer...
July 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28730706/chromatographic-profiles-of-tryptophan-and-kynurenine-enantiomers-derivatized-with-s-4-3-isothiocyanatopyrrolidin-1-yl-7-n-n-dimethylaminosulfonyl-2-1-3-benzoxadiazole-using-lc-ms-ms-on-a-triazole-bonded-column
#10
Hideaki Iizuka, Takahiro Harashima, Shuhei Takahashi, Ryosuke Kuwabara, Yoko Naito, Tatsuya Sakamoto, Mayu Onozato, Hideaki Ichiba, Takeshi Fukushima
d- and l-Tryptophan (Trp) and d- and l-kynurenine (KYN) were derivatized with a chiral reagent, (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole (DBD-PyNCS), and were separated enantiomerically by high-performance liquid chromatography (HPLC) equipped with a triazole-bonded column (Cosmosil HILIC) using tandem mass spectrometric (MS/MS) detection. Effects of column temperature, salt (HCO2 NH4 ) concentration, and pH of the mobile phase in the enantiomeric separation, followed by MS detection of (S)-DBD-PyNCS-d,l-Trp and -d,l-KYN, were investigated...
July 21, 2017: Chirality
https://www.readbyqxmd.com/read/28730213/magnetic-separation-its-application-in-mining-waste-purification-medicine-biochemistry-and-chemistry
#11
REVIEW
M Iranmanesh, J Hulliger
The use of strong magnetic field gradients and high magnetic fields generated by permanent magnets or superconducting coils has found applications in many fields such as mining, solid state chemistry, biochemistry and medical research. Lab scale or industrial implementations involve separation of macro- and nanoparticles, cells, proteins, and macromolecules down to small molecules and ions. Most promising are those attempts where the object to be separated is attached to a strong magnetic nanoparticle. Here, all kinds of specific affinity interactions are used to attach magnetic carrier particles to mainly objects of biological interest...
July 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28730199/the-amorphous-state-first-principles-derivation-of-the-gordon-taylor-equation-for-direct-prediction-of-the-glass-transition-temperature-of-mixtures-estimation-of-the-crossover-temperature-of-fragile-glass-formers-physical-basis-of-the-rule-of-2-3
#12
Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco
Predicting the glass transition temperature (Tg) of mixtures has applications that span across industries and scientific disciplines. By plotting experimentally determined Tg values as a function of the glass composition, one can usually apply the Gordon-Taylor (G-T) equation to determine the slope, k, which subsequently can be used in Tg predictions. Traditionally viewed as a phenomenological/empirical model, this work proposes a physical basis for the G-T equation. The proposed equations allow for the calculation of k directly and, hence, they determine/predict the Tg values of mixtures algebraically...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28729138/spatial-working-memory-in-the-touchscreen-operant-platform-is-disrupted-in-female-rats-by-ovariectomy-but-not-estrous-cycle
#13
Alyssa M Sbisa, Andrea Gogos, Maarten van den Buuse
Learning and memory deficits have been described in rats and mice after ovariectomy (OVX) and across the estrous cycle. Preclinical researchers therefore often avoid using female animals and, consequently, a large male bias exists in the preclinical cognitive literature. In the present study we examined the role of sex hormones in the touchscreen operant platform using the spatial working memory trial unique nonmatching-to-location (TUNL) task. Twenty-nine Long Evans rats were trained to acquire the TUNL task including three incremental spatial separations (S0, S1, S2)...
July 17, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28726899/enhanced-interfacial-activity-of-multi-arm-poly-ethylene-oxide-star-polymers-relative-to-linear-poly-ethylene-oxide-at-fluid-interfaces
#14
Yun-Ru Huang, Melissa Lamson, Krzysztof Matyjaszewski, Robert D Tilton
Interfacial tension reduction, dynamic dilatational elasticity and extent of adsorption were investigated for linear poly(ethylene oxide) (PEO) chains of varying molecular weight and for PEO star polymers with an average of 64 arms per star at air/water, xylene/water, and cyclohexane/water interfaces. Adsorption on planar interfaces was monitored by ellipsometry, while interfacial tension and dilatational elasticity were measured separately by pendant drop tensiometry. Previously reported to be efficient emulsifiers, PEO stars are shown here to also be more effective foaming agents than linear PEO...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726748/effect-of-air-pollution-on-menstrual-cycle-length-a-prognostic-factor-of-women-s-reproductive-health
#15
Anna Merklinger-Gruchala, Grazyna Jasienska, Maria Kapiszewska
Air pollution can influence women's reproductive health, specifically menstrual cycle characteristics, oocyte quality, and risk of miscarriage. The aim of the study was to assess whether air pollution can affect the length of the overall menstrual cycle and the length of its phases (follicular and luteal). Municipal ecological monitoring data was used to assess the air pollution exposure during the monitored menstrual cycle of each of 133 woman of reproductive age. Principal component analyses were used to group pollutants (PM10, SO₂, CO, and NOx) to represent a source-related mixture...
July 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28726707/three-dimensional-eulerian-eulerian-simulation-on-hydrodynamics-in-dissolved-air-flotation-tank-with-different-turbulence-models
#16
Baoqing Deng, Qiong Ding, Daqiang Ge
The Eulerian-Eulerian approach is used to simulate the two phase flow of air and water in a dissolved air flotation (DAF) tank. Unsteady simulation is adopted to obtain the quasi-steady result. The two dimensional model cannot capture the three dimensional feature of flow pattern in the tank. The three dimensional model reproduces the stratification structure observed in the experiment and obtains the satisfactory volume fraction of air bubbles in the separation zone. To account for the turbulence effect, four two-equation turbulence models are evaluated...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726485/annals-express-20%C3%AE-and-20%C3%AE-dihydrocortisone-may-interfere-in-lc-ms-ms-determination-of-cortisol-in-saliva-and-urine
#17
Marlen Israelsson, Ralph Brattsand, Goran Brattsand
BACKGROUND: LC-MS/MS methods offer high selectivity in cortisol determinations. However, endogenous steroid metabolites may still interfere and compromise the results, for example in the diagnosis of Cushing´s syndrome. Erroneously elevated cortisol may, in particular, be misleading at the low concentrations found in salivary samples obtained at late night and after dexamethasone suppression. METHODS: Interferences in our LC-MS/MS method used for determination of cortisol in saliva and urine were identified by comparing their retention times and mass spectra with those of pure candidate substances...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28726286/a-new-sample-preparation-and-separation-combination-for-the-precise-accurate-and-simultaneous-determination-of-uracil-and-dihydrouracil-in-human-plasma-by-reversed-phase-hplc
#18
Wen Pan, Yuandong Li, Yan Feng, Fan Yang, Haizhou Liu
We have developed an efficient procedure and detection method using reversed-phase high-performance liquid chromatography for the simultaneous measurement of uracil and dihydrouracil in human plasma. The procedure, based on chromatographic conditions and sample preparation, was optimized and validated. Optimization of the sample preparation included of deproteinization, extraction and clean-up. A new sample preparation method which results in an improved extraction yield of analytes and significantly reduced interference at low-wavelength UV detection was developed...
July 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28725319/autologous-stromal-vascular-fraction-in-the-intravenous-treatment-of-end-stage-chronic-obstructive-pulmonary-disease-a-phase-i-trial-of-safety-and-tolerability
#19
Kristin Comella, Jesus A Perez Blas, Tom Ichim, Javier Lopez, Jose Limon, Ruben Corral Moreno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treatment exists capable of either reversing or even interrupting its course. It afflicts more than 5% of the population in many countries, and it accordingly represents the third most frequent cause of death in the US, where it accounts for more than 600 billion in health care costs, morbidity, and mortality. Adipose tissue contains within its stromal compartment a high abundance of adipose stem/stromal cells (ASCs), which can be readily separated from the adipocyte population by methods which require less than 2 h of processing time and yield a concentrated cellular preparation termed the stromal vascular fraction (SVF)...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28725141/high-performance-thin-layer-chromatography-based-concurrent-estimation-of-biomarkers-ent-phyllanthidine-and-rutin-in-the-dried-aerial-parts-of-flueggea-virosa
#20
Nasir A Siddiqui, Ramzi A Mothana, Adnan J Al-Rehaily, Perwez Alam, Muhammad Yousaf, Sarfaraz Ahmed, Abdulrahman Alatar
The biomarkers are needed to be defined for standardization purposes so that safe and effective herbal formulations can be catered to the society. There is an urgent need for statistical support of herbal drugs because most of the herbal products are still used in the non-standardized form. This study is based on the development of a simple and sensitive RP-HPTLC method for concurrent estimation of two biomarkers ent-phyllanthidine and rutin in the methanol extract of aerial parts of Flueggea virosa. The developed method was found to be simple, economic and sensitive...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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