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icg lung cancer

Andrew D Newton, Gregory T Kennedy, Jarrod D Predina, Philip S Low, Sunil Singhal
Intraoperative molecular imaging is a promising new technology with numerous applications in lung cancer surgery. Accurate identification of small nodules and assessment of tumor margins are two challenges in pulmonary resections for cancer, particularly with increasing use of video-assisted thoracoscopic surgery (VATS). One potential solution to these problems is intraoperative use of a fluorescent contrast agent to improve detection of cancer cells. This technology requires both a targeted fluorescent dye that will selectively accumulate in cancer cells and a specialized imaging system to detect the cells...
October 2016: Journal of Thoracic Disease
Chen-Ping Hsieh, Yun-Hen Liu, Yi-Cheng Wu, Ming-Ju Hsieh, Yin-Kai Chao
BACKGROUND: Pulmonary segmentectomy with radical lymphadenopathy has been considered effective to manage small primary lung cancers [1, 2]. This procedure provides the advantages of minimal invasive surgery and is reported sufficient for safe margin. However, segmentectomy is more difficult to be performed than lobectomy because intersegmental plane cannot be detected easily. Several methods have been reported for identifying the actual intersegmental plane [3-7], but the sensitivity of these methods is limited to the lung conditions like patients with emphysematous lung and needed skilled surgeon to perform...
November 11, 2016: Surgical Endoscopy
Priya Patel, Tatsuya Kato, Hideki Ujiie, Hironobu Wada, Daiyoon Lee, Hsin-Pei Hu, Kentaro Hirohashi, Jin Young Ahn, Jinzi Zheng, Kazuhiro Yasufuku
BACKGROUND: Investigation of CF800, a novel PEGylated nano-liposomal imaging agent containing indocyanine green (ICG) and iohexol, for real-time near infrared (NIR) fluorescence and computed tomography (CT) image-guided surgery in an orthotopic lung cancer model in nude mice. METHODS: CF800 was intravenously administered into 13 mice bearing the H460 orthotopic human lung cancer. At 48 h post-injection (peak imaging agent accumulation time point), ex vivo NIR and CT imaging was performed...
2016: PloS One
Laura Jeffords Moore, Lopamudra Das Roy, Ru Zhou, Priyanka Grover, Shu-Ta Wu, Jennifer M Curry, Lloye M Dillon, Priya M Puri, Mahboubeh Yazdanifar, Rahul Puri, Pinku Mukherjee, Didier Dréau
BACKGROUND: Earlier detection of transformed cells using target-specific imaging techniques holds great promise. We have developed TAB 004, a monoclonal antibody highly specific to a protein sequence accessible in the tumor form of MUC1 (tMUC1). We present data assessing both the specificity and sensitivity of TAB 004 in vitro and in genetically engineered mice in vivo. METHODS: Polyoma Middle T Antigen mice were crossed to the human MUC1.Tg mice to generate MMT mice...
August 2016: Translational Oncology
Hiroaki Nomori, Yue Cong, Hiroshi Sugimura
PURPOSES: Sentinel node identification using indocyanine green (ICG) is not only simpler, but also more cost-effective, than using radioisotope tracers. We herein examined the utility and pitfalls of sentinel node (SN) identification using ICG during segmentectomy in patients with cT1N0M0 non-small cell lung cancer (NSCLC). METHODS: ICG was injected around the tumor after thoracotomy, followed by segmentectomy and lymph node dissection, in 135 patients with cT1N0M0 NSCLC...
August 2016: Surgery Today
Jack X Jiang, Jane J Keating, Elizabeth M De Jesus, Ryan P Judy, Brian Madajewski, Ollin Venegas, Olugbenga T Okusanya, Sunil Singhal
Surgery is the most effective method to cure patients with solid tumors. New techniques in near-infrared (NIR) cancer imaging are being used to identify surgical margins and residual tumor cells in the wound. Our goal was to determine the optimal time and dose for imaging solid tumors using Indocyanine Green. Syngeneic murine flank tumor models were used to test NIR imaging of ICG at various doses ranging from 0 to 10 mg/kg. Imaging was performed immediately after injection and up to 72 hours later. Biodistribution in the blood and murine organs were quantified by spectroscopy and fluorescence microscopy...
2015: American Journal of Nuclear Medicine and Molecular Imaging
Hironobu Wada, Kentaro Hirohashi, Takashi Anayama, Takahiro Nakajima, Tatsuya Kato, Harley H L Chan, Jimmy Qiu, Michael Daly, Robert Weersink, David A Jaffray, Jonathan C Irish, Thomas K Waddell, Shaf Keshavjee, Ichiro Yoshino, Kazuhiro Yasufuku
BACKGROUND: The use of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) for sentinel lymph node (SN) mapping has been investigated in lung cancer; however, this has not been fully adapted for minimally invasive surgery (MIS). The aim of our study was to develop a minimally invasive SN mapping integrating pre-operative electro-magnetic navigational bronchoscopy (ENB)-guided transbronchial ICG injection and intraoperative NIR thoracoscopic imaging. METHODS: A NIR thoracoscope was used to visualize ICG fluorescence...
2015: PloS One
Xueyan Zhang, Yuqing Lou, Xiaoxuan Zheng, Huimin Wang, Jiayuan Sun, Qianggang Dong, Baohui Han
BACKGROUND: Previous study has confirmed that the occurrence of Wnt pathway activation is associated with risk of non-small-cell lung cancer recurrence. However, whether the pharmacologic blocking of the Wnt signaling pathway could provide therapeutic possibility remains unknown. The aim of the present study was to evaluate the therapeutic functions of the Wnt signaling pathway inhibitor pyrvinium pamoate (PP) on lung cancer stem cells (LCSCs) in vitro. METHODS: Colony formation and sphere culture were performed to enrich LCSCs from three lung cancer cell lines: PC9, SPC-A1, and A549...
2015: Drug Design, Development and Therapy
Motone Kuriyama, Akiko Yano, Yukitaka Yoshida, Maiko Kubo, Shinsuke Akita, Nobuyuki Mitsukawa, Kaneshige Satoh, Shin Yamamoto, Shiro Sasaguri, Kazumasa Orihashi
PURPOSE: In most general thoracic operations performed via standard posterolateral thoracotomy, such as for descending aortic aneurysms and lung cancer, the latissimus dorsi (LD) muscle is divided. However, division of the LD can hamper reconstructive surgery because the initial operation creates unstable blood flow to the divided LD. We conducted this study to assess blood flow in a divided distal LD muscle flap using intraoperative indocyanine green-fluorescence angiography (ICG-FA) with the Hyper Eye Medical System(®) (Mizuho Medical Co...
March 2016: Surgery Today
King Chi Chan, Lai Sheung Chan, Joseph Chok Yan Ip, Carman Lo, Timothy Tak Chun Yip, Roger Kai Cheong Ngan, Ricky Ngok Shun Wong, Kwok Wai Lo, Wai Tong Ng, Anne Wing Mui Lee, George Sai Wah Tsao, Michael Kahn, Maria Li Lung, Nai Ki Mak
Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated transcription of stem cell associated genes and enhance p300/β-catenin-mediated transcription, thereby reducing the CSC-like population via forced differentiation. In this study, we aimed to evaluate the effect of ICG-001 on the CSC-like population, and the combination effect of ICG-001 with cisplatin in the C666-1 EBV-positive NPC cells...
April 21, 2015: Scientific Reports
Kentaro Hirohashi, Takashi Anayama, Hironobu Wada, Takahiro Nakajima, Tatsuya Kato, Shaf Keshavjee, Kazumasa Orihashi, Kazuhiro Yasufuku
The present study was designed to evaluate the efficacy of photothermal ablation therapy for lung cancer by low-power near-infrared laser and topical injection of indocyanine green (ICG). In vitro study 1: an 808 nm laser with 250 mW was irradiated for 10 minutes using different dilutions of ICG and the temporal thermal effect was monitored. ICG (1 mL of 0.5 g/L) was heated to a temperature of >30°C from the base temperature by laser irradiation. In vitro study 2: the cytotoxic effect of hyperthermia on human lung cancer cells was examined in different temperature and time settings...
April 2015: Journal of Bronchology & Interventional Pulmonology
Yujin Oh, Yun-Sang Lee, Yu Hua Quan, Yeonho Choi, Jae Min Jeong, Beop-Min Kim, Hyun Koo Kim
PURPOSE: This study was performed to validate a newly developed sentinel lymph node (SLN) targeting tracer, indocyanine green-neomannosyl human serum albumin (ICG:MSA), and a thoracoscopic version of the intraoperative color and fluorescence imaging system (ICFIS) for lung cancer SLN mapping. METHODS: ICG alone or ICG:MSA (5 μg/kg) was injected into the rat thigh, and the results were compared. The fluorescence signal-to-background ratios of SLNs were recorded and evaluated over a 2-h period by using ICFIS...
April 2014: Annals of Surgical Oncology
Simon Mathew, Tatsuya Murakami, Hirotaka Nakatsuji, Haruki Okamoto, Nobuhiro Morone, John E Heuser, Mitsuru Hashida, Hiroshi Imahori
A hydrophobic gadolinium bis(naphthalocyanine) sandwich complex (GdSand) possessing several absorbances across visible and infrared wavelengths (up to 2500 nm) was solubilized in aqueous solution by uptake into a nascent mutant high-density lipoprotein (HDL) nanocarrier. The HDL nanocarrier was additionally functionalized with a trans-activator of transcription peptide sequence to promote efficient cell penetration of the drug delivery system (cpHDL). The dye-loaded nanocarrier (GdSand@cpHDL) exhibited photothermal heat generation properties upon irradiation with near-infrared (NIR) laser light, with controllable heat generation abilities as a function of the incident laser light power...
October 22, 2013: ACS Nano
Fuping Gao, Linlin Li, Changhui Fu, Liya Nie, Dong Chen, Fangqiong Tang
Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.
October 11, 2013: Advanced Materials
Denis M Gilmore, Onkar V Khullar, Michael T Jaklitsch, Lucian R Chirieac, John V Frangioni, Yolonda L Colson
OBJECTIVES: Early-stage non-small cell lung cancer (NSCLC) has a high recurrence rate and poor 5-year survival, particularly if lymph nodes are involved. Our objective was to perform a dose-escalation study to assess safety and feasibility of intraoperative near-infrared (NIR) fluorescence imaging to identify the first tumor-draining lymph nodes (ie, sentinel lymph nodes [SLNs] in patients with NSCLC). METHODS: A-dose escalation phase 1 clinical trial assessing real-time NIR imaging after peritumoral injection of 3...
September 2013: Journal of Thoracic and Cardiovascular Surgery
Takashi Anayama, Takahiro Nakajima, Shaf Keshavjee, Kazuhiro Yasufuku
SESSION TYPE: Thoracic Surgery IPRESENTED ON: Monday, October 22, 2012 at 11:15 AM - 12:30 PMPURPOSE: Endbronchial laser ablation is mainly used for treatment of endobronchial tumors. In this study, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) was utilized for ablative therapy for target lesions located in mediastinum. We examined the efficacy of indocyanine green (ICG) enhanced laser photoablation to lung cancer in both in-vitro and ex-vivo setting. The concept of EBUS-guided ICG injection / laser ablation was tested using in-vivo porcine model...
October 1, 2012: Chest
Yujin Oh, Yu Hua Quan, Yeonho Choi, Choong Ki Kim, Heezoo Kim, Hyun Koo Kim, Beop-Min Kim
OBJECTIVES: We developed a multimodal optical imaging system for intraoperative visualization of sentinel lymph nodes (SLNs). This study is to validate our system by showing SLNs in the lung through combined optical color and fluorescent image with indocyanine green (ICG) and ICG with human serum albumin (HSA). METHODS: Identical ICG concentrations of ICG only or ICG:HSA was injected into the rat footpad and porcine lung. Absolute amounts of the fluorescents were scaled on the basis of animal weights...
December 2013: Journal of Thoracic and Cardiovascular Surgery
Onkar V Khullar, Denis M Gilmore, Aya Matsui, Yoshitomo Ashitate, Yolonda L Colson
BACKGROUND: The presence of lymph node metastasis is the most important prognostic factor in early non-small cell lung cancer. Our objective was to develop a rapid, simple, and reliable method for thoracic sentinel lymph node (SLN) identification using near-infrared fluorescence imaging and clinically available contrast agents. METHODS: Indocyanine green (ICG) reconstituted in saline, human serum albumin, human fresh frozen plasma, and autologous porcine plasma was evaluated for optimal formulation and dosing for SLN within porcine lungs...
January 2013: Annals of Thoracic Surgery
Kazuhiro Imai, Yoshihiro Minamiya, Hajime Saito, Taku Nakagawa, Manabu Ito, Takashi Ono, Satoru Motoyama, Yusuke Sato, Hayato Konno, Jun-ichi Ogawa
PURPOSE: Lymphatic spread of lung carcinoma to the mediastinum is a key determinant of prognosis. The lymph flow often carries metastases from the pulmonary segment directly into the mediastinal lymph nodes, without passing through the hilar nodes. This phenomenon is termed as "skip metastasis." This study investigated the subpleural lymphatic flow to the mediastinum using indocyanine green (ICG) with a near-infrared fluorescence imaging system. METHODS: Seventeen patients with lung cancer were enrolled in this study...
March 2013: Surgery Today
Didel M Mahounga, Lingling Shan, Cao Jie, Changli Du, Shunan Wan, Yueqing Gu
PURPOSE: A novel near infrared fluorescent probe, L-methyl-methionine (Met)-ICG-Der-02, was synthesized and characterized for in vivo imaging of tumors and early diagnosis of cancers. METHOD: Met was conjugated with ICG-Der-02 dye through the amide bond function by ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide catalysis chemistry. Met-ICG-Der-02 probe uptake was evaluated on PC3, MDA-MB-231, and human embryonic lung fibroblast cell lines...
December 2012: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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