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https://www.readbyqxmd.com/read/28921656/animal-models-for-studying-the-etiology-and-treatment-of-low-back-pain
#1
REVIEW
Changgui Shi, Sujun Qiu, Scott M Riester, Vaskar Das, Bingqian Zhu, Atiyayein A Wallace, Andre J van Wijnen, Fackson Mwale, James C Iatridis, Daisuke Sakai, Gina Votta-Velis, Wen Yuan, Hee-Jeong Im
Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain. This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of low back pain can be divided into the following five categories: discogenic low back pain, radicular back pain, facet joint osteoarthritis back pain, muscle-induced low back pain, and spontaneous occurring low back pain models...
September 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28894388/bone-anchored-annular-closure-following-lumbar-discectomy-reduces-risk-of-complications-and-reoperations-within-90-days-of-discharge
#2
Peter Douglas Klassen, Derek Thomas Bernstein, Hans-Peter Köhler, Mark P Arts, Bradley Weiner, Larry E Miller, Claudius Thomé
PURPOSE: The purpose of this study was to evaluate perioperative complications of lumbar discectomy with or without bone-anchored annular closure device (ACD) implant in patients at high risk of recurrent disc herniation. METHODS: This was a post hoc analysis of a randomized controlled trial that compared outcomes of lumbar discectomy with or without additional placement of an ACD. Patients presented with imaging evidence of lumbar disc herniation and radicular pain that was unresponsive to conservative care...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28885649/l5-radiculopathy-secondary-to-migration-of-a-revision-stemmed-acetabular-cup
#3
Jesús Moreta, Oscar L Casado-Verdugo, Fernando Labayru
INTRODUCTION: Stemmed acetabular components are used in patients undergoing revision total hip arthroplasty in cases with major acetabular defects or pelvic discontinuity. Conflicting results relating to the survival of the component, and complication rates are reported in the literature. We present a case of L5 radiculopathy secondary to proximal migration of this device. CASE DESCRIPTION: A 79-year-old man was admitted to our department in 2012 with increasing pain and paresthesias, initially diagnosed as left L5 radiculopathy...
September 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28882526/extra-foraminal-microscopic-assisted-percutaneous-nucleotomy-for-foraminal-and-extraforaminal-lumbar-disc-herniations
#4
Ahmed Shawky, Dusko Babic, Ahmed Ezzat Siam, Ali Ezzati
Background Foraminal and extraforaminal lumbar disc herniations are uncommon. The main presentation is radicular pain related to the exiting nerve root at the affected level. Different approaches for surgical intervention have been described. Purpose To evaluate the clinical outcome, complications recurrence and reoperation rate of extraforaminal microscopic assisted percutaneous nucleotomy with literature review focusing on complications and recurrence rate Study Design Prospective cohort study done in a high flow spine center in Germany Patient Sample Between October 2012 and October 2015, 76 patients (35 females and 41 males) with foraminal or extraforaminal lumbar disc prolapse were operated upon...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28882525/multi-level-posterior-foraminotomy-with-laminoplasty-versus-laminoplasty-alone-for-cervical-spondylotic-myelopathy-with-radiculopathy-a-comparative-study
#5
Dong-Ho Lee, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Chunghwan Kim, Jung-Ki Ha
BACKGROUND CONTEXT: Conventional laminoplasty is useful for expanding a stenotic spinal canal. However, it has limited use for the decompression of accompanying neural foraminal stenosis. As such, an additional posterior foraminotomy could be simultaneously applied, although this procedure carries a risk of segmental kyphosis and instability. PURPOSE: The aim was to elucidate the long-term surgical outcomes of additional posterior foraminotomy with a laminoplasty for cervical spondylotic myelopathy (CSM) with radiculopathy...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28881117/comparison-of-root-images-between-post-myelographic-computed-tomography-and-magnetic-resonance-imaging-in-patients-with-lumbar-radiculopathy
#6
Chun-Kun Park, Hong-Jae Lee, Kyeong-Sik Ryu
OBJECTIVE: To evaluate the diagnostic value of computed tomography-myelography (CTM) compared to that of magnetic resonance imaging (MRI) in patients with lumbar radiculopathy. METHODS: The study included 91 patients presenting with radicular leg pain caused by herniated nucleus pulposus or lateral recess stenosis in the lumbar spine. The degree of nerve root compression on MRI and CTM was classified into four grades. The results of each imaging modality as assessed by two different observers were compared...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28871134/high-fat-diet-increases-pain-behaviors-in-rats-with-or-without-obesity
#7
Zongbin Song, Wenrui Xie, Sisi Chen, Judith A Strong, Mason S Print, Joy I Wang, Aleeya F Shareef, Yvonne M Ulrich-Lai, Jun-Ming Zhang
Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood. Using a milder version of a radicular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases in mechanical and cold allodynia in rats of both sexes that were maintained on a high-fat diet (HFD) for 6 weeks prior to DRG inflammation. Notably, this increase in pain-related behaviors occurred in both Long-Evans and Sprague-Dawley rats despite the fact that the 6-week HFD exposure induced obesity (e...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859023/isolated-third-cranial-nerve-palsy-leading-to-the-diagnosis-of-disseminated-burkitt-lymphoma-a-case-report-and-literature-review
#8
Arens Taga, Marco Russo, Irene Florindo, Giovanni Pavesi
INTRODUCTION: Dysfunction of the third cranial nerve can result from lesions anywhere along its course between the midbrain and the orbit. Lymphoma is a rare cause of isolated oculomotor nerve palsy (OMP), with only 19 cases reported in the literature. We describe a case of an isolated OMP leading to the diagnosis of disseminated Burkitt lymphoma (BL). CASE REPORT: A 37-year-old man presented with acute onset diplopia and right ptosis and was found to have a right pupillary sparing OMP...
September 2017: Neurologist
https://www.readbyqxmd.com/read/28857966/mini-open-lateral-retropleural-approach-for-symptomatic-thoracic-disk-herniations
#9
Chun-Po Yen, Juan S Uribe
BACKGROUND: Surgeries for symptomatic thoracic disk herniations (TDH) remain challenging. OBJECTIVE: A mini-open lateral retropleural approach is described and the clinical outcomes are reported. MATERIALS AND METHODS: A total of 23 patients underwent mini-open lateral retropleural diskectomy. Patients were placed in a lateral position. A 5-cm lateral incision was made followed by resection of the rib after careful dissection of its undersurface from the endothoracic fascia...
August 28, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28855219/dural-ectasia-associated-with-mounier-kuhn-syndrome-a-novel-association-in-the-context-of-spinal-stenosis
#10
Gerard Anthony Sheridan, Owen Godkin, Aiden Devitt
We present the case of a patient undergoing lumbar spine decompression for stenosis with a history of Mounier-Kuhn syndrome. The patient presented with axial lumbar spine pain over 6 months with progressive radicular pain to the left L3 dermatome. MRI confirmed spinal stenosis at L3/4 level with associated dural ectasia. The patient had an uneventful spinal decompression with resolution of radicular symptoms and axial spine pain. Dural ectasia poses a significant risk when operating on the lumbosacral spine...
August 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28854501/clinical-predictors-of-the-medical-interventions-provided-to-patients-with-low-back-pain-in-the-emergency-department
#11
David J Kohns, Andrew J Haig, Brad Uren, Katrina Diaz, Sierra Loar, David Share, Kerby Shedden, Mary Catherine Spires
BACKGROUND: Low back pain is a common complaint in emergency departments (ED), where deviations from standard of care have been noted. OBJECTIVE: To relate the ordering of advanced imaging and opioid prescriptions with the presentation of low back pain in ED. METHODS: Six hundred adults with low back pain from three centers were prospectively analyzed for history, examination, diagnosis, and the ordering of tests and treatments. RESULTS: Of 559 cases the onset of pain was less than one week in 79...
August 14, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28844618/impact-of-pain-and-pain-subtypes-on-the-quality-of-life-of-patients-with-parkinson-s-disease
#12
Seong-Min Choi, Byeong C Kim, Hyun-Jung Jung, Geum-Jin Yoon, Kyung Wook Kang, Kang-Ho Choi, Joon-Tae Kim, Seung-Han Lee, Man-Seok Park, Myeong-Kyu Kim, Ki-Hyun Cho
Pain is a frequent and troublesome non-motor symptom of Parkinson's disease (PD) and has a negative impact on quality of life (QoL). The aim of this study was to investigate the relative impact of pain or a specific pain subtype on the QoL of patients with PD. We included 161 patients with PD. Pain was assessed using the patients' descriptions, a structured interview, and a detailed neurological examination. QoL was assessed using the 39-item Parkinson's Disease Questionnaire (PDQ-39). One hundred and twenty (74...
August 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28798688/establishment-and-characterization-of-a-novel-rat-model-of-mechanical-low-back-pain-using-behavioral-pharmacologic-and-histologic-methods
#13
Arjun Muralidharan, Thomas S W Park, John T Mackie, Luiz G S Gimenez, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith
Chronic low back pain (LBP), the leading cause of disability globally, is notoriously difficult to treat. Most rodent models of LBP mimic lumbar radicular pain rather than mechanical LBP. Here, we describe establishment of a new rat model of mechanical LBP that is devoid of a neuropathic component. Groups of adult male Sprague Dawley rats were anesthetized and their lumbar L4/L5 and L5/L6 intervertebral disks (IVDs) were punctured (0.5 mm outer diameter, 2mm-deep) 5 (LPB-5X), or 10 (LBP-10X) times per disk...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28797833/percutaneous-rupture-of-zygapophyseal-joint-synovial-cysts-a-prospective-assessment-of-nonsurgical-management
#14
Gregory E Lutz, Michael R Nicoletti, George E Cyril, Julian R Harrison, Christopher Lutz, Jennifer L Solomon, Paul M Cooke, James F Wyss, Richard J Herzog, Peter J Moley
BACKGROUND: Although lumbar zygapophyseal joint synovial cysts are fairly well recognized, they are an uncommon cause of lumbosacral radicular pain. Non-operative treatments include percutaneous aspiration of the cysts under computed tomography or fluoroscopic guidance with a subsequent corticosteroid injection. However, there are mixed results in terms of long-term outcomes and cyst reoccurrence. This study prospectively evaluates percutaneous ruptures of zygapophyseal joint (Z-joint) synovial cysts for the treatment of lumbosacral radicular pain...
August 7, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28796547/do-superior-or-inferior-interlaminar-approach-or-bevel-orientation-predispose-to-nonepidural-needle-penetration
#15
Nicholas A Koontz, Richard H Wiggins, Gregory J Stoddard, Lubdha M Shah
OBJECTIVE: There is a paucity of evidence-based literature regarding the advantages and disadvantages of the interlaminar approach and needle bevel orientation for performing a lumbar interlaminar epidural steroid injection (ESI). The purpose of this study was to determine if superior versus inferior lamina approach, needle bevel tip orientation, or both may predispose to inadvertent nonepidural penetration during lumbar interlaminar ESI. SUBJECTS AND METHODS: A prospective study was performed of patients with low back pain with or without radicular pain or neurogenic claudication referred for lumbar interlaminar ESI...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28770554/the-clinical-comparison-between-the-patients-operated-for-unilateral-radiculopathy-via-contralateral-facet-sparing-and-ipsilateral-side-approach
#16
Ahmet Öğrenci, Orkun Koban, Onur Yaman, Mesut Yilmaz, Sedat Dalbayrak
AIM: To compare clinical outcomes of the patients operated from the contralateral or ipsilateral side for unilateral radiculopathy in spinal stenosis. MATERIAL AND METHODS: This was a retrospective study. Twenty patients were listed as Group 1 (Contralateral) with unilateral radiculopathy and spinal stenosis with/without lateral recess syndrome or foraminal stenosis. Decompression from opposite side of radiculopathy was performed to Group 1 patients. Decompression from the radiculopathy side was performed to the patients in Group 2 (Ipsilateral)...
June 20, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28764746/percutaneous-endoscopic-lumbar-discectomy-minimally-invasive-technique-for-multiple-episodes-of-lumbar-disc-herniation
#17
Kyung-Chul Choi, Jin-Sung Kim, Dong Chan Lee, Choon-Keun Park
BACKGROUNDS: Although open lumbar discectomy is a gold standard surgical technique for lumbar disc herniation (LDH), surgery-induced tissue injury may actually become a source of postsurgical pain. Percutaneous endoscopic lumbar discectomy (PELD) is introduced as a minimal invasive spinal technique for LDH. The PELD has gained popularity and shown successful results. The authors report the clinical usefulness of the PELD technique in two patients with the serial multilevel LDHs. CASE PRESENTATIONS: A 32-year-old man suffered from radicular pain at the L5 dermatome due to the down migrated soft LDH at the L4-5 level...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28735135/endoscope-assisted-abscess-drainage-secondary-to-endoscope-assisted-tlif-1-year-follow-up
#18
Karthik Madhavan, Steven Shelby Burks, Lee Onn Chieng, Anand Veeravagu, Michael Y Wang
INTRODUCTION: Endoscopic discectomy and fusions have been gaining popularity in the recent past and are noted to be safe for its application in elderly population. It involves ultra-small incision for discectomy followed by placement of percutaneous screws in awake patients. Treatment of advanced spinal pathology using endoscope-assisted techniques are challenging. Although not common with endoscopic approach, post-operative infection can be problematic as there are no established guidelines on its management...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28731977/interventions-for-neuropathic-pain-an-overview-of-systematic-reviews
#19
REVIEW
Svjetlana Dosenovic, Antonia Jelicic Kadic, Maja Miljanovic, Marina Biocic, Krste Boric, Marija Cavar, Nikolina Markovina, Katarina Vucic, Livia Puljak
Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Study quality was analyzed using A Measurement Tool to Assess Systematic Reviews. The most common interventions in 97 included SRs were pharmacologic (59%) and surgical (15%). The majority of analyzed SRs were of medium quality...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28713631/percutaneous-cervical-laser-diskectomy-thermoannuloplasty-and-thermonucleoplasty-comparable-results-without-surgery
#20
EDITORIAL
Nancy E Epstein
BACKGROUND: Utilizing the literature, the results of three different minimally invasive surgery (MIS) anterior cervical percutaneous operations for neck/mild radicular pain and magnetic resonance (MR)-documented "contained" (not extruded/sequestrated) discs were evaluated. Results were compared with patients treated nonsurgically for comparable/greater neurological compromise, and even more severe cervical disc disease. METHODS: There were three MIS percutaneous anterior cervical discectomy procedures...
2017: Surgical Neurology International
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