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https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#1
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29322966/the-influence-of-adjunctive-caudal-epidural-steroid-injection-on-the-therapeutic-effect-of-transforaminal-epidural-steroid-injection
#2
Atilla Kircelli, Tufan Cansever, Cem Yılmaz
BACKGROUND: Epidural steroid injection is widely used to treat the short and long-term symptoms of low back and radicular pain. To the best of our knowledge, the influence of transforaminal epidural steroid injection (TFSI) combined with caudal epidural steroid injection (CESI) on pain intensity, patient satisfaction, and quality of life in lumbar radiculopathy has not been examined. AIM: To evaluate the short and long-term efficacy of TFSI, and TFSI combined with CESI (TFSI + CESI) in patients with lumbar radiculopathy...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322309/the-global-spine-care-initiative-a-summary-of-guidelines-on-invasive-interventions-for-the-management-of-persistent-and-disabling-spinal-pain-in-low-and-middle-income-communities
#3
REVIEW
Emre Acaroğlu, Margareta Nordin, Kristi Randhawa, Roger Chou, Pierre Côté, Tiro Mmopelwa, Scott Haldeman
PURPOSE: The purpose of this study was to synthesize recommendations on the use of common elective surgical and interventional procedures for individuals with persistent and disabling non-radicular/axial with or without myelopathy, radicular back pain, cervical myelopathy, symptomatic spinal stenosis, and fractures due to osteoporosis. This review was to inform a clinical care pathway on the patient presentations where surgical interventions could reasonably be considered. METHODS: We synthesized recommendations from six evidence-based clinical practice guidelines and one appropriate use criteria guidance for the surgical and interventional management of persistent and disabling spine pain...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29318337/full-endoscopic-posterior-foraminotomy-surgery-for-cervical-disc-herniations
#4
REVIEW
M Komp, S Oezdemir, P Hahn, S Ruetten
OBJECTIVE: Surgery for cervical disc herniation with full-endoscopic posterior access. INDICATIONS: Cervical disc herniation and neuroforaminal pathology with radicular symptoms. CONTRAINDICATIONS: Neck pain alone, cervical myelopathy or pathologies with central nervous system symptoms, instabilities requiring correction/instabilities. SURGICAL TECHNIQUE: Introduction of a surgical tube to the facet joint at the level to be operated on...
January 9, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29290136/a-novel-noninstrumented-surgical-approach-for-foramen-reconstruction-for-isthmic-spondylolisthesis-in-patients-with-radiculopathy-preliminary-clinical-and-radiographic-outcomes
#5
Jochem K H Spoor, Alof H G Dallenga, Pravesh S Gadjradj, Luuk de Klerk, Frans C van Biezen, Henk W C Bijvoet, Biswadjiet S Harhangi
OBJECTIVE The health care costs for instrumented spine surgery have increased dramatically in the last few decades. The authors present a novel noninstrumented surgical approach for patients with isthmic spondylolisthesis, with clinical and radiographic results. METHODS Charts of patients who underwent this technique were reviewed. The procedure consisted of nerve root decompression by reconstruction of the intervertebral foramen. This was achieved by removal of the pedicle followed by noninstrumented posterolateral fusion in which autologous bone graft from the right iliac crest was used...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29288847/decision-making-for-the-surgical-treatment-of-vertebral-metastases-among-patients-with-short-predicted-survival
#6
Triantafyllos Bouras, Fahed Zairi, Ala Arikat, Marie-Hélène Vieillard, Mohamed Allaoui, Richard Assaker
BACKGROUND: A wide spectrum of treatment choices is proposed for poor-prognosis patients with vertebral metastases. The continuous increase of this population and the propagation of less invasive techniques necessitate further study concerning which patients could benefit from palliative surgery. METHODS: All patients with a Tokuhashi score ≤ 8 undergone palliative surgical treatment for vertebral metastasis within four years were retrospectively reviewed. Demographics, clinical parameters, and data concerning the disease and the operation were recorded...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29273659/pted-study-design-of-a-non-inferiority-randomised-controlled-trial-to-compare-the-effectiveness-and-cost-effectiveness-of-percutaneous-transforaminal-endoscopic-discectomy-pted-versus-open-microdiscectomy-for-patients-with-a-symptomatic-lumbar-disc-herniation
#7
Ankie Seiger, Pravesh S Gadjradj, Biswadjiet S Harhangi, Job Lc van Susante, Wilco C Peul, Maurits W van Tulder, Michiel R de Boer, Sidney M Rubinstein
INTRODUCTION: Lumbosacral radicular syndrome is often caused by a disc herniation. The standard surgical technique to remove a disc herniation is open microdiscectomy. An alternative technique is percutaneous transforaminal endoscopic discectomy (PTED), which is less invasive. In the Netherlands, PTED is not currently considered as standard care, and therefore not reimbursed within public health insurance. A pragmatic, multicentre, non-inferiority, randomised controlled trial has been designed to determine the effectiveness and cost-effectiveness of PTED versus open microdiscectomy for the treatment of lumbar disc herniation...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29244686/high-thoracic-disc-herniation-causing-horner-syndrome-with-the-intraoperative-finding-of-conjoined-nerve-root-compression-a-case-report
#8
Amit K Bhandutia, Zachary Zuzek, Matthew J Schessler, Nestor D Tomycz, Daniel T Altman
CASE: A 29-year-old man presented with right medial arm pain with paresthesia, as well as right-sided ptosis, miosis, and anhidrosis. Magnetic resonance imaging revealed a right paracentral disc herniation at the T1-T2 level. The patient underwent a hemilaminectomy with a medial facetectomy through a posterolateral approach to the T1-T2 disc space, followed by a discectomy. Intraoperative findings were notable for a conjoined nerve root. CONCLUSION: Although high thoracic disc herniation is rare, its diagnosis should be considered when patients present with radicular arm pain and Horner syndrome...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29233749/an-amendment-to-the-neidre-and-macnab-classification-system-for-lumbosacral-nerve-root-anomaly-and-its-implication-in-percutaneous-endoscopic-lumbar-discectomy
#9
Chen Yu, Chang Zhengqi, Yu Xiuchun
BACKGROUND: Lumbar disc herniation complicated with nerve root anomaly presents great challenges to diagnosis and treatment, improper selection of surgical procedures may cause inferior outcomes and neurological injury. CASE DESCRIPTION: A 66-year old male presented with low back pain and radicular symptoms involving bilateral L-5 and S-1 nerve roots. Instead of percutaneous endoscopic lumbar discectomy, aggressive decompression was carried out due to deviation between examination and imaging findings...
December 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29202816/the-treatment-of-migraine-patients-within-chiropractic-analysis-of-a-nationally-representative-survey-of-1869-chiropractors
#10
Craig Moore, Jon Adams, Andrew Leaver, Romy Lauche, David Sibbritt
BACKGROUND: While the clinical role of manual therapies in migraine management is unclear, the use of chiropractors for this condition is considerable. The aim of this study is to evaluate the prevalence and characteristics of chiropractors who frequently manage patients with migraine. METHODS: A national cross-sectional survey of chiropractors collected information on practitioner characteristics, clinical management characteristics and practice settings. A secondary analysis was conducted on 1869 respondents who reported on their migraine caseload to determine the predictors associated with the frequent management of patients with migraine...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29189309/lumbar-transforaminal-epidural-steroid-injection-in-patients-with-chronic-unilateral-radicular-pain
#11
Tomoyuki Kawada
No abstract text is available yet for this article.
November 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29189307/lumbar-transforaminal-epidural-steroid-injection-in-patients-with-chronic-unilateral-radicular-pain
#12
Harald Ekedahl, Bo Jönsson, Richard B Frobell
No abstract text is available yet for this article.
November 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29179752/characteristics-and-determinants-of-clinical-symptoms-in-radiographic-lumbar-spinal-stenosis-in-a-tertiary-health-care-centre-in-sub-saharan-africa
#13
Marie Doualla-Bija, Mbeng Ashu Takang, Emmanuella Mankaa, Jude Moutchia, Pierre Ongolo-Zogo, Henry Luma-Namme
BACKGROUND: Lumbar spinal stenosis (LSS) refers to narrowing of the lumbar central spinal canal, lateral recess, and/or neuro-foramina. Radiographic LSS plays an important role in clinical LSS but is not solely accountable for the presence of symptoms. We sought to characterise clinical LSS and to determine factors associated with presence of symptoms of LSS in patients with radiographic LSS in a sub Saharan Africa setting. METHODS: After prior ethical clearance, a case control study was done in a tertiary hospital in Douala-Cameroon, including 105 patients with radiographic LSS: 57 with symptoms of LSS (cases) and 58 with no symptoms (controls)...
November 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29177632/the-use-of-lumbar-epidural-injection-of-platelet-lysate-for-treatment-of-radicular-pain
#14
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Matthew Hyzy, Christopher Williams, Michael Freeman
BACKGROUND: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids. METHODS: Registry data was obtained for patients (N = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms...
November 25, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29173666/lumbar-epidural-steroid-injections
#15
REVIEW
Carlos E Rivera
Lumbar epidural steroid injections under fluoroscopic guidance are used very commonly for the treatment of low back and lower extremity radicular pain. These procedures have been shown to be effective for pain relief in the short term and are relatively safe. The indications, evidence, and safety considerations for 2 different techniques-namely, interlaminar and transforaminal-are discussed.
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29173656/cervical-epidural-steroid-injection-techniques-and-evidence
#16
REVIEW
Lawrence McLean House, Kevin Barrette, Ryan Mattie, Zachary L McCormick
Cervical epidural steroid injections are a common treatment of cervical radicular pain. Important safety considerations include attention to the possibility of spinal cord infarction and spinal epidural hematoma. When appropriate, radiographic, technical, and pharmacologic principals are used, these procedures are relatively safe. Cervical epidural steroid injections are effective for the short-term treatment of radicular pain. More rigorously designed clinical outcomes studies of both cervical interlaminar and transforaminal epidural steroid injections are needed...
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29170340/43%C3%A2-management-of-acute-low-back-pain-in-the-ed-a-systematic-review
#17
Jane Ashbrook, Nikos Rodgdakis, Peter Goodwin, Gill Yeowell, Michael Callaghan
STUDY OBJECTIVE: There is no consensus on the management of low back pain in the ED and evidence suggests that these patients are likely to receive unwarranted imaging and inappropriate opioid prescription.The purpose of this study is to review the available literature pertaining to the clinical management of acute low back pain in the ED. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) guidelines were observed during this review...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29157725/nonsurgical-lumbar-radiculopathies-treated-with-ultramicronized-palmitoylethanolamide-umpea-a-series-of-100-cases
#18
Domenico Chirchiglia, Pasquale Chirchiglia, Francesco Signorelli
In this clinical/observational study we have reported the administration of Palmitoylethanolamide (PEA) in patients suffering from radicular lumbar spinal pathology, who had no indication for surgical treatment. We analyzed a series of 100 cases retrospectively, all undergoing clinical and diagnostic investigations, which had shown the presence of abnormalities of the vertebral body and intervertebral discs, mainly degenerative, such as spondyloarthrosis, spondylo-discarthrosis, disc protrusion, excluding disc herniation, which fell within surgical cases...
November 14, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29149147/hypothalamic-pituitary-adrenocortical-axis-suppression-following-a-single-epidural-injection-of-methylprednisolone-acetate
#19
Aleem Jameel Abdul, Babita Ghai, Dipika Bansal, Naresh Sachdeva, Anil Bhansali, Saravdeep Singh Dhatt
BACKGROUND: Epidural injections (EIs) are the most commonly performed minimally invasive intervention in managing chronic low back pain (CLBP). There is inconsistency in data to accurately predict the degree of hypothalamic-piuitary-adrenal (HPA) axis suppression in patients receiving exogenous steroid therapy, especially in the form of epidural steroid injections (ESIs). OBJECTIVE: We aim to quantify the degree and duration of HPA axis suppression after a single ESI of 80 mg methyl prednisolone acetate in patients with CLBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149145/endoscopic-epidural-laser-decompression-versus-transforaminal-epiduroscopic-laser-annuloplasty-for-lumbar-disc-herniation-a-prospective-randomized-trial
#20
Chang Hong Park, Sang Ho Lee
BACKGROUND: Lumbar radicular pain often results from lumbar disc herniation, spinal stenosis, or degenerative spondylolisthesis. Minimally invasive disc decompression procedures, such as nucleo-annuloplasty or epiduroscopic neural decompression by laser, have been devised to treat such pain. OBJECTIVE: The short-term outcomes of disc decompression by endoscopic epidural laser decompression (EELD) or transforaminal epiduroscopic laser annuloplasty (TELA) were compared in patients with lumbar radicular pain due to disc herniation...
November 2017: Pain Physician
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