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https://www.readbyqxmd.com/read/27926938/uncovering-the-pathogenic-landscape-of-helminth-opisthorchis-viverrini-infections-a-cross-sectional-study-on-contributions-of-physical-and-social-environment-and-healthcare-interventions
#1
Xueyuan Ong, Yi-Chen Wang, Paiboon Sithithaworn, Jutamas Namsanor, David Taylor, Luxana Laithavewat
BACKGROUND: Helminth infections have proven recalcitrant to control by chemotherapy in many parts of Southeast Asia and indeed farther afield. This study isolates and examines the influence of different aspects of the physical and social environment, and uneven intervention effort contributing to the pathogenic landscape of human Opisthorchis viverrini infections. METHODOLOGY: A cross-sectional survey, involving 632 participants, was conducted in four villages in northeast Thailand to examine the impact on prevalence and parasite burden of the reservoir dam environment, socio-economic, demographic, and behavioral factors, and health center intervention efforts...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27926786/nut-midline-carcinoma-of-the-larynx-an-international-series-and-review-of-the-literature
#2
Henrik Hellquist, Christopher A French, Justin A Bishop, Andrés Coca-Pelaz, Evan J Propst, António Paiva Correia, Bo-Yee Ngan, Ronald Grant, Nicole A Cipriani, David Vokes, Rui Henrique, Fernando Pardal, Jose Ramon Vizcaino, Alessandra Rinaldo, Alfio Ferlito
AIMS: NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that characteristically locates to the midline of the head and neck, and mediastinum. NMC is characterised by chromosomal rearrangements of the gene encoding nuclear protein in testis, NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion oncogene, BRD4-NUT. By the end of 2014, the International NUT Midline Carcinoma Registry had 48 patients treated for NMC. Laryngeal NMC are exceedingly rare and we report a case series of seven cases...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926778/met-tyrosine-kinase-receptor-expression-and-amplification-as-prognostic-biomarkers-of-survival-in-gastroesophageal-adenocarcinoma
#3
Daniel V T Catenacci, Agnes Ang, Wei-Li Liao, Jing Shen, Emily O'Day, Robert D Loberg, Fabiola Cecchi, Todd Hembrough, Annamaria Ruzzo, Francesco Graziano
BACKGROUND: MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), respectively. Targeted proteomics uses mass spectrometry-based selected reaction monitoring (SRM) to accurately quantitate Met expression. FISH, IHC, and SRM analyses were compared to characterize the prognostic value of MET/Met in gastroesophageal adenocarcinoma (GEC)...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27926424/plug-closure-of-an-arteriovenous-fish-tula-for-lymphedema
#4
Pua Uei, Glenn Wei Leong Tan
No abstract text is available yet for this article.
November 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27925299/biomimicking-of-a-swim-bladder-and-its-application-as-a-mini-generator
#5
Mengmeng Song, Mengjiao Cheng, Meng Xiao, Lina Zhang, Guannan Ju, Feng Shi
A model fish with man-made swim bladder achieves fast vertical motions based on density adjustments in a pressure-responsive way. When exposed to a magnetic field, a mini-generator is achieved by harvesting energy from the environment, working with pressure differences in the blood pressure range and at the frequency of a beating heart.
December 7, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27925269/lifecycle-exposure-of-fathead-minnows-to-environmentally-relevant-concentrations-of-the-%C3%AE-blocker-drug-propranolol
#6
Joanne L Parrott, Vimal K Balakrishnan
Propranolol is a human pharmaceutical β-blocker that has been detected in municipal wastewater effluents at ng/L to low µg/L. To assess the potential of this compound to affect fish, fathead minnow (Pimephales promelas) were exposed for a lifecycle in a flow-through system to nominal propranolol concentrations of 0.87, 8.7, 87, 870 and 8,700 ng/L. Measured propranolol concentrations were below detection for the two lowest exposure concentrations, and were 76, 580, and 7,800 ng/L for the three highest exposure concentrations...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27925173/potential-of-long-non-coding-rnas-in-cancer-patients-from-bio-markers-to-therapeutic-targets
#7
REVIEW
Subash Chandra Gupta, Yashoda Nandan Tripathi
Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a bio-marker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer, and many other cancer types. Some lncRNAs have also been used as adjunct to improve the specificity and sensitivity of existing biomarkers. The molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE and quantitative real-time PCR have been used for examining the lncRNAs' potential...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27925141/nutritional-interventions-that-slow-the-age-associated-decline-in-renal-function-in-a-canine-geriatric-model-for-elderly-humans
#8
J A Hall, M Yerramilli, E Obare, M Yerramilli, K S Panickar, G Bobe, D E Jewell
OBJECTIVE: To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model. DESIGN: Randomized block design and cross-sectional study. SETTING: Hill's Pet Nutrition, Inc. dog colony. PARTICIPANTS: Eighty-one geriatric dogs (mean age, 10...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27925070/first-study-on-communities-of-parasites-in-triportheus-rotundatus-a-characidae-fish-from-the-amazon-river-system-brazil
#9
Paulo Henrique Nascimento Santos, Marcos Tavares-Dias
This study was the first investigation on the parasites of Triportheus rotundatus, a Characiformes fish from the Amazon, in Brazil. All the fish collected (100%) in a tributary from the Amazon River system were infected by one or more parasite species. The mean species richness of parasites was 4.9 ± 0.9, the Brillouin index was 0.39 ± 0.16, the evenness was 0.24 ± 0.09 and the Berger-Parker dominance was 0.81 ± 0.13. A total of 1316 metazoan parasites were collected, including Anacanthorus pithophallus, Anacanthorus furculus, Ancistrohaptor sp...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27925000/optimization-of-artificial-propagation-in-piracanjuba-fish-brycon-orbignyanus-using-cryopreserved-semen
#10
V O Felizardo, C C V Melo, L D S Murgas, E S Andrade, R D Navarro, T F Ftreitas
:   BACKGROUND: Cryopreserved semen could facilitate procedures during the artificial reproduction in fish. Factors affecting cryopreservation efficiency are important to define efficient protocols. OBJECTIVE: This study investigated the application of cryoprotectants on the quality of piracanjuba fish semen, the sperm concentration required for oocyte fertilization and spermatic activation. MATERIALS AND METHODS: We evaluated two intracellular cryoprotectant solutions (DMSO and methanol) and two extracellular cryoprotectant solutions (egg yolk and lactose) to cryopreserved piracanjuba semen...
September 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924671/the-effect-of-the-additional-cytogenetic-abnormalities-on-major-molecular-response-and-bcr-abl-kinase-domain-mutations-in-long-term-follow-up-chronic-myeloid-leukemia-patients-a-cross-sectional-study
#11
Kaan Savasoglu, Kadriye Bahriye Payzin, Fusun Ozdemirkiran, Asli Subasioglu, Asu Fergun Yilmaz
The aim of the study was to examine the relation between additional chromosomal aberrations (ACAs) with major molecular response (MMR) and BCR-ABL kinase domain (KD) mutations in the long-term follow-up of the chronic myeloid leukemia (CML) disease. The study design was cross-sectional observational and used the CML patients' data of Izmir Ataturk Education and Research Hospital from 2011 to 2015. Conventional cytogenetic, fluorescence in situ hybridization (FISH), quantitative real-time polymerase chain reaction (RQ-PCR) test results from 89 CML patients' and pyrosequencing analysis results from 17 patients' were set up for comparison analysis...
December 7, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27924249/gastrointestinal-anisakidosis-watch-what-you-eat
#12
Moiz Ahmed, Faez Ayoob, Mayurathan Kesavan, Vivek Gumaste, Ambreen Khalil
Gastrointestinal anisakidosis is an under-reported and often misdiagnosed parasitic infection caused by the larvae of a nematode anisakis. The majority of cases are seen in Japan due to the consumption of raw and undercooked seafood; however, the incidence is likely to rise in the United States given the rising popularity of Japanese cuisine like sashimi or sushi. This unique report highlights the importance of considering anisakiasis in the differential diagnoses for patients with nonspecific abdominal symptoms with a recent history of raw or undercooked fish consumption...
November 2, 2016: Curēus
https://www.readbyqxmd.com/read/27924152/molecular-characterization-of-a-rare-analphoid-supernumerary-marker-chromosome-derived-from-7q35%C3%A2-%C3%A2-%C3%A2-qter-a-case-report
#13
Bárbara Marques, Cristina Ferreira, Filomena Brito, Sónia Pedro, Cristina Alves, Teresa Lourenço, Marta Amorim, Hildeberto Correia
BACKGROUND: Analphoid supernumerary marker chromosomes (aSMC) constitute one of the smallest groups of SMC, and are characterized by a centromeric constriction but no detectable alpha-satellite DNA. These marker chromosomes cannot be properly identified by conventional banding techniques alone, and molecular cytogenetic methods are necessary for a detailed characterization. Analphoid SMC derived from chromosome 7 are extremely rare, with only five cases reported so far. CASE PRESENTATION: In this work we report an aSMC involving the terminal long arm of chromosome 7 in a 10-year-old boy with multiple dysmorphic features and severe development delay...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/27924059/an-open-label-phase-ii-study-evaluating-first-line-egfr-tyrosine-kinase-inhibitor-erlotinib-in-non-small-cell-lung-cancer-patients-with-tumors-showing-high-egfr-gene-copy-number
#14
Ewa Szutowicz-Zielińska, Krzysztof Konopa, Anna Kowalczyk, Małgorzata Suszko-Każarnowicz, Renata Duchnowska, Aleksandra Szczęsna, Magdalena Ratajska, Aleksander Sowa, Janusz Limon, Wojciech Biernat, Tomasz Burzykowski, Jacek Jassem, Rafał Dziadziuszko
BACKGROUND: First-line treatment with epidermal growth factor receptor (EGFR) inhibitors in NSCLC is effective in patients with activating EGFR mutations. The activity of erlotinib in patients harboring high EGFR gene copy number has been considered debatable. PATIENTS AND METHODS: A multicenter, open-label, single-arm phase II clinical trial was performed to test the efficacy of erlotinib in the first-line treatment of NSCLC patients harboring high EGFR gene copy number defined as ≥4 copies in ≥40% of cells...
December 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923910/a-new-approach-to-chromosomal-evolution-in-the-giant-water-bug-heteroptera-belostomatidae
#15
Raquel Bozini Gallo, Rachel Colauto Milanezi Aguiar, Ana Paula Scaramal Ricietto, Laurival Vilas-Boas, Carlos Roberto Maximiano da Silva, José Ricardo Inacio Ribeiro, Renata Da Rosa
The genus Belostoma, known colloquially as 'giant water bugs', presents striking cytogenetic diversity and extensive chromosome variability. Notwithstanding, its karyotype evolution is not well understood. We analyzed eight species of Belostoma (77 samples). The meiotic analysis revealed 2n=14+XY for B. horvathi and B. candidulum; 2n=22+XY for B. cummings; 2n=26+X1X2Y for B. dentatum, B. elongatum, and B. discretum; and 2n=26+X1X2X3Y for B. testacopallidum and B. dilatatum. All species showed holokinetic chromosomes...
December 6, 2016: Journal of Heredity
https://www.readbyqxmd.com/read/27923746/aeromonas-salmonicida-type-iii-secretion-system-effectors-mediated-immune-suppression-in-rainbow-trout-oncorhynchus-mykiss
#16
F C Origgi, O Benedicenti, H Segner, U Sattler, T Wahli, J Frey
Aeromonas salmonicida subsp. salmonicida, the etiologic agent of furunculosis, is a major pathogen in aquaculture. Together with other pathogens, it is characterized by the presence of a type 3 secretion system (T3SS). The T3SS is the main virulence mechanism of A. salmonicida. It is used by the bacterium to secrete and translocate several toxins and effector proteins into the host cell. Some of these factors have a detrimental impact on the integrity of the cell cytoskeleton, likely contributing to impair phagocytosis...
December 3, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27923711/characterization-of-na-transport-to-gain-insight-into-the-mechanism-of-acid-base-and-ion-regulation-in-white-sturgeon-acipenser-transmontanus
#17
Ryan B Shartau, Kevin V Brix, Colin J Brauner
Freshwater fish actively take up ions via specific transporters to counter diffusive losses to their hypotonic environment. While much is known about the specific mechanisms employed by teleosts, almost nothing is known about the basal fishes, such as white sturgeon (Acipenser transmontanus) which may offer insight into the evolution of osmo- and ionoregulation in fishes. We investigated Na(+) uptake in juvenile white sturgeon in the presence and absence of transporter inhibitors. We found that sturgeon acclimated to 100μmol 1(-1) Na(+) have Na(+) uptake kinetics typical of teleosts and that a Na(+)/H(+) exchanger (NHE) is the predominant transporter for Na(+) uptake...
December 3, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27923506/using-silver-and-bighead-carp-cell-lines-for-the-identification-of-a-unique-metabolite-fingerprint-from-thiram-specific-chemical-exposure
#18
Joel G Putnam, Justine E Nelson, Eric M Leis, Richard A Erickson, Terrance D Hubert, Jon J Amberg
Conservation biology often requires the control of invasive species. One method is the development and use of biocides. Identifying new chemicals as part of the biocide registration approval process can require screening millions of compounds. Traditionally, screening new chemicals has been done in vivo using test organisms. Using in vitro (e.g., cell lines) and in silico (e.g., computer models) methods decrease test organism requirements and increase screening speed and efficiency. These methods, however, would be greatly improved by better understanding how individual fish species metabolize selected compounds...
December 3, 2016: Chemosphere
https://www.readbyqxmd.com/read/27923499/validation-of-34betae12-immunoexpression-in-clear-cell-papillary-renal-cell-carcinoma-as-a-sensitive-biomarker
#19
Guido Martignoni, Matteo Brunelli, Diego Segala, Enrico Munari, Stefano Gobbo, Luca Cima, Ioana Borze, Tina Wirtanen, Virinder Kaur Sarhadi, Lilit Atanesyan, Suvi Savola, Luisa Barzon, Giulia Masi, Matteo Fassan, John N Eble, Tom Bohling, Liang Cheng, Brett Delahunt, Sakari Knuutila
Clear cell papillary renal cell carcinoma (CCPRCC) is a recently recognised neoplasm with a broad spectrum of morphological characteristics, thus representing a challenging differential diagnosis, especially with the low malignant potential multicystic renal cell neoplasms and clear cell renal cell carcinoma. We selected 14 cases of CCPRCC with a wide spectrum of morphological features diagnosed on morphology and CK7 immunoreactivity and analysed them using a panel of immunohistochemical markers, focusing on 34βE12 and related CKs 1,5,10 and 14 and several molecular analyses such as fluorescence in situ hybridisation (FISH), array comparative genomic hybridisation (aCGH), VHL methylation, VHL and TCEB1 sequencing and multiplex ligation-dependent probe amplification (MLPA)...
December 3, 2016: Pathology
https://www.readbyqxmd.com/read/27923466/predicting-lethal-entanglements-as-a-consequence-of-drag-from-fishing-gear
#20
Julie M van der Hoop, Peter Corkeron, Allison G Henry, Amy R Knowlton, Michael J Moore
Large whales are frequently entangled in fishing gear and sometimes swim while carrying gear for days to years. Entangled whales are subject to additional drag forces requiring increased thrust power and energy expenditure over time. To classify entanglement cases and aid potential disentanglement efforts, it is useful to know how long an entangled whale might survive, given the unique configurations of the gear they are towing. This study establishes an approach to predict drag forces on fishing gear that entangles whales, and applies this method to ten North Atlantic right whale cases to estimate the resulting increase in energy expenditure and the critical entanglement duration that could lead to death...
December 3, 2016: Marine Pollution Bulletin
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