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Uterine metabolism

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https://www.readbyqxmd.com/read/29661800/chorionic-somatomammotropin-impacts-early-fetal-growth-and-placental-gene-expression
#1
Kimberly M Jeckel, Alexander C Boyarko, Gerrit Bouma, Quinton Winger, Russ V Anthony
Several developmental windows, including placentation, must be negotiated to establish and maintain pregnancy. Impaired placental function can lead to pre-eclampsia and/or intrauterine growth restriction (IUGR), resulting in increased infant mortality and morbidity. It has been hypothesized that chorionic somatomammotropin (CSH), plays a significant role in fetal development, potentially by modifying maternal and fetal metabolism. Recently, using lentiviral-mediated in vivo RNA interference in sheep, we demonstrated significant reductions in near-term (135 days of gestation; dGA) fetal and placental size, and altered fetal liver gene expression, resulting from CSH deficiency...
April 16, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29659523/antibacterial-efficacy-of-silver-nanoparticles-on-endometritis-caused-by-prevotella-melaninogenica-and-arcanobacterum-pyogenes-in-dairy-cattle
#2
Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim
Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29620641/expression-and-prognostic-value-of-lactate-dehydrogenase-a-and-d-subunits-in-human-uterine-myoma-and-uterine-sarcoma
#3
Ke-Juan Song, Xiao-Ni Yu, Teng Lv, Yu-Long Chen, Yu-Chao Diao, Su-Li Liu, Yan-Kui Wang, Qin Yao
OBJECTIVE: This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance. METHODS: Protein expression levels of LDH-A and LDH-D were determined in tissue samples from 86 patients (26 uterine myoma, 10 CLM, 50 uterine sarcoma) by immunohistochemistry and their associations with clinicopathologic parameters and outcomes were analyzed in patients with uterine sarcoma...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29597123/systemic-profiling-of-ectopic-fat-deposits-in-the-reproductive-tract-of-dairy-cows
#4
Martina Crociati, Flavio Di Giacinto, Elisabetta Manuali, Giuseppe Stradaioli, Lakamy Sylla, Maurizio Monaci, Giuseppe Maulucci, Marco De Spirito
During the transition period, high-yielding dairy cows suffer from negative energy balance, intense lipomobilization and impaired lipid metabolism; this metabolic condition can lead to overburdened triglycerides accumulation in the liver, known as liver lipidosis, which has been associated to impaired fertility in dairy cows. The mechanisms of this impairment can be in principle correlated with the presence and the extent of ectopic fat depots. However, current methods for evaluating fat accumulation in liver and in the reproductive tract suffer from low resolution, sensitivity, and specificity...
March 17, 2018: Theriogenology
https://www.readbyqxmd.com/read/29595104/association-of-metronidazole-with-cancer-a-potential-risk-factor-or-inconsistent-deductions
#5
Muhammad Adil, Waheed Iqbal, Fazal Adnan, Shabnam Wazir, Imran Khan, Mohammad Umar Khayam, Mohammad Amjad Kamal, Shafiq Ahmad, Jawad Ahmad, Ishaq N Khan
Metronidazole is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and protozoal parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, acute ulcerative gingivitis, syphilis and tropical phagedena. In addition to its toxicity in the gastrointestinal tract and central/peripheral nervous system, metronidazole has been reported to cause mucosal imbalance by affecting the expression of mucin (Muc2 gene), which is responsible to form an insoluble mucous barrier that protects the gut lumen from microbial colonization...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29573521/activation-of-the-igf1-receptor-stimulates-glycogen-synthesis-by-mink-uterine-epithelial-cells
#6
Matthew Dean, Jack Rose
Glycogen synthesis by mink uterine epithelial cells is stimulated by estradiol (E2 ) during estrus, although the mechanism/s through which the steroid promotes glycogen accumulation are unknown. Our aim was to determine if insulin is required for E2 induced glycogen synthesis by an immortalized mink uterine epithelial cell line (GMMe). We show that the cells expressed the genes for glycogen metabolizing enzymes (hexokinase 1, glucose-6-phosphatase 3, glycogen synthase 1 and glycogen phosphorylase-muscle), receptors for insulin, insulin-like growth factor 1 and E2 (Esr1)...
March 24, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29569542/innate-differences-and-colostrum-induced-alterations-of-jejunal-mucosal-proteins-in-piglets-with-intra-uterine-growth-restriction
#7
Xiaoqiu Wang, Yuhua Zhu, Cuiping Feng, Gang Lin, Guoyao Wu, Defa Li, Junjun Wang
Mammalian neonates undergo rapid transitions from a sterile uterine environment with a continuous intravenous supply of nutrients to a microbe-rich environment with intermittent ingesting of colostrum/milk via the gut. Currently, little is known about the colostrum-induced alterations of intestinal mucosal proteins in piglets with intra-uterine growth restriction (IUGR). In this study, we sought to investigate the innate differences and effects of colostrum on alterations in small-intestinal proteomes of IUGR piglets...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29560763/pre-and-peripartal-management-of-a-woman-with-mcardle-disease-a-case-report
#8
Tina Stopp, Michael Feichtinger, Wolfgang Eppel, Thomas M Stulnig, Peter Husslein, Christian Göbl
McArdle disease or glycogen storage disease (GSD) type V is a rare autosomal recessive inherited disorder in skeletal muscle metabolism leading to exercise intolerance, muscle cramps and in some cases to rhabdomyolysis and acute renal failure due to elevated serum myoglobin levels. Albeit the uterine smooth muscle is not affected, pregnancy and delivery can be physically strenuous and may require specific anesthesiologic care. However, data on pregnancy progress and outcome and on special implications linked to anesthesia in women with McArdle's disease is scarce, thus posing a challenge to pre- and peripartal management...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29533153/the-relationship-between-female-reproductive-functions-and-vitamin-d
#9
Sabriye Arslan, Yasemin Akdevelioğlu
Nonclassical target organs recently defined for vitamin D, a major regulator of calcium phosphorus homeostasis and bone health, include reproductive ones. This compilation study focuses on the potential effects of vitamin D on female reproductive functions. Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Most studies suggest that vitamin D may be directly or indirectly related to gonadal functions. Vitamin D's effects on reproductive functions may be indirectly related to diseases such as polycystic ovary syndrome (PCOS), uterine leiomyomas, and endometriosis...
March 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29492644/preoperative-18-f-fdg-pet-ct-tumour-heterogeneity-index-in-patients-with-uterine-leiomyosarcoma-a-multicentre-retrospective-study
#10
Jeong-Won Lee, Jeong-Yeol Park, Hyun Ju Lee, Jong Jin Lee, Seung Hwan Moon, Seo Young Kang, Gi Jeong Cheon, Hyun Hoon Chung
PURPOSE: We investigated the prognostic value of the tumour heterogeneity index determined on preoperative [18 F]FDG PET/CT in patients with uterine leiomyosarcoma (LMS). METHODS: We retrospectively reviewed patients with uterine LMS who underwent preoperative [18 F]FDG PET/CT scans at three tertiary referral hospitals. The PET/CT parameters maximum standardized uptake value of the primary tumour (SUVmax ), metabolic tumour volume (MTV) and total lesion glycolysis were assessed...
February 28, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29475127/brief-hypoxic-cycles-improve-uterine-contractile-function-after-prolonged-hypoxia-in-term-pregnant-but-not-in-nonpregnant-rats-in-vitro
#11
Mohammed Alotaibi
During labour, the uterus itself is vulnerable to hypoxia/ischemia that can occur with each strong contraction and this may ultimately cause dysfunctional labour in some women. Periods of Intermittent re-oxygenations are beneficial to tissues subjected to hypoxia to wash out metabolic by-products that have been accumulated during hypoxic stresses which may affect the tissue viability. We proposed that short intermittent hypoxic episodes may protect the uterus from subsequent sustained long hypoxia. To investigate this, two sets of experiments were performed on term-pregnant and nonpregnant rat uterine tissues...
February 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29471520/effect-of-exposure-to-second-hand-smoke-from-husbands-on-biochemical-hyperandrogenism-metabolic-syndrome-and-conception-rates-in-women-with-polycystic-ovary-syndrome-undergoing-ovulation-induction
#12
Jian Li, Q Wu, Xiao-Ke Wu, Zhong-Ming Zhou, Ping Fu, Xiu-Hua Chen, Ying Yan, Xin Wang, Zheng-Wang Yang, Wei-Li Li, Elisabet Stener-Victorin, Richard S Legro, Ernest Hung-Yu Ng, Heping Zhang, Ben Willem J Mol, Chi Chiu Wang
STUDY QUESTION: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction? SUMMARY ANSWER: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS. WHAT IS KNOWN ALREADY: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29466875/impacts-of-maternal-dietary-protein-intake-on-fetal-survival-growth-and-development
#13
Cassandra M Herring, Fuller W Bazer, Gregory A Johnson, Guoyao Wu
Maternal nutrition during gestation, especially dietary protein intake, is a key determinant in embryonic survival, growth, and development. Low maternal dietary protein intake can cause embryonic losses, intra-uterine growth restriction, and reduced postnatal growth due to a deficiency in specific amino acids that are important for cell metabolism and function. Of note, high maternal dietary protein intake can also result in intra-uterine growth restriction and embryonic death, due to amino acid excesses, as well as the toxicity of ammonia, homocysteine, and H2 S that are generated from amino acid catabolism...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29466770/neonatal-triphenyl-phosphate-and-its-metabolite-diphenyl-phosphate-exposure-induce-sex-and-dose-dependent-metabolic-disruptions-in-adult-mice
#14
Dezhen Wang, Wentao Zhu, Li Chen, Jin Yan, Miaomiao Teng, Zhiqiang Zhou
The widespread application of organophosphorous flame retardants (OPFRs) has led to considerable human exposure, with major concerns regarding their health risks. Herein, we investigate the effects of triphenyl phosphate (TPP), one of the most widely used OPFRs, and one of its main metabolite diphenyl phosphate (DPP) on the endocrine systems and metabolic profiles after neonatal exposure from postnatal days 1-10 at two dosages (2 and 200 μg per day). Both TPP and DPP had no negative effect on uterine weight, glucose tolerance, and estradiol...
February 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29457805/urinary-metabolomic-study-of-the-antagonistic-effect-of-p-ginseng-in-rats-with-estrogen-decline-using-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#15
He Lin, Zhongying Liu, Zifeng Pi, Lihui Men, Weijia Chen, Zhiqiang Liu
Estrogens are biologically active steroid hormones mainly released from the ovary by ovarian secretion of estrogen into the circulating blood to regulate or function at the distal target. Estrogens play an important role in the central nervous system, cardiovascular system and immune system, especially for post-menopausal women. Panax ginseng Mayer has been reported to relieve women's menopausal symptoms and affect estrogen activities. However, the mechanism of its estrogen regulation has not yet been clearly investigated...
February 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29434026/identification-of-early-indicators-of-altered-metabolism-in-normal-development-using-a-rodent-model-system
#16
Ashok Daniel Prabakaran, Jimsheena Valiyakath Karakkat, Ranjit Vijayan, Jisha Chalissery, Marwa F Ibrahim, Suneesh Kaimala, Ernest A Adeghate, Ahmed Hasan Al-Marzouqi, Suraiya Anjum Ansari, Mensah-Brown Epk, Bright Starling Emerald
Although the existence of a close relationship between the early maternal developmental environment, fetal size at birth and the risk of developing disease in adulthood has been suggested, most studies, however, employed experimentally induced intrauterine growth restriction as model to link this with later adult disease. Since embryonic size variation occurs under normal growth and differentataion as well, elucidating the molecular mechanisms underlying these changes and their relevance to later adult disease risk becomes important...
January 30, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29432237/hypoxic-ischemic-encephalopathy-and-other-neonatal-encephalopathies
#17
Hannah C Glass
PURPOSE OF REVIEW: Neonatal encephalopathy is the most common condition in neonates encountered by child neurologists. The etiology is most often global hypoxia-ischemia due to failure of cerebral perfusion to the fetus caused by uterine, placental, or umbilical cord compromise prior to or during delivery. Other etiologies of neonatal encephalopathy include ischemic stroke and intracranial hemorrhage, infection, developmental anomalies, and inborn errors of metabolism. RECENT FINDINGS: Therapeutic hypothermia is standard of care for the treatment of neonatal encephalopathy presumed to be caused by hypoxia-ischemia...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29422210/pathophysiology-of-placental-derived-fetal-growth-restriction
#18
REVIEW
Graham J Burton, Eric Jauniaux
Placental-related fetal growth restriction arises primarily due to deficient remodeling of the uterine spiral arteries supplying the placenta during early pregnancy. The resultant malperfusion induces cell stress within the placental tissues, leading to selective suppression of protein synthesis and reduced cell proliferation. These effects are compounded in more severe cases by increased infarction and fibrin deposition. Consequently, there is a reduction in villous volume and surface area for maternal-fetal exchange...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29406990/understanding-pluripotency-under-folic-acid-deficiency-using-embryonic-stem-cells-as-an-in-vitro-model
#19
Sowmya Kasulanati, Vijayalakshmi Venkatesan
Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or indirectly, with DNA and Histone methylation, One carbon metabolism has an important role to play as far as epigenetic regulation of stemness is concerned. Folic acid being a methyl donor, forms an important component of One Carbon metabolism, and thus its availability has a significant effect on the methylation reactions...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29402916/transcriptomic-changes-in-the-pre-implantation-uterus-highlight-histotrophic-nutrition-of-the-developing-marsupial-embryo
#20
Camilla M Whittington, Denis O'Meally, Melanie K Laird, Katherine Belov, Michael B Thompson, Bronwyn M McAllan
Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity...
February 5, 2018: Scientific Reports
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