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Uterine metabolism

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https://www.readbyqxmd.com/read/28730962/phosphonium-salt-displays-cytotoxic-effects-against-human-cancer-cell-lines
#1
Dhanyalayam Dhanya, Giuseppe Palma, AnnaRita Cappello, Annaluisa Mariconda, Maria Stefania Sinicropi, Francesca Giordano, Vitale Del Vecchio, Anna Ramunno, Claudio Arra, Pasquale Longo, Carmela Saturnino
Aims/ Objective: Phosphonium salts are compounds whose structural characteristics enable them to cross the plasma and mitochondrial membrane with ease. Cancer cells have higher plasma membrane potentials than normal cells, phosphonium salts selectively accumulate in the mitochondria of neoplastic cells and inhibit mitochondrial function. METHOD: In the presente work, we investigate the cytotoxic activity of lipophilic phosphonium salt (11-methoxy11-oxo-undecyl) triphenylphosphonium bromide (MUTP) as well as of two new phosphine oxide salts, 3,3'-(methylphosphoryl) dibenzenaminium chloride (SBAMPO) and 3,3' (phenylphosphoryl) dibenzenaminium chloride (SBAPPO) on the proliferation of breast cancer cell line (MCF-7) and human uterin cervix adenocarcinoma cells (HeLa)...
July 19, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28722155/metabolite-availability-as-a-window-to-view-the-early-embryo-microenvironment-in-vivo
#2
REVIEW
Kailun Hu, Yang Yu
A preimplantation embryo exists independent of blood supply, and relies on energy sources from its in vivo environment (e.g. oviduct and uterine fluid) to sustain its development. The embryos can survive in this aqueous environment because it contains amino acids, proteins, lactate, pyruvate, oxygen, glucose, antioxidants, ions, growth factors, hormones, and phospholipids - albeit the concentration of each component varies by species, stage of the estrous cycle, and anatomical location. The dynamic nature of this environment sustains the early development from the one-cell zygote to blastocyst, and is reciprocally influenced by the embryo at each embryonic stage...
July 19, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28708519/relationships-between-uterine-health-and-metabolism-in-dairy-cows-with-different-dry-period-lengths
#3
J Chen, N M Soede, G J Remmelink, R M Bruckmaier, B Kemp, A T M van Knegsel
The first objective of this study was to evaluate effects of dry period (DP) length and dietary energy source on ovarian activity, uterine health status, pregnancy rate, and days open in dairy cows in the second subsequent lactation after implementation of DP length and dietary treatments. The second objective was to determine relationships of uterine health status with ovarian activity, milk yield, energy balance (EB), and metabolic status in dairy cows. Holstein-Friesian dairy cows (n = 167) were assigned randomly to 1 of 3 DP lengths (0-, 30-, or 60-d) and 1 of 2 early lactation diets (glucogenic or lipogenic diet) for 2 subsequent lactations...
June 13, 2017: Theriogenology
https://www.readbyqxmd.com/read/28681119/antiosteoporotic-activity-of-a-syringic-acid-diet-in-ovariectomized-mice
#4
Teruyoshi Tanaka, Nobuhisa Kawaguchi, Nobuhiro Zaima, Tatsuya Moriyama, Yasuhisa Fukuta, Norifumi Shirasaka
In recent years, the number of patients with osteoporosis has risen with the increase in average longevity. Therefore, the chemoprevention of osteoporosis using food materials or food components has become an increasingly important target. Syringic acid (SA) is a phenolic compound present in the fruit of the açaí palm Euterpe oleracea and the mycelium of the shiitake mushroom Lentinula edodes. This compound has no affinity for estrogen receptors and is potentially useful for disease prevention. However, little is known about the effects of a SA diet on bone metabolism, particularly bone resorption in vivo...
July 5, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28645863/toxicology-of-octamethylcyclotetrasiloxane-d4
#5
Allison Franzen, Tracy Greene, Cynthia Van Landingham, Robinan Gentry
Octamethylcyclotetrasiloxane (D4) is a volatile cyclic siloxane used primarily as a monomer or intermediate in the production of some silicon-based polymers widely used in industrial and consumer applications and may be present as a residual impurity in a variety of consumer products. A robust toxicological data set exists for D4. Treatment-related results from a chronic inhalation study conducted in rats are limited to mild effects on the respiratory tract, increases in liver weight, increases in the incidence of uterine endometrial epithelial hyperplasia, and a dose-related trend in the incidence of endometrial adenomas...
June 20, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28631256/vulnerability-to-a-metabolic-challenge-following-perinatal-asphyxia-evaluated-by-organotypic-cultures-neonatal-nicotinamide-treatment
#6
R Perez-Lobos, C Lespay-Rebolledo, A Tapia-Bustos, E Palacios, V Vío, D Bustamante, P Morales, M Herrera-Marschitz
The hypothesis of enhanced vulnerability following perinatal asphyxia was investigated with a protocol combining in vivo and in vitro experiments. Asphyxia-exposed (AS) (by 21 min water immersion of foetuses containing uterine horns) and caesarean-delivered control (CS) rat neonates were used at P2-3 for preparing triple organotypic cultures (substantia nigra, neostriatum and neocortex). At DIV 18, cultures were exposed to different concentrations of H2O2 (0.25-45 mM), added to the culture medium for 18 h...
June 19, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28630707/evidence-of-endometrial-amino-acid-metabolism-and-transport-modulation-by-peri-ovulatory-endocrine-profiles-driving-uterine-receptivity
#7
Moana Rodrigues França, Maressa Izabel Santos da Silva, Guilherme Pugliesi, Veerle Van Hoeck, Mario Binelli
BACKGROUND: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle (POF) and the resulting elevated concentrations of progesterone (P4) during diestrus positively affect pregnancy rates. Amino acids (AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28625536/reconstructing-lineage-hierarchies-of-mouse-uterus-epithelial-development-using-single-cell-analysis
#8
Bingbing Wu, Chengrui An, Yu Li, Zi Yin, Lin Gong, Zhenli Li, Yixiao Liu, Boon Chin Heng, Dandan Zhang, Hongwei Ouyang, Xiaohui Zou
The endometrial layer comprises luminal and glandular epithelia that both develop from the same simple layer of fetal uterine epithelium. Mechanisms of uterine epithelial progenitor self-renewal and differentiation are unclear. This study aims to systematically analyze the molecular and cellular mechanisms of uterine epithelial development by single-cell analysis. An integrated set of single-cell transcriptomic data of uterine epithelial progenitors and their differentiated progenies is provided. Additionally the unique molecular signatures of these cells, characterized by sequential upregulation of specific epigenetic and metabolic activities, and activation of unique signaling pathways and transcription factors, were also investigated...
July 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28623968/oxygen-and-tissue-culture-affect-placental-gene-expression
#9
O Brew, M H F Sullivan
INTRODUCTION: Placental explant culture is an important model for studying placental development and functions. We investigated the differences in placental gene expression in response to tissue culture, atmospheric and physiologic oxygen concentrations. METHODS: Placental explants were collected from normal term (38-39 weeks of gestation) placentae with no previous uterine contractile activity. Placental transcriptomic expressions were evaluated with GeneChip(®) Human Genome U133 Plus 2...
July 2017: Placenta
https://www.readbyqxmd.com/read/28587493/a-randomized-controlled-trail-of-a-new-treatment-for-labor-dystocia
#10
Eva Wiberg-Itzel, Susan Wray, Helena Åkerud
OBJECTIVE: Labor dystocia is an intransigent, high-profile issue in obstetric care. Amniotic fluid lactate (AFL) reflects the uterine metabolic status. High levels associate with subsequent need for operative intervention due to dystocia. In sports medicine it is known that lactic acid can affect muscular performance and can be decreased by bicarbonate given orally before physical activity. MATERIAL AND METHODS: Two hundred dystocic deliveries were included. At the confirmation of dystocia, the AFL- level was analyzed...
June 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28553146/recurrent-pregnancy-loss-current-perspectives
#11
REVIEW
Hady El Hachem, Vincent Crepaux, Pascale May-Panloup, Philippe Descamps, Guillaume Legendre, Pierre-Emmanuel Bouet
Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28541634/prognostic-value-of-metabolic-parameters-determined-by-preoperative-%C3%A2-%C3%A2-f-fdg-pet-ct-in-patients-with-uterine-carcinosarcoma
#12
Hyun Ju Lee, Jong Jin Lee, Jeong Yeol Park, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: To evaluate the prognostic value of metabolic parameters measured by preoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) in patients with uterine carcinosarcoma (UCS). METHODS: Data of 55 eligible patients with UCS who underwent preoperative ¹⁸F-FDG PET/CT and surgical staging were analyzed retrospectively. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV₂.₅), and total lesion glycolysis (TLG₂...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28534183/prognostic-importance-of-lymph-node-to-primary-tumor-standardized-uptake-value-ratio-in-invasive-squamous-cell-carcinoma-of-uterine-cervix
#13
Hyun Hoon Chung, Gi Jeong Cheon, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song
PURPOSE: Using integrated PET/CT, we evaluated the prognostic value of [(18)F]FDG uptake ratio between pelvic lymph node (LN) and primary tumor in invasive squamous cell carcinoma (SCCA) of the uterine cervix. METHODS: We retrospectively reviewed patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB to IIA cervical SCCA who underwent preoperative [(18)F]FDG PET/CT scans. PET/CT parameters such as maximum standardized uptake value (SUV) of the primary cervical cancer (SUVcervix) and LN (SUVLN), and the LN-to-cervical cancer SUV ratio (SUVLN/SUVcervix) were assessed...
May 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#14
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
July 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#15
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
May 18, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28523389/effects-of-calving-season-on-the-voluntary-waiting-period-and-reproductive-performance-of-holstein-cows-in-the-tropical-savannah
#16
Thiago Vilar Silva, Benner Geraldo Alves, Kele Amaral Alves, Regiani Nascimento Gagno Porto, Maria Lucia Gambarini
The effects of calving season [rainy (RS) and dry (DS)] on the voluntary waiting period (VWP) of 58 Holstein cows raised in the tropical savannah were investigated using data of temperature humidity index (THI), total antioxidant status (TAS), respiratory rate (RR), rectal temperature (RT), glucose, total cholesterol (TC), triglycerides (TG), velocity of uterine regression, and subsequent reproductive performance. Blood samples and clinical data were taken once every week, from calving until the sixth postpartum week...
August 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28508679/comparison-of-fdg-pet-metabolic-tumour-volume-versus-adc-histogram-prognostic-value-of-tumour-treatment-response-and-survival-in-patients-with-locally-advanced-uterine-cervical-cancer
#17
COMPARATIVE STUDY
Yoshiko Ueno, Robert Lisbona, Tsutomu Tamada, Amer Alaref, Kazuro Sugimura, Caroline Reinhold
OBJECTIVE: To evaluate the prognostic utility of volume-based parameters of fluorine-18 fludeoxyglucose positron emission tomography ((18)F-FDG PET) and apparent diffusion coefficient (ADC) histogram analysis for tumour response to therapy and event-free survival (EFS) in patients with uterine cervical cancer receiving chemoradiotherapy. METHODS: The study included 21 patients diagnosed with locally advanced uterine cervical cancer who underwent pre-treatment MRI and (18)F-FDG PET and were treated with concurrent chemoradiotherapy...
July 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28483502/oxidative-stress-a-key-regulator-of-leiomyoma-cell-survival
#18
Nicole M Fletcher, Mohammed S Abusamaan, Ira Memaj, Mohammed G Saed, Ayman Al-Hendy, Michael P Diamond, Ghassan M Saed
OBJECTIVE: To determine the effects of attenuating oxidative stress with the use of dichloroacetate (DCA) on the expression of key redox enzymes myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) as well as on apoptosis. DESIGN: Prospective experimental study. SETTING: University medical center. PATIENT(S): Cells established from myometrium and uterine fibroid from the same patients. INTERVENTION(S): Cells were exposed to normal (20% O2) or hypoxic (2% O2) conditions for 24 hours with or without DCA (20 μg/mL), a metabolic modulator that shifts anaerobic to aerobic metabolism...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28472298/adiponectin-stimulates-lipid-metabolism-via-ampk-in-rabbit-blastocysts
#19
Maria Schindler, Mareike Pendzialek, Katarzyna Joanna Grybel, Tom Seeling, Jacqueline Gürke, Bernd Fischer, Anne Navarrete Santos
STUDY QUESTION: How does a maternal diabetic hyperadiponectineamia affect signal transduction and lipid metabolism in rabbit preimplantation blastocysts? SUMMARY ANSWER: In a diabetic pregnancy increased levels of adiponectin led to a switch in embryonic metabolism towards a fatty acid-dependent energy metabolism, mainly affecting genes that are responsible for fatty acid uptake and turnover. WHAT IS KNOWN ALREADY: Although studies in cell culture experiments have shown that adiponectin is able to regulate lipid metabolism via 5'-AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα), data on the effects of adiponectin on embryonic lipid metabolism are not available...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28469842/peripheral-leukocyte-and-endometrium-molecular-biomarkers-of-inflammation-and-oxidative-stress-are-altered-in-peripartal-dairy-cows-supplemented-with-zn-mn-and-cu-from-amino-acid-complexes-and-co-from-co-glucoheptonate
#20
Fernanda Batistel, Johan S Osorio, Muhammad Rizwan Tariq, Cong Li, Jessica Caputo, Michael T Socha, Juan J Loor
BACKGROUND: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early lactation. RESULTS: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals (INO) or complexed trace minerals (AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition...
2017: Journal of Animal Science and Biotechnology
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