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Uterine metabolism

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https://www.readbyqxmd.com/read/29908848/the-obesogen-tributyltin-induces-abnormal-ovarian-adipogenesis-in-adult-female-rats
#1
Julia F P de Araújo, Priscila L Podratz, Gabriela C Sena, Eduardo Merlo, Leandro C Freitas-Lima, Júlia Gringorini Mori Ayub, Amanda Fidalgo Zogaib Pereira, Ana Paula Santos-Silva, Leandro Miranda-Alves, Ian V Silva, Jones B Graceli
Tributyltin chloride (TBT) is an obesogen associated with various metabolic and reproductive dysfunctions after in utero exposure. However, few studies have evaluated TBT's obesogenic effect on adult ovaries. In this study, we assessed whether TBT's obesogenic effects resulted in adult ovarian adipogenesis and other reproductive abnormalities. TBT was administered to adult female Wistar rats, and their reproductive tract morphophysiology was assessed. We further assessed the ovarian mRNA/protein expression of genes that regulate adipogenesis...
June 14, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29908751/induction-of-uterine-hyperplasia-after-cafeteria-diet-exposure
#2
María Paula Gastiazoro, Marlise Guerrero Schimpf, Milena Durando, Gisela Paola Lazzarino, María Florencia Andreoli, Oliver Zierau, Enrique Hugo Luque, Jorge Guillermo Ramos, Jorgelina Varayoud
Our aim was to evaluate whether chronic administration of CAF affects the uterus and induces the morphological and molecular changes associated with endometrial hyperplasia. Female Wistar rats exposed to CAF from weaning for 20 weeks displayed increased energy intake, body weight and fat depots, but did not develop metabolic syndrome. The adult uteri showed an increase in glandular volume fraction and stromal area. The epithelial proliferation rate and protein expression of oestrogen receptor alpha (ERα) were also increased...
June 14, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29906034/schmidt%C3%A2-s-syndrome-a-difficult-diagnosis-in-the-latin-american-context
#3
Claudia Barreda-Velit, Rodrigo Salcedo-Pereda, Jesús Ticona
Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. The diagnosis consists in the concomitant presentation of Addison disease, autoimmune thyroid disease and other autoimmune endocrinological conditions. The aim of this paper is to describe a case of Schmidt’s syndrome in the peruvian context and to analyze the difficulties in the diagnosis. Clinical case: We present the case of a 43-year-old woman that presents to the emergency room with headache, nausea, vomits and a “syncope episode”...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29904382/retinoic-acid-receptor-related-orphan-receptors-critical-roles-in-tumorigenesis
#4
REVIEW
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing to cancer-related processes have been growing, and they provide evidence that RORs are likely to be considered as potential therapeutic targets in many cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29887695/inadequately-staged-endometrial-cancer-a-clinical-dilemma
#5
Vinotha Thomas, Anitha Thomas, Ajit Sebastian, Rachel Chandy, Abraham Peedicayil
Incidental diagnosis of carcinoma endometrium following hysterectomy requires clinical expertise from a gynecologic oncologist, with regard to subsequent management. We report our experience with completion staging in endometrial cancer, to determine the benefits and risks of completion staging in women with posthysterectomy diagnosis of endometrial cancer. DESIGN: A retrospective case series of 20 women with postoperative diagnosis of endometrial cancer, who had undergone completion staging...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29844831/identification-of-key-genes-and-pathways-in-uterine-leiomyosarcoma-through-bioinformatics-analysis
#6
Yuqin Zang, Lina Gu, Yanfang Zhang, Yingmei Wang, Fengxia Xue
Uterine leiomyosarcoma (uLMS) is a rare but malignant gynaecological tumour with a poor survival outcome. The present study was aimed at identifying the key genes and pathways in the development of uLMS through bioinformatics analysis. To minimize the frequency of false-positive results of the bioinformatics analysis, 3 microarrays including GSE764, GSE64763 and GSE68312 were downloaded from Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were screened out using the online tool GEO2R. Then, Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29803894/impact-of-selective-serotonin-reuptake-inhibitors-ssris-during-pregnancy-and-lactation-a-focus-on-short-and-long-term-vascular-effects
#7
REVIEW
S Zullino, T Simoncini
SSRIs are the first choice for the treatment of mood disorders during pregnancy and lactation. Despite the known side effects, the benefits/risks balance suggests their use. Hypertensive disorders of pregnancy (HDP) and Intrauterine growth restriction (IUGR) are the main vascular effects of these drugs, with mechanisms that involves endothelial dysfunction in feto-placental system. These data are supported by animal models, even if preliminary findings are not yet adequately supported by molecular and clinical data...
May 24, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29775456/maternal-obesogenic-diet-induces-endometrial-hyperplasia-an-early-hallmark-of-endometrial-cancer-in-a-diethylstilbestrol-mouse-model
#8
Theresa O Owuor, Michaela Reid, Lauren Reschke, Ian Hagemann, Suellen Greco, Zeel Modi, Kelle H Moley
Thirty-eight percent of US adult women are obese, meaning that more children are now born of overweight and obese mothers, leading to an increase in predisposition to several adult onset diseases. To explore this phenomenon, we developed a maternal obesity animal model by feeding mice a diet composed of high fat/ high sugar (HF/HS) and assessed both maternal diet and offspring diet on the development of endometrial cancer (ECa). We show that maternal diet by itself did not lead to ECa initiation in wildtype offspring of the C57Bl/6J mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29774596/epidemiological-analysis-of-maternal-lipid-levels-during-the-second-trimester-in-pregnancy-and-the-risk-of-adverse-pregnancy-outcome-adjusted-by-pregnancy-bmi
#9
Chao-Yan Yue, Chun-Mei Ying
BACKGROUND: Pregnancy is accompanied by profound changes in lipid metabolism. We aimed to assess whether effects of second trimester body mass index and maternal lipid concentrations are associated with an increased risk of adverse pregnancy outcomes. METHODS: We investigated the serum levels of maternal lipids during the second trimester in pregnancy, and analyzed associations between the lipid levels and the risk of adverse pregnancy outcome. Seven hundred and seventy-four pregnant women were enrolled in this study between February 2016 and June 2016...
May 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29772707/pimt-ncoa6ip-deletion-in-the-mouse-heart-causes-delayed-cardiomyopathy-attributable-to-perturbation-in-energy-metabolism
#10
Yuzhi Jia, Ning Liu, Navin Viswakarma, Ruya Sun, Mathew J Schipma, Meng Shang, Edward B Thorp, Yashpal S Kanwar, Bayar Thimmapaya, Janardan K Reddy
PIMT/NCOA6IP, a transcriptional coactivator PRIP/NCOA6 binding protein, enhances nuclear receptor transcriptional activity. Germline disruption of PIMT results in early embryonic lethality due to impairment of development around blastocyst and uterine implantation stages. We now generated mice with Cre-mediated cardiac-specific deletion of PIMT (csPIMT-/- ) in adult mice. These mice manifest enlargement of heart, with nearly 100% mortality by 7.5 months of age due to dilated cardiomyopathy. Significant reductions in the expression of genes (i) pertaining to mitochondrial respiratory chain complexes I to IV; (ii) calcium cycling cardiac muscle contraction ( Atp2a1 , Atp2a2 , Ryr2 ); and (iii) nuclear receptor PPAR- regulated genes involved in glucose and fatty acid energy metabolism were found in csPIMT-/- mouse heart...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#11
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29745858/kf-finder-identification-of-key-factors-from-host-microbial-networks-in-cervical-cancer
#12
Jialu Hu, Yiqun Gao, Yan Zheng, Xuequn Shang
BACKGROUND: The human body is colonized by a vast number of microbes. Microbiota can benefit many normal life processes, but can also cause many diseases by interfering the regular metabolism and immune system. Recent studies have demonstrated that the microbial community is closely associated with various types of cell carcinoma. The search for key factors, which also refer to cancer causing agents, can provide an important clue in understanding the regulatory mechanism of microbiota in uterine cervix cancer...
April 24, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29742599/the-detection-of-uterine-leiomyoma-fibroid-calcifications-on-18f-naf-pet-ct
#13
Abdullah Al-Zaghal, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
Uterine leiomyomas (fibroids) are the most common type of uterine neoplasms in premenopausal women. Leiomyomas are estrogen dependent and tend to atrophy and shrink in size after menopause. Dystrophic calcification, cystic changes, and necrosis are among the changes that indicate uterine fibroid involution. We are presenting a calcified uterine leiomyoma in a 61-year-old woman as incidentally detected on F-NaF PET/CT scanning. Many previous publications have reported the accumulation of F-NaF in soft tissue calcifications; these findings further set new directions in the evaluation of the metabolic activity of macrocalcification and microcalcification using molecular imaging probes...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29741587/obesity-in-mares-promotes-uterine-inflammation-and-alters-embryo-lipid-fingerprints-and-homeostasis
#14
Dawn R Sessions-Bresnahan, Adam L Heuberger, Elaine M Carnevale
Maternal body composition can be an important determinant for development of obesity and metabolic syndrome in adult offspring. Obesity-related outcomes in offspring may include epigenetic alterations; however, mechanisms of fetal programming remain to be fully elucidated. This study was conducted to determine the impact of maternal obesity in the absence of a high fat diet on equine endometrium and preimplantation embryos. Embryos were collected from normal and obese mares at 8 and 16 d and a uterine biopsy at 16 d (0 d = ovulation)...
May 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29722258/diet-impacts-preimplantation-histotroph-proteome-in-beef-cattle
#15
KaLynn Harlow, Emily Taylor, Theresa Casey, Victoria Hedrick, Tiago Sobreira, Uma K Aryal, Ronald P Lemenager, Bethany Funnell, Kara Stewart
In ruminants, the period from fertilization to implantation is relatively prolonged, and survival of embryos depends on uterine secretions, or histotroph. Our objective was to determine if prebreeding diet affected histotroph proteome in beef cattle. Cows were assigned to 1 of 4 diets: control (CON), high protein (PROT), high fat (OIL), or high protein and fat (PROT+OIL). After 185d on diets, an intravaginal progesterone implant (CIDR) was inserted for 7 days. At 9 days post CIDR removal, animals with a corpus luteum were selected (n = 16; 4/treatment)...
May 3, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29698887/hypoxia-dependent-accumulation-of-hypoxia-inducible-factor-1-alpha-induces-transient-cell-cycle-arrest-in-porcine-trophectoderm-cells
#16
Wooyoung Jeong, Seoungo Jung, Fuller W Bazer, Jinyoung Kim
In the uterine environment, the pre-implantation embryo adapts to low oxygen concentrations through intracellular responses including modification of gene expression, progression via the cell cycle and metabolism. In this study, we determined mechanisms underlying the adaptation of pig embryos to oxygen deficiency in the maternal-conceptus microenvironment in in vitro experiments using our established porcine trophectoderm (pTr) cells in culture. The transition from G1 to S phase in pTr cells was reduced in response to 2% oxygen during a short period (<24 h), and the hypoxia-induced G1 arrest was reversible during prolonged hypoxia exposure...
April 14, 2018: Theriogenology
https://www.readbyqxmd.com/read/29688258/isoprenoids-increase-bovine-endometrial-stromal-cell-tolerance-to-the-cholesterol-dependent-cytolysin-from-trueperella-pyogenes
#17
Sholeem Griffin, Gareth D Healey, I Martin Sheldon
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition. Postpartum uterine disease and endometrial pathology in cattle is most associated with the pathogen Trueperella pyogenes. Trueperella pyogenes secretes a cholesterol-dependent cytolysin, pyolysin, which causes cytolysis by forming pores in the plasma membrane of endometrial stromal cells. The aim of the present study was to identify cell-intrinsic pathways that increase bovine endometrial stromal cell tolerance to pyolysin...
April 24, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29684197/impact-of-sow-energy-status-during-farrowing-on-farrowing-kinetics-frequency-of-stillborn-piglets-and-farrowing-assistance
#18
Takele Feyera, Trine Friis Pedersen, Uffe Krogh, Leslie Foldager, Peter Kappel Theil
Farrowing duration is rather long in sows most likely due to selection for large litters, and we hypothesized that prolonged farrowings would compromise sow energy status during farrowing and in turn the farrowing process. Two studies were performed as follows: 1) to evaluate whether sow energy status during farrowing compromise the farrowing kinetics (FK, i.e., farrowing duration and birth intervals) and 2) to study the underlying mechanisms potentially affecting stillbirth rate and farrowing assistance. In study-1, parameters affecting FK were characterized based on data from a total of 166 farrowings from 7 feeding trials focused on sow colostrum production...
June 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29661800/chorionic-somatomammotropin-impacts-early-fetal-growth-and-placental-gene-expression
#19
K J Jeckel, A C Boyarko, G J Bouma, Q A Winger, R V Anthony
Several developmental windows, including placentation, must be negotiated to establish and maintain pregnancy. Impaired placental function can lead to preeclampsia and/or intrauterine growth restriction (IUGR), resulting in increased infant mortality and morbidity. It has been hypothesized that chorionic somatomammotropin (CSH) plays a significant role in fetal development, potentially by modifying maternal and fetal metabolism. Recently, using lentiviral-mediated in vivo RNA interference in sheep, we demonstrated significant reductions in near-term (135 days of gestation; dGA) fetal and placental size, and altered fetal liver gene expression, resulting from CSH deficiency...
June 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29659523/antibacterial-efficacy-of-silver-nanoparticles-on-endometritis-caused-by-prevotella-melaninogenica-and-arcanobacterum-pyogenes-in-dairy-cattle
#20
Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim
Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals...
April 16, 2018: International Journal of Molecular Sciences
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