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https://www.readbyqxmd.com/read/29906700/patient-characteristics-and-treatment-patterns-in-patients-with-newly-diagnosed-epilepsy-a-us-database-analysis
#1
Edward Faught, Sandra Helmers, David Thurman, Hyunmi Kim, Linda Kalilani
OBJECTIVE: The objective of this study was to determine patient characteristics and antiepileptic drug (AED) treatment patterns in patients with newly diagnosed epilepsy in a United States (US) population followed for ≥180 days. METHODS: In this retrospective cohort study, Commercial, Supplemental Medicare, and Medicaid insurance claims from US-based Truven Health MarketScan® claims database were analyzed for incident epilepsy cases (index date: January 2010-June 2013; prior baseline of 2 years [1 year for ages 1 to <2 years; none for those <1 year])...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906680/an-updated-assessment-of-morbidity-and-mortality-following-skull-base-surgical-approaches
#2
Brittany N Burton, Jenny Q Hu, Aria Jafari, Richard D Urman, Ian F Dunn, W Linda Bi, Adam S DeConde, Rodney A Gabriel
OBJECTIVES: Updated multi-institutional database studies assessing perioperative risk factors on 30-day morbidity and mortality after skull base surgeries are limited. We aim to identify perioperative risk factors and report the incidence of 30-day morbidity and mortality in adult patients after skull base surgery. PATIENTS AND METHODS: We queried the 2007-2016 American College of Surgeons National Surgical Quality Improvement program database to identify patients who underwent anterior, middle, or posterior skull base surgery...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29906644/retroperitoneal-versus-open-intraperitoneal-necrosectomy-in-step-up-therapy-for-infected-necrotizing-pancreatitis-a-meta-analysis
#3
REVIEW
Yun-Bing Wang, Xiao-Li Yang, Long Chen, Zheng-Ju Chen, Chun-Mu Miao, Jin Xia
BACKGROUND: Step-up therapy is the recommended therapy for infected necrotizing pancreatitis (INP). However, the most appropriate secondary therapy for use after initial drainage has not been fully determined. This meta-analysis was designed to evaluate the efficacy and safety of retroperitoneal versus open intraperitoneal necrosectomy as part of a step-up strategy for INP. MATERIALS AND METHODS: Eight online databases were searched for randomized controlled trials (RCTs) and cohorts comparing retroperitoneal and open intraperitoneal step-up approaches for treating INP...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29906643/the-efficacy-and-safety-comparison-of-docetaxel-cabazitaxel-estramustine-and-mitoxantrone-for-castration-resistant-prostate-cancer-a-network-meta-analysis
#4
Pan Song, Chuiguo Huang, Yan Wang
AIMS: The aim of this study was to compare the efficacy and safety of docetaxel, cabazitaxel, docetaxel + estramustine, mitoxantrone in the management of castration-resistant prostate cancer (CRPC). METHODS: Electronic databases including PubMed, Cochrance Library and Embase were searched for studies published from when the databases were established to January 1 s t, 2018. Randomized controlled trials (RCTs) that compared docetaxel + prednisone (DP), cabazitaxel + prednisone (CP), docetaxel + estramustine + prednisone (DEP), and mitoxantrone + cabazitaxel prednisone (MP) for CRPC treatment were identified...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29906615/studying-a-rare-disease-using-multi-institutional-research-collaborations-vs-big-data-where-lies-the-truth
#5
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Multi-institutional collaborations provide granularity lacking in epidemiologic datasets to enable in-depth study of rare diseases. For pts with superficial, high-grade soft tissue sarcomas (STS) of the trunk/extremity, the value of radiation therapy (RT) is not clear. We aimed to utilize the 7-institution US-Sarcoma-Collaborative (USSC) and the National Cancer Database (NCDB) to investigate this issue. STUDY DESIGN: All adult pts with superficial truncal/extremity high-grade STS who underwent primary curative-intent resection from 2000-2016 at USSC institutions or were included in the NCDB from 2004-2013 were analyzed...
June 12, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29906583/prevalence-incidence-co-morbidity-and-mortality-rates-of-ossification-of-posterior-longitudinal-ligament-opll-in-the-cervical-spine-a-nested-case-control-cohort-study
#6
Bong Ju Moon, Sun Kyu Choi, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Yoon Ha
OBJECT: To evaluate the prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL), using data from a 12-year national cohort of 1,025,340 Korean people. METHODS: A nested case-control cohort study was performed using the insurance claims database, during 2002 to 2013, provided by the National Health Insurance Service. We examined the prevalence and incidence of cervical OPLL. Age/sex-matched controls were randomly extracted, with 10 times the number of OPLL cases...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906531/association-between-matrix-metalloproteinase-family-gene-polymorphisms-and-risk-of-ischemic-stroke-a-systematic-review-and-meta-analysis-of-29-studies
#7
REVIEW
Shubham Misra, Pumanshi Talwar, Amit Kumar, Pradeep Kumar, Ram Sagar, Deepti Vibha, Awadh K Pandit, Arti Gulati, Suman Kushwaha, Kameshwar Prasad
BACKGROUND: Ischemic stroke (IS) is a complex and devastating vascular disease that has become one of the leading causes of disability and mortality worldwide. Several studies have shown the association between matrix metalloproteinase (MMP) family gene polymorphisms and IS. However, the results have been indecisive. OBJECTIVE: To investigate the association between Matrix Metalloproteinase gene polymorphisms and risk of IS. METHODS: A literature search for eligible candidate gene studies published before, 28 June 2017, was conducted in the PubMed, EMBASE, Cochrane and Google Scholar databases...
June 12, 2018: Gene
https://www.readbyqxmd.com/read/29906523/ventricular-fibromas-in-children-arrhythmia-risk-and-outcomes-a-multicentre-study
#8
John P Jones, Tristan Ramcharan, Milind Chaudhari, Vinay Bhole, Karen Mcleod, Shankar Sadagopan, Orhan Uzun, Andrew Parry, Jan Till, Colin J McMahon, Alan G Stuart, Mark A Walsh
BACKGROUND: Although ventricular fibromas are a rare, they are the second most common type of cardiac tumor in children. While histologically benign, they have a propensity to cause malignant arrhythmias, with cardiac arrest often being the first presentation.; OBJECTIVE: To evaluate the arrhythmia risk, and management strategies for pediatric ventricular fibromas. METHODS: Fifteen centers in the British Paediatric Arrhythmia Group network were contacted to partake in the study to contribute cases...
June 12, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29906469/the-potential-risk-of-toxoplasmosis-for-traffic-accidents-a-systematic-review-and-meta-analysis
#9
Shaban Gohardehi, Mehdi Sharif, Shahabeddin Sarvi, Mahmood Moosazadeh, Reza Alizadeh-Navaei, Seyed Abdollah Hosseini, Afsaneh Amouei, Abdolsattar Pagheh, Mitra Sadeghi, Ahmad Daryani
Toxoplasmosis is a prevalent infectious disease. Although most people infected by Toxoplasma gondii are asymptomatic, evidence has suggested that this disease might affect some aspects of a host's behavior and associate with schizophrenia, suicide attempt, changes in various aspects of personality, and poor neurocognitive performance. These associations may play roles in increasing the risk of a number of incidents, such as traffic accidents, among infected people. In this regard, this study aimed to provide summary estimates for the available data on the potential risk of toxoplasmosis for traffic accidents...
June 12, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29906426/importance-of-early-insertion-of-inferior-vena-cava-filters-in-unstable-patients-with-acute-pulmonary-embolism
#10
Paul D Stein, Fadi Matta, Frank R Lawrence, Mary J Hughes
BACKGROUND: Immortal time bias is a possible confounding factor in cohort studies. In this investigation, we assessed mortality with inferior vena cava (IVC) filters in unstable patients with pulmonary embolism using a design that eliminated immortal time bias. METHODS: Data are from Premier Healthcare Database, 2010-2014. International Classification of Disease-9th Clinical Modification codes were used. Unstable patients with pulmonary embolism and an admitting diagnosis of pulmonary embolism as well as a primary diagnosis of pulmonary embolism were included...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29906419/the-utility-of-long-non-coding-rna-zeb1-as1-as-a-prognostic-biomarker-in-human-solid-tumors-a-meta-analysis
#11
REVIEW
Xue-Liang Zuo, Juan Cai, Zhi-Qiang Chen, Yao Zhang, Lin-Hu Liang, Jun-Feng Wang, Jin-Guo Wang, Jian Wu, Jia-Ding Mao
PURPOSE: This meta-analysis aims to assess the prognostic value of long non-coding RNA ZEB1-AS1 in human solid tumors. METHODS: We searched the available databases up to January 2018. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of ZEB1-AS1 on patient survival. RESULTS: Eight eligible studies with a total of 586 patients were enrolled. A significant association was observed between ZEB1-AS1 overexpression and poor overall survival (OS; HR = 2...
June 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29906414/guide-rna-selection-for-crispr-cas9-transfections-in-plasmodium-falciparum
#12
Jose M Ribeiro, Meera Garriga, Nicole Potchen, Anna K Crater, Ankit Gupta, Daisuke Ito, Sanjay A Desai
CRISPR-Cas9 mediated genome editing is addressing key limitations in the transfection of malaria parasites. While this method has already simplified the needed molecular cloning and reduced the time required to generate mutants in the human pathogen Plasmodium falciparum, optimal selection of required guide RNAs and guidelines for successful transfections have not been well characterized, leading workers to use time-consuming trial and error approaches. We used a genome-wide computational approach to create a comprehensive and publicly accessible database of possible guide RNA sequences in the P...
June 12, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29906320/linking-interprofessional-work-to-outcomes-for-employees-a-meta-analysis
#13
Sabine Kaiser, Joshua Patras, Monica Martinussen
The aim of this meta-analysis of studies of workers in the health and social care sector was to examine the relationship between interprofessional work and employee outcomes of job stress, autonomy, burnout, engagement, job satisfaction, turnover intention, and perceived service quality, and to examine the influence of different moderators on those relationships. A systematic literature search of the PsycInfo, Embase, Medline, and the Cumulative Index to Nursing and Allied Health Literature databases was conducted to identify relevant articles...
June 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#14
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29906265/transcatheter-mitral-valve-in-valve-and-valve-in-ring-replacement-in-high-risk-surgical-patients-feasibility-safety-and-longitudinal-outcomes-in-a-single-center-experience
#15
Ashleigh Long, Paul Mahoney
BACKGROUND: Transcatheter mitral valve-in-valve (TMVIV) or valve-in-ring (TMVIR) replacement has shown early promise in patients deemed poor surgical candidates as a less invasive alternative to conventional reoperative mitral valve (MV) replacement. OBJECTIVE: This retrospective, single-center study reviewed the procedural outcomes of all TMVIV and TMVIR procedures between 2013-2018 at a large tertiary referral center serving the southeastern United States. An analysis of patient safety measures was also performed, with a retrospective assessment of relative procedural safety that included preoperative risk stratification and postoperative mortality predictors, operative time, average blood loss, length of hospital stay, and readmission rates...
June 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29906258/genometrakr-proficiency-testing-for-foodborne-pathogen-surveillance-an-exercise-from-2015
#16
Ruth E Timme, Hugh Rand, Maria Sanchez Leon, Maria Hoffmann, Errol Strain, Marc Allard, Dwayne Roberson, Joseph D Baugher
Pathogen monitoring is becoming more precise as sequencing technologies become more affordable and accessible worldwide. This transition is especially apparent in the field of food safety, which has demonstrated how whole-genome sequencing (WGS) can be used on a global scale to protect public health. GenomeTrakr coordinates the WGS performed by public-health agencies and other partners by providing a public database with real-time cluster analysis for foodborne pathogen surveillance. Because WGS is being used to support enforcement decisions, it is essential to have confidence in the quality of the data being used and the downstream data analyses that guide these decisions...
June 15, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29906006/topical-application-of-5-fluorouracil-5-percent-cream-associated-with-severe-neutropenia-discussion-of-a-case-and-review-of-systemic-reactions-after-topical-treatment-with-5-fluorouracil
#17
Philip R Cohen
5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. A 69-year-old man with a lower lip actinic keratosis developed severe neutropenia on day 11 of topical 5-fluorouracil treatment - after 14 applications. After receiving a subcutaneous injection of filgrastim, his neutrophil count normalized. The PubMed database was used to search the following terms: agranulocytosis, cream, 5-fluorouracil, granulocytopenia, neutropenia, severe, systemic, topical, and toxicity...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905986/bibliometric-analysis-of-100-most-cited-articles-on-oral-submucous-fibrosis
#18
Shailesh M Gondivkar, Sachin C Sarode, Amol R Gadbail, Rima S Gondivkar, Revant Chole, Gargi S Sarode
BACKGROUND: Citation analysis reflects the scientific recognition and influential performance of an article in the scientific community. The objective of this study was to identify and characterize the 100 most cited articles on oral submucous fibrosis (OSF). METHODS: A list of 100 most cited articles related to OSF was retrieved from the Science Citation Index-Expanded tool of Scopus database in May 2018.The articles were further reviewed, and basic information was recorded including the number of citations, citation density, journals, with its impact factor, category and quartile, publication year, authors, institution and country of origin, article type and level of evidence...
June 15, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29905958/epidemiology-of-hiv-drug-resistance-in-hiv-patients-with-virologic-failure-of-first-line-therapy-in-the-country-of-georgia
#19
Ekaterine Karkashadze, Natia Dvali, Natalia Bolokadze, Lali Sharvadze, Pati Gabunia, Marine Karchava, Tamar Tchelidze, Tengiz Tsertsvadze, Jack DeHovitz, Carlos Del Rio, Nikoloz Chkhartishvili
BACKGROUND: HIV drug resistance is a major threat to sustained impact of antiretroviral therapy (ART). We studied epidemiology of drug resistance in the country of Georgia. METHODS: Study included all adult patients who experienced virologic failure on first line ART and received HIV drug resistance testing between 2005-2016. Stanford HIV Sequence Database was used for interpretation of resistance data. Patient-level data were extracted from the national AIDS health information system...
June 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29905922/health-and-ecological-aspects-of-stray-cats-in-old-san-juan-puerto-rico-baseline-information-to-develop-an-effective-control-program
#20
Jessica Castro-Prieto, Maria José Andrade-Núñez
The overpopulation of stray cats in urban areas represents a potential risk for humans, as stray cats may carry diseases, such as toxoplasmosis, and virus such as rabies, the feline immunodeficiency, and the feline leukemia. In Old San Juan, a historic neighborhood and one of the most touristic places in Puerto Rico, there is an overpopulation of stray cats. In this study, we generated baseline information fundamental to developing a successful control program by estimating the stray cat population size, density, and spatial distribution...
June 2018: Puerto Rico Health Sciences Journal
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