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https://www.readbyqxmd.com/read/29677680/transcriptomic-identification-of-salt-related-genes-and-de-novo-assembly-in-common-buckwheat-f-esculentum
#1
Qi-Huan Lu, Ya-Qi Wang, Jin-Nan Song, Hong-Bing Yang
Common buckwheat (F. esculentum), annually herbaceous crop, is prevalent in people's daily life with the increasing development of economics. Compared with wheat, it is highly praised with high content of rutin and flavonoid. Common buckwheat is recognized as healthy food with good taste, and the product price of which such as noodles, flour, bread and so on are higher than wheat, and the seeds of which are bigger than that of tartary buckwheat, so if common buckwheat are planted more widely, people will spend less money on this healthy and delicious food...
April 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677583/grandparents-and-children-s-stunting-in-sub-saharan-africa
#2
Sandor Schrijner, Jeroen Smits
Globally an estimated 159 million children under 5 years of age are being too short for one's age (stunted). More than one third of these children is living in Africa. Given the substantial number of sub-Saharan African (SSA) children living in households with co-residing grandparents and the negative effects of stunting on productivity and economic growth, gaining insight into the role grandparents play for children's stunting, has become increasingly important. By applying multilevel logistic regression analysis on a database with information on 344,748 children aged 6-60 months living in 31 SSA countries, the strength of the relationship between grandparental co-residence and children's stunting is examined...
March 26, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29677562/effective-dose-calculation-program-edcp-for-the-usage-of-norm-added-consumer-product
#3
Do Hyeon Yoo, Jaekook Lee, Chul Hee Min
The aim of this study is to develop the Effective Dose Calculation Program (EDCP) for the usage of Naturally Occurring Radioactive Material (NORM) added consumer products. The EDCP was developed based on a database of effective dose conversion coefficient and the Matrix Laboratory (MATLAB) program to incorporate a Graphic User Interface (GUI) for ease of use. To validate EDCP, the effective dose calculated with EDCP by manually determining the source region by using the GUI and that by using the reference mathematical algorithm were compared for pillow, waist supporter, eye-patch and sleeping mattress...
April 9, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29677482/allosteric-ligands-for-the-pharmacologically-important-flavivirus-target-ns5-from-zinc-database-based-on-pharmacophoric-points-free-energy-calculations-and-dynamics-correlation
#4
Abbas Khan, Shoaib Saleem, Muhammad Idrees, Syed Shujait Ali, Muhammad Junaid, Aman Chandra Kaushik, Dong-Qing Wei
Dengue virus belongs to a group of human pathogens, which causes different diseases, dengue hemorrhagic fever and dengue shock syndrome in humans. It possesses RNA as a genetic material and is replicated with the aid of NS5 protein. RNA-dependent RNA polymerase (RdRp) is an important domain of NS5 in the replication of that virus. The catalytic process activity of RdRp is making it an important target for antiviral chemical therapy. To date, No FDA drug has been approved and marketed for the treatment of diseases caused by Dengue virus...
April 11, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29677458/intake-of-diacylglycerols-and-the-fasting-insulin-and-glucose-concentrations-a-meta-analysis-of-5-randomized-controlled-studies
#5
Xu Tongcheng, Jia Min, Li Xia, Qiu Bin, Zhang Yuan, Liu Wei, Zong Aizhen, Liu Lina, Du Fangling
Diacylglycerol (DAG) supplementation has been shown to be associated with the health improvement of patients with diabetes mellitus, although this efficacy is uncertain. We quantitatively examined the effect of dietary DAG on fasting serum glucose and insulin concentrations by conducting a meta-analysis of randomized controlled trials. Potential papers were initially searched from electronic databases of Medline, Embase, and Cochrane Library. Inclusion criteria required the trial to be randomized, with triacylglycerol (TAG) controlled with fasting serum glucose or insulin concentration as one of the end points...
April 20, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29677451/treatment-features-associated-with-youth-cognitive-behavioral-therapy-follow-up-effects-for-internalizing-disorders-a-meta-analysis
#6
Michael Sun, Leslie R Rith-Najarian, Timothy J Williamson, Bruce F Chorpita
Our aim was to investigate whether four treatment features (i.e., the inclusion of parental involvement, goal-setting strategies, maintenance/relapse prevention sessions, the addition of booster sessions) were associated with posttreatment and follow-up effect size of youth cognitive behavioral therapies (yCBTs) for anxiety, depression, posttraumatic stress disorder, and obsessive-compulsive disorder in age groups spanning young children to adolescents. We conducted a random-effects meta-analysis of 106 yCBTs tested in 76 randomized clinical trials from the PracticeWise Database to examine average effects of yCBTs posttreatment and at a later follow-up assessment...
April 20, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29677350/validating-variational-bayes-linear-regression-method-with-multi-central-datasets
#7
Hiroshi Murata, Linda M Zangwill, Yuri Fujino, Masato Matsuura, Atsuya Miki, Kazunori Hirasawa, Masaki Tanito, Shiro Mizoue, Kazuhiko Mori, Katsuyoshi Suzuki, Takehiro Yamashita, Kenji Kashiwagi, Nobuyuki Shoji, Ryo Asaoka
Purpose: To validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset. Method: The training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital. The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG) dataset consisted of 271 eyes of 177 patients, and the Diagnostic Innovations in Glaucoma Study (DIGS) dataset includes 248 eyes of 173 patients, which were used for validation...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677301/association-between-baseline-ldl-c-level-and-total-and-cardiovascular-mortality-after-ldl-c-lowering-a-systematic-review-and-meta-analysis
#8
Eliano P Navarese, Jennifer G Robinson, Mariusz Kowalewski, Michalina Kolodziejczak, Felicita Andreotti, Kevin Bliden, Udaya Tantry, Jacek Kubica, Paolo Raggi, Paul A Gurbel
Importance: Effects on specific fatal and nonfatal end points appear to vary for low-density lipoprotein cholesterol (LDL-C)-lowering drug trials. Objective: To evaluate whether baseline LDL-C level is associated with total and cardiovascular mortality risk reductions. Data Sourcesand Study Selection: Electronic databases (Cochrane, MEDLINE, EMBASE, TCTMD, ClinicalTrials.gov, major congress proceedings) were searched through February 2, 2018, to identify randomized clinical trials of statins, ezetimibe, and PCSK9-inhibiting monoclonal antibodies...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#9
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29677180/do-inhaled-corticosteroids-have-a-role-for-bronchiolitis
#10
Gonzalo Alarcón-Andrade, Lorena Cifuentes
INTRODUCTION: Bronchiolitis consists of an acute small airways inflammation secondary to a viral infection and is a frequent pathology among children under 2 years. The use of inhaled corticosteroids during bronchiolitis has been proposed to reduce recurrent wheeze or asthma, however there is controversy about it. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
April 17, 2018: Medwave
https://www.readbyqxmd.com/read/29677175/are-antipsychotics-effective-for-the-prevention-of-postoperative-delirium
#11
Viviana Castro, Rami Guinguis, Marcela Carrasco
INTRODUCTION: Antipsychotics have been proposed as a pharmacological alternative to prevent postoperative delirium. Nonetheless, their actual clinical benefits and harms are a matter of debate. METHODS: To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the chosen systematic reviews, reanalyzed the data from the primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
April 20, 2018: Medwave
https://www.readbyqxmd.com/read/29677173/what-does-this-mutation-mean-the-tools-and-pitfalls-of-variant-interpretation-in-lymphoid-malignancies
#12
REVIEW
Guillermin Yann, Lopez Jonathan, Chabane Kaddour, Hayette Sandrine, Bardel Claire, Salles Gilles, Sujobert Pierre, Huet Sarah
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individually tailored. Whilst translational research plays an important role in lymphoid malignancies, few guidelines exist to guide biologists and routine laboratories through this constantly evolving field. In this article, we review the challenges of interpreting HTS in lymphoid malignancies and provide a toolkit to interpret single nucleotide variants obtained from HTS...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677119/systematic-review-and-meta-analysis-of-a-proprietary-alpha-amylase-inhibitor-from-white-bean-phaseolus-vulgaris-l-on-weight-and-fat-loss-in-humans
#13
Jay Udani, Ollie Tan, Jhanna Molina
The aim of this meta-analysis was to examine the evidence for the effectiveness of a proprietary alpha-amylase inhibitor from white bean ( Phaseolus vulgaris L.) supplementation interventions in humans on modification of body weight and fat mass. A systematic literature search was performed using three databases: PubMed, the Cochrane collaboration, and Google Scholar. In addition, the manufacturer was contacted for internal unpublished data, and finally, the reference section of relevant original research and review papers were mined for additional studies...
April 20, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29677070/heavy-alcohol-use-among-deceased-donors-does-not-impact-recipient-outcomes-after-liver-transplantation
#14
Sumant S Arora, Khushdeep S Chahal, Page Axley, Devin E Eckhoff, Yong-Fang Kuo, Sanjaya K Satapathy, Russell Wiesner, Ashwani K Singal
BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks/day) are scanty. METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with not heavy drinking (ND) donors. RESULTS: Of 56 182 first LTs performed in the US for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677068/health-care-costs-for-the-evaluation-surgery-and-follow-up-care-of-living-kidney-donors
#15
Steven Habbous, Sisira Sarma, Lianne Barnieh, Eric McArthur, Scott Klarenbach, Braden Manns, Mehmet A Begen, Krista L Lentine, Amit X Garg
BACKGROUND: The health care costs to evaluate, perform surgery, and follow a living kidney donor for the year after donation are poorly described. METHODS: We obtained information on the health care costs of 1099 living kidney donors between April 1, 2004 and March 31, 2014 from Ontario, Canada using comprehensive health care administrative databases. We estimated the cost of 3 periods of the living donation process: the predonation evaluation period (start of evaluation until the day before donation), perioperative period (day of donation until 30-days postdonation), and 1 year of follow-up period (after perioperative period until 1-year postdonation)...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677012/inverse-correlation-between-daily-outdoor-temperature-and-blood-pressure-in-six-us-cities
#16
Jennifer M Radin, Daniel Neems, Ross Goglia, Khan Siddiqui, Steven R Steinhubl
This study aims to evaluate the relationship between mean outdoor temperature and mean daily blood pressure (BP) and heart rate (HR) among six, large, geographically and climatically diverse US cities. We collected BP and HR data from Higi stations, located in a wide range of neighborhood grocery stores and retail pharmacies, from six US cities (Houston, Los Angeles, Miami, Boise, Chicago, and New York City). Outdoor daily temperature data were collected from the National Centers for Environmental Information's database...
April 19, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29677001/impact-of-intravenous-acetaminophen-on-perioperative-opioid-utilization-and-outcomes-in-open-colectomies-a-claims-database-analysis
#17
Isaac Wasserman, Jashvant Poeran, Nicole Zubizarreta, Jason Babby, Stelian Serban, Andrew T Goldberg, Alexander J Greenstein, Stavros G Memtsoudis, Madhu Mazumdar, Andrew B Leibowitz
BACKGROUND: The value of intravenous acetaminophen in postoperative pain management remains debated. The authors tested the hypothesis that intravenous acetaminophen use, in isolation and in comparison to oral, would be associated with decreased opioid utilization (clinically significant reduction defined as 25%) and opioid-related adverse effects in open colectomy patients. METHODS: Using national claims data from open colectomy patients (Premier Healthcare Database, Premier Healthcare Solutions, Inc...
April 20, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29676997/mining-tcga-database-for-genes-of-prognostic-value-in-glioblastoma-microenvironment
#18
Di Jia, Shenglan Li, Dali Li, Haipeng Xue, Dan Yang, Ying Liu
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and database mining for potential correlation between genes and overall survival of a variety of malignancies including GBM. Previous reports have shown that tumor microenvironment cells and the extent of infiltrating immune and stromal cells in tumors contribute significantly to prognosis. Immune scores and stromal scores calculated based on the ESTIMATE algorithm could facilitate the quantification of the immune and stromal components in a tumor...
April 16, 2018: Aging
https://www.readbyqxmd.com/read/29676976/compliance-of-randomized-clinical-trials-in-noncarious-cervical-lesions-with-the-consort-statement-a-systematic-review-of-methodology
#19
A Reis, J L de Geus, L Wambier, M Schroeder, A D Loguercio
The literature was reviewed to evaluate the compliance of randomized clinical trials (RCTs) with the CONsolidated Standards of Reporting Trials (CONSORT ) and the risk of bias of these studies through the Cochrane Collaboration risk of bias tool (CCRT). RCTs were searched at Cochrane Library, PubMed, and other electronic databases to find studies about adhesive systems for cervical lesions. The compliance of the articles with CONSORT was evaluated using the following scale: 0 = no description, 1 = poor description, and 2 = adequate description...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676960/psychotherapy-targeting-depression-and-anxiety-for-use-in-palliative-care-a-meta-analysis
#20
Jessica J Fulton, Amie R Newins, Laura S Porter, Katherine Ramos
BACKGROUND: Research on the effectiveness of evidence-based practices in the treatment of depression and anxiety with palliative care populations is primarily limited to individuals having specific conditions such as cancer. OBJECTIVE: This meta-analysis examined the effect of psychotherapy on depression and anxiety among individuals with any condition appropriate for palliative care. METHODS: We searched PubMed, PsycINFO, Cochrane Library, and EMBASE databases until August 2017...
April 20, 2018: Journal of Palliative Medicine
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