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Cynthia do Prado Vendruscolo, Juliana Junqueira Moreira, Sarah Raphaela Torquato Seidel, Joice Fülber, Henrique Macedo Neuenschwander, Giancarlo Bonagura, Fernanda Rodrigues Agreste, Raquel Yvonne Arantes Baccarin
OBJECTIVE: The aim of this study was to verify whether transient inflammatory reactions induced by intra-articular medicinal ozone administration affect joint components, by in vivo evaluation of inflammatory (prostaglandin E2, Substance P, Interleukin-6, Interleukine-1, Tumor Necrosis Factor), anti-inflammatory (Interleukin-10) and oxidative (superoxide dismutase activity and oxidative burst) biomarkers and extracellular matrix degradation products (chondroitin sulphate and hyaluronic acid) in synovial fluid...
2018: PloS One
A Barone, M Otero-Losada, A M Grangeat, G Cao, F Azzato, A Rodríguez, J Milei
BACKGROUND: In-stent restenosis and poor re-endothelization usually follow percutaneous transluminal coronary angioplasty, even using drug-eluting stents, due to inflammation and oxidative stress. Medical ozone has antioxidant and anti-inflammatory properties and has not been evaluated in this context. OBJECTIVES: To evaluate whether ozonotherapy might reduce restenosis following bare metal stents implantation in relation to the redoxin system in pigs. METHODS: Twelve male Landrace pigs (51±9kg) underwent percutaneous transluminal circumflex coronary arteries bare metal stent implantation under heparine infusion and fluoroscopical guidance, using standard techniques...
November 15, 2016: International Journal of Cardiology
(no author information available yet)
This study was designed to estimate the influence of ozone therapy on oxygen metabolism kinetics and the circulation system during spa and resort treatment of 145 post-infarction patients who survived myocardial infarction. All of them were given routine spa-and-resort therapy; 56 patients received pharmacotherapy, in the remaining 89 it was supplemented with ozone-therapy. The clinical examination included electrocardiography, veloergometry, echocardiography; kinetics of oxygen metabolism was evaluated by transcutaneous polarography, laser Doppler flowmetry, and computed capillaroscopy...
November 2013: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Emma Borrelli, Velio Bocci
The dry form of ARMD is becoming a serious problem because of the rise in the number of old individuals. No effective therapy is available in dry ARMD except for the illusory oral administration of antioxidant vitamins. Despite scepticism in the medical community, the therapeutic effect of ozonetherapy had been evaluated since 1996. This evaluation has been based on specific biochemical, molecular and pharmacological reactions. Nevertheless a number of visual scientists continue to ignore ozonetherapy conservatively and prescribe only antioxidant vitamins...
2013: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Velio Bocci, Iacopo Zanardi, Maya S P Huijberts, Valter Travagli
It is now well established that hyperglycemia, present in both type 1 and type 2 diabetes, causes a variety of biochemical derangements leading to a diffused vascular damage responsible for several pathologic manifestations. Although preclinical and clinical studies have been performed by an unreliable administration route, the correct approach of oxygen-ozonetherapy may break a vicious circle. Messengers, released by a precise interaction ex vivo of the patient's blood with an equivalent calculated dose of ozone (0...
January 2011: Diabetes & Metabolic Syndrome
Velio Bocci
It is proposed to discuss how ozonetherapy acts on patients affected by vascular and degenerative diseases. Ozone is a strong oxidant but, if used in small dosages on human blood ex vivo, acts as an acceptable stressor. By instantly reacting with PUFA bound to albumin, ozone is entirely consumed but generates two messengers acting in an early and in a late phase: the former is due to hydrogen peroxide, which triggers biochemical pathways on blood cells and the latter is due to alkenals which are infused into the donor patient...
September 2012: Free Radical Research
B A Agaev, R M Agaev, R Sh Gasymov
The internal draining of biliary tracts of patients with obstructive jaundice and acute cholangitis is considered most acceptable, but deficiency of this method is anastomosis failure, stricture and purulent-septic complications hazard. The investigations performed on 79 patients with obstructive jaundice, 36 of which were included in control group, 43 - in main group. To patients of main group with internal draining intraoperatively through the nose and biliodigestive anastomosis into the biliary tract transmitted tube with quartz optical monofiber for endocholedocheal laser irradiation in one lumen and hollow other, serve for drainage and irrigation of bile-excreting way with ozonized physiological solution...
2011: Khirurgiia
Velio Bocci, Iacopo Zanardi, Valter Travagli
During the last century the lifespan of human beings has increased from about 49 to almost 80 years owing to the great advances of biomedical sciences. This fact has strongly stimulated the idea that it may be possible to prolong productive life for another twenty years but paradoxically the problem of both hyper- and hyponutrition severely jeopardizes this objective all over the world. Many causes of premature aging have been discussed in order to prevent it or find suitable medical treatment. So far only a moderate restriction of caloric intake that does not alter essential nutrients has proved capable of keeping animals and humans healthier for a prolonged time...
December 2010: Current Aging Science
T G Shcherbatiuk
The results of experimental and clinical researches on studying biological effects of ozonetherapy were observed. Modem ozonetherapy methods and ways, indications and contra-indications the use of this method of oxidizing therapy were described. The ozonetherapy problems were analysed and offers on prospects of development ozone technologies in biomedicine were stated.
2008: Fiziolohichnyĭ Zhurnal
Iu R Efremenko
The effect of ozonated saline on proteolytic enzymes: trypsin, chymotrypsin, elastase, kallikrein, leucine aminopeptidase, inhibitors of proteolysis and lipid peroxidation has been investigated. Injection of ozonated saline led to significal response of proteolytic system. Ozonated saline with low ozone doses produced a positive effect on proteolytic system. High doses of ozone produced significal reinforcement of proteolytic system and the decrease of alpha1-antitrypsin and alpha2-macroglobulin activity in blood plasma...
March 2008: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
V Bocci
Immunoregulatory cytokines produced by the TH1 subset and by CD8(+) T lymphocytes appear to brake naturally and sometimes arrest the progress of HIV infection in the early phase. It appears reasonable to assume that a mild and equilibrated stimulation of the immune system may prevent or delay the fatal transition towards the prevalent production of TH2-type cytokines. The problem is how to stimulate the immune system in a physiological fashion. In the last 7 years we have clarified the main mechanisms of action of an unorthodox immunotherapeutic method first used 40 years ago...
1994: Mediators of Inflammation
V Bocci
Ozone is a very reactive gas that is toxic to the respiratory system. However, under controlled conditions, it can be therapeutically useful in several human diseases. An unfavourable combination of factors (ozone is one of the worst troposphere pollutants) and past misuse have led to misgivings about ozonetherapy. However, basic and clinical work developed over the past 10 years has clarified the fundamental mechanisms of action of ozone in biology and medicine. Interestingly, judicious doses of ozone dissolved in blood trigger a cascade of well-defined chemical compounds acting on multiple cellular targets according to well-known molecular, biochemical and pharmacological pathways...
2007: British Journal of Biomedical Science
Velio Bocci
There are a number of good experimental studies showing that exposure by inhalation to prolonged tropospheric ozone damages the respiratory system and extrapulmonary organs. The skin, if extensively exposed, may also contribute to the damage. The undoubtful strong reactivity of ozone has contributed to establish the dogma that ozone is always toxic and its medical application must be proscribed. Although it is less known, judiciously practiced ozonetherapy is becoming very useful either on its own or applied in combination with orthodox medicine in a broad range of pathologies...
November 1, 2006: Toxicology and Applied Pharmacology
Valter Travagli, Iacopo Zanardi, Velio Bocci
We have clarified the role of the ozone concentration in relation to the resistance of human erythrocytes in whole human blood or in blood diluted either in saline or in distilled water. Spectrophotometric data related to haemoglobin were evaluated by exposing samples of fresh human blood directly to ozone doses (ratio 1:1 volume), within the therapeutic range (0.21-1.68 mM) and to one toxic dose (3.36 mM). Furthermore, the same determinations have been carried out after previous dilution of the same blood with either pure water or physiological saline (1 ml blood + 29 ml diluent) followed by ozonation with the above reported ozone doses...
November 15, 2006: International Journal of Biological Macromolecules
Bernardino Clavo, Ana Ruiz, Marta Lloret, Laura López, Gerardo Suárez, David Macías, Victor Rodríguez, Maria A Hernández, Roberto Martín-Oliva, Santiago Quintero, José M Cuyás, Francisco Robaina
Advanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H&N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 19 patients with advanced H&N tumors who were undergoing treatment in our department with non-standard fractionated radiotherapy plus oral tegafur...
December 2004: Evidence-based Complementary and Alternative Medicine: ECAM
V Bocci, C Aldinucci
We are proposing to evaluate whether a complementary approach based on cycles of oxygen-ozone autohemotherapy (O3-AHT) already performed in millions of patients, can abate the chronic oxidative stress and improve the quality of life of serious hemoglobinopathic patients. Although a preliminary study has yielded encouraging results, it appears appropriate to perform a controlled, randomized and possibly multicentre clinical trial. The long use of this approach in other pathologies has proved to be very useful and it is hoped that scepticism will not prevail over scientific rationale...
January 2004: Journal of Biological Regulators and Homeostatic Agents
M Foksinski, K Bialkowski, M Skiba, I Ponikowska, W Szmurlo, R Olinski
In the present study we measured the amount of 8-oxo-2'-deoxyguanosine (8-oxo-dG) in DNA isolated from lymphocytes of arteriosclerotic patients undergoing ozonetherapy. Treatment of the patients with therapeutic concentration of ozone caused a significant increase over the control value in the amount of 8-oxo-dG of DNA isolated from their lymphocytes. However, only three out of six patients examined responded positively to the treatment in terms of the base damage. The increases varied among patients, and were in the range of 100-450%...
January 2, 1999: Mutation Research
V Bocci
The disinfectant activity of ozone is well recognized and ozone is used worldwide for sterilization of water. The use of ozone as a complementary medical approach is less known, because it has mostly been used in an empirical fashion without a rational basis and appropriate controls. In spite of this drawback, the use of judicious and standardized ozone dosages can elicit the formation of ROS acting as natural physiological activators of several biological functions. There is now a reasonable understanding of a few mechanisms of action and, using classical pharmacological concepts, it appears possible to formulate a rationale for optimizing clinical applications...
April 1996: Journal of Biological Regulators and Homeostatic Agents
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