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https://www.readbyqxmd.com/read/28621139/coupling-urinary-trihalomethanes-and-metabolomic-profiles-of-type-ii-diabetes-a-case-control-study
#1
Xanthi D Andrianou, Pantelis Charisiadis, Konstantinos Christos Makris
Abiding by the exposome paradigm, incorporation of external and internal exposure metrics using metabolomics tools is warranted to refine the etiology of type II diabetes (T2D). A small (n=51) age- and sex-matched case-control study was conducted in Cyprus coupling urinary trihalomethanes (THM) with T2D. The objectives were to: i) perform a comparative assessment of different deconvolution parameters in compound identification, and ii) evaluate the association between differentially expressed metabolites and either urinary THM or T2D status...
June 16, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28528799/a-multifactorial-obesity-model-developed-from-nationwide-public-health-exposome-data-and-modern-computational-analyses
#2
LisaAnn S Gittner, Barbara J Kilbourne, Ravi Vadapalli, Hafiz M K Khan, Michael A Langston
STATEMENT OF THE PROBLEM: Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity. METHODS: Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity...
May 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28520403/integrated-strategy-for-unknown-ei-ms-identification-using-quality-control-calibration-curve-multivariate-analysis-ei-ms-spectral-database-and-retention-index-prediction
#3
Teruko Matsuo, Hiroshi Tsugawa, Hiromi Miyagawa, Eiichiro Fukusaki
Compound identification using unknown electron ionization (EI) mass spectra in gas chromatography coupled with mass spectrometry (GC-MS) is challenging in untargeted metabolomics, natural product chemistry, or exposome research. While the total count of EI-MS records included in publicly or commercially available databases is over 900 000, efficient use of this huge database has not been achieved in metabolomics. Therefore, we proposed a "four-step" strategy for the identification of biologically significant metabolites using an integrated cheminformatics approach: (i) quality control calibration curve to reduce background noise, (ii) variable selection by hypothesis testing in principal component analysis for the efficient selection of target peaks, (iii) searching the EI-MS spectral database, and (iv) retention index (RI) filtering in combination with RI predictions...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28494612/oxidative-stress-and-inflammation-induced-by-environmental-and-psychological-stressors-a-biomarker-perspective
#4
Pietro Ghezzi, Luciano Floridi, Diana Boraschi, Antonio Cuadrado, Gina Manda, Snezana Levic, Fulvio D'Acquisto, Alice Hamilton, Toby J Athersuch, Liza Selley
SIGNIFICANCE: The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. Recent Advances: By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions...
June 15, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28494538/the-exposome-and-the-future-of-epidemiology-a-vision-and-prospect
#5
Kyoung-Nam Kim, Yun-Chul Hong
It is widely accepted that relatively small parts of chronic diseases can be explained by genetic factors alone. Although environmental exposures are important to evaluate chronic diseases comprehensively, they are not assessed with sufficient comprehensiveness and accuracy in contrast to genome. To emphasize the importance of more complete evaluation of environmental exposure, the concept of exposome, which indicates the entirety of environmental exposure from conception onwards, was introduced in 2005. Since 2010s, several epidemiological studies, such as the Human Early-Life Exposome (HELIX) project, have applied the exposome concept...
May 3, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28422130/assessment-of-metabolic-phenotypic-variability-in-children-s-urine-using-1-h-nmr-spectroscopy
#6
Léa Maitre, Chung-Ho E Lau, Esther Vizcaino, Oliver Robinson, Maribel Casas, Alexandros P Siskos, Elizabeth J Want, Toby Athersuch, Remy Slama, Martine Vrijheid, Hector C Keun, Muireann Coen
The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using (1)H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children aged 8-9 years old. Daily spot morning, night-time and pooled (50:50 morning and night-time) urine samples across six days (18 samples per child) were analysed, and 44 metabolites quantified...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420222/how-sensors-might-help-define-the-external-exposome
#7
REVIEW
Miranda Loh, Dimosthenis Sarigiannis, Alberto Gotti, Spyros Karakitsios, Anjoeka Pronk, Eelco Kuijpers, Isabella Annesi-Maesano, Nour Baiz, Joana Madureira, Eduardo Oliveira Fernandes, Michael Jerrett, John W Cherrie
The advent of the exposome concept, the advancement of mobile technology, sensors, and the "internet of things" bring exciting opportunities to exposure science. Smartphone apps, wireless devices, the downsizing of monitoring technologies, along with lower costs for such equipment makes it possible for various aspects of exposure to be measured more easily and frequently. We discuss possibilities and lay out several criteria for using smart technologies for external exposome studies. Smart technologies are evolving quickly, and while they provide great promise for advancing exposure science, many are still in developmental stages and their use in epidemiology and risk studies must be carefully considered...
April 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28384083/assessing-the-exposome-with-external-measures-commentary-on-the-state-of-the-science-and-research-recommendations
#8
Michelle C Turner, Mark Nieuwenhuijsen, Kim Anderson, David Balshaw, Yuxia Cui, Genevieve Dunton, Jane A Hoppin, Petros Koutrakis, Michael Jerrett
The exposome comprises all environmental exposures that a person experiences from conception throughout the life course. Here we review the state of the science for assessing external exposures within the exposome. This article reviews (a) categories of exposures that can be assessed externally, (b) the current state of the science in external exposure assessment, (c) current tools available for external exposure assessment, and (d) priority research needs. We describe major scientific and technological advances that inform external assessment of the exposome, including geographic information systems; remote sensing; global positioning system and geolocation technologies; portable and personal sensing, including smartphone-based sensors and assessments; and self-reported questionnaire assessments, which increasingly rely on Internet-based platforms...
March 20, 2017: Annual Review of Public Health
https://www.readbyqxmd.com/read/28383921/icp-ms-ms-based-ionomics-a-validated-methodology-to-investigate-the-biological-variability-of-the-human-ionome
#9
Tobias Konz, Eugenia Migliavacca, Loïc Dayon, Gene Bowman, Aikaterini Oikonomidi, Julius Popp, Serge Rezzi
We here describe the development, validation and application of a quantitative methodology for the simultaneous determination of 29 elements in human serum using state-of-the-art inductively coupled plasma triple quadrupole mass spectrometry (ICP-MS/MS). This new methodology offers high-throughput elemental profiling using simple dilution of minimal quantity of serum samples. We report the outcomes of the validation procedure including limits of detection/quantification, linearity of calibration curves, precision, recovery and measurement uncertainty...
May 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28383342/the-children-s-health-exposure-analysis-resource-enabling-research-into-the-environmental-influences-on-children-s-health-outcomes
#10
David M Balshaw, Gwen W Collman, Kimberly A Gray, Claudia L Thompson
PURPOSE OF REVIEW: The Children's Health Exposure Analysis Resource (CHEAR) is a new infrastructure supported by the National Institute of Environmental Health Sciences to expand the ability of children's health researchers to include analysis of environmental exposures in their research and to incorporate the emerging concept of the exposome. RECENT FINDINGS: There is extensive discussion of the potential of the exposome to advance understanding of the totality of environmental influences on human health...
June 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28377395/integrated-approach-of-nutritional-and-molecular-epidemiology-mineralogical-and-chemical-pollutant-characterisation-the-protocol-of-a-cross-sectional-study-in-women
#11
Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Germana Barone, Paolo Mazzoleni, Alfio Catalfo, Guido De Guidi, Maria Iemmolo, Nunzio Crimi, Antonella Agodi
INTRODUCTION: Environmentally-related health and disease are the result of the exposome, the totality of a person's environmental exposures, from all sources and routes, across their lifespan. Epigenetic phenomena, including DNA methylation, can be potentially modified by environmental and lifestyle factors, and result in environmental reprogramming of the genome for exposed individuals and for future generations of offspring. OBJECTIVE: The objective of the project is to evaluate the risk of DNA hypomethylation due to air pollution, Mediterranean diet adherence, folate intake, and demographic and socioeconomic factors, in healthy women living in the metropolitan area of Catania, Italy...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28362625/a-blend-of-old-and-new-biomonitoring-methods-to-study-the-exposome
#12
Rachel Cernansky
No abstract text is available yet for this article.
March 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28360887/oxidative-stress-function-in-women-over-40%C3%A2-years-of-age-considering-their-lifestyle
#13
Maria Paula Gonçalves Mota, Zirlene Santos, Jorge Soares, Ana Pereira, Sandra Fonseca, Francisco Peixoto, Isabel Gaivão, Maria Oliveira
Aging is dependent on biological processes that determine the aging of the organism at the cellular level. The Oxidative Stress Theory of Aging might explain some of the age-related changes in cell macromolecules. Moreover, exposome and lifestyle may also induce changes in cell damage induced by oxidative stress. The aim of the present study was to analyze the related redox changes in lymphocyte function of healthy women over 40 years old. Three groups: younger (YG: 40-49 years), middle aged (MAG: 50-59 years), and older (OG: ≥60 years) were evaluated on anthropometric variables, blood pressure, cardiovascular fitness, lifestyle habits, perceived stress, DNA damage, malondialdehyde, catalase activity, and total antioxidant capacity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28291591/the-inma-infancia-y-medio-ambiente-environment-and-childhood-project-more-than-10-years-contributing-to-environmental-and-neuropsychological-research
#14
REVIEW
Mireia Gascon, Mònica Guxens, Martine Vrijheid, Maties Torrent, Jesús Ibarluzea, Eduardo Fano, Sabrina Llop, Ferran Ballester, Mariana F Fernández, Adonina Tardón, Ana Fernández-Somoano, Jordi Sunyer
BACKGROUND: In 2003 the INMA-INfancia y Medio Ambiente (Environment and Childhood) project, a Spanish national network of birth cohorts including more than 3500 participants, was set up with the aim to assess the health impacts of pre- and postnatal environmental exposures on children. The project has published more than 60 papers on maternal and environmental factors related to neuropsychological development in children, one of the main research interests within the project. With the present review, we evaluate the evidence provided by the INMA project on this topic and discuss how the data can contribute to cover the challenges that children's environmental health research will face in the coming years...
February 28, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28284980/the-kingston-allergy-birth-cohort-exploring-parentally-reported-respiratory-outcomes-through-the-lens-of-the-exposome
#15
Michelle L North, Jeffrey R Brook, Elizabeth Y Lee, Vanessa Omana, Nadia M Daniel, Lisa M Steacy, Greg J Evans, Miriam L Diamond, Anne K Ellis
BACKGROUND: The Kingston Allergy Birth Cohort (KABC) is a prenatally recruited cohort initiated to study the developmental origins of allergic disease. Kingston General Hospital was chosen for recruitment because it serves a population with notable diversity in environmental exposures relevant to the emerging concept of the exposome. OBJECTIVE: To establish a profile of the KABC using the exposome framework and examine parentally reported respiratory symptoms to 2 years of age...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28284820/current-pesticide-profiles-in-blood-serum-of-adults-in-jiangsu-province-of-china-and-a-comparison-with-other-countries
#16
Chunxin Chang, Minjian Chen, Jiawei Gao, Jia Luo, Keqin Wu, Tianyu Dong, Kun Zhou, Xiaowei He, Weiyue Hu, Wei Wu, Chuncheng Lu, Bo Hang, John D Meeker, Xinru Wang, Yankai Xia
Although various pesticides were used globally, the pesticides profiles in human blood serum remain largely unknown. We determined pesticide exposure profiles using solid-phase extraction and gas chromatography tandem with triple quadrupole mass spectrometry in 200 human blood serum samples from the adult population in Jiangsu Province, China. A systematic and comprehensive literature review was carried out to identify the articles investigating pesticide exposure and compare exposure data. Of the 88 pesticides, 76 were found in the blood serum of the population in Jiangsu Province...
March 8, 2017: Environment International
https://www.readbyqxmd.com/read/28266605/in-vivo-microsampling-to-capture-the-elusive-exposome
#17
Vincent Bessonneau, Jennifer Ings, Mark McMaster, Richard Smith, Leslie Bragg, Mark Servos, Janusz Pawliszyn
Loss and/or degradation of small molecules during sampling, sample transportation and storage can adversely impact biological interpretation of metabolomics data. In this study, we performed in vivo sampling using solid-phase microextraction (SPME) in combination with non-targeted liquid chromatography and high-resolution tandem mass spectrometry (LC-MS/MS) to capture the fish tissue exposome using molecular networking analysis, and the results were contrasted with molecular differences obtained with ex vivo SPME sampling...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251040/analytic-complexity-and-challenges-in-identifying-mixtures-of-exposures-associated-with-phenotypes-in-the-exposome-era
#18
REVIEW
Chirag J Patel
PURPOSE OF REVIEW: Mixtures, or combinations and interactions between multiple environmental exposures, are hypothesized to be causally linked with disease and health-related phenotypes. Established and emerging molecular measurement technologies to assay the exposome, the comprehensive battery of exposures encountered from birth to death, promise a new way of identifying mixtures in disease in the epidemiological setting. In this opinion, we describe the analytic complexity and challenges in identifying mixtures associated with phenotype and disease...
2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28240728/%C3%AF-%C3%AF-occupational-medicine-in-italian-academy-what-future
#19
Pietro Apostoli
The entire Italian University system, including the whole field of medical teaching and research, is currently passing through a period of cumbersome changes due to the many difficulties encountered in its reform process. Academic occupational medicine is deeply involved in this process that resembles a real crisis. Given this background, this contribution - written as President of the Italian College of Occupational Medicine Full Professors - has the main objective to open a debate about the current generalized crisis of our Academic Discipline and about its possible future developments...
February 15, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28231548/spatiotemporal-exposome-dynamics-of-soil-lead-and-children-s-blood-lead-pre-and-ten-years-post-hurricane-katrina-lead-and-other-metals-on-public-and-private-properties-in-the-city-of-new-orleans-louisiana-u-s-a
#20
Howard W Mielke, Christopher R Gonzales, Eric T Powell, Paul W Mielke
BACKGROUND: Anthropogenic re-distribution of lead (Pb) principally through its use in gasoline additives and lead-based paints have transformed the urban exposome. This unique study tracks urban-scale soil Pb (SPb) and blood Pb (BPb) responses of children living in public and private communities in New Orleans before and ten years after Hurricane Katrina (29 August 2005). OBJECTIVES: To compare and evaluate associations of pre- and ten years post-Katrina SPb and children's BPb on public and private residential census tracts in the core and outer areas of New Orleans, and to examine correlations between SPb and nine other soil metals...
May 2017: Environmental Research
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