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Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo, Nikolaos N Louros, Emiel Michiels, Reshmi Ramakrishnan, Meine Ramakers, Filip Claes, Lydia Young, Mohammad Shahrooei, Hannah Wilkinson, Matyas Desager, Wubishet Mengistu Tadesse, K Peter R Nilsson, Per Hammarström, Abram Aertsen, Sebastien Carpentier, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz
Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When aggregation is nucleated in bacteria by such frequently occurring APRs, it leads to massive and lethal inclusion body formation containing a large number of proteins. Buildup of bacterial resistance against these peptides is slow...
February 28, 2018: Nature Communications
S Khodaparast, O Atasi, A Deblais, B Scheid, H A Stone
As an air bubble translates in a microchannel, a thin film of liquid is formed on the bounding walls. In a microchannel with a rectangular cross-section, the liquid in the film leaks toward the low-pressure corners of the geometry, which leads to the appearance of local minima in the film thickness in the cross-sectional plane. In such a configuration, theory suggests that the minimum film thickness scales with Ca and Ca4/3 depending on the distance from the nose of the bubble, where Ca = μUb /γ is the flow capillary number based on the bubble velocity Ub , liquid viscosity μ, and surface tension γ, and Ca ≪ 1...
January 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Nan Xue, Sepideh Khodaparast, Lailai Zhu, Janine K Nunes, Hyoungsoo Kim, Howard A Stone
Inducing thermal gradients in fluid systems with initial, well-defined density gradients results in the formation of distinct layered patterns, such as those observed in the ocean due to double-diffusive convection. In contrast, layered composite fluids are sometimes observed in confined systems of rather chaotic initial states, for example, lattes formed by pouring espresso into a glass of warm milk. Here, we report controlled experiments injecting a fluid into a miscible phase and show that, above a critical injection velocity, layering emerges over a time scale of minutes...
December 12, 2017: Nature Communications
Mohammadreza Khalaj, Mohammadreza Kamali, Zahra Khodaparast, Akram Jahanshahi
Synthesis of the various types of engineered nanomaterials has gained a huge attention in recent years for various applications. Copper based nanomaterials are a branch of this category seem to be able to provide an efficient and cost-effective way for the treatment of the persistent effluents. The present work aimed to study the various parameters may involve in the overall performance of the copper based nanomaterials for environmental clean-up purposes. To this end, the related characteristics of copper based nanomaterials and their effects on the nanomaterials reactivity and the environmental and operating parameters have been critically reviewed...
February 2018: Ecotoxicology and Environmental Safety
Sepideh Khodaparast, François Boulogne, Christophe Poulard, Howard A Stone
Inks of permanent markers and waterproof cosmetics create elastic thin films upon application on a surface. Such adhesive materials are deliberately designed to exhibit water-repellent behavior. Therefore, patterns made up of these inks become resistant to moisture and cannot be cleaned by water after drying. However, we show that sufficiently slow dipping of such elastic films, which are adhered to a substrate, into a bath of pure water allows for complete removal of the hydrophobic coatings. Upon dipping, the air-water interface in the bath forms a contact line on the substrate, which exerts a capillary-induced peeling force at the edge of the hydrophobic thin film...
October 13, 2017: Physical Review Letters
Benedicte Eneman, Mohamed A Elmonem, Lambertus P van den Heuvel, Laleh Khodaparast, Ladan Khodaparast, Chris van Geet, Kathleen Freson, Elena Levtchenko
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in children with nephrotic syndrome (NS), associated with increased platelet count and aggregability and increased risk of thrombosis. To further study PACAP deficiency in NS, we used transgenic Tg(cd41:EGFP) zebrafish with GFP-labeled thrombocytes. We generated two models for congenital NS, a morpholino injected model targeting nphs1 (nephrin), which is mutated in the Finnish-type congenital NS...
2017: PloS One
François Boulogne, Sepideh Khodaparast, Christophe Poulard, Howard A Stone
This work aims to identify common challenges in the preparation of the blister test devices designed for the measurement of the energy release rate for brittle thin films and to propose easy-to-implement solutions accordingly. To this end, we provide a step-by-step guide for fabricating a blister test device comprised of thin polystyrene films adhered to glass substrates. Thin films are first transferred from donor substrates to an air-water interface, which is then used as a platform to locate them on a receiver substrate...
June 2017: European Physical Journal. E, Soft Matter
Yingxian Estella Yu, Sepideh Khodaparast, Howard A Stone
We study the process of coating the interface of a long gas bubble, which is translating in a horizontal circular capillary tube filled with a colloidal suspension. A typical elongated confined bubble is comprised of three distinct regions: a spherical front cap, a central body that is separated from the tube wall by a thin liquid film, and a spherical cap at the back. These three regions are connected by transitional sections. Particles gradually coat the bubble from the back to the front. We investigate the mechanisms that govern the initial accumulation of the particles and the growth of the particle-coated area on the interface of the bubble...
April 12, 2017: Soft Matter
Mohamed A Elmonem, Ramzi Khalil, Ladan Khodaparast, Laleh Khodaparast, Fanny O Arcolino, Joseph Morgan, Anna Pastore, Przemko Tylzanowski, Annelii Ny, Martin Lowe, Peter A de Witte, Hans J Baelde, Lambertus P van den Heuvel, Elena Levtchenko
The human ubiquitous protein cystinosin is responsible for transporting the disulphide amino acid cystine from the lysosomal compartment into the cytosol. In humans, Pathogenic mutations of CTNS lead to defective cystinosin function, intralysosomal cystine accumulation and the development of cystinosis. Kidneys are initially affected with generalized proximal tubular dysfunction (renal Fanconi syndrome), then the disease rapidly affects glomeruli and progresses towards end stage renal failure and multiple organ dysfunction...
February 15, 2017: Scientific Reports
Sepideh Khodaparast, Minyoung Kevin Kim, Justin E Silpe, Howard A Stone
Moving air-liquid interfaces, for example, bubbles, play a significant role in the detachment and transport of colloids and microorganisms in confined systems as well as unsaturated porous media. Moreover, they can effectively prevent and/or postpone the development of mature biofilms on surfaces that are colonized by bacteria. Here we demonstrate the dynamics and quantify the effectiveness of this bubble-driven detachment process for the bacterial strain Staphylococcus aureus. We investigate the effects of interface velocity and geometrical factors through microfluidic experiments that mimic some of the confinement features of pore-scale geometries...
February 7, 2017: Environmental Science & Technology
Zainab Moazzam, Jason Paquette, Austin R Duke, Navid Khodaparast, Paul B Yoo
OBJECTIVE: Implant-driven tibial nerve stimulation therapy is an effective technique for treating overactive bladder. However, the monopolar lead design in the currently available implantable devices pose long-term therapeutic challenges in terms of efficiently and selectively delivering electrical pulses to the target. Hence, the purpose of this study was to (1) characterize the tibial nerve (TN) activation properties using a multi-contact implantable system and (2) evaluate the long-term stability of using such a neural interface in a preclinical model...
April 2017: Urology
Rodrigo Gallardo, Meine Ramakers, Frederik De Smet, Filip Claes, Ladan Khodaparast, Laleh Khodaparast, José R Couceiro, Tobias Langenberg, Maxime Siemons, Sofie Nyström, Laurence J Young, Romain F Laine, Lydia Young, Enrico Radaelli, Iryna Benilova, Manoj Kumar, An Staes, Matyas Desager, Manu Beerens, Petra Vandervoort, Aernout Luttun, Kris Gevaert, Guy Bormans, Mieke Dewerchin, Johan Van Eldere, Peter Carmeliet, Greetje Vande Velde, Catherine Verfaillie, Clemens F Kaminski, Bart De Strooper, Per Hammarström, K Peter R Nilsson, Louise Serpell, Joost Schymkowitz, Frederic Rousseau
Most human proteins possess amyloidogenic segments, but only about 30 are associated with amyloid-associated pathologies, and it remains unclear what determines amyloid toxicity. We designed vascin, a synthetic amyloid peptide, based on an amyloidogenic fragment of vascular endothelial growth factor receptor 2 (VEGFR2), a protein that is not associated to amyloidosis. Vascin recapitulates key biophysical and biochemical characteristics of natural amyloids, penetrates cells, and seeds the aggregation of VEGFR2 through direct interaction...
November 11, 2016: Science
Hassan Goodarzi, Seyed-Masoud Khatami, Hammidreza Javadzadeh, Sadrollah Mahmoudi, Hojjatollah Khajehpour, Soleiman Heidari, Morteza Khodaparast, Ali Ebrahimi, Hamidreza Rasouli, Mohammadreza Ghane, Mehrdad Faraji, Kasra Hassanpour
BACKGROUND: Picture archiving and communication system (PACS) has allowed the medical images to be transmitted, stored, retrieved, and displayed in different locations of a hospital or health system. Using PACS in the emergency department will eventually result in improved efficiency and patient care. In spite of the abundant benefits of employing PACS, there are some challenges in implementing this technology like users' resistance to accept the technology, which has a critical role in PACS success...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Hesam Hashemian, Reza Mirshahi, Mehdi Khodaparast, Mahmoud Jabbarvand
PURPOSE: To investigate recent evidence in prophylaxis and management of post-cataract surgery endophthalmitis. METHODS: We conducted a literature search using Pubmed database for post cataract surgery endophthalmitis, and relevant articles were selected from original English papers published since 2015. RESULTS: Forty-nine articles were published regarding post-cataract surgery endophthalmitis from January 2015 to February 2016. A low incidence of post-cataract surgery endophthalmitis has been reported...
September 2016: Journal of Current Ophthalmology
Enayatollah Homaie Rad, Marzie Khodaparast
OBJECTIVE: Having progressive health finance mechanism is very important to decrease inequity in health systems. Revenue collection is one of the aspects of health care financing. In this study, taxation system and health insurance contribution of Iranians were assessed. MATERIALS AND METHODS: Data of 2012 household expenditures survey were used in this study, and payments of the families for health insurances and tax payments were extracted from the study. Kakwani index was calculated for assessing the progressivity of these payments...
June 2016: Eurasian Journal of Medicine
Mahmoud Jabbarvand, Hesam Hashemian, Mehdi Khodaparast, Pasha Anvari
PURPOSE: To evaluate the effects of photorefractive keratectomy (PRK) on the stereopsis of myopic and hyperopic patients. SETTING: Farabi Eye Hospital, Tehran, Iran. DESIGN: Prospective case series. METHODS: This study included patients having PRK to achieve emmetropia. The patients were divided into the following 3 groups: low myopia (<-6.0 diopters [D]), high myopia (>-6.0 D), and hyperopia (<+4.0 D). Near stereoacuity was measured using the Randot test under photopic conditions (with corrective glasses) at 40 cm preoperatively (with corrective glasses) and 1, 3, and 12 months postoperatively...
June 2016: Journal of Cataract and Refractive Surgery
Mohammad Yousef Alikhani, Fereshteh Shahcheraghi, Sepideh Khodaparast, Amir Sasan Mozaffari Nejad, Mojgan K Moghadam, Sayed Fazlollah Mousavi
BACKGROUND AND STUDY AIM: Colitis is a common complication after treatment with antibiotics such as β-lactams, quinolones, and aminoglycosides. Recently, Klebsiella oxytoca has been implicated in this type of diarrhoea. The prevalence and characterisations of K. oxytoca isolated from patients with antibiotic-associated diarrhoea were investigated. The K. oxytoca isolates were also tested for cytotoxin production. PATIENTS AND METHODS: This study was conducted from May 2011 to Dec 2013...
June 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Ladan Khodaparast, Laleh Khodaparast, Lieve Van Mellaert, Mohammad Shahrooei, Marc Van Ranst, Johan Van Eldere
Staphylococcus epidermidis is one of the major concerns with respect to hospital-acquired infections. Therefore, a rapid and easy method to identify at species level S. epidermidis isolates out of a broad range of bacteria is necessary. Based on earlier studies, the sesC gene encoding a S. epidermidis surface protein revealed to be a highly conserved gene in this species. By means of an easy and inexpensive PCR assay, the presence of sesC was checked in 438 clinical staphylococcal isolates. Results showed that sesC is specifically present in all S...
September 2016: Infection, Genetics and Evolution
Seth A Hays, Andrea Ruiz, Thelma Bethea, Navid Khodaparast, Jason B Carmel, Robert L Rennaker, Michael P Kilgard
Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength...
July 2016: Neurobiology of Aging
Daniel R Hulsey, Seth A Hays, Navid Khodaparast, Andrea Ruiz, Priyanka Das, Robert L Rennaker, Michael P Kilgard
BACKGROUND: Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific reorganization of movement representations in the motor cortex. The mechanisms that underlie VNS-dependent enhancement of map plasticity are largely unknown. The cholinergic nucleus basalis (NB) is a critical substrate in cortical plasticity, and several studies suggest that VNS activates cholinergic circuitry. OBJECTIVE: We examined whether the NB is required for VNS-dependent enhancement of map plasticity in the motor cortex...
March 2016: Brain Stimulation
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