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https://www.readbyqxmd.com/read/27911313/challenges-in-screening-and-recruitment-for-a-neuroimaging-study-in-cognitively-impaired-geriatric-inpatients
#1
Ivayla Apostolova, Catharina Lange, Anna Roberts, Hans Joachim Igel, Anja Mäurer, Stephanie Liese, Melanie Estrella, Vikas Prasad, Elisabeth Stechl, Gernot Lämmler, Elisabeth Steinhagen-Thiessen, Ralph Buchert
BACKGROUND: Neuroimaging-based biomarkers have the potential to improve etiological diagnosis of cognitive impairment in elderly inpatients. However, there is a relative lack of studies on neuroimaging-based biomarkers in hospitalized geriatric patients, as the vast majority of neuroimaging studies in dementia have focused on memory clinic outpatients. An important aspect of study planning is a priori estimation of the rate of screen failures. OBJECTIVE: To report on the rate and causes of screen failures in a prospective study on the utility of neuroimaging (PET, MRI) for the etiological diagnosis of newly manifested cognitive impairment in acutely hospitalized geriatric patients...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909401/implicit-learning-in-transient-global-amnesia-and-the-role-of-stress
#2
Frauke Nees, Martin Griebe, Anne Ebert, Michaela Ruttorf, Benjamin Gerber, Oliver T Wolf, Lothar R Schad, Achim Gass, Kristina Szabo
Transient global amnesia (TGA) is a disorder with reversible anterograde disturbance of explicit memory, frequently preceded by an emotionally or physically stressful event. By using magnetic resonance imaging (MRI) following an episode of TGA, small hippocampal lesions have been observed. Hence it has been postulated that the disorder is caused by the stress-related transient inhibition of memory formation in the hippocampus. In experimental studies, stress has been shown to affect both explicit and implicit learning-the latter defined as learning and memory processes that lack conscious awareness of the information acquired...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27906953/what-s-tramadol-got-to-do-with-it-a-case-report-of-rebound-hypoglycemia-a-reappraisal-and-review-of-potential-mechanisms
#3
Charles A Odonkor, Akhil Chhatre
BACKGROUND: Tramadol has gained traction as an analgesic of choice among pain practicing physicians. However some concerns regarding a previously unlabeled adverse reaction - hypoglycemia - have cast it in a dim light. Prior reports have noted an associated risk of hospitalization for hypoglycemia after tramadol use, but whether tramadol is the main causal agent is poorly understood and the underlying mechanisms are not well delineated. We present a unique case of rebound hypoglycemia as a variation of the theme of tramadol's adverse effect profile in a patient with type 1 diabetes mellitus, and reappraise potential mechanisms underlying this underappreciated phenomenon...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27906742/is-preexisting-cervical-disk-degeneration-a-prognostic-factor-in-whiplash-associated-disorders
#4
Nam-Su Chung, Chang-Hoon Jeon, Yu-Sang Lee, Jang-Ho Park, Han-Dong Lee
STUDY DESIGN: This is a retrospective control study. OBJECTIVE: We aimed to determine whether preexisting cervical disk degeneration is a prognostic factor in Whiplash-associated disorder (WAD). SUMMARY OF BACKGROUND DATA: WAD is a common injury of traffic accident and has a broad range of prognoses. Although numerous studies have investigated prognostic factors in WAD, few have evaluated the effect of preexisting disk degeneration. MATERIALS AND METHODS: This study involved 45 consecutive patients with grade I or II WAD having advanced disk degeneration (at least 1 disk of Miyazaki grade≥III on magnetic resonance imaging) and a control cohort of 52 patients with no or mild disk degeneration (all disks having Miyazaki grades≤II)...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27904970/reliability-of-magnetic-resonance-imaging-versus-arthroscopy-for-the-diagnosis-and-classification-of-superior-glenoid-labrum-anterior-to-posterior-lesions
#5
Fatih Yıldız, Kerem Bilsel, Anıl Pulatkan, Gökçer Uzer, Ayşe Aralaşmak, Musa Atay
PURPOSE: The physical examination of the shoulder is usually not reliable for the true diagnosis of superior glenoid labrum anterior to posterior (SLAP) lesions. Magnetic resonance imaging (MRI) has been routinely used for the diagnosis. This prospective study investigates the radiological diagnosis of the SLAP lesions and compares accuracy of arthroscopic and MRI classifications. METHODS: One hundred thirty-two patients with positive physical examination signs using O'Brien, Yergason, resistance supination external rotation and Krank tests and MRI findings are included in the study...
November 30, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27904790/current-concepts-in-the-treatment-of-gross-patellofemoral-instability
#6
Grant Buchanan, LeeAnne Torres, Brian Czarkowski, Charles E Giangarra
: Patellofemoral instability is a painful and commonly recurring condition, which often must be managed surgically. Diagnosis can be aided by the use of a variety of physical exam signs, such as the Q angle, Beighton hypermobility score, glide test, J sign, patellar tilt test, and apprehension test. Imaging modalities including x-ray, CT, and MRI guide both diagnosis and management by revealing trochlear dysplasia, bony malalignment, and ligamentous injury that contribute to instability...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904756/ct-negative-mri-gre-positive-primary-motor-cortex-contusion-causing-isolated-foot-drop
#7
Alexander M Tucker, Tianyi Niu, Daniel T Nagasawa, Richard Everson, Shaina Sedighim, Manuel M Buitrago Blanco
BACKGROUND: Isolated acute foot drop due to traumatic brain injury is exceedingly rare and is often misdiagnosed during initial evaluation. Here, we present the case of a patient who presented with left foot drop after falling off a bicycle. CASE DESCRIPTION: The patient is a 55-year-old male who was mountain biking when he fell, hit his head, and lost consciousness. Neurologic examination of the left leg revealed foot drop, no sensory deficits, and 3+ reflexes at the knee and ankle with clonus...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27903541/lifelong-physical-activity-regardless-of-dose-is-not-associated-with-myocardial-fibrosis
#8
Shuaib M Abdullah, Kyler W Barkley, Paul S Bhella, Jeffrey L Hastings, Susan Matulevicius, Naoki Fujimoto, Shigeki Shibata, Graeme Carrick-Ranson, M Dean Palmer, Nainesh Gandhi, Laura F DeFina, Benjamin D Levine
BACKGROUND: Recent reports have suggested that long-term, intensive physical training may be associated with adverse cardiovascular effects, including the development of myocardial fibrosis. However, the dose-response association of different levels of lifelong physical activity on myocardial fibrosis has not been evaluated. METHODS AND RESULTS: Seniors free of major chronic illnesses were recruited from predefined populations based on the consistent documentation of stable physical activity over >25 years and were classified into 4 groups by the number of sessions/week of aerobic activities ≥30 minutes: sedentary (group 1), <2 sessions; casual (group 2), 2 to 3 sessions; committed (group 3), 4 to 5 sessions; and Masters athletes (group 4), 6 to 7 sessions plus regular competitions...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27903195/dosimetric-effects-of-onyx-embolization-on-gamma-knife-arteriovenous-malformation-dose-distributions
#9
David J Schlesinger, Håkan Nordström, Anders Lundin, Zhiyuan Xu, Jason P Sheehan
OBJECTIVE Patients with arteriovenous malformations (AVMs) treated with Gamma Knife radiosurgery (GKRS) subsequent to embolization suffer from elevated local failure rates and differences in adverse radiation effects. Onyx is a common embolic material for AVMs. Onyx is formulated with tantalum, a high atomic number (Z = 73) element that has been investigated as a source of dosimetric uncertainty contributing to the less favorable clinical results. However, prior studies have not modeled the complicated anatomical and beam geometries characteristic of GKRS...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27901096/image-based-in-vivo-assessment-of-targeting-accuracy-of-stereotactic-brain-surgery-in-experimental-rodent-models
#10
Janaki Raman Rangarajan, Greetje Vande Velde, Friso van Gent, Philippe De Vloo, Tom Dresselaers, Maarten Depypere, Kris van Kuyck, Bart Nuttin, Uwe Himmelreich, Frederik Maes
Stereotactic neurosurgery is used in pre-clinical research of neurological and psychiatric disorders in experimental rat and mouse models to engraft a needle or electrode at a pre-defined location in the brain. However, inaccurate targeting may confound the results of such experiments. In contrast to the clinical practice, inaccurate targeting in rodents remains usually unnoticed until assessed by ex vivo end-point histology. We here propose a workflow for in vivo assessment of stereotactic targeting accuracy in small animal studies based on multi-modal post-operative imaging...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900268/management-of-syndesmotic-injuries-what-is-the-evidence
#11
REVIEW
Marc Schnetzke, Sven Y Vetter, Nils Beisemann, Benedict Swartman, Paul A Grützner, Jochen Franke
Ankle fractures are accompanied by a syndesmotic injury in about 10% of operatively treated ankle fractures. Usually, the total rupture of the syndesmotic ligaments with an external rotation force is associated with a Weber type B or C fracture or a Maisonneuve fracture. The clinical assessment should consist of a comprehensive history including mechanism of injury followed by a specific physical examination. Radiographs, and if in doubt magnetic resonance imaging, are needed to ascertain the syndesmotic injury...
November 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/27900090/traumatic-rupture-of-solid-pseudopapillary-tumors-of-the-pancreas-in-children-a-case-report
#12
Semih Lütfi Mirapoğlu, Ibrahim Aydogdu, Zuhal Gucin, Temel Fatih Yilmaz, Tarik Umutoglu, Huseyin Kilincaslan
Solid pseudopapillary tumor (SPT) of the pancreas is a pathological entity rarely encountered in children. Despite its malignant characteristics, SPT has a favorable clinical prognosis. This tumor is more frequently observed in females and is commonly localized in the tail and body of the pancreas. This is the case report of a 9-year-old female patient who presented with severe abdominal pain of sudden onset and vomiting following blunt abdominal trauma. Upon physical examination, abdominal distension, tenderness and abdominal guarding were detected...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27898453/resolution-of-rectal-prolapse-by-vaginal-reconstruction
#13
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: Rectal prolapse is a disorder of the pelvic floor in which the layers of the rectal mucosa protrude outward through the anus. Surgical repair is the mainstay of treatment. Options include intra-abdominal procedures such as rectopexy and perineal procedures such as the Delorme and Altemeier perineal rectosigmoidectomy. Rectal and vaginal prolapse can often coexist. However, to our knowledge, there are no reported cases of rectal prolapse resolved by the repair of a compressive enterocele abutting the anterior rectal wall through a vaginal approach alone...
November 28, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27897412/systemic-inflammation-body-composition-and-physical-performance-in-old-community-dwellers
#14
Riccardo Calvani, Federico Marini, Matteo Cesari, Thomas W Buford, Todd M Manini, Marco Pahor, Christiaan Leeuwenburgh, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
BACKGROUND: Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related phenomena via multivariate modelling. METHODS: Thirty-five old adults (OAs) and 17 young adults (YAs) were enrolled. The volume of skeletal muscle, subcutaneous adipose tissue (SAT), and intermuscular adipose tissue (IMAT) of the thigh was quantified by three-dimensional magnetic resonance imaging...
August 8, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27897360/central-atrophy-early-in-multiple-sclerosis-third-ventricle-volumetry-versus-planimetry
#15
Theodor Lutz, Barbara Bellenberg, Ruth Schneider, Florian Weiler, Odo Köster, Carsten Lukas
BACKGROUND AND PURPOSE: Cerebral atrophy has been suggested to be a reliable magnetic resonance imaging (MRI) predictor of subsequent disability in all stages of multiple sclerosis (MS). However, no accepted methodology for routine clinical use exists to date. We sought an easy to apply and fast technique to evaluate cerebral ventricular volume in patients with MS with similar accuracy as a semiautomatic volumetric method. METHODS: The study included 104 patients, 61 diagnosed with MS and 43 with clinically isolated syndrome...
November 28, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27897245/engineering-genetically-encoded-mineralization-and-magnetism-via-directed-evolution
#16
Xueliang Liu, Paola A Lopez, Tobias W Giessen, Michael Giles, Jeffrey C Way, Pamela A Silver
Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing and control. Via directed evolution of the natural iron-sequestering ferritin protein, we discovered key mutations that lead to significantly enhanced cellular magnetism, resulting in increased physical attraction of ferritin-expressing cells to magnets and increased contrast for cellular magnetic resonance imaging (MRI). The magnetic mutants further demonstrate increased iron biomineralization measured by a novel fluorescent genetic sensor for intracellular free iron...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895770/classical-intracranial-chondrosarcoma-a-case-report
#17
Jingyang Chi, Mingchao Zhang, Jianmin Kang
Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had lasted for 2 years. Physical and neurological examinations were normal. Radiography of the skull identified an opaque lesion in the left frontal region of the brain. Cranial computed tomography and magnetic resonance imaging revealed a lesion with calcification and homogenous contrast enhancement in the left frontal region...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894374/autologous-intratympanic-blood-patch-for-presumed-perilymphatic-fistulas
#18
P K Foster
OBJECTIVE: To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections. METHOD: A review was conducted of patients' history, physical and audiometric data, before and after treatment by intratympanic blood injections performed from 2009 to 2015. RESULTS: Twelve ears were identified, with trauma associated with air travel, water sports or nose blowing. Ten of these cases had hearing loss, six had vestibular symptoms...
November 29, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27891281/septooptic-dysplasia-with-an-associated-arachnoid-cyst
#19
Skyler V McLaurin-Jiang, Julie K Wood, David F Crudo
A 4-week-old male infant presented with hypothermia, hypoglycemia, and hyperbilirubinemia. His medical history was remarkable for hydrocephalus secondary to an arachnoid cyst, intermittent hypoglycemia, hypothermia, and poor feeding requiring nasogastric tube for nutrition. Physical exam revealed retrognathia, mild hypotonia, micropenis, and clinodactyly. Ophthalmologic exam demonstrated bilateral optic nerve hypoplasia (ONH). Laboratory data confirmed inadequate cortisol and growth hormone response to hypoglycemia, a low thyroxine level, and direct hyperbilirubinemia...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27890757/percutaneous-endoscopic-removal-of-a-lumbar-epidural-angiolipoma-via-interlaminar-approach-a-technical-report
#20
Guang-Yu Ying, Ying Yao, Fang Shen, Yu-Cheng Ren, Chien-Min Chen, Yong-Jian Zhu
BACKGROUND: Percutaneous endoscopic technique has been routinely used in the treatment of disk herniation while there are few reports on its application in the management of intraspinal tumors. We presented here the first case report of lumbar epidural angiolipoma that was totally removed by percutaneous endoscopy. CASE DESCRIPTION: A 63-year-old man presented with 4-month history of progressively worsening low back pain was admitted to our hospital. No abnormal neurological finding was noticed on physical examination and magnetic resonance imaging demonstrated a dorsally located L2-L3 epidural lesion, suggestive of a non-infiltrating angiolipoma...
November 24, 2016: World Neurosurgery
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