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https://www.readbyqxmd.com/read/28103626/nonalcoholic-fatty-liver-disease-in-adolescents-and-young-adults-the-next-frontier-in-the-epidemic
#1
REVIEW
Iliana Doycheva, Kymberly D Watt, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is a significant health burden in adolescents and young adults (AYAs) with substantial rise in prevalence over the last decades. This parallels high rates of obesity and metabolic syndrome in this age group, with unhealthy lifestyle also playing an independent role. Genetic factors, gender, and ethnicity should be considered in a risk stratification model. NAFLD and nonalcoholic steatohepatitis (NASH) in AYAs often go unrecognized and if untreated, can progress eventually to cirrhosis requiring liver transplantation before the age of 40...
January 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28103542/interactive-exploration-of-3d-scanned-baggage
#2
Michael Traore, Christophe Hurter
An interactive visualization system can support volumetric data exploration in airport security screenings by addressing the challenges unique to the baggage inspection. The proposed system includes a set of interaction techniques that combine the direct manipulation of voxels and their interactive visualization. The system's final tools and GUI design incorporate feedback from airport personnel and were validated by real-world users in terms of effectiveness and ease of use.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103531/characterization-of-transcriptome-and-identification-of-biomineralization-genes-in-winged-pearl-oyster-pteria-penguin-mantle-tissue
#3
Haimei Li, Baosuo Liu, Guiju Huang, Sigang Fan, Bo Zhang, Jiaqi Su, Dahui Yu
The winged pearl oyster Pteria penguin is a commercially important marine pearl oyster species, with pearls that are quite different from those of other pearl oysters. Among such species, mantle tissue is the main organ responsible for shell and pearl formation, a biomineralization process that is regulated by a series of genes, most of which remain unknown. In this study, we sequenced and characterized the transcriptome of P. penguin mantle tissue using the HiSeq 2000 sequencing platform. A total of 93,204 unique transcripts were assembled from 51,580,076 quality reads, with a mean length of 608bp, and 40,974 unigenes were annotated...
January 8, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#4
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28103496/toddlers-action-prediction-statistical-learning-of-continuous-action-sequences
#5
Claire D Monroy, Sarah A Gerson, Sabine Hunnius
The current eye-tracking study investigated whether toddlers use statistical information to make anticipatory eye movements while observing continuous action sequences. In two conditions, 19-month-old participants watched either a person performing an action sequence (Agent condition) or a self-propelled visual event sequence (Ghost condition). Both sequences featured a statistical structure in which certain action pairs occurred with deterministic transitional probabilities. Toddlers learned the transitional probabilities between the action steps of the deterministic action pairs and made predictive fixations to the location of the next action in the Agent condition but not in the Ghost condition...
January 16, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28103306/a-superoxide-dismutase-capable-of-functioning-with-iron-or-manganese-promotes-the-resistance-of-staphylococcus-aureus-to-calprotectin-and-nutritional-immunity
#6
Yuritzi M Garcia, Anna Barwinska-Sendra, Emma Tarrant, Eric P Skaar, Kevin J Waldron, Thomas E Kehl-Fie
Staphylococcus aureus is a devastating mammalian pathogen for which the development of new therapeutic approaches is urgently needed due to the prevalence of antibiotic resistance. During infection pathogens must overcome the dual threats of host-imposed manganese starvation, termed nutritional immunity, and the oxidative burst of immune cells. These defenses function synergistically, as host-imposed manganese starvation reduces activity of the manganese-dependent enzyme superoxide dismutase (SOD). S. aureus expresses two SODs, denoted SodA and SodM...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103299/walking-through-apertures-in-individuals-with-stroke
#7
Daisuke Muroi, Yasuhiro Hiroi, Teruaki Koshiba, Yohei Suzuki, Masahiro Kawaki, Takahiro Higuchi
OBJECTIVE: Walking through a narrow aperture requires unique postural configurations, i.e., body rotation in the yaw dimension. Stroke individuals may have difficulty performing the body rotations due to motor paralysis on one side of their body. The present study was therefore designed to investigate how successfully such individuals walk through apertures and how they perform body rotation behavior. METHOD: Stroke fallers (n = 10), stroke non-fallers (n = 13), and healthy controls (n = 23) participated...
2017: PloS One
https://www.readbyqxmd.com/read/28103292/muscle-reactive-oxygen-species-ros-contribute-to-post-incisional-guarding-via-the-trpa1-receptor
#8
Daisuke Sugiyama, Sinyoung Kang, Timothy J Brennan
BACKGROUND: Deep tissues and their afferents have unique responses to various stimuli and respond to injury distinctively. However, the types of receptors and endogenous ligands that have a key role in pain after deep tissue incision are unknown. TRPA1 has been shown to mediate pain-related responses in inflammation- and nerve injury-induced pain models. We hypothesized that TRPA1 has an important role in pain behaviors after deep tissue incision. METHODS: The effect of various doses of intraperitoneal (i...
2017: PloS One
https://www.readbyqxmd.com/read/28103279/aristaless-related-homeobox-arx-interacts-with-%C3%AE-catenin-bcl9-and-p300-to-regulate-canonical-wnt-signaling
#9
Il-Taeg Cho, Youngshin Lim, Jeffrey A Golden, Ginam Cho
Mutations in the Aristaless Related Homeobox (ARX) gene are associated with a spectrum of structural (lissencephaly) and functional (epilepsy and intellectual disabilities) neurodevelopmental disorders. How mutations in this single transcription factor can result in such a broad range of phenotypes remains poorly understood. We hypothesized that ARX functions through distinct interactions with specific transcription factors/cofactors to regulate unique target genes in different cell types. To identify ARX interacting proteins, we performed an unbiased proteomics screen and identified several components of the Wnt/β-catenin signaling pathway, including β-catenin (CTNNB1), B-cell CLL/lymphoma 9 (BCL9) and leucine rich repeat flightless interacting protein 2 (LRRFIP2), in cortical progenitor cells...
2017: PloS One
https://www.readbyqxmd.com/read/28103238/weak-genetic-structure-in-northern-african-dromedary-camels-reflects-their-unique-evolutionary-history
#10
Youcef Amine Cherifi, Suheil Bechir Semir Gaouar, Rosangela Guastamacchia, Khalid Ahmed El-Bahrawy, Asmaa Mohammed Aly Abushady, Abdoallah Aboelnasr Sharaf, Derradji Harek, Giovanni Michele Lacalandra, Nadhira Saïdi-Mehtar, Elena Ciani
Knowledge on genetic diversity and structure of camel populations is fundamental for sustainable herd management and breeding program implementation in this species. Here we characterized a total of 331 camels from Northern Africa, representative of six populations and thirteen Algerian and Egyptian geographic regions, using 20 STR markers. The nineteen polymorphic loci displayed an average of 9.79 ± 5.31 alleles, ranging from 2 (CVRL8) to 24 (CVRL1D). Average He was 0.647 ± 0.173. Eleven loci deviated significantly from Hardy-Weinberg proportions (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28103228/human-specific-cortical-synaptic-connections-and-their-plasticity-is-that-what-makes-us-human
#11
Joana Lourenço, Alberto Bacci
One outstanding difference between Homo sapiens and other mammals is the ability to perform highly complex cognitive tasks and behaviors, such as language, abstract thinking, and cultural diversity. How is this accomplished? According to one prominent theory, cognitive complexity is proportional to the repetition of specific computational modules over a large surface expansion of the cerebral cortex (neocortex). However, the human neocortex was shown to also possess unique features at the cellular and synaptic levels, raising the possibility that expanding the computational module is not the only mechanism underlying complex thinking...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28103139/endotoxin-neutralization-by-an-o-antigen-specific-monoclonal-antibody-a-potential-novel-therapeutic-approach-against-klebsiella-pneumoniaest258
#12
Valéria Szijártó, Luis M Guachalla, Katharina Hartl, Cecília Varga, Adriana Badarau, Irina Mirkina, Zehra C Visram, Lukas Stulik, Christine A Power, Eszter Nagy, Gábor Nagy
Klebsiella pneumoniae ST258 is a globally distributed multi-drug resistant pathogen responsible for severe invasive infections. In this study, the different virulence potential of K. pneumoniae ST258 isolates in endotoxin susceptible versus resistant animal models was shown. Furthermore, ST258 clinical isolates were found highly sensitive to the bactericidal effect of naive animal and human serum. These observations imply that LPS, released from the rapidly lysed bacteria, may contribute to the high mortality associated with ST258 bacteremia cases...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28103108/secondary-school-students-knowledge-and-opinions-on-astrobiology-topics-and-related-social-issues
#13
Raquel Oreiro, Jordi Solbes
Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that consisted of 10 open questions on the topic of astrobiology...
January 2017: Astrobiology
https://www.readbyqxmd.com/read/28103105/evolution-of-earth-like-extrasolar-planetary-atmospheres-assessing-the-atmospheres-and-biospheres-of-early-earth-analog-planets-with-a-coupled-atmosphere-biogeochemical-model
#14
S Gebauer, J L Grenfell, J W Stock, R Lehmann, M Godolt, P von Paris, H Rauer
Understanding the evolution of Earth and potentially habitable Earth-like worlds is essential to fathom our origin in the Universe. The search for Earth-like planets in the habitable zone and investigation of their atmospheres with climate and photochemical models is a central focus in exoplanetary science. Taking the evolution of Earth as a reference for Earth-like planets, a central scientific goal is to understand what the interactions were between atmosphere, geology, and biology on early Earth. The Great Oxidation Event in Earth's history was certainly caused by their interplay, but the origin and controlling processes of this occurrence are not well understood, the study of which will require interdisciplinary, coupled models...
January 2017: Astrobiology
https://www.readbyqxmd.com/read/28103104/characterization-and-molecular-subtyping-of-shiga-toxin-producing-escherichia-coli-strains-in-butcher-shops
#15
Victoria Brusa, Magdalena Costa, Alejandra Londero, Gerardo A Leotta, Lucía Galli
Shiga toxin-producing Escherichia coli (STEC) are important emerging foodborne human pathogens. Ruminants are the main animal reservoir of STEC currently known, and meat can become contaminated at different stages of the production chain. The aim of this work was to subtype and establish the epidemiological relatedness of non-O157 STEC strains isolated from ground beef and the environment in butcher shops before (evaluation stage, 2010-2011 period) and after (verification stage, 2013) implementing improvement actions...
January 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28103080/organization-of-bbmri-pl-the-polish-biobanking-network
#16
Małgorzata Witoń, Dominik Strapagiel, Joanna Gleńska-Olender, Anna Chróścicka, Katarzyna Ferdyn, Jarosław Skokowski, Leszek Kalinowski, Jakub Pawlikowski, Błażej Marciniak, Markus Pasterk, Agnieszka Matera-Witkiewicz, Łukasz Kozera
In Poland storage of human biological samples takes place at most universities and scientific institutions conducting research projects in the field of biomedicine. The First International Biobanking Conference organized by the Ministry of Science and Higher Education in 2014 shed a light on the situation of Polish biobanking infrastructures. The country has around 40 large biorepositories, which store unique biological material such as whole brains, muscle fibers from patients with rare diseases, as well as thousands of samples from patients with lifestyle diseases...
January 19, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28103072/community-health-records-establishing-a-systematic-approach-to-improving-social-and-physical-determinants-of-health
#17
Deryk Van Brunt
To systematically improve population health in the United States, community health records (CHRs) must be defined, developed, and implemented. Like electronic and personal health records, CHRs have both unique and overlapping information. CHRs contain data about communities, including the social, physical, and lifestyle determinants of health. These records will serve to complement electronic and personal health records to provide a more complete view of population health, allowing stakeholders to target community health and quality-of-life interventions in a data-driven and evidence-based manner, establishing the basis from which organizations can develop a systematic approach to improving community health...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28103063/delivering-on-the-promise-of-smoke-free-public-housing
#18
Douglas E Levy, Inez F Adams, Gary Adamkiewicz
On November 30, 2016, the US Department of Housing and Urban Development (HUD) published a final rule mandating that public housing authorities it supports prohibit all smoking on their residential premises, including within residents' apartments. The primary rationale for this action was to protect nonsmoking residents from the harms of tobacco smoke exposure. Although the harms of secondhand smoke are clear and the potential for reducing nonsmoking residents' exposure is real, it will be no simple matter to successfully implement the policy requirements set down by HUD...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28103020/diazatetracenes-derived-from-the-benzannulation-of-acetylenes-electronic-tuning-via-substituent-effects-and-external-stimuli
#19
Dan Lehnherr, Joaquin M Alzola, Catherine R Mulzer, William R Dichtel
Functionalized diazatetracenes are prepared using a new two-step sequence. The use of a dichlorobenzaldehyde in a Cu-catalyzed benzannulation of acetylenes provides functionalized dichloronaphthalenes that afford diazatetracenes using Buchwald-Hartwig aminations. This approach provides unique substitution patterns and rapid access to covalently linked dimeric diazatetracenes. Their electronic properties are characterized by UV-vis absorption/emission and cyclic voltammetry, revealing strong effects from both external stimuli by acid and internal substituent effects...
January 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28103019/highly-water-stable-novel-lanthanide-wheel-cluster-organic-frameworks-featuring-coexistence-of-hydrophilic-cage-like-chambers-and-hydrophobic-nanosized-channels
#20
Yuan-Yuan Zhou, Yang Shi, Bing Geng, Qi-Bing Bo
In attempts to investigate the potential luminescent sensing materials for sensitive detection of environmental pollutants, a new family of lanthanide wheel cluster organic frameworks (Ln-WCOFs) UJN-Ln4 has been constructed by employing one of the cycloalkane dicarboxylic acid derivatives. Adopting different conformations, the ligand links Ln4 second building units (SBUs) and Ln24 tertiary building unit (TBUs) to form a unique wheel cluster layer-pillared 3D framework featuring the coexistence of hydrophobic nanosized channels and trigonal anti-prism arrays with hydrophilic cage-like chambers...
January 19, 2017: ACS Applied Materials & Interfaces
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