Luka Vlahovic, Jamie McDonald, Jessica Hinman, Anna Tomczak, Christopher Lock, Chella A Palmer, Lawrence J Cook, Michael R Yeaman, Melinda K Burnett, Gayle K Deutsch, Lorene M Nelson, May H Han
BACKGROUND AND OBJECTIVES: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic CNS demyelinating autoimmune disorder targeting the astrocyte antigen aquaporin-4 (AQP4), typically presenting with optic neuritis, transverse myelitis, and brain syndromes. Cognitive dysfunction (CD) in NMOSD is under-recognized and poorly understood. The purpose of this study was to evaluate the prevalence and clinical variables associated with CD in NMOSD. METHODS: This observational retrospective study with longitudinal follow-up describes a clinical cohort seen in the Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD...
January 9, 2024: Neurology