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Acinetobacter baumanii resistent

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https://www.readbyqxmd.com/read/29075483/extended-spectrum-and-metalo-beta-lactamase-producing-airborne-pseudomonas-aeruginosa-and-acinetobacter-baumanii-in-restricted-settings-of-a-referral-hospital-a-neglected-condition
#1
Fithamlak Bisetegen Solomon, Fiseha Wadilo, Efrata Girma Tufa, Meseret Mitiku
BACKGROUND: Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment. The aim of this study was to determine the prevalence and pattern of antibiotic resistance, extended spectrum and metallo beta-lactamase producing P. aeruginosa and A. baumannii isolates from restricted settings of indoor air hospital environment. METHODS: A hospital-based cross-sectional study was conducted in Wolaita Sodo University Teaching and referral Hospital, Ethiopia from December 1/2015 to April 30/2015...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29063446/extensive-colonization-with-carbapenemase-producing-microorganisms-in-romanian-burn-patients-infectious-consequences-from-the-colectiv-fire-disaster
#2
L E Pirii, A W Friedrich, J W A Rossen, W Vogels, G I J M Beerthuizen, M K Nieuwenhuis, A M D Kooistra-Smid, E Bathoorn
Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control...
October 23, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29062249/a-retrospective-evaluation-of-blood-cultures-in-a-pediatric-intensive-care-unit-a-three-year-evaluation
#3
Ayşe Betül Ergül, Halit Işık, Yasemin Ay Altıntop, Yasemin Altuner Torun
AIM: In this study, it was aimed to retrospectively assess the frequency and antibiotic resistance of microorganisms isolated from blood cultures of patients in a pediatric intensive care unit. MATERIAL AND METHODS: The study was conducted on blood culture tests obtained from patients in a pediatric intensive care unit and sent to a microbiology laboratory between 2013 and 2016. The species and antibiotic susceptibilities were assessed in microorganisms isolated from the blood cultures...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28803189/efficacy-of-radiant-catalytic-ionization-to-reduce-bacterial-populations-in-air-and-on-different-surfaces
#4
Krzysztof Skowron, Katarzyna Grudlewska, Joanna Kwiecińska-Piróg, Grzegorz Gryń, Mścisław Śrutek, Eugenia Gospodarek-Komkowska
Air contamination by biological agents is often observed in medical or veterinary facilities and industrial plants. Bioaerosols may sediment and pose the surface contamination. Microorganisms present on them may become a source of infections among humans and food contamination. This study determined the use of oxidative gases, including ozone and peroxide, generated by the Radiant Catalytic Ionization (RCI) cell for the inactivation of Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella Enteritidis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus epidermidis, Bacillus subtilis, Clostridium sporogenes, Candida albicans, Aspergillus niger and Penicillium chrysogenumon in air and on different surfaces...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28724383/molecular-characterization-and-genetic-relatedness-of-clinically-acinetobacter-baumanii-isolates-conferring-increased-resistance-to-the-first-and-second-generations-of-tetracyclines-in-iran
#5
Zahra Meshkat, Himen Salimizand, Yousef Amini, Mostafa Khakshoor, Davoud Mansouri, Hadi Farsiani, Kiarash Ghazvini, Adel Najafi
BACKGROUND: The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. By comparing genetic characteristics and relatedness of A. baumannii isolates, we are able to determine the transition dynamics of outbreak isolates. METHODS: A total of 72 non-duplicate isolates of A...
July 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28535606/isolation-purification-and-characterization-of-five-active-diketopiperazine-derivatives-from-endophytic-streptomyces-suk-25-with-antimicrobial-and-cytotoxic-activities
#6
Muhanna Alshaibani, Noraziah Zin, Juriyati Jalil, Nik Sidik, Siti Junaidah Ahmad, Nurkhalida Kamal, Ruangelie Edrada-Ebel
In our search for new sources of bioactive secondary metabolites from Streptomyces sp., the ethyl acetate extracts from endophytic Streptomyces SUK 25 afforded five active diketopiperazine (DKP) compounds. The aim of this study was to characterize the bioactive compounds isolated from endophytic Streptomyces SUK 25 and evaluate their bioactivity against multiple drug resistance (MDR) bacteria such as Enterococcus raffinosus, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter spp...
July 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28465626/synthesis-and-biological-evaluation-of-indole-core-based-derivatives-with-potent-antibacterial-activity-against-resistant-bacterial-pathogens
#7
Wei Hong, Jingyang Li, Zhe Chang, Xiaoli Tan, Hao Yang, Yifan Ouyang, Yanhui Yang, Sargit Kaur, Ian C Paterson, Yun Fong Ngeow, Hao Wang
The emergence of drug resistance in bacterial pathogens is a growing clinical problem that poses difficult challenges in patient management. To exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. Here we describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by molecular modeling to be potential glycosyltransferase inhibitors. Twenty of these derivatives were found to show in vitro inhibition of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus...
July 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28462048/pitfalls-associated-with-evaluating-enzymatic-quorum-quenching-activity-the-case-of-moml-and-its-effect-on-pseudomonas-aeruginosa-and-acinetobacter-baumannii-biofilms
#8
Yunhui Zhang, Gilles Brackman, Tom Coenye
BACKGROUND: The enzymatic degradation of quorums sensing (QS) molecules (called quorum quenching, QQ) has been considered as a promising anti-virulence therapy to treat biofilm-related infections and combat antibiotic resistance. The recently-discovered QQ enzyme MomL has been reported to efficiently degrade different N-acyl homoserine lactones (AHLs) of various Gram-negative pathogens. Here we investigated the effect of MomL on biofilms formed by two important nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii...
2017: PeerJ
https://www.readbyqxmd.com/read/28434558/resistance-profiles-and-risk-factors-of-resistant-microorganisms-in-bacteraemia-of-abdominal-origin
#9
J Martín Jaramago, R Armero Ibáñez, J J Camarena Miñana, M Morales Suárez-Varela
OBJECTIVE: The presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. The objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. MATERIAL AND METHODS: A clinical, observational, epidemiological, retrospective cohort study was conducted with all the adult patients admitted to a university hospital from 2011-2013...
April 20, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28410511/evaluation-of-intraventricular-colistin-utilization-a-case-series
#10
Brian Gilbert, Christopher Morrison
PURPOSE: Multi-drug resistant organisms (MDROs) are an increasing concern in health systems. Pathogens such as Pseudomonas aeruginosa, Acinetobacter baumanii, and carbapenamase-producing Enterobacteriaceae hold highest mortality rates especially when the central nervous system is involved. When MDROs are cultured treatment options are limited and reliance on medications such as colistin is becoming more prevalent. Penetration of these therapies into the central nervous system is concerning therefore local administration is a potential concomitant therapy...
April 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28400958/in-vitro-evaluation-of-the-susceptibility-of-acinetobacter-baumannii-isolates-to-antiseptics-and-disinfectants-comparison-between-clinical-and-environmental-isolates
#11
Sanae Lanjri, Jean Uwingabiye, Mohammed Frikh, Lina Abdellatifi, Jalal Kasouati, Adil Maleb, Abdelouahed Bait, Abdelhay Lemnouer, Mostafa Elouennass
BACKGROUND: This study aims to assess the susceptibility of Acinetobacter baumannii isolates to the antiseptics and disinfectants commonly used, and to the non-approved product. METHODS: This is a prospective study carried out from February to August 2015, in the Bacteriology department of Mohammed V Military Teaching hospital of Rabat on A.baumannii isolates collected from colonized and/or infected patients and environmental samples. The antiseptics and disinfectants susceptibility testing was assessed using the micromethod validated in our department...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28384861/molecular-characterization-of-multidrug-resistant-strains-of-acinetobacter-baumannii-isolated-from-intensive-care-units-in-west-of-iran
#12
Parviz Mohajeri, Abbas Farahani, Rasa Sheini Mehrabzadeh
INTRODUCTION: According to the results of various studies using phenotypic methods, the prevalence of Multidrug Resistant (MDR) Acinetobacter baumannii (A. baumannii) isolates has been increasing worldwide. Pulsed-Field Gel Electrophoresis (PFGE) technique is known as the gold standard method to determine clonal characterization of bacterial species, especially A. baumannii. AIM: To determine the clonal relatedness and investigate the prevalence of integron classes 1 and 2 and genes encoding OXA-23 and 24 in A...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28328294/microbiological-characteristics-and-clinical-outcomes-of-acinetobacter-spp-endophthalmitis-with-the-first-reported-case-of-acinetobacter-haemolyticus-endophthalmitis
#13
Mahima Jhingan, Divya Balakrishnan, Padmaja Kumari Rani, Mudit Tyagi, Joveeta Joseph
AIM: To present the microbiological details and clinical outcomes of Acinetobacter spp. endophthalmitis with the first reported case of A. haemolyticus. METHODS: A retrospective study of microbiologically proven Acinetobacter spp. endophthalmitis was carried out from 2010 to 2015. The data collected included age, type of endophthalmitis, best-corrected visual acuity (BCVA), species involved, and antibiotic susceptibility pattern. The primary outcomes measured were anatomical outcomes in terms of globe integrity and functional outcome as BCVA at last follow-up...
March 22, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28237694/analysis-of-clinical-and-microbiological-data-on-acinetobacter-baumannii-strains-assist-the-preauthorization-of-antibiotics-at-the-patient-level-for-an-effective-antibiotic-stewardship-program
#14
Khine Swe Swe-Han, Koleka P Mlisana, Manormoney Pillay
Drug resistant Acinetobacter baumannii (A. baumannii) poses serious treatment challenges and is on the rise worldwide. The Infectious Diseases Society of America/Society for Healthcare Epidemiology of America recommends preauthorization of antibiotics to ensure successful antibiotic stewardship programs (ASWPs). This study estimates and analyzes the microbiological and clinical characteristics of A. baumanii strains with differentiating criteria for sepsis versus colonization, in order to support preauthorization and assist ASWPs at the patient level...
February 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28153582/changing-trends-in-antimicrobial-susceptibility-pattern-of-bacterial-isolates-in-a-burn-unit
#15
Narendra Pal Singh, Mayuri Rani, Kavita Gupta, Tanu Sagar, Iqbal Rajinder Kaur
INTRODUCTION: Emerging antimicrobial resistance in nosocomial bacterial isolates, limits the available treatment options for burn wound infections, among them multi-drug resistant Gram negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are major contributors to the increase in morbidity and mortality rates. MATERIAL AND METHODS: A retrospective cross-sectional study was done in the Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi...
August 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28149487/clinical-response-and-outcome-of-pneumonia-due-to-multi-drug-resistant-acinetobacter-baumannii-in-critically-ill-patients
#16
Lida Shojaei, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Mahsa Doomanlou, Alireza Abdollahi, Mohammad Mehdi Feizabadi, Hossein Khalili
BACKGROUND AND OBJECTIVES: The frequency of multi-drug resistant Acinetobacter spp. infections is increasing in Iran. Considering availability of limited therapeutic options, clinical response and outcome of ventilator-associated pneumonia due to multi-drug resistant A.baumannii were evaluated in critically ill patients. MATERIALS AND METHODS: In this prospective study, 29 patients with carbapenem resistance A. baumannii ventilator-associated pneumonia were enrolled...
October 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28089718/cathelicidin-antimicrobial-peptide-from-alligator-mississippiensis-has-antibacterial-activity-against-multi-drug-resistant-acinetobacter-baumanii-and-klebsiella-pneumoniae
#17
Stephanie M Barksdale, Evelyn J Hrifko, Monique L van Hoek
Alligator mississippiensis (American alligator), a member of order Crocodilia, lives in bacteria-laden environments but is not often known to succumb to bacterial infections. Their serum has been shown to have antibacterial activity beyond that of human serum, and it is believed that this activity is partially due to cationic antimicrobial peptides (CAMPs). CAMPs are produced by many organisms as part of the innate immune system. CAMPs are attractive possible therapies against multi-drug resistant bacteria, such as those found in biofilm-infected war wounds, because they seldom cause genetic resistance in bacteria and are effective against antibiotic resistant bacteria...
January 13, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28035408/identification-of-antibiotic-resistance-genes-in-the-multidrug-resistant-acinetobacter-baumannii-strain-mdr-shh02-using-whole-genome-sequencing
#18
Hualiang Wang, Jinghua Wang, Peijuan Yu, Ping Ge, Yanqun Jiang, Rong Xu, Rong Chen, Xuejie Liu
This study aimed to investigate antibiotic resistance genes in the multidrug-resistant (MDR) Acinetobacter baumannii (A. baumanii) strain, MDR-SHH02, using whole‑genome sequencing (WGS). The antibiotic resistance of MDR-SHH02 isolated from a patient with breast cancer to 19 types of antibiotics was determined using the Kirby‑Bauer method. WGS of MDR-SHH02 was then performed. Following quality control and transcriptome assembly, functional annotation of genes was conducted, and the phylogenetic tree of MDR-SHH02, along with another 5 A...
February 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27902392/microbiological-sentinel-events-at-a-neurological-hospital-a-retrospective-cohort-study
#19
Annalia Asti, Elio Marmondi, Carmine Tinelli, Marta Corbella, Annalisa De Silvestri, Gaetano Bernardi, Franco Andreini, Anna Preti, Monica Bricchi
The purpose of this study is to describe the epidemiological surveillance of microbiological sentinel events (SEs) carried out between 2012 and 2014 at the Neurological Hospital Carlo Besta, Milano, Italy. The setting is inpatient care with multidrug-resistant infections. The aim of the procedure is to formalize the management mode, reporting and transmission of SEs. Categorical variables were described by counts and percentages, as mean and sd or median and interquartile range. The incidence rates of SE were calculated per 1000 patient-days and for 100 admissions using Poisson distribution...
December 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27766913/patient-specific-risk-stratification-for-antimicrobial-resistance-and-possible-treatment-strategies-in-gram-negative-bacterial-infections
#20
REVIEW
Matteo Bassetti, Alessia Carnelutti, Maddalena Peghin
The isolation of multi-drug-resistant gram-negative (MDRGN) pathogens has progressively increased worldwide and has been associated with important delays in the prescription of an adequate antibiotic treatment, resulting in increased mortality rates. Patient's stratification for MDRGN infections to optimize the prescription of an adequate empiric antimicrobial regimen is crucial. Areas covered: This article covers MDRGN epidemiology, with a specific focus on risk factors for harbouring infections sustained by extended-spectrum-Beta-lactamase (ESBL), carbapenem resistant Enterobacteriacae (CRE), MDR Pseudomonas aeruginosa and MDR Acinetobacter baumanii...
January 2017: Expert Review of Anti-infective Therapy
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