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Acinetobacter baumanii resistent

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https://www.readbyqxmd.com/read/29662260/characterization-of-multidrug-resistant-acinetobacter-ssp-strains-isolated-from-medical-intensive-care-units-in-cali-colombia
#1
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29643650/minocycline-the-second-important-antimicrobial-in-multidrug-resistant-acinetobacter-baumanii-infections
#2
Abhijit S Nair
No abstract text is available yet for this article.
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29589993/incidence-of-multidrug-resistant-organism-among-children-admitted-to-pediatric-intensive-care-unit-in-a-developing-country
#3
Ahmed El-Nawawy, Galal A Ashraf, Manal A M Antonios, Marwa A Meheissen, Marwa M R El-Alfy
AIM: Multidrug-resistant infections are an increasingly common condition particularly in critical care units. This study aimed to determine the incidence and types of resistant bacteria acquired in a pediatric intensive care unit (PICU) of a university hospital. SUBJECT AND METHODS: A prospective study was conducted during the year 2016. All children aged below 16 years were studied for infection development and pattern of susceptibility to various groups of antibiotics...
March 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29582720/multidrug-resistant-acinetobacter-baumanii-a-15-year-trend-analysis
#4
Dana L Russell, Daniel Z Uslan, Zachary A Rubin, Tristan R Grogan, Elise M Martin
From 2000 to 2009, rates of multidrug-resistant Acinetobacter baumanii increased 10-fold to 0.2 per 1,000 patient days. From 2010 to 2015, however, rates markedly declined and have stayed below 0.05 per 1,000 patient days. Herein, we present a 15-year trend analysis and discuss interventions that may have led to the decline.Infect Control Hosp Epidemiol 2018;1-4.
March 27, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29461939/antibacterial-properties-of-four-novel-hit-compounds-from-a-methicillin-resistant-staphylococcus-aureus-caenorhabditis-elegans-high-throughput-screen
#5
Nagendran Tharmalingam, Rajmohan Rajmuthiah, Wooseong Kim, Beth Burgwyn Fuchs, Elamparithi Jeyamani, Michael J Kelso, Eleftherios Mylonakis
There is an urgent need for the discovery of effective new antimicrobial agents to combat the rise of bacterial drug resistance. High-throughput screening (HTS) in whole-animal infection models is a powerful tool for identifying compounds that show antibacterial activity and low host toxicity. In this report, we characterize the activities of four novel antistaphylococcal compounds identified from an HTS campaign conducted using Caenorhabditis elegans nematodes infected with methicillin-resistant Staphylococcus aureus (MRSA)...
February 20, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29396362/discovery-of-2-aminothiazolyl-berberine-derivatives-as-effectively-antibacterial-agents-toward-clinically-drug-resistant-gram-negative-acinetobacter-baumanii
#6
Wei-Wei Gao, Lavanya Gopala, Rammohan R Yadav Bheemanaboina, Guo-Biao Zhang, Shuo Li, Cheng-He Zhou
Aminothiazolyl berberine derivatives as potentially antimicrobial agents were designed and synthesized in an effort to overcome drug resistance. The antimicrobial assay revealed that some target compounds exhibited significantly inhibitory efficiencies toward bacteria and fungi including drug-resistant pathogens, and the aminothiazole and Schiff base moieties were helpful structural fragments for aqueous solubility and antibacterial activity. Especially, aminothiazolyl 9-hexyl berberine 9c and 2,4-dichlorobenzyl derivative 18a exhibited good activities (MIC = 2 nmol/mL) against clinically drug-resistant Gram-negative Acinetobacter baumanii with low cytotoxicity to hepatocyte LO2 cells, rapidly bactericidal effects and quite slow development of bacterial resistance toward A...
January 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29366864/green-synthesized-silver-nanoparticles-by-marine-endophytic-fungus-penicillium-polonicum-and-its-antibacterial-efficacy-against-biofilm-forming-multidrug-resistant-acinetobacter-baumanii
#7
Sahadevan Neethu, Sebastian Jose Midhun, E K Radhakrishnan, Mathew Jyothis
Acinetobacter baumanii, a gram-negative, non-motile, encapsulated coccobacillus which causes infections worldwide. The objective of this study was to find a fungal strain that could be utilized to biosynthesize antibacterial silver nanoparticles (AgNPs) against Acinetobacter baumanii. The present investigation explains rapid and extracellular biosynthesis of silver nanoparticles by the algicolous endophytic fungus, Penicillium polonicum, isolated from the marine green alga Chetomorpha antennina. The obtained silver nanoparticles were characterized by UV-Vis spectroscopy, Raman spectroscopy, Fourier transformation infrared (FTIR), and Transmission electron microscopy (TEM)...
January 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29224317/-a-multicenter-retrospective-study-of-pathogenic-bacteria-distribution-and-drug-resistance-in-febrile-neutropenic-patients-with-hematological-diseases-in-shanghai
#8
J Zhu, J Hu, Y F Mao, F Y Chen, J Y Zhu, J M Shi, D D Yu, S G Hao, R Tao, P Liu, S Y Gu, J Hou, H Y He, A B Liang, Y Ding, L G Liu, Y H Xie, Q Zhu, Y H Yu, Y H Yao, W Chen, H L Xu, X H Han, C Wang
Objective: To investigate the pathogen spectrum distribution and drug resistance of febrile neutropenic patients with hematological diseases in Shanghai. Methods: A retrospective study was conducted on the clinical isolates from the febrile neutropenic patients hospitalized in the departments of hematology in 12 general hospitals in Shanghai from January 2012 to December 2014. The drug susceptibility test was carried out by Kirby-Bauer method. WHONET 5.6 software was used to analyze pathogenic bacteria and drug susceptibility data...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29075483/extended-spectrum-and-metalo-beta-lactamase-producing-airborne-pseudomonas-aeruginosa-and-acinetobacter-baumanii-in-restricted-settings-of-a-referral-hospital-a-neglected-condition
#9
Fithamlak Bisetegen Solomon, Fiseha Wadilo, Efrata Girma Tufa, Meseret Mitiku
BACKGROUND: Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment. The aim of this study was to determine the prevalence and pattern of antibiotic resistance, extended spectrum and metallo beta-lactamase producing P. aeruginosa and A. baumannii isolates from restricted settings of indoor air hospital environment. METHODS: A hospital-based cross-sectional study was conducted in Wolaita Sodo University Teaching and referral Hospital, Ethiopia from December 1/2015 to April 30/2015...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29063446/extensive-colonization-with-carbapenemase-producing-microorganisms-in-romanian-burn-patients-infectious-consequences-from-the-colectiv-fire-disaster
#10
L E Pirii, A W Friedrich, J W A Rossen, W Vogels, G I J M Beerthuizen, M K Nieuwenhuis, A M D Kooistra-Smid, E Bathoorn
Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29062249/a-retrospective-evaluation-of-blood-cultures-in-a-pediatric-intensive-care-unit-a-three-year-evaluation
#11
Ayşe Betül Ergül, Halit Işık, Yasemin Ay Altıntop, Yasemin Altuner Torun
AIM: In this study, it was aimed to retrospectively assess the frequency and antibiotic resistance of microorganisms isolated from blood cultures of patients in a pediatric intensive care unit. MATERIAL AND METHODS: The study was conducted on blood culture tests obtained from patients in a pediatric intensive care unit and sent to a microbiology laboratory between 2013 and 2016. The species and antibiotic susceptibilities were assessed in microorganisms isolated from the blood cultures...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28803189/efficacy-of-radiant-catalytic-ionization-to-reduce-bacterial-populations-in-air-and-on-different-surfaces
#12
Krzysztof Skowron, Katarzyna Grudlewska, Joanna Kwiecińska-Piróg, Grzegorz Gryń, Mścisław Śrutek, Eugenia Gospodarek-Komkowska
Air contamination by biological agents is often observed in medical or veterinary facilities and industrial plants. Bioaerosols may sediment and pose the surface contamination. Microorganisms present on them may become a source of infections among humans and food contamination. This study determined the use of oxidative gases, including ozone and peroxide, generated by the Radiant Catalytic Ionization (RCI) cell for the inactivation of Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella Enteritidis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus epidermidis, Bacillus subtilis, Clostridium sporogenes, Candida albicans, Aspergillus niger and Penicillium chrysogenumon in air and on different surfaces...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28724383/molecular-characterization-and-genetic-relatedness-of-clinically-acinetobacter-baumanii-isolates-conferring-increased-resistance-to-the-first-and-second-generations-of-tetracyclines-in-iran
#13
Zahra Meshkat, Himen Salimizand, Yousef Amini, Mostafa Khakshoor, Davoud Mansouri, Hadi Farsiani, Kiarash Ghazvini, Adel Najafi
BACKGROUND: The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. By comparing genetic characteristics and relatedness of A. baumannii isolates, we are able to determine the transition dynamics of outbreak isolates. METHODS: A total of 72 non-duplicate isolates of A...
July 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28535606/isolation-purification-and-characterization-of-five-active-diketopiperazine-derivatives-from-endophytic-streptomyces-suk-25-with-antimicrobial-and-cytotoxic-activities
#14
Muhanna Alshaibani, Noraziah Zin, Juriyati Jalil, Nik Sidik, Siti Junaidah Ahmad, Nurkhalida Kamal, Ruangelie Edrada-Ebel
In our search for new sources of bioactive secondary metabolites from Streptomyces sp., the ethyl acetate extracts from endophytic Streptomyces SUK 25 afforded five active diketopiperazine (DKP) compounds. The aim of this study was to characterize the bioactive compounds isolated from endophytic Streptomyces SUK 25 and evaluate their bioactivity against multiple drug resistance (MDR) bacteria such as Enterococcus raffinosus, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter spp...
July 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28465626/synthesis-and-biological-evaluation-of-indole-core-based-derivatives-with-potent-antibacterial-activity-against-resistant-bacterial-pathogens
#15
Wei Hong, Jingyang Li, Zhe Chang, Xiaoli Tan, Hao Yang, Yifan Ouyang, Yanhui Yang, Sargit Kaur, Ian C Paterson, Yun Fong Ngeow, Hao Wang
The emergence of drug resistance in bacterial pathogens is a growing clinical problem that poses difficult challenges in patient management. To exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. Here we describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by molecular modeling to be potential glycosyltransferase inhibitors. Twenty of these derivatives were found to show in vitro inhibition of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus...
July 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28462048/pitfalls-associated-with-evaluating-enzymatic-quorum-quenching-activity-the-case-of-moml-and-its-effect-on-pseudomonas-aeruginosa-and-acinetobacter-baumannii-biofilms
#16
Yunhui Zhang, Gilles Brackman, Tom Coenye
BACKGROUND: The enzymatic degradation of quorums sensing (QS) molecules (called quorum quenching, QQ) has been considered as a promising anti-virulence therapy to treat biofilm-related infections and combat antibiotic resistance. The recently-discovered QQ enzyme MomL has been reported to efficiently degrade different N -acyl homoserine lactones (AHLs) of various Gram-negative pathogens. Here we investigated the effect of MomL on biofilms formed by two important nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii ...
2017: PeerJ
https://www.readbyqxmd.com/read/28434558/resistance-profiles-and-risk-factors-of-resistant-microorganisms-in-bacteraemia-of-abdominal-origin
#17
J Martín Jaramago, R Armero Ibáñez, J J Camarena Miñana, M Morales Suárez-Varela
OBJECTIVE: The presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. The objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. MATERIAL AND METHODS: A clinical, observational, epidemiological, retrospective cohort study was conducted with all the adult patients admitted to a university hospital from 2011-2013...
April 20, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28410511/evaluation-of-intraventricular-colistin-utilization-a-case-series
#18
Brian Gilbert, Christopher Morrison
PURPOSE: Multi-drug resistant organisms (MDROs) are an increasing concern in health systems. Pathogens such as Pseudomonas aeruginosa, Acinetobacter baumanii, and carbapenamase-producing Enterobacteriaceae hold highest mortality rates especially when the central nervous system is involved. When MDROs are cultured treatment options are limited and reliance on medications such as colistin is becoming more prevalent. Penetration of these therapies into the central nervous system is concerning therefore local administration is a potential concomitant therapy...
April 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28400958/in-vitro-evaluation-of-the-susceptibility-of-acinetobacter-baumannii-isolates-to-antiseptics-and-disinfectants-comparison-between-clinical-and-environmental-isolates
#19
Sanae Lanjri, Jean Uwingabiye, Mohammed Frikh, Lina Abdellatifi, Jalal Kasouati, Adil Maleb, Abdelouahed Bait, Abdelhay Lemnouer, Mostafa Elouennass
BACKGROUND: This study aims to assess the susceptibility of Acinetobacter baumannii isolates to the antiseptics and disinfectants commonly used, and to the non-approved product. METHODS: This is a prospective study carried out from February to August 2015, in the Bacteriology department of Mohammed V Military Teaching hospital of Rabat on A.baumannii isolates collected from colonized and/or infected patients and environmental samples. The antiseptics and disinfectants susceptibility testing was assessed using the micromethod validated in our department...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28384861/molecular-characterization-of-multidrug-resistant-strains-of-acinetobacter-baumannii-isolated-from-intensive-care-units-in-west-of-iran
#20
Parviz Mohajeri, Abbas Farahani, Rasa Sheini Mehrabzadeh
INTRODUCTION: According to the results of various studies using phenotypic methods, the prevalence of Multidrug Resistant (MDR) Acinetobacter baumannii (A. baumannii) isolates has been increasing worldwide. Pulsed-Field Gel Electrophoresis (PFGE) technique is known as the gold standard method to determine clonal characterization of bacterial species, especially A. baumannii. AIM: To determine the clonal relatedness and investigate the prevalence of integron classes 1 and 2 and genes encoding OXA-23 and 24 in A...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
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