Kristin Skogstrand, Christian Munch Hagen, Nis Borbye-Lorenzen, Michael Christiansen, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Thomas Werge, Anders Børglum, Ole Mors, Merethe Nordentoft, Preben Bo Mortensen, David Michael Hougaard
Mental disorders have for the majority of cases an unknown etiology, but several studies indicate that neurodevelopmental changes happen in utero or early after birth. We performed a nested case-control study of the relation between blood levels of neuro-developmental (S100B, BDNF, and VEGF-A) and inflammatory (MCP-1, TARC, IL-8, IL-18, CRP, and IgA) biomarkers in newborns, and later development of autism spectrum disorders (ASD, N = 751), attention deficit hyperactivity disorders (ADHD, N = 801), schizophrenia (N = 1969), affective (N = 641) or bipolar disorders (N = 641)...
October 7, 2019: Translational Psychiatry