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TARc in childrens

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https://www.readbyqxmd.com/read/27028543/levels-of-immunoglobulin-e-specific-to-the-major-food-allergen-and-chemokine-c-c-motif-ligand-ccl-17-thymus-and-activation-regulated-chemokine-and-ccl22-macrophage-derived-chemokine-in-infantile-atopic-dermatitis-on-ishigaki-island
#1
Hitokazu Esaki, Satoshi Takeuchi, Norihiro Furusyo, Kazuhiko Yamamura, Sayaka Hayashida, Gaku Tsuji, Masaki Takemura, Jun Hayashi, Masutaka Furue
Atopic dermatitis (AD) is a multifactorial T-helper (Th)2-mediated skin disease frequently associated with elevated serum immunoglobulin (Ig)E and food allergy is also a Th2- and IgE-mediated adverse immunological reaction. Our previous study indicated the relation of egg allergy history and disease severity of AD. Thus, the purpose of the study was to investigate the levels of IgE specific to major food allergens (egg, milk, wheat) and Th2 chemokines (chemokine [C-C motif] ligand [CCL]17/thymus and activation regulated chemokine [TARC] and CCL22/macrophage-derived chemokine [MDC]) and the relationship between them...
March 30, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26337791/plasma-levels-of-monokine-induced-by-interferon-gamma-chemokine-c-x-x-motif-ligand-9-thymus-and-activation-regulated-chemokine-chemokine-c-c-motif-ligand-17-in-children-with-kawasaki-disease
#2
Siqi Feng, Shiv Kumar Yadav, Fang Gao, Qijian Yi
BACKGROUND: Monokines induced by interferon-gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL)...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/26182268/-association-of-single-nucleotide-polymorphisms-in-tarc-ccl17-gene-with-kawasaki-disease-and-its-clinical-characteristics
#3
Fan Liu, Yan Ding, Wei Yin
OBJECTIVE: To study the association of single nucleotide polymorphisms (SNPs, rs223895 and rs223899) in TARC/CCL17 gene with Kawasaki disease (KD) and its clinical characteristics in Han children from Central China. METHODS: A case-control study was performed on 218 children with KD and 248 normal control children. The genotypes of SNPs (rs223895 and rs223899) in TARC/CCL17 gene were determined by polymerase chain reaction-restriction fragment length polymorphism...
July 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/26102348/chemokine-levels-in-serum-of-children-with-atopic-dermatitis-with-regard-to-severity-and-sensitization-status
#4
Birgit Ahrens, Gabriele Schulz, Johanna Bellach, Bodo Niggemann, Kirsten Beyer
BACKGROUND: Many infants with atopic dermatitis (AD) are sensitized against food or airborne allergens. The severity of AD, using the SCORAD, seems to correlate with elevated serum levels of TARC/CCL17. Other chemokines, such as CCL20 or CCL25, have been described in the context of allergic inflammation. The aim of this study was to analyze whether chemokine serum levels differ within a cohort of infants suffering from varying severities of AD with or without allergic sensitization. METHODS: Chemokine serum levels (CCL8, CCL17, CCL20, CCL25) as well as food and airborne allergen-specific IgE were analyzed in infants with AD...
November 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/25883801/chemokine-levels-and-parasite-and-allergen-specific-antibody-responses-in-children-and-adults-with-severe-or-uncomplicated-plasmodium-falciparum-malaria
#5
B Wangala, A Vovor, R G Gantin, Y F Agbeko, C J Lechner, X Huang, P T Soboslay, C Köhler
Chemokine and antibody response profiles were investigated in children and adults with severe or uncomplicated Plasmodium falciparum malaria; the aim was to reveal which profiles are associated with severe disease, as often seen in nonimmune children, or with mild and uncomplicated disease, as seen in semi-immune adults. Blood samples were obtained from children under 5 years of age as well as adults with falciparum malaria. Classification of malaria was performed according to parasite densities and hemoglobin concentrations...
March 2015: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/25546419/directional-secretory-response-of-double-stranded-rna-induced-thymic-stromal-lymphopoetin-tslp-and-ccl11-eotaxin-1-in-human-asthmatic-airways
#6
Gustavo Nino, Shehlanoor Huseni, Geovanny F Perez, Krishna Pancham, Humaira Mubeen, Aleeza Abbasi, Justin Wang, Stephen Eng, Anamaris M Colberg-Poley, Dinesh K Pillai, Mary C Rose
BACKGROUND: Thymic stromal lymphoproetin (TSLP) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma. This study investigated whether virally-induced secretion of TSLP is directional in nature (apical vs. basolateral) and/or if there are TSLP-mediated effects occurring at both sides of the bronchial epithelial barrier in the asthmatic state. METHODS: Primary human bronchial epithelial cells (HBEC) from control (n = 3) and asthmatic (n = 3) donors were differentiated into polarized respiratory tract epithelium under air-liquid interface (ALI) conditions and treated apically with dsRNA (viral surrogate) or TSLP...
2014: PloS One
https://www.readbyqxmd.com/read/25530136/clinical-and-immunological-effects-of-a-forest-trip-in-children-with-asthma-and-atopic-dermatitis
#7
Sung Chul Seo, Su Jin Park, Chan-Woo Park, Won Suck Yoon, Ji Tae Choung, Young Yoo
Asthma and atopic dermatitis are common allergic diseases, and their prevalence has increased in urban children. Recently, it is becoming understood that forest environment has favorable health effects in patients with chronic diseases. To investigate favorable clinical and immunologic effects of forest, we examined changes in clinical symptoms, indirect airway inflammatory marker, and serum chemokines before and after a short-term forest trip. The forest trips were performed with 21 children with asthma and 27 children with atopic dermatitis...
February 2015: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/25350554/incidence-serum-ige-and-tarc-ccl17-levels-in-atopic-dermatitis-associated-with-other-allergic-diseases-an-update-from-the-ishigaki-cohort
#8
Satoshi Takeuchi, Hitokazu Esaki, Norihiro Furusyo, Sayaka Hayashida, Kazuhiko Yamamura, Gaku Tsuji, Masaki Takemura, Jun Hayashi, Masutaka Furue
Population cohort studies are important for understanding the current status of the target disease and its relation to comorbidity, gender, age, or environmental factors. To better understand atopic dermatitis (AD) and its related diseases, we initiated in 2001 a population cohort study of nursery school children from Ishigaki Island, Okinawa, Japan. The cohort study comprised a dermatologist-based physical examination, questionnaire administration, and blood sample analysis. The mean prevalence of AD was 6...
April 2015: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/25312097/different-effect-of-oral-cyclosporine-therapy-and-oral-antihistamine-therapy-on-serum-high-sensitivity-c-reactive-protein-level-and-thymus-and-activation-regulated-chemokine-level-in-atopic-dermatitis-in-older-children-and-adulthood
#9
COMPARATIVE STUDY
Tsutomu Ohtsuka
BACKGROUND: Many patients with atopic dermatitis (AD) are treated with oral cyclosporine or antihistamine therapy in clinical practice. OBJECTIVE: To evaluate the effectiveness of oral cyclosporine and antihistamine therapy on clinical and laboratory findings in patients with AD. SUBJECTS AND METHODS: Twenty-five patients with AD (male-female = 11 : 14, age 16-42 years old, mean 26.2 years old) were treated with oral cyclosporine therapy. Twenty-three patients with AD (male-female = 10 : 13, age 15-32 years old, mean 24...
June 2015: International Journal of Dermatology
https://www.readbyqxmd.com/read/25277868/drawing-trauma-the-therapeutic-potential-of-witnessing-the-child-s-visual-testimony-of-war
#10
Lisa Farley, Aparna Mishra Tarc
Countertransference plays an often neglected role in witnessing children's testimony of war and trauma. A dual notion of countertransference, based on the work of Winnicott and Klein, is offered that involves both internal conflict related to early life experience and socially mediated notions of childhood, war, and trauma circulating in a given time and place. A drawing by a thirteen-year-old boy living in the refugee camps in Darfur is used to show how countertransference affects our interpretation of the image, even while its symbolization in language establishes the conditions for a potentially therapeutic response...
October 2014: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/24698291/serum-immunoglobulin-free-light-chain-levels-are-higher-in-girls-than-boys-during-eosinophilic-oesophagitis
#11
Karen Knipping, Diana Colson, Pascale Soulaines, Frank Redegeld, Johan Garssen, Christophe Dupont
AIM: Eosinophilic oesophagitis (EO) is an emerging worldwide disease, closely associated with male gender and allergic disorders. This study investigated the distribution of allergy markers in a cohort of children with EO. METHODS: We analysed allergy markers in 91 children (62 males and 29 females) with EO and a control group of 45 age-matched children who had non-EO gastrointestinal allergic symptoms. The markers analysed were serum cow's milk-specific and hen's egg-specific IgE, thymic stromal lymphopoietin (TSLP), thymus-regulated and activation-regulated chemokine (TARC/CCL17) and immunoglobulin free light chain (Ig-fLC)...
July 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24375082/effect-of-camel-milk-on-thymus-and-activation-regulated-chemokine-in-autistic-children-double-blind-study
#12
RANDOMIZED CONTROLLED TRIAL
Shahid Bashir, Laila Y Al-Ayadhi
BACKGROUND: This study aimed to investigate the role of the effectiveness of camel milk (CM) (raw and boiled) on thymus and activation-regulated chemokine (TARC) serum levels and childhood autism rating scale (CARS) score in subjects with autism and compared to placebo group (cow milk). METHODS: Forty-five subjects diagnosed with autism were randomly assigned to receive boiled CM for group I (n = 15), raw CM for group II (n = 15), and placebo for group III (n = 15) for 2 wk...
April 2014: Pediatric Research
https://www.readbyqxmd.com/read/23942559/tarc-ccl17-gene-polymorphisms-and-expression-associated-with-susceptibility-and-coronary-artery-aneurysm-formation-in-kawasaki-disease
#13
Chiu-Ping Lee, Ying-Hsien Huang, Yu-Wen Hsu, Kuender D Yang, Hsu-Chen Chien, Hong-Ren Yu, Ya-Ling Yang, Chih-Lu Wang, Wei-Chiao Chang, Ho-Chang Kuo
BACKGROUND: Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. Thymus and activation-regulated chemokine/chemokine ligand 17 (TARC/CCL17) is one of the Th2 chemokines and has been suggested as a candidate gene for conferring susceptibility to Th2 associated with allergy diseases. This study examined the correlation between gene polymorphisms and plasma levels of TARC/CCL17 in patients with KD and the outcomes of KD. METHODS: A total of 381 KD patients and 564 controls were subjected to determination of five tagging single-nucleotide polymorphisms of TARC/CCL17...
November 2013: Pediatric Research
https://www.readbyqxmd.com/read/23816920/immunologic-effects-of-omalizumab-in-children-with-severe-refractory-atopic-dermatitis-a-randomized-placebo-controlled-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Shuba Rajashri Iyengar, Elizabeth G Hoyte, Angelica Loza, Salvatore Bonaccorso, David Chiang, Dale T Umetsu, Kari Christine Nadeau
BACKGROUND: Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the pathogenesis of AD. Omalizumab, an anti-IgE antibody indicated for use in allergic asthma, is implicated in regulating allergen presentation by dendritic cells and the T cell response during the effector phases of allergic disease...
2013: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/23782855/elevated-serum-levels-of-macrophage-derived-chemokine-and-thymus-and-activation-regulated-chemokine-in-autistic-children
#15
Laila Yousef Al-Ayadhi, Gehan Ahmed Mostafa
BACKGROUND: In some autistic children, there is an imbalance of T helper (Th)1/Th2 lymphocytes toward Th2, which may be responsible for the induction of the production of autoantibodies in these children. Th2 lymphocytes express CCR4 receptors. CCR4 ligands include macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC). They direct trafficking and recruitment of Th2 cells. We are the first to measure serum levels of CCR4 ligands in relation to the degree of the severity of autism...
2013: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/23306544/a-th17-and-th2-skewed-cytokine-profile-in-cystic-fibrosis-lungs-represents-a-potential-risk-factor-for-pseudomonas-aeruginosa-infection
#16
Kerstin Tiringer, Angela Treis, Petra Fucik, Mia Gona, Saskia Gruber, Sabine Renner, Eleonora Dehlink, Edith Nachbaur, Friedrich Horak, Peter Jaksch, Gerd Döring, Reto Crameri, Andreas Jung, Mascha K Rochat, Marcus Hörmann, Andreas Spittler, Walter Klepetko, Cezmi A Akdis, Zsolt Szépfalusi, Thomas Frischer, Thomas Eiwegger
RATIONALE: Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of lung function and reduced life expectancy. OBJECTIVES: To assess T-cell cytokine/chemokine production in clinically stable children with CF and evaluate the association between T-cell subtypes and susceptibility for infection with P. aeruginosa. METHODS: T-cell cytokine/chemokine profiles were measured in bronchoalveolar lavage fluid (BALF) from children with CF (n = 57; 6...
March 15, 2013: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/22633082/pregnancy-associated-inflammatory-markers-are-elevated-in-pregnant-women-with-systemic-lupus-erythematosus
#17
S Björkander, K Bremme, J-O Persson, R F van Vollenhoven, E Sverremark-Ekström, U Holmlund
During normal pregnancy a dampening in T cell-mediated immunity is compensated by an increased pro-inflammatory activity. Likewise, the autoimmune disease systemic lupus erythematosus (SLE) is associated with inflammatory activity and pregnancy complications occur frequently in women with SLE. The aim of this study was to elucidate how SLE influences the chemokine and cytokine balance during and after pregnancy. Blood samples were taken from pregnant women with or without SLE at second and third trimester and 8-12 weeks after pregnancy...
August 2012: Cytokine
https://www.readbyqxmd.com/read/22374529/-idiopathic-hypereosinophilic-syndrome-in-a-child-with-fever-and-hepatomegaly
#18
Shingo Morinaga, Kazutaka Takaki, Akiko Sada, Toshimitsu Matsui
Idiopathic hypereosinophilic syndrome (IHES) in children is a rare disorder. A 1-year-old girl presented to our hospital for evaluation of eosinophilia. At the onset, her white blood cell count in peripheral blood was 70,600/μl with 74% eosinophils. She had a high fever and mild hepatomegaly but had no remarkable evidence of organ involvement by CT, MRI and ultrasonography. She was diagnosed with IHES without any evidence of secondary eosinophilia, expression of the FIP1L1-PDGFRα fusion transcript, chromosomal abnormalities, and aberrant T-cell populations...
January 2012: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/22017510/serum-tarc-and-ctack-concentrations-in-children-with-atopic-dermatitis-allergic-asthma-and-urticaria
#19
Edyta Machura, Małgorzata Rusek-Zychma, Magdalena Jachimowicz, Magdalena Wrzask, Bogdan Mazur, Alicja Kasperska-Zajac
BACKGROUND:   Thymus and activation-regulated chemokine (TARC/CCL17) and cutaneous T cell-attracting chemokine (CTACK/CCL27) belong to the CC chemokine family, which plays an important role in immune-inflammatory processes. It has been demonstrated that serum concentrations of TARC and CTACK are increased in patients with various allergic diseases. AIM:   To compare serum TARC and CTACK concentrations between children with different clinical manifestation of mast cell-dependent diseases, such as atopic allergy and urticaria...
May 2012: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/21646806/an-8-year-old-boy-with-hypereosinophilic-syndrome
#20
Koa Hosoki, Mizuho Nagao, Kosei Iguchi, Toshiaki Ihara, Yoshiyuki Yamada, Masamune Higashigawa, Gail M Kephart, Hirohito Kita, Takao Fujisawa
Hypereosinophilic syndrome (HES) is a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia and tissue eosinophilia, resulting in a wide variety of clinical manifestations. We present the case of an 8-year-old boy with HES. He complained of recurrent abdominal pain, general fatigue, and diarrhea. Laboratory data showed marked eosinophilia, elevated total IgE with positive specific IgE antibodies to common inhalant and food allergens, and elevated serum CCL17/TARC...
2011: International Archives of Allergy and Immunology
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