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https://www.readbyqxmd.com/read/29473950/serine-proteinases-in-the-turnover-of-the-cartilage-extracellular-matrix-in-the-joint-implications-for-therapeutics
#1
REVIEW
David J Wilkinson, Maria Del Carmen Arques, Carmen Huesa, Andrew D Rowan
Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as matrix metalloproteinases (MMPs). Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilise pharmacological inhibitors against this class of proteinases...
February 23, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29470341/clinical-updates-in-women-s-health-care-summary-arthritis
#2
Debendra Pattanaik
Arthritis is a commonly encountered problem in daily clinical practice, and with an aging population it will be as prevalent as any other chronic illness, such as diabetes mellitus, hypertension, and hypercholesterolemia. Obstetrician-gynecologists often encounter patients with arthritic symptoms in their practices. They may find it challenging to identify the underlying cause of arthritis and provide recommendations, as well as provide obstetric care to patients with known arthritis. The monograph will discuss common forms of arthritis, diagnostic testing and appropriate management, and referral of patients who need specialized care...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29463934/total-hip-arthroplasty-for-patients-with-residual-poliomyelitis-at-a-mean-eight-years-of-follow-up
#3
Mayumi Sonekatsu, Motoki Sonohata, Masaru Kitajima, Shunsuke Kawano, Masaaki Mawatari
In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital...
February 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463360/severe-arthritic-changes-following-acetabular-labral-repair-and-femoroplasty-in-an-air-force-pilot
#4
Christopher J Sardon, Mathew L Resnick
BACKGROUND: Acetabular labral tears in the hip have become an increasingly common finding in active duty members due to improved diagnostic capabilities. This has led to a dramatic increase in operative management despite a lack of evidence to support clear long-term benefits. Literature review demonstrated overwhelmingly positive short-term outcomes for labral repairs; however, scattered case reports exist demonstrating debilitating outcomes in young patients, ultimately resulting in total hip arthroplasty...
February 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29456063/clinical-outcome-of-arthroscopic-lateral-retinacular-release-for-symptomatic-bipartite-patella-in-athletes
#5
Lamberto Felli, Matteo Formica, Stefano Lovisolo, Andrea Giorgio Capello, Mattia Alessio-Mazzola
PURPOSE: To report the results of arthroscopic lateral retinacular release without excision of the accessory fragment for treatment of symptomatic bipartite patella with a minimum 2-year follow-up. METHODS: We retrospectively reviewed all cases of symptomatic type III bipartite patella confirmed by radiographs, computed tomography, and magnetic resonance imaging and treated with arthroscopic lateral release from 2005 to 2015. Patients with history of knee fractures or surgery, concomitant meniscal or anterior cruciate ligament (ACL) procedures, and severe arthritic changes of the patellofemoral joint were excluded...
February 15, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29453810/a-case-control-study-and-meta-analysis-reveal-the-association-between-cox-2-g-765c-polymorphism-and-primary-end-stage-hip-and-knee-osteoarthritis
#6
Wei Huang, Chen Deng, Feng Tian, Weilu Gao, Zhenfei Ding, Xianliang Rao, Zongsheng Yin
BACKGROUND: Osteoarthritis (OA) is a popular arthrosis featured as pain, limited joint activity, and deformity. Cyclooxygenase-2 (COX-2) has been reported to be up-regulated in arthritic tissues and is integral to the progression of osteoarthritis (OA). Previous studies showed the COX-2 promoter G-765C polymorphism could influence COX-2 expression. However, the relationship between the variant and OA risk is contrasting. METHODS: We conducted a case-control study with 196 primary end-stage hip and knee OA cases and 196 controls in a Chinese Han population...
February 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29449195/neutrophil-microvesicles-from-healthy-control-and-rheumatoid-arthritis-patients-prevent-the-inflammatory-activation-of-macrophages
#7
Hefin I Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V Norling, Mauro Perretti
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage. MVs were generated in response to tumour necrosis factor-α, from healthy control neutrophils or those from rheumatoid arthritis patients. MVs were used to stimulate human monocyte-derived macrophages in vitro, or administered intra-articularly in the K/BxN mouse model of arthritis...
February 7, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#8
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. MATERIALS AND METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
February 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29441250/an-unusual-case-of-acute-chondrocalcinosis-in-wrist-joint-presenting-as-cellulitis
#9
Razia Awan, Haider Ghazanfar, Karen A Martes Pena, Rafi I Farkhad
Chondrocalcinosis is a common arthritic disorder among elderly patients. We present a case of a 71-year-old woman presenting with an acute episode of the left forearm with hand swelling. A provisional diagnosis of cellulitis was made and the patient was started on intravenous antibiotics. The patient's condition did not improve. Joint aspiration of the wrist joint was done and showed positive birefringent rhomboid-shaped crystals. A final diagnosis of acute chondrocalcinosis was made.
December 6, 2017: Curēus
https://www.readbyqxmd.com/read/29437062/mid-term-outcomes-of-routine-proximal-row-carpectomy-compared-with-proximal-row-carpectomy-with-dorsal-capsular-interposition-arthroplasty-for-the-treatment-of-late-stage-arthropathy-of-the-wrist
#10
COMPARATIVE STUDY
M P Gaspar, P P Pham, C D Pankiw, S M Jacoby, E K Shin, A L Osterman, P M Kane
AIMS: The aims of this study were to compare the mid-term outcomes of patients with late-stage arthritis of the wrist treated with proximal row carpectomy (PRC) and dorsal capsular interposition (DCI) arthroplasty with a matched cohort treated with routine PRC alone. PATIENTS AND METHODS: A total of 25 arthritic wrists (24 patients) with pre-existing degenerative changes of the proximal capitate and/or the lunate fossa of the radius were treated with PRC + DCI over a ten-year period...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29434332/the-p55tnfr-ikk2-ripk3-axis-orchestrates-arthritis-by-regulating-death-and-inflammatory-pathways-in-synovial-fibroblasts
#11
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
NFκB activation and regulated cell death are important in tissue homeostasis, inflammation and pathogenesis. Here we show the role of the p55TNFR-IKK2l-Ripk3 axis in the regulation of synovial fibroblast homeostasis and pathogenesis in TNF-mediated mouse models of arthritis. Mesenchymal-specific p55TNFR triggering is indispensable for arthritis in acute and chronic TNF-dependent models. IKK2 in joint mesenchymal cells is necessary for the development of cartilage destruction and bone erosion; however, in its absence synovitis still develops...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29425654/anti-inflammatory-and-anti-arthritic-effects-of-the-ethanolic-extract-of-aralia-continentalis-kitag-in-il-1%C3%AE-stimulated-human-fibroblast-like-synoviocytes-and-rodent-models-of-polyarthritis-and-nociception
#12
Riwon Hong, BongJun Sur, Mijung Yeom, Bombi Lee, Kyoung Soo Kim, Joyce P Rodriguez, Sanghyun Lee, Ki Sung Kang, Chang-Ki Huh, Sang Cheon Lee, Dae-Hyun Hahm
BACKGROUND: Blocking the formation and invasive growth of pannus and its secretion of inflammatory cytokines and MMPs is important for treating rheumatoid arthritis. HYPOTHESIS/PURPOSE: Anti-arthritic activity of Aralia continentalis Kitag., an oriental herbal medicine, and the underlying mechanisms involved were investigated. STUDY DESIGN: Anti-inflammatory and anti-nocicpetive activities of the ethanolic extract (50% v/v) of Aralia continentalis Kitag...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423253/clinical-outcomes-of-patients-with-symptomatic-acetabular-rim-fractures-after-arthroscopic-fai-treatment
#13
Brian D Giordano, Carlos Suarez-Ahedo, Chengcheng Gui, Nader Darwish, Parth Lodhia, Benjamin G Domb
This study aims to investigate the influence of the acetabular rim fractures on outcomes of hip arthroscopy at minimum 2-year follow-up. Between January 2009 and August 2012, data were prospectively collected on all patients undergoing hip arthroscopy. Anatomic findings, including presence of rim fractures, were recorded intraoperatively. Patients were assessed preoperatively and at 3 months, 1 year and minimum 2 years postoperatively with four patient-reported outcome measures: modified Harris Hip Score, Non-Arthritic Hip Score, Hip Outcome Score-Activities of Daily Living and Hip Outcome Score-Sport Specific Subscales...
January 2018: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29416136/proteinases-and-their-receptors-in-inflammatory-arthritis-an-overview
#14
REVIEW
Katerina Oikonomopoulou, Eleftherios P Diamandis, Morley D Hollenberg, Vinod Chandran
Proteinases are enzymes with established roles in physiological and pathological processes such as digestion and the homeostasis, destruction and repair of tissues. Over the past few years, the hormone-like properties of circulating proteinases have become increasingly appreciated. Some proteolytic enzymes trigger cell signalling via proteinase-activated receptors, a family of G protein-coupled receptors that have been implicated in inflammation and pain in inflammatory arthritis. Proteinases can also regulate ion flux owing to the cross-sensitization of transient receptor potential cation channel subfamily V members 1 and 4, which are associated with mechanosensing and pain...
February 8, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29415905/anti-inflammatory-effects-of-a-small-molecule-gastrin-releasing-peptide-receptor-antagonist-on-adjuvant-induced-rheumatoid-arthritis-in-rats
#15
Wen-Yi Mei, Ming-Jun Yu, Sen Yao, Kui-Ling Wang, Ri-Sheng Yao
The anti-inflammatory effects of (R)-2-(1H-imidazol-1-yl) ethyl-3-(1H-indol-3- yl)-2-(2-p-tolylacetamido)propanamide (RH-1402), a previous designed small molecule Gastrin releasing peptide (GRP) antagonist were evaluated in adjuvant-induced arthritic model of rats, and the inhibitory effect on neutrophil migration induced by GRP was determined by a transwell system experiment in vitro. The arthritis was induced by injection of Complete Freund's Adjuvant (CFA) containing 10 mg/mL of heat killed mycobacterium into the left hind footpad...
February 8, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29413775/a-comparative-prospective-cohort-health-economic-analysis-comparing-ankle-fusion-isolated-great-toe-fusion-and-hallux-valgus-surgery
#16
David T Loveday, Lynne V Barr, Constantinos L Loizou, Garry Barton, George Smith
BACKGROUND: This study assessed the health economics and outcomes of three common foot and ankle operations. METHODS: Between July 2013 and October 2014 all patients undergoing ankle fusion (AF) for osteoarthritis, first metatarsophalangeal joint fusion for osteoarthritis (MF) or hallux valgus surgery (HV) were included. Patients having additional procedures were excluded. Patients completed the Manchester-Oxford Foot Questionnaire (MOX-FQ), the EuroQol EQ-5D-5L questionnaire and the EQ-VAS on presentation and at least 6 months post-operatively...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29413189/editorial-commentary-wrist-ulnar-impaction-syndrome-when-i-use-the-wafer-procedure-and-when-i-do-not
#17
EDITORIAL
Matthew M Tomaino
Ulnar impaction syndrome is fundamentally a clinical diagnosis, which can be confirmed by magnetic resonance imaging. All palmer stages are amenable to surgical treatment with either arthroscopic wafer procedure (AWP) or ulnar shortening osteotomy, and neither the absence of a triangular fibrocartilage complex perforation nor neutral or negative variance contraindicate either. Because of its minimally invasive value proposition and likely success, there are few clinical scenarios for which I do not perform AWP preferentially...
February 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29409235/the-arthroereisis-procedure-in-adult-flexible-flatfoot-grade-iia-due-to-insufficiency-of-posterior-tibial-tendon
#18
P Ceccarini, G Rinonapoli, G Gambaracci, M Bisaccia, A Ceccarini, A Caraffa
BACKGROUND: To report on the functional, biomechanical, and radiographic results of patients who had undergone arthroereisis plus tensioning of the posterior tibial tendon for flexible flatfoot. The hypothesis is that arthroereisis associated to a tensioning of the posterior tibial tendon give a good correction with great satisfaction in patients with flexible flatfoot in grade IIA. METHODS: We evaluated 29 patients (31 feet), mean age of 46.4 years, who had been surgically treated for adult flatfoot grade IIA according to Myerson...
April 14, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29408170/acute-phase-reactant-pentraxin-3-as-a-novel-marker-for-the-diagnosis-of-rheumatoid-arthritis
#19
A Sharma, R Khan, N Gupta, A Sharma, M S Zaheer, M Abbas, S A Khan
INTRODUCTION: Pentraxins are a group of highly conserved acute-phase reactant proteins and play crucial role as modulators of inflammatory processes. Pentraxin 3 (PTX3) is primarily produced and released by vascular cell wall, hence, we attempt to establish the role of PTX3 as a biomarker for Rheumatoid Arthritis (RA) compared to CRP. METHODS: Thirty patients having active RA as cases and 30 osteoarthritis (OA) patients as controls were recruited. Paired serum and synovial fluid samples were analysed for concentrations of both PTX3 and CRP by using high sensitivity ELISA kit and ROC curve was plotted...
February 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29404675/detection-of-shigella-spp-nucleic-acids-in-the-synovial-tissue-of-tunisian-rheumatoid-arthritis-patients-and-other-forms-of-arthritis-by-quantitative-real-time-polymerase-chain-reaction
#20
Mariam Siala, Markus Rihl, Hanen Sellami, Abir Znazen, Nadia Sassi, Lilia Laadhar, Radhouane Gdoura, Imen Belghuith, Dalila Mrabet, Sofien Baklouti, Slaheddine Sellami, Jean Sibilia, Hela Fourati, Adnene Hammami, Ilhem Cheour
Enterobacterial components in the joints of patients are believed to contribute to a perpetuating inflammation leading to a reactive arthritis (ReA), a condition in which microbial agents cannot be recovered from the joint. At present, it is unclear whether nucleic acids from Shigella spp. are playing a pathogenic role in causing not only ReA but also other forms of arthritis. Quantitative real-time polymerase chain reaction assay (qPCR) is the method of choice for the identification of bacteria within the synovium...
February 5, 2018: Rheumatology International
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