keyword
MENU ▼
Read by QxMD icon Read
search

Arthrit

keyword
https://www.readbyqxmd.com/read/28654765/a-traffic-light-grading-system-of-hip-dysplasia-to-predict-the-success-of-arthroscopic-hip-surgery
#1
George Grammatopoulos, Owain L I Davies, Ahmed El-Bakoury, Harinderjit S Gill, Tom C B Pollard, Antonio J Andrade
BACKGROUND: The role of hip arthroscopic surgery in dysplasia is controversial. PURPOSE: To determine the 7-year joint preservation rate after hip arthroscopic surgery in hip dysplasia and identify anatomic and intraoperative features that predict the success of hip preservation with arthroscopic surgery, allowing the formulation of an evidence-based classification system. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Between 2008 and 2013, 111 hips with dysplastic features (acetabular index [AI] >10° and/or lateral center-edge angle [LCEA] <25°) that underwent arthroscopic surgery were identified...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28651649/relationship-between-knee-osteoarthritis-and-meniscal-shape-in-observation-of-japanese-patients-by-using-magnetic-resonance-imaging
#2
Tsuneo Kawahara, Takahisa Sasho, Joe Katsuragi, Takashi Ohnishi, Hideaki Haneishi
BACKGROUND: The aims of this study were to reveal the characteristics of the meniscal shape at each knee osteoarthritis (OA) severity level and to predict trends or patterns of the meniscal shape change as associated with knee OA progression. METHODS: Fifty-one patients diagnosed with knee OA based on X-ray and magnetic resonance (MR) images were evaluated. They were divided into three groups based on the Kellgren-Lawrence (KL) grade: normal group (KL grade of 0 or 1), mild group (KL grade of 2 or 3), and severe group (KL grade of 4)...
June 26, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28648920/ultrasound-assessment-of-human-meniscus
#3
Tuomas Viren, Juuso T Honkanen, Elvis K Danso, Lassi Rieppo, Rami K Korhonen, Juha Töyräs
The aim of the present study was to evaluate the applicability of ultrasound imaging to quantitative assessment of human meniscus in vitro. Meniscus samples (n = 26) were harvested from 13 knee joints of non-arthritic human cadavers. Subsequently, three locations (anterior, center and posterior) from each meniscus were imaged with two ultrasound transducers (frequencies 9 and 40 MHz), and quantitative ultrasound parameters were determined. Furthermore, partial-least-squares regression analysis was applied for ultrasound signal to determine the relations between ultrasound scattering and meniscus integrity...
June 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28638881/aristolochia-bracteolate-retz-attenuates-hyperuricemia-in-a-metabolic-arthritis-rat-model
#4
Yun-Peng Li, Shuang Wu, Afou Ran, Da-Yong Xu, Jing-Mei Wei, Zi-Long Zhao
BACKGROUND: The leaves of Aristolochia bracteolata Retz. has been documented in the folk medicine literature for its anti-arthritic activity. The target of the research envisaged was to elucidate the activity of A. bracteolata extract on hyperuricemic condition in arthritis rat model. MATERIALS AND METHODS: Dried and powdered plant leaves were extracted using ether and chloroform. Potassium oxonate was injected intra-articularly to produce arthritis. The hyperuricemic effect, of A...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28637509/genetic-effects-of-rs3740199-polymorphism-in-adam12-gene-on-knee-osteoarthritis-a-meta-analysis
#5
Zheng Hao, Xin Li, Jin Dai, Baocheng Zhao, Qing Jiang
BACKGROUND: Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls. METHODS: A comprehensive search was performed to identify related studies up to April 14, 2017...
June 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28636468/do-ligamentum-teres-tears-portend-inferior-outcomes-in-patients-with-borderline-dysplasia-undergoing-hip-arthroscopic-surgery-a-match-controlled-study-with-a-minimum-2-year-follow-up
#6
Edwin O Chaharbakhshi, Itay Perets, Lyall Ashberg, Brian Mu, Christopher Lenkeit, Benjamin G Domb
BACKGROUND: Arthroscopic surgery in borderline dysplastic hips remains controversial, but the role of the ligamentum teres (LT) has not been studied in this setting. HYPOTHESIS: Borderline dysplastic patients with LT tears have worse short-term outcomes than those without LT tears. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were prospectively collected on patients who underwent arthroscopic surgery between February 2008 and April 2014...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28636167/berberine-ameliorates-collagen-induced-arthritis-in-rats-by-suppressing-th17-cell-responses-via-inducing-cortistatin-in-the-gut
#7
Mengfan Yue, Yufeng Xia, Can Shi, Chunge Guan, Yunfan Li, Rui Liu, Zhifeng Wei, Yue Dai
Berberine, an isoquinoline alkaloid, has been reported to ameliorate various autoimmune diseases including rheumatoid arthritis by oral administration. However, its mechanism remains mysterious due to an extremely low bioavailability. The fact that berberine is easy to accumulate in gut, the largest endocrine organ in the body, attracts us to explore its anti-arthritic mechanism in view of the induction of intestinal immunosuppressive neuropeptides. In this study, berberine (200 mg/kg, i.g.) was shown to ameliorate collagen-induced arthritis in rats, which was manifested by the reduction of clinical signs and joint destruction, as well as marked down-regulation of Th17 cell frequency and IL-17 level in blood...
June 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28630726/the-hapi-hip-arthroscopy-pre-habilitation-intervention-study-does-pre-habilitation-affect-outcomes-in-patients-undergoing-hip-arthroscopy-for-femoro-acetabular-impingement
#8
Louise F Grant, Derek J Cooper, Jon L Conroy
The purpose of this randomized prospective comparative controlled pilot study was to determine whether specific patient exercises done pre-hip arthroscopy surgery for femoro-acetabular impingement affected post-operative recovery. Between October 2013 and June 2014, 6 males and twelve females over the age of eighteen, who were listed for hip arthroscopy for femoro-acetabular impingement, were randomized into two groups. A hip-specific, 8-week home exercise programme was given to the experimental group before their surgery...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630719/hip-arthroscopy-results-in-improved-patient-reported-outcomes-compared-to-non-operative-management-of-waitlisted-patients
#9
Luke Spencer-Gardner, Ruch Dissanayake, Amir Kalanie, Parminder Singh, John O'Donnell
Hip arthroscopy (HA) is an established treatment option to address intra-articular pathology of the hip. However, some clinicians encourage non-operative management (NOM). Non-operative management may include active measures such as physiotherapy and intra-articular steroid injections, or NOM may involve so called watchful waiting with no active intervention. These approaches, along with surgery have been detailed recently in the Warwick Agreement, a Consensus Statement regarding diagnosis and treatment of Femoroacetabular Impingement Syndrome The aim of this study is to compare the change in clinical outcome scores of waitlisted patients with intra-articular hip pathology who receive no active treatment with matched controls that have undergone HA...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630715/can-hip-arthroscopy-in-the-presence-of-arthritis-delay-the-need-for-hip-arthroplasty
#10
REVIEW
A Viswanath, V Khanduja
Hip arthroscopy for joint preservation surgery has grown immensely over the last two decades. There is now an increasing trend to try and expand the role of hip arthroscopy to include patients of an older age or perhaps even with signs of arthritis, instead of the established patient group of young adults with mechanical symptoms or serious athletes. But how much of this growth is really justified? Once arthritis is apparent, the arthroscopic procedures needed to try and limit progression of the disease are likely to be different to those needed in young adult non-arthritic hips...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28629364/changes-in-concentrations-of-haemostatic-and-inflammatory-biomarkers-in-synovial-fluid-after-intra-articular-injection-of-lipopolysaccharide-in-horses
#11
Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T Kristensen, Stine Jacobsen
BACKGROUND: Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28628468/dapsa-das28-and-mda-predict-long-term-treatment-regime-in-psoriatic-arthritis-the-swedish-early-psoriatic-arthritis-cohort
#12
Ulla Lindqvist, Mona-Lisa Wernroth, Tomas Husmark, Per Larsson, Mats Geijer, Annika Teleman, Elke Theander, Gerd-Marie Alenius
OBJECTIVES: To describe treatment patterns in the Swedish early psoriatic arthritis cohort (SwePsA) of the mono-/oligo-arthritic (M/O) and polyarthritis (P) and identify early predictive factors for treatment with disease-modifying anti-rheumatic (DMARD), non-steroidal anti-inflammatory drugs (NSAID), and tumour necrosis factor inhibition (TNFi) after 5 years. METHODS: Data for 198 M/O and P PsA were obtained within the programme for SwePsA. Multinomial and binary logistic regression analyses were used to assess the association between early predictive factors and treatment after 5 years adjusted for age at inclusion...
June 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28626855/a-scaling-method-to-individualise-muscle-force-capacities-in-musculoskeletal-models-of-the-hand-and-wrist-using-isometric-strength-measurements
#13
Benjamin Goislard de Monsabert, G Rao, A Gay, E Berton, L Vigouroux
Because the force-generating capacities of muscles are currently estimated using anatomical data obtained from cadaver specimens, hand musculoskeletal models provide only a limited representation of the specific features of individual subjects. A scaling method is proposed to individualise muscle capacities using dynamometric measurements and electromyography. For each subject, a strength profile was first defined by measuring net moments during eight maximum isometric contractions about the wrist and metacarpophalangeal joints...
June 19, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28624472/nonclinical-safety-of-astilbin-a-4-week-oral-toxicity-study-in-rats-with-genotoxicity-chromosomal-aberration-and-mammalian-micronucleus-tests
#14
Yonglin Gao, Chunmei Li, Yunzhi Wang, Yunguo Liu, Guisheng Li, Xiaochen Fan, Yanshen Li, Jingwei Tian, Albert W Lee
Astilbin is an active flavonoid compound isolated from Rhizoma Smilacis Glabrae. It has been widely used as an anti-hepatic, anti-arthritic, and anti-renal injury agent. However, its safety has not yet been established. The objective of this study was to evaluate 4-week repeated oral toxicity and genotoxicity of astilbin. We examined oral toxicity in Sprague-Dawley rats after daily oral administration of astilbin at 50, 150, and 500 mg/kg for 4 weeks. Negative control animals received the same volume of the solvent...
June 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28623342/hif-1%C3%AE-knockdown-reduces-glycolytic-metabolism-and-induces-cell-death-of-human-synovial-fibroblasts-under-normoxic-conditions
#15
Manuel J Del Rey, Álvaro Valín, Alicia Usategui, Carmen M García-Herrero, María Sánchez-Aragó, José M Cuezva, María Galindo, Beatriz Bravo, Juan D Cañete, Francisco J Blanco, Gabriel Criado, José L Pablos
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribution of HIF-1α to the energy metabolism and survival of human synovial fibroblasts (SF) under normoxic conditions. HIF-1α was silenced using lentiviral vectors or small-interfering RNA (siRNA) duplexes. Expression analysis by qRT-PCR and western blot of known HIF-1α target genes in hypoxia demonstrated the presence of functional HIF-1α in normoxic SF and confirmed the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a HIF-1α target even in normoxia...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28616477/is-there-a-lyme-like-disease-in-australia-summary-of-the-findings-to-date
#16
REVIEW
Melissa Judith Chalada, John Stenos, Richard Stewart Bradbury
Lyme Borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the Borrelia burgdorferi sensu lato (B. burgdorferi s. l.) complex. It results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. In the last twenty-five years there have been over 500 reports of an Australian Lyme-like syndrome in the scientific literature. However, the diagnoses of Lyme Borreliosis made in these cases have been primarily by clinical presentation and laboratory results of tentative reliability and the true cause of these illnesses remains unknown...
December 2016: One Health
https://www.readbyqxmd.com/read/28615031/leucine-rich-alpha-2-glycoprotein-promotes-th17-differentiation-and-collagen-induced-arthritis-in-mice-through-enhancement-of-tgf-%C3%AE-smad2-signaling-in-na%C3%A3-ve-helper-t-cells
#17
Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada, Tetsuji Naka
BACKGROUND: Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that the imbalance between T helper 17 (Th17) cells and regulatory T cells (Treg) plays important roles in the pathogenesis of RA, LRG may affect arthritic pathology by enhancing the TGF-β-Smad2 pathway that is pivotal for both Treg and Th17 differentiation...
June 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28614768/melanocortin-4-receptor-agonist-ro27-3225-ameliorates-soleus-but-not-gastrocnemius-atrophy-in-arthritic-rats
#18
A B Gomez-Sanmiguel, M P Nieto-Bona, C Fernandez-Galaz, T Priego, A I Martin, A Lopez-Calderon
Adjuvant-induced arthritis in rats decreases body weight and muscle mass. Melanocyte stimulating hormone administration to arthritic rats decreases inflammation and skeletal muscle wasting. In this study, we investigate whether activation of melanocortin-4 receptor by RO27-3225 administration is able to prevent the effect of arthritis on the expression of muscle-specific E3 ubiquitin ligases and MyoD in two different muscles, gastrocnemius (a mainly fast type muscle) and soleus (slow type). Arthritis was induced in male Wistar rats by intradermal injection of Freund's adjuvant...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28611162/a-large-chronic-pericardial-effusion-in-an-ultramarathon-runner-with-anti-ccp-positive-rheumatoid-arthritis
#19
Thomas J McClelland, Rose Penfold, Stefan Kluzek, Navraj S Nagra
Pericardial effusions arise as an extra-articular manifestation of rheumatoid arthritis (RA). Pericardial effusions are often asymptomatic, particularly in the early phase, but patients are at risk of cardiac tamponade as the effusion progresses. We discuss the case of a 40-year-old male ultramarathon runner with RA who presented with mild pleuritic chest pain and exertional dyspnoea after a recent long-haul flight. Despite a relative tachycardia, his observations were otherwise unremarkable. His blood tests revealed a C-reactive protein (CRP) of 86 mg/L and an anti-cyclic citrullinated peptide (anti-CCP) titre of 360 units/mL...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28609644/outcomes-of-hip-arthroscopic-surgery-in-patients-with-t%C3%A3-nnis-grade-1-osteoarthritis-at-a-minimum-5-year-follow-up-a-matched-pair-comparison-with-a-t%C3%A3-nnis-grade-0-control-group
#20
Benjamin G Domb, Edwin O Chaharbakhshi, Danil Rybalko, Mary R Close, Jody Litrenta, Itay Perets
BACKGROUND: Studies on midterm outcomes of the arthroscopic treatment of femoroacetabular impingement (FAI) and labral tears with mild osteoarthritis (OA) are limited. PURPOSE: To evaluate outcomes of the arthroscopic treatment of FAI and labral tears in patients with mild preoperative OA (Tönnis grade 1) at a minimum 5-year follow-up, and to perform a matched-pair comparison to a control group with Tönnis grade 0. STUDY DESIGN: Cohort study; Level of evidence, 3...
June 1, 2017: American Journal of Sports Medicine
keyword
keyword
69842
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"