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Multivessel coronary artery disease

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https://www.readbyqxmd.com/read/29223429/predicting-risk-of-cardiac-events-among-st-segment-elevation-myocardial-infarction-patients-with-conservatively-managed-non-infarct-related-artery-coronary-artery-disease-an-analysis-of-the-duke-databank-for-cardiovascular-disease
#1
Sameer A Hirji, Susanna R Stevens, Linda K Shaw, Erin C Campbell, Christopher B Granger, Manesh R Patel, Michael H Sketch, Tracy Y Wang, E Magnus Ohman, Eric D Peterson, J Matthew Brennan
BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit likely depends on the risk of future major adverse cardiovascular events (MACE). METHODS: Using data from Duke University Medical Center (2003-2012), we identified those at high risk for 1-year MACE among 664 STEMI patients with conservatively managed non-infarct-related artery (non-IRA) lesions...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29214718/coronary-artery-disease-revascularization-and-clinical-outcomes-in-transcatheter-aortic-valve-replacement-real-world-results-from-the-east-denmark-heart-registry
#2
Oscar Millan-Iturbe, Fadi J Sawaya, Jacob Lønborg, Danny H F Chow, Gintautas Bieliauskas, Thomas Engstrøm, Lars Søndergaard, Ole De Backer
Transcatheter aortic valve replacement (TAVR) has become an established therapeutic option for patients with symptomatic, severe aortic stenosis. The optimal treatment strategy for concomitant coronary artery disease (CAD) has not been tested prospectively in a randomized clinical trial. This study aimed to describe the degree of CAD, revascularization strategies, and long-term clinical outcomes in a large-scale all-comers TAVR-population. Nine hundred and forty-four consecutive patients underwent TAVR. Obstructive CAD was reported in 224 patients (23...
December 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29211251/circulating-levels-of-adiponectin-and-extent-of-coronary-artery-disease-in-patients-undergoing-elective-coronary-angiography
#3
R A Souza, C M R Alves, C S V de Oliveira, A F Reis, A C Carvalho
Adiponectin (APN), an adipose tissue-released adipokine with demonstrated anti-inflammatory and anti-atherogenic properties, is encoded by a gene whose polymorphisms are associated with presence of coronary artery disease (CAD). Serum APN levels are inversely related with presence and complexity of CAD. Within this context, we sought to compare levels of total APN and its high molecular weight form (HMW APN) according to clinical presentation and extent of CAD in patients undergoing elective cardiac catheterization...
November 30, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#4
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29201152/myocardial-injury-in-diabetic-patients-with-multivessel-coronary-artery-disease-after-revascularization-interventions
#5
Paulo Cury Rezende, Whady Hueb, Rosa Maria Rahmi, Thiago Luis Scudeler, Diogo Freitas Cardoso de Azevedo, Cibele Larrosa Garzillo, Carlos Alexandre Wainrober Segre, Jose Antonio Franchini Ramires, Roberto Kalil Filho
Background: Diabetic patients may be more susceptible to myocardial injury after coronary interventions. Thus, the aim of this study was to assess the release of cardiac biomarkers, CK-MB and troponin, and the findings of new late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in patients with type 2 diabetes mellitus after elective revascularization procedures for multivessel coronary artery disease (CAD). Methods: Patients with multivessel CAD and preserved systolic ventricular function underwent either elective percutaneous coronary intervention (PCI), off-pump or on-pump bypass surgery (CABG)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29189828/-coronary-revascularization-in-patients-with-st-elevation-myocardial-infarction-and-multivessel-disease
#6
Giulia Bugani, Valerio Lanzillotti, Elisa Filippini, Giuseppe Di Pasquale, Gianluca Campo
Forty to 60% of ST-elevation myocardial infarction (STEMI) patients present with multivessel coronary artery disease, identified during primary percutaneous coronary intervention (pPCI) of the culprit lesion. At present, data about revascularization of non-culprit coronary lesions are conflicting. Nevertheless, patients with multivessel coronary artery disease have a worse outcome. Recently, several randomized controlled trials and meta-analyses compared a strategy of culprit-only revascularization vs complete revascularization (during pPCI or staged PCI of the non-culprit lesion)...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29185617/percutaneous-intervention-in-st-elevation-myocardial-infarction-culprit-only-or-complete-revascularization
#7
Ana Paula Susin Osório, Alexandre Schaan de Quadros, José Luiz da Costa Vieira, Vera Lucia Portal
The best approach of multivessel coronary artery disease in the context of acute myocardial infarction with ST segment elevation and primary percutaneous coronary intervention is one of the main reasons for controversy in cardiology. Although the main global guidelines do not recommend routine complete revascularization in these patients, recent randomized clinical trials have demonstrated benefit of this approach in reducing cardiovascular outcomes. For this reason, an adequate review of this evidence is essential in order to establish scientifically based strategy and achieve better outcomes for these patients who present with acute myocardial infarction...
November 27, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29162610/angiography-versus-hemodynamics-to-predict-the-natural-history-of-coronary-stenoses-a-fame-2-substudy
#8
Giovanni Ciccarelli, Emanuele Barbato, Gabor G Toth, Brigitta Gahl, Panagiotis Xaplanteris, Stephane Fournier, Anastasios Milkas, Jozef Bartunek, Marc Vanderheyden, Nico Pijls, Pim Tonino, William F Fearon, Peter Jüni, Bernard De Bruyne
Background -Among patients with documented stable coronary artery disease (CAD) and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and of fractional flow reserve (FFR) in predicting natural history. Methods -The present analysis included the 607 patients from the Fractional flow reserve versus angiography in multivessel evaluation 2 (FAME 2) trial in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74 ± 0...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29146627/single-session-versus-staged-procedures-for-elective-multivessel-percutaneous-coronary-intervention
#9
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Kyohei Yamaji, Kenji Ando, Koh Ono, Satoshi Shizuta, Naritatsu Saito, Takao Kato, Shuichiro Kaji, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Minoru Horie, Takeshi Kimura
OBJECTIVES: To clarify the effect of single-session multivessel percutaneous coronary intervention (PCI) strategy relative to the staged multivessel strategy on clinical outcomes in patients with stable coronary artery disease (CAD) or non-ST-elevation acute coronary syndrome. METHODS: In the Coronary REvascularisation Demonstrating Outcome Study in Kyoto PCI/coronary artery bypass grafting registry cohort-2, there were 2018 patients who underwent elective multivessel PCI...
November 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29142817/an-unusual-case-of-aortic-right-atrium-fistula-a-diagnostic-and-therapeutic-challenge
#10
Maria Chiara Todaro, Alessandro Aprile, Adriana Ravera, Gaetano Senatore
An aorta-to-right atrium (RA) fistula is an anomalous communication between the ascending or descending thoracic aorta and the RA. In this report, we describe a case of an idiopathic aortic root-to-RA fistula occasionally found during a coronary angiography performed in a young patient admitted for acute chest pain with evidence of multivessel coronary artery disease. The anatomical peculiarity of this fistulous communication is that it gave origin to collateral vessels furnishing the inferolateral wall of the left ventricle...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29138366/lower-repeat-revascularization-rates-among-patients-with-prior-coronary-artery-bypass-graft-surgery-are-due-to-lack-of-adequate-target-vessels
#11
Anirudh Kumar, John F Wagener, Daniel Wojdyla, W Schuyler Jones, Manesh R Patel, Sunil V Rao
BACKGROUND: Studies comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery in patients with multivessel coronary artery disease (CAD) have shown lower repeat revascularization rates in patients who undergo CABG. The reason remains unclear. METHODS: We identified patients with multivessel CAD who received CABG or PCI enrolled in the Duke Databank for Cardiovascular Disease (2003 to 2012). We compared the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) between the two groups...
November 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29135625/impact-of-sex-on-long-term-clinical-outcomes-after-percutaneous-coronary-intervention
#12
Seyed-Mohammad Ghoreyshi-Hefzabad, Seyed-Ebrahim Kassaian, Shahrbanoo Kheirkhah-Sabetghadam, Arash Jalali, Hamidreza Poorhosseini, Mohammad Reza Movahed, Ebrahim Nematipour, Mojtaba Salarifar, Mohammad Alidoosti, Seyedeharezoo Ghoreyshi-Hefzabad, Farshid Alaeddini, Saeed Sadeghian, Masoumeh Lotfi-Tokaldany
AIMS: To evaluate the impact of sex on long-term clinical outcomes after percutaneous coronary intervention (PCI). METHODS: In a large prospective cohort, 5664 patients (1716 women and 3948 men) who underwent PCI in a tertiary cardiac center between March 2007 and March 2010 were enrolled. Patients were followed up for median of 74.3 months. We compared the occurrence of long-term mortality, myocardial infarction (MI), and repeated revascularization between 2 sexes...
December 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29135483/coronary-periarteritis-associated-with-multivessel-coronary-artery-disease
#13
Kazushi Sakane, Ryoto Hourai, Masahiro Daimon, Koichi Sohmiya, Hiroko Kuwabara, Takahiro Katsumata, Michishige Ozeki, Yoshinobu Hirose, Nobukazu Ishizaka
No abstract text is available yet for this article.
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29132034/impact-of-flow-mediated-dilatation-and-coronary-calcification-in-providing-complementary-information-on-the-severity-of-coronary-artery-disease
#14
Kentaro Arakawa, Mutsuki Ohno, Mutsuo Horii, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura
BACKGROUND AND AIMS: Endothelial dysfunction and coronary artery calcification (CAC) may represent two distinct and separate processes in the development of coronary atherosclerosis. However, the interaction between these factors in determining the development of coronary artery disease (CAD) is uncertain. METHODS: Brachial artery flow-mediated dilatation (FMD) was measured by high-resolution ultrasound before coronary angiography, in 156 patients undergoing coronary CT angiography on suspicion of CAD (M/F 100/56, age 67 ± 11yrs)...
November 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29120880/culprit-versus-multivessel-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-trials
#15
Satyanarayana R Vaidya, Arman Qamar, Sameer Arora, Santhosh R Devarapally, Ashok Kondur, Prashant Kaul
BACKGROUND: The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite evidence supporting complete revascularization in STEMI, its benefit on mortality rates is uncertain. METHODS: We searched all available databases for randomized controlled trials comparing complete multivessel percutaneous coronary intervention (CMV PCI) with infarct-artery-only revascularization in patients with STEMI...
November 8, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29108293/gap-in-gender-parity-gender-disparities-in-incidence-and-clinical-impact-of-chronic-total-occlusion-in-non-infarct-artery-in-patients-with-non-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-artery-disease
#16
Mateusz Tajstra, Michał Hawranek, Piotr Desperak, Aneta Ciślak, Mariusz Gąsior
A chronic total occlusion in a non-infarct-related artery is an independent predictor of mortality in non-ST elevation myocardial infarction. There are no mortality data about the impact of a chronic total occlusion in patients with non-ST elevation myocardial infarction according to gender. The purpose of this study was to evaluate the prevalence of the chronic total occlusion in in men and women and examine its impact on clinical outcomes. Data from consecutive patients with multivessel coronary artery disease treated in a high-volume center between 2006 and 2012 were included in a prospective registry and divided according to gender and the presence of chronic total occlusion...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107589/metamizole-and-platelet-inhibition-by-aspirin-following-on-pump-coronary-artery-bypass-grafting
#17
Mirosław Wilczyński, Maciej T Wybraniec, Marek Sanak, Joanna Góral, Katarzyna Mizia-Stec
OBJECTIVE: The purpose of the study was to evaluate the impact of intravenous metamizole on platelet inhibition by aspirin in patients with coronary artery disease early after on-pump coronary artery bypass grafting (CABG). DESIGN: Prospective, single-blind, randomized trial. SETTING: Tertiary referal hospital. PARTICIPANTS: The study comprised 43 patients with multivessel coronary artery disease undergoing CABG. INTERVENTIONS: Patients were randomized to postoperative intravenous metamizole ± opioids (study group; n = 23) or opioids alone (control group; n = 20)...
June 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29097450/clinical-outcomes-and-cost-effectiveness-of-fractional-flow-reserve-guided-percutaneous-coronary-intervention-in-patients-with-stable-coronary-artery-disease-three-year-follow-up-of-the-fame-2-trial-fractional-flow-reserve-versus-angiography-for-multivessel
#18
William F Fearon, Takeshi Nishi, Bernard De Bruyne, Derek B Boothroyd, Emanuele Barbato, Pim Tonino, Peter Jüni, Nico H J Pijls, Mark A Hlatky
BACKGROUND : Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compared PCI guided by fractional flow reserve with best MT in patients with stable coronary artery disease to assess clinical outcomes and cost-effectiveness. METHODS : A total of 888 patients with stable single-vessel or multivessel coronary artery disease with reduced fractional flow reserve were randomly assigned to PCI plus MT (n=447) or MT alone (n=441)...
November 2, 2017: Circulation
https://www.readbyqxmd.com/read/29089340/genetic-variation-at-the-adamts7-locus-is-associated-with-reduced-severity-of-coronary-artery-disease
#19
Kenneth Chan, Xiangyuan Pu, Pratik Sandesara, Robin N Poston, Iain A Simpson, Arshed A Quyyumi, Shu Ye, Riyaz S Patel
BACKGROUND: Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data. METHODS AND RESULTS: The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29083953/pci-strategies-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#20
Holger Thiele, Ibrahim Akin, Marcus Sandri, Georg Fuernau, Suzanne de Waha, Roza Meyer-Saraei, Peter Nordbeck, Tobias Geisler, Ulf Landmesser, Carsten Skurk, Andreas Fach, Harald Lapp, Jan J Piek, Marko Noc, Tomaž Goslar, Stephan B Felix, Lars S Maier, Janina Stepinska, Keith Oldroyd, Pranas Serpytis, Gilles Montalescot, Olivier Barthelemy, Kurt Huber, Stephan Windecker, Stefano Savonitto, Patrizia Torremante, Christiaan Vrints, Steffen Schneider, Steffen Desch, Uwe Zeymer
Background In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial. Methods In this multicenter trial, we randomly assigned 706 patients who had multivessel disease, acute myocardial infarction, and cardiogenic shock to one of two initial revascularization strategies: either PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, or immediate multivessel PCI...
October 30, 2017: New England Journal of Medicine
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