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Gastric emptying scintigraphy

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https://www.readbyqxmd.com/read/27915009/exploring-gastrointestinal-variables-affecting-drug-and-formulation-behavior-methodologies-challenges-and-opportunities
#1
REVIEW
Bart Hens, Maura Corsetti, Robin Spiller, Luca Marciani, Tim Vanuytsel, Jan Tack, Arjang Talattof, Gordon L Amidon, Mirko Koziolek, Werner Weitschies, Clive G Wilson, Roelof J Bennink, Joachim Brouwers, Patrick Augustijns
Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27819785/-standardization-of-gastric-emptying-scintigraphy-with-egg-white-labeled-with-99mtc-sulfur-colloid
#2
Keren Contreras-Contreras, Rosa María Villanueva-Pérez, Diana Graciela Menez-Díaz, Laura Elena Iwasaki-Otake, Jorge Iván González-Díaz, Raúl Guillermo Mendoza-Vásquez
BACKGROUND: Gastric emptying scintigraphy has become the gold standard, by excellence, in gastric emptying studies. This method must be standardized for the correct interpretation of results. The ideal protocol must be performed with an egg sandwich or egg white poder, both labeled with 99mTc sulphur colloid. The aim of this study was to standardize and determine the protocol with99m Tc sulphur colloid incorporated in egg white and compare it with a hamburger labeled with 99mTc sulphur colloid as well...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27796517/gastric-motility-and-emptying-assessment-by-magnetic-resonance-imaging-after-lung-transplantation-correlation-with-gastric-emptying-scintigraphy
#3
Nobuyuki Hayakawa, Yuji Nakamoto, Toyofumi F Chen-Yoshikawa, Aki Kido, Takayoshi Ishimori, Koji Fujimoto, Tetsu Yamada, Masaaki Sato, Akihiro Aoyama, Hiroshi Date, Kaori Togashi
PURPOSE: Gastroparesis is a frequent gastrointestinal complication after lung transplantation. Although gastric emptying scintigraphy (GES) is the standard technique to evaluate gastroparesis, magnetic resonance imaging (MRI) can also assess gastric motility and emptying. This study compared the results obtained by these two modalities. METHODS: Twenty-two lung transplant recipients underwent MRI and GES after ingesting a small pancake as a test meal. Parameters assessed on MRI included antral peristaltic wave velocity and frequency, and the ratios of gastric content volume at 15 and 35 min...
October 31, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27781342/early-satiety-and-postprandial-fullness-in-gastroparesis-correlate-with-gastroparesis-severity-gastric-emptying-and-water-load-testing
#4
H P Parkman, E K Hallinan, W L Hasler, G Farrugia, K L Koch, L Nguyen, W J Snape, T L Abell, R W McCallum, I Sarosiek, P J Pasricha, J Clarke, L Miriel, J Tonascia, F Hamilton
BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2)...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27692912/the-effect-of-sleeve-gastrectomy-on-glp-1-secretion-and-gastric-emptying-a-prospective-study
#5
Federico Sista, Valentina Abruzzese, Marco Clementi, Sergio Carandina, Manuela Cecilia, Gianfranco Amicucci
BACKGROUND: Rapid gastric emptying has been proposed to justify the increase in glucagon-like polypeptide-1 (GLP-1) after laparoscopic sleeve gastrectomy (LSG). OBJECTIVES: To assess gastric emptying changes after LSG and their relationship with GLP-1 secretion. SETTING: San Salvatore Hospital general surgery unit, University of L'Aquila, Italy. METHODS: 52 patients underwent gastric emptying scintigraphy for liquid and solid foods, before and 3 months after LSG...
August 4, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27682148/gastrointestinal-transit-assessment-role-of-scintigraphy-where-are-we-now-where-are-we-going
#6
Harvey A Ziessman
The diagnostic imaging evaluation of patients with suspected esophagogastrointestinal transit disorders is changing. Anatomical methods, e.g., barium studies, endoscopy, manometry, radiopaque markers, have long been the techniques available and used for diagnosis. The one exception has been gastric emptying, where radionuclide scintigraphy has been the standard for decades. Esophageal transit scintigraphy is an old and reliable methodology but probably underutilized. The diagnostic use of small and large intestinal transit scintigraphy is increasing, in part, because of the limitations of the other methods but, most importantly, because it is truly physiologic, i...
September 28, 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27667753/regional-colonic-transit-pattern-does-not-conclusively-identify-evacuation-disorders-in-constipated-patients-with-delayed-colonic-transit
#7
Seon-Young Park, Duane Burton, Irene Busciglio, Deborah Eckert, Michael Camilleri
Background/Aims: After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender in patients with objectively slow colonic transit. Methods: We reviewed electronic medical records of 1553 constipated patients evaluated by a single gastroenterologist from 1994-2015 at a tertiary medical center...
September 25, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27667549/prevalence-and-predictors-of-delayed-gastric-emptying-among-indian-patients-with-long-standing-type-2-diabetes-mellitus
#8
Venkata Anudeep, Kolar Vishwanath Vinod, Nandini Pandit, Vivek Kumar Sharma, Halanaik Dhanapathi, Tarun Kumar Dutta, Akkilagunta Sujiv
BACKGROUND AND AIMS: Upper gastrointestinal symptoms are more prevalent among type 2 diabetes mellitus (T2DM) patients. The prevalence of delayed gastric emptying (GE) and factors predictive of it have not been studied in Indian T2DM patients and the present study aimed to study the same. METHODS: This hospital-based cross-sectional study involved adult (age between 18 and 65 years) outpatients with T2DM of ≥5-year duration. Measurements of GE of a labelled standardized solid rice idli meal by gastric emptying scintigraphy (GES), symptoms of delayed GE (by standardized questionnaire) and autonomic function by cardiovascular autonomic function tests (AFTs) were carried out...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27639387/a-double-blind-placebo-controlled-study-of-acotiamide-hydrochloride-for-efficacy-on-gastrointestinal-motility-of-patients-with-functional-dyspepsia
#9
Kumiko Nakamura, Toshihiko Tomita, Tadayuki Oshima, Haruki Asano, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Hirokazu Fukui, Fukushima Kazuhito, Shozo Hirota, Jiro Watari, Hiroto Miwa
BACKGROUND: Acotiamide is widely used to improve symptoms in patients with functional dyspepsia (FD) in multiple large-scale clinical studies, but there are few reports about the drug's mechanism of action. The aim of this study was to assess the effects of acotiamide on gastric accommodation and gastric emptying, gastrointestinal symptoms, and health-related quality of life (HR-QOL) in a placebo-controlled study. METHODS: We conducted a randomized, double-blind placebo-controlled study...
September 17, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27574563/update-on-diagnostic-value-of-breath-test-in-gastrointestinal-and-liver-diseases
#10
REVIEW
Imran Siddiqui, Sibtain Ahmed, Shahab Abid
In the field of gastroenterology, breath tests (BTs) are used intermittently as diagnostic tools that allow indirect, non-invasive and relatively less cumbersome evaluation of several disorders by simply quantifying the appearance in exhaled breath of a metabolite of a specific substrate administered. The aim of this review is to have an insight into the principles, methods of analysis and performance parameters of various hydrogen, methane and carbon BTs which are available for diagnosing gastrointestinal disorders such as Helicobacter pylori infection, small intestinal bacterial overgrowth, and carbohydrate malabsorption...
August 15, 2016: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/27563696/esophageal-and-gastric-dysmotilities-are-associated-with-altered-glucose-homeostasis-and-plasma-levels-of-incretins-and-leptin
#11
Rebecka Hammersjö, Bodil Roth, Peter Höglund, Bodil Ohlsson
BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry...
2016: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/27556100/peroral-endoscopic-pyloromyotomy-accelerates-gastric-emptying-in-healthy-pigs-proof-of-concept
#12
Sophie Geyl, Romain Legros, Aurélie Charissou, Laura Mesturoux, Claude-Yves Couquet, Paul Carrier, Anaïs Brayette, Zora El-Ouafi, Veronique Loustaud-Ratti, Denis Sautereau, Jacques Monteil, Jérémie Jacques
INTRODUCTION: Gastroparesis, or delayed gastric emptying, can be diagnosed with gastric emptying scintigraphy. Manometric studies of patients with gastroparesis show increased pyloric tone (pylorospasm). Among the recent endoscopic therapies for pylorospasm is peroral endoscopic pylorotomy (POP). In this study, we explored the effect of POP on gastric emptying in healthy pigs. MATERIAL AND METHODS: Four mini-pigs underwent POP following general anaesthesia. The mucosal entrance was situated 5 cm above the pylorus...
July 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27478028/gastric-per-oral-endoscopic-myotomy-with-antropyloromyotomy-in-the-treatment-of-refractory-gastroparesis-clinical-experience-with-follow-up-and-scintigraphic-evaluation-with-video
#13
Jean-Michel Gonzalez, Valentin Lestelle, Alban Benezech, Jonah Cohen, Véronique Vitton, Jean-Charles Grimaud, Marc Barthet
BACKGROUND AND AIMS: Gastroparesis is a chronic, debilitating condition. We report an experience conducting gastric per-oral endoscopic pyloromyotomy (G-POEM) with objectives to assess clinical efficacy, gastric emptying evolution, and procedural adverse events. METHODS: This was a clinical pilot series on 12 consecutive patients who underwent G-POEM for refractory gastroparesis in our tertiary center between February 2014 and August 2015. Patients included had severe disease as defined by elevated Gastroparesis Cardinal Symptoms Index (GCSI) score and delayed gastric emptying scintigraphy (GES)...
July 28, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27460691/effect-of-endoscopic-pyloric-therapies-for-patients-with-nausea-and-vomiting-and-functional-obstructive-gastroparesis
#14
Jennifer Wellington, Blake Scott, Sarba Kundu, Paula Stuart, Kenneth L Koch
: Gastroparesis (GP) is associated with loss of interstitial cells of Cajal (ICCs) and gastric dysrhythmias such as tachygastria. We hypothesized that a subset of patients with GP, normal 3cycles per minute (cpm) gastric myoelectrical activity (GMA), and normal upper endoscopy may respond to pyloric therapies. AIMS: To determine the effect of botulinum toxin A (btA) injection or balloon dilation (BD) of the pylorus on symptoms and body weight in patients with GP and 3cpm GMA...
July 16, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27400689/granisetron-transdermal-system-for-treatment-of-symptoms-of-gastroparesis-a-prescription-registry-study
#15
Deena Midani, Henry P Parkman
Background/Aims: Serotonin receptor (eg, 5-HT₃) antagonists are used to treat nausea and vomiting from a variety of causes. Granisetron transdermal system (GTS) is an appealing delivery system for patients with gastroparesis. To assess if GTS improves nausea and vomiting and other gastroparesis symptoms in patients with gastroparesis. Methods: Patients with gastroparesis and symptoms of nausea and vomiting refractory to conventional treatment were treated with GTS...
October 30, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27330004/delayed-absorption-of-many-paracetamol-aspirin-other-nsaids-and-zolmitriptan-but-not-all-sumatriptan-rizatriptan-drugs-during-migraine-attacks-and-most-likely-normal-gastric-emptying-outside-attacks-a-review
#16
Peer Carsten Tfelt-Hansen
BACKGROUND: In most pharmacokinetic studies, the oral absorption of drugs is impaired during migraine attacks but exceptions occur. A study on gastric emptying using gastric scintigraphy indicated that gastric stasis also occurs interictally in migraine. These studies were reviewed critically. RESULTS: In seven studies, mainly investigating NSAIDs and analgesics, the early absorption of the drugs during 112 migraine attacks was delayed. The absorption of sumatriptan is usual in therapeutic doses, and rizatriptan was normal during 131 migraine attacks...
June 20, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27318467/endoluminal-revision-overstitch-tm-apollo-endosurgery-of-the-dilated-gastroenterostomy-in-patients-with-late-dumping-syndrome-after-proximal-roux-en-y-gastric-bypass
#17
Christine Stier, Sonja Chiappetta
Dumping syndrome is a long-term postoperative complication of Roux-en-Y gastric bypass procedures. Morphologically, dumping syndrome usually correlates with a dilatation of the gastroenterostomy with accelerated pouch emptying. Conservative therapy includes diet changes, complementary pharmacotherapy and, if symptoms persist, surgical revision. Surgical options include endoscopic, endoluminal surgery to constrict the gastrojejunostomy using a novel endoscopic suturing device (OverStitch(TM), Apollo). In our study, we aimed to assess the viability, safety and efficacy of this procedure in patients with late dumping; 14 patients who had developed late dumping syndrome underwent surgery using an endoscopic suturing technique (OverStitch(TM), Apollo)...
August 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27313953/is-gastroparesis-found-more-frequently-in-patients-with-cystic-fibrosis-a-systematic-review
#18
REVIEW
Juan E Corral, Corey W Dye, Maria R Mascarenhas, Jamie S Barkin, Matthias Salathe, Baharak Moshiree
Cystic fibrosis (CF) is associated with different gastrointestinal motility disturbances and syndromes. We aim to assess gastric emptying in patients with CF compared to healthy controls by a systematic review of existing literature. Medical databases and abstracts from major gastroenterology and CF meetings were reviewed. Emptying times in CF patients were compared with healthy controls using random effects models. Subgroup analysis stratified results by age and diagnostic modality. Nineteen studies from 7 countries included 574 subjects (359 CF patients and 215 controls)...
2016: Scientifica
https://www.readbyqxmd.com/read/27239112/gastric-emptying-postprandial-blood-pressure-glycaemia-and-splanchnic-flow-in-parkinson-s-disease
#19
Laurence G Trahair, Thomas E Kimber, Katerina Flabouris, Michael Horowitz, Karen L Jones
AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects (13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease (Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq (99m)Tc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose by glucometer for 180 min...
May 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27197717/gastric-peroral-endoscopic-pyloromyotomy-g-poem-as-a-salvage-therapy-for-refractory-gastroparesis-a-case-series-of-different-subtypes
#20
P Mekaroonkamol, L Y Li, S Dacha, Y Xu, S D Keilin, F F Willingham, Q Cai
BACKGROUND: Gastroparesis is a poorly understood, chronic, debilitating motility disorder with very limited medical therapeutic options. Gastric peroral endoscopic pyloromyotomy (G-POEM) is an emerging novel endoscopic technique as an incisionless pyloroplasty for refractory cases. Effective information of G-POEM on different types of gastroparesis is sparse. METHODS: Cases of G-POEM using selective circular myotomy as a salvage therapy for refractory symptoms were retrospective studied...
August 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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