keyword
MENU ▼
Read by QxMD icon Read
search

mucosal barrier injury

keyword
https://www.readbyqxmd.com/read/27918411/potential-of-lactobacillus-plantarum-ccfm639-in-protecting-against-aluminum-toxicity-mediated-by-intestinal-barrier-function-and-oxidative-stress
#1
Leilei Yu, Qixiao Zhai, Fengwei Tian, Xiaoming Liu, Gang Wang, Jianxin Zhao, Hao Zhang, Arjan Narbad, Wei Chen
Aluminum (Al) is a ubiquitous metal that can seriously harm the health of animals and humans. In our previous study, we demonstrated that Lactobacillus plantarum CCFM639 can decrease Al burden in the tissues of mice by inhibiting intestinal Al absorption. The main aim of the present research was to investigate whether the protection by the strain is also associated with enhancement of the intestinal barrier, alleviation of oxidative stress and modulation of the inflammatory response. In an in vitro cell model, two protection modes (intervention and therapy) were examined and the results indicated that L...
December 2, 2016: Nutrients
https://www.readbyqxmd.com/read/27856070/impact-of-removing-mucosal-barrier-injury-laboratory-confirmed-bloodstream-infections-from-central-line-associated-bloodstream-infection-rates-in-the-national-healthcare-safety-network-2014
#2
Isaac See, Minn M Soe, Lauren Epstein, Jonathan R Edwards, Shelley S Magill, Nicola D Thompson
Central line-associated bloodstream infection (CLABSI) event data reported to the National Healthcare Safety Network from 2014, the first year of required use of the mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) definition, were analyzed to assess the impact of removing MBI-LCBI events from CLABSI rates. CLABSI rates decreased significantly in some location types after removing MBI-LCBI events, and MBI-LCBI events will be removed from publicly reported CLABSI rates.
November 14, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27827449/gata4-is-critical-to-maintain-gut-barrier-function-and-mucosal-integrity-following-epithelial-injury
#3
David Lepage, Élise Bélanger, Christine Jones, Sarah Tremblay, Joannie M Allaire, Joannie Bruneau, Claude Asselin, Nathalie Perreault, Alfredo Menendez, Fernand-Pierre Gendron, Francois Boudreau
The intestinal epithelial barrier is critical to limit potential harmful consequences from exposure to deleterious luminal contents on the organism. Although this barrier is functionally important along the entire gut, specific regional regulatory mechanisms involved in the maintenance of this barrier are poorly defined. Herein, we identified Gata4 as a crucial regulator of barrier integrity in the mouse proximal intestinal epithelium. Conditional deletion of Gata4 in the intestine led to a drastic increase in claudin-2 expression that was associated with an important increase of gut barrier permeability without causing overt spontaneous inflammation...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27760753/myosin-light-chain-kinase-mediates-intestinal-barrier-dysfunction-via-occludin-endocytosis-during-anoxia-reoxygenation-injury
#4
Younggeon Jin, Anthony T Blikslager
Intestinal anoxia/reoxygenation (A/R) injury induces loss of barrier function followed by epithelial repair. Myosin light chain kinase (MLCK) has been shown to alter barrier function via regulation of interepithelial tight junctions (TJ), but has not been studied in intestinal A/R injury. We hypothesized that A/R injury would disrupt TJ barrier function via MLCK activation and MLC phosphorylation. Caco-2BBe1 monolayers were subjected to anoxia for 2 hours followed by reoxygenation in 21% O2, after which barrier function was determined by measuring transepithelial resistance (TER) and FITC-dextran flux...
October 19, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27734759/the-effect-of-antioxidant-supplementation-on-bacterial-translocation-after-intestinal-ischemia-and-reperfusion
#5
A Tassopoulos, A Chalkias, A Papalois, N Iacovidou, T Xanthos
The intestine is highly sensitive to ischemia/reperfusion (I/R) injury. Intestinal I/R may cause local tissue injury and disruption of the intestinal mucosal barrier, allowing the passage of viable bacteria and endotoxins from the gastrointestinal lumen to distant organs. This phenomenon, known as bacterial translocation (BT), may lead to systemic disorders with high morbidity and mortality. Oxidative stress mediators such as reactive oxygen species, polymorphonuclear neutrophils and nitric oxide are believed to contribute to the intestinal I/R injury...
January 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27707514/non-redundant-role-of-the-chemokine-receptor-cx3cr1-in-the-anti-inflammatory-function-of-gut-macrophages
#6
G Marelli, C Belgiovine, A Mantovani, M Erreni, P Allavena
Mucosal immunity at the intestinal level is constantly challenged by the presence of external food and microbial antigens and must be kept under strict control to avoid the rise of aberrant inflammation. Among cells of the innate immunity, macrophages expressing the chemokine receptor CX3CR1 are strategically located near the gut epithelial barrier. These cells contribute to the maintenance of homeostasis by producing the anti-inflammatory cytokine IL-10; however, their role in the control of full blown inflammation and tissue injury is controversial...
August 2, 2016: Immunobiology
https://www.readbyqxmd.com/read/27632432/stable-isotope-techniques-for-the-assessment-of-host-and-microbiota-response-during-gastrointestinal-dysfunction
#7
Ross N Butler, Margaret Kosek, Nancy F Krebs, Cornelia U Loechl, Alexander Loy, Victor O Owino, Michael B Zimmermann, Douglas J Morrison
The International Atomic Energy Agency convened a technical meeting on environmental enteric dysfunction (EED) in Vienna (28-30 October 2015; https://nucleus.iaea.org/HHW/Nutrition/EED_Technical_Meeting/index.html) to bring together international experts in the fields of EED, nutrition and stable isotope technologies. Advances in stable isotope labelling techniques open up new possibilities to improve our understanding of gastrointestinal dysfunction and the role of the microbiota in host health. In the context of EED, little is known about the role gut dysfunction may play in macro- and micronutrient bioavailability and requirements and what the consequences may be for nutritional status and linear growth...
September 14, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27609629/clabsi-risk-factors-in-the-nicu-potential-for-prevention-a-picnic-study
#8
Maya Dahan, Shauna O'Donnell, Julie Hebert, Milagros Gonzales, Bonita Lee, A Uma Chandran, Samantha Woolsey, Sandra Escoredo, Heather Chinnery, Caroline Quach
OBJECTIVE Central-line-associated bloodstream infections (CLABSI) are an important cause of morbidity and mortality in neonates. We aimed to determine whether intra-abdominal pathologies are an independent risk factor for CLABSI. METHODS We performed a retrospective matched case-control study of infants admitted to the neonatal intensive care units (NICUs) of the Montreal Children's Hospital (Montreal) and the Royal Alexandra Hospital, Edmonton, Canada. CLABSI cases that occurred between April 2009 and March 2014 were identified through local infection control databases...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27594973/genome-wide-transcriptional-analysis-reveals-the-protection-against-hypoxia-induced-oxidative-injury-in-the-intestine-of-tibetans-via-the-inhibition-of-grb2-egfr-ptpn11-pathways
#9
Kang Li, Luobu Gesang, Zeng Dan, Lamu Gusang
The molecular mechanisms for hypoxic environment causing the injury of intestinal mucosal barrier (IMB) are widely unknown. To address the issue, Han Chinese from 100 m altitude and Tibetans from high altitude (more than 3650 m) were recruited. Histological and transcriptome analyses were performed. The results showed intestinal villi were reduced and appeared irregular, and glandular epithelium was destroyed in the IMB of Tibetans when compared with Han Chinese. Transcriptome analysis revealed 2573 genes with altered expression...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27590778/-candiduria-what-now-therapy-of-urinary-tract-infections-with-candida
#10
H Hof
BACKGROUND: Yeasts are found in urine specimens relatively often, especially in the elderly and patients under treatment with broad spectrum antibiotics, i. e. especially in intensive care unit (ICU) patients. In some cases, the number of pathogens is very high, i. e. >10(5)/ml. The clinical relevance of detecting Candida in urine is difficult to assess. In the German S3 guidelines it is apodictically stated that an ascending infection of the urinary tract by yeasts does not occur but this may undoubtedly happen in certain instances in patients at risk, for example in the elderly, in diabetic persons and in the case of foreign bodies in the urinary tract...
September 2, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27588102/probiotic-pre-administration-reduces-mortality-in-a-mouse-model-of-cecal-ligation-and-puncture-induced-sepsis
#11
Lufang Chen, Keying Xu, Qifeng Gui, Yue Chen, Deying Chen, Yunmei Yang
A number of clinical trials have demonstrated that the use of probiotics has the potential to prevent nosocomial infections. However, the mechanism underlying probiotic-induced anti-infection and sepsis remains to be investigated. In the present study, 200 µl/day of Lactobacillus rhamnosus GG (LGG) or normal saline (control) was orally administrated to 4-week-old C57BL6 mice 4 weeks prior to cecal ligation and puncture (CLP). A number of mice were sacrificed 24 h after CLP, and the remaining mice were used for survival studies...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27588057/glutamine-decreases-intestinal-mucosal-injury-in-a-rat-model-of-intestinal-ischemia-reperfusion-by-downregulating-hmgb1-and-inflammatory-cytokine-expression
#12
Xiaoliang Shu, Jian Zhang, Qingxiu Wang, Zengguang Xu, Tingting Yu
Intestinal ischemia-reperfusion (IR) is a common clinical pathophysiological process that is common in severe trauma, major surgery, and in post-resuscitation. Glutamine (Gln) reduces intestinal IR injury, however, its mechanism of action remains to be determined. High mobility group box 1 (HMGB1) protein, nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-1 (IL-1) are mediators involved in the pathophysiology of intestinal IR injury. The aim of the present study was to investigate the effects of Gln on the intestinal mucosa of HMGB1 expression following IR to determine whether Gln relieved intestinal IR injury in the intestinal mucosal barrier...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27578924/when-insult-is-added-to-injury-cross-talk-between-ilcs-and-intestinal-epithelium-in-ibd
#13
REVIEW
Esmé van der Gracht, Sonja Zahner, Mitchell Kronenberg
Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27573037/severity-of-pancreatitis%C3%A2-associated-intestinal-mucosal-barrier-injury-is-reduced-following-treatment-with-the-nadph-oxidase-inhibitor-apocynin
#14
Wenhong Deng, Ablikim Abliz, Sheng Xu, Rongze Sun, Wenyi Guo, Qiao Shi, Jia Yu, Weixing Wang
Recent studies demonstrated that apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor, significantly decreased acute pancreatitis‑associated inflammatory and oxidative stress parameters. In addition, apocynin was able to reduce ischemic reperfusion injury‑associated damage; however, the exact effects of apocynin on acute pancreatitis‑associated intestinal mucosal injury have yet to be fully clarified. The present study aimed to investigate the protective effects of apocynin on intestinal mucosal injury in a rat model of severe acute pancreatitis (SAP)...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27553226/deposition-of-microparticles-by-neutrophils-onto-inflamed-epithelium-a-new-mechanism-to-disrupt-epithelial-intercellular-adhesions-and-promote-transepithelial-migration
#15
Veronika Butin-Israeli, Madelyn C Houser, Mingli Feng, Edward B Thorp, Asma Nusrat, Charles A Parkos, Ronen Sumagin
Neutrophil [polymorphonuclear leukocyte (PMN)] transepithelial migration (TEM) is a hallmark of inflammatory mucosal disorders. PMN TEM is associated with epithelial injury; however, mechanisms involved in this process are not well defined. The current work describes a new mechanism whereby deposition of PMN membrane-derived microparticles (PMN-MPs) onto intestinal epithelial cells (IECs) during TEM leads to loss of epithelial cadherins, thus promoting epithelial injury and increased PMN recruitment. PMN-MPs secreted by activated PMNs during TEM displayed a high level of enzymatically active matrix metalloproteinase 9 (MMP-9), and were capable of mediating potent effects on IEC integrity...
December 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27506986/berberine-reduces-uremia-associated-intestinal-mucosal-barrier-damage
#16
Chao Yu, Shanjun Tan, Chunyu Zhou, Cuilin Zhu, Xin Kang, Shuai Liu, Shuang Zhao, Shulin Fan, Zhen Yu, Ai Peng, Zhen Wang
Berberine is one of the main active constituents of Rhizoma coptidis, a traditional Chinese medicine, and has long been used for the treatment of gastrointestinal disorders. The present study was designed to investigate the effects of berberine on the intestinal mucosal barrier damage in a rat uremia model induced by the 5/6 kidney resection. Beginning at postoperative week 4, the uremia rats were treated with daily 150 mg/kg berberine by oral gavage for 6 weeks. To assess the intestinal mucosal barrier changes, blood samples were collected for measuring the serum D-lactate level, and terminal ileum tissue samples were used for analyses of intestinal permeability, myeloperoxidase activity, histopathology, malondialdehyde (MDA) level, and superoxide dismutase (SOD) activity...
August 9, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27493661/chronic-kidney-disease-induced-intestinal-mucosal-barrier-damage-associated-with-intestinal-oxidative-stress-injury
#17
Chao Yu, Zhen Wang, Shanjun Tan, Qiang Wang, Chunyu Zhou, Xin Kang, Shuang Zhao, Shuai Liu, Huijun Fu, Zhen Yu, Ai Peng
Background. To investigate whether intestinal mucosal barrier was damaged or not in chronic kidney disease progression and the status of oxidative stress. Methods. Rats were randomized into two groups: a control group and a uremia group. The uremia rat model was induced by 5/6 kidney resection. In postoperative weeks (POW) 4, 6, 8, and 10, eight rats were randomly selected from each group to prepare samples for assessing systemic inflammation, intestinal mucosal barrier changes, and the status of intestinal oxidative stress...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27431777/the-glucocorticoid-budesonide-has-protective-and-deleterious-effects-in-experimental-colitis-in-mice
#18
Borja Ocón, Carlos J Aranda, Reyes Gámez-Belmonte, María Dolores Suárez, Antonio Zarzuelo, Olga Martínez-Augustin, Fermín Sánchez de Medina
Glucocorticoids are widely used for the management of inflammatory bowel disease, albeit with known limitations for long-term use and relevant adverse effects. In turn, they have harmful effects in experimental colitis. We aimed to explore the mechanism and possible implications of this phenomenon. Regular and microbiota depleted C57BL/6 mice were exposed to dextran sulfate sodium (DSS) to induce colitis and treated with budesonide. Colonic inflammation and animal status were compared. In vitro epithelial models of wound healing were used to confirm the effects of glucocorticoids...
September 15, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27411459/effect-of-candida-albicans-on-intestinal-ischemia-reperfusion-injury-in-rats
#19
Lei Yan, Chun-Rong Wu, Chen Wang, Chun-Hui Yang, Guang-Zhi Tong, Jian-Guo Tang
BACKGROUND: Inflammation is supposed to play a key role in the pathophysiological processes of intestinal ischemia-reperfusion injury (IIRI), and Candida albicans in human gut commonly elevates inflammatory cytokines in intestinal mucosa. This study aimed to explore the effect of C. albicans on IIRI. METHODS: Fifty female Wistar rats were divided into five groups according to the status of C. albicans infection and IIRI operation: group blank and sham; group blank and IIRI; group cefoperazone plus IIRI; group C...
July 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27353251/nlrp6-function-in-inflammatory-monocytes-reduces-susceptibility-to-chemically-induced-intestinal-injury
#20
S S Seregin, N Golovchenko, B Schaf, J Chen, K A Eaton, G Y Chen
NLRP6 is a member of the Nod-like receptor family, whose members are involved in the recognition of microbes and/or tissue injury. NLRP6 was previously demonstrated to regulate the production of interleukin (IL)-18 and is important for protecting mice against chemically induced intestinal injury and colitis-associated colon cancer. However, the cellular mechanisms by which NLRP6 reduces susceptibility to colonic inflammation remain unclear. Here, we determined that NLRP6 expression is specifically upregulated in Ly6C(hi) inflammatory monocytes that infiltrate into the colon during dextran sulfate sodium (DSS)-induced inflammation...
June 29, 2016: Mucosal Immunology
keyword
keyword
69834
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"