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https://www.readbyqxmd.com/read/28340346/the-upsides-and-downsides-of-organelle-interconnectivity
#1
REVIEW
Daniel E Gottschling, Thomas Nyström
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28339410/unimanual-versus-bimanual-therapy-in-children-with-unilateral-cerebral-palsy-same-same-but-different
#2
Brian Hoare, Susan Greaves
BACKGROUND: There is high-level evidence supporting constraint-induced movement therapy (CIMT) and bimanual therapy for children with unilateral cerebral palsy. Evidence-based intervention includes time-limited, goal-directed, skills-based, intensive blocks of practice based on motor learning theory. AIM AND METHODS: Using supporting literature and clinical insight, we provide a theoretical rationale to highlight previously unreported differences between CIMT and bimanual therapy...
2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/28338290/identification-of-natural-inhibitors-of-bcr-abl-for-the-treatment-of-chronic-myeloid-leukemia
#3
Phani Krishna, Sailu Sarvagalla, Bindu Madhuri, Sankar Pajaniradje, Vinitha Baskaran, Mohane Selvaraj Coumar, R Baskaran
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells, characterized at the molecular level by the bcr/abl gene rearrangement. Even though targeting the fusion gene product Bcr-Abl protein is a successful strategy, development of drug resistance and drug intolerance are currently the limitations for Bcr-Abl targeted CML therapy. With an aim to develop natural Bcr-Abl inhibitors, we performed virtual screening (VS) of ZINC natural compound database by docking with Abl kinase using Glide software...
March 24, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28338233/unraveling-the-roles-of-orienting-and-inhibition-in-the-concealed-information-test
#4
Nathalie Klein Selle, Bruno Verschuere, Merel Kindt, Ewout Meijer, Gershon Ben-Shakhar
The Concealed Information Test (CIT) is a well-validated tool for physiological and behavioral detection of concealed knowledge. Two distinct theoretical frameworks have been proposed to explain the differential responses to the concealed critical items: orienting response theory versus arousal inhibition theory. klein Selle, Verschuere, Kindt, Meijer, and Ben-Shakhar (2016), however, argued for a response fractionation model and showed that, while the skin conductance reflects pure orienting, both the respiratory and heart rate measures reflect arousal inhibition...
April 2017: Psychophysiology
https://www.readbyqxmd.com/read/28338151/field-theoretic-simulations-of-random-copolymers-with-structural-rigidity
#5
Shifan Mao, Quinn MacPherson, Jian Qin, Andrew J Spakowitz
Copolymers play an important role in a range of soft-materials applications and biological phenomena. Prevalent works on block copolymer phase behavior use flexible chain models and incorporate interactions using a mean-field approximation. However, when phase separation takes place on length scales comparable to a few monomers, the structural rigidity of the monomers becomes important. In addition, concentration fluctuations become significant at short length scales, rendering the mean-field approximation invalid...
March 24, 2017: Soft Matter
https://www.readbyqxmd.com/read/28337430/improving-access-to-use-of-and-outcomes-from-public-health-programs-the-importance-of-building-and-maintaining-trust-with-patients-clients
#6
REVIEW
Paul Russell Ward
The central argument in this paper is that "public trust" is critical for developing and maintaining the health and wellbeing of individuals, communities, and societies. I argue that public health practitioners and policy makers need to take "public trust" seriously if they intend to improve both the public's health and the engagement between members of the public and public health systems. Public health practitioners implement a range of services and interventions aimed at improving health but implicit a requirement for individuals to trust the practitioners and the services/interventions, before they engage with them...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28335678/computational-study-on-transfer-of-l-ascorbic-acid-by-ulaa-through-escherichia-coli-membrane
#7
Ehsan Faghih-Mirzaee, Maryam Dehestani, Leila Zeidabadinejad
In this study, the transfer of L-ascorbic acid by UlaA through Escherichia coli (E. coli) membrane was evaluated using density functional theory (DFT), molecular docking, and molecular dynamics (MD) simulation methods. DFT calculations at the B3lyp/6[Formula: see text]311[Formula: see text]G(p,d) level were performed to investigate the interaction properties and molecular descriptors. The physical properties, such as chemical potential, chemical hardness, and chemical electrophilicity of all studied molecules, were investigated...
February 24, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28334943/effects-of-prefrontal-cortex-damage-on-emotion-understanding-eeg-and-behavioural-evidence
#8
Anat Perry, Samantha N Saunders, Jennifer Stiso, Callum Dewar, Jamie Lubell, Torstein R Meling, Anne-Kristin Solbakk, Tor Endestad, Robert T Knight
Humans are highly social beings that interact with each other on a daily basis. In these complex interactions, we get along by being able to identify others' actions and infer their intentions, thoughts and feelings. One of the major theories accounting for this critical ability assumes that the understanding of social signals is based on a primordial tendency to simulate observed actions by activating a mirror neuron system. If mirror neuron regions are important for action and emotion recognition, damage to regions in this network should lead to deficits in these domains...
February 22, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334005/multi-scale-model-of-drug-induced-adaptive-resistance-of-gram-negative-bacteria-to-polymyxin-b
#9
Wojciech Krzyzanski, Gauri G Rao
The purpose of this report is to apply multi-scale modeling using the theory of physiologically structured populations (PSP) to develop a mathematical model for antimicrobial resistance based on a heterogeneous distribution of receptors and affinities among bacterial cells. The theory has been tested on data obtained from an in vitro static time-kill infection model analyzing the pharmacodynamics of polymyxin B against Gram-negative bacteria. The drug binding parameter KD (dissociation equilibrium constant) is assumed to vary between the bacterial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28333686/abnormal-nonlocal-scale-effect-on-the-static-bending-of-single-layer-mos2
#10
Ming-Lin Li, Haili Huang, Liping Tu, Weidong Wang, Peifeng Li, Yang Lu
The nonlocal scale parameter of the nonlocal Euler-Bernoulli beam theory is evaluated for the static bending of single layer molybdenum disulfide (SLMoS2) without the predetermined bending rigidity. The evaluation activity is performed by matching the fitted curve between the maximum deflection and the beam length obtained from molecular mechanics simulations. It was observed that the fitted curves have an abnormal sign in the second order term of the maximum deflection for SLMoS2, opposite to that for graphene and regardless of the used interatomic interaction potentials...
March 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28333589/a-unified-theory-of-neuro-mri-data-shows-scale-free-nature-of-connectivity-modes
#11
Vitaly L Galinsky, Lawrence R Frank
A primary goal of many neuroimaging studies that use magnetic resonance imaging (MRI) is to deduce the structure-function relationships in the human brain using data from the three major neuro-MRI modalities: high-resolution anatomical, diffusion tensor imaging, and functional MRI. To date, the general procedure for analyzing these data is to combine the results derived independently from each of these modalities. In this article, we develop a new theoretical and computational approach for combining these different MRI modalities into a powerful and versatile framework that combines our recently developed methods for morphological shape analysis and segmentation, simultaneous local diffusion estimation and global tractography, and nonlinear and nongaussian spatial-temporal activation pattern classification and ranking, as well as our fast and accurate approach for nonlinear registration between modalities...
March 23, 2017: Neural Computation
https://www.readbyqxmd.com/read/28333497/not-all-nonnormal-distributions-are-created-equal-improved-theoretical-and-measurement-precision
#12
Harry Joo, Herman Aguinis, Kyle J Bradley
We offer a four-category taxonomy of individual output distributions (i.e., distributions of cumulative results): (1) pure power law; (2) lognormal; (3) exponential tail (including exponential and power law with an exponential cutoff); and (4) symmetric or potentially symmetric (including normal, Poisson, and Weibull). The four categories are uniquely associated with mutually exclusive generative mechanisms: self-organized criticality, proportionate differentiation, incremental differentiation, and homogenization...
March 23, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28333493/bayesian-approaches-to-autism-towards-volatility-action-and-behavior
#13
Colin J Palmer, Rebecca P Lawson, Jakob Hohwy
Autism spectrum disorder currently lacks an explanation that bridges cognitive, computational, and neural domains. In the past 5 years, progress has been sought in this area by drawing on Bayesian probability theory to describe both social and nonsocial aspects of autism in terms of systematic differences in the processing of sensory information in the brain. The present article begins by synthesizing the existing literature in this regard, including an introduction to the topic for unfamiliar readers. The key proposal is that autism is characterized by a greater weighting of sensory information in updating probabilistic representations of the environment...
March 23, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28332869/perceived-enjoyment-concentration-intention-and-speed-violation-behavior-using-flow-theory-and-theory-of-planned-behavior
#14
Charles Atombo, Chaozhong Wu, Hui Zhang, Tina D Wemegah
OBJECTIVE: Road accidents are an important public health concern and speeding is a major contributor. Although, flow theory (FLT) is a valid model for understanding behavior, currently the nature of the roles and interplay, of FLT constructs within the theory of planned behavior (TPB) framework when attempting to explain the determinants of motivations for intention to speed and speeding behavior of car drivers is not yet known. The study aims to synthesize TPB and FLT in explaining drivers of advanced vehicles intention to speed and speed violation behavior and evaluate factors which are critical for explaining intention and behavior...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28332691/relaxations-and-phase-transitions-during-the-collapse-of-a-dense-pnipam-microgel-suspension-thorough-insight-using-dielectric-spectroscopy
#15
Man Yang, Chunyan Liu, Yiwei Lian, Kongshuang Zhao, Dan Zhu, Jianfeng Zhou
The dielectric behavior of a thermo-sensitive poly-(N-isopropylacrylamide) (PNIPAM) microgel suspension with a dense concentration was investigated over the frequency range of 40 Hz to 110 MHz in a wide temperature window of 10-60 °C. By successfully removing the electrode polarization effect from the original data, two remarkable and temperature-dependent relaxation processes were observed. Both of the two-phase transition processes, i.e., the colloidal crystal-to-liquid transition, which has not yet been detected by dielectric spectroscopy before, as well as the volume phase transition, were detected by the relaxation parameters...
March 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28330486/relationships-between-structure-process-and-outcome-to-assess-quality-of-integrated-chronic-disease-management-in-a-rural-south-african-setting-applying-a-structural-equation-model
#16
Soter Ameh, Francesc Xavier Gómez-Olivé, Kathleen Kahn, Stephen M Tollman, Kerstin Klipstein-Grobusch
BACKGROUND: South Africa faces a complex dual burden of chronic communicable and non-communicable diseases (NCDs). In response, the Integrated Chronic Disease Management (ICDM) model was initiated in primary health care (PHC) facilities in 2011 to leverage the HIV/ART programme to scale-up services for NCDs, achieve optimal patient health outcomes and improve the quality of medical care. However, little is known about the quality of care in the ICDM model. The objectives of this study were to: i) assess patients' and operational managers' satisfaction with the dimensions of ICDM services; and ii) evaluate the quality of care in the ICDM model using Avedis Donabedian's theory of relationships between structure (resources), process (clinical activities) and outcome (desired result of healthcare) constructs as a measure of quality of care...
March 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28327622/continuously-varying-critical-exponents-beyond-weak-universality
#17
N Khan, P Sarkar, A Midya, P Mandal, P K Mohanty
Renormalization group theory does not restrict the form of continuous variation of critical exponents which occurs in presence of a marginal operator. However, the continuous variation of critical exponents, observed in different contexts, usually follows a weak universality scenario where some of the exponents (e.g., β, γ, ν) vary keeping others (e.g., δ, η) fixed. Here we report ferromagnetic phase transition in (Sm1-yNdy)0.52Sr0.48MnO3 (0.5 ≤ y ≤ 1) single crystals where all three exponents β, γ, δ vary with Nd concentration y...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327243/what-does-evolutionary-theory-add-to-stereotype-theory-in-the-explanation-of-attractiveness-bias
#18
Kirby Q Maguire, Timothy P Racine
Maestripieri et al. seem to put forth an argument in which they become vulnerable to some of the same criticisms that they level against stereotype theory As a result, the explanatory utility of their account of attractiveness bias comes into question, and it is unclear whether it offers anything superior to stereotype theory in conceptual soundness.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327147/medical-student-changes-in-self-regulated-learning-during-the-transition-to-the-clinical-environment
#19
Kenneth K Cho, Brahm Marjadi, Vicki Langendyk, Wendy Hu
BACKGROUND: Self-regulated learning (SRL), which is learners' ability to proactively select and use different strategies to reach learning goals, is associated with academic and clinical success and life-long learning. SRL does not develop automatically in the clinical environment and its development during the preclinical to clinical learning transition has not been quantitatively studied. Our study aims to fill this gap by measuring SRL in medical students during the transitional period and examining its contributing factors...
March 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28326538/integrating-lipid-storage-into-general-representations-of-fish-energetics
#20
Benjamin T Martin, Ron Heintz, Eric M Danner, Roger M Nisbet
1.Fish, even of the same species, can exhibit substantial variation in energy density (energy per unit wet weight). Most of this variation is due to differences in the amount of storage lipids. In addition to their importance as energy reserves for reproduction and for survival during unfavorable conditions, the accumulation of lipids represents a large energetic flux for many species, so figuring out how this energy flux is integrated with other major energy fluxes (growth, reproduction) is critical for any general theory of organismal energetics...
March 22, 2017: Journal of Animal Ecology
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