keyword
MENU ▼
Read by QxMD icon Read
search

Clearance of apoptotic cells

keyword
https://www.readbyqxmd.com/read/29324974/the-role-of-endoplasmic-reticulum-aminopeptidase-2-erap2-in-modulating-immune-detection-of-choriocarcinoma
#1
Michelle D Warthan, Sonya L Washington, Samone E Franzese, Ronald M Ramus, Kyu-Rae Kim, Timothy P York, Efstratios Stratikos, Jerome F Strauss, Eun D Lee
Gestational choriocarcinomas are derived from placental trophoblast cells, with HLA-C being the only class I polymorphic molecule expressed. However, choriocarcinomas have not been profiled for endoplasmic reticulum aminopeptidase 2 (ERAP2) expression. ERAP2 trims peptides presented by human leukocyte antigens (HLA) have shown to modulate immune response. Over 50% of choriocacinomas we screened lack ERAP2 expression, which suggests the absence of ERAP2 expression allows immune evasion of choriocarcinoma cells...
January 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29320819/molecular-and-biochemical-characterization-of-opisthorchis-viverrini-calreticulin
#2
Wanlapa Chaibangyang, Amornrat Geadkaew-Krenc, Suksiri Vichasri-Grams, Smarn Tesana, Rudi Grams
Calreticulin (CALR), a multifunctional protein thoroughly researched in mammals, comprises N-, P-, and C-domain and has roles in calcium homeostasis, chaperoning, clearance of apoptotic cells, cell adhesion, and also angiogenesis. In this study, the spatial and temporal expression patterns of the Opisthorchis viverrini CALR gene were analyzed, and calcium-binding and chaperoning properties of recombinant O. viverrini CALR (OvCALR) investigated. OvCALR mRNA was detected from the newly excysted juvenile to the mature parasite by RT-PCR while specific antibodies showed a wide distribution of the protein...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29315209/the-bioactive-extract-of-pinnigorgia-sp-induces-apoptosis-of-hepatic-stellate-cells-via-ros-erk-jnk-caspase-3-signaling
#3
Liang-Mou Kuo, Po-Jen Chen, Ping-Jyun Sung, Yu-Chia Chang, Chun-Ting Ho, Yi-Hsiu Wu, Tsong-Long Hwang
The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viability of HSC-T6 cells and increased their subG1 population, DNA fragmentation, caspase-3 activation, and reactive oxygen species (ROS) production in a concentration-dependent manner. The Pin-induced ROS generation and apoptotic effects were significantly reversed by a thiol antioxidant, N-acetylcysteine (NAC)...
January 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29305520/soluble-slamf6-receptor-induces-strong-cd8-t-cell-effector-function-and-improves-anti-melanoma-activity-in-vivo
#4
Galit Eisenberg, Roni Engelstein, Anat Geiger, Emma Hajaj, Sharon Merims, Shoshana Frankenburg, Ronny Uzana, Abraham Rutenberg, Arthur Machlenkin, Gabi Frei, Tamar Peretz, Michal Lotem
SLAMF6, a member of the SLAM (signaling lymphocyte activation molecules) family, is a homotypic-binding immune receptor expressed on NK, T, and B lymphocytes. Phosphorylation variance between T-cell subclones prompted us to explore its role in anti-melanoma immunity. Using a 203-amino acid sequence of the human SLAMF6 (seSLAMF6) ectodomain, we found that seSLAMF6 reduced activation-induced cell death and had an anti-apoptotic effect on tumor infiltrating lymphocytes. CD8+ T cells costimulated with seSLAMF6 secreted more interferon gamma and displayed augmented cytolytic activity...
January 5, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29304470/protein-s-and-gas6-induce-efferocytosis-of-hiv-1-infected-cells
#5
Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ, Christina M Ramirez, Haruko Nakano, Kouki Morizono
Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular mechanisms are unknown. To elucidate the roles that efferocytosis of HIV-1-infected cells play in clearance of infected cells, we sought to identify molecules that mediate these processes. We found that protein S, present in human serum, and its homologue, Gas6, can mediate phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer, expressed on macrophages, to phosphatidylserine exposed on infected cells...
January 2, 2018: Virology
https://www.readbyqxmd.com/read/29278672/the-initiation-of-autoimmunity-at-epithelial-surfaces-a-focus-on-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#6
Peta Pentony, Laurence Duquenne, Katherine Dutton, Kulveer Mankia, Hanna Gul, Edward Vital, Paul Emery
It is well established that the autoantibodies that characterize both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are present systemically years before patients develop disease. In both these autoimmune rheumatic diseases, evidence is growing that local autoimmune processes occur at epithelial surfaces potentially initiating localized autoimmunity. For RA, these are mucosal surfaces including the oral mucosa, lung, and gut. At the oral mucosa and lung, risk factors such as periodontal disease and smoking may contribute to autoimmunity by driving the local generation of citrullinated autoantigens...
November 2017: Discovery Medicine
https://www.readbyqxmd.com/read/29259271/clearance-of-a-persistent-picornavirus-infection-is-associated-with-enhanced-pro-apoptotic-and-cellular-immune-responses
#7
Carolina Stenfeldt, Michael Eschbaumer, George R Smoliga, Luis L Rodriguez, James Zhu, Jonathan Arzt
Long-term persistent viral infections cause substantial morbidity and associated economic losses in human and veterinary contexts. Yet, the mechanisms associated with establishment of persistent infections are poorly elucidated. We investigated immunomodulatory mechanisms associated with clearance versus persistence of foot-and-mouth disease virus (FMDV) in micro-dissected compartments of the bovine nasopharynx by microarray. The use of laser-capture microdissection allowed elucidation of differential gene regulation within distinct anatomic compartments critical to FMDV infection...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247774/regulation-of-microglia-identity-from-an-epigenetic-and-transcriptomic-point-of-view
#8
Bart Jl Eggen, Erik Wgm Boddeke, Susanne M Kooistra
Microglia have long been recognized as the endogenous innate immune elements in the central nervous system (CNS) parenchyma. Besides fulfilling local immune related functions, they provide cross-talk between the CNS and the immune system at large. In the adult CNS, microglia are involved in maintaining brain homeostasis, modulating synaptic transmission and clearance of apoptotic cells. During embryonic development, microglia are responsible for the removal of supernumerary synapses and neurons, and neuronal network formation...
December 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/29247646/incomplete-clearance-of-apoptotic-cells-by-core-1-derived-o-glycan-deficient-resident-peritoneal-macrophages
#9
Hiromasa Wakui, Sayaka Fuseya, Riku Suzuki, Miki Shimbo, Risa Okada, Mitchito Hamada, Akihiro Kuno, Kozue Hagiwara, Takashi Sato, Hisashi Narimatsu, Takashi Kudo, Satoru Takahashi
The core 1 β1,3-galactosyltransferase-specific molecular chaperon (Cosmc) is essential for the synthesis of the core 1 structure of mucin-type O-glycans. To clarify the physiological role of core 1-derived O-glycans in macrophages, we exploited the LysM-Cre transgene to generate a conditional Cosmc mutant allele (conditional Cosmc knockout; cKO) in myeloid cells. cKO mice developed normally with no gross phenotypic abnormalities or abnormal peripheral blood counts. Resident peritoneal macrophages (rpMacs) of cKO mice exhibited impaired engulfment of apoptotic cells but showed normal macrophage differentiation and counts...
December 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29238344/scrambled-eggs-apoptotic-cell-clearance-by-non-professional-phagocytes-in-the-drosophila-ovary
#10
REVIEW
Sandy B Serizier, Kimberly McCall
For half of a century, it has been known that non-professional phagocytes, such as fibroblasts, endothelial, and epithelial cells, are capable of efferocytosis (engulfment of apoptotic cells). Non-professional phagocytes differ from professional phagocytes in the range and efficiency of engulfment. Much of the recognition and underlying signaling machinery between non-professional and professional phagocytes is the same, but it is not known how the engulfment capacity of non-professional phagocytes is controlled...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29233884/revisiting-multimodal-activation-and-channel-properties-of-pannexin-1
#11
REVIEW
Yu-Hsin Chiu, Michael S Schappe, Bimal N Desai, Douglas A Bayliss
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have been implicated in diverse physiological and pathological functions associated with purinergic signaling, such as apoptotic cell clearance, blood pressure regulation, neuropathic pain, and excitotoxicity. In light of this, substantial attention has been directed to understanding the mechanisms that regulate Panx1 channel expression and activation...
December 12, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29229994/autophagy-induced-during-apoptosis-degrades-mitochondria-and-inhibits-type-i-interferon-secretion
#12
Lisa M Lindqvist, Daniel Frank, Kate McArthur, Toby A Dite, Michael Lazarou, Jonathan S Oakhill, Benjamin T Kile, David L Vaux
Cells undergoing Bax/Bak-mediated apoptosis exhibit signs of autophagy, but how it is activated and its significance is unknown. By directly activating Bax/Bak with BH3-only proteins or BH3 mimetic compounds, we demonstrate that mitochondrial damage correlated with a rapid increase in intracellular [AMP]/[ATP], phosphorylation of 5' AMP-activated protein kinase (AMPK), and activation of unc-51 like autophagy activating kinase 1 (ULK1). Consequently, autophagic flux was triggered early in the apoptotic pathway, as activation of the apoptosome and caspases were not necessary for its induction...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29209316/complement-protein-c1q-binds-to-hyaluronic-acid-in-the-malignant-pleural-mesothelioma-microenvironment-and-promotes-tumor-growth
#13
Chiara Agostinis, Romana Vidergar, Beatrice Belmonte, Alessandro Mangogna, Leonardo Amadio, Pietro Geri, Violetta Borelli, Fabrizio Zanconati, Francesco Tedesco, Marco Confalonieri, Claudio Tripodo, Uday Kishore, Roberta Bulla
C1q is the first recognition subcomponent of the complement classical pathway, which acts toward the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, and has been shown to be involved in placental development and sensorial synaptic pruning. We have recently shown that C1q can promote tumor by encouraging their adhesion, migration, and proliferation in addition to angiogenesis and metastasis. In this study, we have examined the role of human C1q in the microenvironment of malignant pleural mesothelioma (MPM), a rare form of cancer commonly associated with exposure to asbestos...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29202471/apoptosis-induced-cxcl5-accelerates-inflammation-and-growth-of-prostate-tumor-metastases-in-bone
#14
Hernan Roca, Jacqueline D Jones, Marta C Purica, Savannah Weidner, Amy J Koh, Robert Kuo, John E Wilkinson, Yugang Wang, Stephanie Daignault-Newton, Kenneth J Pienta, Todd M Morgan, Evan T Keller, Jacques E Nör, Lonnie D Shea, Laurie K McCauley
During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of efferocytosis in metastatic tumor growth is unknown. In this study, we observed that macrophage-driven efferocytosis of prostate cancer cells in vitro induced the expression of proinflammatory cytokines such as CXCL5 by activating Stat3 and NF-κB(p65) signaling. Administration of a dimerizer ligand (AP20187) triggered apoptosis in 2 in vivo syngeneic models of bone tumor growth in which apoptosis-inducible prostate cancer cells were either coimplanted with vertebral bodies, or inoculated in the tibiae of immunocompetent mice...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29196891/sodium-valproate-modulates-immune-response-by-alternative-activation-of-monocyte-derived-macrophages-in-systemic-lupus-erythematosus
#15
Saeed Mohammadi, Marie Saghaeian-Jazi, Sima Sedighi, Ali Memarian
The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to enhance the expansion of M2 macrophages. Sodium valproate (VPA) is an HDACi with different anti-inflammatory properties. Here, we aimed to investigate the effects of HDACi by VPA on the polarization of monocyte-derived macrophages (MDMs) and regulating the expression of anti-inflammatory cytokines in SLE...
December 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29186811/ascorbic-acid-attenuates-senescence-of-human-osteoarthritic-osteoblasts
#16
Maximilian G Burger, Amir Steinitz, Jeroen Geurts, Benjamin E Pippenger, Dirk J Schaefer, Ivan Martin, Andrea Barbero, Karoliina Pelttari
The accumulation of senescent cells is implicated in the pathology of several age-related diseases. While the clearance of senescent cells has been suggested as a therapeutic target for patients with osteoarthritis (OA), cellular senescence of bone-resident osteoblasts (OB) remains poorly explored. Since oxidative stress is a well-known inducer of cellular senescence, we here investigated the effect of antioxidant supplementation on the isolation efficiency, expansion, differentiation potential, and transcriptomic profile of OB from osteoarthritic subchondral bone...
November 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29177124/harnessing-apoptotic-cells-for-transplantation-tolerance-current-status-and-future-perspectives
#17
Anil Dangi, Xunrong Luo
Purpose of review: The use of donor apoptotic cells is an emerging therapy for inducing transplantation tolerance. In this review, we will discuss current understanding of mechanisms of this approach, as well as crucial aspects necessary for successful translation of this approach to clinical transplantation. Recent findings: Transplantation tolerance by donor apoptotic cells is mediated by their homeostatic interaction with recipient phagocytes, and subsequent expansion of suppressor cell populations as well as inhibition of effector T cells via deletion and anergy...
December 2017: Current Transplantation Reports
https://www.readbyqxmd.com/read/29176978/requirement-of-gamma-carboxyglutamic-acid-modification-and-phosphatidylserine-binding-for-the-activation-of-tyro3-axl-and-mertk-receptors-by-growth-arrest-specific-6
#18
Ke Geng, Sushil Kumar, Stanley G Kimani, Vladyslav Kholodovych, Canan Kasikara, Kensaku Mizuno, Oleta Sandiford, Pranela Rameshwar, Sergei V Kotenko, Raymond B Birge
The Tyro3, Axl, and Mertk (TAM) receptors are homologous type I receptor tyrosine kinases that have critical functions in the clearance of apoptotic cells in multicellular organisms. TAMs are activated by their endogenous ligands, growth arrest-specific 6 (Gas6), and protein S (Pros1), that function as bridging molecules between externalized phosphatidylserine (PS) on apoptotic cells and the TAM ectodomains. However, the molecular mechanisms by which Gas6/Pros1 promote TAM activation remains elusive. Using TAM/IFNγR1 reporter cell lines to monitor functional TAM activity, we found that Gas6 activity was exquisitely dependent on vitamin K-mediated γ-carboxylation, whereby replacing vitamin K with anticoagulant warfarin, or by substituting glutamic acid residues involved in PS binding, completely abrogated Gas6 activity as a TAM ligand...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163481/pro-resolving-mediators-in-regulating-and-conferring-macrophage-function
#19
REVIEW
Jesmond Dalli, Charles N Serhan
Macrophages are central in coordinating the host response to both sterile and infective insults. Clearance of apoptotic cells and cellular debris is a key biological action preformed by macrophages that paves the way to the resolution of local inflammation, repair and regeneration of damaged tissues, and re-establishment of function. The essential fatty acid-derived autacoids termed specialized pro-resolving mediators (SPM) play central roles in promoting these processes. In the present article, we will review the role of microvesicles in controlling macrophage efferocytosis and SPM production...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162596/lactadherin-promotes-microvesicle-clearance-to-prevent-coagulopathy-and-improves-survival-of-severe-tbi-mice
#20
Yuan Zhou, Wei Cai, Zilong Zhao, Tristan Hilton, Min Wang, Jason Yeon, Wei Liu, Fangyi Zhang, Fu-Dong Shi, Xiaoping Wu, Perumal Thiagarajan, Min Li, Jianning Zhang, Jing-Fei Dong
Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 µg/kg 30 min before (preconditioning) or 30 min after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs...
November 21, 2017: Blood
keyword
keyword
69830
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"