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https://www.readbyqxmd.com/read/29780001/automated-typing-of-red-blood-cell-and-platelet-antigens-a-whole-genome-sequencing-study
#1
William J Lane, Connie M Westhoff, Nicholas S Gleadall, Maria Aguad, Robin Smeland-Wagman, Sunitha Vege, Daimon P Simmons, Helen H Mah, Matthew S Lebo, Klaudia Walter, Nicole Soranzo, Emanuele Di Angelantonio, John Danesh, David J Roberts, Nick A Watkins, Willem H Ouwehand, Adam S Butterworth, Richard M Kaufman, Heidi L Rehm, Leslie E Silberstein, Robert C Green
BACKGROUND: There are more than 300 known red blood cell (RBC) antigens and 33 platelet antigens that differ between individuals. Sensitisation to antigens is a serious complication that can occur in prenatal medicine and after blood transfusion, particularly for patients who require multiple transfusions. Although pre-transfusion compatibility testing largely relies on serological methods, reagents are not available for many antigens. Methods based on single-nucleotide polymorphism (SNP) arrays have been used, but typing for ABO and Rh-the most important blood groups-cannot be done with SNP typing alone...
May 17, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29764625/recognition-of-phenylthiocarbamide-ptc-in-taste-test-is-related-to-blood-group-b-phenotype-females-and-risk-of-developing-food-allergy-a-cross-sectional-brazilian-based-study
#2
Isac César Roldão Leite, José Carlos Dos Santos Júnior, Cinthya Clara Silva de Sousa, Alexandre Vasconcelos Lima, Ana Luisa Miranda-Vilela
Anti-nutritional factors, including hemagglutinins, are natural substances that reduce nutritional bioavailability and/or generate adverse physiological effects. Most are bitter toxic compounds, but present chemo-protective properties at low concentrations. Responses to phenylthiocarbamide (PTC) allow for an evaluation of humans' perception of bitter taste, a perception that has evolutionary advantages. Therefore, we hypothesized that relationships between food preference, dietary exposures and disease risk could reflect possible associations not only with the recognition threshold for the bitter taste of PTC, but also with ABO/Rh blood group phenotypes...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29724631/transfusion-policy-in-allogeneic-hematopoietic-stem-cell-transplantation
#3
REVIEW
Pervin Topcuoglu
The incompatibility of ABO blood group between the recipient and the donor is not a barrier to perform allogeneic hematopoietic stem cell transplantation (Allo-HSCT). However, ABO incompatibility may lead to many complications during and after stem cell transplantation at the early or late period. Therefore, the typing of the blood group of the recipient and the donor should be done prior to the transplantation. In addition, the ABO/Rh group of blood products for transfusion should be determined according to the type of ABO-incompatibility...
April 18, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29700043/enhancement-of-red-blood-cell-transfusion-compatibility-using-crispr-mediated-erythroblast-gene-editing
#4
Joseph Hawksworth, Timothy J Satchwell, Marjolein Meinders, Deborah E Daniels, Fiona Regan, Nicole M Thornton, Marieangela C Wilson, Johannes Gg Dobbe, Geert J Streekstra, Kongtana Trakarnsanga, Kate J Heesom, David J Anstee, Jan Frayne, Ashley M Toye
Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood groups. Edits are combined to generate a single cell line deficient in multiple antigens responsible for the most common transfusion incompatibilities: ABO (Bombay phenotype), Rh (Rhnull ), Kell ( K 0 ), Duffy (Duffynull ), GPB (S- s- U- )...
April 26, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29687613/free-living-continuous-hypo-hydration-and-cardiovascular-response-to-exercise-in-a-heated-environment
#5
Kate S Early, Conrad P Earnest, Bailey Theall, Nathan P Lemoine, Brian Harrell, Neil M Johannsen
Chronic dehydration (DEH) and heat stress combined with poor cardiovascular (CV) health may influence physiological responses to exercise. We examined the effects of free-living induced hypo-hydration on physiological responses to exercise in a heated environment and whether resting CV health is related to these changes. Participants (N = 16, 20.6 ± 1.2 years) were randomized to 3 days of voluntary fluid restriction (DEH) or intake (hydration [HYD]) followed by an exercise bout. CV health was assessed by flow-mediated dilation (FMD), pulse wave analysis, and heart rate variability (HRV)...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29687045/behavioral-thermoregulation-in-older-adults-with-cardiovascular-co-morbidities
#6
Zachary J Schlader, Gregory L Coleman, James R Sackett, Suman Sarker, Christopher L Chapman, David Hostler, Blair D Johnson
We tested the hypotheses that older adults with cardiovascular co-morbidities will demonstrate greater changes in body temperature and exaggerated changes in blood pressure before initiating thermal behavior. We studied twelve healthy younger adults (Younger, 25 ± 4 y) and six older adults ('At Risk', 67 ± 4 y) taking prescription medications for at least two of the following conditions: hypertension, type II diabetes, hypercholesterolemia. Subjects underwent a 90-min test in which they voluntarily moved between cool (18...
2018: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/29686318/microcirculation-and-biomarkers-in-patients-with-resistant-or-mild-to-moderate-hypertension-a-cross-sectional-study
#7
Camillo L C Junqueira, Maria Eliane C Magalhães, Andréa Araújo Brandão, Esmeralci Ferreira, Fátima Z G A Cyrino, Priscila A Maranhão, Maria das Graças C Souza, Daniel Alexandre Bottino, Eliete Bouskela
Microcirculation influences peripheral vascular resistance and therefore contributes to arterial blood pressure. The aim of this study was to investigate the correlation between serum markers of inflammation and microcirculatory parameters observed by nailfold videocapillaroscopy (NVC) in patients with resistant (RH, 58 [50-63] years, n = 25) or mild-to-moderate hypertension (MMH, 56 [47-64] years, n = 25) compared to normotensive patients (control group (CG), 33 [27-52] years, n = 25). C-reactive protein (CRP), endothelin, adiponectin, I-CAM and V-CAM levels were obtained by laboratory analysis...
April 23, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29664112/efficacy-of-d-red-blood-cell-transfusion-and-rituximab-therapy-in-autoimmune-hemolytic-anemia-with-anti-d-and-panreactive-autoantibodies-arising-after-hematopoietic-stem-cell-transplant
#8
Keiji Minakawa, Hitoshi Ohto, Hiroyasu Yasuda, Shunichi Saito, Kinuyo Kawabata, Kazuei Ogawa, Kenneth E Nollet, Kazuhiko Ikeda
BACKGROUND: Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies to red blood cells (RBCs), which can be panreactive and/or specific to Rh/other blood group antigens. We report a severe case of AIHA after bone marrow transplantation (BMT) due to autoanti-D triggered by reactivation of Epstein-Barr virus (EBV) infection. A combined strategy of D- RBC transfusion and administration of anti-CD20 monoclonal antibody (MoAb) resolved the hemolysis. CASE REPORT: A 33-year-old male underwent allogeneic BMT from an ABO-identical and HLA-matched unrelated male donor...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29657543/association-of-abo-and-rh-blood-groups-with-breast-cancer
#9
Sultan Ayoub Meo, Faryal Suraya, Badar Jamil, Fwziah Al Rouq, Anusha Sultan Meo, Kamran Sattar, Mohammad Javed Ansari, Saleh A Alasiri
Objectives: The aim of this study was to determine the association of "ABO" and "Rhesus" blood groups with incidence of breast cancer. Methods: In this study, we identified 70 research documents from data based search engines including "PubMed", "ISI-Web of Knowledge", "Embase" and "Google Scholar". The research papers were selected by using the primary key-terms including "ABO blood type", "Rhesus" blood type and "breast cancer"...
November 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29656499/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-analysis-of-36-blood-group-alleles-among-396-thai-samples-reveals-region-specific-variants
#10
Philaiphon Jongruamklang, Christoph Gassner, Stefan Meyer, Aksarakorn Kummasook, Marion Darlison, Chayanun Boonlum, Surin Chanta, Beat M Frey, Martin L Olsson, Jill R Storry
BACKGROUND: Blood group phenotype variation has been attributed to potential resistance to pathogen invasion. Variation was mapped in blood donors from Lampang (northern region) and Saraburi (central region), Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized and the data were correlated with phenotypes. The high incidence of the Vel-negative phenotype previously reported in Thais was investigated. STUDY DESIGN AND METHODS: DNA from 396 blood donors was analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry...
April 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29616672/erythrocyte-phenotype-in-a-pregnant-woman-of-sri-lanka-description-of-the-case-and-complications-related-to-communication-problems
#11
Alvaro Ringressi, Veronica Cunsolo, Francesca Malentacchi, Simone Pozzessere
BACKGROUND: The Bombay phenotype is a rare genetic trait which is characterized by the absence of A, B and H antigens on red cells as well as in body secretions. The serum shows the presence of antibodies against antigen H. Patients with this rare blood type are not easily transfusable. We had observed a woman aged 18, at the 20th week of pregnancy, native of Sri Lanka, with an IgG and IgM class anti-H. We report the case and the clinical issues arisen. MATERIALS AND METHODS: The determination of ABO, Rh[D] group, the indirect antiglobulin test (IAT) were performed in tube techniques and in neutral gel microcolumn...
January 2018: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29607968/the-sglt2-inhibitor-dapagliflozin-significantly-improves-the-peripheral-microvascular-endothelial-function-in-patients-with-uncontrolled-type-2-diabetes-mellitus
#12
Seigo Sugiyama, Hideaki Jinnouchi, Noboru Kurinami, Kunio Hieshima, Akira Yoshida, Katsunori Jinnouchi, Hiroyuki Nishimura, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Tomio Jinnouchi
Objective Sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce cardiovascular events and decrease the body fat mass in patients with type 2 diabetes mellitus (T2DM). We examined whether or not the SGLT2-inhibitor dapagliflozin can improve the endothelial function associated with a reduction in abdominal fat mass. Methods We prospectively recruited patients with uncontrolled (hemoglobin A1c [HbA1c] >7.0%) T2DM who were not being treated by SGLT2 inhibitors. Patients were treated with add-on dapagliflozin (5 mg/day) or non-SGLT2 inhibitor medicines for 6 months to improve their HbA1c...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29602925/-risk-factors-for-adverse-course-of-gastric-and-duodenal-peptic-ulcer
#13
Olena M Komar, Nataliya M Kizlova, Oleksandra D Trylevych, Vasyl V Kravchenko
OBJECTIVE: Introduction: High morbidity rate, frequent relapses, and significant economic losses give reasons for highlighting the peptic ulcer disease as the most topical medical-statistical problem. The aim of the study is to assess the influence of the main risk factors on the course of gastric and duodenal peptic ulcer. PATIENTS AND METHODS: Materials and methods: We formed up the risk groups consisted of patients with 12 modified (4) and regular (8) factors, each characterized with its own signs and gradations...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29595460/-distribution-of-rh-blood-group-in-51-283-cases-of-inpatients-and-voluntary-blood-donors
#14
Ting Ma, Jiangcun Yang, Yaojun Song, Wenhua Wang, Xinxin Xie, Ping Chen, Yingqun Yang, Jingyan Chang, Miaoni Wang
Objective To investigate the distribution characteristics of Rh blood group in 51 283 cases of inpatients and voluntary blood donors. Methods Micro-column gel test was used to detect RhD, RhE, Rhe, RhC, Rhc antigen in 31 818 cases of hospitalized patients and 19 465 cases of voluntary blood donors. Results There were significant differences in Rh blood type distribution between inpatients and voluntary blood donors. The mainly phenotype of Rh blood group in the inpatients were DCCee (41.64%) and DCcEe (36.58%), and Rh blood type in voluntary blood donors were DCCee (41...
January 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29593909/qualitative-analysis-of-primary-fingerprint-pattern-in-different-blood-group-and-gender-in-nepalese
#15
Sudikshya Kc, Niroj Maharjan, Nischita Adhikari, Pragya Shrestha
Dermatoglyphics, the study of epidermal ridges on palm, sole, and digits, is considered as most effective and reliable evidence of identification. The fingerprints were studied in 300 Nepalese of known blood groups of different ages and classified into primary patterns and then analyzed statistically. In both sexes, incidence of loops was highest in ABO blood group and Rh +ve blood types, followed by whorls and arches, while the incidence of whorls was highest followed by loops and arches in Rh -ve blood types...
2018: Anatomy Research International
https://www.readbyqxmd.com/read/29593462/abo-rhesus-and-kell-antigens-alleles-and-haplotypes-in-west-bengal-india
#16
Debapriya Basu, Suvro Sankha Datta, Celina Montemayor, Prasun Bhattacharya, Krishnendu Mukherjee, Willy A Flegel
Background: Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India. Methods: We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood group systems were determined by standard serologic methods in tubes. Allele and haplotype frequencies were calculated with an iterative method that yielded maximum-likelihood estimates under the assumption of a Hardy-Weinberg equilibrium...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29564997/effect-of-the-physical-activity-program-on-the-treatment-of-resistant-hypertension-in-primary-care
#17
Piotr J Kruk, Michał Nowicki
BACKGROUND: Regular physical activity is widely recommended for patients with arterial hypertension as an essential component of lifestyle modification. Much less is known about the impact of physical exercise on the management of treatment of resistant hypertension (RH). The aim was to assess the effect of physical activity program intensified by mobile phone text reminders on blood pressure control in subjects with RH managed in the primary care. METHODS: In total, 53 patients with primary hypertension were qualified, including 27 who met the criteria for RH and 26 with well-controlled hypertension (WCH)...
March 22, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29563682/anti-kp-a-alloantibody-development-of-a-rare-alloantibody-in-a-non-hodgkin-s-lymphoma-patient-of-indian-origin
#18
Sadhana Mangwana, Vivek Gangwar
The Kell blood group system is complex, contains many antigens, highly immunogenic, and potent in triggering immune reactions. Antibodies to Kell blood group system are the most common immune red cell antibodies, following ABO and Rh. However, among the anti-Kell antibodies; anti-Kpa is extremely rare. We report an interesting case of Anti-Kpa in a 59-year-old female patient of Non-Hodgkin's Lymphoma, post radiotherapy, who first developed warm autoantibody and later developed anti-Kpa alloantibody on multiple transfusions...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29563680/a-rare-case-of-hemolytic-disease-of-newborn-due-to-weak-d-d-unknown-antigen-in-child
#19
Nirav Ramesh Dava, Alok Upadhyaya, Neha Agarwal, Amarjeet Mehta, Vijaypal Choudhary, Gourav Goyal
We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3rd order male child of G3 P3 A0 mother was admitted at 8th h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D antigen was positive in baby. Hematological parameters showed all the signs of ongoing hemolysis, and the bilirubin level was in the zone of exchange transfusion. Exchange transfusion was done. An intravenous immunoglobulin was given to child after that...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29563676/an-approach-to-incompatible-cross-matched-red-cells-our-experience-in-a-major-regional-blood-transfusion-center-at-kolkata-eastern-india
#20
Prasun Bhattacharya, Eeshita Samanta, Nowroz Afroza, Archana Naik, Rathindranath Biswas
INTRODUCTION: With the increased utilization of immunohematology (IH) analyzers in the transfusion medicine, type, and screen policy is the method of choice. Still, the importance of routine crossmatching could not be overruled. Here, we tried to understand the clinical conditions and safety of red cell transfusion and their outcomes. MATERIALS AND METHODS: This prospective study was conducted by IH laboratory, Medical College Kolkata, Blood Bank from October 1, 2015 to March 31, 2016...
January 2018: Asian Journal of Transfusion Science
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