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https://www.readbyqxmd.com/read/28097699/maternal-red-blood-cell-alloantibodies-identified-in-blood-samples-obtained-from-iranian-pregnant-women-the-first-population-study-in-iran
#1
Ehsan Shahverdi, Mostafa Moghaddam, Fateme Gorzin
BACKGROUND: The objective was to determine the frequency of occurrence of alloantibodies among pregnant women in Iran. STUDY DESIGN AND METHODS: This was a prospective cross-sectional study, which was carried out in the immunohematology reference laboratory of the Iranian Blood Transfusion Organization in Tehran, Iran, in 2008 to 2015. Screening and identification of red blood cell (RBC) alloantibodies was done on the sera of 7340 pregnant females using the standard tube method and gel column agglutination technique...
January 2017: Transfusion
https://www.readbyqxmd.com/read/28081120/epidemiology-of-chikungunya-virus-outbreaks-in-guadeloupe-and-martinique-2014-an-observational-study-in-volunteer-blood-donors
#2
Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie
BACKGROUND: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases. METHODS/PRINCIPAL FINDINGS: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28077075/protection-via-a-rom4-dna-vaccine-and-peptide-against-toxoplasma-gondii-in-balb-c-mice
#3
Yali Han, Aihua Zhou, Gang Lu, Guanghui Zhao, Lin Wang, Jingjing Guo, Pengxia Song, Jian Zhou, Huaiyu Zhou, Hua Cong, Shenyi He
BACKGROUND: Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite with a broad host range including most warm-blooded animals, including humans. T. gondii surface antigen 1 (SAG1) is a well-characterized T. gondii antigen. T. gondii expresses five nonmitochondrial rhomboid intramembrane proteases, TgROM1-5. TgROM4 is uniformly distributed on the surface of T. gondii and involved in regulating MIC2, MIC3, MIC6, and AMA1 during T. gondii invasion of host cells. Bioinformatics have predicted ROM4 B-cell and T-cell epitopes...
January 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28065750/physicochemical-properties-and-biological-activities-of-novel-blend-films-using-oxidized-pectin-chitosan
#4
Asma Chetouani, Nadège Follain, Stéphane Marais, Christophe Rihouey, Meriem Elkolli, Mahmoud Bounekhel, Djafer Benachour, Didier Le Cerf
Pectin has been widely used in a variety of biomedical applications. In this study, it was modified with sodium periodate as an oxidant and characterized by physicochemical methods Periodate oxidation increased the contents of dialdehyde units and carboxyl groups in pectin, and a decrease in pectin viscosity was measured. The oxidization reaction led to a significant decrease in all values of molecular weight and size (Mn, Mw, [η] and Rh) as determined by size exclusion chromatography (SEC), which allowed the selection of the oxidized pectin to be added to chitosan...
January 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28040400/emerging-strategies-of-blood-group-genotyping-for-patients-with-hemoglobinopathies
#5
REVIEW
A Belsito, K Magnussen, C Napoli
Red cell alloimmunization is a serious problem in chronically transfused patients. A number of high-throughput DNA assays have been developed to extend or replace traditional serologic antigen typing. DNA-based typing methods may be easily automated and multiplexed, and provide reliable information on a patient. Molecular genotyping promises to become cheaper, being not dependent on serologic immunoglobulin reagents. Patients with hemoglobinopathies could benefit from receiving extended genomic typing. This could limit post transfusional complications depending on subtle antigenic differences between donors and patients...
December 9, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28034588/abo-blood-group-and-prevalence-of-osteoporosis-and-osteopenia-in-the-elderly-population-an-amirkola-health-and-ageing-project-ahap-based-study
#6
Nayer Seyfizadeh, Narges Seyfizadeh, Hajar Negahdar, Seyed Reza Hosseini, Hajighorban Nooreddini, Hadi Parsian
Osteoporosis is known as a degenerative disease of the skeletal system and its main complication is fracture, which influences quality of life in the elderly. There are 4 major blood groups in humans based on the presence of A and B antigens. According to the investigations, there are reported relations between blood types and some diseases. In this study, the association between the ABO blood group and the prevalence of osteoporosis and osteopenia in an elderly population was investigated. Medical records of 990 elderly people were investigated in a cross-sectional study and the association between their blood group and the incidence of osteoporosis and osteopenia was analyzed using SPSS version 17...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28012709/the-history-and-challenges-of-blood-donor-screening-in-china
#7
REVIEW
Ling Li, Ka Yi Li, Ke Yan, Guojin Ou, Wenhui Li, Jue Wang, Ning Song, Li Tian, Xin Ji, Yongjun Chen, Xiaohua Liang, Zhong Liu, Yanyun Wu
Since the establishment of People's Republic of China in 1949, the Chinese government has encountered several catastrophes related to transfusion transmitted diseases. The government's increasing attention to blood safety has prompted the initiation of a series of policies and measures that have enhanced the level of safety for the blood supply and met the basic clinical demands of blood for 1.3 billion people in the country. Blood donation screening strategies in China predominantly comprise donor screening and donor testing...
November 12, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28011096/minimally-invasive-radical-hysterectomy-for-cervical-cancer-is-associated-with-reduced-morbidity-and-similar-survival-outcomes-compared-with-laparotomy
#8
Elisabeth Diver, Emily Hinchcliff, Allison Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield Growdon
STUDY OBJECTIVE: In cervical cancer, there are limited randomized trials to indicate whether patient outcomes are equivalent after radical hysterectomy (RH) via minimally invasive (MIS) or traditional laparotomy (XL) approach. The aim of this study was to assess patient outcomes of women with cervical cancer undergoing upfront RH at two large academic institutions to determine if mode of surgery affects patient outcomes. DESIGN: A retrospective cohort study Design classification: Canadian Task Force Classification II-1 SETTING: Two academic medical institutions in the United States from 2000 to 2013 PATIENTS: Women undergoing upfront RH for cervical cancer INTERVENTION: Minimally invasive techniques (laparoscopic and robotic) for RH, as compared with XL MEASUREMENTS AND MAIN RESULTS: 383 women met eligibility requirements...
December 20, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28007780/ficin-treated-red-cells-help-identify-clinically-significant-alloantibodies-masked-as-reactions-of-undetermined-specificity-in-gel-microtubes
#9
Ben C Hill, Courtney A Hanna, Jill Adamski, Huy P Pham, Marisa B Marques, Lance A Williams
Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatment); however, they are often underutilized due to concerns over expense. Ficin is known to enhance reactivity caused by antibodies in the ABO, Rh, Kidd, Lewis, I, and P blood group systems, while destroying reactivity of antibodies in the Duffy, and MNS blood group systems...
December 22, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/28005561/risk-factors-for-collegiate-swimmers-hospitalized-with-exertional-rhabdomyolysis
#10
Margo R Stanfa, Navjeet N Silles, Amanda Cooper, Sara Arena, Kristin Landis-Piwowar, Carrie Aprik, Tamara Hew-Butler
OBJECTIVE: To identify midseason risk factors for symptomatic exertional rhabdomyolysis (sER) in swimmers after a novel upper body workout. DESIGN: Retrospective (1) survey and (2) analyses of observational laboratory data conducted over a 16-week training period, 2 months before sER. SETTING: Midwest University. PARTICIPANTS: Thirty-four collegiate swimmers. INDEPENDENT VARIABLES: (1) Motivation, symptoms, and supplements for survey variables...
January 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/27999217/a-survey-on-lifestyle-and-level-of-biomarkers-of-environmental-exposure-in-residents-in-civitavecchia-italy
#11
Carla Ancona, Lisa Bauleo, Giovanni Biscotti, Beatrice Bocca, Stefano Caimi, Fabio Cruciani, Sabrina Di Lorenzo, Morena Petrolati, Anna Pino, Giovanna Piras, Augusto Pizzabiocca, Silvia Rabbiosi, Flavia Ruggieri, Chelo Salatino, Alessandro Alimonti, Francesco Forastiere
BACKGROUND: The assessment of individual exposure to toxicants in industrially contaminated areas is difficult when multiple productions are active close to residential areas. Two thermoelectric power plants and a large harbor have been operating since the '60s in the area of Civitavecchia (North of Rome). METHODS: The ABC (Ambiente e Biomonitoraggio nell'area di Civitavecchia, Environment and Biomonitoring in Civitavecchia) program involved, in the period 2013-2014, residents in Civitavecchia and in the nearby municipalities (Santa Marinella, Allumiere, Tolfa and Tarquinia)...
October 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27984617/-molecular-genetic-analysis-of-four-cases-with-weak-d-variant-of-rh-blood-type
#12
Yunlei He, Gang Deng, Deyi Xu, Wei Liang, Lu Yu
OBJECTIVE: To explore the molecular basis of 4 cases with weak D variant of Rh blood type. METHODS: Routine serological testing was applied to determine the D, C, c, E and e antigens of the Rh blood group. The D antigen was further detected with an indirect antiglobulin test. RHD zygosity was detected by sequence-specific primer PCR method. All exons and flanking intron regions of the RHD gene were sequenced. RESULTS: The samples were determined as weak D phenotype by serological testing...
December 10, 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/27968915/dynamic-contrast-enhanced-mri-to-predict-response-to-vinorelbine-cisplatin-alone-or-with-rh-endostatin-in-patients-with-non-small-cell-lung-cancer-and-bone-metastases-a-randomised-double-blind-placebo-controlled-trial
#13
Rui Zhang, Zhi-Yu Wang, Yue-Hua Li, Yao-Hong Lu, Shuai Wang, Wen-Xi Yu, Hui Zhao
BACKGROUND: Metastatic bone disease is a frequent complication of advanced non-small-cell lung cancer and causes skeletal-related events which result in a poor prognosis. A standard method to assess the therapeutic response of bone metastases does not currently exist. We used dynamic contrast-enhanced MRI to obtain quantitative measures to assess the suitability of this technique to gauge therapeutic response to vinorelbine-cisplatin plus rh-endostatinfor previously untreated non-small cell lung cancer with bone metastases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27900173/how-accurate-are-the-wrist-based-heart-rate-monitors-during-walking-and-running-activities-are-they-accurate-enough
#14
Sarah E Stahl, Hyun-Sung An, Danae M Dinkel, John M Noble, Jung-Min Lee
BACKGROUND: Heart rate (HR) monitors are valuable devices for fitness-orientated individuals. There has been a vast influx of optical sensing blood flow monitors claiming to provide accurate HR during physical activities. These monitors are worn on the arm and wrist to detect HR with photoplethysmography (PPG) techniques. Little is known about the validity of these wearable activity trackers. AIM: Validate the Scosche Rhythm (SR), Mio Alpha (MA), Fitbit Charge HR (FH), Basis Peak (BP), Microsoft Band (MB), and TomTom Runner Cardio (TT) wireless HR monitors...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27893356/single-stranded-dna-aptamer-targeting-and-neutralization-of-anti-d-alloantibody-a-potential-therapeutic-strategy-for-haemolytic-diseases-caused-by-rhesus-alloantibody
#15
Yinze Zhang, Fan Wu, Manni Wang, Naibao Zhuang, Huayou Zhou, Hua Xu
BACKGROUND: Rhesus (Rh) D antigen is the most important antigen in the Rh blood group system because of its strong immunogenicity. When RhD-negative individuals are exposed to RhD-positive blood, they may produce anti-D alloantibody, potentially resulting in delayed haemolytic transfusion reactions and Rh haemolytic disease of the foetus and newborn, which are difficult to treat. Inhibition of the binding of anti-D antibody with RhD antigens on the surface of red blood cells may effectively prevent immune haemolytic diseases...
November 11, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#16
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27885153/karl-otto-landsteiner-1868-1943-physician-biochemist-immunologist
#17
Armond S Goldman, Frank C Schmalsteig
Karl Landsteiner applied the sciences of biochemistry, pathology, microbiology, and immunology in medical research to great success during the first half of the 20th century. Although he is principally known for elucidating the major blood group antigens A and B and their isoantibodies for which he was awarded the Nobel Prize in Physiology or Medicine, Landsteiner made many other important medical discoveries. In that respect, he ascertained that paralytic poliomyelitis was due to a virus, the pancreas was damaged in cystic fibrosis, simple chemicals called haptens were able to combine with antibodies, and the Rh antigen that was later found to be the principal cause of hemolytic anemia of the newborn was found in most humans...
November 24, 2016: Journal of Medical Biography
https://www.readbyqxmd.com/read/27843051/effect-of-hormone-replacement-therapy-with-the-anti-mineralocorticoid-progestin-drospirenone-compared-to-tibolone-on-endothelial-function-and-central-haemodynamics-in-post-menopausal-women
#18
Cristiana Vitale, Caterina Mammi, Marco Gambacciani, Novella Russo, Ilaria Spoletini, Massimo Fini, Maurizio Volterrani, Giuseppe M C Rosano
Drospirenone (DRSP) is an antialdosterone agent with progestogenic and antiandrogenic effects. This compound, has been recently used in combination with 17β-estradiol (E2) as hormonal therapy in postmenopausal women and has been shown to exert a significant antihypertensive effect in hypertensive post-menopausal women. Aim of the present study was to compare the effect of DRSP/E2 with those of Tibolone (T) on endothelial function, arterial stiffness, and lipid profile of early postmenopausal women naïve on post-menopausal hormonal therapy...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27826971/predictors-of-blood-pressure-control-in-patients-with-resistant-hypertension
#19
J Pales, G Kamensky, J Payer
BACKGROUND: Uncontrolled resistant hypertension (RH) defined by the mean 24-hour ambulatory blood pressure (ABPM) represents an independent risk factor in hypertensive patients. Predictors of blood pressure (BP) control in RH are not yet clearly defined. OBJECTIVES: To evaluate the predictors of BP control in RH patients with repeated ABPM measurements. METHODS: 114 consecutive patients from outpatient cardiology office fulfilling criteria for RH (office BP ≥ 140 and/or 90 mmHg, with treatment of ≥ 3 antihypertensive drugs, including diuretic, or controlled BP with > 3 drugs), with two consecutive ABPM studies were compared in clinical characteristics according to BP control assessed by ABPM RESULTS: After the second ABPM, BP was controlled in 25...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27818472/a-single-session-of-neuromuscular-electrical-stimulation-enhances-vascular-endothelial-function-and-peripheral-blood-circulation-in-patients-with-acute-myocardial-infarction
#20
Shinya Tanaka, Takashi Masuda, Kentaro Kamiya, Nobuaki Hamazaki, Ayako Akiyama, Yumi Kamada, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Junya Ako
This study aimed to investigate whether a single session of neuromuscular electrical stimulation (NMES) can enhance vascular endothelial function and peripheral blood circulation in patients with acute myocardial infarction (AMI). Thirty-four male patients with AMI were alternately assigned to 2 groups, and received NMES with muscle contraction (NMES group, n = 17) or without muscle contraction (control group, n = 17) after admission. NMES was performed for quadriceps and gastrocnemius muscles of both legs for 30 minutes...
December 2, 2016: International Heart Journal
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