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https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#1
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679857/the-risk-of-immune-related-endocrine-disorders-associated-with-anti-pd-1-inhibitors-therapy-for-solid-tumors-a-systematic-review-and-meta-analysis
#2
Qiang Su, Xiao-Chen Zhang, Di-Ya Wang, Huai-Rong Zhang, Cheng Zhu, Yan-Li Hou, Jun-Li Liu, Zu-Hua Gao
BACKGROUND: We performed a systematic review and meta-analysis to evaluate the risk of immune-related endocrine disorders associated with PD-1 inhibitors therapy for solid tumors. METHODS: An Embase and PubMed search through December 6, 2017, using the following keywords was performed: immune-related endocrine disorders, and PD-1 inhibitors, etc. The data were analyzed using R 3.4.3 (R Project) and the metafor package. Patients treated with chemotherapy alone were used as control for the purpose of comparison...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679746/prevalence-of-cfr-in-enterococcus-faecalis-strains-isolated-from-swine-farms-in-china-predominated-cfr-carrying-pcppf5-like-plasmids-conferring-non-linezolid-resistance-phenotype
#3
Liang-Xing Fang, Jia-Hong Duan, Mu-Ya Chen, Hui Deng, Hua-Qing Liang, Yan Q Xiong, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
The cfr gene associated with linezolid resistance has attracted wide attention. However, little is known about its prevalence and mode of transmission in Enterococcus faecalis. In this study, we investigate the prevalence and genetic environment of the cfr gene in 91 E. faecalis isolates collected from swine faecal swabs in 30 farms in Guangdong Province, China in 2012. A relatively high prevalence of cfr was identified in E. faecalis isolates (11/91, 12.1%) by PCR. All the cfr-positive E. faecalis strains had a multidrug-resistance phenotype including erythrocin, tetracycline, gentamicin, kanamicin and ciprofloxacin, except vancomycin and linezolid...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29679009/nucleus-accumbens-controls-wakefulness-by-a-subpopulation-of-neurons-expressing-dopamine-d-1-receptors
#4
Yan-Jia Luo, Ya-Dong Li, Lu Wang, Su-Rong Yang, Xiang-Shan Yuan, Juan Wang, Yoan Cherasse, Michael Lazarus, Jiang-Fan Chen, Wei-Min Qu, Zhi-Li Huang
Nucleus accumbens (NAc) is involved in behaviors that depend on heightened wakefulness, but its impact on arousal remains unclear. Here, we demonstrate that NAc dopamine D1 receptor (D1 R)-expressing neurons are essential for behavioral arousal. Using in vivo fiber photometry in mice, we find arousal-dependent increases in population activity of NAc D1 R neurons. Optogenetic activation of NAc D1 R neurons induces immediate transitions from non-rapid eye movement sleep to wakefulness, and chemogenetic stimulation prolongs arousal, with decreased food intake...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678646/inferring-spatial-patterns-and-drivers-of-population-divergence-of-neolitsea-sericea-lauraceae-based-on-molecular-phylogeography-and-landscape-genomics
#5
Ya-Nan Cao, Ian J Wang, Lu-Yao Chen, Yan-Qian Ding, Lu-Xian Liu, Ying-Xiong Qiu
The relative roles of geography, climate and ecology in driving population divergence and (incipient) speciation has so far been largely neglected in studies addressing the evolution of East Asia's island flora. Here, we employed chloroplast and ribosomal DNA sequences and restriction site-associated DNA sequencing (RADseq) loci to investigate the phylogeography and drivers of population divergence of Neolitsea sericea. These data sets support the subdivision of N. sericea populations into the Southern and Northern lineages across the 'Tokara gap'...
April 17, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#6
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678580/microrna-185-inhibits-the-growth-and-proliferation-of-osteoblasts-in-fracture-healing-by-targeting-pth-gene-through-down-regulating-wnt-%C3%AE-catenin-axis-in-an-animal-experiment
#7
Chang-Jiang Yao, Yang Lv, Cheng-Jun Zhang, Jia-Xin Jin, Li-Hu Xu, Jin Jiang, Bin Geng, Hong Li, Ya-Yi Xia, Meng Wu
Fracture healing is a repair process of a mechanical discontinuity loss of force transmission, and pathological mobility of bone. Increasing evidence suggests that microRNA (miRNA) could regulate chondrocyte, osteoblast, and osteoclast differentiation and function, indicating miRNA as key regulators of bone formation, resorption, remodeling, and repair. Hence, during this study, we established a right femur fracture mouse model to explore the effect microRNA-185 (miR-185) has on osteoblasts in mice during fracture healing and its underlying mechanism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678477/corrigendum-to-elimination-of-methane-in-exhaust-gas-from-biogas-upgrading-process-by-immobilized-methane-oxidizing-bacteria-bioresour-technol-231-2017-124-128
#8
Ya-Min Wu, Jing Yang, Xiao-Lei Fan, Shan-Fei Fu, Meng-Ting Sun, Rong-Bo Guo
No abstract text is available yet for this article.
April 17, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29677680/transcriptomic-identification-of-salt-related-genes-and-de-novo-assembly-in-common-buckwheat-f-esculentum
#9
Qi-Huan Lu, Ya-Qi Wang, Jin-Nan Song, Hong-Bing Yang
Common buckwheat (F. esculentum), annually herbaceous crop, is prevalent in people's daily life with the increasing development of economics. Compared with wheat, it is highly praised with high content of rutin and flavonoid. Common buckwheat is recognized as healthy food with good taste, and the product price of which such as noodles, flour, bread and so on are higher than wheat, and the seeds of which are bigger than that of tartary buckwheat, so if common buckwheat are planted more widely, people will spend less money on this healthy and delicious food...
April 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677669/toxicological-interaction-of-multi-component-mixtures-to-vibrio-qinghaiensis-sp-q67-induced-by-at-least-three-components
#10
Ya-Qian Xu, Shu-Shen Liu, Ye Fan, Kai Li
It has been stated by researchers that the antibiotic polymyxin B sulfate (POL) is a key component inducing time-dependent antagonism in freshwater luminescent bacteria, Vibrio qinghaiensis sp.-Q67, exposed in the ternary mixture system of the ionic liquids, pesticide and antibiotics. However, the previous statement is limited to ternary and quaternary mixtures without considering situations such as the binary system. In order to prove the direct inducing of antagonism by POL in a more complete and systematic way, two categories of experiments (adding POL in non-antagonistic ternary system and decomposing antagonistic ternary system with POL into the binary system) have been conducted in this paper...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677531/synthesis-of-nanowire-bundle-like-wo-3-w-18-o-49-heterostructures-for-highly-sensitive-nh-3-sensor-application
#11
Ya Xiong, Zongye Zhu, Tianchao Guo, Hui Li, Qingzhong Xue
Heterojunctions are very promising structures due to their hybrid properties, which are usually obtained via a multistep growth process. However, in this paper, WO3 -W18 O49 heterostructures are synthesized via a novel one-step approach by using isopropanol as reaction media and are applied in NH3 gas detection for the first time. The obtained WO3 -W18 O49 heterostructures with loose nanowire bundle-like morphology show a response value of 23.3 toward 500 ppm NH3 at 250 °C, which is 5.63 times higher than that of pristine W18 O49 ...
April 14, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29677396/hydrocarbons-mediate-seed-dispersal-a-new-mechanism-of-vespicochory
#12
Gao Chen, Zheng-Wei Wang, Ping Wen, Wei Wei, Ya Chen, Hui Ai, Wei-Bang Sun
Vespicochory, seed dispersal by hornets, is an uncommon seed dispersal pattern in angiosperms. To date, this phenomenon has been recorded in only four families. Because of its rarity, the causes and consequences of vespicochory remain unclear. Hence, this seed dispersal syndrome is often regarded as anecdotal. Through field investigations, chemical analyses, electrophysiological tests, identification of chemosensory proteins from the antennae of hornets, and behavioral assays, we investigated whether olfactory and/or visual cues of the diaspores of Stemona tuberosa mediate the behavior of the social hornets and maintain their mutualism...
April 20, 2018: New Phytologist
https://www.readbyqxmd.com/read/29677385/identification-and-characterization-of-two-novel-c-type-lectins-from-the-larvae-of-housefly-musca-domestica-l
#13
Jing Zhou, Nai-Nai Fang, Ya Zheng, Kai-Yu Liu, Bin Mao, Li-Na Kong, Ya Chen, Hui Ai
Lectins and antimicrobial peptides (AMPs) are widely distributed in various insects and play crucial roles in primary host defense against pathogenic microorganisms. Two AMPs (cecropin and attacin) have been identified and characterized in the larvae of housefly. In this study, two novel C-type lectins (CTLs) were obtained from Musca domestica, while their agglutinating and antiviral properties were evaluated. Real-time PCR analysis showed that the mRNA levels of four immune genes (MdCTL1, MdCTL2, Cecropin, and Attacin) from M...
April 20, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29676579/antibacterial-indole-alkaloids-with-complex-heterocycles-from-voacanga-africana
#14
Cai-Feng Ding, Hong-Xia Ma, Jing Yang, Xu-Jie Qin, Guy S S Njateng, Hao-Fei Yu, Xin Wei, Ya-Ping Liu, Wan-Yi Huang, Zi-Feng Yang, Xin-Hua Wang, Xiao-Dong Luo
Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19- epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine...
April 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29676444/ethnic-disparity-in-primary-cutaneous-cd30-t-cell-lymphoproliferative-disorders-an-analysis-of-1496-cases-from-the-us-national-cancer-database
#15
Chang Su, Kevin A Nguyen, Harrison X Bai, Cheryl K Zogg, Ya Cao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang, Rong Xiao
Primary cutaneous CD30+ T cell lymphoproliferative disorders (PCLPD), the second most common type of primary cutaneous T cell lymphomas, accounts for approximately 25-30% of cutaneous T-cell lymphoma cases. However, only small retrospective studies have been reported. We aimed to identify prognostic factors and evaluate the overall survival (OS) of patients with PCLPD stratified by ethnicity. We identified 1496 patients diagnosed with PCLPD between 2004 and 2014 in the US National Cancer Database. Chi-square test and anova were used to evaluate differences in demographic and disease characteristics, socioeconomic factors and treatments received...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676122/-quality-control-of-guci-tablets-using-uplc-elsd-fingerprint-analysis-coupled-with-chemometrics
#16
Ya-Dan Wang, Zhong Dai, Cai-Lin Sun, Xian-Fu Wu, Shuang-Cheng Ma
Ultra-performance liquid chromatography-evaporative light scattering detection (UPLC-ELSD) fingerprint analysis method was established for quality control of Guci tablets. Chromatographic separation was performed on Waters Acquity UPLC BEH C₁₈ column (2.1 mm×100 mm, 1.7 μm) at 30 °C of column temperature. Acetonitrile-0.1% formic acid solution was adopted as mobile phase for gradient elution. The flow rate was set at 0.3 mL·min⁻¹, and the injection volume was 3 μL. Detection was carried out on an ELSD with a nitrogen pressure of 0...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675666/highly-efficient-deracemization-of-racemic-2-hydroxy-acids-in-a-three-enzyme-co-expression-system-using-a-novel-ketoacid-reductase
#17
Ya-Ping Xue, Chuang Wang, Di-Chen Wang, Zhi-Qiang Liu, Yu-Guo Zheng
Enantiopure 2-hydroxy acids (2-HAs) are important intermediates for the synthesis of pharmaceuticals and fine chemicals. Deracemization of racemic 2-HAs into the corresponding single enantiomers represents an economical and highly efficient approach for synthesizing chiral 2-HAs in industry. In this work, a novel ketoacid reductase from Leuconostoc lactis (LlKAR) with higher activity and substrate tolerance towards aromatic α-ketoacids was discovered by genome mining, and then its enzymatic properties were characterized...
April 20, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29675369/boxb-mediate-balb-c-mice-corneal-inflammation-through-a-tlr4-myd88-dependent-signaling-pathway-in-aspergillus-fumigatus-keratitis
#18
Min Liu, Cui Li, Gui-Qiu Zhao, Jing Lin, Cheng-Ye Che, Qiang Xu, Qian Wang, Rui Xu, Ya-Wen Niu
AIM: To investigate whether high-mobility group box 1 (HMGB1) Boxb exacerbates BALB/c mice corneal immune responses and inflammatory through the Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)-dependent signaling pathway in Aspergillus fumigatus ( A. fumigatus ) keratitis. METHODS: The mice corneas were pretreated with phosphate buffer saline (PBS), Boxb before A. fumigatus infection. The abdominal cavity extracted macrophages were pretreated with PBS, Boxb, TLR4 inhibitor (CLI-095), Dimethyl sulfoxide (DMSO) separately before A...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675012/histidine-metabolism-and-igpd-play-a-key-role-in-cefquinome-inhibiting-biofilm-formation-of-staphylococcus-xylosus
#19
Yong-Hui Zhou, Chang-Geng Xu, Yan-Bei Yang, Xiao-Xu Xing, Xin Liu, Qian-Wei Qu, Wen-Ya Ding, God'spower Bello-Onaghise, Yan-Hua Li
Staphylococcus xylosus ( S. xylosus ) is an AT-rich and coagulase-negative Staphylococcus (CNS). It is normally regarded as non-pathogenic, however, recent studies have demonstrated that it is related to human opportunistic infections and bovine mastitis. In addition, S. xylosus strains have the ability to form biofilm. Biofilms are also involved in chronic infections and antibiotic resistance, there are only a few reports about cefquinome inhibiting S. xylosus biofilm formation and the protein targets of cefquinome...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674962/invaginating-structures-in-mammalian-synapses
#20
REVIEW
Ronald S Petralia, Ya-Xian Wang, Mark P Mattson, Pamela J Yao
Invaginating structures at chemical synapses in the mammalian nervous system exist in presynaptic axon terminals, postsynaptic spines or dendrites, and glial processes. These invaginating structures can be divided into three categories. The first category includes slender protrusions invaginating into axonal terminals, postsynaptic spines, or glial processes. Best known examples of this category are spinules extending from postsynaptic spines into presynaptic terminals in forebrain synapses. Another example of this category are protrusions from inhibitory presynaptic terminals invaginating into postsynaptic neuronal somas...
2018: Frontiers in Synaptic Neuroscience
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