keyword
MENU ▼
Read by QxMD icon Read
search

ya

keyword
https://www.readbyqxmd.com/read/29053707/high-glucose-augments-angiotensinogen-in-human-renal-proximal-tubular-cells-through-hepatocyte-nuclear-factor-5
#1
Juan Wang, Yuki Shibayama, Hiroyuki Kobori, Ya Liu, Hideki Kobara, Tsutomu Masaki, Zhiyu Wang, Akira Nishiyama
High glucose has been demonstrated to induce angiotensinogen (AGT) synthesis in the renal proximal tubular cells (RPTCs) of rats, which may further activate the intrarenal renin-angiotensin system (RAS) and contribute to diabetic nephropathy. This study aimed to investigate the effects of high glucose on AGT in the RPTCs of human origin and identify the glucose-responsive transcriptional factor(s) that bind(s) to the DNA sequences of AGT promoter in human RPTCs. Human kidney (HK)-2 cells were treated with normal glucose (5...
2017: PloS One
https://www.readbyqxmd.com/read/29053518/role-of-homeodomain-interacting-protein-kinase-2-in-the-pathogenesis-of-tissue-fibrosis-in-keloid-derived-keratinocytes
#2
Yi-Xuan Zhao, Guo-You Zhang, An-Yuan Wang, Ya-Hong Chen, Da-Mu Lin, Qing-Feng Li
Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053304/purification-of-single-photons-from-room-temperature-quantum-dots
#3
Shih-Wen Feng, Chun-Yuan Cheng, Chen-Yeh Wei, Jen-Hung Yang, Yen-Ru Chen, Ya-Wen Chuang, Yang-Hsiung Fan, Chih-Sung Chuu
Single photon emitters are indispensable to photonic quantum technologies. Here, we demonstrate waveform-controlled high-purity single photons from room-temperature colloidal quantum dots. The purity of the single photons does not vary with the excitation power, thereby allowing the generation rate to be increased without compromising the single-photon quality.
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053251/electrochemiluminescent-pb2-driven-circular-etching-sensor-coupled-to-a-dna-micronet-carrier
#4
Wen-Bin Liang, Ying Zhuo, Ying-Ning Zheng, Cheng-Yi Xiong, Ya-Qin Chai, Ruo Yuan
Herein, an ultrasensitive electrochemiluminescent (ECL) strategy was designed based on the fabrication of a multi-interface DNA micronet-carrier via layer by layer hybridization of double-stranded DNAzyme-substrate to immobilize large amounts of ECL indicator, [Ru(dcbpy)2dppz]2+, in double-strand DNA on the electrode surface, generating enhanced ECL signals. When the double-stranded structures were cleaved circularly via Pb2+ in the detection sample, the ECL indicator was released, which resulted in a decreased ECL signal associated with the concentration of Pb2+, that had higher sensitivity and wider linear range...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29053192/dissociation-of-nnos-from-psd-95-promotes-functional-recovery-after-cerebral-ischaemia-in-mice-through-reducing-excessive-tonic-gaba-release-from-reactive-astrocytes
#5
Yu-Hui Lin, Hai-Ying Liang, Ke Xu, Huan-Yu Ni, Jian Dong, Hui Xiao, Lei Chang, Hai-Yin Wu, Fei Li, Dong-Ya Zhu, Chun-Xia Luo
Mechanisms underlying functional recovery after stroke are little known, and effective drug intervention during the delayed stage is desirable. One potential drug target, the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and postsynaptic density protein 95 (PSD-95), is critical to acute ischaemic damage and neurogenesis. We show that nNOS-PSD-95 dissociation induced by microinjection of a recombinant fusion protein Tat-nNOS-N1-133 or systemic administration of a small molecule ZL006 from days 4 to 10 after photothrombotic ischaemia in mice reduced excessive tonic inhibition in the peri-infarct cortex and ameliorated motor functional outcome...
October 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29052791/potential-diagnostic-performance-of-contrast-enhanced-ultrasound-and-tumor-markers-in-differentiating-combined-hepatocellular-cholangiocarcinoma-from-hepatocellular-carcinoma-and-cholangiocarcinoma
#6
Xiao-Wen Huang, Yang Huang, Li-da Chen, Zhu Wang, Zheng Yang, Jin-Ya Liu, Xiao-Yan Xie, Ming-De Lu, Shun-Li Shen, Wei Wang
PURPOSE: To evaluate the diagnostic performance of the combination of tumor markers [alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9)] and imaging features in differentiating combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). METHODS: Forty consecutive patients with pathologically proven CHC were retrospectively evaluated with contrast-enhanced ultrasound (CEUS). Additionally, 40 HCC and 40 CC patients who were randomly selected from the same period served as a control group...
October 20, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29052595/corrigendum-hydrogen-sulfide-induced-itch-requires-activation-of-cav3-2-t-type-calcium-channel-in-mice
#7
Xue-Long Wang, Bin Tian, Ya Huang, Xiao-Yan Peng, Li-Hua Chen, Jun-Cheng Li, Tong Liu
This corrects the article DOI: 10.1038/srep16768.
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29052559/efficacy-and-safety-of-niaoduqing-particles-for-delaying-moderate-to-severe-renal-dysfunction-a-randomized-double-blind-placebo-controlled-multicenter-clinical-study
#8
Ying Zheng, Guang-Yan Cai, Li-Qun He, Hong-Li Lin, Xiao-Hong Cheng, Nian-Song Wang, Gui-Hua Jian, Xu-Sheng Liu, Yu-Ning Liu, Zhao-Hui Ni, Jing-Ai Fang, Han-Lu Ding, Wang Guo, Ya-Ni He, Li-Hua Wang, Ya-Ping Wang, Hong-Tao Yang, Zhi-Ming Ye, Ren-Huan Yu, Li-Juan Zhao, Wen-Hua Zhou, Wen-Ge Li, Hui-Juan Mao, Yong-Li Zhan, Zhao Hu, Chen Yao, Ri-Bao Wei, Xiang-Mei Chen
BACKGROUND: Chronic kidney disease (CKD) with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage renal disease are limited. This study aimed to assess the efficacy and safety of the traditional Chinese medicine, Niaoduqing particles, for delaying renal dysfunction in patients with stage 3b-4 CKD. METHODS: The present study was a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052527/negative-genic-switch-of-her-2-in-the-primary-tumor-instead-of-the-synchronous-metastatic-nodal-lesions-after-neoadjuvant-chemotherapy-in-a-patient-with-primary-her2-positive-breast-cancer
#9
Hao-Ran Chen, Yu-Tuan Wu, Qiu-Bo Yu, Ya-Ying Yang, Yu-Xian Wei, Hong-Yuan Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: A few retrospective studies have indicated that neoadjuvant chemotherapy (NAC) in breast cancer may change biomarker profiles of the primary tumor. Little is known about the status of HER-2 gene of the synchronous nodal metastases when that of the residual tumor undergoes negative conversion in a neoadjuvant setting. CASE PRESENTATION: We describe a female patient with left breast cancer (T2N2M0) who underwent negative conversion of HER-2 in the primary tumor instead of the synchronous nodal lesions after NAC...
October 19, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29052525/epigenetic-mediated-zinc-finger-protein-671-downregulation-promotes-cell-proliferation-and-tumorigenicity-in-nasopharyngeal-carcinoma-by-inhibiting-cell-cycle-arrest
#10
Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma, Ying Sun
BACKGROUND: Epigenetic abnormalities play important roles in nasopharyngeal cancer (NPC), however, the epigenetic changes associated with abnormal cell proliferation remain unclear. METHODS: We detected epigenetic change of ZNF671 in NPC tissues and cell lines by bisulfite pyrosequencing. We evaluated zinc finger protein 671 (ZNF671) expression in NPC cell lines and clinical tissues using real-time PCR and western blotting. Then, we established NPC cell lines that stably overexpressed ZNF671 and knocked down ZNF671 expression to explore its function in NPC in vitro and in vivo...
October 19, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29052451/sesquiterpenes-and-lignans-from-the-flower-buds-of-daphne%C3%A2-genkwa-and-their-nitric-oxide-inhibitory-activities
#11
Chun-Yang Zhang, Lan Luo, Jing Xia, Ya-Nan Song, Li-Jun Zhang, Miao Zhang, Khalid Rahman, Yin Ye, Hong Zhang, Jian-Yong Zhu
Chemical investigation of the Daphne genkwa has led to the isolation of four sesquiterpenes (1a/1b, 2 and 3), including one pair of sesquiterpene enantiomers (1a/1b), 1a is a new compound (+)-4-hydroxy-10-epirotundone, and twelve lignans (4-15). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1a/1b were determined by CD analysis. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, and compounds 7-10 exhibited pronounced inhibition on NO production with IC50 values in the range of 5...
October 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29051064/harnessing-the-cross-talk-between-tumor-cells-and-tumor-associated-macrophages-with-a-nano-drug-for-modulation-of-glioblastoma-immune-microenvironment
#12
Tong-Fei Li, Ke Li, Chao Wang, Xin Liu, Yu Wen, Yong-Hong Xu, Quan Zhang, Qiu-Ya Zhao, Ming Shao, Yan-Ze Li, Min Han, Naoki Komatsu, Li Zhao, Xiao Chen
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The presence of a large population of macrophages (Mφ) in the tumor microenvironment is a prominent feature of GBM and these so-called tumor-associated Mφ (TAM) closely interact with the GBM cells to promote the survival, progression and therapy resistance of the GBM. Various therapeutic strategies have been devised either targeting the GBM cells or the TAM but few have addressed the cross-talks between the two cell populations...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29050755/applied-multiplex-allele-specific-pcr-to-detect-second-line-drug-resistance-among-multidrug-resistant-tuberculosis-in-china
#13
Ya-Ping Liang, Yan Chen, Tong-Yang Xiao, Qiang Xia, Hai-Can Liu, Xiu-Qin Zhao, Chun-Yan Zeng, Li-Li Zhao, Kang-Lin Wan
Rapid detection of resistance to the second-line drugs is essential for early initiation of appropriate anti-tubercular treatment regimen among multi-drug tuberculosis (MDR-TB). In this study, we applied a multiplex allele-specific PCR (MAS-PCR) to identify the mutations on codons 90 and 94 of gyrA and nucleotide 1401 of rrs for detecting ofloxacin (OFX) and kanamycin (KAN) resistance in 139 MDR-TB isolates from China. Using the traditional phenotypic method as the reference, MAS-PCR detected resistance to OFX and KAN with sensitivities of 67...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050616/from-2d-to-3d-the-morphology-proliferation-and-differentiation-of-mc3t3-e1-on-silk-fibroin-chitosan-matrices
#14
Da-Wei Li, Feng-Li He, Jin He, Xudong Deng, Ya-Li Liu, Yang-Yang Liu, Ya-Jing Ye, Da-Chuan Yin
It has been widely accepted that cell culture in two-dimensional (2D) conditions may not be able to represent growth in three-dimensional (3D) conditions. Systematic comparisons between 2D and 3D cell cultures are needed to appropriately use the existing 2D results. In this work, we conducted a comparative study between 2D and 3D cell cultures of MC3T3-E1 using the same type of material (a mixture of silk fibroin (SF) and chitosan (CS)). Our results showed 3D SF/CS scaffold exhibited different effects on cell culture compared with the 2D cases...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050209/handgrip-strength-and-subclinical-carotid-atherosclerosis-in-relation-to-platelet-levels-among-hypertensive-elderly-japanese
#15
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Keita Inoue, Yasuhiro Nagata, Takahiro Maeda
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050003/cantharidin-inhibits-the-growth-of-triple-negative-breast-cancer-cells-by-suppressing-autophagy-and-inducing-apoptosis-in-vitro-and-in-vivo
#16
Hong-Chang Li, Zhi-Hua Xia, Ya-Feng Chen, Fan Yang, Wen Feng, Han Cai, Yi Mei, Yi-Ming Jiang, Ke Xu, Dian-Xu Feng
BACKGROUND/AIMS: Cantharidin, a type of terpenoid secreted by the blister beetle Mylabris phalerata (Pallas), has attracted great attention in cancer therapy because of its potential anti-cancer activities. Here, we report the effects on apoptosis and autophagy in human triple-negative breast cancer (TNBC) cell lines after treatment with cantharidin and attempt to elucidate the underlying mechanisms. METHODS: MDA-MB-231 and MDA-MB-468 cells were treated with cantharidin and cell proliferation was examined using CCK-8 and clone formation assays...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049886/structure-activity-relationship-studies-of-pyrimido-5-4-b-indoles-as-selective-toll-like-receptor-4-ligands
#17
Michael Chan, Yuhei Kakitsubata, Tomoko Hayashi, Alast Ahmadi, Shiyin Yao, Nikunj M Shukla, Shin-Ya Oyama, Akihito Baba, Brandon Nguyen, Maripat Corr, Yasuo Suda, Dennis A Carson, Howard B Cottam, Masahiro Wakao
Previous high throughput screening studies led to the discovery of two novel, non-lipid-like chemotypes as Toll-like receptor 4 (TLR4) agonists. One of these chemotypes, the pyrimido[5,4-b]indoles, was explored for structure-activity relationship trends relative to production of TLR4 dependent cytokines/chemokines resulting in a semi-optimized lead (compound 1) that provided a starting point for further optimization studies. In this report, compounds belonging to three areas of structural modification were evaluated for biological activity using murine and human TLR4 reporter cells, primary murine bone marrow derived dendritic cells, and human peripheral blood mononuclear cells...
October 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29049313/study-on-association-of-working-hours-and-occupational-physical-activity-with-the-occurrence-of-coronary-heart-disease-in-a-chinese-population
#18
Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Hao-Jie Shi, Hao Wang, Mohammad Reeaze Khurwolah, Ya-Fei Li, Zhi-Yong Xie, Yang Yang, Lian-Sheng Wang
OBJECTIVE: To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population. METHODS: A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD...
2017: PloS One
https://www.readbyqxmd.com/read/29049194/effects-of-action-observation-therapy-on-upper-extremity-function-daily-activities-and-motion-evoked-potential-in-cerebral-infarction-patients
#19
Jianming Fu, Ming Zeng, Fang Shen, Yao Cui, Meihong Zhu, Xudong Gu, Ya Sun
BACKGROUND: The aim of this study was to explore the effects of action observation therapy on motor function of upper extremity, activities of daily living, and motion evoked potential in cerebral infarction patients. METHOD: Cerebral infarction survivors were randomly assigned to an experimental group (28 patients) or a control group (25 patients). The conventional rehabilitation treatments were applied in both groups, but the experimental group received an additional action observation therapy for 8 weeks (6 times per week, 20 minutes per time)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048623/vegfr3-inhibition-chemosensitizes-lung-adenocarcinoma-a549-cells-in-the-tumor-associated-macrophage-microenvironment-through-upregulation-of-p53-and-pten
#20
Ya Li, Yaguang Weng, Liang Zhong, Huimin Chong, Sicheng Chen, Yanting Sun, Wang Li, Qiong Shi
In lung adenocarcinoma, loss of p53 and PTEN in tumors are associated with decreased response to chemotherapy and decreased survival. A means to pharmacologically upregulate p53 and PTEN protein expression could improve the prognosis of patients with p53- and PTEN-deficient tumors. In the present study we revealed that vascular endothelial growth factor receptor 3 (VEGFR3) inhibition in lung adenocarcinoma cells was associated with improved expression levels of both p53 and PTEN in the tumor-associated macrophage (TAM) microenvironment...
September 19, 2017: Oncology Reports
keyword
keyword
69826
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"