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https://www.readbyqxmd.com/read/29093543/a-study-of-the-brain-functional-network-of-post-stroke-depression-in-three-different-lesion-locations
#1
Yu Shi, Yanyan Zeng, Lei Wu, Ziping Liu, Shanshan Zhang, Jianming Yang, Wen Wu
Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the brain response of PSD in three different lesions. The brain responses of the three PSD subgroups were similar. However, each subgroup had its own characteristics of the brain network. In the temporal lobe subgroup, the right thalamus had increased degree centrality (DC) values which were different from the other two subgroups...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29049297/functional-connectivity-structure-of-cortical-calcium-dynamics-in-anesthetized-and-awake-mice
#2
Patrick W Wright, Lindsey M Brier, Adam Q Bauer, Grant A Baxter, Andrew W Kraft, Matthew D Reisman, Annie R Bice, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver
The interplay between hemodynamic-based markers of cortical activity (e.g. fMRI and optical intrinsic signal imaging), which are an indirect and relatively slow report of neural activity, and underlying synaptic electrical and metabolic activity through neurovascular coupling is a topic of ongoing research and debate. As application of resting state functional connectivity measures is extended further into topics such as brain development, aging and disease, the importance of understanding the fundamental physiological basis for functional connectivity will grow...
2017: PloS One
https://www.readbyqxmd.com/read/29038494/a-study-of-the-brain-abnormalities-of-post-stroke-depression-in-frontal-lobe-lesion
#3
Yu Shi, Yanyan Zeng, Lei Wu, Wei Liu, Ziping Liu, Shanshan Zhang, Jianming Yang, Wen Wu
Post stroke depression (PSD) is a serious complication of stroke. Brain imaging is an important method of studying the mechanism of PSD. However, few studies have focused on the single lesion location. The aim of this study was to investigate the brain mechanism of frontal lobe PSD using combined voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI). In total, 30 first-time ischemic frontal lobe stroke patients underwent T1 weighted MRI and resting-state fMRI scans. Clinical assessments included the 24-item Hamilton Rating Scale for Depression, the National Institutes of Health Stroke Scale, and the Mini-Mental State Examination...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992948/the-potential-of-real-time-fmri-neurofeedback-for-stroke-rehabilitation-a-systematic-review
#4
Tianlu Wang, Dante Mantini, Celine R Gillebert
Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback aids the modulation of neural functions by training self-regulation of brain activity through operant conditioning. This technique has been applied to treat several neurodevelopmental and neuropsychiatric disorders, but its effectiveness for stroke rehabilitation has not been examined yet. Here, we systematically review the effectiveness of rt-fMRI neurofeedback training in modulating motor and cognitive processes that are often impaired after stroke...
September 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28981635/linking-entropy-at-rest-with-the-underlying-structural-connectivity-in-the-healthy-and-lesioned-brain
#5
Victor M Saenger, Adrián Ponce-Alvarez, Mohit Adhikari, Patric Hagmann, Gustavo Deco, Maurizio Corbetta
The brain is a network that mediates information processing through a wide range of states. The extent of state diversity is a reflection of the entropy of the network. Here we measured the entropy of brain regions (nodes) in empirical and modeled functional networks reconstructed from resting state fMRI to address the connection of entropy at rest with the underlying structure measured through diffusion spectrum imaging. Using 18 empirical and 18 modeled stroke networks, we also investigated the effect that focal lesions have on node entropy and information diffusion...
July 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28981541/contrasting-resting-state-fmri-abnormalities-from-sickle-and-non-sickle-anemia
#6
Julie Coloigner, Yeun Kim, Adam Bush, Soyoung Choi, Melissa C Balderrama, Thomas D Coates, Sharon H O'Neil, Natasha Lepore, John C Wood
Sickle cell disease (SCD) is a chronic blood disorder that is often associated with acute and chronic cerebrovascular complications, including strokes and impaired cognition. Using functional resting state magnetic resonance images, we performed whole-brain analysis of the amplitude of low frequency fluctuations (ALFF), to detect areas of spontaneous blood oxygenation level dependent signal across brain regions. We compared the ALFF of 20 SCD patients to that observed in 19 healthy, age and ethnicity-matched, control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28971011/structurofunctional-resting-state-networks-correlate-with-motor-function-in-chronic-stroke
#7
Benjamin T Kalinosky, Reivian Berrios Barillas, Brian D Schmit
PURPOSE: Motor function and recovery after stroke likely rely directly on the residual anatomical connections in the brain and its resting-state functional connectivity. Both structural and functional properties of cortical networks after stroke are revealed using multimodal magnetic resonance imaging (MRI). Specifically, functional connectivity MRI (fcMRI) can extract functional networks of the brain at rest, while structural connectivity can be estimated from white matter fiber orientations measured with high angular-resolution diffusion imaging (HARDI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28962104/altered-functional-connectivity-in-patients-with-post-stroke-memory-impairment-a-resting-fmri-study
#8
Jiao Liu, Qin Wang, Feiwen Liu, Haiyan Song, Xiaofeng Liang, Zhengkun Lin, Wenjun Hong, Shanli Yang, Jia Huang, Guohua Zheng, Jing Tao, Li-Dian Chen
Post-stroke memory dysfunction (PMD) is one of the most common forms of cognitive impairment among stroke survivors. However, only a limited number of studies have directly investigated the neural mechanisms associated with memory decline. The aim of the present study was to identify dynamic changes in the functional organization of the default mode network (DMN) and the dorsal attention network of patients with PMD. A total of 27 patients with PMD who experienced a stroke in the right hemisphere were enrolled in the current study, along with 27 healthy control subjects matched by age, sex, and educational level...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28961522/linking-left-hemispheric-tissue-preservation-to-fmri-language-task-activation-in-chronic-stroke-patients
#9
Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski
The preservation of near-typical function in distributed brain networks is associated with less severe deficits in chronic stroke patients. However, it remains unclear how task-evoked responses in networks that support complex cognitive functions such as semantic processing relate to the post-stroke brain anatomy. Here, we used recently developed methods for the analysis of multimodal MRI data to investigate the relationship between regional tissue concentration and functional MRI activation evoked during auditory semantic decisions in a sample of 43 chronic left hemispheric stroke patients and 43 age, handedness, and sex-matched controls...
November 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28958737/changes-in-spectroscopic-biomarkers-after-transcranial-direct-current-stimulation-in-children-with-perinatal-stroke
#10
Helen L Carlson, Patrick Ciechanski, Ashley D Harris, Frank P MacMaster, Adam Kirton
BACKGROUND: Perinatal stroke causes lifelong motor disability, affecting independence and quality of life. Non-invasive neuromodulation interventions such as transcranial direct current stimulation (tDCS) combined with intensive therapy may improve motor function in adult stroke hemiparesis but is under-explored in children. Measuring cortical metabolites with proton magnetic resonance spectroscopy (MRS) can inform cortical neurobiology in perinatal stroke but how these change with neuromodulation is yet to be explored...
September 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28928708/neural-patterns-of-reorganization-after-intensive-robot-assisted-virtual-reality-therapy-and-repetitive-task-practice-in-patients-with-chronic-stroke
#11
Soha Saleh, Gerard Fluet, Qinyin Qiu, Alma Merians, Sergei V Adamovich, Eugene Tunik
Several approaches to rehabilitation of the hand following a stroke have emerged over the last two decades. These treatments, including repetitive task practice (RTP), robotically assisted rehabilitation and virtual rehabilitation activities, produce improvements in hand function but have yet to reinstate function to pre-stroke levels-which likely depends on developing the therapies to impact cortical reorganization in a manner that favors or supports recovery. Understanding cortical reorganization that underlies the above interventions is therefore critical to inform how such therapies can be utilized and improved and is the focus of the current investigation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28917165/cerebellar-induced-differential-polyglot-aphasia-a-neurolinguistic-and-fmri-study
#12
Peter Mariën, Kim van Dun, Johanna Van Dormael, Dorien Vandenborre, Stefanie Keulen, Mario Manto, Jo Verhoeven, Jubin Abutalebi
Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebellum remains largely unexplored. This paper reports the clinical and fMRI findings in a strongly right-handed (late) multilingual patient who developed differential polyglot aphasia, ataxic dysarthria and a selective decrease in executive function due to an ischemic stroke in the left cerebellum...
September 13, 2017: Brain and Language
https://www.readbyqxmd.com/read/28914232/combined-rtms-and-virtual-reality-brain-computer-interface-training-for-motor-recovery-after-stroke
#13
Nessa N Johnson, James Carey, Bradley Edelman, Alexander Doud, Andrew Grande, Kamakshi Lakshminarayan, Bin He
OBJECTIVE: Combining repetitive transcranial magnetic stimulation (rTMS) with brain-computer interface (BCI) training can address motor impairment after stroke by down-regulating exaggerated inhibition from the contralesional hemisphere and encouraging ipsilesional activation. The objective was to evaluate the efficacy of combined rTMS+BCI, compared to sham rTMS+BCI, on motor recovery after stroke in subjects with lasting motor paresis. APPROACH: Three stroke subjects approximately one year post-stroke participated in three weeks of combined rTMS (real or sham) and BCI, followed by three weeks of BCI alone...
September 15, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28900231/functional-neural-changes-associated-with-acquired-amusia-across-different-stages-of-recovery-after-stroke
#14
Aleksi J Sihvonen, Teppo Särkämö, Pablo Ripollés, Vera Leo, Jani Saunavaara, Riitta Parkkola, Antoni Rodríguez-Fornells, Seppo Soinila
Brain damage causing acquired amusia disrupts the functional music processing system, creating a unique opportunity to investigate the critical neural architectures of musical processing in the brain. In this longitudinal fMRI study of stroke patients (N = 41) with a 6-month follow-up, we used natural vocal music (sung with lyrics) and instrumental music stimuli to uncover brain activation and functional network connectivity changes associated with acquired amusia and its recovery. In the acute stage, amusic patients exhibited decreased activation in right superior temporal areas compared to non-amusic patients during instrumental music listening...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875598/recovery-of-proprioception-in-the-upper-extremity-by-robotic-mirror-therapy-a-clinical-pilot-study-for-proof-of-concept
#15
Hyung Seok Nam, Sukgyu Koh, Jaewon Beom, Yoon Jae Kim, Jang Woo Park, Eun Sil Koh, Sun Gun Chung, Sungwan Kim
A novel robotic mirror therapy system was recently developed to provide proprioceptive stimulus to the hemiplegic arm during a mirror therapy. Validation of the robotic mirror therapy system was performed to confirm its synchronicity prior to the clinical study. The mean error angle range between the intact arm and the robot was 1.97 to 4.59 degrees. A 56-year-old male who had right middle cerebral artery infarction 11 months ago received the robotic mirror therapy for ten 30-minute sessions during 2 weeks...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28830824/a-structural-motor-network-correlates-with-motor-function-and-not-impairment-post-stroke
#16
Sue Peters, Katie P Wadden, Kathryn S Hayward, Jason L Neva, Angela M Auriat, Lara A Boyd
Combining structural and functional magnetic resonance imaging may provide insight into how residual motor networks contribute to motor outcomes post-stroke. The purpose of this study was to examine whether a structural motor network (SMN), generated with fMRI guided diffusion-based tractography, relates to motor function post-stroke. Twenty-seven individuals with mild to moderate upper limb impairment post stroke underwent diffusion magnetic resonance imaging. A bilateral motor network mask guided white matter tractography for each participant...
September 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28796033/rtms-treatments-combined-with-speech-training-for-a-conduction-aphasia-patient-a-case-report-with-mri-study
#17
Hui Zhang, Ying Chen, Ruiping Hu, Liqing Yang, Mengxing Wang, Jilei Zhang, Haifeng Lu, Yi Wu, Xiaoxia Du
RATIONALE: To date, little is known regarding the neural mechanisms of the functional recovery of language after repetitive transcranial magnetic stimulation (rTMS) in aphasia. Our aim was to investigate the mechanism that underlies rTMS and speech training in a case report. PATIENT CONCERNS AND DIAGNOSES: We report the case of a 39-year-old woman who was initially diagnosed with conduction aphasia following a left hemisphere stroke. INTERVENTIONS: The rTMS location comprised the left Broca area, and a frequency of 5 Hz for 20 min/d for 10 days during a 2-week period was used...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28794972/fractional-amplitude-of-low-frequency-fluctuations-falff-in-post-stroke-depression
#18
Natalia Egorova, Michele Veldsman, Toby Cumming, Amy Brodtmann
Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28794427/neuroimaging-biomarkers-to-associate-obesity-and-negative-emotions
#19
Bo-Yong Park, Jisu Hong, Hyunjin Park
Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explored. We obtained 196 emotion task functional magnetic resonance imaging (t-fMRI) from the Human Connectome Project database using a sampling scheme similar to a bootstrapping approach. Brain regions were specified by automated anatomical labeling atlas and the brain activity (z-statistics) of each brain region was correlated with body mass index (BMI) values...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782545/reshaping-the-brain-after-stroke-the-effect-of-prismatic-adaptation-in-patients-with-right-brain-damage
#20
Sonia Crottaz-Herbette, Eleonora Fornari, Michael P Notter, Claire Bindschaedler, Laura Manzoni, Stephanie Clarke
Prismatic adaptation has been repeatedly reported to alleviate neglect symptoms; in normal subjects, it was shown to enhance the representation of the left visual space within the left inferior parietal cortex. Our study aimed to determine in humans whether similar compensatory mechanisms underlie the beneficial effect of prismatic adaptation in neglect. Fifteen patients with right hemispheric lesions and 11 age-matched controls underwent a prismatic adaptation session which was preceded and followed by fMRI using a visual detection task...
September 2017: Neuropsychologia
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