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fMRI stroke

Monica Baciu, Audrey Acher, Louise Kauffmann, Emilie Cousin, Claire Boilley, Thomas Hueber, Pierre Badin, Pascal Perrier, Diandra Fabre, Assia Jaillard, Olivier Detante, Dominique Perennou
OBJECTIVE: To assess the efficiency of Visual Feedback (VF) on language recovery and plasticity in three chronic non-fluent aphasic patients. VF is based on language-action interaction, thus, language skills are improved by rehabilitation strategies based on execution and observation of motor actions. VF is an ultrasound system coupled with video images, allowing patients to 'see their own lips and tongue at work' during speech and improve their awareness of their lingual and labial movements and their ability to coordinate and combine phonemes and syllables...
September 2016: Annals of Physical and Rehabilitation Medicine
Annelise Raillon Moulinet, Lucie Chochina, Stéphanie Challois Leplaideur, Elise Bannier, Jean-Christophe Ferre, Isabelle Bonan
OBJECTIVE: Subjects use different referentials for spatial localization, and the egocentric references are very often impaired especially during stroke. The objective is to find the difference between activations induced by 2 egocentric tasks MATERIAL/PATIENTS AND METHODS: Seventeen right-handed healthy subjects (50.4±14.9 years) were tested using fMRI during the realization of 2 egocentric spatial tasks: the perception of the straight ahead (retinocentric) and the longitudinal axis of the body (centered by the trunk)...
September 2016: Annals of Physical and Rehabilitation Medicine
Liesjet Van Dokkum, Emmanuelle Le Bars, Denis Mottet, Alain Bonafe, Nicolas Menjot de Champfleur, Isabelle Laffont
OBJECTIVE: After stroke, the less affected upper-limb shows slight but substantial and longterm motor deficits [1]. Kinematically, this is reflected by an increased segmentation of movements. Here, we aim to define how these changes in behavior are accompanied by changes in brain activation. MATERIAL/PATIENTS AND METHODS: Twenty-one sub-acute post-stroke patients with a first-ever unilateral ischemic stroke of the middle cerebral artery participated in this study twice: within the first 6 weeks post-stroke and after 6 weeks of rehabilitation...
September 2016: Annals of Physical and Rehabilitation Medicine
Kyle R Biesecker, Anja I Srienc, Angela M Shimoda, Amit Agarwal, Dwight E Bergles, Paulo Kofuji, Eric A Newman
UNLABELLED: The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca(2+) increases in glial cells, triggering glial release of vasodilating agents. This hypothesis has been challenged, as arteriole dilation can occur in the absence of glial Ca(2+) signaling. We address this controversy by imaging glial Ca(2+) signaling and vessel dilation in the mouse retina. We find that sensory stimulation results in Ca(2+) increases in the glial endfeet contacting capillaries, but not arterioles, and that capillary dilations often follow spontaneous Ca(2+) signaling...
September 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jane M Rondina, Maurizio Filippone, Mark Girolami, Nick S Ward
Clinical research based on neuroimaging data has benefited from machine learning methods, which have the ability to provide individualized predictions and to account for the interaction among units of information in the brain. Application of machine learning in structural imaging to investigate diseases that involve brain injury presents an additional challenge, especially in conditions like stroke, due to the high variability across patients regarding characteristics of the lesions. Extracting data from anatomical images in a way that translates brain damage information into features to be used as input to learning algorithms is still an open question...
2016: NeuroImage: Clinical
Sara A Rafique, John R Richards, Jennifer K E Steeves
OBJECTIVE: To investigate the efficacy of multiday repetitive transcranial magnetic stimulation (rTMS) to the occipital cortex in a patient with continuous visual phosphene hallucinations for more than 2 years following occipital stroke. METHODS: Low-frequency rTMS (1 Hz) was applied to the lesion site for 30 minutes daily over 5 consecutive days. Functional MRI (fMRI) was performed before and after rTMS treatment. RESULTS: Increased application of rTMS corresponded with a reduction in intensity of visual phosphene hallucinations and was reflected in altered blood oxygen level-dependent signal...
October 4, 2016: Neurology
Maite Termenon, Sophie Achard, Assia Jaillard, Chantal Delon-Martin
Stroke, resulting in focal structural damage, induces changes in brain function at both local and global levels. Following stroke, cerebral networks present structural, and functional reorganization to compensate for the dysfunctioning provoked by the lesion itself and its remote effects. As some recent studies underlined the role of the contralesional hemisphere during recovery, we studied its role in the reorganization of brain function of stroke patients using resting state fMRI and graph theory. We explored this reorganization using the "hub disruption index" (κ), a global index sensitive to the reorganization of nodes within the graph...
2016: Frontiers in Computational Neuroscience
Emiri T Mandeville, Cenk Ayata, Yi Zheng, Joseph B Mandeville
Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies...
August 31, 2016: Translational Stroke Research
Csilla Vér, Miklós Emri, Tamás Spisák, Ervin Berényi, Kázmér Kovács, Péter Katona, László Balkay, László Menyhárt, László Kardos, László Csiba
BACKGROUND: This study aims at investigating the short-term efficacy of the continuous passive motion (CPM) device developed for the therapy of ankle-foot paresis and to investigate by fMRI the blood oxygen level-dependent responses (BOLD) during ankle passive movement (PM). METHODS: Sixty-four stroke patients were investigated. Patients were assigned into 2 groups: 49 patients received both 15 min manual and 30 min device therapy (M + D), while the other group (n = 15) received only 15 min manual therapy (M)...
August 31, 2016: European Neurology
Evelyn M R Lake, Paolo Bazzigaluppi, Bojana Stefanovic
Ischaemic stroke is the leading cause of adult disability worldwide. Effective rehabilitation is hindered by uncertainty surrounding the underlying mechanisms that govern long-term ischaemic injury progression. Despite its potential as a sensitive non-invasive in vivo marker of brain function that may aid in the development of new treatments, blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has found limited application in the clinical research on chronic stage stroke progression...
October 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Vladislav Balaev, Alexey Petruchevsky, Olga Martynova
To evaluate the influence of post-stroke aphasia on the functional association of widespread largescale neuronal networks, we analyzed functional connectivity between resting state brain networks (RSNs) in aphasic patients (N = 15) and in healthy volunteers (N = 17) of the same age using resting state fMRI. As a result, six RSNs were isolated and cross-correlation matrices were computed for their time courses. Aphasic patients showed decreased correlations between posterior part of the default mode (pDMN) and both auditory (AUD) and right frontoparietal (RFP) networks...
August 10, 2016: Brain Connectivity
Bokkyu Kim, Carolee Winstein
Background There is growing interest to establish recovery biomarkers, especially neurological biomarkers, in order to develop new therapies and prediction models for the promotion of stroke rehabilitation and recovery. However, there is no consensus among the neurorehabilitation community about which biomarker(s) have the highest predictive value for motor recovery. Objective To review the evidence and determine which neurological biomarker(s) meet the high evidence quality criteria for use in predicting motor recovery...
August 8, 2016: Neurorehabilitation and Neural Repair
Cathy J Price, Thomas T M Hope, Mohamed L Seghier
In this paper, we consider solutions to ten of the challenges faced when trying to predict an individual's functional outcome after stroke on the basis of lesion site. A primary goal is to find lesion-outcome associations that are consistently observed in large populations of stroke patients because consistent associations maximise confidence in future individualised predictions. To understand and control multiple sources of inter-patient variability, we need to systematically investigate each contributing factor and how each factor depends on other factors...
August 5, 2016: NeuroImage
Christof Karmonik, Anthony Brandt, Jeff Anderson, Forrest Brooks, Julie Lytle, Elliott Silverman, Jeff T Frazier
Listening to familiar music has recently been reported to be beneficial during recovery from stroke. A better understanding of changes in functional connectivity and information flow is warranted in order to further optimize and target this approach through music therapy. Twelve healthy volunteers listened to seven different auditory samples during an fMRI scanning session: a musical piece chosen by the volunteer that evokes a strong emotional response (referred to as: "self-selected emotional"), two unfamiliar music pieces (Invention #1 by J...
July 27, 2016: Brain Connectivity
Cheng-Yu Peng, Yu-Chen Chen, Ying Cui, Deng-Ling Zhao, Yun Jiao, Tian-Yu Tang, Shenghong Ju, Gao-Jun Teng
OBJECTIVES: Post-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence in patients after subcortical stroke. METHODS: Resting-state fMRI measurements were acquired from 16 post-stroke patients with poor cognitive function (PSPC), 16 post-stroke patients with good cognitive function (PSGC) and 30 well-matched healthy controls (HC)...
2016: PloS One
Ryan V Raut, Veena A Nair, Justin A Sattin, Vivek Prabhakaran
Functional MRI (fMRI) is well-established for the study of brain function in healthy populations, although its clinical application has proven more challenging. Specifically, cerebrovascular reactivity (CVR), which allows the assessment of the vascular response that serves as the basis for fMRI, has been shown to be reduced in healthy aging as well as in a range of diseases, including chronic stroke. However, the timing of when this occurs relative to the stroke event is unclear. We used a breath-hold fMRI task to evaluate CVR across gray matter in a group of acute stroke patients (< 10 days from stroke; N = 22) to address this question...
2016: NeuroImage: Clinical
Massimo Filippi, Federica Agosta
The advances in diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and functional magnetic resonance imaging (fMRI) over the last 20 years have vastly contributed to improving the understanding of the brain structure and function in patients with many diseases of the central nervous system (CNS). DWI is commonly used, for instance, in the diagnostic workup of stroke, CNS neoplasia, and rapidly progressive dementia cases. The new DTI methods provide more specific information about the most destructive aspects of tumors, neurodegenerative dementia, and multiple sclerosis pathology and give a more complete picture of the complex pathologic mechanisms of these conditions...
2016: Handbook of Clinical Neurology
Jing Li, Xue-Wei Zhang, Zhen-Tao Zuo, Jie Lu, Chun-Ling Meng, Hong-Ying Fang, Rong Xue, Yong Fan, Yu-Zhou Guan, Wei-Hong Zhang
AIMS: Our study aimed to figure out brain functional reorganization evidence after repetitive transcranial magnetic stimulation (rTMS) using the resting-state functional magnetic resonance imaging (rsfMRI). METHODS: Twelve patients with unilateral subcortex lesion in the middle cerebral artery territory were recruited. Seven of them received a 10-day rTMS treatment beginning at about 5 days after stroke onset. The remaining five received sham treatment. RsfMRI and motor functional scores were obtained before and after rTMS or sham rTMS...
July 15, 2016: CNS Neuroscience & Therapeutics
S Badoud, S Borgognon, J Cottet, P Chatagny, V Moret, M Fregosi, M Kaeser, E Fortis, E Schmidlin, J Bloch, J F Brunet, E M Rouiller
In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the "modified-Brinkman board" task and the "reach and grasp drawer" task. The aim of the present study was to extend preliminary data on the role of the prefrontal cortex in motor habit and test the hypothesis that dlPFC contributes to predict the grip force required when a precise level of force to be generated is known beforehand...
July 9, 2016: Brain Structure & Function
Leeanne M Carey, David F Abbott, Gemma Lamp, Aina Puce, Rüdiger J Seitz, Geoffrey A Donnan
BACKGROUND: The brain may reorganize to optimize stroke recovery. Yet relatively little is known about neural correlates of training-facilitated recovery, particularly after loss of body sensations. OBJECTIVE: Our aim was to characterize changes in brain activation following clinically effective touch discrimination training in stroke patients with somatosensory loss after lesions of primary/secondary somatosensory cortices or thalamic/capsular somatosensory regions using functional magnetic resonance imaging (fMRI)...
June 20, 2016: Neurorehabilitation and Neural Repair
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