Emma A Koemans, Ingeborg Rasing, Sabine Voigt, Thijs W van Harten, Reinier G J van der Zwet, Kanishk Kaushik, Manon R Schipper, Nelleke van der Weerd, Erik W van Zwet, Ellis S van Etten, Matthias J P van Osch, Bea Kuiperij, Marcel M Verbeek, Gisela M Terwindt, Steven M Greenberg, Marianne A A van Walderveen, Marieke J H Wermer
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. We investigated the presence and abnormality of the most common biomarkers in the largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: We included cross-sectional data from participants with (pre)symptomatic D-CAA and controls without CAA. We investigated CAA-related cerebral small vessel disease markers on 3T-MRI, cerebrovascular reactivity with functional 7T-MRI (fMRI) and amyloid-β40 and amyloid-β42 levels in cerebrospinal fluid...
March 6, 2024: Stroke; a Journal of Cerebral Circulation