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https://www.readbyqxmd.com/read/29144103/effects-of-home-based-superimposed-neuromuscular-electrical-stimulation-in-severe-chronic-obstructive-pulmonary-disease-patients-a-randomized-controlled-clinical-trial
#1
Marie C Valenza, Irene Torres-Sánchez, Laura López-López, Irene Cabrera-Martos, Araceli Ortiz-Rubio, Gerald Valenza-Demet
BACKGROUND: COPD patients experience a sustained deterioration of several capacities. Those with severe COPD undergo a considerable decline in their physical and functional capacities, but pulmonary rehabilitation (PR) is used to reduce the weakness of such patients. To date, neuromuscular electrical stimulation (NMES) has been used in acute COPD patients but NMES superimposed onto voluntary muscular contraction has not been tested in COPD patients. AIM: The aim of this study was to evaluate the effects of superimposed NMES on the cardiorespiratory performance and functionality of severe COPD patients undergoing a home-based rehabilitation program...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29141087/effect-of-granulocyte-macrophage-colony-stimulating-factor-with-or-without-supervised-exercise-on-walking-performance-in-patients-with-peripheral-artery-disease-the-propel-randomized-clinical-trial
#2
Mary M McDermott, Luigi Ferrucci, Lu Tian, Jack M Guralnik, Donald Lloyd-Jones, Melina R Kibbe, Tamar S Polonsky, Kathryn Domanchuk, James H Stein, Lihui Zhao, Doris Taylor, Christopher Skelly, William Pearce, Harris Perlman, Walter McCarthy, Lingyu Li, Ying Gao, Robert Sufit, Christina L Bloomfield, Michael H Criqui
Importance: Benefits of granulocyte-macrophage colony-stimulating factor (GM-CSF) for improving walking ability in people with lower extremity peripheral artery disease (PAD) are unclear. Walking exercise may augment the effects of GM-CSF in PAD, since exercise-induced ischemia enhances progenitor cell release and may promote progenitor cell homing to ischemic calf muscle. Objectives: To determine whether GM-CSF combined with supervised treadmill exercise improves 6-minute walk distance, compared with exercise alone and compared with GM-CSF alone; to determine whether GM-CSF alone improves 6-minute walk more than placebo and whether exercise improves 6-minute walk more than an attention control intervention...
November 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29140923/il-4-mediates-the-analgesia-produced-by-low-intensity-exercise-in-mice-with-neuropathic-pain
#3
Franciane Bobinski, Juliana Maia Teixeira, Kathleen Anne Sluka, Adair Roberto Soares Santos
Peripheral nerve injury (PNI) activates the immune system resulting in increased pro-inflammatory cytokines at the site of injury and in the spinal cord dorsal horn. Exercise modulates the immune system promoting an anti-inflammatory phenotype of macrophages in uninjured muscle, and increases in anti-inflammatory cytokines can promote healing and analgesia. We proposed that PNI will decrease, and treadmill exercise will increase, release of anti-inflammatory cytokines at the site of injury and in the spinal cord...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140137/v%C3%AC-o2-and-muscle-deoxygenation-kinetics-during-skating-comparison-between-slide-board-and-treadmill-skating
#4
Tatiane Piucco, Rogério Soares, Fernando Diefenthaeler, Guillaume Millet, Juan Murias
PURPOSE: this study aimed to compare the oxygen uptake (V̇O2) kinetics during skating on a treadmill and skating on a slide board and discuss potential mechanisms that might control the V̇O2 kinetics responses during skating. METHODS: breath-by-breath pulmonary V̇O2 and near-infrared spectroscopy-derived muscle deoxygenation ([HHbMb]) were monitored continuously in 12 well-trained young long track speed skaters. On-transient V̇O2 and [HHbMb] responses to skating on a treadmill and skating on a slide board at 80% of the estimated gas exchange threshold were fitted as mono-exponential function...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29135785/comparison-of-polar-m600-optical-heart-rate-and-ecg-heart-rate-during-exercise
#5
John F Horton, Pro Stergiou, Tak S Fung, Larry Katz
PURPOSE: The purpose of this study was to evaluate the accuracy of the Polar M600 optical heart rate (OHR) sensor compared with ECG heart rate (HR) measurement during various physical activities. METHODS: Thirty-six subjects participated in a continuous 76-min testing session, which included rest, cycling warm-up, cycling intervals, circuit weight training, treadmill intervals, and recovery. HR was measured using a three-lead ECG configuration and a Polar M600 Sport Watch on the left wrist...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134470/the-effect-of-long-term-confinement-and-the-efficacy-of-exercise-countermeasures-on-muscle-strength-during-a-simulated-mission-to-mars-data-from-the-mars500-study
#6
Christopher J Gaffney, Elena Fomina, Dennis Babich, Vladimir Kitov, Konstantin Uskov, David A Green
BACKGROUND: Isolation and long duration spaceflight are associated with musculoskeletal deconditioning. Mars500 was a unique, high-fidelity analogue of the psychological challenges of a 520-day manned mission to Mars. We aimed to explore the effect of musculoskeletal deconditioning on three outcome measures: (1) if lower limb muscle strength was reduced during the 520-day isolation; (2) if type I or II muscle fibres were differentially affected; and (3) whether any 70-day exercise interventions prevented any isolation-induced loss of strength...
November 13, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/29132927/whole-exome-sequencing-identified-a-pathogenic-mutation-in-ryr2-in-a-chinese-family-with-unexplained-sudden-death
#7
Yubi Lin, Siqi He, Zili Liao, Ruiling Feng, Ruilin Liu, Yongzheng Peng, Nan Yu, Hang Qi, Jia Chen, Zifeng Huang, Heping Lei, Yang Liu, Fang Rao, Chunyu Deng, Yumei Xue, Guolin Zhang, Bin Zhang, Hua Yao, Shulin Wu
OBJECTIVE: This study aimed to identify the pathogenic mutation in a Chinese family with unexplained sudden death (USD) or occasional syncope. MATERIALS AND METHODS: Whole exome sequencing and target capture sequencing were respectively conducted for two related patients. The genetic data was screened using the 1000 genomes project and SNP database (PubMed), and the identified mutations were assessed for predicted pathogenicity using the SIFT and Polyphen-2 algorithms...
October 10, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29131814/effects-of-an-exercise-protocol-for-improving-handgrip-strength-and-walking-speed-on-cognitive-function-in-patients-with-chronic-stroke
#8
Jaeeun Kim, Jongeun Yim
BACKGROUND Handgrip strength and walking speed predict and influence cognitive function. We aimed to investigate an exercise protocol for improving handgrip strength and walking speed, applied to patients with chronic stroke who had cognitive function disorder. MATERIAL AND METHODS Twenty-nine patients with cognitive function disorder participated in this study, and were randomly divided into one of two groups: exercise group (n=14) and control group (n=15). Both groups underwent conventional physical therapy for 60 minutes per day...
November 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29129676/exercise-enhances-cognitive-function-and-neurotrophin-expression-in-the-hippocampus-accompanied-by-changes-in-epigenetic-programming-in-senescence-accelerated-mice
#9
Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
Aerobic exercise is known to increase expression of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), in the hippocampus and to improve cognitive function. Exercise exerts neuroprotective effects in the hippocampus by inducing epigenetic changes, which play crucial roles in aging and neurodegenerative diseases. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation and modulate gene transcription. The objective of the present study was to assess the interactive effects of exercise and aging on cognitive function, expression of neurotrophins (BDNF and neurotrophin-4) and their receptors (tyrosine receptor kinase B and p75), and epigenetic regulations, including the activity of HATs and HADCs in the hippocampus...
November 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29128320/exercise-decreases-bace-and-app-levels-in-the-hippocampus-of-a-rat-model-of-alzheimer-s-disease
#10
Karim A Alkadhi, An T Dao
We investigated the effect of treadmill exercise training on the levels of Alzheimer's disease (AD)-related protein molecules in the DG and CA1 areas of a rat model of AD, i.c.v. infusion of Aβ1-42 peptide, 2weeks (250pmol/day). Aβ infusion markedly increased protein levels of amyloid precursor protein (APP), the secretase beta-site APP cleaving enzyme-1 (BACE-1) and Aβ in the CA1 and DG areas. The results also revealed that 4weeks of treadmill exercise prevented the increase in the levels of APP, BACE-1 and Aβ proteins in both hippocampal areas...
November 8, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29125056/monosodium-glutamate-and-treadmill-exercise-anxiety-like-behavior-and-spreading-depression-features-in-young-adult-rats
#11
Suênia Marcele Vitor-de-Lima, Larissa de Brito Medeiros, Regina de Deus Lira Benevides, Catarina Nicácio Dos Santos, Nahara Oliveira Lima da Silva, Rubem Carlos Araújo Guedes
OBJECTIVES: The route of administration is an important factor in determining the action of some drugs. We previously demonstrated that subcutaneous monosodium glutamate (MSG) accelerated cortical spreading depression (CSD) in the rat and that treadmill exercise attenuated this effect. This study evaluated whether other routes of administration exert the same action by testing orogastric (gavage) and topical cortical MSG administration in treadmill-exercised and sedentary rats. Additionally, in the orogastric treatment we tested anxiety-like behavior...
November 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29124664/downhill-exercise-alters-immunoproteasome-content-in-mouse-skeletal-muscle
#12
Cory W Baumann, Dongmin Kwak, Deborah A Ferrington, LaDora V Thompson
Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome responds to stressful situations that do not promote large perturbations in skeletal muscle proteolysis. The purpose of this study was to determine how an acute bout of muscular stress influences immunoproteasome content. To accomplish this, wild-type (WT) and immunoproteasome knockout lmp7 (-/-) /mecl1 (-/-) (L7M1) mice were run downhill on a motorized treadmill...
November 9, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29123620/the-effects-of-regular-exercise-on-capsaicin-induced-pulpal-pain-and-pain-induced-changes-in-passive-avoidance-learning-and-memory-in-rats
#13
Maryam Raoof, Afshin Shakoori, Razieh Kooshki, Mehdi Abbasnejad, Sara Amanpour
Background: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to be effective on cognitive function as well as pain processing in the central nervous system. Here, the possible effects of regular exercise on pulpal pain response as well as pain-induced changes in learning and memory efficiency in rats were investigated. Methods: Twenty-four male Wistar rats were randomly assigned to the control, capsaicin, exercise, and exercise plus capsaicin groups...
October 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/29123337/effect-of-aerobic-exercise-on-cancer-related-fatigue
#14
Jaivika Govindbhai Patel, Anjali R Bhise
Background: Fatigue is the most common side effect of cancer treatment with chemotherapy and/or radiation therapy, selected biologic response modifiers. The main purpose of this study is to evaluate the effects of aerobic exercise on cancer-related fatigue in patients of the solid tumor after chemotherapy and radiotherapy. Methods: After screening for cancer-related fatigue, 34 patients fulfilled the inclusive criteria and were assigned into two groups (n = 17 recruited in the intervention group and n = 17 in control group)...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29122708/combinatory-effects-of-phytoestrogens-and-exercise-on-body-fat-mass-and-lipid-metabolism-in-ovariectomized-female-rats
#15
Wenya Zheng, Jana Rogoschin, Anja Niehoff, Kristina Oden, Sabine E Kulling, Mingyong Xie, Patrick Diel
The purpose of this study was to investigate the combinatory effects of an isoflavone (ISO)-rich diet and exercise on fat mass and lipid metabolism in ovariectomized (OVX) rats. Therefore the female Wistar rats were sedentary, performed an intense treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. The exercise reduced visceral fat mass, adipocyte size and serum leptin in Sham animals and antagonized the increases of these parameters induced by OVX. ISOs reduced OVX induced increase of serum leptin...
November 6, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29122139/role-of-exercise-testing-in-hypertrophic%C3%A2-cardiomyopathy
#16
REVIEW
Ethan J Rowin, Barry J Maron, Iacopo Olivotto, Martin S Maron
Over the last 25 years, patients with hypertrophic cardiomyopathy (HCM) have been studied with a variety of methods employing physiological exercise that have made major contributions to disease management and are performed without increased risk. Previously under-utilized in HCM, exercise (stress) echocardiography has become incorporated into the standard clinical assessment and diagnostic armamentarium of HCM using upright or supine symptom-limited treadmill or bicycle modalities. In patients without outflow gradients at rest, exercise echocardiography is the most appropriate method for provoking obstruction, with the capability of predicting future development of progressive heart failure symptoms, and differentiating patients with provocable obstruction from those without obstruction, with major implications for dictating treatment options, that is, surgical myectomy (alternatively, alcohol septal ablation) versus heart transplant...
November 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29119373/additional-value-of-systolic-wall-thickening-in-myocardial-stunning-evaluated-by-stress-rest-gated-perfusion-spect
#17
Alberto Bestetti, Besart Cuko, Adriano Decarli, Alessio Galli, Federico Lombardi
AIM AND PATIENTS: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of (99m)Tc-tetrofosmin after stress and at rest...
November 8, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29118320/nicotinamide-mononucleotide-nmn-supplementation-ameliorates-the-impact-of-maternal-obesity-in-mice-comparison-with-exercise
#18
Golam Mezbah Uddin, Neil A Youngson, Bronte M Doyle, David A Sinclair, Margaret J Morris
Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD(+)). We have shown that the NAD(+) precursor, nicotinamide mononucleotide (NMN) can reverse some of the negative consequences of high fat diet (HFD) consumption. To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116831/clinician-friendly-physical-performance-tests-for-the-knee
#19
Jerrod J Harrison, Marissa K Yorgey, Alexander J Csiernik, Joseph H Vogler, Kenneth E Games
Reference:  Hegedus EJ, McDonough S, Bleakley C, Cook CE, Baxter GD. Clinician-friendly lower extremity physical performance measures in athletes: a systematic review of measurement properties and correlation with injury. Part 1: the tests for knee function including the hop tests. Br J Sports Med. 2015;49(10):642-648. CLINICAL QUESTION:   Do individual physical performance tests (PPTs) used as measures for lower extremity function have any relationship to injuries in athletes aged 12 years or older? DATA SOURCES:   Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to locate articles...
November 8, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29114917/pulmonary-arterial-pressure-detects-functional-mitral-stenosis-after-annuloplasty-for-primary-mitral-regurgitation-an-exercise-stress-echocardiographic-study
#20
Niloufar Samiei, Marzieh Tajmirriahi, Ali Rafati, Yeganeh Pasebani, Yousef Rezaei, Saeid Hosseini
INTRODUCTION: The restrictive mitral valve annuloplasty (RMA) is the treatment of choice for degenerative mitral regurgitation (MR), but postoperative functional mitral stenosis remains a matter of debate. In this study, we sought to determine the impact of mitral stenosis on the functional capacity of patients. METHODS: In a cross-sectional study, 32 patients with degenerative MR who underwent RMA using a complete ring were evaluated. All participants performed treadmill exercise test and underwent echocardiographic examinations before and after exercise...
November 8, 2017: Echocardiography
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