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Nayef E Saadé, Hassen A Al Amin, Jad Barchini, Sima Tchachaghian, Farah Shamaa, Suhayl J Jabbur, Samir F Atweh
Lidocaine injections in the rostral ventromedial medulla (RVM) have been shown to produce significant reduction of neuropathic manifestations in rats. This effect has been attributed to selective block of a pain descending facilitatory system, responsible for chronic pain. However, recent observations from our laboratory did not provide confirmation to this hypothesis. We aimed, therefore, to investigate the spinal synaptic mechanisms activated by lidocaine injections in the RVM. Rats were subjected, under deep anesthesia, to the induction of mononeuropathy on one hindpaw, and to the stereotaxic implantation of chronic cannulae in the RVM for the injection of lidocaine or GABA antagonists...
September 2012: Experimental Neurology
L Simonsen, J Bülow, C Tuxen, N J Christensen
Seven patients with histologically verified small cell lung carcinoma were given an oral glucose load of 75 g on two occasions to examine the effect of glucose on whole body and forearm thermogenesis with and without acute beta-adrenergic inhibition with propranolol. Whole body energy expenditure was measured by the open circuit ventilated hood system. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. The uptake of oxygen in the forearm was calculated as the product of the forearm blood flow and the difference in arteriovenous oxygen concentration...
September 1994: Clinical Physiology
S A Chepurnov, V P Belyĭ
No abstract text is available yet for this article.
July 1974: Neir̆ofiziologiia, Neurophysiology
R E Coupland, D Hopwood
No abstract text is available yet for this article.
April 1966: Journal of Anatomy
V I Kulinskiĭ, R Ia Oloviannikova
A method is developed for estimation of the catecholamine-O-methyl transferase activity in human organism by excretion with urine of unmetabolized isadrine (N-isopropyl noreadrenaline) after loading. Excretion of isadrine was increased both after administration of apomorphine, which is one of the inhibitors of the enzyme catecholamine-O-methyl transferase, and in cases of liver tissue pathology. It is known that the maximal activity of catecholamine-O-methyl transferase is the highest in liver tissue. Imipramine (an inhibitor of uptake of catecholamine) did not inhibit the activity of cafecholamine-O-methyl transferase as estimated by the present method...
September 1976: Voprosy Medit︠s︡inskoĭ Khimii
U Kreisen, C M Büsing
Female rats with a body weight of approximately 200 g regular show necroses of myocardial fibers after subcutaneous injection of 1-Noradrenaline (2.5 mg/kg body weight). After intraperitoneal premedication with Strophanthin k in a therapeutical dosage (2 X 10(-5 g/kg body weight), the increase in number and extent of the necroses is statistically significant. These findings argue against a preventive effect of Strophanthin k and can be explained by the mode of action of catecholamines and glycosides, as both substances, in a like manner, cause an increase in the mobilizable intracellular calcium of the myocardial fiber...
June 23, 1975: Virchows Archiv. A, Pathological Anatomy and Histology
S T Mason, S D Iversen
Selective destruction of the noradrenaline systems in the rat brain using the neurotoxin 6-hydroxydopamine has been found to cause resistance to extinction in a number of behavioural situations. Several theories concerning the behavioural mechanism altered by the lesion, and hence about the role of noradrenaline in normal brain functioning, are proposed and evaluated. Theories suggesting a role for noradrenaline in activity, perseveration, internal inhibition, frustrative non-reward, motivation, or secondary reinforcement, fail to explain all the available evidence and direct tests of each theory fails to support its predictions...
July 1979: Brain Research
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