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CRC AND MICROBIOTA

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https://www.readbyqxmd.com/read/27913126/association-between-parkinson-s-disease-and-risk-of-colorectal-cancer
#1
Xin Xie, Xiaoguang Luo, Mingliang Xie
BACKGROUND: Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis. METHODS: A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016...
November 22, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27902422/microbiota-dysbiosis-a-new-piece-in-the-understanding-of-carcinogenesis-puzzle
#2
Valeria García-Castillo, Enrique Sanhueza, Eileen McNerney, Sergio A Onate, Apolinaria García
Cancer is defined as an uncontrolled proliferation of malignant cells in a host and it is one of the main causes of death worldwide. Genetic and environmental factors play an important role in its development and the involvement of microbial communities has also recently been recognized. The close relationship that characterizes the colonization of human commensal communities involves health risks particularly when the homeostasis is disturbed. It has been hypothesized that this process may lead to cancer by modulating the inflammatory response of the host, by the production of carcinogenic metabolic products or by the production of toxins which disrupt the cell cycle...
October 21, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27880935/evolutionary-biologic-changes-of-gut-microbiota-in-an-adenoma-carcinoma-sequence-mouse-colorectal-cancer-model-induced-by-1-2-dimethylhydrazine
#3
Teng Sun, Shanglong Liu, Yanbing Zhou, Zengwu Yao, Dongfeng Zhang, Shougen Cao, Zhiliang Wei, Bin Tan, Yi Li, Zheng Lian, Song Wang
The molecular biological mechanisms underlying the evolutionary biologic changes leading to carcinogenesis remain unclear. The main objective of our study was to explore the evolution of the microbiota community and molecules related with CRC in the dynamic transition from normal colon epithelium to premalignant adenoma with the aid of an 'adenoma-carcinoma sequence' mouse CRC model induced by DMH. We generated a modified mouse CRC model induced by DMH for DNA sequences, and characterized the molecular networks...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27842559/dna-from-fecal-immunochemical-test-can-replace-stool-for-detection-of-colonic-lesions-using-a-microbiota-based-model
#4
Nielson T Baxter, Charles C Koumpouras, Mary A M Rogers, Mack T Ruffin, Patrick D Schloss
BACKGROUND: There is a significant demand for colorectal cancer (CRC) screening methods that are noninvasive, inexpensive, and capable of accurately detecting early stage tumors. It has been shown that models based on the gut microbiota can complement the fecal occult blood test and fecal immunochemical test (FIT). However, a barrier to microbiota-based screening is the need to collect and store a patient's stool sample. RESULTS: Using stool samples collected from 404 patients, we tested whether the residual buffer containing resuspended feces in FIT cartridges could be used in place of intact stool samples...
November 14, 2016: Microbiome
https://www.readbyqxmd.com/read/27821485/dietary-emulsifier-induced-low-grade-inflammation-promotes-colon-carcinogenesis
#5
Emilie Viennois, Didier Merlin, Andrew T Gewirtz, Benoit Chassaing
The increased risks conferred by inflammatory bowel disease (IBD) to the development of colorectal cancer (CRC) gave rise to the term "colitis-associated cancer" and the concept that inflammation promotes colon tumorigenesis. A condition more common than IBD is low-grade inflammation, which correlates with altered gut microbiota composition and metabolic syndrome, both present in many cases of CRC. Recent findings suggest that low-grade inflammation in the intestine is promoted by consumption of dietary emulsifiers, a ubiquitous component of processed foods which alter the composition of gut microbiota...
November 7, 2016: Cancer Research
https://www.readbyqxmd.com/read/27790385/role-of-the-microbiota-in-colorectal-cancer-updates-on-microbial-associations-and-therapeutic-implications
#6
REVIEW
Olivia I Coleman, Tiago Nunes
Genetic, environmental, and dietary factors have been found to influence the development and progression of colorectal cancer (CRC). More recently, accumulating evidence associates the intestinal microbiota with the initiation and progression of this disease. While studies have shown that individuals with CRC display alterations in gut bacterial composition, it remains somewhat unclear whether such differences drive cancer development or whether they are a response to tumorigenesis. In this review, the authors assess new evidence linking the community structure or specific bacterial factors of the intestinal microbiota to CRC development and progression, with insights into therapeutic implications...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27778343/periodontal-disease-tooth-loss-and-colorectal-cancer-risk-results-from-the-nurses-health-study
#7
Fatemeh Momen-Heravi, Ana Babic, Shelley S Tworoger, Libin Zhang, Kana Wu, Stephanie A Smith-Warner, Shuji Ogino, Andrew T Chan, Jeffrey Meyerhardt, Edward Giovannucci, Charles Fuchs, Eunyoung Cho, Dominique S Michaud, Meir J Stampfer, Yau-Hua Yu, David Kim, Xuehong Zhang
Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation, and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992...
October 25, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27722153/dietary-and-lifestyle-factors-associated-with-colorectal-cancer-risk-and-interactions-with-microbiota-fiber-red-or-processed-meat-and-alcoholic-drinks
#8
Juan Tuan, Ying-Xuan Chen
BACKGROUND: Diets and lifestyles have been strongly associated with colorectal cancer (CRC). In the past several decades, emerging evidence has suggested that the gut microbiota may have a role in the development of CRC. Its interaction with diets and lifestyles could affect the carcinogenesis of CRC. SUMMARY: This review presents the most recent epidemiologic and experimental evidence of three factors that may convincingly have a role in CRC, including fiber, red or processed meat, and alcohol, focusing on potential mechanisms and their interactions with the gut microbiota...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27697996/fecal-bacteria-act-as-novel-biomarkers-for-non-invasive-diagnosis-of-colorectal-cancer
#9
Jessie Qy Liang, Jonathan Chiu, Yingxuan Chen, Yanqin Huang, Akira Higashimori, Jing-Yuan Fang, Hassan Brim, Hassan Ashktorab, Siew Chien Ng, Simon Sm Ng, Shu Zheng, Francis Kl Chan, Joseph Jy Sung, Jun Yu
PURPOSE: Gut microbiota have been implicated in the development of colorectal cancer (CRC). We evaluated the utility of fecal bacterial marker candidates identified by our metagenome sequencing analysis for CRC diagnosis. EXPERIMENTAL DESIGN: 439 subjects (203 CRC and 236 healthy subjects) from two independent Asian cohorts were included. Probe-based duplex quantitative PCR (qPCR) assays were established for quantification of bacterial marker candidates. RESULTS: Candidates identified by metagenome sequencing, including Fusobacterium nucleatum (Fn), Bacteroides clarus (Bc), Roseburia intestinalis (Ri), Clostridium hathewayi (Ch), and one undefined species (labeled as m7), were examined in fecal samples of 203 CRC patients and 236 healthy controls by duplex-qPCR...
October 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27672054/shifts-in-the-fecal-microbiota-associated-with-adenomatous-polyps
#10
Vanessa L Hale, Jun Chen, Stephen Johnson, Sean C Harrington, Tracy C Yab, Thomas C Smyrk, Heidi Nelson, Lisa A Boardman, Brooke R Druliner, Theodore R Levin, Douglas K Rex, Dennis J Ahnen, Peter Lance, David A Ahlquist, Nicholas Chia
BACKGROUND: Adenomatous polyps are the most common precursor to colorectal cancer (CRC), the second leading cause of cancer death in the United States. We sought to learn more about early events of carcinogenesis by investigating shifts in the gut microbiota of patients with adenomas. METHODS: We analyzed 16S rRNA gene sequences from the fecal microbiota of patients with adenomas (n=233) and without (n=547). RESULTS: Multiple taxa were significantly more abundant in patients with adenomas, including Bilophila, Desulfovibrio, pro-inflammatory bacteria in the genus Mogibacterium, and multiple Bacteroidetes species...
September 26, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27649240/current-hypothesis-for-the-relationship-between-dietary-rice-bran-intake-the-intestinal-microbiota-and-colorectal-cancer-prevention
#11
Winnie K W So, Bernard M H Law, Patrick T W Law, Carmen W H Chan, Sek Ying Chair
Globally, colorectal cancer (CRC) is the third most common form of cancer. The development of effective chemopreventive strategies to reduce CRC incidence is therefore of paramount importance. Over the past decade, research has indicated the potential of rice bran, a byproduct of rice milling, in CRC chemoprevention. This was recently suggested to be partly attributable to modification in the composition of intestinal microbiota when rice bran was ingested. Indeed, previous studies have reported changes in the population size of certain bacterial species, or microbial dysbiosis, in the intestines of CRC patients and animal models...
2016: Nutrients
https://www.readbyqxmd.com/read/27590114/normalizing-microbiota-induced-retinoic-acid-deficiency-stimulates-protective-cd8-t-cell-mediated-immunity-in-colorectal-cancer
#12
Nupur Bhattacharya, Robert Yuan, Tyler R Prestwood, Hweixian Leong Penny, Michael A DiMaio, Nathan E Reticker-Flynn, Charles R Krois, Justin A Kenkel, Tho D Pham, Yaron Carmi, Lorna Tolentino, Okmi Choi, Reyna Hulett, Jinshan Wang, Daniel A Winer, Joseph L Napoli, Edgar G Engleman
Although all-trans-retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with colitis-associated CRC had a marked deficiency in colonic atRA due to alterations in atRA metabolism mediated by microbiota-induced intestinal inflammation. Human ulcerative colitis (UC), UC-associated CRC, and sporadic CRC specimens have similar alterations in atRA metabolic enzymes, consistent with reduced colonic atRA. Inhibition of atRA signaling promoted tumorigenesis, whereas atRA supplementation reduced tumor burden...
September 20, 2016: Immunity
https://www.readbyqxmd.com/read/27443884/american-ginseng-attenuates-colitis-associated-colon-carcinogenesis-in-mice-impact-on-gut-microbiota-and-metabolomics
#13
Chong-Zhi Wang, Chunhao Yu, Xiao-Dong Wen, Lina Chen, Chun-Feng Zhang, Tyler Calway, Yunping Qiu, Yunwei Wang, Zhiyu Zhang, Samantha Anderson, Yitao Wang, Wei Jia, Chun-Su Yuan
Inflammatory bowel disease is a risk factor for colorectal cancer initiation and development. In this study, the effects of American ginseng on chemically induced colitis and colon carcinogenesis were evaluated using an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. During the acute phase on day 15, the oral administration of ginseng (15 and 30 mg/kg/day) significantly suppressed AOM/DSS-induced colitis, as demonstrated by the disease activity index and colon tissue histology. During the chronic phase in week 13, AOM/DSS-induced tumor multiplicity was significantly suppressed by ginseng...
October 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27323816/could-gut-microbiota-serve-as-prognostic-biomarker-associated-with-colorectal-cancer-patients-survival-a-pilot-study-on-relevant-mechanism
#14
Zhiliang Wei, Shougen Cao, Shanglong Liu, Zengwu Yao, Teng Sun, Yi Li, Jiante Li, Dongfeng Zhang, Yanbing Zhou
Evidences have shown that dysbiosis could promote the progression of colorectal cancer (CRC). However, the association of dysbiosis and prognosis of CRC is barely investigated. Therefore, we used 16S rRNA gene sequencing approach to determine differences in microbiota among tumor tissues of different prognosis and found that Fusobacterium nucleatum and Bacteroides fragilis were more abundant in worse prognosis groups, while Faecalibacterium prausnitzii displayed higher abundance in survival group. To further explore the prognostic value of the found bacteria, Kaplan-Meier and Cox proportional regression analyses were used and the results exhibited that high abundance of F...
June 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27295340/ecophysiological-consequences-of-alcoholism-on-human-gut-microbiota-implications-for-ethanol-related-pathogenesis-of-colon-cancer
#15
Atsuki Tsuruya, Akika Kuwahara, Yuta Saito, Haruhiko Yamaguchi, Takahisa Tsubo, Shogo Suga, Makoto Inai, Yuichi Aoki, Seiji Takahashi, Eri Tsutsumi, Yoshihide Suwa, Hidetoshi Morita, Kenji Kinoshita, Yukari Totsuka, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Takeshi Mizukami, Akira Yokoyama, Takefumi Shimoyama, Toru Nakayama
Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effects of chronic ethanol consumption on the human gut microbiome are poorly understood, and the role of gut microbes in the proposed AcH-mediated pathogenesis of ER-CRC remains to be elaborated. Here we analyse and compare the gut microbiota structures of non-alcoholics and alcoholics...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27232063/parkinson-s-disease-and-colorectal-cancer-risk-a-nested-case-control-study
#16
Ben Boursi, Ronac Mamtani, Kevin Haynes, Yu-Xiao Yang
BACKGROUND: A pro-inflammatory gut microbiota was described in both Parkinson's disease and colorectal cancer (CRC) and recently α-synuclein was demonstrated in the enteric nervous system. We sought to evaluate the association between Parkinson's disease and CRC. METHODS: We conducted a nested case-control study using a large primary-care database. Cases were defined as all individuals with CRC. Up to 4 controls were matched with each case based on age, sex, practice-site and duration of follow-up...
August 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27221111/combination-therapy-of-lactobacillus-plantarum-supernatant-and-5-fluouracil-increases-chemosensitivity-in-colorectal-cancer-cells
#17
JaeJin An, Eun-Mi Ha
Colorectal cancer (CRC) is the third most common cancer in the world. Although 5-fluorouracil (5-FU) is the representative chemotherapy drug for colorectal cancer, it has therapeutic limits due to its chemoresistant characteristics. Colorectal cancer cells can develop into cancer stem cells (CSCs) with self-renewal potential, thereby causing malignant tumors. The human gastrointestinal tract contains a complex gut microbiota that is essential for the host's homeostasis. Recently, many studies have reported correlations between gut flora and the onset, progression, and treatment of CRC...
August 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27196124/effect-of-dietary-fibers-on-cecal-microbiota-and-intestinal-tumorigenesis-in-azoxymethane-treated-a-j-min-mice
#18
Birgitte Moen, Kristi Henjum, Ingrid Måge, Svein Halvor Knutsen, Ida Rud, Ragna Bogen Hetland, Jan Erik Paulsen
Foods naturally high in dietary fiber are generally considered to protect against development of colorectal cancer (CRC). However, the intrinsic effect of dietary fiber on intestinal carcinogenesis is unclear. We used azoxymethane (AOM) treated A/J Min/+ mice, which developed a significantly higher tumor load in the colon than in the small intestine, to compare the effects of dietary inulin (IN), cellulose (CE) or brewers spent grain (BSG) on intestinal tumorigenesis and cecal microbiota. Each fiber was tested at two dose levels, 5% and 15% (w/w) content of the AIN-93M diet...
2016: PloS One
https://www.readbyqxmd.com/read/27194068/mucosal-adherent-bacterial-dysbiosis-in-patients-with-colorectal-adenomas
#19
Yingying Lu, Jing Chen, Junyuan Zheng, Guoyong Hu, Jingjing Wang, Chunlan Huang, Lihong Lou, Xingpeng Wang, Yue Zeng
Recent reports have suggested that the gut microbiota is involved in the progression of colorectal cancer (CRC). The composition of gut microbiota in CRC precursors has not been adequately described. To characterize the structure of adherent microbiota in this disease, we conducted pyrosequencing-based analysis of 16S rRNA genes to determine the bacterial profile of normal colons (healthy controls) and colorectal adenomas (CRC precursors). Adenoma mucosal biopsy samples and adjacent normal colonic mucosa from 31 patients with adenomas and 20 healthy volunteers were profiled using the Illumina MiSeq platform...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27176600/target-identification-in-fusobacterium-nucleatum-by-subtractive-genomics-approach-and-enrichment-analysis-of-host-pathogen-protein-protein-interactions
#20
Amit Kumar, Pragna Lakshmi Thotakura, Basant Kumar Tiwary, Ramadas Krishna
BACKGROUND: Fusobacterium nucleatum, a well studied bacterium in periodontal diseases, appendicitis, gingivitis, osteomyelitis and pregnancy complications has recently gained attention due to its association with colorectal cancer (CRC) progression. Treatment with berberine was shown to reverse F. nucleatum-induced CRC progression in mice by balancing the growth of opportunistic pathogens in tumor microenvironment. Intestinal microbiota imbalance and the infections caused by F. nucleatum might be regulated by therapeutic intervention...
2016: BMC Microbiology
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