keyword
https://read.qxmd.com/read/38380806/increased-circulating-platelet-derived-extracellular-vesicles-in-severe-covid-19-disease
#21
JOURNAL ARTICLE
Tuukka Helin, Mari Palviainen, Marja Lemponen, Katariina Maaninka, Pia Siljander, Lotta Joutsi-Korhonen
Coagulation disturbances are major contributors to COVID-19 pathogenicity, but limited data exist on the involvement of extracellular vesicles (EVs) and residual cells (RCs). Fifty hospitalized COVID-19 patients stratified by their D-dimer levels into high (>1.5 mg/L, n  = 15) or low (≤1.5 mg/l, n  = 35) and 10 healthy controls were assessed for medium-sized EVs (mEVs; 200-1000 nm) and large EVs/RCs (1000-4000 nm) by high sensitivity flow cytometry...
December 2024: Platelets
https://read.qxmd.com/read/38377892/a-comparative-study-of-image-quality-and-diagnostic-confidence-in-diagnosis-and-follow-up-of-scaphoid-fractures-using-photon-counting-detector-ct-and-energy-integrating-detector-ct
#22
JOURNAL ARTICLE
Nina Kämmerling, Erik Tesselaar, Ronald Booij, Lotta Fornander, Anders Persson, Simon Farnebo
PURPOSE: Scaphoid fractures in patients and assessment of healing using PCD-CT have, as far as we know, not yet been studied. Therefore, the aim was to compare photon counting Detector CT (PCD-CT) with energy integrating detector CT (EID-CT) in terms of fracture visibility and evaluation of fracture healing. METHOD: Eight patients with scaphoid fracture were examined with EID-CT and PCD-CT within the first week post-trauma, and with additional scans at 4, 6 and 8 weeks...
February 17, 2024: European Journal of Radiology
https://read.qxmd.com/read/38373723/development-of-a-coagulation-disorders-unit
#23
JOURNAL ARTICLE
Timea Szanto, Tuukka Helin, Lotta Joutsi-Korhonen, Anna-Elina Lehtinen, Nancy El Beayni, Aino Lepäntalo, Riitta Lassila
Our Coagulation Disorders Unit in Helsinki, Finland, provides 24/7 services for local and national hospitals and colleagues upon requests regarding bleeding and thrombosis diagnostics and management, including follow-up. The unit has a tight connection between the clinic and laboratory, and its maintenance and sharing knowledge and observations have been priorities, already for over 20 years and will continue to be of major importance. The consultation service is provided by phone during daytime and on-call hours, and in written form sent electronically to the consulting stakeholders...
February 19, 2024: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/38373042/the-workforce-crisis-in-healthcare-moving-the-debate-to-bridge-evidence-and-policy
#24
EDITORIAL
Ellen Kuhlmann, Gabriela Lotta, Gilles Dussault, Michelle Falkenbach, Tiago Correia
This Special Issue aims to advance the healthcare workforce (HCWF) debate by directing its attention to the implementation of policy recommendations and identifying weaknesses. The selection of articles highlights a wide range of HCWF policies and interventions across various countries. The challenges faced often stem from policy failures and governance gaps at the macro-, meso- and micro-levels of health systems. Recommendations to mitigate the HCWF crisis include interconnected strategies, multi-/transsectoral policies, solidarity-based efforts, collaboration, skill-mix reforms, equity measures, global approaches, and crucially, strong political will...
February 19, 2024: International Journal of Health Planning and Management
https://read.qxmd.com/read/38369982/orchid-fruit-and-root-movement-analyzed-using-2d-photographs-and-a-bioinformatics-pipeline-for-processing-sequential-3d-scans
#25
JOURNAL ARTICLE
Dewi Pramanik, Lotta Vaskimo, K Joost Batenburg, Alexander Kostenko, Kevin Droppert, Erik Smets, Barbara Gravendeel
PREMISE: Most studies of the movement of orchid fruits and roots during plant development have focused on morphological observations; however, further genetic analysis is required to understand the molecular mechanisms underlying this phenomenon. A precise tool is required to observe these movements and harvest tissue at the correct position and time for transcriptomics research. METHODS: We utilized three-dimensional (3D) micro-computed tomography (CT) scans to capture the movement of fast-growing Erycina pusilla roots, and built an integrated bioinformatics pipeline to process 3D images into 3D time-lapse videos...
2024: Applications in Plant Sciences
https://read.qxmd.com/read/38366801/the-outcomes-of-team-based-learning-versus-small-group-interactive-learning-in-the-obstetrics-and-gynecology-course-for-undergraduate-students
#26
JOURNAL ARTICLE
Irene Sterpu, Lotta Herling, Jonas Nordquist, Anna Möller, Helena Kopp Kallner, Hedvig Engberg, Ganesh Acharya
INTRODUCTION: Team-based learning (TBL) is a well-established active teaching method which has been shown to have pedagogical advantages in some areas such as business education and preclinical disciplines in undergraduate medical education. Increasingly, it has been adapted to clinical disciplines. However, its superiority over conventional learning methods used in clinical years of medical school remains unclear. The aim of this study was to compare TBL with traditional seminars delivered in small group interactive learning (SIL) format in terms of knowledge acquisition and retention, satisfaction and engagement of undergraduate medical students during the 6-week obstetrics and gynecology clerkship...
February 17, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38366705/actualization-of-evidence-based-nursing-in-primary-specialized-and-social-care-settings-a-cross-sectional-survey
#27
JOURNAL ARTICLE
Hamari Lotta, Arja Holopainen, Nyman Johanna, Pukkila Heidi, Siltanen Hannele, Parisod Heidi
BACKGROUND: Basing practice on evidence is a widely acknowledged requirement for nursing, but shortcomings still exist. An increased understanding of the actualization of evidence-based nursing (EBN) across different nursing contexts is needed to develop better support for EBN and promote uniform high-quality nursing. AIMS: The aim of this study was to compare the actualization of EBN in different organizational contexts in Finland. METHODS: Data for this survey were collected in 2021...
February 17, 2024: Worldviews on Evidence-based Nursing
https://read.qxmd.com/read/38366324/is-epidural-analgesia-non-inferior-to-intrathecal-fentanyl-as-initiation-for-neuraxial-analgesia-in-early-non-spontaneous-labour
#28
JOURNAL ARTICLE
Lotta Salmi, Riina Jernman, Antti Väänänen
BACKGROUND AND AIM: Intrathecal fentanyl, using the combined spinal-epidural (CSE) technique, provides rapid analgesia during early labour. Because of the technique's more complex and invasive nature, as its replacement we assessed the use of epidural analgesia in primiparous parturients with induced labour. The study was registered at www. CLINICALTRIALS: gov (NCT04645823). The aim was to compare the efficacy, duration of analgesia and maternal satisfaction. The primary outcome was the difference in pain visual analogue scale (VAS) between the interventions at 20 min after the analgesia administration...
February 16, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38365833/advanced-patient-specific-microglia-cell-models-for-pre-clinical-studies-in-alzheimer-s-disease
#29
JOURNAL ARTICLE
Carla Cuní-López, Romal Stewart, Lotta E Oikari, Tam Hong Nguyen, Tara L Roberts, Yifan Sun, Christine C Guo, Michelle K Lupton, Anthony R White, Hazel Quek
BACKGROUND: Alzheimer's disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is a major contributor to neurodegeneration and hence, microglia, the brain's resident immune cells, are an attractive target for potentially more effective therapeutic strategies. However, there is no current in vitro model system that captures AD patient-specific microglial characteristics using physiologically relevant and experimentally flexible culture conditions...
February 15, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38364819/physical-behavior-profiles-among-older-adults-and-their-associations-with-physical-capacity-and-life-space-mobility
#30
JOURNAL ARTICLE
Lotta Palmberg, Antti Löppönen, Matti Hyvärinen, Erja Portegijs, Taina Rantanen, Timo Rantalainen, Laura Karavirta
We identified data-driven multidimensional physical activity (PA) profiles using several novel accelerometer-derived metrics. Participants aged 75, 80, and 85 (n = 441) wore triaxial accelerometers for 3-7 days. PA profiles were formed with k-means cluster analysis based on PA minutes, intensity, fragmentation, sit-to-stand transitions, and gait bouts for men and women. Associations with physical capacity and life-space mobility were examined using age-adjusted general linear models. Three profiles emerged: "Exercisers" and "actives" accumulated relatively high PA minutes, with actives engaging in lighter intensity PA...
February 16, 2024: Journal of Aging and Physical Activity
https://read.qxmd.com/read/38363803/the-core-elements-of-psychiatric-and-mental-health-nursing-time-honest-engagement-therapeutic-relations-professional-nursing-and-lifetime-perspective
#31
REVIEW
Anne-Marie Wangel, Karin Persson, Sara Duerlund, Johan Fhager, Emma Mårdhed, Lotta Sjögran, Karin Sjöström, Andreas Glantz, Karin Örmon, Charlotta Sunnqvist
Defining psychiatric and mental health nursing has been a challenge for decades, and it is still difficult to find a comprehensive definition. We have identified a possibility to clarify psychiatric and mental health nursing based on humanistic philosophy in a general psychiatric care context. The aim was therefore to identify and synthesize the theoretical frameworks from which psychiatric and mental health nursing models are developed. We systematically collected and evaluated articles based on Grounded Theory (GT) methodology regarding psychiatric or mental health nursing...
February 16, 2024: Issues in Mental Health Nursing
https://read.qxmd.com/read/38356763/the-crisis-is-over-long-live-the-crisis-mental-health-in-emerging-adulthood-during-the-course-of-the-covid-19-pandemic
#32
JOURNAL ARTICLE
Janine Wirkner, Eva-Lotta Brakemeier
INTRODUCTION: As a multidimensional stressor, the COVID-19 pandemic posed a significant threat to mental health, with studies showing younger age groups to be particularly vulnerable. Thus, this study aimed to monitor mental health, potential risk/protective factors, and pandemic-related variables among young university students during the pandemic. METHODS: Students of the University of Greifswald (M age = 23.0 years, 73.9% female) participated in five cross-sectional online surveys in December 2020 ( N  = 1,127), March 2021 ( N  = 760), June/July 2021 ( N  = 531), December 2021 ( N  = 1,226), and December 2022 ( N  = 814)...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38301283/the-profile-of-cholesterol-metabolism-does-not-interfere-with-the-cholesterol-lowering-efficacy-of-phytostanol-esters
#33
JOURNAL ARTICLE
Helena Gylling, Katariina Öörni, Lotta Nylund, Ingmar Wester, Piia Simonen
BACKGROUND & AIMS: Increasing evidence suggests that high cholesterol absorption efficiency enhances the risk of atherosclerotic cardiovascular diseases. It is not known whether inhibiting cholesterol absorption has different metabolic effects in high- vs. low cholesterol absorbers. We evaluated the effects of phytostanol esters on serum lipids and cholesterol metabolism in a post hoc study of three randomized, double-blind, controlled trials. The participants were classified into low (n = 20) and high (n = 21) cholesterol absorbers by median cholesterol absorption efficiency based on the plasma cholesterol absorption marker cholestanol at baseline...
January 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38296345/smoking-and-home-oxygen-therapy-a-review-and-consensus-statement-from-a-multidisciplinary-swedish-taskforce
#34
REVIEW
Zainab Ahmadi, Joar Björk, Hans Gilljam, Madhuri Gogineni, Torbjörn Gustafsson, Michael Runold, Thomas Ringbæk, Josefin Wahlberg, Lotta Wendel, Magnus Ekström
BACKGROUND: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and policies regarding this matter. This multidisciplinary Swedish taskforce aimed to review the potential benefits and risks of smoking in relation to HOT, including medical, practical, legal and ethical considerations...
January 31, 2024: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/38284169/discovery-and-characterization-of-a-bicyclic-peptide-bicycle-binder-to-thymic-stromal-lymphopoietin
#35
JOURNAL ARTICLE
Frank Narjes, Fredrik Edfeldt, Jens Petersen, Linda Öster, Corinne Hamblet, James Bird, Peter Bold, Rebecca Rae, Elisabeth Bäck, Stina Stomilovic, Pavol Zlatoidsky, Tor Svensson, Lotta Hidestål, Lavaniya Kunalingam, Igor Shamovsky, Leonardo De Maria, Euan Gordon, Richard J Lewis, Sophie Watcham, Katerine van Rietschoten, Gemma E Mudd, Helen Harrison, Liuhong Chen, Michael J Skynner
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived pro-inflammatory cytokine involved in the development of asthma and other atopic diseases. We used Bicycle Therapeutics' proprietary phage display platform to identify bicyclic peptides (Bicycles) with high affinity for TSLP, a target that is difficult to drug with conventional small molecules due to the extended protein-protein interactions it forms with both receptors. The hit series was shown to bind to TSLP in a hotspot, that is also used by IL-7Rα...
January 29, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38278648/peripheral-blood-mxa-levels-during-a-first-acute-wheezing-episode-and-the-link-to-childhood-asthma
#36
Heidi Makrinioti, Kiara Homil, Pekka Hurme, Riku Erkkola, Lotta Kinnunen, Zhaozhong Zhu, Matti Waris, Carlos A Camargo, Kohei Hasegawa, Tuomas Jartti
No abstract text is available yet for this article.
January 17, 2024: Archivos de Bronconeumología
https://read.qxmd.com/read/38276326/targeting-transcutaneous-spinal-cord-stimulation-using-a-supervised-machine-learning-approach-based-on-mechanomyography
#37
JOURNAL ARTICLE
Eira Lotta Spieker, Ardit Dvorani, Christina Salchow-Hömmen, Carolin Otto, Klemens Ruprecht, Nikolaus Wenger, Thomas Schauer
Transcutaneous spinal cord stimulation (tSCS) provides a promising therapy option for individuals with injured spinal cords and multiple sclerosis patients with spasticity and gait deficits. Before the therapy, the examiner determines a suitable electrode position and stimulation current for a controlled application. For that, amplitude characteristics of posterior root muscle (PRM) responses in the electromyography (EMG) of the legs to double pulses are examined. This laborious procedure holds potential for simplification due to time-consuming skin preparation, sensor placement, and required expert knowledge...
January 19, 2024: Sensors
https://read.qxmd.com/read/38268119/impact-of-congenital-heart-disease-on-personality-disorders-in-adulthood
#38
JOURNAL ARTICLE
Britta Stapel, Lotta Winter, Ivo Heitland, Friederike Löffler, Johann Bauersachs, Mechthild Westhoff-Bleck, Kai G Kahl
BACKGROUND AND AIMS: Adults with congenital heart disease (ACHD) constitute an ever-growing patient population characterized by high risks for cardiovascular- and mental disorders. Personality disorders (PDs) are associated with adverse physical and mental health. Studies assessing PD prevalence in ACHD are lacking. METHODS: PD point prevalence was assessed in 210 ACHD by Structured Clinical Interview for Axis-II Personality Disorders (SCID-II) and compared to meta-analytical data from the general population...
January 24, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38259058/characteristics-and-outcomes-of-non-operatively-managed-hip-fracture-patients-using-the-dutch-hip-fracture-audit-dhfa
#39
JOURNAL ARTICLE
Hanne-Eva van Bremen, Lotta J Seppala, Johannes H Hegeman, Nathalie van der Velde, Hanna C Willems
OBJECTIVE: This study aims to identify and compare characteristics of hip fracture patients treated non-operatively versus those treated operatively. DESIGN: Retrospective cohort study. SETTING: Hip fracture population-based study. PATIENT SELECTION CRITERIA: All adult patients with hip fractures (OTA/AO 31A and 31B) were included. Patients with pathological or periprosthetic hip fractures were excluded. OUTCOME MEASURES AND COMPARISONS: Patients were categorized according to the type of management (operative vs non-operative) and type of fracture (nondisplaced vs other)...
January 23, 2024: Journal of Orthopaedic Trauma
https://read.qxmd.com/read/38258026/immunomodulating-enzymes-from-streptococcus-pyogenes-in-pathogenesis-as-biotechnological-tools-and-as-biological-drugs
#40
REVIEW
Lotta Happonen, Mattias Collin
Streptococcus pyogenes , or Group A Streptococcus , is an exclusively human pathogen that causes a wide variety of diseases ranging from mild throat and skin infections to severe invasive disease. The pathogenesis of S. pyogenes infection has been extensively studied, but the pathophysiology, especially of the more severe infections, is still somewhat elusive. One key feature of S. pyogenes is the expression of secreted, surface-associated, and intracellular enzymes that directly or indirectly affect both the innate and adaptive host immune systems...
January 18, 2024: Microorganisms
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