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#1
Lotta Berg, Björn Olsen
No abstract text is available yet for this article.
2016: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/27898682/genetic-predisposition-to-an-impaired-metabolism-of-the-branched-chain-amino-acids-and-risk-of-type-2-diabetes-a-mendelian-randomisation-analysis
#2
Luca A Lotta, Robert A Scott, Stephen J Sharp, Stephen Burgess, Jian'an Luan, Therese Tillin, Amand F Schmidt, Fumiaki Imamura, Isobel D Stewart, John R B Perry, Luke Marney, Albert Koulman, Edward D Karoly, Nita G Forouhi, Rasmus J O Sjögren, Erik Näslund, Juleen R Zierath, Anna Krook, David B Savage, Julian L Griffin, Nishi Chaturvedi, Aroon D Hingorani, Kay-Tee Khaw, Inês Barroso, Mark I McCarthy, Stephen O'Rahilly, Nicholas J Wareham, Claudia Langenberg
BACKGROUND: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human genetic analyses to address this question. METHODS AND FINDINGS: Genome-wide studies of BCAA levels in 16,596 individuals revealed five genomic regions associated at genome-wide levels of significance (p < 5 × 10-8)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27894341/abdominal-obesity-gender-and-the-risk-of-rheumatoid-arthritis-a-nested-case-control-study
#3
Lotta Ljung, Solbritt Rantapää-Dahlqvist
BACKGROUND: The risk of development of rheumatoid arthritis (RA) could be affected by immune activation in obesity. Our objective was to evaluate the association between obesity in general, and abdominal obesity, and the risk for subsequent development of RA. METHODS: In two large population-based, prospective cohorts, 557 cases (mean age at RA symptom onset 58, SD 10 years, 68% women) who subsequently developed RA and 1671 matched controls were identified. From a health examination antedating symptom onset (median 5...
November 29, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27894205/outcomes-of-second-line-treatment-in-chronic-lymphocytic-leukemia-a-population-based-study-from-a-well-defined-geographical-region-between-2003-and-2013
#4
Anna Asklid, Maria Winqvist, Sandra Eketorp Sylvan, Agnes Mattsson, Einar Björgvinsson, Frans Søltoft, Johanna Repits, Joris Diels, Anders Österborg, Lotta Hansson
No abstract text is available yet for this article.
November 28, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27890395/the-recommodification-of-healthcare-a-case-study-of-user-charges-and-inequalities-in-access-to-healthcare-in-sweden-1980-2005
#5
Kristin Farrants, Clare Bambra, Lotta Nylen, Adetayo Kasim, Bo Burström, David Hunter
BACKGROUND: User charges in Swedish healthcare have increased during recent decades. This can be seen in terms of the recommodification of healthcare: making healthcare access more dependent on market position. This study investigates whether the increase in user charges had an impact on educational inequalities in access to healthcare in Sweden between 1980 and 2005. METHODS: Data from the Swedish Living Conditions Survey were used to calculate the odds ratios of access to healthcare for the low and higher educated in Sweden, and the results were stratified by health status (Good and Not good health) for each year 1980-2005...
November 14, 2016: Health Policy
https://www.readbyqxmd.com/read/27856675/metabolism-and-phospholipid-assembly-of-polyunsaturated-fatty-acids-in-human-bone-marrow-mesenchymal-stromal-cells
#6
Feven Tigistu-Sahle, Milla Lampinen, Lotta Kilpinen, Minna Holopainen, Petri Lehenkari, Saara Laitinen, Reijo Käkelä
High arachidonic acid (20:4n-6) and low n-3 polyunsaturated fatty acid (PUFA) levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune functions. Capacity of the hBMSCs to modify PUFA structures was found to be limited. Therefore different PUFA supplements given to the cells resulted in very different glycerophospholipid (GPL) species profiles and substrate availability for phospholipases, which have preferences for polar head group and acyl chains when liberating PUFA precursors for production of lipid mediators...
November 16, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27852979/expansion-induced-microrna-changes-in-bone-marrow-mesenchymal-stromal-cells-reveals-interplay-between-immune-regulation-and-cell-cycle
#7
Lotta Kilpinen, Amarjit Parmar, Dario Greco, Matti Korhonen, Petri Lehenkari, Päivi Saavalainen, Saara Laitinen
Mesenchymal stromal cells (MSC) are currently used in many cell based therapies. Prior to use in therapy, extensive expansion is required. We used microarray profiling to investigate expansion induced miRNA and mRNA expression changes of bone marrow MSCs (BM-MSCs) derived from old and young donors. The expression levels of 36 miRNAs were altered in cells derived from the old and respectively 39 miRNAs were altered in cells derived from young donors. Of these, only 12 were differentially expressed in both young and old donor BM-MSCs, and their predicted target mRNAs, were mainly linked to cell proliferation and senescence...
November 9, 2016: Aging
https://www.readbyqxmd.com/read/27827320/stories-of-victimization-self-positioning-and-construction-of-gender-in-narratives-of-abused-women
#8
Karin Jarnkvist, Lotta Brännström
The objective of this article is to analyze how women who have been victims of intimate partner violence (IPV) position themselves in relation to the image of the "ideal victim" and how gender is constructed in that positioning. There is a need for a gender analysis framework to understand how various forms of femininity are constructed and how narratives linked to this can either maintain a woman in an abusive relationship or encourage her to leave. Christie's theory of the "ideal victim" and Connell's gender theory are applied in this study, in which the narratives of 14 female IPV victims in Sweden are analyzed using a narrative method...
November 8, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27815572/phase-i-ii-study-of-lenalidomide-and-alemtuzumab-in-refractory-chronic-lymphocytic-leukemia-cll-effects-on-t-cells-and-immune-checkpoints
#9
Maria Winqvist, Fariba Mozaffari, Marzia Palma, Sandra Eketorp Sylvan, Lotta Hansson, Håkan Mellstedt, Anders Österborg, Jeanette Lundin
This phase I-II study explored safety, immunomodulatory and clinical effects of lenalidomide (weeks 1-16) and alemtuzumab (weeks 5-16) in 23 patients with refractory chronic lymphocytic leukemia. Most patients had Rai stage III/IV disease and were heavily pretreated (median 4 prior therapies), and 61% had del(17p)/del(11q). Eleven of 19 evaluable patients (58%) responded, with a median response duration of 12 months (1-29+); time to progression was short in non-responders. Lenalidomide had a narrow therapeutic dose range, 2...
November 4, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27810310/probiotic-with-or-without-fiber-controls-body-fat-mass-associated-with-serum-zonulin-in-overweight-and-obese-adults-randomized-controlled-trial
#10
Lotta K Stenman, Markus J Lehtinen, Nils Meland, Jeffrey E Christensen, Nicolas Yeung, Markku T Saarinen, Michael Courtney, Rémy Burcelin, Marja-Leena Lähdeaho, Jüri Linros, Dan Apter, Mika Scheinin, Hilde Kloster Smerud, Aila Rissanen, Sampo Lahtinen
BACKGROUND: The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalisssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-related parameters. METHODS: 225 healthy volunteers (healthy, BMI 28-34.9) were randomized into four groups (1:1:1:1), using a computer-generated sequence, for 6months of double-blind, parallel treatment: 1) Placebo, microcrystalline cellulose, 12g/d; 2) LU, 12g/d; 3) B420, 10(10)CFU/d in microcrystalline cellulose, 12g/d; 4) LU+B420, 12g+10(10)CFU/d...
October 26, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27802307/next-generation-sequencing-and-in-vitro-expression-study-of-adamts13-single-nucleotide-variants-in-deep-vein-thrombosis
#11
Maria Teresa Pagliari, Luca A Lotta, Hugoline G de Haan, Carla Valsecchi, Gloria Casoli, Silvia Pontiggia, Ida Martinelli, Serena M Passamonti, Frits R Rosendaal, Flora Peyvandi
BACKGROUND: Deep vein thrombosis (DVT) genetic predisposition is partially known. OBJECTIVES: This study aimed at assessing the functional impact of nine ADAMTS13 single nucleotide variants (SNVs) previously reported to be associated as a group with DVT in a burden test and the individual association of selected variants with DVT risk in two replication studies. METHODS: Wild-type and mutant recombinant ADAMTS13 were transiently expressed in HEK293 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27789754/unified-software-solution-for-efficient-spr-data-analysis-in-drug-research
#12
Göran Dahl, Stephan Steigele, Per Hillertz, Anna Tigerström, Anders Egnéus, Alexander Mehrle, Martin Ginkel, Fredrik Edfeldt, Geoff Holdgate, Nichole O'Connell, Bernd Kappler, Annette Brodte, Philip B Rawlins, Gareth Davies, Eva-Lotta Westberg, Rutger H A Folmer, Stephan Heyse
Surface plasmon resonance (SPR) is a powerful method for obtaining detailed molecular interaction parameters. Modern instrumentation with its increased throughput has enabled routine screening by SPR in hit-to-lead and lead optimization programs, and SPR has become a mainstream drug discovery technology. However, the processing and reporting of SPR data in drug discovery are typically performed manually, which is both time-consuming and tedious. Here, we present the workflow concept, design and experiences with a software module relying on a single, browser-based software platform for the processing, analysis, and reporting of SPR data...
October 27, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27788146/a-systematic-review-of-biomarkers-and-risk-of-incident-type-2-diabetes-an-overview-of-epidemiological-prediction-and-aetiological-research-literature
#13
Ali Abbasi, Anna-Stina Sahlqvist, Luca Lotta, Julia M Brosnan, Peter Vollenweider, Philippe Giabbanelli, Derek J Nunez, Dawn Waterworth, Robert A Scott, Claudia Langenberg, Nicholas J Wareham
BACKGROUND: Blood-based or urinary biomarkers may play a role in quantifying the future risk of type 2 diabetes (T2D) and in understanding possible aetiological pathways to disease. However, no systematic review has been conducted that has identified and provided an overview of available biomarkers for incident T2D. We aimed to systematically review the associations of biomarkers with risk of developing T2D and to highlight evidence gaps in the existing literature regarding the predictive and aetiological value of these biomarkers and to direct future research in this field...
2016: PloS One
https://www.readbyqxmd.com/read/27772773/predictors-of-health-related-quality-of-life-in-people-with-amyotrophic-lateral-sclerosis
#14
Petter Sandstedt, Sverker Johansson, Charlotte Ytterberg, Caroline Ingre, Lotta Widén Holmqvist, Marie Kierkegaard
BACKGROUND: Knowledge of factors influencing health-related quality of life (HRQL) in people with amyotrophic lateral sclerosis (ALS) is important because some factors might be amenable to intervention. OBJECTIVES: The aim was to describe and explore the effects of disease severity, fatigue, anxiety, depression, frequency of social and lifestyle activities, coping capacity and mechanical ventilator use on HRQL in people with ALS. METHODS: Sixty people with ALS were enrolled in this cross-sectional study...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27768720/risk-factors-for-fatal-hyperglycaemia-confirmed-by-forensic-postmortem-examination-a-nationwide-cohort-in-sweden
#15
Lotta Walz, Anna K Jönsson, Brita Zilg, Carl Johan Östgren, Henrik Druid
AIMS/HYPOTHESIS: The aim of this study was to identify risk factors associated with confirmed fatal hyperglycaemia, which could predispose potentially preventable deaths in individuals on glucose lowering drugs. METHODS: A retrospective register-based case-control study conducted on a nationwide cohort with individuals who died due to hyperglycaemia as determined by forensic postmortem examination, in Sweden August 2006 to December 2012. Vitreous glucose was used to diagnose hyperglycaemia postmortem...
2016: PloS One
https://www.readbyqxmd.com/read/27709827/-n%C3%A2-%C3%A2-%C3%A2-i-%C3%A2-%C3%A2-%C3%A2-n-halogen-bonded-dimeric-capsules-from-tetrakis-3-pyridyl-ethylene-cavitands
#16
Lotta Turunen, Ulrike Warzok, Rakesh Puttreddy, Ngong Kodiah Beyeh, Christoph A Schalley, Kari Rissanen
Two [N⋅⋅⋅I(+) ⋅⋅⋅N] halogen-bonded dimeric capsules using tetrakis(3-pyridyl)ethylene cavitands with different lower rim alkyl chains are synthesized and analyzed in solution and the gas phase. These first examples of symmetrical dimeric capsules making use of the iodonium ion (I(+) ) as the main connecting module are characterized by (1) H NMR spectroscopy, diffusion ordered NMR spectroscopy (DOSY), electrospray ionization mass spectrometry (ESI-MS), and ion mobility-mass spectrometry (TW-IMS) experiments...
October 6, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27701660/association-between-low-density-lipoprotein-cholesterol-lowering-genetic-variants-and-risk-of-type-2-diabetes-a-meta-analysis
#17
Luca A Lotta, Stephen J Sharp, Stephen Burgess, John R B Perry, Isobel D Stewart, Sara M Willems, Jian'an Luan, Eva Ardanaz, Larraitz Arriola, Beverley Balkau, Heiner Boeing, Panos Deloukas, Nita G Forouhi, Paul W Franks, Sara Grioni, Rudolf Kaaks, Timothy J Key, Carmen Navarro, Peter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, Jose-Ramón Quirós, Elio Riboli, Olov Rolandsson, Carlotta Sacerdote, Elena Salamanca-Fernandez, Nadia Slimani, Annemieke M W Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L van der A, Yvonne T van der Schouw, Mark I McCarthy, Inês Barroso, Stephen O'Rahilly, David B Savage, Naveed Sattar, Claudia Langenberg, Robert A Scott, Nicholas J Wareham
Importance: Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are associated with the risk of type 2 diabetes...
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27694661/developing-leadership-in-managers-to-facilitate-the-implementation-of-national-guideline-recommendations-a-process-evaluation-of-feasibility-and-usefulness
#18
Malin Tistad, Susanne Palmcrantz, Lars Wallin, Anna Ehrenberg, Christina B Olsson, Göran Tomson, Lotta Widén Holmqvist, Wendy Gifford, Ann Catrine Eldh
BACKGROUND: Previous research supports the claim that managers are vital players in the implementation of clinical practice guidelines (CPGs), yet little is known about interventions aiming to develop managers' leadership in facilitating implementation. In this pilot study, process evaluation was employed to study the feasibility and usefulness of a leadership intervention by exploring the intervention's potential to support managers in the implementation of national guideline recommendations for stroke care in outpatient rehabilitation...
April 11, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27681459/detecting-individual-extracellular-vesicles-using-a-multicolor-in-situ-proximity-ligation-assay-with-flow-cytometric-readout
#19
Liza Löf, Tonge Ebai, Louise Dubois, Lotta Wik, K Göran Ronquist, Olivia Nolander, Emma Lundin, Ola Söderberg, Ulf Landegren, Masood Kamali-Moghaddam
Flow cytometry is a powerful method for quantitative and qualitative analysis of individual cells. However, flow cytometric analysis of extracellular vesicles (EVs), and the proteins present on their surfaces has been hampered by the small size of the EVs - in particular for the smallest EVs, which can be as little as 40 nm in diameter, the limited number of antigens present, and their low refractive index. We addressed these limitations for detection and characterization of EV by flow cytometry through the use of multiplex and multicolor in situ proximity ligation assays (in situ PLA), allowing each detected EV to be easily recorded over background noise using a conventional flow cytometer...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27650127/cortical-plasticity-in-patients-with-median-nerve-lesions-studied-with-meg
#20
Lotta Fornander, Tom Brismar, Thomas Hansson, Heidi Wikström
We have previously shown age- and time-dependent effects on brain activity in the primary somatosensory cortex (SI), in a functional magnetic resonance imaging (fMRI) study of patients with median nerve injury. Whereas fMRI measures the hemodynamic changes in response to increased neural activity, magnetoencephalography (MEG) offers a more concise way of examining the evoked response, with superior temporal resolution. We therefore wanted to combine these imaging techniques to gain additional knowledge of the plasticity processes in response to median nerve injury...
September 2016: Somatosensory & Motor Research
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