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https://www.readbyqxmd.com/read/29472491/child-health-outcomes-after-presumptive-infection-treatment-in-pregnant-women-a-randomized-trial
#1
Lotta Hallamaa, Yin Bun Cheung, Kenneth Maleta, Mari Luntamo, Ulla Ashorn, Melissa Gladstone, Teija Kulmala, Charles Mangani, Per Ashorn
BACKGROUND AND OBJECTIVES: We showed earlier that presumptive infection treatment in pregnancy reduced the prevalence of neonatal stunting in a rural low-income setting. In this article, we assess how these gains were sustained and reflected in childhood growth, development, and mortality. METHODS: We enrolled 1320 pregnant Malawian women in a randomized trial and treated them for malaria and other infections with either 2 doses of sulfadoxine-pyrimethamine (SP) (control), monthly SP, or monthly sulfadoxine-pyrimethamine and 2 doses of azithromycin (AZI-SP)...
February 22, 2018: Pediatrics
https://www.readbyqxmd.com/read/29459902/whole-brain-parcellation-with-pathology-validation-on-ventriculomegaly-patients
#2
Aaron Carass, Muhan Shao, Xiang Li, Blake E Dewey, Ari M Blitz, Snehashis Roy, Dzung L Pham, Jerry L Prince, Lotta M Ellingsen
Numerous brain disorders are associated with ventriculomegaly; normal pressure hydrocephalus (NPH) is one example. NPH presents with dementia-like symptoms and is often misdiagnosed as Alzheimer's due to its chronic nature and nonspecific presenting symptoms. However, unlike other forms of dementia NPH can be treated surgically with an over 80% success rate on appropriately selected patients. Accurate assessment of the ventricles, in particular its sub-compartments, is required to diagnose the condition. Existing segmentation algorithms fail to accurately identify the ventricles in patients with such extreme pathology...
September 2017: Patch-Based Techniques in Medical Imaging: Third International Workshop, Patch-MI 2017, Held in Conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, Proceedings
https://www.readbyqxmd.com/read/29454858/expression-of-heat-shock-protein-70-and-cell-death-kinetics-after-different-thermal-impacts-on-cultured-retinal-pigment-epithelial-cells
#3
Katharina Kern, Carla-Lotta Mertineit, Ralf Brinkmann, Yoko Miura
Recent technologies are broadening the possibility to treat the retinal pigment epithelium (RPE) with different thermal impacts, from sublethal to lethal ranges. Thus temperature-dependent subcellular molecular responses need to be elucidated in more detail. In this study, RPE cell viability and expression of heat shock protein 70 (Hsp70) were investigated after thermal irradiation with different temperature increase using an in-vitro model. Primary porcine RPE cell cultures were irradiated with different laser power of a thulium laser (λ = 1940 nm, beam-diameter 30 mm) for 10 s, such that the maximal temperatures at the center of the culture dish (Tmax ) reach 40, 44, 47, 51 or 59 °C after 10s' irradiation...
February 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29449696/snail-regulates-bmp-and-tgf%C3%AE-pathways-to-control-the-differentiation-status-of-glioma-initiating-cells
#4
Laia Caja, Kalliopi Tzavlaki, Mahsa S Dadras, E-Jean Tan, Gad Hatem, Naga P Maturi, Anita Morén, Lotta Wik, Yukihide Watanabe, Katia Savary, Masood Kamali-Moghaddan, Lene Uhrbom, Carl-Henrik Heldin, Aristidis Moustakas
Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGFβ1 signaling activity...
February 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29444931/complete-remission-with-reduction-of-high-risk-clones-following-haploidentical-nk-cell-therapy-against-mds-and-aml
#5
Andreas T Björklund, Mattias Carlsten, Ebba Sohlberg, Lisa L Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley, Jeffrey S Miller, Monika Klimkowska, Marie Schaffer, Emma Watz, Kristina I Wikstrom, Pontus Blomberg, Bjorn E Wahlin, Marzia Palma, Lotta Hansson, Per Ljungman, Eva Hellström-Lindberg, Hans-Gustaf Ljunggren, Karl-Johan Malmberg
PURPOSE: To evaluate the safety, efficacy and immunobiological correlates of allogeneic NK cell-based therapy in primary chemotherapy-refractory or relapsed high-risk myelodysplastic syndrome (MDS), secondary AML (MDS/AML), and de novo AML patients. EXPERIMENTAL DESIGN: Sixteen patients received fludarabine/cyclophosphamide conditioning combined with total lymphoid irradiation followed by adoptive immunotherapy with IL-2-activated haploidentical NK cells. RESULTS: NK cell infusions were well tolerated with only transient adverse events observed in the 16 patients...
February 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29444651/perceived-health-and-work-environment-related-problems-and-associated-subjective-production-loss-in-an-academic-population
#6
Malin Lohela-Karlsson, Lotta Nybergh, Irene Jensen
BACKGROUND: The aim was to investigate the prevalence of health problems and work environment problems and how these are associated with subjective production loss among women and men at an academic workplace. An additional aim was to investigate whether there were differences between women and men according to age group, years at current workplace, academic rank or managerial position. METHODS: A questionnaire was sent in 2011 to all employees at a Swedish university (n = 5144)...
February 14, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29435855/the-clinical-impact-of-molecular-breast-imaging-in-women-with-proven-invasive-breast-cancer-scheduled-for-breast-conserving-surgery
#7
Angela Collarino, Renato A Valdés Olmos, Lotta G A J van Berkel, Peter A Neijenhuis, Lidy M H Wijers, Frederik Smit, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
PURPOSE: To investigate the clinical utility of molecular breast imaging (MBI) in patients with proven invasive breast cancer scheduled for breast-conserving surgery (BCS). METHODS: Following approval by the institutional review board and written informed consent, records of patients with newly diagnosed breast cancer scheduled for BCS who had undergone MBI for local staging in the period from March 2012 till December 2014 were retrospectively reviewed. RESULTS: A total of 287 women (aged 30-88 years) were evaluated...
February 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29433794/clinically-variable-nemaline-myopathy-in-a-three-generation-family-caused-by-mutation-of-the-skeletal-muscle-alpha-actin-gene
#8
Vilma-Lotta Lehtokari, Maria Gardberg, Katarina Pelin, Carina Wallgren-Pettersson
We present here a Finnish nemaline myopathy family with a dominant mutation in the skeletal muscle α-actin gene, p.(Glu85Lys), segregating in three generations. The index patient, a 5-year-old boy, had the typical form of nemaline myopathy with congenital muscle weakness and motor milestones delayed but reached, while his mother never had sought medical attention for her very mild muscle weakness, and his maternal grandmother had been misdiagnosed as having myotonic dystrophy. This illustrates the clinical variability in nemaline myopathy...
December 25, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29432497/autologous-t-cells-expressing-the-oncogenic-transcription-factor-klf6-sv1-prevent-apoptosis-of-chronic-lymphocytic-leukemia-cells
#9
Parviz Kokhaei, Mohammad Hojjat-Farsangi, Fariba Mozaffari, Ali Moshfegh, Fatemeh Pak, Ali Rashidy-Pour, Marzia Palma, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Crosstalk between leukemic cells and the tumor microenvironment is of importance in chronic lymphocytic leukemia (CLL). T cells seem to sustain the survival of CLL cells by various mechanisms. The Krüppel-like family of transcription factors (KLFs) are identified as regulators of proliferation and cell death. In the present study, we analyzed the expression of the wild type (WT) gene KLF6 and the oncogenic splice variant 1 (KLF6-SV1) at the mRNA level in subsets of T cells from CLL patients (n = 29), multiple myeloma patients (n = 6) and normal donors (n = 10)...
2018: PloS One
https://www.readbyqxmd.com/read/29420722/craniofacial-morphology-and-growth-in-young-patients-with-congenital-or-childhood-onset-myotonic-dystrophy
#10
Clara Fontinha, Monica Engvall, Lotta Sjögreen, Stavros Kiliaridis
Background/objectives: This study investigated the craniofacial morphology of young individuals with congenital or childhood onset myotonic dystrophy type 1 (DM1) compared to healthy subjects. The study also followed growth changes in their facial morphology over a 5-year period. Materials/methods: Lateral cephalograms of the 26 subjects (young patients with DM1 from west and south Sweden) were taken at baseline and after a 5-year period. These radiographs were compared with normal standards based on healthy individuals from the Michigan Growth Study, according to their age and sex, using paired t-tests (P < 0...
February 6, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29415060/precision-of-mri-based-body-composition-measurements-of-postmenopausal-women
#11
Janne West, Thobias Romu, Sofia Thorell, Hanna Lindblom, Emilia Berin, Anna-Clara Spetz Holm, Lotta Lindh Åstrand, Anette Karlsson, Magnus Borga, Mats Hammar, Olof Dahlqvist Leinhard
OBJECTIVES: To determine precision of magnetic resonance imaging (MRI) based fat and muscle quantification in a group of postmenopausal women. Furthermore, to extend the method to individual muscles relevant to upper-body exercise. MATERIALS AND METHODS: This was a sub-study to a randomized control trial investigating effects of resistance training to decrease hot flushes in postmenopausal women. Thirty-six women were included, mean age 56 ± 6 years. Each subject was scanned twice with a 3...
2018: PloS One
https://www.readbyqxmd.com/read/29413716/proteomic-profiling-of-epileptogenesis-in-a-rat-model-focus-on-cell-stress-extracellular-matrix-and-angiogenesis
#12
Michael Keck, Roelof Maarten van Dijk, Cornelia A Deeg, Katharina Kistler, Andreas Walker, Eva-Lotta von Rüden, Vera Russmann, Stefanie M Hauck, Heidrun Potschka
Information about epileptogenesis-associated changes in protein expression patterns is of particular interest for future selection of target and biomarker candidates. Bioinformatic analysis of proteomic data sets can increase our knowledge about molecular alterations characterizing the different phases of epilepsy development following an initial epileptogenic insult. Here, we report findings from a focused analysis of proteomic data obtained for the hippocampus and parahippocampal cortex samples collected during the early post-insult phase, latency phase, and chronic phase of a rat model of epileptogenesis...
April 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29402652/fall-risk-increasing-drugs-a-systematic-review-and-meta-analysis-ii-psychotropics
#13
Lotta J Seppala, Anne M A T Wermelink, Max de Vries, Kimberley J Ploegmakers, Esther M M van de Glind, Joost G Daams, Nathalie van der Velde
BACKGROUND AND OBJECTIVE: Falls are a major public health problem in older adults. Earlier studies showed that psychotropic medication use increases the risk of falls. The aim of this study is to update the current knowledge by providing a comprehensive systematic review and meta-analysis on psychotropic medication use and falls in older adults. METHODS AND DESIGN: This study is a systematic review and meta-analysis. A search was conducted in Medline, PsycINFO, and Embase...
February 2, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29402646/fall-risk-increasing-drugs-a-systematic-review-and-meta-analysis-iii-others
#14
Lotta J Seppala, Esther M M van de Glind, Joost G Daams, Kimberley J Ploegmakers, Max de Vries, Anne M A T Wermelink, Nathalie van der Velde
BACKGROUND AND OBJECTIVE: The use of psychotropic medication and cardiovascular medication has been associated with an increased risk of falling. However, other frequently prescribed medication classes are still under debate as potential risk factors for falls in the older population. The aim of this systematic review and meta-analysis is to evaluate the associations between fall risk and nonpsychotropic and noncardiovascular medications. METHODS AND DESIGN: A systematic review and meta-analysis...
February 2, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29396189/fall-risk-increasing-drugs-a-systematic-review-and-meta-analysis-i-cardiovascular-drugs
#15
Max de Vries, Lotta J Seppala, Joost G Daams, Esther M M van de Glind, Tahir Masud, Nathalie van der Velde
BACKGROUND AND OBJECTIVE: Use of certain medications is recognized as a major and modifiable risk factor for falls. Although the literature on psychotropic drugs is compelling, the literature on cardiovascular drugs as potential fall-risk-increasing drugs is conflicting. The aim of this systematic review and meta-analysis is to provide a comprehensive overview of the associations between cardiovascular medications and fall risk in older adults. METHODS: Design: A systematic review and meta-analysis...
January 30, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29373441/the-impact-of-thyroid-autoimmunity-on-thyroid-function-in-12-year-old-children-with-celiac-disease
#16
Fredrik Norström, Maria van der Pals, Anna Myléus, Solveig Hammarroth, Lotta Högberg, Anders Isaksson, Anneli Ivarsson, Annelie Carlsson
OBJECTIVES: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. However, data are lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. METHODS: A case-referent study was conducted as part of a CD screening of 12-year-olds...
January 25, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29371334/poor-compliance-and-increased-mortality-depression-and-healthcare-costs-in-patients-with-congenital-adrenal-hyperplasia
#17
Sara Jenkins-Jones, Lotta Parviainen, John Porter, Mike Withe, Martin Whitaker, Sarah E Holden, Christopher Llewellyn Morgan, Craig Currie, Richard J Ross
Objectives To evaluate risks of depression and all-cause mortality, healthcare utilisation costs, and treatment adherence in congenital adrenal hyperplasia (CAH) in the UK. Design and Methods A retrospective, matched-cohort study using UK primary-care data from the Clinical Practice Research Datalink linked to hospital and death-certification data. Patients diagnosed with CAH and having ≥1 corticosteroid prescription were matched 1:10 to reference subjects. Risk of death and lifetime prevalence of depression were compared using Cox regression models...
January 25, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29367682/activation-of-activin-receptor-like-kinases-curbs-mucosal-inflammation-and-proliferation-in-chronic-rhinosinusitis-with-nasal-polyps
#18
Lotta Tengroth, Julia Arebro, Olivia Larsson, Claus Bachert, Susanna Kumlien Georén, Lars-Olaf Cardell
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a widespread disease causing obstruction of the nasal cavity. Its cause remains unclear. The transforming growth-factor beta (TGF-β) superfamily and their receptors, termed Activin receptor-like kinases (ALKs), have recently been suggested to play a role in local airway inflammation, but have so far not been evaluated in human nasal epithelial cells (HNECs) from CRSwNP patients. We demonstrated that ALK1-7 were expressed in the nasal polyp epithelium, and the expression of ALK1-6 was markedly elevated in polyps compared to nasal mucosa from healthy controls...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29357814/-you-just-need-to-leave-the-room-when-you-breastfeed-breastfeeding-experiences-among-obese-women-in-sweden-a-qualitative-study
#19
Ing-Marie Claesson, Lotta Larsson, Linda Steen, Siw Alehagen
BACKGROUND: The benefits of breastfeeding for the infant as well for the mother are well-known. It is recognized that obese (Body Mass Index ≥30 kg/m2) women may have less antenatal intention to breastfeed, and shortened duration of breastfeeding compared with normal-weight women. This may result in adverse short- and long-term health for both mother and child, such as a shortened lactational amenorrhoea and decreased protection against breast cancer for the women, and an increased risk for infectious diseases and overweight/obesity among the children...
January 22, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29352489/prospective-questionnaire-study-showed-that-higher-self-efficacy-predicted-longer-exclusive-breastfeeding-by-the-mothers-of-late-preterm-infants
#20
Emma Gerhardsson, Ingegerd Hildingsson, Elisabet Mattsson, Eva-Lotta Funkquist
AIM: An important variable that influences breastfeeding outcomes is how confident a woman feels about her ability to breastfeed successfully at an early stage. We investigated breastfeeding self-efficacy in the mothers of late preterm infants. METHODS: This was a prospective, comparative study that focused on mothers who had delivered babies at 34+0 to 36+6 weeks and were recruited in 2012-2015 from a neonatal intensive care unit and a postnatal ward at a Swedish university hospital...
January 20, 2018: Acta Paediatrica
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