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https://www.readbyqxmd.com/read/29221117/inhibition-of-chemerin-cmklr1-axis-in-neuroblastoma-cells-reduces-clonogenicity-and-cell-viability-in-vitro-and-impairs-tumor-growth-in-vivo
#1
Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Lotta Helena Maria Elfman, Jan-Olof Winberg, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson
Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer. In neuroblastoma, a childhood tumor of the peripheral nervous system we identified correlations between high CMKLR1 and GPR1 expression and reduced overall survival probability. CMKLR1, GPR1, and chemerin RNA and protein were detected in neuroblastoma cell lines and neuroblastoma primary tumor tissue...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220091/john-walker-smith-the-father-of-european-paediatric-gastroenterology
#2
Lars Stenhammar, Lotta Högberg, Lars Browaldh, Mats Eriksson, Bo Tjellström
No abstract text is available yet for this article.
December 8, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29214483/psychotherapyplus-augmentation-of-cognitive-behavioral-therapy-cbt-with-prefrontal-transcranial-direct-current-stimulation-tdcs-in-major-depressive-disorder-study-design-and-methodology-of-a-multicenter-double-blind-randomized-placebo-controlled-trial
#3
Malek Bajbouj, Sabine Aust, Jan Spies, Ana-Lucia Herrera-Melendez, Sarah V Mayer, Maike Peters, Christian Plewnia, Andreas J Fallgatter, Lukas Frase, Claus Normann, Nora Behler, Linda Wulf, Eva-Lotta Brakemeier, Frank Padberg
Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. About 20-30% of patients do not respond to the standard psychopharmacological and/or psychotherapeutic interventions. Mounting evidence from neuroimaging studies in MDD patients reveal altered activation patterns in lateral prefrontal brain areas. Successful cognitive behavioral therapy (CBT) is associated with a recovery of these neural alterations. Moreover, it has been demonstrated that transcranial direct current stimulation (tDCS) is capable of influencing prefrontal cortex activity and cognitive functions such as working memory and emotion regulation...
December 6, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29205943/self-complementary-dimers-of-oxalamide-functionalized-resorcinarene-tetrabenzoxazines
#4
Kari Rissanen, Mario Cetina, Zoran Dzolic, Ngong Kodiah Beyeh, Lotta Turunen
Self-complementarity is a useful concept in supramolecular chemistry, molecular biology and polymeric systems. Two resorcinarene tetrabenzoxazines decorated with four oxalamide groups are synthesized and characterized. The oxalamide groups possessed self-complementary hydrogen bonding sites between the carbonyls and amide groups. The self-complementary nature of the oxalamide groups resulted in self-included dimeric assemblies. The hydrogen bonding interactions within the tetrabenzoxazines give rise to the formation of dimers, which are confirmed by single crystal X-ray diffractions analysis and supported by NMR spectroscopy and mass spectrometry...
December 5, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29173513/enabling-at-homeness-for-residents-living-in-a-nursing-home-reflected-experience-of-nursing-home-staff
#5
Lotta Saarnio, Anne-Marie Boström, Ragnhild Hedman, Petter Gustavsson, Joakim Öhlén
Older people are often living the last period of their lives in institutions such as nursing homes. Knowledge of this period, specifically related to at-homeness which can be described as wellbeing in spite of illness and has been regarded as one of the goals in palliative care, has been very little researched in the context of nursing homes and the experience of nursing home staff. The aim of this study was to explore the experiences of nursing home staff of how to enable at-homeness for residents. Qualitative interpretive description methodology guided the design...
December 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/29160079/a-comprehensive-mass-spectrometric-survey-of-streptococcus-pyogenes-subcellular-proteomes
#6
Laura Wilk, Lotta Happonen, Johan Malmström, Heiko Herwald
Streptococcus pyogenes is a major global health burden causing a wide variety of diseases. As a vaccine against this bacterium is still lacking, vaccine candidates or antimicrobial therapies are urgently needed. Here, we use an invasive and clinical relevant streptococcal M1 serotype in order to characterise the bacterial proteome in-depth. An elaborate fractionation technique is employed to separate the different cell fractions followed by shotgun mass spectrometry analysis, allowing us to confirm the expression of nearly two thirds (1022) of the 1690 open reading frames predicted for the streptococcal M1 reference proteome...
November 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29120680/a-clinical-evaluation-of-a-transparent-absorbent-adhesive-wound-dressing
#7
Lotta von Cramon, Marta Markowicz, Jan Nebendahl, Verena-Constanze Buchinger-Kähler, Ernst Magnus Noah, Mustafa Narwan, Anika Behrendt, Norbert Pallua, Amrei Steinhoff
The performance of a transparent absorbent adhesive wound dressing (TAAWD) was observed over 7 days in five plastic surgery clinics across Germany. The study included 47 diverse postoperative linear wounds and donor sites with dry or minimal exudate levels. Data on ease of application and removal, adhesive strength, skin compatibility, conformability to the body, visual wound inspection and parameters of wound assessment were collected and analysed. At the end of the observation period, 100% of wounds were recorded as healing with no reported complications...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29119482/patterns-of-comorbidity-and-disease-characteristics-among-patients-with-ankylosing-spondylitis-a-cross-sectional-study
#8
Lotta Ljung, Björn Sundström, Johan Smeds, Maria Ketonen, Helena Forsblad-d'Elia
The knowledge of the development of comorbidities in patients with ankylosing spondylitis (AS) is limited. The aim of this study was to analyse associations between AS disease characteristics and comorbidity and to evaluate patterns of comorbidities in patients with AS. Patients with AS, fulfilling the modified New York Criteria, were identified (n = 346, mean age 56 ± 15 years, 75% men, 99% HLA B27 positive). Through a review of the patient records, data on disease activity parameters, laboratory results, disease manifestations, and diagnoses of any clinically significant comorbidity was obtained...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29104822/early-skin-to-skin-contact-between-healthy-late-preterm-infants-and-their-parents-an-observational-cohort-study
#9
Kerstin H Nyqvist, Andreas Rosenblad, Helena Volgsten, Eva-Lotta Funkquist, Elisabet Mattsson
Background: Skin-to-skin contact (SSC) is an important factor to consider in the care of late preterm infants (born between 34 0/7 and 36 6/7 completed weeks of gestation). The literature suggests that SSC between preterm infants and their mothers facilitates breastfeeding. However, more studies are needed to explore potential dose-response effects between SSC and breastfeeding as well as studies that explicitly investigate SSC by fathers among late preterm infants. The aim was to investigate the duration of healthy late preterm infants' SSC with the mother and father, respectively, during the first 48 h after birth and the associations with breastfeeding (exclusive/partial at discharged), clinical and demographic variables...
2017: PeerJ
https://www.readbyqxmd.com/read/29104140/low-dose-%C3%AE-secretase-inhibition-increases-secretion-of-a%C3%AE-peptides-and-intracellular-oligomeric-a%C3%AE
#10
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg
γ-Secretase inhibitors have been considered promising drug candidates against Alzheimer's disease (AD) due to their ability to reduce amyloid-β (Aβ) production. However, clinical trials have been halted due to lack of clinical efficacy and/or side effects. Recent in vitro studies suggest that low doses of γ-secretase inhibitors may instead increase Aβ production. Using a stem cell-derived human model of cortical neurons and low doses of the γ-secretase inhibitor DAPT, the effects on a variety of Aβ peptides were studied using mass spectrometry...
November 8, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29041969/glial-cells-are-functionally-impaired-in-juvenile-neuronal-ceroid-lipofuscinosis-and-detrimental-to-neurons
#11
Lotta Parviainen, Sybille Dihanich, Greg W Anderson, Andrew M Wong, Helen R Brooks, Rosella Abeti, Payam Rezaie, Giovanna Lalli, Simon Pope, Simon J Heales, Hannah M Mitchison, Brenda P Williams, Jonathan D Cooper
The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically occurs early in disease progression and predicts where neuron loss subsequently occurs. We have found that in the most common juvenile form of NCL (CLN3 disease or JNCL) this glial response is less pronounced in both mouse models and human autopsy material, with the morphological transformation of both astrocytes and microglia severely attenuated or delayed...
October 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29038446/external-quality-assurance-for-laboratory-identification-and-capsular-typing-of-streptococcus-pneumoniae
#12
Hans-Christian Slotved, Carmen L Sheppard, Tine Dalby, Arie van der Ende, Norman K Fry, Eva Morfeldt, Outi Nyholm, Assaf Rokney, Merav Ron, Lotta Siira, Kevin J Scott, Andrew Smith, Louise Thom, Maija Toropainen, Didrik F Vestrheim
An external quality assessment (EQA) scheme for pneumococcal serotype identification has been performed over a period of 11 years, by a network of European pneumococcal reference laboratories. We report the results from the EQA, and present an assessment of the acceptability and utility of the EQA scheme. Reports from 22 EQA panels distributed in 2005-2016 were analysed. Each EQA panel consisted of seven isolates. A questionnaire including seven questions related to the acceptability and utility of the EQA scheme was distributed to all participating laboratories...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28970218/mortality-following-new-onset-rheumatoid-arthritis-has-modern-rheumatology-had-an-impact
#13
Marie Holmqvist, Lotta Ljung, Johan Askling
OBJECTIVE: To investigate if, and when, patients diagnosed with rheumatoid arthritis (RA) in recent years are at increased risk of death. METHODS: Using an extensive register linkage, we designed a population-based nationwide cohort study in Sweden. Patients with new-onset RA from the Swedish Rheumatology Quality Register, and individually matched comparators from the general population were followed with respect to death, as captured by the total population register...
September 26, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28968301/diminished-coagulation-capacity-assessed-by-calibrated-automated-thrombography-during-acute-puumala-hantavirus-infection
#14
Sirpa M Koskela, Lotta Joutsi-Korhonen, Satu M Mäkelä, Heini Huhtala, Antti I Vaheri, Ilkka Pörsti, Jukka T Mustonen, Outi K Laine
: Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV-HFRS). We evaluated the coagulation capacity of plasma during acute PUUV-HFRS by measuring thrombin generation using calibrated automated thrombography (CAT). The study cohort comprised 27 prospectively collected, consecutive, hospital-treated patients with acute PUUV infection. Blood samples were drawn in the acute phase and at the control visit approximately 5 weeks later. To evaluate thrombin generation, the lag time of initiation, endogenous thrombin potential (ETP), and peak and time to peak thrombin concentration were assessed by CAT in platelet poor plasma without corn trypsin inhibitor...
September 28, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28956140/cognitive-behavioral-analysis-system-of-psychotherapy-as-group-psychotherapy-for-chronically-depressed-inpatients-a-naturalistic-multicenter-feasibility-trial
#15
Lena Sabaß, Frank Padberg, Claus Normann, Vera Engel, Carsten Konrad, Kristina Helmle, Andrea Jobst, Andrew Worlitz, Eva-Lotta Brakemeier
The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a relatively new approach in the treatment of chronic depression (CD). Adapted as group psychotherapy for inpatients, CBASP is attracting increasing attention. In this naturalistic multicenter trial, we investigated its feasibility after 10 sessions of CBASP group therapy over a treatment time of at least 5 to a maximum of 10 weeks. Treatment outcome was additionally assessed. Across four centers, 116 inpatients with CD (DSM-IV-TR) attended CBASP group psychotherapy...
September 27, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28939745/a-novel-breast-cancer-index-for-prediction-of-distant-recurrence-in-hr-early-stage-breast-cancer-with-1-to-3-positive-nodes
#16
Yi Zhang, Brock E Schroeder, Piiha-Lotta Jerevall, Amy Ly, Hannah Nolan, Catherine A Schnabel, Dennis Sgroi
Study objective was to characterize the prognostic performance of a novel Breast Cancer Index model (BCIN+), an integration of BCI gene expression, tumor size, and grade, specifically developed for assessment of distant recurrence (DR) risk in HR+ breast cancer patients with 1-3 positive lymph nodes (pN1). <br><br> Experimental Design: Analysis was conducted in a well-annotated retrospective series of pN1 patients (N=402) treated with adjuvant endocrine therapy with or without chemotherapy using a pre-specified model...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28939621/cholesterol-embolism-it-s-always-a-good-idea-to-look-into-the-eye
#17
Alfredo Iardino, Orlando Garner, Ana Ramirez, Franco Lotta
No abstract text is available yet for this article.
September 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28927707/pcsk9-inhibition-and-type-2-diabetes
#18
Luca A Lotta, Simon J Griffin
No abstract text is available yet for this article.
September 14, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28912815/feasibility-of-metatranscriptome-analysis-from-infant-gut-microbiota-adaptation-to-solid-foods-results-in-increased-activity-of-firmicutes-at-six-months
#19
Floor Hugenholtz, Jarmo Ritari, Lotta Nylund, Mark Davids, Reetta Satokari, Willem M de Vos
Newborns are rapidly colonized by microbes and their intestinal tracts contain highly dynamic and rapidly developing microbial communities in the first months of life. In this study, we describe the feasibility of isolating mRNA from rapidly processed faecal samples and applying deep RNA-Seq analysis to provide insight into the active contributors of the microbial community in early life. Specific attention is given to the impact of removing rRNA from the mRNA on the phylogenetic and transcriptional profiling and its analysis depth...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28892142/loneliness-and-friendships-among-eight-year-old-children-time-trends-over-a-24-year-period
#20
Lotta Lempinen, Niina Junttila, Andre Sourander
BACKGROUND: Loneliness in childhood has a wide range of negative consequences for well-being and mental health later in life. This study reports time-trends in children's loneliness and the association between children's loneliness and psychiatric symptoms over a 24-year period. METHODS: Information on 3,749 eight-year-old Finnish-speaking children born in 1981, 1991, 1997, and 2004 was gathered at four time points from the area covered by Turku University Hospital in southwest Finland...
September 11, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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