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https://www.readbyqxmd.com/read/28087490/longitudinal-multiple-sclerosis-lesion-segmentation-resource-challenge
#1
Aaron Carass, Snehashis Roy, Amod Jog, Jennifer L Cuzzocreo, Elizabeth Magrath, Adrian Gherman, Julia Button, James Nguyen, Ferran Prados, Carole H Sudre, Manuel Jorge Cardoso, Niamh Cawley, Olga Ciccarelli, Claudia A M Wheeler-Kingshott, Sébastien Ourselin, Laurence Catanese, Hrishikesh Deshpande, Pierre Maurel, Olivier Commowick, Christian Barillot, Xavier Tomas-Fernandez, Simon K Warfield, Suthirth Vaidya, Abhijith Chunduru, Ramanathan Muthuganapathy, Ganapathy Krishnamurthi, Andrew Jesson, Tal Arbel, Oskar Maier, Heinz Handels, Leonardo O Iheme, Devrim Unay, Saurabh Jain, Diana M Sima, Dirk Smeets, Mohsen Ghafoorian, Bram Platel, Ariel Birenbaum, Hayit Greenspan, Pierre-Louis Bazin, Peter A Calabresi, Ciprian M Crainiceanu, Lotta M Ellingsen, Daniel S Reich, Jerry L Prince, Dzung L Pham
In conjunction with the ISBI 2015 conference, we organized a longitudinal lesion segmentation challenge providing training and test data to registered participants. The training data consisted of five subjects with a mean of 4.4 time-points, and test data of fourteen subjects with a mean of 4.4 time-points. All 82 data sets had the white matter lesions associated with multiple sclerosis delineated by two human expert raters. Eleven teams submitted results using state-of-the-art lesion segmentation algorithms to the challenge, with ten teams presenting their results at the conference...
January 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28075181/accelerated-or-conventional-whole-brain-irradiation-of-malignant-melanoma
#2
Ragnar Hultborn, Johanna Sand, Sara Kinhult, Lotta Lundgren, Ulrika Stierner, Ingela Turesson, Per Albertsson
No abstract text is available yet for this article.
January 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28054653/the-long-non-coding-rna-neat1-is-responsive-to-neuronal-activity-and-is-associated-with-hyperexcitability-states
#3
Guy Barry, James A Briggs, Do Won Hwang, Sam P Nayler, Patrick R J Fortuna, Nicky Jonkhout, Fabien Dachet, Jesper L V Maag, Pieter Mestdagh, Erin M Singh, Lotta Avesson, Dominik C Kaczorowski, Ezgi Ozturk, Nigel C Jones, Irina Vetter, Luis Arriola-Martinez, Jianfei Hu, Gloria R Franco, Victoria M Warn, Andrew Gong, Marcel E Dinger, Frank Rigo, Leonard Lipovich, Margaret J Morris, Terence J O'Brien, Dong Soo Lee, Jeffrey A Loeb, Seth Blackshaw, John S Mattick, Ernst J Wolvetang
Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long non-coding RNA, NEAT1, directly modulates neuronal excitability and is associated with pathological seizure states. Specifically, NEAT1 is dynamically regulated by neuronal activity in vitro and in vivo, binds epilepsy-associated potassium channel-interacting proteins including KCNAB2 and KCNIP1, and induces a neuronal hyper-potentiation phenotype in iPSC-derived human cortical neurons following antisense oligonucleotide knockdown...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050710/the-copper-bis-thiosemicarbazone-complex-cu-ii-atsm-is-protective-against-cerebral-ischemia-through-modulation-of-the-inflammatory-milieu
#4
Mikko T Huuskonen, Qing-Zhang Tuo, Sanna Loppi, Hiramani Dhungana, Paula Korhonen, Lachlan E McInnes, Paul S Donnelly, Alexandra Grubman, Sara Wojciechowski, Katarina Lejavova, Yuriy Pomeshchik, Laura Periviita, Lotta Kosonen, Martina Giordano, Frederick R Walker, Rong Liu, Ashley I Bush, Jari Koistinaho, Tarja Malm, Anthony R White, Peng Lei, Katja M Kanninen
Developing new therapies for stroke is urgently needed, as this disease is the leading cause of death and disability worldwide, and the existing treatment is only available for a small subset of patients. The interruption of blood flow to the brain during ischemic stroke launches multiple immune responses, characterized by infiltration of peripheral immune cells, the activation of brain microglial cells, and the accumulation of immune mediators. Copper is an essential trace element that is required for many critical processes in the brain...
January 3, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28033261/elevated-thrombopoietin-and-platelet-indices-confirm-active-thrombopoiesis-but-fail-to-predict-clinical-severity-of-puumala-hantavirus-infection
#5
Outi Laine, Lotta Joutsi-Korhonen, Riitta Lassila, Heini Huhtala, Antti Vaheri, Satu Mäkelä, Jukka Mustonen
We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease.Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus-induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030591/aggregated-alpha-synuclein-transfer-efficiently-between-cultured-human-neuron-like-cells-and-localize-to-lysosomes
#6
Jakob Domert, Christopher Sackmann, Emelie Severinsson, Lotta Agholme, Joakim Bergström, Martin Ingelsson, Martin Hallbeck
Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely due to neuron-to-neuron transfer of these aggregates between neuroanatomically connected areas of the brain. As the impact of this pathological spreading mechanism is currently debated, we aimed to investigate the transfer and subcellular location of alpha-synuclein species in a novel 3D co-culture human cell model based on highly differentiated SH-SY5Y cells...
2016: PloS One
https://www.readbyqxmd.com/read/28003803/affective-priming-by-eye-gaze-stimuli-behavioral-and-electrophysiological-evidence
#7
Tingji Chen, Mikko J Peltola, Lotta J Ranta, Jari K Hietanen
The present study employed the affective priming paradigm and measurements of event-related potentials (ERPs) to investigate implicit affective reactions elicited by gaze stimuli. Participants categorized positive and negative words primed by direct gaze, averted gaze and closed eyes. The behavioral response time (RT) results indicated that direct gaze implicitly elicited more positive affective reactions than did closed eyes. Analyses of the ERP responses to the target words revealed a priming effect on the N170 and an interaction on late positive potential (LPP) responses, and congruently with the behavioral results, suggested that, compared to closed eyes, direct gaze was affectively more congruent with positive words and more incongruent with negative words...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27987359/effects-of-apixaban-on-prothrombin-time-activated-partial-thromboplastin-time-and-anti-xa-assays-a-european-survey
#8
Tuukka A Helin, Anja Pakkanen, Riitta Lassila, Lotta Joutsi-Korhonen
No abstract text is available yet for this article.
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27970273/tct-107-ticagelor-is-not-superior-to-clopidogrel-in-patients-with-acute-coronary-syndrome-a-report-from-scaar
#9
Björn Redfors, Sebastian Volz, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Magnus Wahlin, Per Albertsson, Truls Råmunddal, Elmir Omerovic
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969839/tct-482-first-generation-drug-eluting-stent-is-worse-than-contemporary-bare-metal-stent-after-long-term-follow-up-a-report-from-scaar
#10
Sebastian Volz, Christian Dworeck, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Magnus Wahlin, Per Albertsson, Truls Råmunddal, Elmir Omerovic
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969835/tct-477-long-term-risk-of-stent-thrombosis-and-restenosis-after-treatment-with-drug-eluting-stents-a-report-from-scaar
#11
Christian Dworeck, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Sebastian Volz, Per Albertsson, Truls Råmunddal, Elmir Omerovic
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965297/clinical-impact-of-suboptimal-stenting-and-residual-intrastent-plaque-thrombus-protrusion-in-patients-with-acute-coronary-syndrome-the-cli-opci-acs-substudy-centro-per-la-lotta-contro-l-infarto-optimization-of-percutaneous-coronary-intervention-in-acute-coronary
#12
Francesco Prati, Enrico Romagnoli, Laura Gatto, Alessio La Manna, Francesco Burzotta, Ugo Limbruno, Francesco Versaci, Franco Fabbiocchi, Alessandro Di Giorgio, Valeria Marco, Vito Ramazzotti, Luca Di Vito, Carlo Trani, Italo Porto, Alberto Boi, Luigi Tavazzi, Gary S Mintz
BACKGROUND: Clinical consequences of optical coherence tomographic (OCT) high-definition visualization of plaque/stent structures in acute patients remain undefined. In this retrospective substudy, we assessed the prognostic impact of postprocedural culprit lesion OCT findings in patients with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS: In the CLI-OPCI (Centro per la Lotta Contro L'Infarto-Optimization of Percutaneous Coronary Intervention) database collecting cases from 5 independent OCT-experienced centers, we retrospectively analyzed postprocedural OCT findings in acute coronary syndrome patients and explored its possible impact (specifically that of residual intrastent plaque/thrombus protrusion) on outcome...
December 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27927767/t-cells-in-chronic-lymphocytic-leukemia-display-dysregulated-expression-of-immune-checkpoints-and-activation-markers
#13
Marzia Palma, Giusy Gentilcore, Kia Heimersson, Fariba Mozaffari, Barbro Näsman-Glaser, Emma Young, Richard Rosenquist, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to profound T cell defects. T cell functions also depend on co-signaling receptors, inhibitory or stimulatory, known as immune checkpoints, including cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1). Here we analyzed the T cell phenotype focusing on immune checkpoints and activation markers in chronic lymphocytic leukemia patients (n=80) with different clinical characteristics and compared to healthy controls...
December 7, 2016: Haematologica
https://www.readbyqxmd.com/read/27925691/parents-need-support-to-find-ways-to-optimise-their-own-sleep-without-seeing-their-preterm-infant-s-sleeping-patterns-as-a-problem
#14
Ylva Thernström Blomqvist, Kerstin Hedberg Nyqvist, Christine Rubertsson, Eva-Lotta Funkquist
AIM: This study described how parents perceived their own sleep, and their infants', during neonatal intensive care unit (NICU) admission and after discharge. It also explored the infants' sleeping location at home. METHODS: The study was conducted in the NICUs of two Swedish university hospitals. The parents of 86 infants - 86 mothers and 84 fathers - answered questionnaires during their infants' hospital stay, at discharge and at the infants' corrected ages of two, six and 12 months...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27906126/foreword
#15
Lotta Berg, Björn Olsen
No abstract text is available yet for this article.
2016: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/27898682/genetic-predisposition-to-an-impaired-metabolism-of-the-branched-chain-amino-acids-and-risk-of-type-2-diabetes-a-mendelian-randomisation-analysis
#16
Luca A Lotta, Robert A Scott, Stephen J Sharp, Stephen Burgess, Jian'an Luan, Therese Tillin, Amand F Schmidt, Fumiaki Imamura, Isobel D Stewart, John R B Perry, Luke Marney, Albert Koulman, Edward D Karoly, Nita G Forouhi, Rasmus J O Sjögren, Erik Näslund, Juleen R Zierath, Anna Krook, David B Savage, Julian L Griffin, Nishi Chaturvedi, Aroon D Hingorani, Kay-Tee Khaw, Inês Barroso, Mark I McCarthy, Stephen O'Rahilly, Nicholas J Wareham, Claudia Langenberg
BACKGROUND: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human genetic analyses to address this question. METHODS AND FINDINGS: Genome-wide studies of BCAA levels in 16,596 individuals revealed five genomic regions associated at genome-wide levels of significance (p < 5 × 10-8)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27894341/abdominal-obesity-gender-and-the-risk-of-rheumatoid-arthritis-a-nested-case-control-study
#17
Lotta Ljung, Solbritt Rantapää-Dahlqvist
BACKGROUND: The risk of development of rheumatoid arthritis (RA) could be affected by immune activation in obesity. Our objective was to evaluate the association between obesity in general, and abdominal obesity, and the risk for subsequent development of RA. METHODS: In two large population-based, prospective cohorts, 557 cases (mean age at RA symptom onset 58, SD 10 years, 68% women) who subsequently developed RA and 1671 matched controls were identified. From a health examination antedating symptom onset (median 5...
November 29, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27894205/outcomes-of-second-line-treatment-in-chronic-lymphocytic-leukemia-a-population-based-study-from-a-well-defined-geographical-region-between-2003-and-2013
#18
Anna Asklid, Maria Winqvist, Sandra Eketorp Sylvan, Agnes Mattsson, Einar Björgvinsson, Frans Søltoft, Johanna Repits, Joris Diels, Anders Österborg, Lotta Hansson
No abstract text is available yet for this article.
November 28, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27890395/the-recommodification-of-healthcare-a-case-study-of-user-charges-and-inequalities-in-access-to-healthcare-in-sweden-1980-2005
#19
Kristin Farrants, Clare Bambra, Lotta Nylen, Adetayo Kasim, Bo Burström, David Hunter
BACKGROUND: User charges in Swedish healthcare have increased during recent decades. This can be seen in terms of the recommodification of healthcare: making healthcare access more dependent on market position. This study investigates whether the increase in user charges had an impact on educational inequalities in access to healthcare in Sweden between 1980 and 2005. METHODS: Data from the Swedish Living Conditions Survey were used to calculate the odds ratios of access to healthcare for the low and higher educated in Sweden, and the results were stratified by health status (Good and Not good health) for each year 1980-2005...
January 2017: Health Policy
https://www.readbyqxmd.com/read/27856675/metabolism-and-phospholipid-assembly-of-polyunsaturated-fatty-acids-in-human-bone-marrow-mesenchymal-stromal-cells
#20
Feven Tigistu-Sahle, Milla Lampinen, Lotta Kilpinen, Minna Holopainen, Petri Lehenkari, Saara Laitinen, Reijo Käkelä
High arachidonic acid (20:4n-6) and low n-3 PUFA levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune functions. The capacity of the hBMSCs to modify PUFA structures was found to be limited. Therefore, different PUFA supplements given to the cells resulted in very different glycerophospholipid (GPL) species profiles and substrate availability for phospholipases, which have preferences for polar head group and acyl chains when liberating PUFA precursors for production of lipid mediators...
January 2017: Journal of Lipid Research
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