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https://www.readbyqxmd.com/read/28523549/dna-methylation-in-schizophrenia
#1
Lotta-Katrin Pries, Sinan Gülöksüz, Gunter Kenis
Schizophrenia is a highly heritable psychiatric condition that displays a complex phenotype. A multitude of genetic susceptibility loci have now been identified, but these fail to explain the high heritability estimates of schizophrenia. In addition, epidemiologically relevant environmental risk factors for schizophrenia may lead to permanent changes in brain function. In conjunction with genetic liability, these environmental risk factors-likely through epigenetic mechanisms-may give rise to schizophrenia, a clinical syndrome characterized by florid psychotic symptoms and moderate to severe cognitive impairment...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28515779/higher-resource-level-promotes-virulence-in-an-environmentally-transmitted-bacterial-fish-pathogen
#2
Hanna Kinnula, Johanna Mappes, Janne K Valkonen, Katja Pulkkinen, Lotta-Riina Sundberg
Diseases have become a primary constraint to sustainable aquaculture, but remarkably little attention has been paid to a broad class of pathogens: the opportunists. Opportunists often persist in the environment outside the host, and their pathogenic features are influenced by changes in the environment. To test how environmental nutrient levels influence virulence, we used strains of Flavobacterium columnare, an environmentally transmitted fish pathogen, to infect rainbow trout and zebra fish in two different nutrient concentrations...
June 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28514687/particulate-array-of-well-ordered-hiv-clade-c-env-trimers-elicits-neutralizing-antibodies-that-display-a-unique-v2-cap-approach
#3
Paola Martinez-Murillo, Karen Tran, Javier Guenaga, Gustaf Lindgren, Monika Àdori, Yu Feng, Ganesh E Phad, Néstor Vázquez Bernat, Shridhar Bale, Jidnyasa Ingale, Viktoriya Dubrovskaya, Sijy O'Dell, Lotta Pramanik, Mats Spångberg, Martin Corcoran, Karin Loré, John R Mascola, Richard T Wyatt, Gunilla B Karlsson Hedestam
The development of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushered in a new era in HIV-1 vaccination. The recently reported native, flexibly linked (NFL) design allows the generation of native-like trimers from clinical isolates at high yields and homogeneity. As the majority of infections world-wide are of the clade C subtype, we examined responses in non-human primates to well-ordered subtype C 16055 trimers administered in soluble or high-density liposomal formats...
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28511292/gut-inflammation-in-hla-b27-transgenic-rats-alters-the-monocyte-compartment-and-its-osteoclastogenic-potential
#4
Cecilia Ansalone, Lotta Utriainen, Simon Milling, Carl S Goodyear
Objective To investigate the relationship between intestinal inflammation and the central and peripheral innate immune system, in the pathogenesis of HLA-B27 associated spondyloarthritis. Methods The myeloid compartment of the bone marrow and blood of HLA-B27 transgenic (B27), control HLA-B7 transgenic (B7), and non-transgenic rats were evaluated by flow cytometry. Plasma from rats were assessed by ELISA for CCL2 and IL-1α levels. Rats were treated for 4 weeks with antibiotics and the blood and bone marrow myeloid compartments were evaluated by flow cytometry...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28506741/evaluation-of-a-sound-environment-intervention-in-an-icu-a-feasibility-study
#5
Lotta Johansson, Berit Lindahl, Susanne Knutsson, Mikael Ögren, Kerstin Persson Waye, Mona Ringdal
BACKGROUND: Currently, it is well known that the sound environment in intensive care units (ICU) is substandard. Therefore, there is a need of interventions investigating possible improvements. Unfortunately, there are many challenges to consider in the design and performance of clinical intervention studies including sound measurements and clinical outcomes. OBJECTIVES: (1) explore whether it is possible to implement a full-scale intervention study in the ICU concerning sound levels and their impact on the development of ICU delirium; (2) discuss methodological challenges and solutions for the forthcoming study; (3) conduct an analysis of the presence of ICU delirium in the study group; and (4) describe the sound pattern in the intervention rooms...
May 12, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28501802/stability-of-proteins-in-dried-blood-spot-biobanks
#6
Johan Björkesten, Stefan Enroth, Qiujin Shen, Lotta Wik, David Hougaard, Arieh Cohen, Lene Sörensen, Vilmantas Giedraitis, Martin Ingelsson, Anders Larsson, Masood Kamali-Moghaddam, Ulf Landegren
An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples are collected and stored under conditions that preserve potential biomarkers. Dried blood samples are attractive for biobanking because of the ease and low cost of collection and storage. Here we have investigated their suitability for protein measurements...
May 13, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28491937/longitudinal-multiple-sclerosis-lesion-segmentation-data-resource
#7
Aaron Carass, Snehashis Roy, Amod Jog, Jennifer L Cuzzocreo, Elizabeth Magrath, Adrian Gherman, Julia Button, James Nguyen, Pierre-Louis Bazin, Peter A Calabresi, Ciprian M Crainiceanu, Lotta M Ellingsen, Daniel S Reich, Jerry L Prince, Dzung L Pham
The data presented in this article is related to the research article entitled "Longitudinal multiple sclerosis lesion segmentation: Resource and challenge" (Carass et al., 2017) [1]. In conjunction with the 2015 International Symposium on Biomedical Imaging, we organized a longitudinal multiple sclerosis (MS) lesion segmentation challenge providing training and test data to registered participants. The training data consists of five subjects with a mean of 4.4 (±0.55) time-points, and test data of fourteen subjects with a mean of 4...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28489454/acquisition-and-transmission-of-streptococcus-pneumoniae-is-facilitated-during-rhinovirus-infection-in-families-with-children
#8
Sinikka Karppinen, Johanna Teräsjärvi, Kari Auranen, Linnea Schuez-Havupalo, Lotta Siira, Qiushui He, Matti Waris, Ville Peltola
RATIONALE: Laboratory and clinical evidence suggests synergy between rhinoviruses and Streptococcus pneumoniae in the pathogenesis of respiratory tract infections. However, it is unclear whether rhinoviruses promote pneumococcal acquisition and transmission. OBJECTIVES: To describe the impact of rhinovirus infection on acquisition and transmission of pneumococci within families with children. METHODS: We investigated 29 families with at least two children...
May 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28482768/leadership-quality-a-factor-important-for-social-capital-in-healthcare-organizations
#9
Marcus Strömgren, Andrea Eriksson, Linda Ahlstrom, David Kristofer Bergman, Lotta Dellve
Purpose The purpose of this paper is to investigate the relation between leadership and social capital and what qualities of leadership are important for social capital among employees in hospital settings over time. Design/methodology/approach A cohort of employees in hospitals answered a questionnaire at three occasions. Five small (approx. 100-bed) or mid-sized (approx. 500-bed) hospitals were included. The response rate was 54 percent at baseline ( n=865), 59 percent at one-year follow-up ( n=908) and 67 percent at two-year follow-up ( n=632)...
April 10, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28481305/synthesis-of-aminoglycoside-2-o-methyl-oligoribonucleotide-fusions
#10
Lotta Granqvist, Andrzej Kraszewski, Ville Tähtinen, Pasi Virta
Phosphoramidite building blocks of ribostamycin (3 and 4), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified solid support, were applied for the preparation of aminoglycoside-2'-O-methyl oligoribonucleotide fusions. The fusions were used to clamp a single strand DNA sequence (a purine-rich strand of c-Myc promoter 1) to form triple helical 2'-O-methyl RNA/DNA-hybrid constructs. The potential of the aminoglycoside moieties to stabilize the triple helical constructs were studied by UV-melting profile analysis...
May 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28480542/the-effect-of-non-steroidal-anti-inflammatory-drugs-on-risk-of-benign-prostatic-hyperplasia
#11
Lotta H Nygård, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
BACKGROUND: Inflammation may play a role in pathogenesis of benign prostatic hyperplasia (BPH). However, the role of non-steroidal anti-inflammatory drugs (NSAIDs) as BPH risk factor is unclear. The objective of this study was to examine risk of BPH by NSAID use in a population-based cohort. METHODS: A total of 74 754 Finnish men without previous BPH at baseline in 1996-1999 were linked to national medication reimbursement database for information on physician-prescribed NSAID purchases during 1995-2009...
June 2017: Prostate
https://www.readbyqxmd.com/read/28475240/association-of-pain-ratings-with-the-prediction-of-early-physical-recovery-after-general-and-orthopaedic-surgery-a-quantitative-study-with-repeated-measures
#12
Kerstin Eriksson, Lotta Wikström, Bengt Fridlund, Kristofer Årestedt, Anders Broström
AIM: To compare different levels of self-rated pain and determine if they predict anticipated early physical recovery in patients undergoing general and orthopaedic surgery. BACKGROUND: Previous research has indicated that average self-rated pain reflects patients' ability to recover the same day. However, there is a knowledge gap about the feasibility of using average pain ratings to predict patients' physical recovery for the next day. DESIGN: Descriptive, quantitative repeated measures...
May 5, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28465458/socioeconomic-status-and-the-risk-of-stroke-recurrence-persisting-gaps-observed-in-a-nationwide-swedish-study-2001-to-2012
#13
Johanna Pennlert, Kjell Asplund, Eva-Lotta Glader, Bo Norrving, Marie Eriksson
BACKGROUND AND PURPOSE: This nationwide observational study aimed to investigate how socioeconomic status is associated with risk of stroke recurrence and how possible associations change over time. METHODS: This study included 168 295 patients, previously independent in activities of daily living, with a first-ever stroke in the Swedish Stroke Register (Riksstroke) 2001 to 2012. Riksstroke was linked with Statistics Sweden as to add individual information on education and income...
May 2, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28445515/correlation-of-histopathologic-characteristics-to-protein-expression-and-function-in-malignant-melanoma
#14
Charlotte Welinder, Krzysztof Pawłowski, A Marcell Szasz, Maria Yakovleva, Yutaka Sugihara, Johan Malm, Göran Jönsson, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Melinda Rezeli, Thomas Laurell, Elisabet Wieslander, György Marko-Varga
BACKGROUND: Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patients, tumors, and samples themselves. With the long term aim of quest for better diagnostics biomarkers, as well as predictive and prognostic markers, we focused on relating high resolution proteomics data to careful histopathological evaluation of the tumor samples and patient survival information...
2017: PloS One
https://www.readbyqxmd.com/read/28428555/application-of-high-resolution-melting-assay-hrm-to-study-temperature-dependent-intraspecific-competition-in-a-pathogenic-bacterium
#15
Roghaieh Ashrafi, Matthieu Bruneaux, Lotta-Riina Sundberg, Katja Pulkkinen, Tarmo Ketola
Studies on species' responses to climate change have focused largely on the direct effect of abiotic factors and in particular temperature, neglecting the effects of biotic interactions in determining the outcome of climate change projections. Many microbes rely on strong interference competition; hence the fitness of many pathogenic bacteria could be a function of both their growth properties and intraspecific competition. However, due to technical challenges in distinguishing and tracking individual strains, experimental evidence on intraspecific competition has been limited so far...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427441/physical-activity-among-children-objective-measurements-using-fitbit-one-%C3%A2-and-actigraph
#16
Lotta Hamari, Tiina Kullberg, Jukka Ruohonen, Olli J Heinonen, Natalia Díaz-Rodríguez, Johan Lilius, Anni Pakarinen, Annukka Myllymäki, Ville Leppänen, Sanna Salanterä
BACKGROUND: Self-quantification of health parameters is becoming more popular; thus, the validity of the devices requires assessments. The aim of this study was to evaluate the validity of Fitbit One step counts (Fitbit Inc., San Francisco, CA, USA) against Actigraph wActisleep-BT step counts (ActiGraph, LLC, Pensacola, FL, USA) for measuring habitual physical activity among children. DESIGN: The study was implemented as a cross-sectional experimental design in which participants carried two waist-worn activity monitors for five consecutive days...
April 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28413705/acute-stroke-alert-activation-emergency-service-use-and-reperfusion-therapy-in-sweden
#17
Marie Eriksson, Eva-Lotta Glader, Bo Norrving, Birgitta Stegmayr, Kjell Asplund
OBJECTIVES: Ambulance services and stroke alerts reduce the time from stroke onset to acute stroke diagnosis. We describe the use of stroke alerts and ambulance services in different hospitals and patient groups and their relationship with reperfusion therapy. METHODS: This nationwide study included 49,907 patients admitted with acute stroke who were registered in The Swedish Stroke Register (Riksstroke) in 2011-2012. RESULTS: The proportions of patients admitted as stroke alerts out of all acute stroke admissions varied from 12...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28402687/seat-belt-pre-pretensioner-effect-on-child-sized-dummies-during-run-off-road-events
#18
Isabelle Stockman, Katarina Bohman, Lotta Jakobsson
OBJECTIVE: Run-off-road events occur frequently and can result in severe consequences. Several potential injury-causing mechanisms can be observed in the diverse types of run-off-road events. Real-world data show that different types of environments, such as rough terrain, ditch types, and whether multiple events occur, may be important contributing factors to occupant injury. Though countermeasures addressing front seat occupants have been presented, studies on rear seat occupant retention in situations such as run-off-road events are lacking...
April 12, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28399411/inhibition-of-hematopoietic-cell-kinase-activity-suppresses-myeloid-cell-mediated-colon-cancer-progression
#19
Ashleigh R Poh, Christopher G Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L Putoczki, Robert J J O'Donoghue, Matthias Ernst
Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorectal cancer patients. Likewise, increased Hck activity in mice promotes the growth of endogenous colonic malignancies and of human colorectal cancer cell xenografts. Furthermore, tumor-associated macrophages of the corresponding tumors show a pronounced alternatively activated endotype, which occurs independently of mature lymphocytes or of Stat6-dependent Th2 cytokine signaling...
April 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28370485/19f-nmr-spectroscopic-analysis-of-the-binding-modes-in-triple-helical-pna-microrna-complexes
#20
Pasi Markus Virta, Ville Tähtinen, Lotta Granqvist, Merita Murtola, Roger Strömberg
Triplex-forming peptide nucleic acids (TFPNAs) were targeted to double helical regions of 19F-labelled RNA hairpin models (a UA-rich duplex with a hexaethylene glycol (heg) loop and a miR-215 model). In addition to the conventional UV- and CD-based detection, the binding was monitored by 19F NMR spectroscopy. Detailed information considering the stoichiometry and transition between the triple helical PNA/RNA- and (PNA)2/RNA-binding modes could be obtained. γ-(R)-hydroxymethyl-modified (thymine-1-yl- and 2-aminopyridin-3-yl-acetyl derivatives) TFPNAs were additionally synthesized, targeted to the same RNA models and the effect of the γ-(R)-hydroxymethyl group on the binding was studied...
March 28, 2017: Chemistry: a European Journal
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