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https://www.readbyqxmd.com/read/28725159/importance-of-social-capital-at-the-workplace-for-return-to-work-among-women-with-a-history-of-long-term-sick-leave-a-cohort-study
#1
Ingela Rydström, Lotta Dalheim Englund, Lotta Dellve, Linda Ahlstrom
BACKGROUND: The workplace is an essential source of social capital for many people; it provides mutual support and gives meaning to life. However, few prospective studies have thoroughly investigated the importance of aspects of social capital in the workplace. The aim of this study was to investigate the associations between aspects of social capital (social support, sense of community, and quality of leadership) at the workplace, and work ability, working degree, and vitality among women with a history of long-term sick leave from human service organizations...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28716906/virus-found-in-a-boreal-lake-links-ssdna-and-dsdna-viruses
#2
Elina Laanto, Sari Mäntynen, Luigi De Colibus, Jenni Marjakangas, Ashley Gillum, David I Stuart, Janne J Ravantti, Juha T Huiskonen, Lotta-Riina Sundberg
Viruses have impacted the biosphere in numerous ways since the dawn of life. However, the evolution, genetic, structural, and taxonomic diversity of viruses remain poorly understood, in part because sparse sampling of the virosphere has concentrated mostly on exploring the abundance and diversity of dsDNA viruses. Furthermore, viral genomes are highly diverse, and using only the current sequence-based methods for classifying viruses and studying their phylogeny is complicated. Here we describe a virus, FLiP (Flavobacterium-infecting, lipid-containing phage), with a circular ssDNA genome and an internal lipid membrane enclosed in the icosahedral capsid...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715366/continuous-wave-thulium-laser-for-heating-cultured-cells-to-investigate-cellular-thermal-effects
#3
Yoko Miura, Joachim Pruessner, Carla Lotta Mertineit, Katharina Kern, Michael Muenter, Moritz Moltmann, Veit Danicke, Ralf Brinkmann
An original method to heat cultured cells using a 1.94 µm continuous-wave thulium laser for biological assessment is introduced here. Thulium laser radiation is strongly absorbed by water, and the cells at the bottom of the culture dish are heated through thermal diffusion. A laser fiber with a diameter of 365 µm is set about 12 cm above the culture dish, without any optics, such that the laser beam diameter is almost equivalent to the inner diameter of the culture dish (30 mm). By keeping a consistent amount of culture medium in each experiment, it is possible to irradiate the cells with a highly reproducible temperature increase...
June 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28710095/acute-coronary-syndrome-in-new-onset-rheumatoid-arthritis-a-population-based-nationwide-cohort-study-of-time-trends-in-risks-and-excess-risks
#4
Marie Holmqvist, Lotta Ljung, Johan Askling
BACKGROUND: Acute coronary syndrome (ACS) and other cardiovascular diseases are the main drivers of the increased morbidity and preterm mortality in rheumatoid arthritis (RA). ACS in RA has been linked to inflammation and RA severity. During recent years and with new therapeutic options and treat-to-target strategies, increasing efforts have been made to reach RA remission as soon as possible after diagnosis, and the average level of RA disease activity has declined. Whether this has resulted in declining excess risks for RA comorbidities remains unclear...
July 14, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28706114/one-year-incidence-time-trends-and-predictors-of-recurrent-ischemic-stroke-in-sweden-from-1998-to-2010-an-observational-study
#5
Lisa Bergström, Anna-Lotta Irewall, Lars Söderström, Joachim Ögren, Katarina Laurell, Thomas Mooe
BACKGROUND AND PURPOSE: Recent data on the incidence, time trends, and predictors of recurrent ischemic stroke are limited for unselected patient populations. METHODS: Data for ischemic stroke patients were obtained from The Swedish Stroke Register (Riksstroke) between 1998 and 2009 and merged with The Swedish National Inpatient Register. A reference group of patients was created by Statistics Sweden. The ischemic stroke patient cohort was divided into 4 time periods...
July 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28705923/maternal-and-female-fetal-testosterone-levels-are-associated-with-maternal-age-and-gestational-weight-gain
#6
Theodora Kunovac-Kallak, Charlotte Hellgren, Alkistis Skalkidou, Lotta Sandelin-Francke, Kumari Ubhayasekera, Jonas Bergquist, Ove Axelsson, Erika Comasco, Rebecca Campbell, Inger Sundstrom Poromaa
OBJECTIVE: Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood, and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses...
July 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28702322/mitochondrial-transcription-factor-b2-is-essential-for-mitochondrial-and-cellular-function-in-pancreatic-%C3%AE-cells
#7
Lisa M Nicholas, Bérengère Valtat, Anya Medina, Lotta Andersson, Mia Abels, Inês G Mollet, Deepak Jain, Lena Eliasson, Nils Wierup, Malin Fex, Hindrik Mulder
OBJECTIVE: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial transcription factor B2 (TFB2M) controls transcription of mitochondrial-encoded genes. However, its precise role in mitochondrial metabolism in pancreatic β-cells and, consequently, in insulin secretion remains unknown. METHODS: To elucidate the role of TFB2M in mitochondrial function and insulin secretion in vitro and in vivo, mice with a β-cell specific homozygous or heterozygous knockout of Tfb2m and rat clonal insulin-producing cells in which the gene was silenced were examined with an array of metabolic and functional assays...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28686890/assessing-the-use-of-%C3%AE-18-o-in-phosphate-as-a-tracer-for-catchment-phosphorus-sources
#8
Karin Tonderski, Lotta Andersson, Göran Lindström, Rasmus St Cyr, Ronny Schönberg, Heinrich Taubald
Procedures for source apportionment of nutrients transported in rivers and streams are often uncertain and difficult to validate. In this study, we investigated if the oxygen isotope ratios in stream dissolved phosphate (δ(18)OP) can be used to distinguish between the phosphorus (P) originating from agricultural runoff and from rural sewage, at different periods of the year. Water was collected from septic tanks, drainage wells and the stream outlet in a small (7.3 km(2)) agricultural catchment to capture variations in the isotope signature at different flow events...
July 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28667186/analytically-sensitive-protein-detection-in-microtiter-plates-by-proximity-ligation-with-rolling-circle-amplification
#9
Tonge Ebai, Felipe Marques Souza de Oliveira, Liza Löf, Lotta Wik, Caroline Schweiger, Anders Larsson, Ulrich Keilholtz, Johannes Haybaeck, Ulf Landegren, Masood Kamali-Moghaddam
BACKGROUND: Detecting proteins at low concentrations in plasma can be crucial for early diagnosis. Current techniques used in clinical routine, such as sandwich ELISA, provide for protein detection because of a dependence on target recognition by pairs of antibodies, but detection of low protein concentrations is often called for. Proximity ligation assay with rolling circle amplification (PLARCA) is an adaptation of the proximity ligation assay (PLA) for analytically specific and sensitive protein detection via binding of target proteins by 3 antibodies, and signal amplification via rolling circle amplification (RCA) in microtiter wells, in a manner easily adapted to instrumentation in use in hospitals...
June 30, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28666077/is-rheumatoid-arthritis-a-mortal-disease
#10
EDITORIAL
Johan Askling, Marie Holmqvist, Lotta Ljung
No abstract text is available yet for this article.
June 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28665354/a-validation-study-of-an-interviewer-administered-short-food-frequency-questionnaire-in-assessing-dietary-vitamin-d-and-calcium-intake-in-swedish-children
#11
Lotta Söderberg, Torbjörn Lind, Pia Karlsland Åkeson, Ann-Kristin Sandström, Olle Hernell, Inger Öhlund
Vitamin D and calcium are essential nutrients with a range of biological effects of public health relevance. This study aimed to validate a short food frequency questionnaire (SFFQ) against a three-day food record (3D record), assessing the intake of vitamin D and calcium in Swedish children during wintertime. In a double-blinded, randomized food-based intervention study on the effect of feeding different daily doses of vitamin D supplement to 5-7-year-old children (n = 85), 79 (93%) participants completed SFFQ1 at baseline and SFFQ2 after the intervention, and 72 were informed to fill in a 3D record...
June 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28631856/tetrameric-and-dimeric-n%C3%A2-%C3%A2-%C3%A2-i-%C3%A2-%C3%A2-%C3%A2-n-halogen-bonded-supramolecular-cages
#12
Kari Rissanen, Lotta Turunen, Anssi Peuronen, Samu Forsblom, Elina Kalenius, Manu Lahtinen
Tripodal N-donor ligands are used to form halogen-bonded assemblies via structurally analogous Ag+-complexes. Selective formation of discrete tetrameric I6L4 and dimeric I3L2 halonium cages, wherein multiple [N∙∙∙I+∙∙∙N] halogen bonds are used in concert, can be achieved by using sterically rigidified cationic tris(1-methyl-1-azonia-4-azabicyclo[2.2.2]octane)-mesitylene ligand, L1(PF6)3, and flexible ligand 1,3,5-tris(imidazole-1-ylmethyl)-2,4,6-trimethylbenzene, L2, respectively. The iodonium cages, I6L14(PF6)18 and I3L22(PF6)3, were obtained through the [N∙∙∙Ag+∙∙∙N] → [N∙∙∙I+∙∙∙N] cation exchange reaction between the corresponding Ag6L14(PF6)18 and Ag3L22(PF6)3 coordination cages, prepared as intermediates, and I2...
June 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28611769/analysis-of-complement-c3-gene-reveals-susceptibility-to-severe-preeclampsia
#13
A Inkeri Lokki, Tea Kaartokallio, Ville Holmberg, Päivi Onkamo, Lotta L E Koskinen, Päivi Saavalainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Pia M Villa, Leena Hiltunen, Hannele Laivuori, Seppo Meri
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, C3. Three cohorts of Finnish patients and controls were recruited for a genetic case-control study. Participants were genotyped using Sequenom genotyping and Sanger sequencing. Initially, we studied 259 Finnish patients with severe PE and 426 controls from the Southern Finland PE and the Finnish population-based PE cohorts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28596384/complete-genome-sequence-of-an-aquaculture-associated-phage-fl-1-infecting-flavobacterium-spp
#14
Elina Laanto, Janne J Ravantti, Lotta-Riina Sundberg
FL-1, a myophage of Flavobacterium, was found to have a 53-kb genome with 87 putative coding sequences.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28591156/dark-eyes-in-female-sand-gobies-indicate-readiness-to-spawn
#15
Karin H Olsson, Sandra Johansson, Eva-Lotta Blom, Kai Lindström, Ola Svensson, Helen Nilsson Sköld, Charlotta Kvarnemo
In animals, colorful and conspicuous ornaments enhance individual attractiveness to potential mates, but are typically tempered by natural selection for crypsis and predator protection. In species where males compete for females, this can lead to highly ornamented males competing for mating opportunities with choosy females, and vice versa. However, even where males compete for mating opportunities, females may exhibit conspicuous displays. These female displays are often poorly understood and it may be unclear whether they declare mating intent, signal intrasexual aggression or form a target for male mate preference...
2017: PloS One
https://www.readbyqxmd.com/read/28576708/a-systems-level-analysis-of-epileptogenesis-associated-proteome-alterations
#16
Michael Keck, Ganna Androsova, Fabio Gualtieri, Andreas Walker, Eva-Lotta von Rüden, Vera Russmann, Cornelia A Deeg, Stefanie M Hauck, Roland Krause, Heidrun Potschka
Despite intense research efforts, the knowledge about the mechanisms of epileptogenesis and epilepsy is still considered incomplete and limited. However, an in-depth understanding of molecular pathophysiological processes is crucial for the rational selection of innovative biomarkers and target candidates. Here, we subjected proteomic data from different phases of a chronic rat epileptogenesis model to a comprehensive systems level analysis. Weighted Gene Co-expression Network analysis identified several modules of interconnected protein groups reflecting distinct molecular aspects of epileptogenesis in the hippocampus and the parahippocampal cortex...
May 30, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28574956/identifying-high-alert-medications-in-a-university-hospital-by-applying-data-from-the-medication-error-reporting-system
#17
Lotta Tyynismaa, Anni Honkala, Marja Airaksinen, Kenneth Shermock, Lasse Lehtonen
OBJECTIVES: To facilitate safe use of high-alert medications, lists of medications posing higher risks for medication errors (MEs) and harmful effects have been compiled. These lists can be general or reflect clinical practices in specific settings. Less common has been to compile a hospital-specific list applying data from the organization's ME reporting system. Our objective was to demonstrate a method for compiling such a high-alert medication list in a university hospital. METHODS: Of the eighteen 136 MEs reported during 2007 to 2013, ME reports with medications coded as a contributing factor to the incident were included (n = 249)...
June 1, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28566443/hypoinsulinaemic-hypoketotic-hypoglycaemia-due-to-mosaic-genetic-activation-of-pi3-kinase
#18
Sarah M Leiter, Victoria E R Parker, Alena Welters, Rachel Knox, Nuno Rocha, Graeme Clark, Felicity Payne, Luca Lotta, Julie Harris, Julio Guerrero-Fernández, Isabel González-Casado, Sixto García-Miñaur, Gema Gordo, Nick Wareham, Víctor Martínez-Glez, Michael Allison, Stephen O'Rahilly, Inês Barroso, Thomas Meissner, Susan Davies, Khalid Hussain, Karen Temple, Ana-Coral Barreda-Bonis, Sebastian Kummer, Robert K Semple
OBJECTIVE: Genetic activation of the insulin signal-transducing kinase AKT2 causes syndromic hypoketotic hypoglycaemia without elevated insulin. Mosaic activating mutations in class 1A phospatidylinositol-3-kinase (PI3K), upstream from AKT2 in insulin signalling, are known to cause segmental overgrowth, but the metabolic consequences have not been systematically reported. We assess the metabolic phenotype of 22 patients with mosaic activating mutations affecting PI3K, thereby providing new insight into the metabolic function of this complex node in insulin signal transduction...
August 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28523549/dna-methylation-in-schizophrenia
#19
Lotta-Katrin Pries, Sinan Gülöksüz, Gunter Kenis
Schizophrenia is a highly heritable psychiatric condition that displays a complex phenotype. A multitude of genetic susceptibility loci have now been identified, but these fail to explain the high heritability estimates of schizophrenia. In addition, epidemiologically relevant environmental risk factors for schizophrenia may lead to permanent changes in brain function. In conjunction with genetic liability, these environmental risk factors-likely through epigenetic mechanisms-may give rise to schizophrenia, a clinical syndrome characterized by florid psychotic symptoms and moderate to severe cognitive impairment...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28515779/higher-resource-level-promotes-virulence-in-an-environmentally-transmitted-bacterial-fish-pathogen
#20
Hanna Kinnula, Johanna Mappes, Janne K Valkonen, Katja Pulkkinen, Lotta-Riina Sundberg
Diseases have become a primary constraint to sustainable aquaculture, but remarkably little attention has been paid to a broad class of pathogens: the opportunists. Opportunists often persist in the environment outside the host, and their pathogenic features are influenced by changes in the environment. To test how environmental nutrient levels influence virulence, we used strains of Flavobacterium columnare, an environmentally transmitted fish pathogen, to infect rainbow trout and zebra fish in two different nutrient concentrations...
June 2017: Evolutionary Applications
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