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https://www.readbyqxmd.com/read/28630968/designing-self-powered-materials-systems-that-perform-pattern-recognition
#1
Yan Fang, Victor V Yashin, Steven P Levitan, Anna C Balazs
Inspired by the advances in both materials and computer science, we describe efforts to design "materials that compute" where the material and the computer are the same entity. Using theory and simulation, we devise systems that integrate the behavior of self-oscillating gels and fundamental concepts from oscillator-based computing. We specifically focus on gels that undergo the Belousov-Zhabotinsky (BZ) reaction and thus exhibit self-sustained oscillations. In our models, we couple the BZ gel to an overlaying piezoelectric (PZ) cantilever to create a BZ-PZ unit...
June 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28621991/new-approaches-to-coding-information-using-inverse-scattering-transform
#2
L L Frumin, A A Gelash, S K Turitsyn
Remarkable mathematical properties of the integrable nonlinear Schrödinger equation (NLSE) can offer advanced solutions for the mitigation of nonlinear signal distortions in optical fiber links. Fundamental optical soliton, continuous, and discrete eigenvalues of the nonlinear spectrum have already been considered for the transmission of information in fiber-optic channels. Here, we propose to apply signal modulation to the kernel of the Gelfand-Levitan-Marchenko equations that offers the advantage of a relatively simple decoder design...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28605807/visual-sensory-and-visual-cognitive-function-and-rate-of-crash-and-near-crash-involvement-among-older-drivers-using-naturalistic-driving-data
#3
Carrie Huisingh, Emily B Levitan, Marguerite R Irvin, Paul MacLennan, Virginia Wadley, Cynthia Owsley
Purpose: An innovative methodology using naturalistic driving data was used to examine the association between visual sensory and visual-cognitive function and rates of future crash or near-crash involvement among older drivers. Methods: The Strategic Highway Research Program (SHRP2) Naturalistic Driving Study was used for this prospective analysis. The sample consisted of N = 659 drivers aged ≥70 years and study participation lasted 1 or 2 years for most participants...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28600320/limited-distal-organelles-and-synaptic-function-in-extensive-monoaminergic-innervation
#4
Juan Tao, Dinara Bulgari, David L Deitcher, Edwin S Levitan
Organelles such as neuropeptide-containing dense-core vesicles (DCVs) and mitochondria travel down axons to supply synaptic boutons. DCV distribution among en passant boutons in small axonal arbors is mediated by circulation with bidirectional capture. However, it is not known how organelles are distributed in extensive arbors associated with volume transmission and neuromodulation by monoamines and neuropeptides and mammalian dopamine neuron vulnerability. Therefore, we studied presynaptic organelle distribution in Drosophila octopamine neurons that innervate ∼20 muscles with ∼1500 boutons...
June 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28521765/inhibition-of-o-glcnacase-leads-to-elevation-of-o-glcnac-tau-and-reduction-of-tauopathy-and-cerebrospinal-fluid-tau-in-rtg4510-mice
#5
Nicholas B Hastings, Xiaohai Wang, Lixin Song, Brent D Butts, Diane Grotz, Richard Hargreaves, J Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J McEachern, Xuesong Ouyang, Thomas W Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J Vocadlo, Ganfeng Wang, Joseph L Duffy, Eric M Parker, Lili Zhang
BACKGROUND: Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modification of tau that involves the addition of N-acetylglucosamine onto serine and threonine residues. Inhibition of O-GlcNAcase (OGA), the enzyme responsible for the removal of O-GlcNAc modification, has been shown to reduce tau pathology in several transgenic models...
May 18, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28492415/anticoagulation-control-in-patients-with-ventricular-assist-devices
#6
Amelia K Boehme, Salpy V Pamboukian, James F George, T Mark Beasley, James K Kirklin, Jose Tallaj, Chrisly Dillon, Emily B Levitan, Russell Griffin, Gerald McGwin, William B Hillegass, Nita A Limdi
Anticoagulation control has been associated with risk of thromboembolism and hemorrhage. Herein, we explore the relationship between anticoagulation control achieved in left ventricular assist device (LVAD) patients and evaluate the association with risk of thromboembolism and hemorrhage. Patients (19 years old or older) with a continuous flow LVAD placed from 2006 to 2012. Proportion of time spent in target range (PTTR) for international normalized ratio (INR) was estimated with target range of 2.0-3.0. Proportion of time spent in target range was categorized into PTTR > 60%, PTTR ≥ 50 < 60%, and PTTR < 50%...
May 9, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28487663/binge-eating-disorder-bed-in-relation-to-addictive-behaviors-and-personality-risk-factors
#7
Caroline Davis, Laura Mackew, Robert D Levitan, Allan S Kaplan, Jacqueline C Carter, James L Kennedy
While there is good evidence that binge eating disorder (BED) is linked to higher-than-expected use of a broad range of addictive behaviors, mechanisms underlying this association are not well understood. Using a mediation-analytical approach with three age- and gender-matched groups - overweight/obese adults with (n = 42) and without (n = 104) BED, and normal-weight control participants (n = 73) - we tested the hypothesis that adults with BED would engage in more addictive behaviors and have higher scores on a personality-risk index than the two control groups...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28468785/comparison-of-expert-adjudicated-coronary-heart-disease-and-cardiovascular-disease-mortality-with-the-national-death-index-results-from-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#8
Olusola Tope Olubowale, Monika M Safford, Todd M Brown, Raegan W Durant, Virginia J Howard, Christopher Gamboa, Stephen P Glasser, J David Rhodes, Emily B Levitan
BACKGROUND: The National Death Index (NDI) is widely used to detect coronary heart disease (CHD) and cardiovascular disease (CVD) deaths, but its reliability has not been examined recently. METHODS AND RESULTS: We compared CHD and CVD deaths detected by NDI with expert adjudication of 4010 deaths that occurred between 2003 and 2013 among participants in the REGARDS (REasons for Geographic And Racial Differences in Stroke) cohort of black and white adults in the United States...
May 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28400302/decreased-comfort-food-intake-and-allostatic-load-in-adolescents-carrying-the-a3669g-variant-of-the-glucocorticoid-receptor-gene
#9
Danitsa Marcos Rodrigues, Roberta Sena Reis, Roberta Dalle Molle, Tania Diniz Machado, Amanda Brondani Mucellini, Andressa Bortoluzzi, Rudineia Toazza, Juliano Adams Pérez, Giovanni Abrahão Salum, Marilyn Agranonik, Luciano Minuzzi, Robert D Levitan, Augusto Buchweitz, Alexandre Rosa Franco, Gisele Gus Manfro, Patrícia Pelufo Silveira
BACKGROUND: The A3669G single nucleotide polymorphism (SNP) of the glucocorticoid receptor (GR) gene NR3C1 is associated with altered tissue sensitivity to glucocorticoids (GCs). GCs modulate the food reward circuitry and are implicated in increased intake of palatable foods, which can lead to the metabolic syndrome and obesity. We hypothesized that presence of the G variant of the A3669G SNP would affect preferences for palatable foods and alter metabolic, behavioural, and neural outcomes...
April 8, 2017: Appetite
https://www.readbyqxmd.com/read/28369197/risk-of-acute-coronary-heart-disease-after-sepsis-hospitalization-in-the-reasons-for-geographic-and-racial-differences-in-stroke-cohort
#10
Henry E Wang, Justin X Moore, John P Donnelly, Emily B Levitan, Monika M Safford
BACKGROUND: Sepsis is associated with long-term health consequences. We sought to determine the long-term risks of acute and fatal coronary heart disease (CHD) events after sepsis hospitalizations among community dwelling adults. METHODS: We analyzed data from 30,329 participants in the population-based Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Sepsis events included hospitalizations for a serious infection with ≥2 systemic inflammatory response syndrome (SIRS) criteria...
March 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28259549/insurance-self-reported-medication-adherence-and-ldl-cholesterol-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#11
Matt Mefford, Monika M Safford, Paul Muntner, Raegan W Durant, Todd M Brown, Emily B Levitan
BACKGROUND: Lack of health insurance may adversely impact medication adherence and the control of cardiovascular risk factors. We examined if the association between insurance and LDL-C is due to self-reported low medication adherence. METHODS: This cross-sectional study included 8685 black and white men and women aged 45 and older who participated in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort and used statins. Medication adherence was assessed using the 4-item Morisky Medication Adherence Scale (MMAS-4)...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28247251/giving-patients-preferences-a-voice-in-medical-treatment-life-cycle-the-prefer-public-private-project
#12
EDITORIAL
Esther W de Bekker-Grob, Conny Berlin, Bennett Levitan, Karim Raza, Kalliopi Christoforidi, Irina Cleemput, Jana Pelouchova, Harald Enzmann, Nigel Cook, Mats G Hansson
No abstract text is available yet for this article.
June 2017: Patient
https://www.readbyqxmd.com/read/28168630/airway-management-outside-the-operating-room-how-to-better-prepare
#13
Peter G Brindley, Martin Beed, J Adam Law, Orlando Hung, Richard Levitan, Michael F Murphy, Laura V Duggan
Airway management outside the operating room is associated with increased risks compared with airway management inside the operating room. Moreover, airway management-whether in the intensive care unit, emergency department, interventional radiology suite, or general wards-often requires mastery of not only the anatomically difficult airway but also the physiologically and situationally difficult airway. The 2015 Difficult Airway Society Guidelines encourage the airway team to "stop and think". This article provides a practical review of how that evidence applies during emergency airway management outside of the operating room...
May 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28143858/phenotyping-of-adipose-liver-and-skeletal-muscle-insulin-resistance-and-response-to-pioglitazone-in-spontaneously-obese-rhesus-monkeys
#14
Jin Shang, Stephen F Previs, Stacey Conarello, Keefe Chng, Yonghua Zhu, Sandra C Souza, Michael Staup, Ying Chen, Dan Xie, Emanuel Zycband, Karni Schlessinger, Victoria Plamadeala Johnson, Gladys Arreaza, Franklin Liu, Diane Levitan, Liangsu Wang, Margaret van Heek, Mark Erion, Yixin Wang, David E Kelley
Insulin resistance and diabetes can develop spontaneously with obesity and aging in rhesus monkeys, highly similar to the natural history of obesity, insulin resistance, and progression to type 2 diabetes in humans. The current studies in obese rhesus were undertaken to assess hepatic and adipose contributions to systemic insulin resistance-currently, a gap in our knowledge-and to benchmark the responses to pioglitazone (PIO). A two-step hyperinsulinemic-euglycemic clamp, with tracer-based glucose flux estimates, was used to measure insulin resistance, and in an intervention study was repeated following 6 wk of PIO treatment (3 mg/kg)...
April 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28129919/loss-of-huntingtin-stimulates-capture-of-retrograde-dense-core-vesicles-to-increase-synaptic-neuropeptide-stores
#15
Dinara Bulgari, David L Deitcher, Edwin S Levitan
The Huntington's disease protein Huntingtin (Htt) regulates axonal transport of dense-core vesicles (DCVs) containing neurotrophins and neuropeptides. DCVs travel down axons to reach nerve terminals where they are either captured in synaptic boutons to support later release or reverse direction to reenter the axon as part of vesicle circulation. Currently, the impact of Htt on DCV dynamics in the terminal is unknown. Here we report that knockout of Drosophila Htt selectively reduces retrograde DCV flux at proximal boutons of motoneuron terminals...
January 22, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28122218/molecular-scale-biophysical-modulation-of-an-endothelial-membrane-by-oxidized-phospholipids
#16
Manuela A A Ayee, Elizabeth LeMaster, Tzu Pin Shentu, Dev K Singh, Nicolas Barbera, Dheeraj Soni, Chinnaswamy Tiruppathi, Papasani V Subbaiah, Evgeny Berdyshev, Irina Bronova, Michael Cho, Belinda S Akpa, Irena Levitan
The influence of two bioactive oxidized phospholipids on model bilayer properties, membrane packing, and endothelial cell biomechanics was investigated computationally and experimentally. The truncated tail phospholipids, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC), are two major oxidation products of the unsaturated phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine. A combination of coarse-grained molecular dynamics simulations, Laurdan multiphoton imaging, and atomic force microscopy microindentation experiments was used to determine the impact of POVPC and PGPC on the structure of a multicomponent phospholipid bilayer and to assess the consequences of their incorporation on membrane packing and endothelial cell stiffness...
January 24, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28118079/sugar-and-spice-and-potassium-channel-modulation
#17
Irwin B Levitan
No abstract text is available yet for this article.
January 24, 2017: Channels
https://www.readbyqxmd.com/read/28078675/overexpression-of-a-diacylglycerol-acyltransferase-gene-in-phaeodactylum-tricornutum-directs-carbon-towards-lipid-biosynthesis
#18
Jorge Dinamarca, Orly Levitan, G Kenchappa Kumaraswamy, Desmond S Lun, Paul G Falkowski
Under nutrient deplete conditions, diatoms accumulate between 15% to 25% of their dry weight as lipids, primarily as triacylglycerols (TAGs). As in most eukaryotes, these organisms produce TAGs via the acyl-CoA dependent Kennedy pathway. The last step in this pathway is catalyzed by diacylglycerol acyltransferase (DGAT) that acylates diacylglycerol (DAG) to produce TAG. To test our hypothesis that DGAT plays a major role in controlling the flux of carbon towards lipids, we overexpressed a specific type II DGAT gene, DGAT2D, in the model diatom Phaeodactylum tricornutum...
January 12, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28073852/heat-maps-of-hypertension-diabetes-mellitus-and-smoking-in-the-continental-united-states
#19
Matthew Shane Loop, George Howard, Gustavo de Los Campos, Mohammad Z Al-Hamdan, Monika M Safford, Emily B Levitan, Leslie A McClure
BACKGROUND: Geographic variations in cardiovascular mortality are substantial, but descriptions of geographic variations in major cardiovascular risk factors have relied on data aggregated to counties. Herein, we provide the first description of geographic variation in the prevalence of hypertension, diabetes mellitus, and smoking within and across US counties. METHODS AND RESULTS: We conducted a cross-sectional analysis of baseline risk factor measurements and latitude/longitude of participant residence collected from 2003 to 2007 in the REGARDS study (Reasons for Geographic and Racial Differences in Stroke)...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28045797/quality-of-care-for-work-associated-carpal-tunnel-syndrome
#20
Teryl Nuckols, Craig Conlon, Michael Robbins, Michael Dworsky, Julie Lai, Carol P Roth, Barbara Levitan, Seth Seabury, Rachana Seelam, Steven M Asch
OBJECTIVE: To evaluate the quality of care provided to individuals with workers' compensation claims related to Carpal tunnel syndrome (CTS) and identify patient characteristics associated with receiving better care. METHODS: We recruited subjects with new claims for CTS from 30 occupational clinics affiliated with Kaiser Permanente Northern California. We applied 45 process-oriented quality measures to 477 subjects' medical records, and performed multivariate logistic regression to identify patient characteristics associated with quality...
January 2017: Journal of Occupational and Environmental Medicine
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