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https://www.readbyqxmd.com/read/28915854/medical-therapy-following-hospitalization-for-heart-failure-with-reduced-ejection-fraction-and-association-with-discharge-to-long-term-care-a-cross-sectional-analysis-of-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-population
#1
Emily B Levitan, Melissa K Van Dyke, Ligong Chen, Raegan W Durant, Todd M Brown, J David Rhodes, Olusola Olubowale, Oluwole Muyiwa Adegbala, Meredith L Kilgore, Justin Blackburn, Karen C Albright, Monika M Safford
BACKGROUND: Less intensive treatment for heart failure with reduced ejection fraction (HFrEF) may be appropriate for patients in long-term care settings because of limited life expectancy, frailty, comorbidities, and emphasis on quality of life. METHODS: We compared treatment patterns between REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants discharged to long-term care versus home following HFrEF hospitalizations. We examined medical records and Medicare pharmacy claims for 147 HFrEF hospitalizations among 80 participants to obtain information about discharge disposition and medication prescriptions and fills...
September 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28890000/maternal-drd2-slc6a3-and-oxtr-genotypes-as-potential-moderators-of-the-relation-between-maternal-history-of-care-and-maternal-cortisol-secretion-in-the-context-of-mother-infant-separation
#2
Jaclyn A Ludmer, Brittany Jamieson, Andrea Gonzalez, Robert Levitan, James Kennedy, Vanessa Villani, Mario Masellis, Vincenzo S Basile, Leslie Atkinson
A mother's cortisol secretion is importantly associated with her own mental health and her infant's cortisol secretion. This study investigated the influences of maternal history of care and maternal DRD2, SLC6A3, and OXTR genotypes on maternal cortisol in the context of infant stress. A community sample of 296 mother-infant dyads completed a maternal separation at infant age 17 months. Maternal salivary cortisol, buccal cells, and self-reported history of care were collected. Multilevel models revealed that history of care had a greater influence on maternal baseline cortisol (but not cortisol trajectory) for mothers with more plasticity alleles of SLC6A3 (10R) and OXTR (G), relative to mothers with fewer or no plasticity alleles...
September 7, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28875370/how-prepared-are-pharmacists-to-support-atrial-fibrillation-patients-in-adhering-to-newly-prescribed-oral-anticoagulants
#3
Nadya Hamedi, Filipa Alves da Costa, Robert Horne, Michael Levitan, Amanda Begley, Sotiris Antoniou
Background The New Medicines Service (NMS) was implemented in the United Kingdom in 2011 and first evaluated in 2014, showing 10% increase on adherence. Objective To assess community pharmacists' current practice, knowledge and confidence in supporting patients' adherence as part of the NMS for patients on Oral Anti-Coagulants (OACs) for stroke prevention in Atrial Fibrillation. Setting Community pharmacists in London. Method An online cross-sectional survey was sent to pharmacists from their Local Pharmaceutical Committees and advertised by the Royal Pharmaceutical Society...
September 5, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28863824/preface
#4
EDITORIAL
Irena Levitan
No abstract text is available yet for this article.
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28863819/differential-effects-of-sterols-on-ion-channels-stereospecific-binding-vs-stereospecific-response
#5
Nicolas Barbera, Manuela A A Ayee, Belinda S Akpa, Irena Levitan
Numerous ion channels have been shown to be regulated by the level of membrane cholesterol, but the mechanisms responsible for these effects are still not well understood. The key question in the field is how to discriminate between the contributions of the two central mechanisms that might be responsible for the sensitivity of ion channels to cholesterol: specific sterol-protein interactions or regulation of channels by the bilayer physical properties. Comparative analysis of cholesterol and its isomers on the function of an ion channel is a powerful tool to achieve this goal...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28831745/the-ball-is-in-your-court-agenda-for-research-to-advance-the-science-of-patient-preferences-in-the-regulatory-review-of-medical-devices%C3%A2-in-the-united-states
#6
EDITORIAL
Bennett Levitan, A Brett Hauber, Marina G Damiano, Ross Jaffe, Stephanie Christopher
No abstract text is available yet for this article.
August 22, 2017: Patient
https://www.readbyqxmd.com/read/28827895/the-drosophila-foraging-gene-human-orthologue-prkg1-predicts-individual-differences-in-the-effects-of-early-adversity-on-maternal-sensitivity
#7
H Moriah Sokolowski, Oscar E Vasquez, Eva Unternaehrer, Dustin J Sokolowski, Stephanie D Biergans, Leslie Atkinson, Andrea Gonzalez, Patricia P Silveira, Robert Levitan, Kieran J O'Donnell, Meir Steiner, James Kennedy, Michael J Meaney, Alison S Fleming, Marla B Sokolowski
There is variation in the extent to which childhood adverse experience affects adult individual differences in maternal behavior. Genetic variation in the animal foraging gene, which encodes a cGMP-dependent protein kinase, contributes to variation in the responses of adult fruit flies, Drosophila melanogaster, to early life adversity and is also known to play a role in maternal behavior in social insects. Here we investigate genetic variation in the human foraging gene (PRKG1) as a predictor of individual differences in the effects of early adversity on maternal behavior in two cohorts...
April 2017: Cognitive Development
https://www.readbyqxmd.com/read/28810419/body-image-and-dissatisfaction-among-rural-deep-south-african-american-women-in-a-weight-loss-intervention
#8
Erica R Johnson, Olivia Affuso, Emily B Levitan, Tiffany L Carson, Monica L Baskin
Body image perception may impact health-promoting behaviors as well as knowledge regarding health risks associated with obesity. Our cross-sectional analysis evaluated body image and its association with body mass index among overweight and obese treatment-seeking African American women ( N = 409). Differences between current and desired body image were captured using the Pulvers scale. Results indicated the presence of body image dissatisfaction among participants (median = 2.00, interquartile range: 2...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803562/dopamine-receptor-d2-drd2-dopamine-transporter-solute-carrier-family-c6-member-4-slc6a3-and-catechol-o-methyltransferase-comt-genes-as-moderators-of-the-relation-between-maternal-history-of-maltreatment-and-infant-emotion-regulation
#9
Vanessa Villani, Jaclyn Ludmer, Andrea Gonzalez, Robert Levitan, James Kennedy, Mario Masellis, Vincenzo S Basile, Christine Wekerle, Leslie Atkinson
Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28768753/pcsk9-loss-of-function-variants-low-density-lipoprotein-cholesterol-and-risk-of-coronary-heart-disease-and-stroke-data-from-9-studies-of-blacks-and-whites
#10
Shia T Kent, Robert S Rosenson, Christy L Avery, Yii-Der I Chen, Adolfo Correa, Steven R Cummings, L Adrienne Cupples, Mary Cushman, Daniel S Evans, Vilmundur Gudnason, Tamara B Harris, George Howard, Marguerite R Irvin, Suzanne E Judd, J Wouter Jukema, Leslie Lange, Emily B Levitan, Xiaohui Li, Yongmei Liu, Wendy S Post, Iris Postmus, Bruce M Psaty, Jerome I Rotter, Monika M Safford, Colleen M Sitlani, Albert V Smith, James D Stewart, Stella Trompet, Fangui Sun, Ramachandran S Vasan, J Michael Woolley, Eric A Whitsel, Kerri L Wiggins, James G Wilson, Paul Muntner
BACKGROUND: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. METHODS AND RESULTS: These 9 studies together included 17 459 blacks with 403 (2...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28767927/mindfulness-in-mood-and-anxiety-disorders-a-review-of-the-literature
#11
Michele F Rodrigues, Antonio E Nardi, Michelle Levitan
Introduction: The objective of this study was to conduct a review of the literature covering the use of different mindfulness-based therapy approaches in treatment of mood and anxiety disorders, including mindfulness skills and mindfulness linked to emotional regulation and fear of negative appraisal. Methods: A review was conducted of literature identified by searching the scientific databases PubMed and PsycINFO with the following keywords: mindfulness, mood disorders, and anxiety disorders...
July 31, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28701359/oxldl-induced-endothelial-proliferation-via-rho-rock-akt-p27-kip1-signaling-prevention-by-cholesterol-loading
#12
Chongxu Zhang, Crystal Adamos, Myung-Jin Oh, Jugajyoti Baruah, Manuela A A Ayee, Dolly Mehta, Kishore K Wary, Irena Levitan
Oxidized modifications of LDL (oxLDL) are known to play a major role in endothelial dysfunction and the development of atherosclerosis. In this study, we provide comparative analysis of the effects of two major types of oxLDL, copper oxidized LDL (Cu(2+)-oxLDL) and Lipoxygenase oxidized LDL (LPO-oxLDL) on proliferation of Human Aortic Endothelial Cells (HAECs). We show that Cu(2+)-oxLDL enhances HAECs proliferation in a dose and oxidation-dependent manner. Similarly, LPO-oxLDL also has a positive effect on HAECs proliferation...
July 12, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28696265/black-white-differences-in-incident-fatal-nonfatal-and-total-coronary-heart-disease
#13
COMPARATIVE STUDY
Lisandro D Colantonio, Christopher M Gamboa, Joshua S Richman, Emily B Levitan, Elsayed Z Soliman, George Howard, Monika M Safford
BACKGROUND: Blacks have higher coronary heart disease (CHD) mortality compared with whites. However, a previous study suggests that nonfatal CHD risk may be lower for black versus white men. METHODS: We compared fatal and nonfatal CHD incidence and CHD case-fatality among blacks and whites in the Atherosclerosis Risk in Communities study (ARIC), the Cardiovascular Health Study (CHS), and the Reasons for Geographic and Racial Differences in Stroke study (REGARDS) by sex...
July 11, 2017: Circulation
https://www.readbyqxmd.com/read/28630968/designing-self-powered-materials-systems-that-perform-pattern-recognition
#14
Yan Fang, Victor V Yashin, Steven P Levitan, Anna C Balazs
Inspired by the advances in both materials and computer science, we describe efforts to design "materials that compute" where the material and the computer are the same entity. Using theory and simulation, we devise systems that integrate the behavior of self-oscillating gels and fundamental concepts from oscillator-based computing. We specifically focus on gels that undergo the Belousov-Zhabotinsky (BZ) reaction and thus exhibit self-sustained oscillations. In our models, we couple the BZ gel to an overlaying piezoelectric (PZ) cantilever to create a BZ-PZ unit...
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28621991/new-approaches-to-coding-information-using-inverse-scattering-transform
#15
L L Frumin, A A Gelash, S K Turitsyn
Remarkable mathematical properties of the integrable nonlinear Schrödinger equation (NLSE) can offer advanced solutions for the mitigation of nonlinear signal distortions in optical fiber links. Fundamental optical soliton, continuous, and discrete eigenvalues of the nonlinear spectrum have already been considered for the transmission of information in fiber-optic channels. Here, we propose to apply signal modulation to the kernel of the Gelfand-Levitan-Marchenko equations that offers the advantage of a relatively simple decoder design...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28605807/visual-sensory-and-visual-cognitive-function-and-rate-of-crash-and-near-crash-involvement-among-older-drivers-using-naturalistic-driving-data
#16
MULTICENTER STUDY
Carrie Huisingh, Emily B Levitan, Marguerite R Irvin, Paul MacLennan, Virginia Wadley, Cynthia Owsley
Purpose: An innovative methodology using naturalistic driving data was used to examine the association between visual sensory and visual-cognitive function and rates of future crash or near-crash involvement among older drivers. Methods: The Strategic Highway Research Program (SHRP2) Naturalistic Driving Study was used for this prospective analysis. The sample consisted of N = 659 drivers aged ≥70 years and study participation lasted 1 or 2 years for most participants...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28600320/limited-distal-organelles-and-synaptic-function-in-extensive-monoaminergic-innervation
#17
Juan Tao, Dinara Bulgari, David L Deitcher, Edwin S Levitan
Organelles such as neuropeptide-containing dense-core vesicles (DCVs) and mitochondria travel down axons to supply synaptic boutons. DCV distribution among en passant boutons in small axonal arbors is mediated by circulation with bidirectional capture. However, it is not known how organelles are distributed in extensive arbors associated with mammalian dopamine neuron vulnerability, and with volume transmission and neuromodulation by monoamines and neuropeptides. Therefore, we studied presynaptic organelle distribution in Drosophila octopamine neurons that innervate ∼20 muscles with ∼1500 boutons...
August 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28521765/inhibition-of-o-glcnacase-leads-to-elevation-of-o-glcnac-tau-and-reduction-of-tauopathy-and-cerebrospinal-fluid-tau-in-rtg4510-mice
#18
Nicholas B Hastings, Xiaohai Wang, Lixin Song, Brent D Butts, Diane Grotz, Richard Hargreaves, J Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J McEachern, Xuesong Ouyang, Thomas W Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J Vocadlo, Ganfeng Wang, Joseph L Duffy, Eric M Parker, Lili Zhang
BACKGROUND: Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modification of tau that involves the addition of N-acetylglucosamine onto serine and threonine residues. Inhibition of O-GlcNAcase (OGA), the enzyme responsible for the removal of O-GlcNAc modification, has been shown to reduce tau pathology in several transgenic models...
May 18, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28492415/anticoagulation-control-in-patients-with-ventricular-assist-devices
#19
Amelia K Boehme, Salpy V Pamboukian, James F George, T Mark Beasley, James K Kirklin, Jose Tallaj, Chrisly Dillon, Emily B Levitan, Russell Griffin, Gerald McGwin, William B Hillegass, Nita A Limdi
Anticoagulation control has been associated with risk of thromboembolism and hemorrhage. Herein, we explore the relationship between anticoagulation control achieved in left ventricular assist device (LVAD) patients and evaluate the association with risk of thromboembolism and hemorrhage. Patients (19 years old or older) with a continuous flow LVAD placed from 2006 to 2012. Proportion of time spent in target range (PTTR) for international normalized ratio (INR) was estimated with target range of 2.0-3.0. Proportion of time spent in target range was categorized into PTTR > 60%, PTTR ≥ 50 < 60%, and PTTR < 50%...
May 9, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28487663/binge-eating-disorder-bed-in-relation-to-addictive-behaviors-and-personality-risk-factors
#20
Caroline Davis, Laura Mackew, Robert D Levitan, Allan S Kaplan, Jacqueline C Carter, James L Kennedy
While there is good evidence that binge eating disorder (BED) is linked to higher-than-expected use of a broad range of addictive behaviors, mechanisms underlying this association are not well understood. Using a mediation-analytical approach with three age- and gender-matched groups - overweight/obese adults with (n = 42) and without (n = 104) BED, and normal-weight control participants (n = 73) - we tested the hypothesis that adults with BED would engage in more addictive behaviors and have higher scores on a personality-risk index than the two control groups...
2017: Frontiers in Psychology
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