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David Levitan, Yaihara Fortis-Santiago, Joshua A Figueroa, Emily E Reid, Takashi Yoshida, Nicholas C Barry, Abigail Russo, Donald B Katz
: In neuroscientists' attempts to understand the long-term storage of memory, topics of particular importance and interest are the cellular and system mechanisms of maintenance (e.g., those sensitive to ζ-inhibitory peptide, ZIP) and those induced by memory retrieval (i.e., reconsolidation). Much is known about each of these processes in isolation, but less is known concerning how they interact. It is known that ZIP sensitivity and memory retrieval share at least some molecular targets (e...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Robert D Levitan, Pauline Jansen, Barbara Wendland, Henning Tiemeier, Vincent W Jaddoe, Patricia P Silveira, James L Kennedy, Leslie Atkinson, Alison Fleming, Marla Sokolowski, Helene Gaudreau, Meir Steiner, Laurette Dubé, Jill Hamilton, Ellen Moss, Ashley Wazana, Michael Meaney
BACKGROUND: Recent evidence suggests that early exposure to low maternal sensitivity is a risk factor for obesity in children and adolescents. A separate line of study shows that the seven-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) increases susceptibility to environmental factors including maternal sensitivity. The current study integrates these lines of work by examining whether preschoolers carrying the 7R allele are more vulnerable to low maternal sensitivity as it relates to overweight/obesity risk...
October 11, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Craig Conlon, Steven Asch, Mark Hanson, Andrew Avins, Barbara Levitan, Carol Roth, Michael Robbins, Michael Dworsky, Seth Seabury, Teryl Nuckols
CONTEXT: Little is known about quality of care for occupational health disorders, although it may affect worker health and workers' compensation costs. Carpal tunnel syndrome (CTS) is a common work-associated condition that causes substantial disability. OBJECTIVE: To describe the design of a study that is assessing quality of care for work-associated CTS and associations with clinical outcomes and costs. DESIGN: Prospective observational study of 477 individuals with new workers' compensation claims for CTS without acute trauma who were treated at 30 occupational health clinics from 2011 to 2013 and followed for 18 months...
October 3, 2016: Permanente Journal
David Levitan, Shunit Gal-Ben-Ari, Christopher Heise, Tali Rosenberg, Alina Elkobi, Sharon Inberg, Carlo Sala, Kobi Rosenblum
The current dogma suggests that the formation of long-term memory (LTM) is dependent on protein synthesis but persistence of the memory trace is not. However, many of the studies examining the effect of protein synthesis inhibitors (PSIs) on LTM persistence were performed in the hippocampus, which is known to have a time-dependent role in memory storage, rather than the cortex, which is considered to be the main structure to store long-term memories. Here we studied the effect of PSIs on LTM formation and persistence in male Wistar Hola (n ≥ 5) rats by infusing the protein synthesis inhibitor, anisomycin (100 μg, 1 μl), into the gustatory cortex (GC) during LTM formation and persistence in conditioned taste aversion (CTA)...
2016: NPJ Sci Learn
Martin Ho, Anindita Saha, K Kimberly McCleary, Bennett Levitan, Stephanie Christopher, Kristen Zandlo, R Scott Braithwaite, A Brett Hauber
BACKGROUND: In response to 2012 guidance in which the US Food and Drug Administration's (FDA) Center for Devices and Radiological Health (CDRH) stated the importance of patient-centric measures in regulatory benefit-risk assessments, the Medical Device Innovation Consortium (MDIC) initiated a project. The project was used to develop a framework to help the Food and Drug Administration (FDA) and industry sponsors understand how patient preferences regarding benefit and risk might be integrated into the review of innovative medical devices...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Bettina Meiser, Michelle Peate, Charlene Levitan, Philip B Mitchell, Lyndal Trevena, Kristine Barlow-Stewart, Timothy Dobbins, Helen Christensen, Kerry A Sherman, Kate Dunlop, Peter R Schofield
We developed and pilot-tested the first online psycho-educational intervention that specifically targets people with a family history of depression ('LINKS'). LINKS provides genetic risk information and evidence-rated information on preventive strategies for depression and incorporates a risk assessment tool and several videos using professional actors. LINKS was pilot-tested in the general practitioner (GP) setting. The patient sample included people with a family history of at least one first-degree relative (FDR) with major depressive disorder (MDD) or bipolar disorder (BD)...
September 29, 2016: Journal of Genetic Counseling
Fenglong Xie, Lisandro D Colantonio, Jeffrey R Curtis, Monika M Safford, Emily B Levitan, George Howard, Paul Muntner
We described the linkage of primary data with administrative claims using the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study and Medicare. REGARDS study data were linked with Medicare claims by use of Social Security numbers. We compared REGARDS participants by Medicare linkage status, having fee-for-service (FFS) coverage or not, and with a 5% sample of Medicare beneficiaries who had FFS coverage in 2005, overall, by age (45-64 and ≥65 years), and by race. Among REGARDS participants who were ≥65 years of age, 80% had data linked to Medicare on their study-visit date (64% with FFS coverage)...
October 1, 2016: American Journal of Epidemiology
Yan Fang, Victor V Yashin, Steven P Levitan, Anna C Balazs
Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to perform a computational task in a self-organized manner, without the need for external electrical power sources. Each unit in this system integrates a self-oscillating gel, which undergoes the Belousov-Zhabotinsky (BZ) reaction, with an overlaying piezoelectric (PZ) cantilever...
September 2016: Science Advances
Kavitha Rao, Michelle C Stone, Alexis T Weiner, Kyle W Gheres, Chaoming Zhou, David L Deitcher, Edwin S Levitan, Melissa M Rolls
Mutations in over 50 genes including spastin and atlastin lead to Hereditary Spastic Paraplegia (HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon regeneration in a Drosophila model. Axon regeneration was similarly impaired in neurons when HSP proteins atlastin, seipin and spichthyin were reduced. Impaired regeneration was dependent on genetic background, and was observed when partial reduction of HSP proteins was combined with expression of dominant-negative microtubule regulators, suggesting HSP proteins work with microtubules to promote regeneration...
September 7, 2016: Molecular Biology of the Cell
Emily B Levitan, Laura A Graham, Javier A Valle, Joshua S Richman, Robert Hollis, Carla N Holcomb, Thomas M Maddox, Mary T Hawn
BACKGROUND: Echocardiography is not recommended for routine pre-surgical evaluation but may have value for patients at high risk of major adverse cardiovascular events (MACE). The objective of this study was to evaluate whether pre-operative echocardiography is associated with lower risk of post-operative MACE among patients with coronary artery disease. METHODS: Using administrative and registry data, we examined associations of echocardiography within 3 months prior to surgery with postoperative MACE (myocardial infarction, revascularization, or death within 30 days) among patients with coronary artery disease undergoing elective, non-cardiac surgeries in the United States Veterans Affairs healthcare system in 2000-2012...
2016: BMC Cardiovascular Disorders
Deborah Chinn, Tony Levitan, Trevor Murrells
Many people with intellectual disabilities rely on social care provision, though little research has looked at how access to such provision is distributed nationally. Evidence from children's services suggests that there are large discrepancies between local authorities (LAs) in terms of the resources expended on interventions with children and families, which can be explained by variations linked to geographical location, namely the level of socioeconomic deprivation between LAs, constituting 'child welfare inequalities'...
September 4, 2016: Health & Social Care in the Community
Kristal R Tucker, Samantha L Cavolo, Edwin S Levitan
Pyridine nucleotides are redox coenzymes that are critical in bioenergetics, metabolism and neurodegeneration. Here brain slice multiphoton microscopy shows that substantia nigra dopamine neurons, which are sensitive to stress in mitochondria and the endoplasmic reticululm (ER), display elevated combined NADH (reduced nicotinamide adenine dinucleotide) and NADPH (reduced nicotinamide adenine dinucleotide phosphate) (i.e., NAD(P)H) autofluorescence. Despite limited mitochondrial mass, organellar NAD(P)H is extensive because much of the signal is derived from ER...
August 31, 2016: Molecular Biology of the Cell
A E Tyrer, R D Levitan, S Houle, A A Wilson, J N Nobrega, P M Rusjan, J H Meyer
OBJECTIVE: To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) during winter in seasonal affective disorder (SAD). 5-HTT BPND fluctuates seasonally to a greater extent in SAD relative to health. We hypothesized that in SAD, 5-HTT BPND would be reduced in the ACC and PFC following light therapy. METHODS: Eleven SAD participants underwent [(11) C] DASB positron emission tomography (PET) scans to measure 5-HTT BPND before and after 2 weeks of daily morning light therapy...
November 2016: Acta Psychiatrica Scandinavica
Anna L Campbell, Don R Levitan, David J Hosken, Ceri Lewis
Sperm competition is extremely common in many ecologically important marine taxa. Ocean acidification (OA) is driving rapid changes to the marine environments in which freely spawned sperm operate, yet the consequences of OA on sperm performance are poorly understood in the context of sperm competition. Here, we investigated the impacts of OA (+1000 μatm pCO2) on sperm competitiveness for the sea urchin Paracentrotus lividus. Males with faster sperm had greater competitive fertilisation success in both seawater conditions...
2016: Scientific Reports
Swaty Arora, Daniel Levitan, Narottam Regmi, Gurinder Sidhu, Raavi Gupta, Anthony D Nicastri, Subodh J Saggi, Albert Braverman
The incidence of glomerulonephritis, as a manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has always been considered low. Though renal infiltration is usually detected at post-mortem, it does not often interfere with kidney function [1]. Though immunoglobulin (Ig) levels in most CLL patients are subnormal, small monoclonal Ig peaks are occasionally detected in serum. They were present in a number of reported CLL nephropathy patients, and not all were cryoglobulins; serum and glomerular staining were concordant for Ig type [2,3,4]...
September 2016: Blood Cells, Molecules & Diseases
Emily B Levitan, Ali Ahmed, Donna K Arnett, Joseph F Polak, W Gregory Hundley, David A Bluemke, Susan R Heckbert, David R Jacobs, Jennifer A Nettleton
BACKGROUND: Data are limited on the relation between dietary patterns and left ventricular (LV) structure and function. OBJECTIVE: We examined cross-sectional associations of a diet-score assessment of a Mediterranean dietary pattern with LV mass, volume, mass-to-volume ratio, stroke volume, and ejection fraction. DESIGN: We measured LV variables with the use of cardiac MRI in 4497 participants in the Multi-Ethnic Study of Atherosclerosis study who were aged 45-84 y and without clinical cardiovascular disease...
September 2016: American Journal of Clinical Nutrition
Vasanth Coorg, Rachel D Levitan, Richard D Gerkin, Jared Muenzer, Anne-Michelle Ruha
INTRODUCTION: Scorpion envenomation is potentially life-threatening and affects children in the Southwestern USA. An FDA-approved antivenom is available, but its high cost has led to use of off-label antivenom dosing or supportive care alone as alternatives to FDA-recommended dosing. This study sought to determine whether treatment approach influences outcomes in envenomated children. METHODS: A retrospective cohort study of children with grade III or IV scorpion envenomation evaluated in Phoenix Children's Hospital ED between September 1, 2011, and March 31, 2014...
August 3, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Bennett Levitan, Michael Markowitz, Ibrahim Turkoz, Dong-Jing Fu, Srihari Gopal, Larry Alphs
The purpose of this study was to conduct a post-hoc benefit-risk assessment of paliperidone palmitate once-monthly (PP1M) injectable versus oral paliperidone extended-release (ER) in schizophrenia maintenance treatment. The Benefit-Risk Action Team framework was used to structure the analysis based on patient-level data from two similar, double-blind, placebo-controlled relapse studies. Efficacy outcomes were relapse, psychiatric hospitalization, Clinical Global Impression-Severity scale, Personal and Social Performance (PSP) scale, and Positive and Negative Syndrome Scale (PANSS)...
November 2016: International Clinical Psychopharmacology
Cathryn Gordon Green, Vanessa Babineau, Alexia Jolicoeur-Martineau, Andrée-Anne Bouvette-Turcot, Klaus Minde, Roberto Sassi, Martin St-André, Normand Carrey, Leslie Atkinson, James L Kennedy, Meir Steiner, John Lydon, Helene Gaudreau, Jacob A Burack, Robert Levitan, Michael J Meaney, Ashley Wazana
Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother-infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs...
July 18, 2016: Development and Psychopathology
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