keyword
https://read.qxmd.com/read/38484495/whole-exome-sequencing-of-placental-chorangioma
#21
JOURNAL ARTICLE
Rachelle P Mendoza, Kristina Doytcheva, Minhaz Ud Dean, Kyla M Jorgenson, Donghyuk Choi, Jeremy Segal, Peng Wang, Ricardo R Lastra
INTRODUCTION: Placental chorangioma is a benign non-trophoblastic vascular proliferation of the placental chorion favored to represent hamartoma-like or hyperplastic capillary lesions. As the exact pathophysiology has not been established, we investigated the molecular characteristics of placental chorangiomas using exploratory whole exome sequencing. METHODS: Three cases were retrospectively selected and whole exome sequencing was performed on macrodissected lesions...
March 8, 2024: Placenta
https://read.qxmd.com/read/38484249/uncovering-surface-penetration-by-enterococci-from-urinary-tract-infection-patients
#22
JOURNAL ARTICLE
Stephanie Sansone, Yusibeska Ramos, Saya Segal, Tirsit S Asfaw, Diana K Morales
IMPORTANCE: The relationship between Enterococcus faecalis vaginal colonization and urinary tract infections (UTIs) remains uncertain. OBJECTIVE: We aimed to evaluate the surface invasion capability of E faecalis isolates from patients with and without UTIs as a potential readout of pathogenicity. STUDY DESIGN: Participants were females from urogynecology clinics, comprising symptomatic UTI and asymptomatic non-UTI patients, categorized by the presence or absence of E faecalis-positive cultures identified via standard urine culture techniques...
March 1, 2024: Urogynecology (Phila)
https://read.qxmd.com/read/38482249/immune-checkpoint-blockade-induced-sarcoid-like-reaction-mimicking-progression-of-disease-in-a-patient-with-microsatellite-instable-colorectal-cancer-case-report-and-review-of-the-literature
#23
Fergus Keane, Elizabeth Yogiaveetil, Brie Kezlarian, Maria Lagratta, Neil H Segal, Ghassan Abou-Alfa, Eileen M O'Reilly, Leonard Saltz, Imane El Dika
BACKGROUND: Oncologists are prescribing checkpoint inhibitors with greater frequency, and an awareness of and ability to recognize immune-related adverse events (irAEs) is a key part of the safe administration of these drugs. CASE DESCRIPTION: Herein, we report the case of a 26-year-old male diagnosed with de novo metastatic right-sided colon cancer to the liver, with tumor immunohistochemistry demonstrating loss of MSH2 and MSH6 , and a pathogenic mutation in MSH2 identified on germline testing, consistent with Lynch Syndrome...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38467878/author-correction-the-type-ii-raf-inhibitor-tovorafenib-in-relapsed-refractory-pediatric-low-grade-glioma-the-phase-2-firefly-1-trial
#24
Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J Waanders, David S Ziegler, Olaf Witt, Patricia A Baxter, Hyoung Jin Kang, Timothy E Hassall, Jung Woo Han, Darren Hargrave, Andrea T Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche, Cassie Kline, Mohamed S Abdelbaki, Nada Jabado, Nicholas G Gottardo, Nicolas U Gerber, Nicholas S Whipple, Devorah Segal, Susan N Chi, Liat Oren, Enrica E K Tan, Sabine Mueller, Izzy Cornelio, Lisa McLeod, Xin Zhao, Ashley Walter, Daniel Da Costa, Peter Manley, Samuel C Blackman, Roger J Packer, Karsten Nysom
No abstract text is available yet for this article.
March 11, 2024: Nature Medicine
https://read.qxmd.com/read/38467589/association-of-perioperative-transfusion-of-fresh-frozen-plasma-and-outcomes-after-cardiac-surgery
#25
JOURNAL ARTICLE
Jake V Hinton, Zhongyue Xing, Calvin Fletcher, Luke A Perry, Alexandra Karamesinis, Jenny Shi, Jahan C Penny-Dimri, Dhruvesh Ramson, Tim G Coulson, Reny Segal, Julian A Smith, Jenni Williams-Spence, Laurence Weinberg, Rinaldo Bellomo
BACKGROUND: Fresh frozen plasma (FFP) transfusion is used to manage coagulopathy and bleeding in cardiac surgery patients despite uncertainty about its safety and effectiveness. METHODS: We performed a propensity score matched analysis of the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database including patients from 39 centres from 2005 to 2018. We investigated the association of perioperative FFP transfusion with mortality and other clinical outcomes...
March 11, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38461944/incidence-of-blepharoptosis-following-intravitreal-anti-vascular-endothelial-growth-factor-injections
#26
JOURNAL ARTICLE
Andrew Y Lee, Kyle Kovacs, Anton Orlin, Szilard Kiss, Donald J D'Amico, Kira L Segal, Gary J Lelli, Kyle J Godfrey
PURPOSE: We aimed to determine the incidence of blepharoptosis following intravitreal anti-vascular endothelial growth factor (VEGF) injections and compare the rates of blepharoptosis between patients injected with an eyelid speculum and those injected without a speculum. DESIGN: Retrospective cohort study METHODS: International Classification of Diseases (ICD-10) was used to identify patients with exudative age-related macular degeneration (AMD) and those who developed ptosis following intravitreal injections...
March 8, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38460720/should-we-recommend-delaying-art-treatment-during-wildfires
#27
EDITORIAL
Thalia R Segal, Amy M Padula
No abstract text is available yet for this article.
March 7, 2024: Fertility and Sterility
https://read.qxmd.com/read/38458639/final-results-of-urelumab-an-anti-cd137-agonist-monoclonal-antibody-in-combination-with-cetuximab-or-nivolumab-in-patients-with-advanced-solid-tumors
#28
JOURNAL ARTICLE
Nikhil I Khushalani, Patrick A Ott, Robert L Ferris, Tina Cascone, Dirk Schadendorf, Dung T Le, Manish R Sharma, Fabrice Barlesi, William Sharfman, Jason J Luke, Ignacio Melero, Deanne Lathers, Jaclyn Neely, Satyendra Suryawanshi, Abanti Sanyal, James L Holloway, Rasika Suryawanshi, Scott Ely, Neil H Segal
BACKGROUND: Resistance to immune checkpoint inhibitors and targeted treatments for cancer is common; thus, novel immunotherapy agents are needed. Urelumab is a monoclonal antibody agonist that binds to CD137 receptors expressed on T cells. Here, we report two studies that evaluated urelumab in combination with cetuximab or nivolumab in patients with select, advanced solid tumors. METHODS: CA186-018: Patients with metastatic colorectal cancer or metastatic squamous cell carcinoma of the head and neck (SCCHN) were treated in a dose-evaluation phase with urelumab 0...
March 7, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38445545/mode-based-morphometry-a-multiscale-approach-to-mapping-human-neuroanatomy
#29
JOURNAL ARTICLE
Trang Cao, James C Pang, Ashlea Segal, Yu-Chi Chen, Kevin M Aquino, Michael Breakspear, Alex Fornito
Voxel-based morphometry (VBM) and surface-based morphometry (SBM) are two widely used neuroimaging techniques for investigating brain anatomy. These techniques rely on statistical inferences at individual points (voxels or vertices), clusters of points, or a priori regions-of-interest. They are powerful tools for describing brain anatomy, but offer little insights into the generative processes that shape a particular set of findings. Moreover, they are restricted to a single spatial resolution scale, precluding the opportunity to distinguish anatomical variations that are expressed across multiple scales...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38430493/perceptions-of-cheating-among-students-of-health-professions
#30
JOURNAL ARTICLE
Abby S Kazley, Christine Andresen, Angela Mund, Karen A Wager, Clint Blankenship, Rick Segal
For many decades, academic cheating has been prevalent across many institutions and majors. This problem has been exacerbated by new technology that has increased opportunities for students to access and use information dishonestly. There is fear amongst faculty that dishonesty in the academic world could negatively impact professionals in their future careers. The greater prevalence of cheating may be related to students misunderstanding what constitutes cheating. To better understand students' perceptions of cheating, a group of faculty surveyed students across 11 academic programs at a college of health professions using a slightly modified version of a validated tool via an online platform...
2024: Journal of Allied Health
https://read.qxmd.com/read/38423894/a-review-of-post-covid-syndrome-pathophysiology-clinical-presentation-and-management-in-children-and-young-people
#31
REVIEW
Rebecca Johnston, Samatha Sonnappa, Anne-Lise Goddings, Elizabeth Whittaker, Terry Y Segal
Post Covid Syndrome (PCS) is a complex multi-system disorder with a spectrum of presentations. Severity ranges from mild to very severe with variable duration of illness and recovery. This paper discusses the difficulties defining and describing PCS. We review the current understanding of PCS, epidemiology, and predisposing factors. We consider potential mechanisms including viral persistence, clotting dysfunction and immunity. We review presentation and diagnosis and finally consider management strategies including addressing symptom burden, rehabilitation, and novel therapies...
January 18, 2024: Paediatric Respiratory Reviews
https://read.qxmd.com/read/38420636/obstetric-and-early-neonatal-outcomes-following-second-and-third-covid-19-vaccination-in-pregnancy
#32
JOURNAL ARTICLE
Ravit Peretz-Machluf, Mayan Gilboa, Shiran Bookstein-Peretz, Omri Segal, Noam Regev, Raanan Meyer, Gili Regev-Yochay, Yoav Yinon, Shlomi Toussia-Cohen
BACKGROUND: Pregnant women are at higher risk for severe coronavirus disease 2019 (COVID-19). Since the release of the BNT162b2 messenger RNA vaccine (Pfizer/BioNTech), there has been accumulated data about the three vaccine doses. However, information regarding obstetric and neonatal outcomes of pregnant women vaccinated with the third (booster) vaccine is limited and primarily retrospective. OBJECTIVES: To evaluate the obstetric and early neonatal outcomes of pregnant women vaccinated during pregnancy with the COVID-19 booster vaccine compared to pregnant women vaccinated only by the first two doses...
January 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38416036/plitidepsin-as-an-immunomodulator-against-respiratory-viral-infections
#33
JOURNAL ARTICLE
Alejandro Losada, Nuria Izquierdo-Useros, Pablo Aviles, Júlia Vergara-Alert, Irene Latino, Joaquim Segalés, Santiago F Gonzalez, Carmen Cuevas, Dàlia Raïch-Regué, María J Muñoz-Alonso, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Jordi Rodon, Lauren A Chang, Prajakta Warang, Gagandeep Singh, Marco Brustolin, Guillermo Cantero, Núria Roca, Mònica Pérez, Eugenio Bustos-Morán, Kris White, Michael Schotsaert, Adolfo García-Sastre
Plitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the effect of plitidepsin in IL-6 secretion in different in vitro and in vivo experimental models was studied. A strong plitidepsin-mediated reduction of IL-6 was found in human monocyte-derived macrophages exposed to nonproductive SARS-CoV-2. In resiquimod (a ligand of TLR7/8)-stimulated THP1 human monocytes, plitidepsin-mediated reductions of IL-6 mRNA and IL-6 levels were also noticed...
February 28, 2024: Journal of Immunology
https://read.qxmd.com/read/38415641/the-complete-genome-of-vibrio-sp-16-unveils-two-circular-chromosomes-and-a-distinctive-46-kb-plasmid
#34
JOURNAL ARTICLE
Xiaofen Wu, Anca M Segall, Carmela Giglione, Thierry Meinnel
The entire 4.6-Mb genome of Vibrio sp. 16, encoding 4,270 genes, best matches with Vibrio rotiferianus . A 46-kb plasmid (pVDT1), alongside two circular chromosomes, showcases parAB / repB partition genes and three toxin/antitoxin systems potentially linked to phage infection.
February 28, 2024: Microbiology Resource Announcements
https://read.qxmd.com/read/38413645/immunisation-efficacy-of-a-stabilised-sars-cov-2-spike-glycoprotein-in-two-geriatric-animal-models
#35
JOURNAL ARTICLE
Carla Usai, Erola Ainsua-Enrich, Victor Urrea Gales, Edwards Pradenas, Cristina Lorca-Oró, Ferran Tarrés-Freixas, Núria Roca, Mónica Pérez, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Núria Pedreño-Lopez, Julieta Carabelli, Benjamin Trinité, Ester Ballana, Eva Riveira-Muñoz, Nuria Izquierdo-Useros, Bonaventura Clotet, Julià Blanco, Victor Guallar, Guillermo Cantero, Júlia Vergara-Alert, Jorge Carrillo, Joaquim Segalés
Age is associated with reduced efficacy of vaccines and linked to higher risk of severe COVID-19. Here we determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike glycoprotein (S-29) that had previously shown high efficacy in young animals. Thirteen to 18-month-old golden Syrian hamsters (GSH) and 22-23-month-old K18-hCAE2 mice were immunised twice with S-29 protein in AddaVaxTM adjuvant. GSH were intranasally inoculated with SARS-CoV-2 either two weeks or four months after the booster dose, while all K18-hACE2 mice were intranasally inoculated two weeks after the second immunisation...
February 27, 2024: NPJ Vaccines
https://read.qxmd.com/read/38397646/poverty-food-insecurity-nexus-in-the-post-construction-context-of-a-large-hydropower-dam-in-the-brazilian-amazon
#36
JOURNAL ARTICLE
Igor Cavallini Johansen, Miquéias Freitas Calvi, Verônica Gronau Luz, Ana Maria Segall-Corrêa, Caroline C Arantes, Victoria Judith Isaac, Renata Utsunomiya, Vanessa Cristine E Souza Reis, Emilio F Moran
Within the 2030 Sustainable Development Agenda, large hydropower dams are positioned as a sustainable energy source, notwithstanding their adverse impacts on societies and ecosystems. This study contributed to ongoing discussions about the persistence of critical social issues, even after the investments of large amounts of resources in areas impacted by the construction of large hydropower dams. Our study focused on food insecurity and evaluated this issue in the city of Altamira in the Brazilian Amazon, which has been profoundly socially and economically impacted by the construction, between 2011 and 2015, of Brazil's second-largest dam, namely, Belo Monte...
January 30, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38395414/branch-retinal-vein-occlusion-treated-with-anti-vegf-to-switch-or-not-to-switch
#37
JOURNAL ARTICLE
Reut Shor, Ori Segal, Dana Barequet, Eran Greenbaum, Omer Trivizki, Anat Loewenstein, Gilad Rabina
OBJECTIVE: To evaluate visual outcomes after switching from bevacizumab to ranibizumab or aflibercept in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO). DESIGN: A retrospective, multi-center, observational study. PARTICIPANTS: Patients diagnosed with BRVO and were treated with at least 3 bevacizumab injections, before anti VEGF switch. METHODS: The follow-up period was 36 months, and the primary study outcomes assessed changes in best corrected visual acuity (BCVA) after anti VEGF switch...
February 22, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38394254/listening-preference-for-child-directed-speech-versus-time-reversed-speech-in-moderate-preterm-infants-compared-to-full-term-infants
#38
JOURNAL ARTICLE
Osnat Segal, Dana Moyal
PURPOSE: The purpose of the present study was to examine whether there is a listening preference for child-directed speech (CDS) over backward speech in moderate-preterm infants (MPIs). METHOD: Eighteen MPIs of gestational age of 32.0 weeks (range: 32-34.06 weeks), chronological age of 8.09 months, and maturation age of 6.48 months served as the experimental group. The two control groups consisted of a total of 36 infants-20 full-term infants matched for chronological age and 16 full-term infants matched for maturation age...
February 23, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
https://read.qxmd.com/read/38389044/prfect-a-tool-to-predict-programmed-ribosomal-frameshifts-in-prokaryotic-and-viral-genomes
#39
JOURNAL ARTICLE
Katelyn McNair, Peter Salamon, Robert A Edwards, Anca M Segall
BACKGROUND: One of the stranger phenomena that can occur during gene translation is where, as a ribosome reads along the mRNA, various cellular and molecular properties contribute to stalling the ribosome on a slippery sequence and shifting the ribosome into one of the other two alternate reading frames. The alternate frame has different codons, so different amino acids are added to the peptide chain. More importantly, the original stop codon is no longer in-frame, so the ribosome can bypass the stop codon and continue to translate the codons past it...
February 22, 2024: BMC Bioinformatics
https://read.qxmd.com/read/38380982/partnership-with-the-university-of-s%C3%A3-o-paulo-panel-of-twins-a-four-city-tour-and-more-twin-research-reviews-twin-research-on-binge-eating-twins-physical-outcomes-linked-to-different-diets-working-conditions-and-sickness-absence-in-swedish-twins-facial-morphology
#40
JOURNAL ARTICLE
Nancy L Segal
This article begins with an overview of twin research in Brazil, initiated by the University of São Paulo Panel of Twins. I met with many new research collaborators and students while on a fall 2023 four-city lecture tour in that country. A meeting with a world-famous surgeon who recently separated craniopagus conjoined twin pairs is also described. This overview is followed by summaries of twin research on binge eating, twins' physical outcomes linked to different diets, working conditions and sickness absence in Swedish Twins and facial morphology differences in monozygotic twins...
February 21, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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