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https://www.readbyqxmd.com/read/29453822/full-genome-sequencing-of-porcine-circovirus-3-field-strains-from-denmark-italy-and-spain-demonstrates-a-high-within-europe-genetic-heterogeneity
#1
G Franzo, M Legnardi, C K Hjulsager, F Klaumann, L E Larsen, J Segales, M Drigo
Porcine circovirus 3 (PCV3) is a new species of the Circovirus genus, which has recently been associated with different clinical syndromes. Its presence has been reported in different countries of North and South America, Asia and recently also Europe (Poland). However, different from the other continents, no European PCV3 sequence is currently available in public databases. There is a strong need of epidemiological data and full-genome sequences from Europe because of its relevance in the understanding of PCV3 molecular epidemiology and control...
February 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29451318/effective-management-of-severe-cutaneous-mastocytosis-in-young-children-with-omalizumab-xolair-%C3%A2
#2
J D M Hughes, T Olynyc, H Chapdelaine, L Segal, B Miedzybrodzki, M Ben-Shoshan
Omalizumab (Xolair ® ) is an anti-IgE monoclonal antibody, which may benefit adults with systemic mastocytosis. We report effective treatment with omalizumab in two toddlers with severe diffuse cutaneous mastocytosis. Our cases offer preliminary evidence to support the safe use of omalizumab in paediatric patients with cutaneous mastocytosis.
February 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29444862/targeted-dna-demethylation-of-the-arabidopsis-genome-using-the-human-tet1-catalytic-domain
#3
Javier Gallego-Bartolomé, Jason Gardiner, Wanlu Liu, Ashot Papikian, Basudev Ghoshal, Hsuan Yu Kuo, Jenny Miao-Chi Zhao, David J Segal, Steven E Jacobsen
DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable epialleles. A well-characterized example of a stable epiallele in plants is fwa , which consists of the loss of DNA cytosine methylation (5mC) in the promoter of the FLOWERING WAGENINGEN ( FWA ) gene, causing up-regulation of FWA and a heritable late-flowering phenotype. Here we demonstrate that a fusion between the catalytic domain of the human demethylase TEN-ELEVEN TRANSLOCATION1 (TET1cd) and an artificial zinc finger (ZF) designed to target the FWA promoter can cause highly efficient targeted demethylation, FWA up-regulation, and a heritable late-flowering phenotype...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29433631/ampk-signaling-to-acetyl-coa-carboxylase-is-required-for-fasting-and-cold-induced-appetite-but-not-thermogenesis
#4
Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and promotes fatty acid oxidation by phosphorylation of acetyl-CoA carboxylase (ACC) 1 at Ser 79 and ACC2 at Ser 212 . Using mice with Ser 79 Ala/Ser 212 Ala knock-in mutations (ACC DKI) we find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure. At sub-thermoneutral temperatures, ACC DKI mice maintain normal energy expenditure and thermogenesis, but fail to increase appetite and lose weight...
February 13, 2018: ELife
https://www.readbyqxmd.com/read/29433603/is-distance-to-the-nearest-registered-public-automated-defibrillator-associated-with-the-probability-of-bystander-shock-for-victims-of-out-of-hospital-cardiac-arrest
#5
Joel Neves Briard, Luc de Montigny, Dave Ross, François de Champlain, Eli Segal
Introduction Rapid access to defibrillation is a key element in the management of out-of-hospital cardiac arrests (OHCAs). Public automated external defibrillators (PAEDs) are becoming increasingly available, but little information exists regarding the relation between the proximity to the arrest and their usage in urban areas. METHODS: This study is a retrospective, observational, cross-sectional analysis of non-traumatic OHCA during a 24-month period in the greater Montreal area (Quebec, Canada)...
February 13, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29424049/astrocyte-disruption-of-neurovascular-communication-is-linked-to-cortical-damage-in-an-animal-model-of-multiple-sclerosis
#6
Raya Eilam, Menahem Segal, Rafael Malach, Michael Sela, Ruth Arnon, Rina Aharoni
To elucidate mechanisms contributing to cortical pathology in multiple sclerosis (MS), we investigated neurovascular aberrations, in particular the association of astrocytes with cortical neurons and blood vessels, in mice induced with experimental autoimmune encephalomyelitis (EAE). Blood-brain barrier (BBB) dysfunction was evident by leakage of the tracer sodium fluorescein, along with reduced expression of claudin-5 by endothelial cells and desmin by pericytes. Immunohistological and ultrastructural analyses revealed detachment of the astroglial cell bodies from the blood vessels and loss of their connections with both the blood vessels and the neuronal synapses...
February 9, 2018: Glia
https://www.readbyqxmd.com/read/29415485/experimental-in-vivo-models-of-candidiasis
#7
REVIEW
Esther Segal, Michael Frenkel
Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus Candida. Candida infections are among the most common human mycoses. Candida species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. The mucosal-cutaneous forms-particularly vaginal infections-have a high prevalence. Vaginitis caused by Candida species is the second most common vaginal infection...
February 6, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29410437/unraveling-the-determinants-of-microrna-mediated-regulation-using-a-massively-parallel-reporter-assay
#8
Ilya Vainberg Slutskin, Shira Weingarten-Gabbay, Ronit Nir, Adina Weinberger, Eran Segal
Despite extensive research, the sequence features affecting microRNA-mediated regulation are not well understood, limiting our ability to predict gene expression levels in both native and synthetic sequences. Here we employed a massively parallel reporter assay to investigate the effect of over 14,000 rationally designed 3' UTR sequences on reporter construct repression. We found that multiple factors, including microRNA identity, hybridization energy, target accessibility, and target multiplicity, can be manipulated to achieve a predictable, up to 57-fold, change in protein repression...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29408600/title-impact-of-the-direct-transfer-to-percutaneous-coronary-intervention-capable-hospitals-on-survival-to-hospital-discharge-for-patients-with-out-of-hospital-cardiac-arrest
#9
Alexis Cournoyer, Éric Notebaert, Luc de Montigny, Dave Ross, Sylvie Cossette, Luc Londei-Leduc, Massimiliano Iseppon, Yoan Lamarche, Catalina Sokoloff, Brian J Potter, Alain Vadeboncoeur, Dominic Larose, Judy Morris, Raoul Daoust, Jean-Marc Chauny, Éric Piette, Jean Paquet, Yiorgos Alexandros Cavayas, François de Champlain, Eli Segal, Martin Albert, Marie-Claude Guertin, André Denault
AIMS: Patients suffering from out-of-hospital cardiac arrest (OHCA) are frequently transported to the closest hospital. Percutaneous coronary intervention (PCI) is often indicated following OHCA. This study's primary objective was to determine the association between being transported to a PCI-capable hospital and survival to discharge for patients with OHCA. The additional delay to hospital arrival which could offset a potential increase in survival associated with being transported to a PCI-capable center was also evaluated...
February 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29408538/lower-quadriceps-rate-of-force-development-is-associated-with-worsening-physical-function-in-adults-with-or-at-risk-for-knee-osteoarthritis-36-month-follow-up-data-from-the-osteoarthritis-initiative
#10
Bo Hu, Søren Thorgaard Skou, Barton L Wise, Glenn N Williams, Michael C Nevitt, Neil A Segal
OBJECTIVE: The purpose of this study was to determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance. DESIGN: Longitudinal cohort study SETTING: Community-based sample from 4 urban areas PARTICIPANTS: Osteoarthritis Initiative participants with or at risk for knee OA, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630)...
January 30, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29408027/comparison-of-cytokine-profiles-in-peripheral-blood-mononuclear-cells-between-piglets-born-from-porcine-circovirus-2-vaccinated-and-non-vaccinated-sows
#11
Salvador Oliver-Ferrando, Joaquim Segalés, Marina Sibila, Ivan Díaz
This study was aimed to evaluate the effect of Porcine circovirus 2 (PCV2) sow vaccination on cell-mediated immune responses in sows and their progeny. At 7 weeks before farrowing, fifteen PCV2 PCR negative pregnant sows with medium-low antibody values were selected and randomly distributed in two groups according to the antibody levels. Seven sows were vaccinated with a commercial PCV2 vaccine and eight were injected with phosphate-buffered saline at 6 and 3 weeks before farrowing. Blood samples were taken from sows and their piglets (n = 90) during the study duration...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29406779/at-the-root-defining-and-halting-progression-of-early-chronic-obstructive-pulmonary-disease
#12
Fernando J Martinez, MeiLan K Han, James P Allinson, R Graham Barr, Richard C Boucher, Peter Calverley, Bartolome R Celli, Stephanie A Christenson, Ronald G Crystal, Malin Fagerås, Christine M Freeman, Lars Groenke, Eric A Hoffman, Mehmet Kesimer, Konstantinos Kostikas, Robert Paine Iii, Shahin Rafii, Stephen I Rennard, Leopoldo N Segal, Renat Shaykhiev, Christopher Stevenson, Ruth Tal-Singer, Jørgen Vestbo, Prescott G Woodruff, Jeffrey L Curtis, Jadwiga A Wedzicha
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder with varying presentations and progression, but limited disease-modifying therapies. Trajectories of lung function decline in COPD differ significantly between individuals, with differences detectable in young adulthood. "Early disease" (initial manifestations in young individuals) should be distinguished from "late mild disease" (disease of mild severity in older individuals potentially present for decades). For research purposes, we propose an operational definition of early COPD: ever-smokers (≥10 pack-years) younger than 50 years with any of these abnormalities: (1) FEV1/FVC< lower limit of normal; (2) compatible CT abnormalities (airway abnormality and/or emphysema); or (3) FEV1 decline (≥60 mL/year)...
February 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29404741/the-risk-of-placenta-accreta-following-primary-cesarean-delivery
#13
Gil Zeevi, Dan Tirosh, Joel Baron, Maayan Yitshak Sade, Adi Segal, Reli Hershkovitz
OBJECTIVE: To (a) evaluate the risk for placenta accreta following primary cesarean section (CS), in regard to the stage of labor, the cesarean section was taken (elective prelabor vs. unplanned during labor); and (b) investigate whether the association between placenta accreta and maternal and neonatal complications is modified by the type of the primary CS. STUDY DESIGN: In a population-based retrospective cohort study, we included all singleton deliveries occurred in Soroka University Medical Center between 1991 and 2015, of women who had a history of a single CS...
February 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29398059/cesarean-delivery-and-childhood-malignancies-a-single-center-population-based-cohort-study
#14
Shirley Greenbaum, Eyal Sheiner, Tamar Wainstock, Idit Segal, Miriam Ben-Harush, Ruslan Sergienko, Asnat Walfisch
Rising rates of cesarean deliveries worldwide prompt the evaluation of long-term morbidity to the offspring. In this retrospective cohort study, we evaluated whether cesarean delivery influences the development of childhood malignancies. We identified an association of cesarean delivery with acute lymphoblastic leukemia in children, suggesting prudence in the recommendation of cesarean delivery for nonmedically indicated cases.
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29395514/from-dead-s-will-come-life
#15
EDITORIAL
Nicolas Segal
No abstract text is available yet for this article.
January 30, 2018: Resuscitation
https://www.readbyqxmd.com/read/29382396/higher-cut-off-serum-procalcitonin-level-for-sepsis-diagnosis-in-metastatic-solid-tumor-patients
#16
Segal Abdul Aziz, Erni Juwita Nelwan, Lugyanti Sukrisman, Suhendro Suhendro
OBJECTIVE: The current study aimed to know procalcitonin levels in patients with metastatic tumor, and to discover the cut-off point for sepsis in this population. A cross-sectional study was conducted with patients with solid tumor. Sepsis and systemic inflammation response syndrome (SIRS) were identified using clinical, laboratory, and microbiological criteria. The cut-off point was determined using receiver operating characteristic (ROC) curve. RESULTS: A total of 112 subjects enrolled in this study, 51% male, mean age 47...
January 30, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29378819/maize-transposable-elements-ac-ds-as-insertion-mutagenesis-tools-in-candida-albicans
#17
Kevin Mielich, Ella Shtifman-Segal, Julia C Golz, Guisheng Zeng, Yue Wang, Judith Berman, Reinhard Kunze
In non-model systems genetic research is often limited by the lack of techniques for the generation and identification of gene mutations. One approach to overcome this bottleneck is the application of transposons for gene tagging. We have established a two-element transposon tagging system, based on the transposable elements Activator (Ac)/Dissociation (Ds) from maize, for in vivo insertion mutagenesis in the fungal human pathogen Candidaalbicans A non-autonomous Ds transposon carrying a selectable marker was constructed into the ADE2 promoter on chromosome 3 and a codon usage-adapted Ac transposase gene was inserted into the neutral NEUT5L locus on chromosome 5...
January 29, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29369899/incidence-and-long-term-implications-of-prepouch-ileitis-an-observational-study
#18
Jonathan P Segal, Simon D McLaughlin, Omar D Faiz, Susan K Clark, Ailsa L Hart
BACKGROUND: Restorative proctocolectomy is the procedure of choice in patients with ulcerative colitis refractory to medical therapy. Prepouch ileitis is characterized by mucosal inflammation immediately proximal to the pouch. Prepouch ileitis is uncommon, and long-term follow-up data are lacking. OBJECTIVE: The aim of this study is to report the long-term outcomes of prepouch ileitis. DESIGN: We followed up a cohort of patients with prepouch ileitis that was originally described in 2009...
January 23, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29368537/superior-efficacy-and-improved-renal-and-bone-safety-after-switching-from-a-tenofovir-disoproxil-fumarate-tdf-to-a-tenofovir-alafenamide-taf-based-regimen-through-96-weeks-of-treatment
#19
Edwin DeJesus, Bernard Haas, Sorana Segal-Mauer, Moti Ramgopal, Anthony Mills, Nicolas Margot, Ya-Pei Liu, Tariro Makadzange, Scott McCallister
BACKGROUND: We previously demonstrated superior efficacy and safety advantages in HIV-infected, virologically suppressed adults switched to a regimen containing tenofovir alafenamide (TAF) as compared with those remaining on a tenofovir disoproxil fumarate (TDF) regimen through week 48. We now report longer-term data through week 96. METHODS: In this randomized, active-controlled, multicenter, open-label, non-inferiority trial (ClinicalTrials.gov number NCT01815736), we randomized virologically suppressed (HIV-1 RNA <50 copies/mL) adults (2:1) to receive a once-daily, single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (TAF group) or to continue one of four TDF-containing regimens (TDF group) for 96 weeks...
January 25, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29367361/twenty-years-of-biological-therapy-in-an-patient-with-ibd
#20
Wing Yan Mak, Jonathan P Segal, Ailsa Hart
This interesting case is the first to our knowledge to report outcomes of a patient with Crohn's disease (CD) treated with the biological drug, infliximab, for around 20 years. The case highlights the positive effect of long-term use of infliximab in achieving and maintaining remission in a patient with CD.In this case, loss of response to infliximab was not dependent on length of exposure to the drug. It also appeared that infliximab was still efficacious after drug holidays, which can be especially important around times of pregnancy...
January 23, 2018: BMJ Case Reports
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