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https://www.readbyqxmd.com/read/29031625/ideal-i-cpr-looking-beyond-shadows-in-a-cave
#1
Nicolas Segal, Scott Youngquist, Keith Lurie
Survival rates after cardiac arrest have shown minimal improvement in the last 60 years. However, in some forward-thinking institutions, out-of and in-hospital cardiac arrest survival rates exceed 20% and 40% respectively. These beacons can enlighten us, providing a clearer vision of what it takes to provide Ideal cardiopulmonary resuscitation. To make progress in a field that has seemingly stagnated for too many decades, we must be open to new ideas and develop bundles of care that work in communities with varying EMS systems and various existing infrastructure to bring the best practices to the rest of the country...
October 12, 2017: Resuscitation
https://www.readbyqxmd.com/read/29028437/stimulants-do-not-increase-the-risk-of-seizure-related-hospitalizations-in-children-with-epilepsy
#2
Xinyue Liu, Paul R Carney, Regina Bussing, Richard Segal, Linda B Cottler, Almut G Winterstein
OBJECTIVE: To evaluate the safety of stimulants in children with epilepsy. METHODS: In a retrospective cohort study based on Medicaid Analytic eXtract billing records from 26 U.S. states from 1999 to 2010, we identified incident stimulant use among children with epilepsy through outpatient encounter claims and pharmacy claims. We established a control group of nonusers and used frequency matching to generate index dates. We followed both cohorts for 12 months and calculated hazard ratios [HRs] of current and former use of stimulants versus no use on the outcome of seizure-related hospitalization using multivariate Cox proportional hazard models...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29025788/brief-mindfulness-meditation-for-depression-and-anxiety-symptoms-in-patients-undergoing-hemodialysis-a-pilot-feasibility-study
#3
Zoë Thomas, Marta Novak, Susanna Gabriela Torres Platas, Maryse Gautier, Angela Potes Holgin, Rebecca Fox, Marilyn Segal, Karl J Looper, Mark Lipman, Steven Selchen, Istvan Mucsi, Nathan Herrmann, Soham Rej
BACKGROUND AND OBJECTIVES: Up to 50% of patients undergoing hemodialysis suffer from symptoms of depression and/or anxiety. Access to traditional pharmacotherapies and psychotherapies for depression or anxiety in this patient population has been inadequate. The objective of this study was to investigate the feasibility and effectiveness of brief mindfulness meditation intervention for patients on hemodialysis with depression and anxiety symptoms. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was a randomized, controlled, assessor-blinded trial conducted in an urban hemodialysis unit...
October 12, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29025112/sodium-phosphate-enemas-do-not-worsen-renal-function-amongst-hospitalized-patients-with-mild-to-moderate-renal-failure-a-matched-case-control-study
#4
A Dagan, G Y Stein, S Winter, C Avaky, L Hofstetter, I Gringauz, A Biber, G Segal
Background: Sodium Phosphate enemas (SPEs) are widely used amongst hospitalized patients despite their potential to worsen renal failure. The extent to which this side effect is clinically relevant is questionable. Methods: We conducted a matched case-control, retrospective study in a cohort of hospitalized patients. Patients treated and untreated with SPEs were matched for age, gender, baseline creatinine, usage of certain medications and several background diagnoses...
August 16, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024661/paclitaxel-reduces-axonal-bclw-to-initiate-ip3r1-dependent-axon-degeneration
#5
Sarah E Pease-Raissi, Maria F Pazyra-Murphy, Yihang Li, Franziska Wachter, Yusuke Fukuda, Sara J Fenstermacher, Lauren A Barclay, Gregory H Bird, Loren D Walensky, Rosalind A Segal
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the molecular mechanisms of CIPN are not understood, and there are no available treatments. Here we show that the chemotherapeutic agent paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux, and activating calcium-dependent calpain proteases...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024067/evaluation-of-multiplex-real-time-pcr-for-identifying-dermatophytes-in-clinical-samples-a-multicentre-study
#6
Shany Sherman, Maya Goshen, Orit Treigerman, Keren Ben-Zion, Marie-Jeanne Carp, Noam Maisler, Inbal Binsky Ehrenreich, Aviva Kimchi, Sara Lifshitz, Gill Smollan, Batya Davidovici, Michael David, Emmilia Hodak, Rina Segal
BACKGROUND: The gold-standard method for dermatophyte identification involves direct microscopy and culture, which have inherent shortcomings. Only few molecular methods have been standardised for routine clinical work. OBJECTIVES: To develop and test a platform for identifying the most common dermatophytes in Israel using multiplex real-time polymerase chain reaction (RT-PCR). METHODS: Specific primers were designed for the multiplex system (LightCycler 480) according to known cultures and validated by reference isolates...
October 12, 2017: Mycoses
https://www.readbyqxmd.com/read/29017457/evaluation-of-a-pulsed-xenon-ultraviolet-disinfection-system-to-decrease-bacterial-contamination-in-operating-rooms
#7
Lynn El Haddad, Shashank S Ghantoji, Mark Stibich, Jason B Fleming, Cindy Segal, Kathy M Ware, Roy F Chemaly
BACKGROUND: Environmental cleanliness is one of the contributing factors for surgical site infections in the operating rooms (ORs). To decrease environmental contamination, pulsed xenon ultraviolet (PX-UV), an easy and safe no-touch disinfection system, is employed in several hospital environments. The positive effect of this technology on environmental decontamination has been observed in patient rooms and ORs during the end-of-day cleaning but so far, no study explored its feasibility between surgical cases in the OR...
October 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29016796/empowerment-of-athletes-with-cardiac-disorders-a-new-paradigm
#8
Rui Providencia, Carina Teixeira, Oliver R Segal, Augustus Ullstein, Kim Mueser, Pier D Lambiase
Athletes with cardiac disorders frequently pose an ethical and medical dilemma to physicians assessing their eligibility to participate in sport. In recent decades, patient empowerment has been gaining increasing recognition in clinical decision-making. Empowerment is a process through which people are involved over the decisions and actions that affect their own lives. In the context of a cardiac disorder, empowerment means giving an athlete the chance to participate in the decision about whether or not to remain active in competition...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28994159/calcium-and-electrical-dynamics-in-lymphatic-endothelium
#9
Erik J Behringer, Joshua P Scallan, Mohammad Jafarnejad, Jorge A Castorena-Gonzalez, Scott D Zawieja, James E Moore, Michael J Davis, Steven S Segal
Subsequent to a rise in intracellular Ca(2+) ([Ca(2+) ]i ), hyperpolarization of the endothelium coordinates vascular smooth muscle relaxation along resistance arteries during blood flow control. In the lymphatic vasculature, collecting vessels generate rapid contractions coordinated along lymphangions to propel lymph, but the underlying signalling pathways are unknown. We tested the hypothesis that lymphatic endothelial cells (LECs) exhibit Ca(2+) and electrical signalling properties that facilitate lymph propulsion...
October 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28992993/risk-prediction-model-for-in-hospital-mortality-in-women-with-st-elevation-myocardial-infarction-a-machine-learning-approach
#10
Hend Mansoor, Islam Y Elgendy, Richard Segal, Anthony A Bavry, Jiang Bian
BACKGROUND: Studies had shown that mortality due to ST-elevation myocardial infarction (STEMI) is higher in women compared with men. The purpose of this study is to develop and validate prediction models for all-cause in-hospital mortality in women admitted with STEMI using logistic regression and random forest, and to compare the performance and validity of the different models. METHODS: Data from the National Inpatient Sample (NIS) data years 2011-2013 were used to identify women admitted with STEMI...
October 6, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28992797/hydroxychloroquine-desensitization-an-effective-method-to-overcome-hypersensitivity-a-multicenter-experience
#11
Y Tal, R Maoz Segal, P Langevitz, S Kivity, Z Darnizki, N Agmon-Levin
Hydroxychloroquine (HCQ) is widely used to treat autoimmune/rheumatic diseases such as systemic lupus erythematosus (SLE). The immune modulation effects of HCQ have been highlighted as beneficial for maintaining remission of SLE as well as ameliorating skin, joint and other manifestations. Moreover, HCQ exposure for prolonged periods as well as during pregnancy is considered safe, therefore it is recommended for the vast majority of SLE patients. Although HCQ therapy requires follow-up by a specialist, its most common side effects are mild gastrointestinal disturbances, sensitivity to light and skin rashes...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28988786/omalizumab-for-severe-chronic-spontaneous-urticaria-real-life-experiences-of-280-patients
#12
Zahava Vadasz, Yuval Tal, Menachem Rotem, Vered Shichter-Confino, Keren Mahlab-Guri, Yael Graif, Aharon Kessel, Nancy Agmon-Levin, Ramit Maoz-Segal, Shmuel Kivity, Shira Benor, Idit Lachover-Roth, Yuri Zeldin, Migel Stein, Ori Toker, Gamal Hassoun, Shira Bezalel-Rosenberg, Elias Toubi, Ilan Asher, Zev Sthoeger
No abstract text is available yet for this article.
October 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28988489/fatty-infiltration-of-the-minor-salivary-glands-is-a-selective-feature-of-aging-but-not-sj%C3%A3-gren-s-syndrome
#13
Kerry M Leehan, Nathan P Pezant, Astrid Rasmussen, Kiely Grundahl, Jacen S Moore, Lida Radfar, David M Lewis, Donald U Stone, Christopher J Lessard, Nelson L Rhodus, Barbara M Segal, C Erick Kaufman, R Hal Scofield, Kathy L Sivils, Courtney Montgomery, A Darise Farris
OBJECTIVE: Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non-SS sicca (nSS). METHODS: Minor SG biopsy samples from 134 subjects with pSS (n = 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n = 4-6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD)...
October 8, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28987967/the-bouba-kiki-effect-and-its-relation-to-the-autism-quotient-aq-in-autistic-adolescents
#14
Rinat Gold, Osnat Segal
The bouba-kiki effect refers to the correspondence between arbitrary visual and auditory stimuli. Previous studies indicate ASD persons' reduced bouba-kiki effect compared to controls. This study examines the relation between ASD symptomology and performance on the bouba-kiki task. Twenty ASD participants and 20 matched controls were presented the bouba-kiki task. Autism-Quotient (AQ) scores and several cognitive measures were obtained for all participants. Results demonstrate that among all measures, only AQ scores were significantly correlated to the performance on the bouba-kiki task in the ASD group...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28986514/editorial-nuclear-medicine-training-in-the-united-states
#15
George M Segall, Erin E Grady, Joanna R Fair, Munir V Ghesani, Leonie Gordon
No abstract text is available yet for this article.
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28983385/can-geriatric-psychiatry-patients-complete-symptoms-self-reports-using-tablets-a-randomized-study
#16
Ghizlane Moussaoui, Ching Yu, Vincent Laliberté, Dominique Elie, Artin A Mahdanian, Benjamin Dawson, Marilyn Segal, Karl J Looper, Rej Soham
BACKGROUND: With our aging population and limited number of geriatric psychiatrists, innovations must be made in order to meet the growing demands for geriatric psychiatry services. Emerging technologies could greatly improve access to care and systematic data collection. METHODS: This randomized study compared completion rates and time to completion (primary outcomes) when using iPad technology vs. traditional paper forms to complete self-report psychiatric symptoms...
September 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28981145/rapid-versus-slow-ascending-vasodilatation-intercellular-conduction-versus-flow-mediated-signalling-with-tetanic-versus-rhythmic-muscle-contractions
#17
Shenghua Y Sinkler, Steven S Segal
In response to exercise, vasodilatation initiated within the microcirculation of skeletal muscle ascends the resistance network into upstream feed arteries (FAs) located external to the tissue. Ascending vasodilatation (AVD) is essential to reducing FA resistance that otherwise restricts blood flow into the microcirculation. We tested the hypothesis that signalling events underlying AVD vary with the intensity and duration of muscle contraction. In the gluteus maximus muscle of anaesthetized male C57BL/6 mice (age, 3-4 months), brief tetanic contraction (100 Hz, 500 ms) evoked rapid onset vasodilatation (ROV) in FAs that peaked within 4 s...
October 5, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28979777/changes-in-treatment-of-hyperglycemia-in-a-hypertensive-type-2-diabetes-population-as-renal-function-declines
#18
Larry A Weinrauch, Alissa R Segal, George P Bayliss, Jiankang Liu, Eric Wisniewski, John A D'Elia
BACKGROUND: Cardiovascular complications associated with expensive noninsulin agents for type 2 diabetes are the focus of concern in light of the risk of kidney dysfunction with aging. Head-to-head comparisons are unavailable to guide the choice of new drugs for hyperglycemia in patients with type 2 diabetes, decreased estimated glomerular filtration rate (eGFR) and increased cardiovascular risk. A first approach would be to document current medication choices. METHODS: All prescriptions for 10 151 patients (5623 males/4528 females) with both type 2 diabetes and hypertension seen two or  more times during a 5-year period (2007-12) at Joslin Diabetes Center were evaluated...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28976407/contributors-to-screening-positive-for-mental-illness-in-lebanon-s-shatila-palestinian-refugee-camp
#19
Steven P Segal, Vicky C Khoury, Ramy Salah, Jess Ghannam
This study evaluates contributors to the mental health status of Palestinians, Syrians, and nonrefugee residents of Lebanon's Shatila Refugee Camp. Primary health care clinic patients in Shatila were screened for mental illness between 2012 and 2013 using the K6, the Primary Care Posttraumatic Stress Disorder (PTSD), and the Modified Mini International Neuropsychiatric Interview. Logistic regressions enabled the consideration of potential contributors to participants' positive mental illness screens. The sample (n = 254) included 63...
October 2, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28975876/twin-studies-in-brazil-projects-and-plans-twin-research-infant-twins-viewing-of-social-scenes-religiosity-and-substance-abuse-down-syndrome-among-twins-twin-case-of-chronic-periodontitis-in-the-news-the-twin-property-brothers-twins-with-cerebral-palsy-twins
#20
Nancy L Segal
Twin research in Brazil twin has expanded enormously in recent years, engaging the interests and efforts of many investigators, students and twins. Descriptions and brief summaries of this work and talks given by investigators at local conferences are presented, based on my four-city lecture tour. This is followed by summaries of twin research on infants' viewing of social scenes, religiosity and substance abuse, Down syndrome, and chronic periodontitis. This article concludes with twin-related news and information of general interest, including identical twin property designers, twins with cerebral palsy, twins affected with the Zika virus, a pair of twin writers, twins in sports, and a set of quadruplets from my childhood neighborhood in Riverdale, New York...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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