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https://www.readbyqxmd.com/read/29223004/towards-utilization-of-the-human-genome-and-microbiome-for-personalized-nutrition
#1
REVIEW
Stavros Bashiardes, Anastasia Godneva, Eran Elinav, Eran Segal
Generalized dietary and lifestyle guidelines have been formulated and published for decades now from a variety of relevant agencies in an attempt to guide people towards healthy choices. As the pandemic rise in metabolic diseases continues to increase, it has become clear that the one-fit-for-all diet approach does not work and that there is a significant variation in inter-individual responses to diet and lifestyle interventions. Recent technological advances have given an unprecedented insight into the sources of this variation, pointing towards our genome and microbiome as potentially and previously under-explored culprits contributing to individually unique dietary responses...
December 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29215971/a-mediterranean-style-dietary-intervention-supplemented-with-fish-oil-improves-diet-quality-and-mental-health-in-people-with-depression-a-randomized-controlled-trial-helfimed
#2
Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Sarah Blunden, Barbara Meyer, Leonie Segal, Bernhard T Baune, Kerin O'Dea
OBJECTIVES: We investigated whether a Mediterranean-style diet (MedDiet) supplemented with fish oil can improve mental health in adults suffering depression. METHODS: Adults with self-reported depression were randomized to receive fortnightly food hampers and MedDiet cooking workshops for 3 months and fish oil supplements for 6 months, or attend social groups fortnightly for 3 months. Assessments at baseline, 3 and 6 months included mental health, quality of life (QoL) and dietary questionnaires, and blood samples for erythrocyte fatty acid analysis...
December 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29206063/age-discrimination-in-out-of-hospital-cardiac-arrest-care-a-case-control-study
#3
Eric Wiel, Christophe Di Pompéo, Nicolas Segal, Gérald Luc, Jean-Baptiste Marc, Carine Vanderstraeten, Carlos El Khoury, Joséphine Escutnaire, Karim Tazarourte, Pierre-Yves Gueugniaud, Hervé Hubert
BACKGROUND: Although some studies have questioned whether cardiopulmonary resuscitation (CPR) in older people could be futile, age is not considered an essential out-of-hospital cardiac arrest (OHCA) prognostic factor. However, in the daily clinical practice of mobile medical teams (MMTs), age seems to be an important factor affecting OHCA care. AIMS: The purpose of this study was to compare OHCA care and outcomes between young patients (<65 years old) and older patients...
December 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29205422/systematic-review-ileoanal-pouch-microbiota-in-health-and-disease
#4
REVIEW
J P Segal, S Oke, G L Hold, S K Clark, O D Faiz, A L Hart
BACKGROUND: The resident gut microbiota is essential for physiological processes; the disturbance of its balance is linked to intestinal inflammation. The ileoanal pouch is a model for the study of intestinal inflammation, as inflammation of the pouch is common and mostly develops within 12 months following ileostomy closure. This allows the longitudinal study of the microbiota, giving insight into the microbiota changes during transition from a normal to an inflamed pouch. AIM: To explore the literature on the microbiota of the ileoanal pouch in health and disease...
December 5, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29204811/impact-of-a-patient-facing-enhanced-genomic-results-report-to-improve-understanding-engagement-and-communication
#5
Janet L Williams, Alanna Kulchak Rahm, Doris T Zallen, Heather Stuckey, Kara Fultz, Audrey L Fan, Michele Bonhag, Lynn Feldman, Michael M Segal, Marc S Williams
"The objective of this study was to" test the effectiveness of an enhanced genomic report on patient-centered outcome domains including communication, engagement and satisfaction. "Study design utilized" a prospective, randomized, mixed-methods desctiptive study of a whole genome sequencing results report, GenomeCOMPASS™, that was accessed by providers through the electronic health record and by patients through the associated patient portal. "The study was set in" an integrated healthcare delivery system in central Pennsylvania...
December 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29202942/microbiome-at-the-frontier-of-personalized-medicine
#6
REVIEW
Purna C Kashyap, Nicholas Chia, Heidi Nelson, Eran Segal, Eran Elinav
The genomic revolution promises to transform our approach to treat patients by individualizing treatments, reducing adverse events, and decreasing health care costs. The early advances using this have been realized primarily by optimizing preventive and therapeutic approaches in cancer using human genome sequencing. The ability to characterize the microbiome, which includes all the microbes that reside within and upon us and all their genetic elements, using next-generation sequencing allows us to now incorporate this important contributor to human disease into developing new preventive and therapeutic strategies...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29197047/correction-to-long-term-over-10-years-retrospective-follow-up-of-laparoscopic-adjustable-gastric-banding
#7
Dvir Froylich, Tamar Abramovich-Segal, Guy Pascal, Ivy Haskins, Boaz Appel, Naama Kafri, David Hazzan
In the original article the spelling of author Naama Kafri was incorrect.
December 1, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29196530/from-the-abnm-improvement-in-medical-practice
#8
George M Segall
No abstract text is available yet for this article.
December 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29195081/corrigendum-to-klinefelter-s-syndrome-47-xxy-is-in-excess-among-men-with-sj%C3%A3-gren-s-syndrome-clin-immunol-168-2016-25-29
#9
Valerie M Harris, Rohan Sharma, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Marta E Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Katherine A Siminovitch, Wan-Fai Ng, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, TorstenWitte, Xavier Mariette, Christopher J Lessard, John B Harley, Kathy L Sivils, R Hal Scofield
No abstract text is available yet for this article.
November 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29183177/low-apgar-scores-in-term-newborns-and-long-term-gastro-intestinal-morbidity-a-population-based-cohort-study-with-up-to-18%C3%A2-years-of-follow-up
#10
Noa Leybovitz-Haleluya, Tamar Wainstock, Eyal Sheiner, Idit Segal, Daniella Landau, Asnat Walfisch
INTRODUCTION: Low Apgar scores (< 7) measured at age 5 minutes can predict short-term infant morbidity and mortality. Although an association exists between low Apgar scores and neuropsychological disorders, other childhood disorders were not thoroughly studied. We aimed to study the possible association between low 5-minute Apgar scores in term newborns and their long-term childhood gastrointestinal (GI) morbidity. METHODS: A population based cohort analysis was performed comparing total and different subtypes of GI related pediatric hospitalizations among newborns with normal (≥ 7) and low (< 7) 5-minute Apgar scores...
November 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29182068/can-clinical-subtypes-contribute-to-genetic-studies-on-major-depression
#11
Marco Antonio Caldieraro, Carolina Blaya, Ana Carolina Brusius-Facchin, Francyne Kubaski, Sandra Leistner-Segal, Marcelo P Fleck
No abstract text is available yet for this article.
December 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29179938/assessment-of-outpatient-commitment-in-randomised-trials
#12
Steven P Segal
No abstract text is available yet for this article.
December 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/29171661/a-randomised-controlled-trial-comparing-high-flow-nasal-oxygen-with-standard-management-for-conscious-sedation-during-bronchoscopy
#13
N Douglas, I Ng, F Nazeem, K Lee, P Mezzavia, R Krieser, D Steinfort, L Irving, R Segal
Traditional conscious sedation for endobronchial ultrasound procedures places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk. We designed a parallel-group randomised controlled trial of high-flow nasal oxygen at a flow rate of 30-70 l.min(-1) via nasal cannulae, compared with standard oxygen therapy at 10 l.min(-1) via a bite block in adults planned for conscious sedation for endobronchial ultrasound. The primary outcome was the proportion of patients experiencing desaturation (defined as SpO2 < 90%)...
November 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29169036/frequency-of-lethal-means-assessment-among-emergency-department-patients-with-a-positive-suicide-risk-screen
#14
Marian E Betz, Mack Kautzman, Daniel L Segal, Ivan Miller, Carlos A Camargo, Edwin D Boudreaux, Sarah A Arias
Prior work from surveys and limited populations suggests many emergency department (ED) patients with suicide risk do not have documented lethal means assessments (e.g., being asked about home firearms). The specific objectives of this study were to, in an ED with universal screening for suicide risk: (1) estimate how often ED providers documented lethal means assessment for suicidal patients, and (2) compare patients with and without documented lethal means assessments. We reviewed 800 total charts from a random sample of adults in three a priori age groups (18-34 years; 35-59 years; ≥ 60 years) with a positive suicide risk screen from 8/2014 to 12/2015...
November 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29166786/understanding-concentrated-insulins-a-systematic-review-of-randomized-controlled-trials
#15
Fernando Ovalle, Alissa R Segal, John E Anderson, Michael R Cohen, Tina M Morwick, Jeffrey A Jackson
OBJECTIVE: To compile, analyze, and summarize the literature on concentrated insulins (i.e., concentrations >100 units/mL) from randomized controlled trials and derive guidance on appropriate use of these agents. METHODS: Searches were conducted in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and Trialtrove® (through April 2016) and ClinicalTrials.gov (through April 2017) for Phase 1-4 clinical studies using concentrated insulins. Selected studies included multiple-arm, randomized controlled trials evaluating subcutaneously administered concentrated insulins...
November 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29164872/on-chip-protein-pre-concentration-for-enhancing-the-sensitivity-of-porous-silicon-biosensors
#16
Sofia Arshavsky Graham, Naama Massad-Ivanir, Federico Paratore, Thomas Scheper, Moran Bercovici, Ester Segal
Porous silicon (PSi) nanomaterials have been widely studied as label-free optical biosensors for proteins detection. However, these biosensors' performance, specifically in terms of their sensitivity (which is typically in the micromolar range), is insufficient for many applications. Herein, we present a proof-of-concept application of the electrokinetic isotachophoresis (ITP) technique for real-time pre-concentration of a target protein on a PSi biosensor. With ITP, a highly concentrated target zone is delivered to the sensing area, where the protein target is captured by immobilized aptamers...
November 22, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29162707/cd4-t-cells-orchestrate-lethal-immune-pathology-despite-fungal-clearance-during-cryptococcus-neoformans-meningoencephalitis
#17
Lori M Neal, Enze Xing, Jintao Xu, Jessica L Kolbe, John J Osterholzer, Benjamin M Segal, Peter R Williamson, Michal A Olszewski
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune responses within this immune-privileged site. CD4(+) T cells have demonstrated roles in anticryptococcal defenses, but increasing evidence suggests that they may contribute to clinical deterioration and pathology in both HIV-positive (HIV+) and non-HIV patients who develop immune reconstitution inflammatory syndrome (IRIS) and post-infectious inflammatory response syndrome (PIIRS), respectively...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162557/self-management-and-clinical-decision-support-for-patients-with-complex-chronic-conditions-through-the-use-of-smartphone-based-telemonitoring-randomized-controlled-trial-protocol
#18
Emily Seto, Patrick Ware, Alexander G Logan, Joseph A Cafazzo, Kenneth R Chapman, Phillip Segal, Heather J Ross
BACKGROUND: The rising prevalence of chronic illnesses hinders the sustainability of the health care system because of the high cost of frequent hospitalizations of patients with complex chronic conditions. Clinical trials have demonstrated that telemonitoring can improve health outcomes, but they have generally been limited to single conditions such as diabetes, hypertension, or heart failure. Few studies have examined the impact of telemonitoring on complex patients with multiple chronic conditions, although these patients may benefit the most from this technology...
November 21, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29159551/long-term-over-10%C3%A2-years-retrospective-follow-up-of-laparoscopic-adjustable-gastric-banding
#19
Dvir Froylich, Tamar Abramovich-Segal, Guy Pascal, Ivy Haskins, Boaz Appel, Naama Kafry, David Hazzan
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) placements have progressively decreased in recent years. This is related to poor long-term weight loss outcomes and necessity for revision or removal of these bands. Long-term outcome results following LAGB are limited. The aim of our study was to determine the long-term outcome after LAGB at our institution. OBJECTIVES: The aim of our study was to determine the long-term outcome after LAGB at our institution...
October 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29158528/fine-mapping-of-genetic-loci-driving-spontaneous-clearance-of-hepatitis-c-virus-infection
#20
Hailiang Huang, Priya Duggal, Chloe L Thio, Rachel Latanich, James J Goedert, Alessandra Mangia, Andrea L Cox, Gregory D Kirk, Shruti Mehta, Jasneet Aneja, Laurent Alric, Sharyne M Donfield, Matthew E Cramp, Salim I Khakoo, Leslie H Tobler, Michael Busch, Graeme J Alexander, Hugo R Rosen, Brian R Edlin, Florencia P Segal, Georg M Lauer, David L Thomas, Mark J Daly, Raymond T Chung, Arthur Y Kim
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population...
November 20, 2017: Scientific Reports
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