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https://www.readbyqxmd.com/read/27875368/analgesic-effect-and-functional-improvement-caused-by-radiofrequency-treatment-of-genicular-nerves-in-patients-with-advanced-osteoarthritis-of-the-knee-until-1-year-following-treatment
#1
María M Santana Pineda, Luc E Vanlinthout, Ana Moreno Martín, Jan van Zundert, Fernando Rodriguez Huertas, José P Novalbos Ruiz
BACKGROUND AND OBJECTIVES: Radiofrequency ablation of genicular nerves has proved to be successful in relieving pain and incapacity caused by osteoarthritis of the knee. However, long-term efficacy of such a treatment remains to be assessed. The current study aimed to reproduce radiofrequency neurotomy of genicular nerves to manage gonarthrosis pain and disability and establish therapeutic response until 1 year after intervention. METHODS: This single-center, prospective, observational, noncontrolled, longitudinal study included patients with grade 3 to 4 gonarthrosis suffering from intractable knee pain, scoring 5 or more on the visual analog scale (VAS) during >6 months...
November 22, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27828796/perioperative-anesthesia-care-and-tumor-progression
#2
Mir W Sekandarzad, André A J van Zundert, Philipp B Lirk, Chris W Doornebal, Markus W Hollmann
This narrative review discusses the most recent up-to-date findings focused on the currently available "best clinical practice" regarding perioperative anesthesia care bundle factors and their effect on tumor progression. The main objective is to critically appraise the current literature on local anesthetics, regional outcome studies, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) and their ability to decrease recurrence in patients undergoing cancer surgery. A brief discussion of additional topical perioperative factors relevant to the anesthesiologist including volatile and intravenous anesthetics, perioperative stress and anxiety, nutrition, and immune stimulation is included...
November 8, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27819269/structural-basis-of-gm-csf-and-il-2-sequestration-by-the-viral-decoy-receptor-gif
#3
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo C P van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre M J J Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive...
November 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27804108/tracheal-extubation-of-the-adult-intensive-care-patient-with-a-predicted-difficult-airway-a-narrative-review
#4
REVIEW
D J Sturgess, K B Greenland, S Senthuran, F A Ajvadi, A van Zundert, M G Irwin
Management of the difficult airway is an important, but as yet poorly-studied, component of intensive care management. Although there has been a strong emphasis on prediction and intubation of the difficult airway, safe extubation of the patient with a potentially difficult airway has not received the same attention. Extubation is a particularly vulnerable time for the critically ill patient and, because of the risks involved and the consequences of failure, it warrants specific consideration. The Royal College of Anaesthetists 4th National Audit Project highlighted differences in the incidence and consequences of major complications during airway management between the operating room and the critical care environment...
November 2, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27802573/sense-and-simplicity-in-haddock-scoring-lessons-from-casp-capri-round1
#5
A Vangone, J P G L M Rodrigues, L C Xue, G C P van Zundert, C Geng, Z Kurkcuoglu, M Nellen, S Narasimhan, E Karaca, M van Dijk, A S J Melquiond, K M Visscher, M Trellet, P L Kastritis, A M J J Bonvin
Our information-driven docking approach HADDOCK is a consistent top predictor and scorer since the start of its participation in the CAPRI community-wide experiment. This sustained performance is due, in part, to its ability to integrate experimental data and/or bioinformatics information into the modelling process, and also to the overall robustness of the scoring function used to assess and rank the predictions. In the CASP-CAPRI Round 1 scoring experiment we successfully selected acceptable/medium quality models for 18/14 of the 25 targets - a top-ranking performance among all scorers...
November 1, 2016: Proteins
https://www.readbyqxmd.com/read/27798002/-omics-biomarkers-associated-with-chronic-low-back-pain-protocol-of-a-retrospective-longitudinal-study
#6
Massimo Allegri, Manuela De Gregori, Cristina E Minella, Catherine Klersy, Wei Wang, Moira Sim, Christian Gieger, Judith Manz, Iain K Pemberton, Jane MacDougall, Frances Mk Williams, Jan Van Zundert, Klaas Buyse, Gordan Lauc, Ivan Gudelj, Dragan Primorac, Andrea Skelin, Yurii S Aulchenko, Lennart C Karssen, Leonardo Kapural, Richard Rauck, Guido Fanelli
INTRODUCTION: Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27763918/verification-of-nasopharyngeal-temperature-probes-they-are-not-always-where-you-think-they-are
#7
André van Zundert, Kerstin Wyssusek, Vernon Vivian
No abstract text is available yet for this article.
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27746312/als-new-molecular-mechanisms-and-emerging-therapeutic-targets
#8
EDITORIAL
Brigitte van Zundert
No abstract text is available yet for this article.
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27689934/epigenetic-signatures-at-the-runx2-p1-and-sp7-gene-promoters-control-osteogenic-lineage-commitment-of-umbilical-cord-derived-mesenchymal-stem-cells
#9
Hugo Sepulveda, Rodrigo Aguilar, Catalina P Prieto, Francisco Bustos, Sócrates Aedo, José Lattus, Brigitte van Zundert, Veronica Palma, Martin Montecino
Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent stem cells for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion are poorly understood. Particularly, epigenetic control operating at the promoter regions of the two master regulators of the osteogenic program, RUNX2/P57 and SP7 has not yet been described in WJ-MSCs. Via quantitative PCR profiling and chromatin immunoprecipitation (ChIP) studies here we analyze the ability of WJ-MSCs to engage osteoblast lineage...
September 30, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27663451/a-randomized-comparison-between-intravenous-and-perineural-dexamethasone-for-ultrasound-guided-axillary-block
#10
Julian Aliste, Prangmalee Leurcharusmee, Phatthanaphol Engsusophon, Aida Gordon, Giuliano Michelagnoli, Chonticha Sriparkdee, Worakamol Tiyaprasertkul, Dana Q Tran, Tom C R V Van Zundert, Roderick J Finlayson, De Q H Tran
BACKGROUND: This randomized double-blinded trial compared the effect of intravenous and perineural dexamethasone (8 mg) on the duration of motor block for ultrasound (US)-guided axillary brachial plexus block (AXB). METHODS: Patients undergoing upper limb surgery with US-guided AXB were randomly allocated to receive preservative-free dexamethasone (8 mg) via intravenous (n = 75) or perineural (n = 75) administration. The local anesthetic agent, 1% lidocaine -0...
September 23, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27608347/anaesthetists-experiences-with-the-early-labour-epidural-recommendation-for-obese-parturients-a-qualitative-study
#11
V A Eley, L K Callaway, A A J van Zundert, J Lipman, C Gallois
Caring for obese pregnant women presents challenges for all medical professionals. Despite a lack of supporting evidence, expert opinion and international guidelines suggest early labour epidural insertion for obese women. Anecdotally this is not supported by all anaesthetists. This qualitative study explored the experiences of anaesthetists regarding early epidural analgesia in obese parturients, to answer the research question: Are anaesthetists consistent in how they apply early epidural analgesia in obese parturients? Personal in-depth interviews with 42 specialist anaesthetists working in south-east Queensland, Australia, were completed between February and April, 2015...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27608338/does-objective-measurement-of-tracheal-tube-cuff-pressures-minimise-adverse-effects-and-maintain-accurate-cuff-pressures-a-systematic-review-and-meta-analysis
#12
C A Hockey, A A J van Zundert, J D Paratz
Correct inflation pressures of the tracheal cuff are recommended to ensure adequate ventilation and prevent aspiration and adverse events. However there are conflicting views on which measurement to employ. The aim of this review was to examine whether adjustment of cuff pressure guided by objective measurement, compared with subjective measurement or observation of the pressure value alone, was able to prevent patient-related adverse effects and maintain accurate cuff pressures. A search of PubMed, Web of Science, Embase, CINAHL and ScienceDirect was conducted using keywords 'cuff pressure' and 'measure*' and related synonyms...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27608337/anaesthetic-management-of-obese-parturients-what-is-the-evidence-supporting-practice-guidelines
#13
V A Eley, A A J van Zundert, J Lipman, L K Callaway
Increasing rates of obesity in western populations present management difficulties for clinicians caring for obese pregnant women. Various governing bodies have published clinical guidelines for the care of obese parturients. These guidelines refer to two components of anaesthetic care: anaesthetic consultation in the antenatal period for women with a body mass index (BMI) ≥ 40 kg/m(2) and the provision of early epidural analgesia in labour. These recommendations are based on the increased incidence of obstetric complications and the predicted risks and difficulties in providing anaesthetic care...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27562554/past-present-and-future-of-informed-consent-in-pain-and-genomics-research-challenges-facing-global-medical-community
#14
Christian Compagnone, Michael E Schatman, Richard L Rauck, Jan Van Zundert, Monika Kraus, Dragan Primorac, Frances Williams, Massimo Allegri, Gloria Saccani Jordi, Guido Fanelli
In recent decades, there has been a revision of the role of institutional review boards with the intention of protecting human subjects from harm and exploitation in research. Informed consent aims to protect the subject by explaining all of the benefits and risks associated with a specific research project. To date, there has not been a review published analyzing issues of informed consent in research in the field of genetic/Omics in subjects with chronic pain, and the current review aims to fill that gap in the ethical aspects of such investigation...
August 26, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27543520/continuing-to-excel-in-anaesthesia-through-the-big-five-teaching-training-testing-quality-and-research
#15
EDITORIAL
A A J Van Zundert, S P Gatt, R P Mahajan
No abstract text is available yet for this article.
September 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27507699/silencing-strategies-for-therapy-of-sod1-mediated-als
#16
REVIEW
Brigitte van Zundert, Robert H Brown
Amyotrophic lateral sclerosis (ALS) is an adult-onset, lethal, paralytic disorder caused by the degeneration of motor neurons. Our understanding of this disease has been greatly facilitated by studies of familial ALS caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Evidence indicates that misfolded wild-type SOD1 may also be pathogenic in sporadic ALS. Mutant SOD1 is neurotoxic through multiple mechanisms. Because the pathogenicity of mutant SOD1 is proportional to the dose of the toxic protein, a rational approach to treating SOD1-related ALS is to reduce levels of the toxic SOD1 species...
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27428159/asymmetric-jugular-veins-implication-for-central-venous-access-in-the-icu
#17
Michaël J Bos, Walther N K A van Mook, André A J van Zundert
No abstract text is available yet for this article.
August 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27376929/interactive-and-additive-influences-of-gender-bmi-and-apolipoprotein-4-on-cognition-in-children-chronically-exposed-to-high-concentrations-of-pm2-5-and-ozone-apoe-4-females-are-at-highest-risk-in-mexico-city
#18
Lilian Calderón-Garcidueñas, Valerie Jewells, Carolina Galaz-Montoya, Brigitte van Zundert, Angel Pérez-Calatayud, Eric Ascencio-Ferrel, Gildardo Valencia-Salazar, Marcela Sandoval-Cano, Esperanza Carlos, Edelmira Solorio, Hilda Acuña-Ayala, Ricardo Torres-Jardón, Amedeo D'Angiulli
Children's air pollution exposures are associated with systemic and brain inflammation and the early hallmarks of Alzheimer's disease (AD). The Apolipoprotein E (APOE) 4 allele is the most prevalent genetic risk for AD, with higher risk for women. We assessed whether gender, BMI, APOE and metabolic variables in healthy children with high exposures to ozone and fine particulate matter (PM2.5) influence cognition. The Wechsler Intelligence Scale for Children (WISC-R) was administered to 105 Mexico City children (12...
October 2016: Environmental Research
https://www.readbyqxmd.com/read/27318041/defining-the-limits-and-reliability-of-rigid-body-fitting-in-cryo-em-maps-using-multi-scale-image-pyramids
#19
G C P van Zundert, A M J J Bonvin
Cryo-electron microscopy provides fascinating structural insight into large macromolecular machines at increasing detail. Despite significant advances in the field, the resolution of the resulting three-dimensional images is still typically insufficient for de novo model building. To bridge the resolution gap and give an atomic interpretation to the data, high-resolution models are typically placed into the density as rigid bodies. Unfortunately, this is often done manually using graphics software, a subjective method that can lead to over-interpretation of the data...
August 2016: Journal of Structural Biology
https://www.readbyqxmd.com/read/27290948/comparison-of-the-diameter-cross-sectional-area-and-position-of-the-left-and-right-internal-jugular-vein-and-carotid-artery-in-adults-using-ultrasound
#20
Michaël J Bos, Rick F H J van Loon, Luke Heywood, Mitchell P Morse, André A J van Zundert
STUDY OBJECTIVE: Central venous access is indicated for transduction of central venous pressure and the administration of inotropes in the perioperative period. The right internal jugular vein (RIJV) is cannulated preferentially over the left internal jugular vein (LIJV). Cannulation of the LIJV is associated with a higher complication rate and a perceived increased level of difficulty when compared with cannulation of the RIJV. Possible explanations for the higher complication rate include a smaller diameter and more anterior position relative to the corresponding carotid artery (CA) of the LIJV compared with the RIJV...
August 2016: Journal of Clinical Anesthesia
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