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https://www.readbyqxmd.com/read/28991062/electron-microscopy-of-dural-and-arachnoid-disruptions-after-subarachnoid-block
#1
Miguel Angel Reina, Anna Puigdellívol-Sánchez, Stephen P Gatt, José De Andrés, Alberto Prats-Galino, André van Zundert
BACKGROUND: It has been customary to attribute postdural puncture headache (PDPH) incidence and severity to size and nature of the dural hole produced during major neuraxial blockade or diagnostic dural puncture. Needle orientation in relation to the direction of dural fibers was thought to be of importance because of the propensity for horizontal bevel placement to cause cutting rather than splitting of the dural fibers. METHODS: In vitro punctures of stringently quality-controlled human dural sac specimens were obtained with 27-gauge (27G) Whitacre needle (n = 33), with 29G Quincke used parallel to the spinal axis (n = 30), and with 29G Quincke in perpendicular approach (n = 40)...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28962574/%C3%AE-v%C3%AE-3-integrin-regulates-astrocyte-reactivity
#2
Raúl Lagos-Cabré, Alvaro Alvarez, Milene Kong, Francesca Burgos-Bravo, Areli Cárdenas, Edgardo Rojas-Mancilla, Ramón Pérez-Nuñez, Rodrigo Herrera-Molina, Fabiola Rojas, Pascal Schneider, Mario Herrera-Marschitz, Andrew F G Quest, Brigitte van Zundert, Lisette Leyton
BACKGROUND: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4. Primary astrocytes express low levels of these receptors and are unresponsive to Thy-1; thus, inflammation and astrocyte reactivity might be necessary for Thy-1-induced responses. METHODS: Wild-type rat astrocytes (TNF-activated) or from human SOD1(G93A) transgenic mice (a neurodegenerative disease model) were used to evaluate cell migration, Thy-1 receptor levels, signaling molecules, and reactivity markers...
September 29, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28940354/videolaryngoscopy-vs-direct-laryngoscopy-use-by-experienced-anaesthetists-in-patients-with-known-difficult-airways-a-systematic-review-and-meta-analysis
#3
REVIEW
B M A Pieters, E H A Maas, J T A Knape, A A J van Zundert
Experienced anaesthetists can be confronted with difficult or failed tracheal intubations. We performed a systematic review and meta-analysis to ascertain if the literature indicated if videolaryngoscopy conferred an advantage when used by experienced anaesthetists managing patients with a known difficult airway. We searched PubMed, MEDLINE, Embase and the Cochrane central register of controlled trials up to 1 January 2017. Outcome parameters extracted from studies were: first-attempt success of tracheal intubation; time to successful intubation; number of intubation attempts; Cormack and Lehane grade; use of airway adjuncts (e...
September 22, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28730688/sense-and-simplicity-in-haddock-scoring-lessons-from-casp-capri-page-418
#4
A Vangone, J P G L M Rodrigues, L C Xue, G C P van Zundert, C Geng, Z Kurkcuoglu, M Nellen, S Narasimhan, E Karaca, M van Dijk, A S J Melquiond, K M Visscher, M Trellet, P L Kastritis, A M J J Bonvin
No abstract text is available yet for this article.
August 2017: Proteins
https://www.readbyqxmd.com/read/28700369/pulsed-radiofrequency-in-chronic-pain
#5
Thibaut Vanneste, Astrid Van Lantschoot, Koen Van Boxem, Jan Van Zundert
PURPOSE OF REVIEW: The increasing number of publications on pulsed radiofrequency (PRF) treatment of chronic pain reflects the interest for this technique. We summarize the literature for PRF in five indications: radicular pain, trigeminal neuralgia (TN), occipital neuralgia, shoulder and knee pain. RECENT FINDINGS: The efficacy and safety of PRF adjacent to the dorsal root ganglion was documented on cervical and on lumbar level.PRF has been used for the treatment of TN...
October 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28700368/regional-anesthesia-and-analgesia-in-cancer-care-is-it-time-to-break-the-bad-news
#6
Mir W Sekandarzad, André A J van Zundert, Chris W Doornebal, Markus W Hollmann
PURPOSE OF REVIEW: There is ongoing controversy regarding the tumor-protective effects of regional anesthesia in patients undergoing cancer surgery. Evidence of up-to-date systematic reviews will be presented alongside recent updates on the effects of opioids and local anesthetics. RECENT FINDINGS: In recent years, the literature regarding the effects of regional anesthesia techniques on cancer recurrence has raised many unanswered questions. Ongoing randomized controlled trials may not be able to shed light on the controversial discussion regarding the tumor protective effects of regional anesthesia because the expected effect size and event rate in those studies may be overstated...
October 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28520806/als-skeletal-muscle-shows-enhanced-tgf-%C3%AE-signaling-fibrosis-and-induction-of-fibro-adipogenic-progenitor-markers
#7
David Gonzalez, Osvaldo Contreras, Daniela L Rebolledo, Juan Pablo Espinoza, Brigitte van Zundert, Enrique Brandan
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate that skeletal muscle contributes to disease progression; however the molecular mechanisms remain elusive. Fibrosis is a common feature in skeletal muscle under chronic damage conditions such as those caused by muscular dystrophies or denervation. However, the exact mechanisms of fibrosis induction and the cellular bases of this pathological response are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28510747/-failed-supraglottic-airway-an-algorithm-for-suboptimally-placed-supraglottic-airway-devices-based-on-videolaryngoscopy
#8
A A J Van Zundert, S P Gatt, C M Kumar, T C R V Van Zundert, J J Pandit
No abstract text is available yet for this article.
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28497935/the-lma-flexible-time-to-celebrate-a-unique-extraglottic-airway-device
#9
Tom C van Zundert, Davide Cattano
No abstract text is available yet for this article.
September 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28459826/validation-of-standard-operating-procedures-in-a-multicenter-retrospective-study-to-identify-omics-biomarkers-for-chronic-low-back-pain
#10
MULTICENTER STUDY
Concetta Dagostino, Manuela De Gregori, Christian Gieger, Judith Manz, Ivan Gudelj, Gordan Lauc, Laura Divizia, Wei Wang, Moira Sim, Iain K Pemberton, Jane MacDougall, Frances Williams, Jan Van Zundert, Dragan Primorac, Yurii Aulchenko, Leonardo Kapural, Massimo Allegri
Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine). Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories) to obtain robust and reproducible results...
2017: PloS One
https://www.readbyqxmd.com/read/28448394/in-response
#11
Sam Baete, Gerd Vercruysse, Margot Vander Laenen, Pieter De Vooght, Dimitri Dylst, Jeroen van Melkebeek, Maud Beran, Jan Van Zundert, René Heylen, Willem Boer, Sam Van Boxstael, Tom Fret, Hans Verhelst, Cathy De Deyne, Frank Jans, Pascal Vanelderen
No abstract text is available yet for this article.
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28426589/open-access-crowd-sourced-repository-of-anesthesia-information-wiki-anesthesia-as-antidote-to-inaccurate-internet-based-resources
#12
André A J Van Zundert, Stephen P Gatt, Ravi P Mahajan
No abstract text is available yet for this article.
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28204715/response-to-dr-freo-and-dr-calldero
#13
Koen Van Boxem, Nelleke de Meij, Jacob Patijn, Jan Wilmink, Maarten van Kleef, Jan Van Zundert, Alfons Kessels
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28203766/vision-guided-placement-of-supraglottic-airway-device-prevents-airway-obstruction-a-prospective-audit
#14
A A J Van Zundert, S P Gatt, C M Kumar, T C R V Van Zundert
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28160495/nmda-receptor-subunit-composition-controls-dendritogenesis-of-hippocampal-neurons-through-camkii-creb-p-and-h3k27ac
#15
Fernando J Bustos, Nur Jury, Pablo Martinez, Estibaliz Ampuero, Matias Campos, Sebastian Abarzúa, Karen Jaramillo, Susanne Ibing, Muriel D Mardones, Henny Haensgen, Julia Kzhyshkowska, Maria Florencia Tevy, Rachael Neve, Magdalena Sanhueza, Lorena Varela-Nallar, Martín Montecino, Brigitte van Zundert
Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and promote plasticity, NR1NR2A receptors are mainly expressed in mature neurons and induce circuit stability. How the different subunits regulate these processes is unclear, but this is likely related to the presence of their distinct C-terminal sequences that couple different signaling proteins...
December 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28128448/chronic-infusion-of-sod1-g93a-astrocyte-secreted-factors-induces-spinal-motoneuron-degeneration-and-neuromuscular-dysfunction-in-healthy-rats
#16
Uri N Ramírez-Jarquín, Fabiola Rojas, Brigitte van Zundert, Ricardo Tapia
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non-cell-autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were treated with conditioned media derived from primary mouse astrocytes (ACM) that express human (h) SOD1(G93A) (ACM-hG93A) via chronic osmotic pump infusion in the lumbar spinal cord...
October 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28107276/the-effect-of-deep-versus-moderate-neuromuscular-block-on-surgical-conditions-and-postoperative-respiratory-function-in-bariatric-laparoscopic-surgery-a-randomized-double-blind-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Sam Baete, Gerd Vercruysse, Margot Vander Laenen, Pieter De Vooght, Jeroen Van Melkebeek, Dimitri Dylst, Maud Beran, Jan Van Zundert, René Heylen, Willem Boer, Sam Van Boxstael, Tom Fret, Hans Verhelst, Cathy De Deyne, Frank Jans, Pascal Vanelderen
BACKGROUND: In recent literature, it has been suggested that deep neuromuscular block (NMB) improves surgical conditions during laparoscopy; however, the evidence supporting this statement is limited, and this was not investigated in laparoscopic bariatric surgery. Moreover, residual NMB could impair postoperative respiratory function. We tested the hypotheses that deep NMB could improve the quality of surgical conditions for laparoscopic bariatric surgery compared with moderate NMB and investigated whether deep NMB puts patients at risk for postoperative respiratory impairment compared with moderate NMB...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27939290/the-disvis-and-powerfit-web-servers-explorative-and-integrative-modeling-of-biomolecular-complexes
#18
G C P van Zundert, M Trellet, J Schaarschmidt, Z Kurkcuoglu, M David, M Verlato, A Rosato, A M J J Bonvin
Structure determination of complex molecular machines requires a combination of an increasing number of experimental methods with highly specialized software geared toward each data source to properly handle the gathered data. Recently, we introduced the two software packages PowerFit and DisVis. These combine high-resolution structures of atomic subunits with density maps from cryo-electron microscopy or distance restraints, typically acquired by chemical cross-linking coupled with mass spectrometry, respectively...
February 3, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27875368/analgesic-effect-and-functional-improvement-caused-by-radiofrequency-treatment-of-genicular-nerves-in-patients-with-advanced-osteoarthritis-of-the-knee-until-1-year-following-treatment
#19
María M Santana Pineda, Luc E Vanlinthout, Ana Moreno Martín, Jan van Zundert, Fernando Rodriguez Huertas, José P Novalbos Ruiz
BACKGROUND AND OBJECTIVES: Radiofrequency ablation of genicular nerves has proved to be successful in relieving pain and incapacity caused by osteoarthritis of the knee. However, long-term efficacy of such a treatment remains to be assessed. The current study aimed to reproduce radiofrequency neurotomy of genicular nerves to manage gonarthrosis pain and disability and establish therapeutic response until 1 year after intervention. METHODS: This single-center, prospective, observational, noncontrolled, longitudinal study included patients with grade 3 to 4 gonarthrosis suffering from intractable knee pain, scoring 5 or more on the visual analog scale (VAS) during >6 months...
January 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27828796/perioperative-anesthesia-care-and-tumor-progression
#20
REVIEW
Mir W Sekandarzad, André A J van Zundert, Philipp B Lirk, Chris W Doornebal, Markus W Hollmann
This narrative review discusses the most recent up-to-date findings focused on the currently available "best clinical practice" regarding perioperative anesthesia care bundle factors and their effect on tumor progression. The main objective is to critically appraise the current literature on local anesthetics, regional outcome studies, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) and their ability to decrease recurrence in patients undergoing cancer surgery. A brief discussion of additional topical perioperative factors relevant to the anesthesiologist including volatile and intravenous anesthetics, perioperative stress and anxiety, nutrition, and immune stimulation is included...
May 2017: Anesthesia and Analgesia
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