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https://www.readbyqxmd.com/read/28426589/open-access-crowd-sourced-repository-of-anesthesia-information-wiki-anesthesia-as-antidote-to-inaccurate-internet-based-resources
#1
André A J Van Zundert, Stephen P Gatt, Ravi P Mahajan
No abstract text is available yet for this article.
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28204715/response-to-dr-freo-and-dr-calldero
#2
Koen Van Boxem, Nelleke de Meij, Jacob Patijn, Jan Wilmink, Maarten van Kleef, Jan Van Zundert, Alfons Kessels
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28203766/vision-guided-placement-of-supraglottic-airway-device-prevents-airway-obstruction-a-prospective-audit
#3
A A J Van Zundert, S P Gatt, C M Kumar, T C R V Van Zundert
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28160495/nmda-receptor-subunit-composition-controls-dendritogenesis-of-hippocampal-neurons-through-camkii-creb-p-and-h3k27ac
#4
Fernando J Bustos, Nur Jury, Pablo Martinez, Estibaliz Ampuero, Matias Campos, Sebastian Abarzúa, Karen Jaramillo, Susanne Ibing, Muriel D Mardones, Henny Haensgen, Julia Kzhyshkowska, Maria Florencia Tevy, Rachael Neve, Magdalena Sanhueza, Lorena Varela-Nallar, Martín Montecino, Brigitte van Zundert
Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and promote plasticity, NR1NR2A receptors are mainly expressed in mature neurons and induce circuit stability. How the different subunits regulate these processes is unclear, but this is likely related to the presence of their distinct C-terminal sequences that couple different signaling proteins...
February 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28128448/chronic-infusion-of-sod1-g93a-astrocyte-secreted-factors-induces-spinal-motoneuron-degeneration-and-neuromuscular-dysfunction-in-healthy-rats
#5
Uri N Ramírez-Jarquín, Fabiola Rojas, Brigitte van Zundert, Ricardo Tapia
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non-cell-autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were treated with conditioned media derived from primary mouse astrocytes (ACM) that express human (h) SOD1(G93A) (ACM-hG93A) via chronic osmotic pump infusion in the lumbar spinal cord...
January 27, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28107276/the-effect-of-deep-versus-moderate-neuromuscular-block-on-surgical-conditions-and-postoperative-respiratory-function-in-bariatric-laparoscopic-surgery-a-randomized-double-blind-clinical-trial
#6
Sam Baete, Gerd Vercruysse, Margot Vander Laenen, Pieter De Vooght, Jeroen Van Melkebeek, Dimitri Dylst, Maud Beran, Jan Van Zundert, René Heylen, Willem Boer, Sam Van Boxstael, Tom Fret, Hans Verhelst, Cathy De Deyne, Frank Jans, Pascal Vanelderen
BACKGROUND: In recent literature, it has been suggested that deep neuromuscular block (NMB) improves surgical conditions during laparoscopy; however, the evidence supporting this statement is limited, and this was not investigated in laparoscopic bariatric surgery. Moreover, residual NMB could impair postoperative respiratory function. We tested the hypotheses that deep NMB could improve the quality of surgical conditions for laparoscopic bariatric surgery compared with moderate NMB and investigated whether deep NMB puts patients at risk for postoperative respiratory impairment compared with moderate NMB...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27939290/the-disvis-and-powerfit-web-servers-explorative-and-integrative-modeling-of-biomolecular-complexes
#7
G C P van Zundert, M Trellet, J Schaarschmidt, Z Kurkcuoglu, M David, M Verlato, A Rosato, A M J J Bonvin
Structure determination of complex molecular machines requires a combination of an increasing number of experimental methods with highly specialized software geared toward each data source to properly handle the gathered data. Recently, we introduced the two software packages PowerFit and DisVis. These combine high-resolution structures of atomic subunits with density maps from cryo-electron microscopy or distance restraints, typically acquired by chemical cross-linking coupled with mass spectrometry, respectively...
February 3, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27875368/analgesic-effect-and-functional-improvement-caused-by-radiofrequency-treatment-of-genicular-nerves-in-patients-with-advanced-osteoarthritis-of-the-knee-until-1-year-following-treatment
#8
María M Santana Pineda, Luc E Vanlinthout, Ana Moreno Martín, Jan van Zundert, Fernando Rodriguez Huertas, José P Novalbos Ruiz
BACKGROUND AND OBJECTIVES: Radiofrequency ablation of genicular nerves has proved to be successful in relieving pain and incapacity caused by osteoarthritis of the knee. However, long-term efficacy of such a treatment remains to be assessed. The current study aimed to reproduce radiofrequency neurotomy of genicular nerves to manage gonarthrosis pain and disability and establish therapeutic response until 1 year after intervention. METHODS: This single-center, prospective, observational, noncontrolled, longitudinal study included patients with grade 3 to 4 gonarthrosis suffering from intractable knee pain, scoring 5 or more on the visual analog scale (VAS) during >6 months...
January 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27828796/perioperative-anesthesia-care-and-tumor-progression
#9
Mir W Sekandarzad, André A J van Zundert, Philipp B Lirk, Chris W Doornebal, Markus W Hollmann
This narrative review discusses the most recent up-to-date findings focused on the currently available "best clinical practice" regarding perioperative anesthesia care bundle factors and their effect on tumor progression. The main objective is to critically appraise the current literature on local anesthetics, regional outcome studies, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) and their ability to decrease recurrence in patients undergoing cancer surgery. A brief discussion of additional topical perioperative factors relevant to the anesthesiologist including volatile and intravenous anesthetics, perioperative stress and anxiety, nutrition, and immune stimulation is included...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27819269/structural-basis-of-gm-csf-and-il-2-sequestration-by-the-viral-decoy-receptor-gif
#10
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo C P van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre M J J Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive...
November 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27804108/tracheal-extubation-of-the-adult-intensive-care-patient-with-a-predicted-difficult-airway-a-narrative-review
#11
REVIEW
D J Sturgess, K B Greenland, S Senthuran, F A Ajvadi, A van Zundert, M G Irwin
Management of the difficult airway is an important, but as yet poorly-studied, component of intensive care management. Although there has been a strong emphasis on prediction and intubation of the difficult airway, safe extubation of the patient with a potentially difficult airway has not received the same attention. Extubation is a particularly vulnerable time for the critically ill patient and, because of the risks involved and the consequences of failure, it warrants specific consideration. The Royal College of Anaesthetists 4th National Audit Project highlighted differences in the incidence and consequences of major complications during airway management between the operating room and the critical care environment...
February 2017: Anaesthesia
https://www.readbyqxmd.com/read/27802573/sense-and-simplicity-in-haddock-scoring-lessons-from-casp-capri-round-1
#12
A Vangone, J P G L M Rodrigues, L C Xue, G C P van Zundert, C Geng, Z Kurkcuoglu, M Nellen, S Narasimhan, E Karaca, M van Dijk, A S J Melquiond, K M Visscher, M Trellet, P L Kastritis, A M J J Bonvin
Our information-driven docking approach HADDOCK is a consistent top predictor and scorer since the start of its participation in the CAPRI community-wide experiment. This sustained performance is due, in part, to its ability to integrate experimental data and/or bioinformatics information into the modelling process, and also to the overall robustness of the scoring function used to assess and rank the predictions. In the CASP-CAPRI Round 1 scoring experiment we successfully selected acceptable/medium quality models for 18/14 of the 25 targets - a top-ranking performance among all scorers...
March 2017: Proteins
https://www.readbyqxmd.com/read/27798002/-omics-biomarkers-associated-with-chronic-low-back-pain-protocol-of-a-retrospective-longitudinal-study
#13
Massimo Allegri, Manuela De Gregori, Cristina E Minella, Catherine Klersy, Wei Wang, Moira Sim, Christian Gieger, Judith Manz, Iain K Pemberton, Jane MacDougall, Frances Mk Williams, Jan Van Zundert, Klaas Buyse, Gordan Lauc, Ivan Gudelj, Dragan Primorac, Andrea Skelin, Yurii S Aulchenko, Lennart C Karssen, Leonardo Kapural, Richard Rauck, Guido Fanelli
INTRODUCTION: Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27763918/verification-of-nasopharyngeal-temperature-probes-they-are-not-always-where-you-think-they-are
#14
André van Zundert, Kerstin Wyssusek, Vernon Vivian
No abstract text is available yet for this article.
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27746312/als-new-molecular-mechanisms-and-emerging-therapeutic-targets
#15
EDITORIAL
Brigitte van Zundert
No abstract text is available yet for this article.
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27689934/epigenetic-signatures-at-the-runx2-p1-and-sp7-gene-promoters-control-osteogenic-lineage-commitment-of-umbilical-cord-derived-mesenchymal-stem-cells
#16
Hugo Sepulveda, Rodrigo Aguilar, Catalina P Prieto, Francisco Bustos, Sócrates Aedo, José Lattus, Brigitte van Zundert, Veronica Palma, Martin Montecino
Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent stem cells for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion are poorly understood. Particularly, epigenetic control operating at the promoter regions of the two master regulators of the osteogenic program, RUNX2/P57 and SP7 has not yet been described in WJ-MSCs. Via quantitative PCR profiling and chromatin immunoprecipitation (ChIP) studies, here we analyze the ability of WJ-MSCs to engage osteoblast lineage...
September 30, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27663451/a-randomized-comparison-between-intravenous-and-perineural-dexamethasone-for-ultrasound-guided-axillary-block
#17
RANDOMIZED CONTROLLED TRIAL
Julian Aliste, Prangmalee Leurcharusmee, Phatthanaphol Engsusophon, Aida Gordon, Giuliano Michelagnoli, Chonticha Sriparkdee, Worakamol Tiyaprasertkul, Dana Q Tran, Tom C R V Van Zundert, Roderick J Finlayson, De Q H Tran
BACKGROUND: This randomized double-blinded trial compared the effect of intravenous and perineural dexamethasone (8 mg) on the duration of motor block for ultrasound (US)-guided axillary brachial plexus block (AXB). METHODS: Patients undergoing upper limb surgery with US-guided AXB were randomly allocated to receive preservative-free dexamethasone (8 mg) via intravenous (n = 75) or perineural (n = 75) administration. The local anesthetic agent, 1% lidocaine -0...
January 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27608347/anaesthetists-experiences-with-the-early-labour-epidural-recommendation-for-obese-parturients-a-qualitative-study
#18
V A Eley, L K Callaway, A A J van Zundert, J Lipman, C Gallois
Caring for obese pregnant women presents challenges for all medical professionals. Despite a lack of supporting evidence, expert opinion and international guidelines suggest early labour epidural insertion for obese women. Anecdotally this is not supported by all anaesthetists. This qualitative study explored the experiences of anaesthetists regarding early epidural analgesia in obese parturients, to answer the research question: Are anaesthetists consistent in how they apply early epidural analgesia in obese parturients? Personal in-depth interviews with 42 specialist anaesthetists working in south-east Queensland, Australia, were completed between February and April, 2015...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27608338/does-objective-measurement-of-tracheal-tube-cuff-pressures-minimise-adverse-effects-and-maintain-accurate-cuff-pressures-a-systematic-review-and-meta-analysis
#19
C A Hockey, A A J van Zundert, J D Paratz
Correct inflation pressures of the tracheal cuff are recommended to ensure adequate ventilation and prevent aspiration and adverse events. However there are conflicting views on which measurement to employ. The aim of this review was to examine whether adjustment of cuff pressure guided by objective measurement, compared with subjective measurement or observation of the pressure value alone, was able to prevent patient-related adverse effects and maintain accurate cuff pressures. A search of PubMed, Web of Science, Embase, CINAHL and ScienceDirect was conducted using keywords 'cuff pressure' and 'measure*' and related synonyms...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27608337/anaesthetic-management-of-obese-parturients-what-is-the-evidence-supporting-practice-guidelines
#20
V A Eley, A A J van Zundert, J Lipman, L K Callaway
Increasing rates of obesity in western populations present management difficulties for clinicians caring for obese pregnant women. Various governing bodies have published clinical guidelines for the care of obese parturients. These guidelines refer to two components of anaesthetic care: anaesthetic consultation in the antenatal period for women with a body mass index (BMI) ≥ 40 kg/m(2) and the provision of early epidural analgesia in labour. These recommendations are based on the increased incidence of obstetric complications and the predicted risks and difficulties in providing anaesthetic care...
September 2016: Anaesthesia and Intensive Care
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