Alexis Martinez, Cristian M Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M Kamiński, Nibaldo C Inestrosa, Brigitte van Zundert, Gonzalo I Cancino, Andrés E Dulcey, Silvana Zanlungo, Juan J Marugan, Claudio Hetz, Douglas R Green, Alejandra R Alvarez
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged, cells can undergo cell death, in part due to oxidative stress and mitochondrial fragmentation. Here, we report that endoplasmic reticulum stress activates c-Abl tyrosine kinase, inducing its translocation to mitochondria. We found that endoplasmic reticulum stress-activated c-Abl interacts with and phosphorylates the mitochondrial fusion protein MFN2, resulting in mitochondrial fragmentation and apoptosis...
November 16, 2023: Antioxidants (Basel, Switzerland)