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https://www.readbyqxmd.com/read/28327657/dynasore-impairs-vegfr2-signalling-in-an-endocytosis-independent-manner
#1
Dimitris Basagiannis, Sofia Zografou, Katerina Galanopoulou, Savvas Christoforidis
VEGFR2 is a critical angiogenic receptor playing a key role in vascular homeostasis. Upon activation by VEGF, VEGFR2 becomes endocytosed. Internalisation of VEGFR2 is facilitated, in part, through clathrin mediated endocytosis (CME), the role of which in VEGFR2 function is debated. Here, we confirm the contribution of CME in VEGFR2 uptake. However, curiously, we find that different approaches of inhibition of CME exert contradictory effects on VEGF signalling; knockdown of clathrin, or of dynamin, or overexpression of dynamin K44A, do not affect VEGF-induced phosphorylation of ERK1/2, while dynasore causes strong inhibition...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323132/direct-participation-of-dna-in-the-formation-of-singlet-oxygen-and-base-damage-under-uva-irradiation
#2
Teiti Yagura, André Passaglia Schuch, Camila Carrião Machado Garcia, Clarissa Ribeiro Reily Rocha, Natália Cestari Moreno, José Pedro Friedmann Angeli, Davi Mendes, Divinomar Severino, Angelica Bianchini Sanchez, Paolo Di Mascio, Marisa Helena Gennari de Medeiros, Carlos Frederico Martins Menck
UVA light is hardly absorbed by the DNA molecule, but recent works point to a direct mechanism of DNA lesion by these wavelengths. UVA light also excite endogenous chromophores, which causes DNA damage through ROS. In this study, DNA samples were irradiated with UVA light in different conditions to investigate possible mechanisms involved in the induction of DNA damage. The different types of DNA lesions formed after irradiation were determined through the use of endonucleases, which recognize and cleave sites containing oxidized bases and cyclobutane pyrimidine dimers (CPDs), as well as through antibody recognition...
March 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28317880/antidromic-rectifying-gap-junctions-amplify-chemical-transmission-at-functionally-mixed-electrical-chemical-synapses
#3
Ping Liu, Bojun Chen, Roger Mailler, Zhao-Wen Wang
Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By studying chemical and electrical synapses between premotor interneurons (AVA) and downstream motor neurons (A-MNs) in the Caenorhabditis elegans escape circuit, we found that disrupting either the chemical or electrical synapses causes defective escape response...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28295566/concomitant-confluent-and-reticulated-papillomatosis-and-acanthosis-nigricans-in-an-obese-girl-with-insulin-resistance-successfully-treated-with-oral-minocycline-case-report-and-published-work-review
#4
Takeshi Fukumoto, Takeshi Kozaru, Masanobu Sakaguchi, Masahiro Oka
Concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) is rare. We present a case of concomitant CRP and obesity-associated AN in a 12-year-old obese Japanese girl. Curiously, oral minocycline therapy, which has been shown to be effective for CRP, was effective against both CRP and AN. Possible mechanisms by which minocycline could have improved skin lesions of CRP and obesity-associated AN are discussed. In addition, reports of concomitant CRP and obesity-associated AN are reviewed...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28295017/antimicrobial-peptide-gramicidin-s-is-accumulated-in-granules-of-producer-cells-for-storage-of-bacterial-phosphagens
#5
Marina Berditsch, Mareike Trapp, Sergii Afonin, Christian Weber, Julia Misiewicz, Joana Turkson, Anne S Ulrich
Many antimicrobial peptides are synthesized non-ribosomally in bacteria, but little is known about their subcellular route of biosynthesis, their mode of intracellular accumulation, or their role in the physiology of the producer cells. Here, we present a comprehensive view on the biosynthesis of gramicidin S (GS) in Aneurinibacillus migulanus, having observed a peripheral membrane localization of its synthetases. The peptide gets accumulated in nano-globules, which mature by fusion into larger granules and end up within vacuolar structures...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290742/patients-beliefs-about-the-causes-of-myomas-a-pilot-study-from-a-large-european-city
#6
Matthias David, Miriam Alpheus, Heribert Kentenich
INTRODUCTION: Patients usually develop subjective concepts about their illness, which then influences their further health behaviors and treatment decisions. This study aimed to evaluate several possible patient beliefs about the causal factors of illness, in a large sample of women seeking treatment for myomas. METHODS: From November 2011 to October 2013, all patients at a specialized myoma clinic in a large European city were surveyed about their beliefs about the causes of myomas...
March 14, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28288469/individual-risk-and-prevention-of-complications-doctors-advice-to-persons-wishing-a-new-tattoo
#7
Jørgen Serup
Doctors who are consulted about health and tattoo risks have an important role in the prevention of an individual's tattoo complications. Tattooing is a tremendous exposure of the human body to needle operation, particles, and chemicals. The risk is related to a person's health condition, level of insight, decision-making, and to the operation of tattooing, tattoo inks and utensils, tattoo parlour, and the aftercare. Tattooing is painful minor surgery performed without anesthesia. It can be associated with syncope...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28286687/lipomatous-extensively-vacuolated-ependymoma-with-signet-ring-cell-like-appearance-analysis-of-a-case-with-extensive-literature-review
#8
Miguel Fdo Salazar, Martha Lilia Tena-Suck, Alma Ortiz-Plata, Citlaltepetl Salinas-Lara, Daniel Rembao-Bojórquez
"Lipomatous" and "extensively vacuolated" are descriptive captions that have been used to portray a curious subset of ependymomas distinctively bearing cells with a large vacuole pushing the nucleus to the periphery and, thus, simulating a signet-ring cell appearance. Here, we would like to report the first ependymoma of this kind in a Latin American institution. A 16-year-old boy experienced cephalea during three months. Magnetic resonance imaging scans showed a left paraventricular tumour which corresponded to anaplastic ependymoma...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28274686/curious-bivalves-systematic-utility-and-unusual-properties-of-anomalodesmatan-mitochondrial-genomes
#9
S T Williams, P G Foster, C Hughes, E M Harper, J D Taylor, D T J Littlewood, P Dyal, K P Hopkins, A G Briscoe
Mitogenomic trees for Bivalvia have proved problematic in the past, but several highly divergent lineages were missing from these analyses and increased representation of these groups may yet improve resolution. Here, we add seven new sequences from the Anomalodesmata and one unidentified semelid species (Bryopa lata, Euciroa cf. queenslandica, Laternula elliptica, Laternula truncata, Lyonsia norwegica, Myadora brevis, Tropidomya abbreviata, "Abra" sp.). We show that relationships in a mitogenomic tree for the Class are improved by the addition of seven anomalodesmatans from this highly divergent clade, but are still not completely consistent with relationships recovered in studies of nuclear genes...
March 6, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28268839/an-end-to-end-secure-cbir-over-encrypted-medical-database
#10
Reda Bellafqira, Gouenou Coatrieux, Dalel Bouslimi, Gwenole Quellec
In this paper, we propose a new secure content based image retrieval (SCBIR) system adapted to the cloud framework. This solution allows a physician to retrieve images of similar content within an outsourced and encrypted image database, without decrypting them. Contrarily to actual CBIR approaches in the encrypted domain, the originality of the proposed scheme stands on the fact that the features extracted from the encrypted images are themselves encrypted. This is achieved by means of homomorphic encryption and two non-colluding servers, we however both consider as honest but curious...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28257432/alternate-splicing-of-transcripts-shape-macrophage-response-to-mycobacterium-tuberculosis-infection
#11
Haroon Kalam, Mary F Fontana, Dhiraj Kumar
Transcriptional reprogramming of macrophages upon Mycobacterium tuberculosis (Mtb) infection is widely studied; however, the significance of alternate splicing (AS) in shaping cellular responses to mycobacterial infections is not yet appreciated. Alternate splicing can influence transcript stability or structure, function and localization of corresponding proteins thereby altering protein stoichiometry and physiological consequences. Using comprehensive analysis of a time-series RNA-seq data obtained from human macrophages infected with virulent or avirulent strains of Mtb, we show extensive remodeling of alternate splicing in macrophage transcriptome...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28241484/mrna-quantification-of-nipbl-isoforms-a-and-b-in-adult-and-fetal-human-tissues-and-a-potentially-pathological-variant-affecting-only-isoform-a-in-two-patients-with-cornelia-de-lange-syndrome
#12
Beatriz Puisac, María-Esperanza Teresa-Rodrigo, María Hernández-Marcos, Carolina Baquero-Montoya, María-Concepción Gil-Rodríguez, Torkild Visnes, Christopher Bot, Paulino Gómez-Puertas, Frank J Kaiser, Feliciano J Ramos, Lena Ström, Juan Pié
Cornelia de Lange syndrome (CdLS) is a congenital developmental disorder characterized by craniofacial dysmorphia, growth retardation, limb malformations, and intellectual disability. Approximately 60% of patients with CdLS carry a recognizable pathological variant in the NIPBL gene, of which two isoforms, A and B, have been identified, and which only differ in the C-terminal segment. In this work, we describe the distribution pattern of the isoforms A and B mRNAs in tissues of adult and fetal origin, by qPCR (quantitative polymerase chain reaction)...
February 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28237383/the-curious-case-of-a-cardiac-tamponade-in-the-hypertensive-patient-presenting-as-abdominal-fullness
#13
William Li, Rogin Subedi, Bhaskara Madhira
Cardiac tamponade is a medical emergency consisting of an accumulation of fluid in the pericardial space which is rapidly progressing and fatal. Because cardiac tamponade is ultimately a clinical diagnosis, mindful consideration for atypical presentations is essential for the reduction of mortality in the acute setting. Our patient was a 77year-old female admitted after presenting with general malaise, weakness, somnolence, altered mental status and urinary incontinence found to have CML (chronic myeloid leukemia) on confirmatory bone marrow biopsy after suspicions arose from a leukocytosis of 34,000 cells per mcL with 85% neutrophils and elevated blasts (8%)...
January 19, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28231704/genetic-correlations-between-behavioural-responses-and-performance-traits-in-laying-hens
#14
Iwona Rozempolska-Rucińska, Grzegorz Zięba, Lucyna Kibała, Tomasz Paweł Próchniak, Marek Łukaszewicz
The aim of the study was to evaluate genetic correlations between the behavioural profile and performance in laying hens as an indirect answer to the question whether the observed behavioural responses are associated with increased levels of stress in these birds. The assessment of birds' temperament was carried out using the Novel Objects Test. The behavioural test was conducted in two successive generations comprising 9483 Rhode Island White birds (approx. 4700 individuals per generation) and 4326 Rhode Island Red birds (approx...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28227037/an-end-to-end-secure-cbir-over-encrypted-medical-database
#15
Reda Bellafqira, Gouenou Coatrieux, Dalel Bouslimi, Gwenole Quellec, Reda Bellafqira, Gouenou Coatrieux, Dalel Bouslimi, Gwenole Quellec, Gwenole Quellec, Reda Bellafqira, Dalel Bouslimi, Gouenou Coatrieux
In this paper, we propose a new secure content based image retrieval (SCBIR) system adapted to the cloud framework. This solution allows a physician to retrieve images of similar content within an outsourced and encrypted image database, without decrypting them. Contrarily to actual CBIR approaches in the encrypted domain, the originality of the proposed scheme stands on the fact that the features extracted from the encrypted images are themselves encrypted. This is achieved by means of homomorphic encryption and two non-colluding servers, we however both consider as honest but curious...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223501/biosynthetic-pathway-of-aliphatic-formates-via-a-baeyer-villiger-oxidation-in-mechanism-present-in-astigmatid-mites
#16
Nobuhiro Shimizu, Daisuke Sakata, Eric A Schmelz, Naoki Mori, Yasumasa Kuwahara
Astigmatid mites depend on bioactive glandular secretions, pheromones, and defensive agents to mediate intra- and interspecies interactions. Aliphatic formates, such as (Z,Z)-8,11-heptadecadienyl formate (8,11-F17) and (Z)-8-heptadecenyl formate (8-F17), are rarely encountered natural products that are abundant in Sancassania sp. Sasagawa (Acari: Acaridae) mite secretions. Linoleic acid and oleic acid are predicted as key intermediates in the synthesis of the closely related aliphatic formates. To gain insight in this biosynthetic pathway, acarid mite feeding experiments were conducted using (13)C-labeled precursors to precisely track incorporation...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28215044/developing-caring-conversations-in-care-homes-an-appreciative-inquiry
#17
Belinda Dewar, Tamsin MacBride
Relationship-centred practice is key to delivering quality care in care homes. Evidence is strong about the centrality of human interaction in developing relationships that promote dignity and compassion. The Caring Conversations framework is a framework for delivering compassionate care based on human interactions that was developed in the acute healthcare setting. The key attributes are: be courageous, connect emotionally, be curious, consider other perspectives, collaborate, compromise and celebrate. This paper reports on a study to explore its relevance to the care home setting and the development of an educational intervention, based on the framework, to enhance development of human interaction...
February 19, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28212816/social-science-s-curious-war-with-pop-culture-and-how-it-was-lost-the-media-violence-debate-and-the-risks-it-holds-for-social-science
#18
REVIEW
Christopher J Ferguson, Eugene Beresin
For nearly half a century, psychologists, pediatricians and psychiatrists have studied the potential impact of media violence on aggression and societal violence, particularly among youth. Despite hundreds of studies, scholars have failed to find consensus on potential effects. Nonetheless, professional organizations such as the American Academy of Pediatrics and American Psychological Association have released policy statements conclusively linking violent media to societal concerns. In reaction, some scholars have accused these professional groups of distorting evidence and failing to inform the public of the inconsistent nature of studies in this field...
February 14, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28198489/negative-effects-of-divalent-mineral-cations-on-the-bioaccessibility-of-carotenoids-from-plant-food-matrices-and-related-physical-properties-of-gastro-intestinal-fluids
#19
Joana Corte-Real, Marie Bertucci, Christos Soukoulis, Charles Desmarchelier, Patrick Borel, Elke Richling, Lucien Hoffmann, Torsten Bohn
Carotenoid intake and tissue levels have been frequently associated with reduced risk of chronic diseases. However, their bioavailability is low and influenced by many dietary related parameters. Divalent mineral cations have been suggested to interfere with carotenoid digestion and to hamper micellarization, a prerequisite for their uptake, via complexation of bile salts and precipitation of fatty acids. In the present investigation, we have evaluated the effects of increasing concentrations of magnesium (0-300 mg L(-1)), calcium (0-1500 mg L(-1)), zinc (0-200 mg L(-1)), and sodium (0-1500 mg L(-1); control monovalent cation), on carotenoid bioaccessibility from frequently consumed food items rich in carotenoids (tomato juice, carrot juice, apricot nectar, spinach and field salad), following simulated gastro-intestinal digestion...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28191472/suppression-of-excessive-histone-deacetylases-activity-in-diabetic-hearts-attenuates-myocardial-ischemia-reperfusion-injury-via-mitochondria-apoptosis-pathway
#20
Yang Wu, Yan Leng, Qingtao Meng, Rui Xue, Bo Zhao, Liying Zhan, Zhongyuan Xia
Background. Histone deacetylases (HDACs) play a pivotal role in signaling modification and gene transcriptional regulation that are essential for cardiovascular pathophysiology. Diabetic hearts with higher HDACs activity were more vulnerable to myocardial ischemia/reperfusion (MI/R) injury compared with nondiabetic hearts. We are curious about whether suppression of excessive HDACs activity in diabetic heart protects against MI/R injury. Methods. Diabetic rats were subjected to 45 min of ischemia, followed by 3 h of reperfusion...
2017: Journal of Diabetes Research
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