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https://www.readbyqxmd.com/read/29342277/finding-nemo-hybrid-assembly-with-oxford-nanopore-and-illumina-reads-greatly-improves-the-clownfish-amphiprion-ocellaris-genome-assembly
#1
Mun Hua Tan, Christopher M Austin, Michael P Hammer, Yin Peng Lee, Laurence J Croft, Han Ming Gan
Background: Some of the most widely recognised coral-reef fishes are clownfish or anemonefishes, members of the family Pomacentridae (subfamily: Amphiprioninae). They are popular aquarium species due to their bright colours, adaptability to captivity and fascinating behavior. Their breeding biology (sequential hermaphrodites) and symbiotic mutualism with sea anemones have attracted much scientific interest. Moreover, there are some curious geographic-based phenotypes which warrant investigation...
January 12, 2018: GigaScience
https://www.readbyqxmd.com/read/29324878/the-curious-case-of-apobec3-activation-by-cancer-associated-human-papillomaviruses
#2
Nicholas A Wallace, Karl Münger
No abstract text is available yet for this article.
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29315624/prenatal-alcohol-exposure-increases-histamine-h3-receptor-mediated-inhibition-of-glutamatergic-neurotransmission-in-rat-dentate-gyrus
#3
Rafael K Varaschin, Nyika A Allen, Martina J Rosenberg, C Fernando Valenzuela, Daniel D Savage
BACKGROUND: We have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine H3 receptor inverse agonist ABT-239. Curiously, ABT-239 did not enhance LTP or memory in control offspring. Here, we initiated an investigation of how PAE alters histaminergic neurotransmission in the dentate gyrus and other brain regions employing combined radiohistochemical and electrophysiological approaches in vitro to examine histamine H3 receptor number and function...
December 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29308275/the-number-of-genes-encoding-repeat-domain-containing-proteins-positively-correlates-with-genome-size-in-amoebal-giant-viruses
#4
Avi Shukla, Anirvan Chatterjee, Kiran Kondabagil
Curiously, in viruses, the virion volume appears to be predominantly driven by genome length rather than the number of proteins it encodes or geometric constraints. With their large genome and giant particle size, amoebal viruses (AVs) are ideally suited to study the relationship between genome and virion size and explore the role of genome plasticity in their evolutionary success. Different genomic regions of AVs exhibit distinct genealogies. Although the vertically transferred core genes and their functions are universally conserved across the nucleocytoplasmic large DNA virus (NCLDV) families and are essential for their replication, the horizontally acquired genes are variable across families and are lineage-specific...
January 2018: Virus Evolution
https://www.readbyqxmd.com/read/29306874/a-structurally-dynamic-n-terminal-region-drives-function-of-the-staphylococcal-peroxidase-inhibitor-spin
#5
Nienke W M de Jong, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Alvaro I Herrera, Om Prakash, Benjamin B Katz, Kevin G Leidal, William Nauseef, Kok van Kessel, Jos van Strijp, Brian V Geisbrecht
The heme-containing enzyme myeloperoxidase (MPO) is critical for optimal antimicrobial activity of human neutrophils. We recently discovered that the bacterium Staphylococcus aureus expresses a novel immune evasion protein, called SPIN, that binds tightly to MPO, inhibits MPO activity, and contributes to bacterial survival following phagocytosis. A co-crystal structure of SPIN bound to MPO suggested that SPIN blocks substrate access to the catalytic heme by inserting an N-terminal β-hairpin into the MPO active site channel...
January 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29305756/on-aneurysmal-rupture-and-rerupture
#6
Eelco F M Wijdicks
A warning leak is a curious phenomenon attributed to cerebral aneurysms. Once the leak occurs, it has been postulated it could lead to a more catastrophic rebleeding. The designation "warning leak" trickled into neurosurgery vocabulary as early as the 1950s. The phenomenon has been poorly understood and characterized, but its presence spurs emergency physicians and neurointensivists to take action to secure the aneurysm. Rapid treatment of a recently discovered aneurysm is now commonplace, but it has not always been so...
January 5, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29301322/search-methods-used-to-locate-missing-cats-and-locations-where-missing-cats-are-found
#7
Liyan Huang, Marcia Coradini, Jacquie Rand, John Morton, Kat Albrecht, Brigid Wasson, Danielle Robertson
Missing pet cats are often not found by their owners, with many being euthanized at shelters. This study aimed to describe times that lost cats were missing for, search methods associated with their recovery, locations where found and distances travelled. A retrospective case series was conducted where self-selected participants whose cat had gone missing provided data in an online questionnaire. Of the 1210 study cats, only 61% were found within one year, with 34% recovered alive by the owner within 7 days...
January 2, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29298419/oxygen-sensitive-remodeling-of-central-carbon-metabolism-by-archaic-eif5b
#8
J J David Ho, Nathan C Balukoff, Grissel Cervantes, Petrice D Malcolm, Jonathan R Krieger, Stephen Lee
The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of IF2, an ancient translation factor that enables initiator methionine-tRNAiMet (met-tRNAiMet) loading on prokaryotic ribosomes. While it can be traced back to the last universal common ancestor, eIF5B is curiously dispensable in modern aerobic yeast and mammalian cells. Here, we show that eIF5B is an essential element of the cellular hypoxic cap-dependent protein synthesis machinery. System-wide interrogation of dynamic translation machineries by MATRIX (mass spectrometry analysis of active translation factors using ribosome density fractionation and isotopic labeling experiments) demonstrated augmented eIF5B activity in hypoxic translating ribosomes...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29287946/what-we-do-and-do-not-know-about-women-and-kidney-diseases-questions-unanswered-and-answers-unquestioned-reflection-on-world-kidney-day-and-international-woman-s-day
#9
Giorgina B Piccoli, Mona Alrukhaimi, Zhi-Hong Liu, Elena Zakharova, Adeera Levin
Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly...
December 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29286722/extensional-strain-hardening-induced-by-%C3%AF-%C3%AF-interactions-in-barely-entangled-polymer-chains-the-curious-case-of-poly-4-vinylbiphenyl
#10
Carlos R López-Barrón, Huaxing Zhou
Aromatic π-π interactions between phenyl groups of adjacent chains in poly(4-vinylbiphenyl) (PVBP) have profound effects on the dynamics of this polymer. We report two unexpected nonlinear viscoelastic responses of PVBP when subjected to uniaxial flow. One is the unprecedented observation of extensional strain hardening (SH) in a barely entangled polymer melt. An even more intriguing finding is that SH of lightly (or even barely) entangled melts occurs at strain rates one order of magnitude below the coil-stretch transition predicted by Rouse theory (ϵ[over ˙]_{H}=0...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29284166/functional-screening-tests-interrelationships-and-ability-to-predict-vertical-jump-performance
#11
Irineu Loturco, Lucas Adriano Pereira, Ronaldo Kobal, Cesar Cavinato Cal Abad, William Komatsu, Ronaldo Cunha, Gustavo Arliani, Benno Ejnisman, Alberto de Castro Pochini, Fábio Yuzo Nakamura, Moises Cohen
There are several methods used in sports science to identify asymmetries in athletes, given their purported relevance to injury prevention and performance optimization. We aimed to verify whether asymmetries provided by isokinetic assessments, jump tests, and tensiomyography (TMG) are associated with each other, and whether their respective functional indices are related to jumping ability. TMG parameters, unilateral and bilateral squat-jump (SJ) and countermovement-jump (CMJ) performances, and peak torque in knee-extension and flexion with angular velocities of 60o/s and 300o/s for twenty-four soccer players were retained for analyses...
December 28, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29283187/cell-size-control-via-an-unstable-accumulating-activator-and-the-phenomenon-of-excess-mitotic-delay
#12
Nicholas Rhind
Unstable Accumulating Activator models for cellular size control propose an activator that accumulates in a size-dependent manner and triggers cell cycle progression once it has reached a certain threshold. Having a short half life makes such an activator responsive to changes in cell size and makes specific predictions for how cells respond to perturbation. In particular, it explains the curious phenomenon of excess mitotic delay. Excess mitotic delay, first observed in Tetrahymena in the '50s, is a phenomenon in which a pulse of protein synthesis inhibition causes a delay in mitotic entry that is longer than the pulse and that gets longer the later in the cell cycle the pulse is delivered...
December 28, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29275798/a-curious-oversight-in-acupuncture-research
#13
Fletcher Kovich
Common phenomena central to acupuncture have been overlooked by previous hypotheses on how acupuncture works, with the result that the hypotheses are unable to account for acupuncture's effects. This article describes the main features overlooked and suggests how these might be investigated in future acupuncture research.
December 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29259311/the-impact-of-elevated-c-reactive-protein-level-on-the-prognosis-for-oro-hypopharynx-cancer-patients-treated-with-radiotherapy
#14
Atsuto Katano, Wataru Takahashi, Hideomi Yamashita, Kentaro Yamamoto, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Osamu Abe, Keiichi Nakagawa
The purpose of this study was to investigate an association between the prognosis for oro-hypopharynx squamous cell carcinoma treated with radiation therapy and the pre-therapeutic level of C-reactive protein (CRP). Patient with oro-hypopharyngeal squamous cell carcinoma who underwent definitive radiotherapy in our institution from January 2002 to August 2016 were enrolled. The patient were divided into elevated CRP (over 0.3 mg/dl) group and normal CRP groups, according to pre-treatment serum levels. There were 276 evaluable patients, and the median follow up was 41 months, ranging from 2 to 171 months...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251738/nm23-proteins-innocent-bystanders-or-local-energy-boosters-for-cftr
#15
Richmond Muimo, Hani Mm Alothaid, Anil Mehta
NM23 proteins NDPK-A and -B bind to the cystic fibrosis (CF) protein CFTR in different ways from kinases such as PKA, CK2 and AMPK or linkers to cell calcium such as calmodulin and annexins. NDPK-A (not -B) interacts with CFTR through reciprocal AMPK binding/control, whereas NDPK-B (not -A) binds directly to CFTR. NDPK-B can activate G proteins without ligand-receptor coupling, so perhaps NDPK-B's binding influences energy supply local to a nucleotide-binding site (NBD1) needed for CFTR to function. Curiously, CFTR (ABC-C7) is a member of the ATP-binding cassette (ABC) protein family that does not obey 'clan rules'; CFTR channels anions and is not a pump, regulates disparate processes, is itself regulated by multiple means and is so pleiotropic that it acts as a hub that orchestrates calcium signaling through its consorts such as calmodulin/annexins...
December 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29249564/synchronous-tumours-of-the-female-reproductive-tract
#16
REVIEW
C Blake Gilks, Friedrich Kommoss
Many ovarian endometrioid carcinomas present with concurrent endometrial carcinoma, and these organ-confined, low-grade synchronous endometrial and ovarian tumours consistently behave as independent primary tumours, rather than a single advanced-stage carcinoma; they are associated with a very favourable prognosis and there is no need for adjuvant treatment. This phenomenon of synchronous tumours involving two or more sites within the female reproductive tract is well recognised, occurring in 1-2% of cases...
December 14, 2017: Pathology
https://www.readbyqxmd.com/read/29243382/bringing-the-bottom-billion-into-basic-literacy-how-we-can-and-why-we-must
#17
Stephanie Gottwald, Robin Morris, Maryanne Wolf, Tinsley Galyean
Close to one billion people in the world do not have basic literacy skills. A key challenge is reaching children in the midst of circumstances that make a traditional school-based approach impractical. This chapter will describe a cross-disciplinary, mobile technology approach to literacy education. The Curious Learning approach distributes research-based, English literacy content on mobile devices to children without access to an adequate school. The software platform is equipped with data collection tools to measure usage patterns and literacy outcomes...
December 2017: New Directions for Child and Adolescent Development
https://www.readbyqxmd.com/read/29232317/attitude-of-nursing-students-toward-scientific-research-a-cross-sectional-study-in-turkey
#18
Seher Ünver, Remziye Semerci, Zeynep Kizilcik Özkan, Ilker Avcibaşi
BACKGROUND: Nursing, a social applied science, is a dynamic profession. Professional nurses must be curious, investigative, and open to learning as well as practice critical and analytic thinking to sustain their professionalism. PURPOSE: The aim of this study was to determine the attitudes of nursing students toward scientific research. METHODS: A descriptive and cross-sectional study design was used. This study was conducted at a nursing department of a university in Turkey...
December 9, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29213024/-a-refractory-case-of-ulcerative-colitis-developed-after-the-cessation-smoking-achieved-clinical-and-endoscopic-remission-after-resuming-smoking
#19
Tetsuro Hamamoto, Masashi Ohtani, Eiji Matsumoto, Tatsuaki Hori, Ichiro Tsuruhara, Kazuo Yashima, Hajime Isomoto
A 42-year-old man, who had stopped smoking almost one year ago, visited our hospital for hematochezia. He was diagnosed as having ulcerative colitis and was prescribed 5-amino salicylic acid and corticosteroids, which led to the remission of his disease. However, the disease relapsed after sufficient continuous corticosteroids administration and persisted despite 5-amino salicylic acid administration and intensive treatment with corticosteroids, immune modulators, leukocyte apheresis, and anti-TNF-α antibodies...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29209354/how-glucosinolates-affect-generalist-lepidopteran-larvae-growth-development-and-glucosinolate-metabolism
#20
Verena Jeschke, Emily E Kearney, Katharina Schramm, Grit Kunert, Anton Shekhov, Jonathan Gershenzon, Daniel G Vassão
Multiple lepidopteran larvae feed successfully on plants containing glucosinolates despite the diverse array of toxic and deterrent breakdown products, such as isothiocyanates (ITCs), formed upon plant damage. While much is known about how specialist lepidopterans metabolize and tolerate glucosinolates, there is little information about the metabolic fate of these plant defense compounds in specialized herbivores. Employing 13C- and 14C-labeled 4-methylsulfinylbutyl glucosinolate (glucoraphanin), we identified and quantified the major detoxification products of glucosinolates and ITCs in selected specialized and generalist larvae...
2017: Frontiers in Plant Science
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