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https://www.readbyqxmd.com/read/27922011/detecting-stoichiometry-of-macromolecular-complexes-in-live-cells-using-fret
#1
Manu Ben-Johny, Daniel N Yue, David T Yue
The stoichiometry of macromolecular interactions is fundamental to cellular signalling yet challenging to detect from living cells. Fluorescence resonance energy transfer (FRET) is a powerful phenomenon for characterizing close-range interactions whereby a donor fluorophore transfers energy to a closely juxtaposed acceptor. Recognizing that FRET measured from the acceptor's perspective reports a related but distinct quantity versus the donor, we utilize the ratiometric comparison of the two to obtain the stoichiometry of a complex...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27920779/functional-versatility-of-agy-serine-codons-in-immunoglobulin-variable-region-genes
#2
Thiago Detanico, Matthew Phillips, Lawrence J Wysocki
In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are far more abundant in complementarity-determining regions (CDRs) of IgV-region genes than expected for random codon use or from species-specific codon frequency data. CDR AGY codons are also more abundant than TCN Ser codons. We show that these trends hold even in cartilaginous fishes...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27917731/the-measurement-of-intelligence-in-the-xxi-century-using-video-games
#3
M A Quiroga, F J Román, J De La Fuente, J Privado, R Colom
This paper reviews the use of video games for measuring intelligence differences and reports two studies analyzing the relationship between intelligence and performance on a leisure video game. In the first study, the main focus was to design an Intelligence Test using puzzles from the video game. Forty-seven young participants played "Professor Layton and the curious village"® for a maximum of 15 hours and completed a set of intelligence standardized tests. Results show that the time required for completing the game interacts with intelligence differences: the higher the intelligence, the lower the time (d = ...
December 5, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27917541/fish-pollutants-mehg-and-aroclor-cause-permanent-structural-damage-in-male-gonad-and-kidney-after-prepubertal-exposure
#4
Mariana S Garcia, Dulce Helena J Constantino, Ana P G Silva, Juliana E Perobelli
This study investigated whether or not prepubertal exposure to the fish contaminants methylmercury (MeHg) and the polychlorinated bisphenol Aroclor in low doses interferes with the histomorphometry of the testes, epididymis, liver and kidneys in rats. Wistar male rats, 21 days old, were allocated into the following: control (n = 17, received corn oil), MeHg (n = 17, received MeHg at 0.5 mg/kg/day), Aroclor (n = 17, received Aroclor at 1.0 mg/kg/day), low mix (n = 18, received MeHg at 0.05 mg/kg/day and Aroclor at 0...
December 5, 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27917523/a-curious-case-of-blinking-bottom
#5
H Rajgopal Bala, C C Wong, S J Robertson
No abstract text is available yet for this article.
December 5, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27914476/lidocaine-relaxation-in-isolated-rat-aortic-rings-is-enhanced-by-endothelial-removal-possible-role-of-kv-katp-channels-and-a2a-receptor-crosstalk
#6
Aryadi Arsyad, Geoffrey P Dobson
BACKGROUND: Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of ancillary properties. Our aim was to investigate lidocaine's vasoreactivity properties in intact versus denuded rat thoracic aortic rings, and the effect of inhibitors of nitric oxide (NO), prostenoids, voltage-dependent Kv and KATP channels, membrane Na(+)/K(+) pump, and A2a and A2b receptors. METHODS: Aortic rings were harvested from adult male Sprague Dawley rats and equilibrated in an organ bath containing oxygenated, modified Krebs-Henseleit solution, pH 7...
December 3, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27908404/fluoride-affects-bone-repair-differently-in-mice-models-with-distinct-bone-densities
#7
Paula Kennerly Herrera, Andressa Pelissari Zambolin, Mileni da Silva Fernandes, Tânia Mary Cestari, Flávia Godoy Iano, Willian Fernando Zambuzzi, Marília Afonso Rabelo Buzalaf, Rodrigo Cardoso de Oliveira
We grouped mice [strains: C57BL/6J (n=32) and C3H/HeJ (n=32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50ppm of F for up to 28days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27890940/whatever-happened-to-formal-methods-for-security
#8
J Voas, K Schaffer
We asked 7 experts 7 questions to find out what has occurred recently in terms of applying formal methods (FM) to security-centric, cyber problems. We are continually reminded of the 1996 paper by Tony Hoare "How did Software Get So Reliable Without Proof?" [1] In that vein, how did we get so insecure with proof? Given daily press announcements concerning new malware, data breaches, and privacy loss, is FM still relevant or was it ever? Our experts answered with unique personal insights. We were curious as to whether this successful methodology in "safety-critical" has succeeded as well for today's "build it, hack it, patch it" mindset...
August 2016: Computer
https://www.readbyqxmd.com/read/27884588/colour-preference-between-adults-and-children-during-a-dental-treatment-session
#9
Magrur Kazak
BACKGROUND: It is evidently shown that colour has physical, psychological and sociological effects on human beings. There are many studies showing the effects of colours on brain activity. Colour preferences may change from childhood to adulthood and are significantly different in various age groups. The aim of this study was to evaluate the adults and children in their preference for mouthrinses in various colours under stress condition during a dental treatment session. METHODS: 240 adults and 263 children were included in the study...
November 21, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27875231/eshiver-lateral-force-feedback-on-fingertips-through-oscillatory-motion-of-an-electroadhesive-surface
#10
Joseph Mullenbach, Michael Peshkin, J Edward Colgate
We describe a new haptic force feedback device capable of creating lateral shear force on a bare fingertip - the eShiver. The eShiver creates a net lateral force from in-plane oscillatory motion of a surface synchronized with a "friction switch" based on Johnsen-Rahbek electroadhesion. Using an artificial finger, a maximum net lateral force of 300 mN is achieved at 55 Hz lateral oscillation frequency, and net force is shown to be a function of velocity and applied voltage, as well as the phase between them...
November 17, 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/27873759/the-curious-career-of-dr-monica-kidd
#11
David McDonald
No abstract text is available yet for this article.
November 21, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27870200/petter-karlberg-1919-2006-a-curious-scientist
#12
Ingemar Kjellmer, Göran Wennergren
No abstract text is available yet for this article.
December 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27863222/a-curious-case-of-molecular-kidnapping
#13
Dipayan Rudra, Jonathan R Warner
In this issue of Molecular Cell, Albert et al. (2016) demonstrate how the production of rRNA and ribosomal proteins is coordinated through a two-step response to stress that requires cross-talk between a dedicated transcription factor and a ribosome assembly factor.
November 17, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27862520/medullary-bone-in-fossils-function-evolution-and-significance-in-growth-curve-reconstructions-of-extinct-vertebrates
#14
Edina Prondvai
Medullary bone (MB) is a special endosteal tissue forming in the bones of female birds during egg-laying to serve as a labile calcium reservoir for building the hard eggshell. Therefore, the presence of MB reported in multiple non-avian dinosaurs is currently considered as evidence that those specimens were sexually mature females in their reproductive period. This interpretation has led to further inferences on species-specific growth strategies and related life history aspects of these extinct vertebrates...
November 18, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27859574/reintroduction-failure-is-common-among-adolescents-after-double-blind-placebo-controlled-food-challenges
#15
Å Strinnholm, A Winberg, L Hedman, E Rönmark, V Lindh
AIM: There has been a lack of research on adolescents who undergo double-blind placebo-controlled food challenges. The aim of this study was to investigate food allergic adolescents' experiences and consequences of double-blind placebo-controlled food challenges. METHODS: This qualitative, descriptive interview study included 17 adolescents aged 14-15 years with total elimination of cows' milk, hens' eggs or cod due to food allergies. The participants, who were initially identified from a large population-based cohort study, were interviewed 18 months after completing their challenges...
November 12, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27847843/proximity-of-vital-structures-to-the-clavicle-comparison-of-fractured-and-non-fractured-side
#16
Frans J Mulder, Jos J Mellema, David Ring
BACKGROUND: Previous anatomic and radiological studies have described the relationship of the clavicle to major neurovascular structures in healthy subjects. We were curious about this relationship in patients with a clavicle fracture and if it is different from non-fractured clavicles. METHODS: We retrospectively identified all patients with a clavicle fracture between July 2001 and October 2013 in two level 1 trauma centers. Patients aged 18 years or greater with an acute unilateral clavicle fracture and a chest CT scan in the supine position displaying both clavicles and the complete fracture were included...
October 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27831526/a-curious-case-of-reversible-tetany
#17
Pamela Musacchia, Jerussa Aita-Levy
No abstract text is available yet for this article.
November 8, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27826811/inducible-de-novo-biosynthesis-of-isoflavonoids-in-soybean-leaves-by-spodoptera-litura-derived-elicitors-tracer-techniques-aided-by-high-resolution-lcms
#18
Ryu Nakata, Yuki Kimura, Kenta Aoki, Naoko Yoshinaga, Masayoshi Teraishi, Yutaka Okumoto, Alisa Huffaker, Eric A Schmelz, Naoki Mori
Isoflavonoids are a characteristic family of natural products in legumes known to mediate a range of plant-biotic interactions. For example, in soybean (Glycine max: Fabaceae) multiple isoflavones are induced and accumulate in leaves following attack by Spodoptera litura (Lepidoptera: Noctuidae) larvae. To quantitatively examine patterns of activated de novo biosynthesis, soybean (Var. Enrei) leaves were treated with a combination of plant defense elicitors present in S. litura gut content extracts and L-α-[(13)C9, (15)N]phenylalanine as a traceable isoflavonoid precursor...
November 8, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27823585/association-of-diabetes-mellitus-with-presence-expansion-and-rupture-of-abdominal-aortic-aneurysm-curiouser-and-curiouser-cried-alice
#19
REVIEW
Hisato Takagi
Both coronary artery and peripheral artery disease are representative atherosclerotic diseases that are positively associated with presence of abdominal aortic aneurysm (AAA). Diabetes mellitus, which is one of major risk factors of coronary artery and peripheral artery diseases, however, has been curiously suggested to be negatively associated with AAA, despite the positive associations of coronary artery and peripheral artery diseases with presence of AAA. In the present article, we overviewed epidemiologic evidence (meta-analyses) regarding the associations of diabetes mellitus with presence, expansion, and rupture of AAA through a systematic literature search...
March 2016: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/27814989/a-curious-case-of-septic-shock
#20
Arjun Lakshman, Charanpreet Singh, Manphool Singhal, Sanjay Jain, Navneet Sharma, Savita Kumari, Subhash Varma
BACKGROUND: Takayasu arteritis, also known as "pulseless disease," causes proximal occlusion of the lumen of large arteries of the neck and arm, leading to impalpable pulses and "pseudohypotension." This may misdirect the management plan for a patient in the emergency setting if the presence of vascular occlusion is not previously known. CASE REPORT: We describe a young woman who presented to the emergency department (ED) with fever. On evaluation, she had shock, which was not responsive to a fluid bolus...
November 1, 2016: Journal of Emergency Medicine
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