keyword
MENU ▼
Read by QxMD icon Read
search

curious

keyword
https://www.readbyqxmd.com/read/28939801/cooperative-colloidal-self-assembly-of-metal-protein-superlattice-wires
#1
Ville Liljeström, Ari Ora, Jukka Hassinen, Heikki T Rekola, Nonappa, Maria Heilala, Ville Hynninen, Jussi J Joensuu, Robin H A Ras, Päivi Törmä, Olli Ikkala, Mauri A Kostiainen
Material properties depend critically on the packing and order of constituent units throughout length scales. Beyond classically explored molecular self-assembly, structure formation in the nanoparticle and colloidal length scales have recently been actively explored for new functions. Structure of colloidal assemblies depends strongly on the assembly process, and higher structural control can be reliably achieved only if the process is deterministic. Here we show that self-assembly of cationic spherical metal nanoparticles and anionic rod-like viruses yields well-defined binary superlattice wires...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28930676/localized-phosphorylation-of-a-kinesin-1-adaptor-by-a-capsid-associated-kinase-regulates-hiv-1-motility-and-uncoating
#2
Viacheslav Malikov, Mojgan H Naghavi
Although microtubule motors mediate intracellular virus transport, the underlying interactions and control mechanisms remain poorly defined. This is particularly true for HIV-1 cores, which undergo complex, interconnected processes of cytosolic transport, reverse transcription, and uncoating of the capsid shell. Although kinesins have been implicated in regulating these events, curiously, there are no direct kinesin-core interactions. We recently showed that the capsid-associated kinesin-1 adaptor protein, fasciculation and elongation protein zeta-1 (FEZ1), regulates HIV-1 trafficking...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28916774/the-mechano-sensing-role-of-the-unique-sh3-insertion-in-plakin-domains-revealed-by-molecular-dynamics-simulations
#3
Csaba Daday, Katra Kolšek, Frauke Gräter
The plakin family of proteins, important actors in cross-linking force-bearing structures in the cell, contain a curious SH3 domain insertion in their chain of spectrin repeats (SRs). While SH3 domains are known to mediate protein-protein interactions, here, its canonical binding site is autoinhibited by the preceding SR. Under force, however, this SH3 domain could be released, and possibly launch a signaling cascade. We performed large-scale force-probe molecular dynamics simulations, across two orders of magnitude of loading rates, to test this hypothesis, on two prominent members of the plakin family: desmoplakin and plectin, obligate proteins at desmosomes and hemidesmosomes, respectively...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28914189/a-hopeful-prospect-of-riociguat-as-a-soluble-guanylate-cyclase-stimulator-for-management-of-pressure-ulcers
#4
Soha Azadi, Hajar Ashrafi, Amir Azadi
Pressure ulcer remains as a common problem, especially developed in disabled patients and hence, subjected to continuous pressure for prolonged periods of time. Most of the studies investigating the preventive and therapeutic approaches have focused on wound cleansing, dressing and supportive strategies , as well as pharmacological therapy including zinc sulphate, vitamin A or phenytoin. Despite such efforts, pressure ulcer continues to impair the life quality and expectancy. Thus involving in the paradigm shift in biomedical studies, the recent ones focus on biological signaling pathways involving nitric oxide (NO)- soluble guanylatecyclase (sGC)- cyclic guanosine monophosphate (cGMP) contributing in vasodilation, reperfusion and oxygen delivery...
September 15, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28886145/application-of-a-whole-blood-mycobacterial-growth-inhibition-assay-to-study-immunity-against-mycobacterium-tuberculosis-in-a-high-tuberculosis-burden-population
#5
Richard Baguma, Adam Penn-Nicholson, Erica Smit, Mzwandile Erasmus, Jonathan Day, Lebohang Makhethe, Marwou de Kock, E Jane Hughes, Michele van Rooyen, Bernadette Pienaar, Lynnett Stone, Willem Hanekom, Michael J Brennan, Robert S Wallis, Mark Hatherill, Thomas J Scriba
The determinants of immunological protection against Mycobacterium tuberculosis (M.tb) infection in humans are not known. Mycobacterial growth inhibition assays have potential utility as in vitro surrogates of in vivo immunological control of M.tb. We evaluated a whole blood growth inhibition assay in a setting with high burden of TB and aimed to identify immune responses that correlate with control of mycobacterial growth. We hypothesized that individuals with underlying M.tb infection will exhibit greater M...
2017: PloS One
https://www.readbyqxmd.com/read/28877691/alternative-moth-eye-nanostructures-antireflective-properties-and-composition-of-dimpled-corneal-nanocoatings-in-silk-moth-ancestors
#6
Mikhail Kryuchkov, Jannis Lehmann, Jakob Schaab, Vsevolod Cherepanov, Artem Blagodatski, Manfred Fiebig, Vladimir L Katanaev
Moth-eye nanostructures are a well-known example of biological antireflective surfaces formed by pseudoregular arrays of nipples and are often used as a template for biomimetic materials. Here, we provide morphological characterization of corneal nanostructures of moths from the Bombycidae family, including strains of domesticated Bombyx mori silk-moth, its wild ancestor Bombyx mandarina, and a more distantly related Apatelodes torrefacta. We find high diversification of the nanostructures and strong antireflective properties they provide...
September 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28872834/the-curious-case-of-fluorination-of-conjugated-polymers-for-solar-cells
#7
Qianqian Zhang, Mary Allison Kelly, Nicole Bauer, Wei You
Organic solar cells (OSCs) have been a rising star in the field of renewable energy since the introduction of the bulk heterojunction (BHJ) in 1992. Recent advances have pushed the efficiencies of OSCs to over 13%, an impressive accomplishment via collaborative efforts in rational materials design and synthesis, careful device engineering, and fundamental understanding of device physics. Throughout these endeavors, several design principles for the conjugated donor polymers used in such solar cells have emerged, including optimizing the conjugated backbone with judicious selection of building blocks, side-chain engineering, and substituents...
September 5, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28870600/interleukin-10-enhanced-cd8-t-cell-activity-and-reduced-cd8-t-cell-apoptosis-in-patients-with-diffuse-large-b-cell-lymphoma
#8
Huiying Qiu, Xiaoxia Hu, Lei Gao, Li Chen, Jie Chen, Joanna Yuan, Chongmei Huang, Xiaoqian Xu, Jianmin Yang
The pleiotropic cytokine interleukin (IL)-10 is best characterized by its ability to downregulate inflammation and promote peripheral tolerance. On the other hand, IL-10 was also found to maintain the effector response of CD8(+) T cells and promote the expansion of tumor-resident CD8(+) T cells. In diffuse large B cell lymphoma (DLBCL), the role of IL-10 has been characterized in tumor cells but not in CD8(+) T cells. We found that CD8(+) T cells in DLBCL presented robust interferon (IFN)-γ expression early during TCR-activation but could not maintain this response later on, which was characterized by significantly lower CD8(+) T cell degranulation and higher apoptosis...
September 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28868492/unusual-endoscopic-removal-of-a-curious-foreign-body
#9
Ana Torres Oliveira, Nuno Almeida, Mónica Martins, Carlos Sofia
No abstract text is available yet for this article.
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28865528/neurologic-emergencies-on-computed-tomography-of-the-head
#10
Jed Hollingsworth, Mae Mae Mirabelli
The purpose of this article is to provide the reader, a seasoned radiologist, a budding resident, or a curious practitioner, the background necessary to accurately and swiftly interpret a head computed tomography in the emergency setting. At the very least, being able to generate a reasonable differential diagnosis is the aim and will be accomplished by describing not only features of classic neurologic emergencies but also the possible traps to which one may fall prey. Images will be used to illustrate cases, and the reader will be instructed when other imaging modalities may be required to clarify diagnoses...
August 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28863515/novel-tilt-curvature-coupling-in-lipid-membranes
#11
M Mert Terzi, Markus Deserno
On mesoscopic scales, lipid membranes are well described by continuum theories whose main ingredients are the curvature of a membrane's reference surface and the tilt of its lipid constituents. In particular, Hamm and Kozlov [Eur. Phys. J. E 3, 323 (2000)] have shown how to systematically derive such a tilt-curvature Hamiltonian based on the elementary assumption of a thin fluid elastic sheet experiencing internal lateral pre-stress. Performing a dimensional reduction, they not only derive the basic form of the effective surface Hamiltonian but also express its emergent elastic couplings as trans-membrane moments of lower-level material parameters...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28855980/pseudomonas-endocarditis-with-an-unstable-phenotype-the-challenges-of-isolate-characterization-and-carbapenem-stewardship-with-a-partial-review-of-the-literature
#12
Emil Lesho, Erik Snesrud, Yoon Kwak, Ana Ong, Rosslyn Maybank, Maryrose Laguio-Vila, Ann R Falsey, Mary Hinkle
BACKGROUND: Pseudomonas endocarditis is exceedingly rare, especially in patients without predisposing risks. We present such a case that included unexpected switches in antibacterial resistance profiles in two Pseudomonas aeruginosa (PA) strains with the same whole-genome sequence. The case also involved diagnostic and treatment challenges, such as issues with automated testing platforms, choosing the optimal aminoglycoside, minimizing unnecessary carbapenem exposure, and the need for faster, more informative laboratory tests...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28846031/parity-influences-the-demeanor-of-sows-in-group-housing
#13
Taya Clarke, John R Pluske, David W Miller, Teresa Collins, Trish Fleming
Across the globe, producers are moving from individual housing to group housing for sows during gestation. Producers typically group sows of a range of parities together, although the impacts are largely unknown. This study examined the behavioral expression at mixing for young, midparity, and older sows. Ten mixed-parity groups were filmed at mixing on a commercial piggery. One-minute clips were edited from continuous footage where focal sows of known parity could be identified, and scored for qualitative behavioral expression...
August 28, 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28843389/impact-factor-a-curious-and-capricious-metric
#14
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
August 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28838802/literature-based-discovery-models-methods-and-trends
#15
REVIEW
M S Sam Henry, Bridget T McInnes
OBJECTIVES: This paper provides an introduction and overview of literature based discovery (LBD) in the biomedical domain. It introduces the reader to modern and historical LBD models, key system components, evaluation methodologies, and current trends. After completion, the reader will be familiar with the challenges and methodologies of LBD. The reader will be capable of distinguishing between recent LBD systems and publications, and be capable of designing an LBD system for a specific application...
August 21, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28837085/consumption-of-energy-drinks-among-undergraduate-students-in-taiwan-related-factors-and-associations-with-substance-use
#16
Yen-Jung Chang, Ching-Yi Peng, Yu-Ching Lan
Background: This study aimed to investigate the consumption of energy drinks and associated factors among undergraduate students in Taiwan. Methods: Data came from a cross-sectional survey conducted in 2015. Eligible participants completed a self-administered questionnaire assessing use and perceptions of energy drinks, tobacco, alcohol, and betel nut. Results: Among 606 surveyed undergraduate students, 24.8% reported consuming energy drinks in the past 30 days. The major reasons for use included keeping alert at work (48...
August 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28835865/primitive-neuroectodermal-tumor-and-wegener-s-granulomatosis-of-the-kidney-a-curious-combination-of-two-rare-entities
#17
Rugvedita Parakh, Satyajeet Parakh, Maria Tretiakova
Wegener's granulomatosis (WG) is characterized by necrotizing polyangiitis involving the respiratory tract and kidneys. It causes segmental necrotizing glomerulonephritis in the kidneys. In rare cases, a renal pseudotumor may be seen because of the granulomatous process. Association of WG with renal malignancy, however, is very uncommon. We report a case of a patient who presented several years after being treated for WG with malignant hypertension and an infiltrating mass in the right kidney. The histopathology of radical nephrectomy specimen showed presence of primitive neuroectodermal tumor (PNET)...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28827458/penfield-s-ceiling-seeing-brain-injury-through-galen-s-eyes
#18
Zoe M Adams, Joseph J Fins
The cathedral ceiling located in the entrance hall of the Montreal Neurological Institute, planned by its founder Wilder Penfield, has intrigued visitors since it was erected in 1934. Central to its charm is a cryptic comment by the ancient physician Galen of Pergamum, which refutes a dire Hippocratic aphorism about prognosis in brain injury. Galen's optimism, shared by Penfield, is curious from a fellow ancient. In this article, we use primary sources in Ancient Greek as well as secondary sources to not only examine the origins of Galen's epistemology but also, using a methodology in classics scholarship known as reception studies, illustrate how an awareness of this ancient debate can illuminate contemporary clinical contexts...
August 22, 2017: Neurology
https://www.readbyqxmd.com/read/28822909/variation-in-basal-body-localisation-and-targeting-of-trypanosome-rp2-and-for20-proteins
#19
Jane Harmer, Xin Qi, Gabriella Toniolo, Aysha Patel, Hannah Shaw, Fiona E Benson, Michael L Ginger, Paul G McKean
TOF-LisH-PLL motifs define FOP family proteins; some members are involved in flagellum assembly. The critical role of FOP family protein FOR20 is poorly understood. Here, we report relative localisations of the four FOP family proteins in parasitic Trypanosoma brucei: TbRP2, TbOFD1 and TbFOP/FOP1-like are mature basal body proteins whereas TbFOR20 is present on pro- and mature basal bodies - on the latter it localises distal to TbRP2. We discuss how the data, together with published work for another protist Giardia intestinalis, informs on likely FOR20 function...
July 13, 2017: Protist
https://www.readbyqxmd.com/read/28819532/a-case-of-enterobiasis-presenting-as-post-traumatic-stress-disorder-ptsd-a-curious-case-of-the-infection-with-predominant-mental-health-symptoms-presenting-for-the-first-time-in-the-settings-of-a-refugee-camp
#20
Georgios Karamitros, Nikolaos Kitsos, Fotios Athanasopoulos
Enterobiasis (oxyuriasis) is a common infection in human caused by Enterobius vermicularis (E. vermicularis), a human intestinal helminth. Because of the easy way of its transmission among people, it has an extremely high prevalence in overcrowded conditions, such as nurseries and primary schools. Oxyuriasis's symptoms are extremely diverse in children, ranging from nausea, diarrhea, insomnia, irritability, recurrent cellulitis, loss of appetite, nightmares and endometritis. Here we report a curious case of oxyuriasis in the settings of a refugee camp in Greece...
2017: Pan African Medical Journal
keyword
keyword
6980
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"