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https://www.readbyqxmd.com/read/28090730/opinions-and-potential-solutions-regarding-dissemination-bias-from-funding-agencies-of-biomedical-research-in-europe
#1
Hector Pardo-Hernandez, Gerard Urrútia, Joerg J Meerpohl, Ana Marušić, Elizabeth Wager, Xavier Bonfill
RATIONALE, AIMS, AND OBJECTIVES: Several studies have found that about half of research results from clinical trials are never published. Until now, there has been little information on the views that funding agencies of biomedical research in Europe have regarding this issue and its possible solutions. METHODS: An electronic survey was conducted among funding agencies from 34 European countries. Participants were asked about their opinions, policies, and potential solutions regarding dissemination bias...
January 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28086956/differential-expression-of-e-type-prostanoid-receptors-2-and-4-in-microglia-stimulated-with-lipopolysaccharide
#2
Ester Bonfill-Teixidor, Amaia Otxoa-de-Amezaga, Miriam Font-Nieves, M Glòria Sans-Fons, Anna M Planas
BACKGROUND: Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic actions depending on the activation of specific E-type prostanoid EP1-4 receptors. We investigated the involvement of PGE2 and EP receptors in glial activation in response to an inflammatory challenge induced by LPS. METHODS: Cultures of mouse microglia or astroglia cells were treated with LPS in the presence or absence of COX-2 inhibitors, and the production of PGE2 was measured by ELISA...
January 5, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27923833/an-essential-role-of-maspin-in-embryogenesis-and-tumor-suppression
#3
Sijana H Dzinic, M Margarida Bernardo, Xiaohua Li, Rodrigo Fernandez-Valdivia, Ye-Shih Ho, Qing-Sheng Mi, Sudeshna Bandyopadhyay, Fulvio Lonardo, Semir Vranic, Daniel Oliveira, R Daniel Bonfil, Gregory Dyson, Kang Chen, Almasa Omerovic, Xiujie Sheng, Xiang Han, Dinghong Wu, Xinling Bi, Dzenana Cabaravdic, Una Jakupovic, Marian Wahba, Aaron Pang, Deanna Harajli, Wael Sakr, Shijie Sheng
Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. In this study, we generated a mouse strain in which exon 4 of the Maspin gene was deleted, confirming its essential role in development but also enabling a breeding scheme to bypass embryonic lethality. Phenotypic characterization of this viable strain established that maspin deficiency was associated with a reduction in maximum body weight and a variety of context-dependent epithelial abnormalities...
December 6, 2016: Cancer Research
https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#4
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27905219/early-24-hour-blood-pressure-response-to-roux-en-y-gastric-bypass-in-obese-patients
#5
Julie S Pedersen, Christian Borup, Morten Damgaard, Vindhya D Yatawara, Andrea K Floyd, Niels Gadsbøll, Peter K Bonfils
Recently, it has been proposed, that the blood pressure (BP) lowering effect of gastric bypass surgery not only is explained by the obtained weight loss, but that the anatomical rearrangement of the gut after 'malabsorptive' surgical techniques, such as the laparoscopic Roux-en-Y gastric bypass (LRYGB), may affect BP through a change in a putative 'entero-renal' axis. If so one could anticipate a reduction in BP even before a noticeable weight loss was obtained. The purpose of the present study was to investigate the very early BP response to LRYGB surgery...
February 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27903137/consumer-outcomes-after-implementing-commonground-as-an-approach-to-shared-decision-making
#6
Michelle P Salyers, Sadaaki Fukui, Kelsey A Bonfils, Ruth L Firmin, Lauren Luther, Rick Goscha, Charles A Rapp, Mark C Holter
OBJECTIVE: The authors examined consumer outcomes before and after implementing CommonGround, a computer-based shared decision-making program. METHODS: Consumers with severe mental illness (N=167) were interviewed prior to implementation and 12 and 18 months later to assess changes in active treatment involvement, symptoms, and recovery-related attitudes. Providers also rated consumers on level of treatment involvement. RESULTS: Most consumers used CommonGround at least once (67%), but few used the program regularly...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27871841/rubber-particle-proteins-ref1-and-srpp1-interact-differently-with-native-lipids-extracted-from-hevea-brasiliensis-latex
#7
Kanthida Wadeesirisak, Sabine Castano, Karine Berthelot, Laurent Vaysse, Frédéric Bonfils, Frédéric Peruch, Kittipong Rattanaporn, Siriluck Liengprayoon, Sophie Lecomte, Céline Bottier
Rubber particle membranes from the Hevea latex contain predominantly two proteins, REF1 and SRPP1 involved in poly(cis-1,4-isoprene) synthesis or rubber quality. The repartition of both proteins on the small or large rubber particles seems to differ, but their role in the irreversible coagulation of the rubber particle is still unknown. In this study we highlighted the different modes of interactions of both recombinant proteins with different classes of lipids extracted from Hevea brasiliensis latex, and defined as phospholipids (PL), glycolipids (GL) and neutral lipids (NL)...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27865192/effect-of-targeted-therapy-on-circulating-progenitor-cells-in-precapillary-pulmonary-hypertension
#8
Jéssica García-Lucio, Olga Tura-Ceide, Roberto Del Pozo, Isabel Blanco, Sandra Pizarro, Elisabet Ferrer, Marta Díez, Núria Coll-Bonfill, Lucilla Piccari, Víctor I Peinado, Joan Albert Barberà
BACKGROUND: Endothelial dysfunction is key in the development of pulmonary hypertension (PH) and is associated with reduced number of circulating progenitor cells. Studies to date evaluating levels of circulating progenitor cells in PH have provided conflicting results. Current treatment of pulmonary arterial hypertension (PAH) and medical treatment of chronic thromboembolic pulmonary hypertension (CTEPH) targets endothelium dependent signalling pathways. The effect of PAH-targeted therapy on circulating progenitor cells has not been clearly established...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27785668/the-relationship-between-professional-burnout-and-quality-and-safety-in-healthcare-a-meta-analysis
#9
Michelle P Salyers, Kelsey A Bonfils, Lauren Luther, Ruth L Firmin, Dominique A White, Erin L Adams, Angela L Rollins
BACKGROUND: Healthcare provider burnout is considered a factor in quality of care, yet little is known about the consistency and magnitude of this relationship. This meta-analysis examined relationships between provider burnout (emotional exhaustion, depersonalization, and reduced personal accomplishment) and the quality (perceived quality, patient satisfaction) and safety of healthcare. METHODS: Publications were identified through targeted literature searches in Ovid MEDLINE, PsycINFO, Web of Science, CINAHL, and ProQuest Dissertations & Theses through March of 2015...
October 26, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27781948/plant-anti-cancer-agents-and-their-biotechnological-production-in-plant-cell-biofactories
#10
Liliana Lalaleo, Abbas Khojasteh, Mohammad Fattahi, Mercedes Bonfill, Rosa M Cusido, Javier Palazon
BACKGROUND: Bioactive plant secondary metabolites have complex chemical structures, which are specific to each plant species/family, and accumulate in tiny amounts. The growing market demand for many phytochemicals can lead to the over-harvesting of medicinal plants in their natural habitat, endangering species in the process. OBJECTIVE: An ongoing challenge for our society is therefore to develop a bio-sustainable production of phytochemicals, among other natural resources...
October 24, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27756576/cochrane-develops-widely-in-latin-america-and-strengthens-ties-with-latinclen
#11
Xavier Bonfill, Gerard Urrútia, Marta Roqué, María José Martínez, Hector Pardo-Hernández, Dimelza Osorio, Jordi Pardo, Pamela Seron, Maroussia Tzanova, Ivan Solà
No abstract text is available yet for this article.
October 15, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27732033/implementing-commonground-in-a-community-mental-health-center-lessons-in-a-computerized-decision-support-system
#12
Kelsey A Bonfils, Kimberly C Dreison, Lauren Luther, Sadaaki Fukui, Abigail E Dempsey, Charles A Rapp, Michelle P Salyers
Objective: Although shared decision making (SDM) is a key element of client-centered care, it has not been widely adopted. Accordingly, interventions have been developed to promote SDM. The aim of this study was to explore the implementation process of one SDM intervention, CommonGround, which utilizes peer specialists and a computerized decision support center to promote SDM. Method: As part of a larger study, CommonGround was implemented in 4 treatment teams in a community mental health center. The implementation process was examined by conducting semistructured interviews with 12 staff members that were integral to the CommonGround implementation...
October 10, 2016: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/27670928/the-performance-of-rigid-scopes-for-tracheal-intubation-a-randomised-controlled-trial-in-patients-with-a-simulated-difficult-airway
#13
M Kleine-Brueggeney, R Greif, N Urwyler, B Wirthmüller, L Theiler
We compared the Bonfils(™) and SensaScope(™) rigid fibreoptic scopes in 200 patients with a simulated difficult airway randomised to one of the two devices. A cervical collar inhibited neck movement and reduced mouth opening to a mean (SD) of 23 (3) mm. The primary outcome parameter was overall success of tracheal intubation; secondary outcomes included first-attempt success, intubation times, difficulty of intubation, fibreoptic view and side-effects. The mean (95% CI) overall success rate was 88 (80-94)% for the Bonfils and 89 (81-94)% for the SensaScope (p = 0...
December 2016: Anaesthesia
https://www.readbyqxmd.com/read/27668353/the-role-of-metacognitive-self-reflectivity-in-emotional-awareness-and-subjective-indices-of-recovery-in-schizophrenia
#14
Kelsey A Bonfils, Lauren Luther, Sunita George, Kelly D Buck, Paul H Lysaker
Emotional awareness deficits in people with schizophrenia have been linked to poorer objective outcomes, but no work has investigated the relationship between emotional awareness and subjective recovery indices or metacognitive self-reflectivity. The authors hypothesized that increased emotional awareness would be associated with greater self-esteem, hope, and self-reflectivity and that self-reflectivity would moderate links between emotional awareness and self-esteem and hope-such that significant relationships would only be observed at lower levels of self-reflectivity...
December 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27663147/sweet-syndrome-long-term-follow-up-of-138-patients
#15
J Marcoval, C Martín-Callizo, F Valentí-Medina, M Bonfill-Ortí, L Martínez-Molina
BACKGROUND: Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy-associated SS have been published in recent years. AIM: To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long-term follow-up of patients with SS. METHODS: Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27643608/job-burnout-in-mental-health-providers-a-meta-analysis-of-35-years-of-intervention-research
#16
Kimberly C Dreison, Lauren Luther, Kelsey A Bonfils, Michael T Sliter, John H McGrew, Michelle P Salyers
Burnout is prevalent among mental health providers and is associated with significant employee, consumer, and organizational costs. Over the past 35 years, numerous intervention studies have been conducted but have yet to be reviewed and synthesized using a quantitative approach. To fill this gap, we performed a meta-analysis on the effectiveness of burnout interventions for mental health workers. We completed a systematic literature search of burnout intervention studies that spanned more than 3 decades (1980 to 2015)...
September 19, 2016: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/27615385/short-term-benefits-of-an-unrestricted-calorie-traditional-mediterranean-diet-modified-with-a-reduced-consumption-of-carbohydrates-at-evening-in-overweight-obese-patients
#17
Roberto Salvia, Simona D'Amore, Giusi Graziano, Caterina Capobianco, Moris Sangineto, Domenico Paparella, Paola de Bonfils, Giuseppe Palasciano, Michele Vacca
The Mediterranean diet (MeD) is believed to promote health; nevertheless, changes in the nutritional patterns in the Mediterranean area (increased intake of refined carbohydrates/saturated fats; reduced fibers intake; main calorie load shifted to dinner) led to reduced MeD benefits in recent decades. We retrospectively investigated the effects of a MeD with a low intake of refined carbohydrates in the evening ("MeDLowC") on body weight (BW) and metabolic profile of overweight/obese subjects. According to their adherence to MeDLowC, subjects were classified into 44 (41%) individuals with "excellent" adherence and 63 (59%) with "poor" adherence...
September 12, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27560941/correction-slug-is-increased-in-vascular-remodeling-and-induces-a-smooth-muscle-cell-proliferative-phenotype
#18
Núria Coll-Bonfill, Victor I Peinado, María V Pisano, Marcelina Párrizas, Isabel Blanco, Maurits Evers, Julia C Engelmann, Jessica García-Lucio, Olga Tura-Ceide, Gunter Meister, Joan Albert Barberà, Melina M Musri
[This corrects the article DOI: 10.1371/journal.pone.0159460.].
2016: PloS One
https://www.readbyqxmd.com/read/27526311/language-and-hope-in-schizophrenia-spectrum-disorders
#19
Kelsey A Bonfils, Lauren Luther, Ruth L Firmin, Paul H Lysaker, Kyle S Minor, Michelle P Salyers
Hope is integral to recovery for those with schizophrenia. Considering recent advancements in the examination of clients' lexical qualities, we were interested in how clients' words reflect hope. Using computerized lexical analysis, we examined social, emotion, and future words' relations to hope and its pathways and agency components. Forty-five clients provided detailed narratives about their life and mental illness. Transcripts were analyzed using the Linguistic Inquiry and Word Count program (LIWC), which assigns words to categories (e...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27487637/comparison-of-the-bonfils-intubation-fibrescope-versus-c-mac-videolaryngoscope
#20
RANDOMIZED CONTROLLED TRIAL
Ai H Lee, Nadia M Nor, Azarinah Izaham, Nurlia Yahya, Shereen S P Tang, Norsidah A Manap
BACKGROUND: This prospective, randomized, single blind, single operator study was conducted to compare hemodynamic responses when endotracheal intubation was performed using the Bonfils intubation fibrescope versus the C-MAC videolaryngoscope. METHOD: Forty-four ASA I patients aged between 18 and 60 years, scheduled for elective surgery requiring endotracheal intubation were recruited. They were randomized into the Bonfils group or C-MAC group. Hemodynamic changes, laryngeal view, duration of intubation and post intubation complications were evaluated...
June 2016: Middle East Journal of Anesthesiology
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