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https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#1
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29684499/evaluation-of-the-efficacy-of-the-four-tests-p16-immunochemistry-pcr-dna-and-rna-in-situ-hybridization-to-evaluate-a-human-papillomavirus-infection-in-head-and-neck-cancers-a-cohort-of-348-french-squamous-cell-carcinomas
#2
Jérémy Augustin, Sophie Outh-Gauer, Marion Mandavit, Cassandre Gasne, Ophélie Grard, Thomas Denize, Marine Nervo, Haïtham Mirghani, Ollivier Laccourreye, Pierre Bonfils, Patrick Bruneval, David Veyer, Hélène Péré, Eric Tartour, Cécile Badoual
It is now established that HPV plays a role in the development of a subset of head and neck squamous cell carcinomas (HNSCCs), notably oropharyngeal squamous cell carcinomas (SCCs). However, it is not clear which test one should use to detect HPV in oropharyngeal (OP) and non-OP SCCs. In this study, using 348 HNSCCs (126 OP SCCs and 222 non-OP SCCs), we evaluated diagnostic performances of different HPV tests in OP and non-OP SCCs: PCR, p16 immunostaining, in situ hybridization targeting DNA (DNA-CISH) and RNA (RNA-CISH), combined p16 + DNA-CISH, and combined p16 + RNA-CISH...
April 20, 2018: Human Pathology
https://www.readbyqxmd.com/read/29679793/self-stigma-in-ptsd-prevalence-and-correlates
#3
Kelsey A Bonfils, Paul H Lysaker, Philip T Yanos, Alysia Siegel, Bethany L Leonhardt, Alison V James, Beth Brustuen, Brandi Luedtke, Louanne W Davis
Self-stigma is the internalization of negative societal stereotypes about those with mental illnesses. While self-stigma has been carefully characterized in severe mental disorders, like schizophrenia, the field has yet to examine the prevalence and correlates of self-stigma in post-traumatic stress disorder (PTSD). Thus, we assessed self-stigma in veterans diagnosed with PTSD and compared with veterans with schizophrenia. We further examined associations between PTSD, depressive symptoms and self-stigma in the PTSD sample...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679792/metacognitive-self-reflectivity-moderates-the-relationship-between-distress-tolerance-and-empathy-in-schizophrenia
#4
Kelsey A Bonfils, Kyle S Minor, Bethany L Leonhardt, Paul H Lysaker
Deficits in empathy seen in schizophrenia are thought to play a major role in the social dysfunction seen in the disorder. However, little work has investigated potential determinants of empathic deficits. This study aimed to fill that gap by examining the effects of two variables on empathy - distress tolerance and metacognitive self-reflectivity. Fifty-four people with schizophrenia-spectrum disorders receiving services at an urban VA or community mental health center were assessed for empathy, metacognition, and distress tolerance...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677067/reflections-on-combining-the-bonfils-intubation-endoscope-the-macintosh-videolaryngocope-and-the-difficult-airway
#5
Sinead E McCarthy, Richard M Cooper
No abstract text is available yet for this article.
April 19, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29672621/imbalance-between-endothelial-damage-and-repair-capacity-in-chronic-obstructive-pulmonary-disease
#6
Jéssica García-Lucio, Victor I Peinado, Lluís de Jover, Roberto Del Pozo, Isabel Blanco, Cristina Bonjoch, Núria Coll-Bonfill, Tanja Paul, Olga Tura-Ceide, Joan Albert Barberà
BACKGROUND: Circulating endothelial microparticles (EMPs) and progenitor cells (PCs) are biological markers of endothelial function and endogenous repair capacity. The study was aimed to investigate whether COPD patients have an imbalance between EMPs to PCs compared to controls and to evaluate the effect of cigarette smoke on these circulating markers. METHODS: Circulating EMPs and PCs were determined by flow cytometry in 27 nonsmokers, 20 smokers and 61 COPD patients with moderate to severe airflow obstruction...
2018: PloS One
https://www.readbyqxmd.com/read/29664911/hpv-relatedness-definitions-for-classifying-hpv-related-oropharyngeal-cancer-patient-do-impact-on-tnm-classification-and-patients-survival
#7
Miren Taberna, Marisa Mena, Sara Tous, Miquel Angel Pavón, Marc Oliva, Xavier León, Jacinto Garcia, Marta Guix, Rafael Hijano, Teresa Bonfill, Antón Aguilà, Laia Alemany, Ricard Mesía
BACKGROUND: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. MATERIAL AND METHODS: The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests...
2018: PloS One
https://www.readbyqxmd.com/read/29566881/extragenital-lichen-sclerosus-induced-by-radiotherapy
#8
M Bonfill-Ortí, L Martínez-Molina, R M Penín, J Marcoval
No abstract text is available yet for this article.
March 19, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29557590/what-are-the-remaining-limitations-of-tavi
#9
REVIEW
Chiara De Biase, Antonios Mastrokostopoulos, Raphael Philippart, Laurent Bonfils, Pierre Berthoumieu, Nicolas Dumonteil
Transcatheter aortic valve implantation (TAVI) is a recognized therapy for patients with symptomatic severe aortic stenosis (AS). TAVI is superior compared to medical therapy as for mortality in extreme-risk patients, is non-inferior or superior to surgery in high-risk patients and non-inferior to surgery in intermediate-risk patients. However, several limitations affect outcomes after TAVI. Adverse events related to this procedure, like vascular complications, need for pacemaker implantation, paravalvular regurgitation, can be factors limiting TAVI treatment in younger patients at lower risk, as well as uncertainties regarding valve durability...
June 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29547765/quality-assessment-of-clinical-practice-guidelines-on-treatments-for-oral-cancer
#10
REVIEW
Meisser Vidal Madera Anaya, Juan Victor Franco, Ángela María Merchán-Galvis, Carmen R Gallardo, Xavier Bonfill Cosp
BACKGROUND: The applicability of clinical practice guidelines (CPGs) on treatments for oral cancer remains unknown since there are no systematic assessments of their quality. Thus, the objective of this study is to identify and assess the quality of them. METHODS: We conducted a systematic search to identify CPGs that provided recommendations on treatments for oral cancer. The quality of each included CPG was determined using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument, by four appraisers independently...
April 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29546594/correction-to-curative-radiation-therapy-for-very-elderly-bladder-cancer-patients-with-localized-disease
#11
M Bonet, T Bonfill, M Nuñez, L De Verdonces, E Mur, E Gallardo, L Fernandez-Morales, A Aguilar, J Prats, M Arenas
In the original version of this article the figure captions of Figs. 1 and 2 were interchanged.
March 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29546560/study-protocol-for-a-multicenter-prospective-controlled-and-randomized-trial-of-transanal-total-mesorectal-excision-versus-laparoscopic-low-anterior-resection-in-rectal-cancer
#12
X Serra-Aracil, A Zárate, L Mora, S Serra-Pla, A Pallisera, J Bonfill, J Bargalló, A Pando, S Delgado, E Balleteros, C Pericay
PURPOSE: Compared with the open approach, laparoscopic total mesorectal excision (TME) achieves faster patient recovery, reduces morbidity rates, and shortens hospital stay. However, in laparoscopic low anterior resection (L-LAR), conversion to open surgery is required in almost 20% of cases. Transanal TME (Ta-TME) combined with laparoscopy, also called hybrid natural orifice transluminal endoscopic surgery (NOTES), is a less invasive procedure that can overcome some of the limitations of laparoscopic rectal surgery...
May 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29521202/biotechnological-production-of-pharmaceuticals-and-biopharmaceuticals-in-plant-cell-and-organ-cultures
#13
Diego Hidalgo, Raul Sanchez, Liliana Lalaleo, Mercedes Bonfill, Purificacion Corchete, Javier Palazon
BACKGROUND: Plant biofactories are biotechnological platforms based on plant cell and organ cultures used for the production of pharmaceuticals and biopharmaceuticals, although to date only a few of these systems have successfully been implemented at an industrial level. Metabolic engineering is possibly the most straightforward strategy to boost pharmaceutical production in plant biofactories, but social opposition to the use of GMOs means empirical approaches are still being used. Plant secondary metabolism involves thousands of different enzymes, some of which catalyze specific reactions, giving one product from a particular substrate, whereas others can yield multiple products from the same substrate...
March 9, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29496272/-management-of-vertigo-and-dizziness
#14
D Bouccara, F Rubin, P Bonfils, Q Lisan
Balance disorders presenting with symptoms of dizziness and vertigo are due to various diseases. Clinical approach gives the opportunity to identify emergency situations and most common causes, among them the first one being the benign paroxysmal positional vertigo. Oculomotor assessment is pertinent as major clinical orientation, particularly between peripheral and central diseases. These clinical findings support the respective indication of modern imaging and/or vestibular tests, focused on the direction of presupposed diagnosis...
February 26, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29496041/double-positivity-for-hpv-dna-p16-ink4a-is-the-biomarker-with-strongest-diagnostic-accuracy-and-prognostic-value-for-human-papillomavirus-related-oropharyngeal-cancer-patients
#15
Marisa Mena, Miren Taberna, Sara Tous, Sandra Marquez, Omar Clavero, Beatriz Quiros, Belen Lloveras, Maria Alejo, Xavier Leon, Miquel Quer, Silvia Bagué, Ricard Mesia, Julio Nogués, Montserrat Gomà, Anton Aguila, Teresa Bonfill, Carmen Blazquez, Marta Guix, Rafael Hijano, Montserrat Torres, Dana Holzinger, Michael Pawlita, Miguel Angel Pavon, Ignacio G Bravo, Silvia de Sanjosé, Francesc Xavier Bosch, Laia Alemany
BACKGROUND: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. METHODS: We conducted a retrospective cohort study of all patients diagnosed with a primary OPC in four Catalonian hospitals from 1990 to 2013. Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a /pRb/p53/Cyclin-D1 immunohistochemistry...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29466729/a-cell-intrinsic-interferon-like-response-links-replication-stress-to-cellular-aging-caused-by-progerin
#16
Ray Kreienkamp, Simona Graziano, Nuria Coll-Bonfill, Gonzalo Bedia-Diaz, Emily Cybulla, Alessandro Vindigni, Dale Dorsett, Nard Kubben, Luis Francisco Zirnberger Batista, Susana Gonzalo
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts accumulate genomic instability, but its underlying mechanisms and contribution to disease remain poorly understood. Here, we show that progerin-induced replication stress (RS) drives genomic instability by eliciting replication fork (RF) stalling and nuclease-mediated degradation. Rampant RS is accompanied by upregulation of the cGAS/STING cytosolic DNA sensing pathway and activation of a robust STAT1-regulated interferon (IFN)-like response...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29465200/-the-choice-of-tracheal-intubation-method-in-reconstructive-maxillo-facial-surgery-with-difficult-airways
#17
A Yu Zaytcev, K V Dubrovin, V A Svetlov
BACKGROUND: The development of modern video - and endoscopic equipment allows for revision and adjust to modern protocols for maintaining patency of the difficult airway, especially in maxillofacial or ENT -surgery. THE PURPOSE OF THE STUDY: Comparison the efficacy ofvarious methods of maintaining the airway patency in the practice of reconstructive maxillofacial surgery. MATERIALS AND METHODS: 89 patients, who were divided into 4 groups, were examined...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29447809/difficult-airway-intubation-simulation-using-bonfils-fiberscope-and-rigid-fiberscope-for-surgical-training
#18
Harish Dharmarajan, Yi-Chun Carol Liu, Helena Karlberg Hippard, Binoy Chandy
INTRODUCTION: Pediatric otolaryngologists are frequently called to assist in difficult airway management in newborns with Pierre Robin Sequence (PRS) who have microretrognathia, glossoptosis, and an anterior larynx. The Bonfils fiberscope (BF) is a curved rigid scope designed to provide superior visualization in the anterior larynx. OBJECTIVE: (1) to assess whether BF provides an improvement in intubation success rate, time to intubation, or airway visualization as compared to rigid fiberscope (RF) in a difficult airway simulation setting and (2) to determine whether a training program for BF can improve time to intubation through practice trials...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29402673/idiopathic-unilateral-vocal-fold-paralysis-in-the-adult
#19
F Rubin, A Villeneuve, L Alciato, L Slaïm, P Bonfils, O Laccourreye
GOAL: To analyze the characteristics of adult idiopathic unilateral vocal-fold paralysis. MATERIAL AND METHODS: Retrospective study of diagnostic problems, clinical data and recovery in an inception cohort of 100 adult patients with idiopathic unilateral vocal-fold paralysis (Group A) and comparison with a cohort of 211 patients with isolated non-idiopathic non-traumatic unilateral vocal-fold paralysis (Group B). RESULTS: Diagnostic problems were noted in 24% of cases in Group A: eight patients with concomitant common upper aerodigestive tract infection, five patients with a concomitant condition liable to induce immunodepression and 11 patients in whom a malignant tumor occurred along the path of the ipsilateral vagus and inferior laryngeal nerves or in the ipsilateral paralyzed larynx...
February 2, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29373991/ethnomycological-knowledge-in-three-communities-in-amealco-qu%C3%A3-retaro-m%C3%A3-xico
#20
Daniel Robles-García, Humberto Suzán-Azpiri, Adriana Montoya-Esquivel, Jesús García-Jiménez, Edgardo Ulises Esquivel-Naranjo, Elhadi Yahia, Fidel Landeros-Jaime
BACKGROUND: Fungi have multiple uses in temperate areas of México, but an important decrease in the traditional knowledge of uses and customs of mushrooms becomes a fundamental issue for fungi conservation. However, only few studies quantify the traditional ethnomycological knowledge in México, and this study is the first quantitative report for Querétaro, a central state with both Otomí and Mestizo communities and a high fungi diversity. METHODS: The present study was conducted registering traditional knowledge on the use and consumption of mushrooms in three Hñähñu (Otomí) communities (Tesquedó, Xajay, and Tenasdá) in Amealco de Bonfil, Querétaro, México, between August 2013 and November 2014...
January 26, 2018: Journal of Ethnobiology and Ethnomedicine
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