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https://www.readbyqxmd.com/read/27906081/vacht-overexpression-increases-acetylcholine-at-the-synaptic-cleft-and-accelerates-aging-of-neuromuscular-junctions
#1
Satoshi Sugita, Leland L Fleming, Caleb Wood, Sydney K Vaughan, Matheus P S M Gomes, Wallace Camargo, Ligia A Naves, Vania F Prado, Marco A M Prado, Cristina Guatimosim, Gregorio Valdez
BACKGROUND: Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to age- and disease-related degeneration of the motor system. Here we investigated the effect of moderately increasing levels of synaptic acetylcholine (ACh) on the neuromuscular junction (NMJ), muscle fibers, and motor neurons during development and aging and in a mouse model for amyotrophic lateral sclerosis (ALS)...
October 5, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905185/how-to-write-a-paper-revising-your-manuscript
#2
Bruce Su'a, Wiremu S MacFater, Andrew G Hill
No abstract text is available yet for this article.
November 30, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27904898/a-dual-photoluminescence-enhancement-system-stabilization-of-a-water-soluble-aiee-fluorogen-using-silver-nanowire
#3
Ying-Chen Chiang, Chun-Ta Huang, Wei Hsin Wang, Cheng-Chung Chang
This manuscript describes the preparation of water soluble aggregation-induced emission enhancement (AIEE)-based fluorescent organic nanoparticles (FONs). The fluorescence diversity of the FONs was investigated in the presence of silver nanowires. We observed that the emission of the FONs can be enhanced by mixing with the nanowires, which is believed to originate from resonance between the emission of the FONs and the surface plasmon resonances of the metal surface. That is, the AIEE phenomenon was promoted according to the metal-enhanced fluorescence (MEF) mechanism that can be used to build up a novel double emission enhancement (DEE) platform and to extend the range of AIEE applications...
December 1, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27904419/reporting-statistical-results-in-medical-journals
#4
EDITORIAL
Wan Nor Arifin, Abdullah Sarimah, Bachok Norsa'adah, Yaacob Najib Majdi, Ab Hamid Siti-Azrin, Musa Kamarul Imran, Abd Aziz Aniza, Lin Naing
Statistical editors of the Malaysian Journal of Medical Sciences (MJMS) must go through many submitted manuscripts, focusing on the statistical aspect of the manuscripts. However, the editors notice myriad styles of reporting the statistical results, which are not standardised among the authors. This could be due to the lack of clear written instructions on reporting statistics in the guidelines for authors. The aim of this editorial is to briefly outline reporting methods for several important and common statistical results...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27904060/causative-agents-of-aspergillosis-including-cryptic-aspergillus-species-and-a-fumigatus
#5
Takahito Toyotome
Aspergillosis is an important deep mycosis. The causative agents are Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, and Aspergillus terreus, of which A. fumigatus is the most prevalent. Cryptic Aspergillus spp., which morphologically resemble representative species of each Aspergillus section, also cause aspergillosis. Most of the cryptic species reveal different susceptibility patterns and/or different secondary metabolite profiles, also called exometabolome in this manuscript, from those representative species...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27903921/a-two-pool-model-to-describe-the-ivim-cerebral-perfusion
#6
Gabrielle Fournet, Jing-Rebecca Li, Alex M Cerjanic, Bradley P Sutton, Luisa Ciobanu, Denis Le Bihan
IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm(2) at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model...
November 30, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27903303/associated-factors-of-self-reported-psychopathology-and-health-related-quality-of-life-among-men-who-have-sex-with-men-msm-with-hiv-aids-in-dalian-china-a-pilot-study
#7
Tesfaldet Habtemariam Hidru, Feng Wang, Sainyugu Lolokote, Yong Jia, Min Chen, Wei Tong, Xiao-Feng Li
BACKGROUND: Despite the availability of Anti-Retroviral Therapy (ART), the health-related quality of life (HRQoL) among HIV-positive men who have sex with men (HIVMSM) in China remains poor. This study aimed to explore the relationship between self-reported psychopathology and HRQoL among HIVMSM in Dalian, China. METHODS: A cross-sectional study was conducted in 112 HIVMSM. Symptom check list 90 (SCL 90): a measure of psychopathology and World Health Organization quality of life in HIV infection (WHOQOL-HIV-Bref): a measure of HRQoL were used...
December 1, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27903302/preventing-the-ends-from-justifying-the-means-withholding-results-to-address-publication-bias-in-peer-review
#8
EDITORIAL
Katherine S Button, Liz Bal, Anna Clark, Tim Shipley
The evidence that many of the findings in the published literature may be unreliable is compelling. There is an excess of positive results, often from studies with small sample sizes, or other methodological limitations, and the conspicuous absence of null findings from studies of a similar quality. This distorts the evidence base, leading to false conclusions and undermining scientific progress. Central to this problem is a peer-review system where the decisions of authors, reviewers, and editors are more influenced by impressive results than they are by the validity of the study design...
December 1, 2016: BMC Psychology
https://www.readbyqxmd.com/read/27903082/itraconazole-induced-thrombocytopenia
#9
Berna Aksoy
Itraconazole is one of the systemic treatment options for extensive tinea versicolor. A male patient who developed thrombocytopenia during the treatment of tinea versicolor by itraconazole is reported in this manuscript. He was diagnosed to develop thrombocytopenia on the third day of treatment. In the literature, there are two reports of itraconazole induced thrombocytopenia both in malignancy patients. One report contained three patients who developed thrombocytopenia as a result of a drug interaction between bortezomib and itraconazole...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27902885/recent-advances-and-applications-of-gas-chromatography-vacuum-ultraviolet-spectroscopy
#10
REVIEW
Inês C Santos, Kevin A Schug
The vacuum ultraviolet spectrophotometer was developed recently as an alternative to existing gas chromatography detectors. This detector measures the absorption of gas-phase chemical species in the range of 120-240 nm, where all chemical compounds present unique absorption spectra. Therefore, qualitative analysis can be performed and quantification follows standard Beer-Lambert law principles. Different fields of application, such as petrochemical, food, and environmental analysis have been explored. Commonly demonstrated is the capability for facile deconvolution of co-eluting analytes...
November 7, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27902659/call-for-manuscripts
#11
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/27900309/from-loose-body-to-osteochondritis-dissecans-a-historical-account-of-disease-definition
#12
Vittorio Tarabella, Giuseppe Filardo, Berardo DI Matteo, Luca Andriolo, Patrizia Tomba, Anna Viganò, Maurilio Marcacci
Osteochondritis dissecans (OCD) is a rare yet fascinating disease affecting young, active patients. It remains a 'mysterious disease' whose etiopathology, still unclear, is the subject of ongoing studies aiming improving the knowledge of this condition and, therefore, treatment options, too. Even though the first descriptions of intra-articular loose bodies date back to very ancient times, it is only relatively recently that, thanks to the contribution of some very eminent physicians, it became recognized as a specific orthopaedic condition...
July 2016: Joints
https://www.readbyqxmd.com/read/27899907/context-specific-proportion-congruency-effects-an-episodic-learning-account-and-computational-model
#13
James R Schmidt
In the Stroop task, participants identify the print color of color words. The congruency effect is the observation that response times and errors are increased when the word and color are incongruent (e.g., the word "red" in green ink) relative to when they are congruent (e.g., "red" in red). The proportion congruent (PC) effect is the finding that congruency effects are reduced when trials are mostly incongruent rather than mostly congruent. This PC effect can be context-specific. For instance, if trials are mostly incongruent when presented in one location and mostly congruent when presented in another location, the congruency effect is smaller for the former location...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27899721/lisfranc-injuries-in-the-athlete
#14
REVIEW
John S Lewis, Robert B Anderson
: Lisfranc injuries to the tarsometatarsal complex of the midfoot have become increasingly recognized in the athletic population. Regardless of mechanism, any injury that results in instability in the midfoot requires operative stabilization to preserve function and enable return to sport. In this manuscript, the anatomy, etiology, prevalence, current treatment modalities, and clinical outcomes of patients who suffer Lisfranc injuries are reviewed, with a special focus on the unique characteristics surrounding such an injury in an athlete...
December 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27899678/virus-variation-resource-improved-response-to-emergent-viral-outbreaks
#15
Eneida L Hatcher, Sergey A Zhdanov, Yiming Bao, Olga Blinkova, Eric P Nawrocki, Yuri Ostapchuck, Alejandro A Schäffer, J Rodney Brister
The Virus Variation Resource is a value-added viral sequence data resource hosted by the National Center for Biotechnology Information. The resource is located at http://www.ncbi.nlm.nih.gov/genome/viruses/variation/ and includes modules for seven viral groups: influenza virus, Dengue virus, West Nile virus, Ebolavirus, MERS coronavirus, Rotavirus A and Zika virus Each module is supported by pipelines that scan newly released GenBank records, annotate genes and proteins and parse sample descriptors and then map them to controlled vocabulary...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899676/transportdb-2-0-a-database-for-exploring-membrane-transporters-in-sequenced-genomes-from-all-domains-of-life
#16
Liam D H Elbourne, Sasha G Tetu, Karl A Hassan, Ian T Paulsen
All cellular life contains an extensive array of membrane transport proteins. The vast majority of these transporters have not been experimentally characterized. We have developed a bioinformatic pipeline to identify and annotate complete sets of transporters in any sequenced genome. This pipeline is now fully automated enabling it to better keep pace with the accelerating rate of genome sequencing. This manuscript describes TransportDB 2.0 (http://www.membranetransport.org/transportDB2/), a completely updated version of TransportDB, which provides access to the large volumes of data generated by our automated transporter annotation pipeline...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899672/the-swiss-model-repository-new-features-and-functionality
#17
Stefan Bienert, Andrew Waterhouse, Tjaart A P de Beer, Gerardo Tauriello, Gabriel Studer, Lorenza Bordoli, Torsten Schwede
SWISS-MODEL Repository (SMR) is a database of annotated 3D protein structure models generated by the automated SWISS-MODEL homology modeling pipeline. It currently holds >400 000 high quality models covering almost 20% of Swiss-Prot/UniProtKB entries. In this manuscript, we provide an update of features and functionalities which have been implemented recently. We address improvements in target coverage, model quality estimates, functional annotations and improved in-page visualization. We also introduce a new update concept which includes regular updates of an expanded set of core organism models and UniProtKB-based targets, complemented by user-driven on-demand update of individual models...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899612/ymdb-2-0-a-significantly-expanded-version-of-the-yeast-metabolome-database
#18
Miguel Ramirez-Gaona, Ana Marcu, Allison Pon, An Chi Guo, Tanvir Sajed, Noah A Wishart, Naama Karu, Yannick Djoumbou Feunang, David Arndt, David S Wishart
YMDB or the Yeast Metabolome Database (http://www.ymdb.ca/) is a comprehensive database containing extensive information on the genome and metabolome of Saccharomyces cerevisiae Initially released in 2012, the YMDB has gone through a significant expansion and a number of improvements over the past 4 years. This manuscript describes the most recent version of YMDB (YMDB 2.0). More specifically, it provides an updated description of the database that was previously described in the 2012 NAR Database Issue and it details many of the additions and improvements made to the YMDB over that time...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899261/a-prestimulation-evaluation-protocol-for-patients-with-drug-resistant-epilepsy
#19
Sofie Carrette, Paul Boon, Kristl Vonck
Neurostimulation is making its way into the therapeutic armamentarium of the epileptologists, with several invasive neurostimulation modalities available today and several less invasive modalities under investigation. Clinicians will soon face a choice that should not be made randomly. We introduce the concept of a prestimulation evaluation protocol, consisting of a series of rationally chosen investigations that evaluate the presence of biomarkers for response to various neurostimulation therapies. These biomarkers should reflect the susceptibility of the individual's epileptic network to a given neurostimulation technique...
November 19, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27897149/a-density-functional-theory-for-association-of-fluid-molecules-with-a-functionalized-surface-fluid-wall-single-and-double-bonding
#20
Amin Haghmoradi, Le Wang, Walter G Chapman
In this manuscript we extend Wertheim's two-density formalism beyond its first order to model a system of fluid molecules with a single association site close to a planar hard wall with association sites on its surface in a density functional theory framework. The association sites of the fluid molecules are small enough that they can form only one bond, while the wall association sites are large enough to bond with more than one fluid molecule. The effects of temperature and of bulk fluid and wall site densities on the fluid density profile, extent of association, and competition between single and double bonding of fluid segments at the wall sites versus distance from the wall are presented...
November 29, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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