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https://www.readbyqxmd.com/read/29457846/dispositional-malevolence-and-impression-formation-dark-tetrad-associations-with-accuracy-and-positivity-in-first-impressions
#1
Katherine H Rogers, Marina T Le, Erin E Buckels, Mikayla Kim, Jeremy C Biesanz
INTRODUCTION: The Dark Tetrad traits (subclinical psychopathy, narcissism, Machiavellianism, and everyday sadism) have interpersonal consequences. At present, however, how these traits are associated with the accuracy and positivity of first impressions is not well understood. OBJECTIVES: The present manuscript addresses three primary questions. First, to what extent are perceiver levels of Dark Tetrad traits associated with differing levels of perceptive accuracy? Second, to what extent are target levels of Dark Tetrad traits associated with differing levels of expressive accuracy? Finally, to what extent can Dark Tetrad traits be differentiated when examining perceptions of and by others? METHODS: In a round-robin design, participants (N = 412) in small groups engaged in brief, naturalistic, unstructured dyadic interactions before providing impressions of their partner...
February 19, 2018: Journal of Personality
https://www.readbyqxmd.com/read/29457240/manuscript-reviewers-2017
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29456521/mathematical-modeling-of-protein-misfolding-mechanisms-in-neurological-diseases-a-historical-overview
#3
REVIEW
Felix Carbonell, Yasser Iturria-Medina, Alan C Evans
Protein misfolding refers to a process where proteins become structurally abnormal and lose their specific 3-dimensional spatial configuration. The histopathological presence of misfolded protein (MP) aggregates has been associated as the primary evidence of multiple neurological diseases, including Prion diseases, Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jacob disease. However, the exact mechanisms of MP aggregation and propagation, as well as their impact in the long-term patient's clinical condition are still not well understood...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29456356/the-current-state-of-rural-neurosurgical-practice-an-international-perspective
#4
REVIEW
Pavan S Upadhyayula, John K Yue, Jason Yang, Harjus S Birk, Joseph D Ciacci
Introduction: Rural and low-resource areas have diminished capacity to care for neurosurgical patients due to lack of infrastructure, healthcare investment, and training programs. This review summarizes the range of rural neurosurgical procedures, novel mechanisms for delivering care, rapid training programs, and outcome differences across international rural neurosurgical practice. Methods: A comprehensive literature search was performed for English language manuscripts with keywords "rural" and "neurosurgery" using the National Library of Medicine PubMed database (01/1971-06/2017)...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456097/the-timing-of-early-therapeutic-strategies-has-a-significant-impact-on-crohn-s-disease-prognosis
#5
Cláudia Camila Dias, Francisco Portela, Samuel Fernandes, Paula Ministro, Paula Lago, Isadora Rosa, Luis Correia, Fernando Magro
BACKGROUND: Abdominal surgery and immunosuppressive pharmacological treatments are two different therapeutic options used to manage Crohn disease. This study aimed to determine whether the timing of these interventions had an impact on patients' prognosis. METHOD: This manuscript entails a retrospective analysis of a multicentric cohort involving 498 CD patients that had bowel surgery after diagnosis and prior to immunosuppression treatments. Two endpoints were considered: the occurrence of disabling disease and the need to undergo further bowel surgeries...
February 1, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29455722/computer-assisted-motivational-interviewing-intervention-to-facilitate-teen-pregnancy-prevention-and-fitness-behavior-changes-a-randomized-trial-for-young-men
#6
David L Bell, Samantha Garbers, Marina Catallozzi, R Stanley Hum, Meredith Nechitilo, Ian W McKeague, Emilia H Koumans, L Duane House, Susan L Rosenthal, Melanie A Gold
PURPOSE: Despite recent declines, teen unintended pregnancy and sexually transmitted infections in the United States remain at levels higher than comparable nations. Initiatives to prevent teen pregnancy have focused primarily on female adolescents; how to effectively engage young men to reduce their risk of fathering a teen pregnancy has not been well studied. We proposed to adapt an innovative computer-assisted motivational interviewing (CAMI) intervention, originally designed and tested with young women, for use with young men, aged 15-24 years, to reduce their risk of fathering a teen pregnancy...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29455648/mechanisms-of-receptor-tyrosine-kinase-activation-in-cancer
#7
REVIEW
Zhenfang Du, Christine M Lovly
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies have revealed the presence of various alterations in the genes encoding RTKs such as EGFR, HER2/ErbB2, and MET, amongst many others. Abnormal RTK activation in human cancers is mediated by four principal mechanisms: gain-of-function mutations, genomic amplification, chromosomal rearrangements, and / or autocrine activation...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455331/newborn-screening-guidelines-for-congenital-hypothyroidism-in-india-recommendations-of-the-indian-society-for-pediatric-and-adolescent-endocrinology-ispae-part-ii-imaging-treatment-and-follow-up
#8
REVIEW
S Sudhanshu, I Riaz, R Sharma, M P Desai, R Parikh, V Bhatia
The Indian Society for Pediatric and Adolescent Endocrinology has formulated Clinical Practice Guidelines for newborn screening, diagnosis and management of congenital hypothyroidism (CH). This manuscript, part II addresses management and follow-up. RECOMMENDATIONS: Screening should be done for every newborn using cord blood, or postnatal blood ideally at 48 to 72 h of age. Neonates with screen TSH > 20 mIU/L serum units (or >34 mIU/L for samples taken between 24 and 48 h of age) should be recalled for confirmation...
February 17, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29455273/updates-on-device-based-therapies-for-patients-with-heart-failure
#9
REVIEW
Jad Al Danaf, Javed Butler, Amin Yehya
PURPOSE OF REVIEW: Heart failure is a growing epidemic. Optimal medical therapy remains the cornerstone of heart failure management but device-based therapies have been shown to contribute to morbidity and mortality reduction. RECENT FINDINGS: Multiple investigational trials had been conducted in the past decade that helped us better understand and manage heart failure. In this manuscript, we will discuss the major device related trials of year 2017 in the fields of defibrillators, hemodynamic monitoring, remote monitoring, autonomic nervous system modulation, ventricular assist devices, and device-based valvular heart disease management...
February 17, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29455260/performance-evaluation-of-state-of-the-art-local-feature-detectors-and-descriptors-in-the-context-of-longitudinal-registration-of-retinal-images
#10
Sajib K Saha, Di Xiao, Shaun Frost, Yogesan Kanagasingam
In this paper we systematically evaluate the performance of several state-of-the-art local feature detectors and descriptors in the context of longitudinal registration of retinal images. Longitudinal (temporal) registration facilitates to track the changes in the retina that has happened over time. A wide number of local feature detectors and descriptors exist and many of them have already applied for retinal image registration, however, no comparative evaluation has been made so far to analyse their respective performance...
February 17, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29455163/theory-of-change-for-the-delivery-of-talking-therapies-by-lay-workers-to-survivors-of-humanitarian-crises-in-low-income-and-middle-income-countries-protocol-of-a-systematic-review
#11
Grace Kathryn Ryan, Andreas Bauer, Judith K Bass, Julian Eaton
INTRODUCTION: There is a severe shortage of specialist mental healthcare providers in low-income and middle-income countries (LMICs) affected by humanitarian crises. In these settings, talking therapies may be delivered by non-specialists, including lay workers with no tertiary education or formal certification in mental health. This systematic review will synthesise the literature on the implementation and effectiveness of talking therapies delivered by lay workers in LMICs affected by humanitarian crises, in order to develop a Theory of Change (ToC)...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29454483/postoperative-opioid-prescribing-getting-it-rightt
#12
REVIEW
Brian K Yorkgitis, Gabriel A Brat
BACKGROUND: Prescription opioid medications account for a large number of fatal and non-fatal overdoses. Many opioid prescription medications after surgery go unused, with the potential for diversion and misuse. As surgeons become increasingly aware of their role in opioid misuse, better tools are needed to guide behavior. DATA SOURCES: There has recently been a plethora of research into opioid prescribing after surgery. A review of this literature was performed using a search for manuscripts written in the English language...
February 6, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29454350/application-of-four-dimension-criteria-to-assess-rigour-of-qualitative-research-in-emergency-medicine
#13
Roberto Forero, Shizar Nahidi, Josephine De Costa, Mohammed Mohsin, Gerry Fitzgerald, Nick Gibson, Sally McCarthy, Patrick Aboagye-Sarfo
BACKGROUND: The main objective of this methodological manuscript was to illustrate the role of using qualitative research in emergency settings. We outline rigorous criteria applied to a qualitative study assessing perceptions and experiences of staff working in Australian emergency departments. METHODS: We used an integrated mixed-methodology framework to identify different perspectives and experiences of emergency department staff during the implementation of a time target government policy...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29453734/post-operative-imaging-assessment-of-non-functioning-pituitary-adenomas
#14
REVIEW
Kunal S Patel, Sanjay Dhawan, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen
BACKGROUND: Non-functioning pituitary adenomas (NFAs) are the most common pituitary tumors. There is significant variability in clinical practice in terms of post-operative imaging evaluation. The objective of this manuscript is to provide an exhaustive review of published articles pertaining to the post-operative imaging evaluation of NFAs. METHODS: The MEDLINE database was queried for studies investigating imaging for the post-operative evaluation of pituitary adenomas...
February 16, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29453507/interprofessional-education-opportunities-and-challenges-for-psychology
#15
Wendy Ward, Alexandra Zagoloff, Cortney Rieck, William Robiner
This manuscript is an outgrowth of an invited panel presentation at the national Association for Psychologists in Academic Health Centers Conference in 2017 on Interprofessional Education (IPE). IPE is a structured and transformative educational strategy designed to provide active learning experiences where trainees from diverse healthcare professions gain shared content knowledge plus collaboration skills as they learn about, from, and with each other. Collaboration skills include understanding professional role distinctions and overlap, effective team-based communication, shared values/ethics and respect for each other's expertise, and teamwork dynamics...
February 16, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29453190/testing-behavior-change-techniques-to-encourage-primary-care-physicians-to-access-cancer-screening-audit-and-feedback-reports-protocol-for-a-factorial-randomized-experiment-of-email-content
#16
Gratianne Vaisson, Holly O Witteman, Zachary Bouck, Caroline A Bravo, Laura Desveaux, Diego Llovet, Justin Presseau, Marianne Saragosa, Monica Taljaard, Shama Umar, Jeremy M Grimshaw, Jill Tinmouth, Noah M Ivers
BACKGROUND: Cancer Care Ontario's Screening Activity Report (SAR) is an online audit and feedback tool designed to help primary care physicians in Ontario, Canada, identify patients who are overdue for cancer screening or have abnormal results requiring follow-up. Use of the SAR is associated with increased screening rates. To encourage SAR use, Cancer Care Ontario sends monthly emails to registered primary care physicians announcing that updated data are available. However, analytics reveal that 50% of email recipients do not open the email and less than 7% click the embedded link to log in to their report...
February 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29452802/moving-to-human-trials-for-argon-neuroprotection-in-neurological-injury-a-narrative-review
#17
REVIEW
A J Gardner, D K Menon
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily modifiable variable in resuscitation; gases are relatively simple to administer. Xenon is the prototypic agent of a new generation of experimental treatments which show promise. However, use is hindered by its prohibitive cost and anaesthetic properties. Argon is an attractive option, being cheaper, easy to transport, non-sedating, and mechanistically distinct from xenon...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452276/application-of-targeted-mass-spectrometry-in-bottom-up-proteomics-for-systems-biology-research
#18
Nathan P Manes, Aleksandra Nita-Lazar
The enormous diversity of proteoforms produces tremendous complexity within cellular proteomes, facilitates intricate networks of molecular interactions, and constitutes a formidable analytical challenge for biomedical researchers. Currently, quantitative whole-proteome profiling often relies on non-targeted liquid chromatography-mass spectrometry (LC-MS), which samples proteoforms broadly, but can suffer from lower accuracy, sensitivity, and reproducibility compared with targeted LC-MS. Recent advances in bottom-up proteomics using targeted LC-MS have enabled previously unachievable identification and quantification of target proteins and posttranslational modifications within complex samples...
February 13, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29451819/protection-from-chronic-stress-and-depressive-symptom-induced-vascular-endothelial-dysfunction-in-female-rats-is-abolished-by-pre-existing-metabolic-disease
#19
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and that for depressive symptoms; creating a combined condition of severely elevated cardiovascular disease risk. In this companion manuscript, we determine the impact of pre-existing metabolic disease on the relationship between chronic stress//depressive symptoms and vascular function, using the obese Zucker (OZR) and the unpredictable chronic mild stress UCMS models...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451668/comparison-between-early-and-delayed-facial-nerve-decompression-in-traumatic-facial-nerve-paralysis-a-retrospective-study
#20
David Victor Kumar Irugu, Anoop Singh, Sravan Ch, Achyuth Panuganti, Anand Acharya, Hitesh Varma, Ramya Thota, Maurizio Falcioni, Sridhar Reddy
Purpose To study the intraoperative findings in case of early and delayed decompression of facial nerve paralysis and compare their results. Methods Retrospective data analysis of 23 cases of longitudinal temporal bone fracture with House-Brackmann grade V and VI facial nerve paralysis. All cases were thoroughly evaluated and underwent facial nerve decompression through the transmastoid approach. All cases were under regular follow-up till the date of manuscript submission. Results Clinical improvement of the facial nerve function was observed for early vs...
2018: CoDAS
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