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Ethanol ablation

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https://www.readbyqxmd.com/read/27867681/local-ablative-treatments-for-hepatocellular-carcinoma-an-updated-review
#1
REVIEW
Antonio Facciorusso, Gaetano Serviddio, Nicola Muscatiello
Ablative treatments currently represent the first-line option for the treatment of early stage unresectable hepatocellular carcinoma (HCC). Furthermore, they are effective as bridging/downstaging therapies before orthotopic liver transplantation. Contraindications based on size, number, and location of nodules are quite variable in literature and strictly dependent on local expertise. Among ablative therapies, radiofrequency ablation (RFA) has gained a pivotal role due to its efficacy, with a reported 5-year survival rate of 40%-70%, and safety...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27835871/comparing-the-long-term-efficacy-of-standard-and-combined-minimally-invasive-procedures-for-unresectable-hcc-a-mixed-treatment-comparison
#2
Jianghai Zhao, Hui Zhang, Lunshou Wei, Shuping Xie, Zhimin Suo
A small proportion of hepatocellular carcinoma (HCC) patients are suitable for surgical resections and various minimally invasive procedures have been introduced as alternatives to surgical resections. However, the relative efficacy of minimally invasive procedures remains to be studied in the current literature. Several popular minimally invasive procedures (monotherapy or combined therapies) were selected for comparison and their relative long-term efficacy were determined by using the statistics of hazard ratio (HR) which evaluates the survival status of HCC patients in one, two, three and four years, respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27807381/attempted-ultrasound-guided-ethanol-ablation-of-a-suspected-pancreatic-pseudocyst-in-a-dog
#3
Ryan A Sadler, Erica L Fields, Jacqueline C Whittemore
A 9-year-old, spayed female toy poodle dog developed refractory anorexia after pancreatitis. Abdominal imaging showed a cystic structure compressing the stomach. Appetite improved after percutaneous drainage of the structure, but the structure refilled within 48 h. Percutaneous ethanol ablation of the structure was attempted. Afterwards, the patient developed fatal hypotensive shock.
November 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27799963/transarterial-ethanol-ablation-combined-with-transarterial-chemoembolization-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#4
Biao Yang, Xin You, Min Lan Yuan, Tian Qiang Qin, Lin Jia Duan, Jiao He, Ze Jun Fei, Xuan Zhou, Rui Yu Zan, Zheng Yin Liao
BACKGROUND: The prognosis for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is extremely poor. OBJECTIVES: This study aimed to evaluate the safety and effectiveness of transarterial ethanol ablation (TEA) for the treatment of HCC with PVTT. METHODS: Patients were treated with TEA for PVTT under cone-beam computed tomography and traditional transarterial chemoembolization (TACE) with epirubicin for intrahepatic lesions...
August 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27797242/transarterial-chemoembolization-monotherapy-in-combination-with-radiofrequency-ablation-or-percutaneous-ethanol-injection-for-hepatocellular-carcinoma
#5
Chuan Xu, Peng-Hua Lv, Xin-En Huang, Shu-Xiang Wang, Ling Sun, Fu-An Wang
PURPOSE: To evaluate whether combined transarterial chemoembolization (TACE) with radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI) for hepatocellular carcinoma (HCC) have superior efficacy to transarterial chemoembolization (TACE) alone a retrospective review was conducted. METHODS: During January 2009 to March 2013, 108 patients with hepatocellular carcinoma underwent TACE or combined therapies (TACE+RFA or TACE+PEI). The long-term survival rates were evaluated in those patients by various statistical analyses...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27785449/hepatocellular-carcinoma-a-review
#6
REVIEW
Julius Balogh, David Victor, Emad H Asham, Sherilyn Gordon Burroughs, Maha Boktour, Ashish Saharia, Xian Li, R Mark Ghobrial, Howard P Monsour
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. In the United States, HCC is the ninth leading cause of cancer deaths. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality continue to rise. Cirrhosis remains the most important risk factor for the development of HCC regardless of etiology. Hepatitis B and C are independent risk factors for the development of cirrhosis...
2016: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/27770998/formation-of-alloy-nanoparticles-by-laser-ablation-of-au-fe-multilayer-films-in-liquid-environment
#7
Vincenzo Amendola, Stefano Scaramuzza, Francesco Carraro, Elti Cattaruzza
Laser ablation in liquids (LAL) emerged as a powerful technique for the synthesis of multielement nanoparticles (NPs) such as metal alloys with thermodynamically forbidden composition. Consequently, there is a great interest in expanding the current knowledge about NPs formation during LAL, in order to improve the control on product structure and to extend the range of compositions accessible by this technique. Here we performed a systematic investigation on alloy NPs formation by nanosecond LAL of Au/Fe/glass multilayers with different thickness and order of deposition...
October 13, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27759849/long-term-results-after-ct-guided-percutaneous-ethanol-ablation-for-the-treatment-of-hyperfunctioning-adrenal-disorders
#8
Nathan Elie Frenk, Fernando Sebastianes, Antonio Marcondes Lerario, Maria Candida Barisson Villares Fragoso, Berenice Bilharinho Mendonca, Marcos Roberto de Menezes
OBJECTIVES: To evaluate the safety and long-term efficacy of computed tomography-guided percutaneous ethanol ablation for benign primary and secondary hyperfunctioning adrenal disorders. METHOD: We retrospectively evaluated the long-term results of nine patients treated with computed tomography-guided percutaneous ethanol ablation: eight subjects who presented with primary adrenal disorders, such as pheochromocytoma, primary macronodular adrenal hyperplasia and aldosterone-producing adenoma, and one subject with Cushing disease refractory to conventional treatment...
October 1, 2016: Clinics
https://www.readbyqxmd.com/read/27752181/-total-laparoscopy-to-treat-hepatolithiasis-using-gallbladder-hepatic-duct-subcutaneous-tunnel
#9
T Li, L Cui, G Wang, X F Ling, C S Hou, L X Wang, Z Xu
To investigate the effect and feasibility of total laparoscopy to treat hepatolithiasis using gallbladder-hepatic duct subcutaneous tunnel. Retrospective analysis was conducted of the case data of 11 patients with hepatolithiasis who underwent total laparoscopic treatment using gallbladder-hepatic duct subcutaneous tunnel from January 2010 to October 2014. The operation time, blood loss, postoperative complications and recurrence of stones were recorded.All the cases completed the operation.The average hospital-stay was 9...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27701918/radiofrequency-ablation-combined-with-percutaneous-ethanol-injection-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#10
Zheng Li, Kai Zhang, Shu-Mei Lin, Deng-Hai Mi, Nong Cao, Zhi-Zhen Wen, Zhong-Xin Li
BACKGROUND: Radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) are important treatments for patients with hepatocellular carcinoma (HCC) who are not eligible for resection and liver transplantation. Therefore, it is important to establish comparisons between RFA, PEI and the two therapies in combination. AIMS: To evaluate the clinical efficacy and safety of combined RFA-PEI versus monotherapy with either RFA or PEI for HCC to provide references for clinical practice and further research...
October 5, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27688945/kappa-opioid-receptors-differentially-regulate-low-and-high-levels-of-ethanol-intake-in-female-mice
#11
Ashlee Van't Veer, Karen L Smith, Bruce M Cohen, William A Carlezon, Anita J Bechtholt
INTRODUCTION: Studies in laboratory animals and humans indicate that endogenous opioids play an important role in regulating the rewarding value of various drugs, including ethanol (EtOH). Indeed, opioid antagonists are currently a front-line treatment for alcoholism in humans. Although roles for mu- and delta-opioid receptors have been characterized, the contribution of kappa-opioid receptors (KORs) is less clear. There is evidence that changes in KOR system function can decrease or increase EtOH drinking, depending on test conditions...
September 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27670993/treatment-of-residual-facial-arteriovenous-malformations-after-embolization-with-percutaneous-cryotherapy
#12
Sean Woolen, Joseph J Gemmete
This report presents 4 patients (mean age, 22 y; range, 17-26 y) with facial arteriovenous malformations (AVMs) who underwent arterial ethanol and N-butyl cyanoacrylate embolization followed by percutaneous cryoablation of residual inaccessible AVMs. After the procedure, minor complications classified as type B according to the Society of Interventional Radiology (SIR) classification system occurred in 75% (3/4) of patients. One patient achieved 90% obliteration of AVM, and 3 patients had complete obliteration of AVM at 1-year follow-up...
October 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27667275/-long-term-outcome-and-related-predictors-of-alcohol-septal-ablation-for-patients-with-hypertrophic-obstructive-cardiomyopathy
#13
R Liu, S B Qiao, F H Hu, W X Yang, J S Yuan, J G Cui
Objective: To observe the long-term prognosis and related outcome predictors for hypertrophic obstructive cadiomyopathy (HOCM) patients underwent alcohol septal ablation (ASA). Methods: A total of 227 consecutive patients(age: (47.8±11.7) years) treated by ASA from September 2005 to December 2013 in our hospital were included and followed-up for 4.42 years(range: ( 1.17-9.93) years). Follow up rate is 97.4%(221/227). General information, medical history, data of ASA and complications during hospitalization were obtained through access to medical records of patients...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27650271/sonographic-and-cyst-fluid-cytological-changes-after-eus-guided-pancreatic-cyst-ablation
#14
Kook Hyun Kim, Kathleen McGreevy, Kristin La Fortune, Harvey Cramer, John DeWitt
BACKGROUND AND AIMS: The effect of EUS-guided pancreatic cyst ablation (PCA) on sonographic morphology and cyst fluid cytology is unknown. The aim of this study is to evaluate morphological, cytological and change in cyst fluid DNA after PCA. METHODS: In a prospective single center study, consecutive patients with suspected benign 10 to 50 mm pancreatic cysts underwent baseline EUS-FNA and EUS-PCA followed 2 to 3 months later by repeat EUS, cyst fluid analysis and possible repeat PCA...
September 17, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27649090/elevated-hypothalamic-glucocorticoid-levels-are-associated-with-obesity-and-hyperphagia-in-male-mice
#15
Charlotte Sefton, Erika Harno, Alison Davies, Helen Small, Tiffany-Jayne Allen, Jonathan R Wray, Catherine B Lawrence, Anthony P Coll, Anne White
Glucocorticoid (Gc) excess, from endogenous overproduction in disorders of the hypothalamic-pituitary-adrenal axis or exogenous medical therapy, is recognized to cause adverse metabolic side effects. The Gc receptor (GR) is widely expressed throughout the body, including brain regions such as the hypothalamus. However, the extent to which chronic Gcs affect Gc concentrations in the hypothalamus and impact on GR and target genes is unknown. To investigate this, we used a murine model of corticosterone (Cort)-induced obesity and analyzed Cort levels in the hypothalamus and expression of genes relevant to Gc action...
November 2016: Endocrinology
https://www.readbyqxmd.com/read/27642345/incidence-and-risk-factors-for-liver-abscess-after-thermal-ablation-of-liver-neoplasm
#16
Xiu-Feng Su, Na Li, Xu-Fang Chen, Lei Zhang, Ming Yan
BACKGROUND: Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most frequently used thermal ablation methods for the treatment of liver cancer. Liver abscess is a common and severe complication of thermal ablation treatment. OBJECTIVES: The objective of this study was to determine the incidence and risk factors of liver abscess formation after thermal ablation of liver cancer. MATERIALS AND METHODS: The clinical data of 423 patients who underwent 691 thermal ablation procedures for liver cancer were collected in order to retrospectively analyze the basic characteristics, incidence, and risk factors associated with liver abscess formation...
July 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27624556/nox2-amplifies-acetaldehyde-mediated-cardiomyocyte-mitochondrial-dysfunction-in-alcoholic-cardiomyopathy
#17
Moritz Brandt, Venkata Garlapati, Matthias Oelze, Efthymios Sotiriou, Maike Knorr, Swenja Kröller-Schön, Sabine Kossmann, Tanja Schönfelder, Henning Morawietz, Eberhard Schulz, Heinz-Peter Schultheiss, Andreas Daiber, Thomas Münzel, Philip Wenzel
Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the ethanol (EtOH)-metabolite acetaldehyde (ACA) is central for its development and progression, the exact mechanisms remain obscure. Murine cardiomyocytes (CMs) exposed to ACA or EtOH showed increased superoxide (O2(•-)) levels and decreased mitochondrial polarization, both being normalized by NADPH oxidase (NOX) inhibition. C57BL/6 mice and mice deficient for the ACA-degrading enzyme mitochondrial aldehyde dehydrogenase (ALDH-2(-/-)) were fed a 2% EtOH diet for 5 weeks creating an ACA-overload...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27603355/statins-improve-outcomes-of-nonsurgical-curative-treatments-in-hepatocellular-carcinoma-patients
#18
Li-Li Wu, Mao-Chih Hsieh, Jyh-Ming Chow, Shing-Hwa Liu, Chia-Lun Chang, Szu-Yuan Wu
Statins are associated with a reduced risk of hepatocellular carcinoma (HCC) and have the potential to be an adjuvant agent for HCC. In this study, we examined whether statin use is associated with additional benefits among patients who received curative treatments (CTs) such as surgery, percutaneous ethanol injection (PEI), and radiofrequency ablation (RFA).We conducted a cohort study using the Taiwan National Health Insurance Research Data linked to the Taiwan Cancer Registry in 2001 to 2012. The patient cohort consisted of those who received different treatments, and we compared patients who received statins with those who did not...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27594908/time-dependent-image-changes-after-ethanol-injection-into-the-pancreas-an-experimental-study-using-a-porcine-model
#19
Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Soichiro Fushimi, Masaya Iwamuro, Shinsuke Oda, Sho Mizukawa, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada
BACKGROUND: Ethanol, a commonly available agent, has been used to successfully ablate cystic and solid lesions in the pancreas. The aim of this study is to investigate the effects of an ethanol injection into the porcine pancreas and observe the time-dependent image changes in the pancreatic parenchyma. METHODS: Pure ethanol was injected into the pancreatic tail using a 25-gauge EUS needle with direct ultrasound guidance under celiotomy: 1 mL and 2 mL were injected, respectively...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27583865/percutaneous-ethanol-injection-therapy-is-comparable-to-radiofrequency-ablation-in-hepatocellular-carcinoma-smaller-than-1-5%C3%A2-cm-a-matched-case-control-comparative-analysis
#20
Su Jong Yu, Jung-Hwan Yoon, Jeong Min Lee, Jae Young Lee, Se Hyung Kim, Young Youn Cho, Jeong-Ju Yoo, Minjong Lee, Dong Hyeon Lee, Yuri Cho, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Although percutaneous ethanol injection therapy (PEIT) is best indicated for patients with small hepatocellular carcinoma (HCC), the survival advantage of PEIT needs confirmation in real-world practice. This study was approved by the institutional review board, and the informed consent was waived. The study included 535 consecutive patients with newly diagnosed early stage (Barcelona Clinic Liver Cancer [BCLC] 0 or A) HCC who underwent initially radiofrequency ablation (RFA) (n = 288) or PEIT (n = 247) from January 2005 to December 2010...
August 2016: Medicine (Baltimore)
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