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Ethanol ablation

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https://www.readbyqxmd.com/read/29233162/sarcomatoid-hepatocellular-carcinoma-shc-a-case-report
#1
Yingying Yu, Yanping Zhong, Jingyu Wang, Di Wu
BACKGROUND: Sarcomatoid hepatocellular carcinoma (SHC) is a rare malignant hepatic tumor. Recurrent interventional therapies such as transcatheter arterial chemo-embolization (TACE), radiofrequency ablation (RFA), and percutaneous ethanol injection have been reported previously utilized in a majority of SHC cases. To date, the exact pathogenic mechanisms underlying sarcomatoid transformation of hepatocellular carcinoma (HCC) remain unknown. CASE PRESENTATION: In this study, we report a 68-year-old female SHC patient admitted to our hospital due to discrete abdominal distention for more than 20 days...
December 12, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29225233/copper-nanoparticles-for-ascorbic-acid-sensing-in-water-on-carbon-screen-printed-electrodes
#2
Anastasiia V Shabalina, Valery A Svetlichnyi, Ksenia A Ryzhinskaya, Ivan N Lapin
A carbon screen-printed electrode was modified with copper nanoparticles from their dispersion obtained via pulsed laser ablation of a copper target in ethanol. The modified electrode exhibited activity in ascorbic acid electrochemical oxidation, giving an anodic current peak on voltammograms. Linear sweep and cyclic voltammetry have shown a linear dependence of the signal (both peak height and peak area) on the ascorbic acid concentration. The linear range from 1 to 250 μM of ascorbic acid was studied, and the detection limit was experimentally found to be 0...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29207860/therapy-of-pancreatic-neuroendocrine-tumors-fine-needle-intervention-including-ethanol-and-radiofrequency-ablation
#3
REVIEW
Sundeep Lakhtakia
Pancreatic neuroendocrine tumors (PNETs) are increasingly being detected, though usually as incidental findings. Majority of the PNETs are non-functional and surgical resection is the standard of care for most of them. However, in patients with small PNETs localized within the pancreas, who are unfit or unwilling for surgery, alternate methods of treatment are needed. Direct methods of ablation of PNETs, using either ethanol injection or radiofrequency ablation (RFA), are emerging as effective methods. The limited literature available as case reports or case series on endoscopic ultrasound (EUS)-guided local ablation using either ethanol or RFA has demonstrated safety and efficacy along with short- to medium-term sustained relief...
November 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29205458/multi-disciplinary-management-of-refractory-insulinomas
#4
Emily Brown, Daniel Watkin, Jonathan Evans, Vincent Yip, Daniel J Cuthbertson
Insulinomas are predominantly benign (~90%), pancreatic neuroendocrine tumours characterised by hyperinsulinaemic hypoglycaemia. They usually present as a small (<2cm), well demarcated, solitary nodule that can arise in any part of the organ. Treatment of sporadic insulinomas is generally aimed at curative surgical resection with special consideration in genetic syndromes. Patients with significant hypoglycaemia can pose a difficult management challenge. In isolated cases where the patient is not medically fit for surgery or with metastatic spread, other treatment options are employed...
December 4, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29141488/eus-guided-lauromacrogol-ablation-of-insulinomas-a-novel-treatment
#5
Shanyu Qin, Yongru Liu, Hongjian Ning, Lin Tao, Wei Luo, Donghong Lu, Zuojie Luo, Yingfen Qin, Jia Zhou, Junqiang Chen, Haixing Jiang
BACKGROUND AND AIMS: EUS-guided ablation with ethanol has been used to treat insulinoma since 2006 as a minimally invasive alternative for those who are unwilling or unsuitable for surgeries. However, pancreatic fistula, pancreatitis and other adverse effects were found after the procedure in these patients. Herein, we aimed to find a novel feasible injection. METHODS: Seven patients with different chief complaints were diagnosed with insulinoma by symptoms, lab results and pathology results from EUS fine needle aspiration...
November 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29126258/treatment-of-intramural-ventricular-tachycardia-in-cardiac-sarcoidosis-with-transcoronary-ethanol-ablation
#6
Steven M Markowitz, Robert M Minutello, Luke K Kim, James E Ip, George Thomas, Bruce B Lerman
No abstract text is available yet for this article.
November 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29078866/sclerotherapy-for-splenic-cysts-in-children
#7
Joseph J López, Daniel L Lodwick, Jennifer N Cooper, Mark Hogan, Denis King, Peter C Minneci
BACKGROUND: Sclerotherapy has been described as a treatment option for nonparasitic pediatric splenic cysts; however, there are limited data on its long-term effectiveness. METHODS: We performed a retrospective review and prospective follow-up imaging study of children treated for nonparasitic splenic cysts at our institution during 2006-2015. Included patients had International Classification of Disease, Ninth Revision, Clinical Modification diagnosis code 289...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29057897/alcohol-consumption-impairs-the-ependymal-cilia-motility-in-the-brain-ventricles
#8
Alzahra J Al Omran, Hannah C Saternos, Yusuf S Althobaiti, Alexander Wisner, Youssef Sari, Surya M Nauli, Wissam A AbouAlaiwi
Ependymal cilia protrude into the central canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF). Ependymal cilia dysfunction can hinder the movement of CSF leading to an abnormal accumulation of CSF within the brain known as hydrocephalus. Although the etiology of hydrocephalus was studied before, the effects of ethanol ingestion on ependymal cilia function have not been investigated in vivo. Here, we report three distinct types of ependymal cilia, type-I, type-II and type-III classified based upon their beating frequency, their beating angle, and their distinct localization within the mouse brain-lateral ventricle...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29023719/natural-variability-and-effects-of-cleaning-and-storage-procedures-on-vertebral-chemistry-of-the-blacktip-shark-carcharhinus-limbatus
#9
J P Lewis, W F Patterson, J K Carlson
Key methodological assumptions regarding the degree of natural variability and influence of sample handling and storage of elasmobranch vertebral chemistry were assessed using laser-ablation inductively coupled plasma mass spectrometry. Vertebral chemistry of juvenile blacktip sharks Carcharhinus limbatus was examined to identify whether differences existed among different regions of the vertebral column, between thoracic vertebrae of individual fish or within individual vertebrae. Additionally, the effects of bleach exposure and storage in ethanol on vertebral chemistry were compared...
October 10, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28974113/combined-radiofrequency-ablation-and-ethanol-injection-versus-repeat-hepatectomy-for-elderly-patients-with-recurrent-hepatocellular-carcinoma-after-initial-hepatic-surgery
#10
Shuling Chen, Zhenwei Peng, Han Xiao, Manxia Lin, Zebin Chen, Chunlin Jiang, Wenjie Hu, Xiaoyan Xie, Longzhong Liu, Baogang Peng, Ming Kuang
PURPOSE: To retrospectively compare the efficacy and safety of combined radiofrequency ablation and percutaneous ethanol injection (RFA-PEI) with repeat hepatectomy for elderly patients with initial recurrent hepatocellular carcinoma (HCC) after hepatic surgery. METHODS: From January 2009 to June 2015, 105 elderly patients (≥ 70 years) who underwent RFA-PEI (n = 57) or repeated hepatectomy (n = 48) for recurrent HCC ≤ 5.0 cm were included in the study...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28970243/efficacy-and-safety-of-ethanol-ablation-for-branchial-cleft-cysts
#11
E J Ha, S M Baek, J H Baek, S Y Shin, M Han, C-H Kim
BACKGROUND AND PURPOSE: Branchial cleft cyst is a common congenital lesion of the neck. This study evaluated the efficacy and safety of ethanol ablation as an alternative treatment to surgery for branchial cleft cyst. MATERIALS AND METHODS: Between September 2006 and October 2016, ethanol ablation was performed in 22 patients who refused an operation for a second branchial cleft cyst. After the exclusion of 2 patients who were lost to follow-up, the data of 20 patients were retrospectively evaluated...
September 28, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28944178/alcohol-septal-ablation-in-which-patients-and-why
#12
Paolo Spirito, Jessica Rossi, Barry J Maron
At present, surgical septal myectomy is regarded as the "gold standard" treatment for most patients with obstructive hypertrophic cardiomyopathy (HCM) and drug-refractory symptoms. However, the best results are obtained by those surgeons who have extensive experience with this operation at a small number of referral centers. In the mid-1990s, percutaneous alcohol septal ablation was introduced as an alternative to myectomy to reduce LV outflow gradient and heart failure symptoms in patients with obstructive HCM...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28940897/effects-of-sample-cleaning-and-storage-on-the-elemental-composition-of-shark-vertebrae
#13
John A Mohan, Thomas C TinHan, Nathan R Miller, R J David Wells
RATIONALE: Application of vertebral chemistry in elasmobranchs has the potential to progress our understanding of individual migration patterns and population dynamics. However, the influence of handling artifacts such as sample cleaning and storage on vertebral chemistry is unclear and requires experimental investigation. METHODS: Vertebrae centra from blacktip sharks (Carcharhinus limbatus) were cleaned with bleach (NaOCl) for five minutes (m), 1 hour (h) and 24 (h) in a cleaning experiment and stored frozen, in 70% ethanol, and 10% formalin treatments for 20 days in a storage experiment...
September 20, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28926900/-the-combination-of-percutaneous-iohexol-ethanol-injection-with-radiofrequency-ablation-for-the-treatment-of-primary-liver-cancer-in-high-risk-locations
#14
W Sun, X Y Ding, J L Chen, W D Li, X Y Wang, X D Guo, Y J Shen, S S Sun
Objective: To investigate the safety and efficacy of radiofrequency ablation (RFA) with percutaneous iohexol-ethanol injection (PIEI), compared with RFA plus transcatheter arterial chemoembolization (TACE) for patients with primary liver cancer(PLC)in high-risk locations. Methods: From January 2012 to December 2014, 54 patients with PLC in high-risk locations were enrolled. They were divided into Group A (RFA combined with PIEI) and Group B (RFA plus TACE). The efficacy and adverse events were assessed. Results: 54 patients had 74 lesions in high-risk locations...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28821832/development-of-enhanced-ethanol-ablation-as-an-alternative-to-surgery-in-treatment-of-superficial-solid-tumors
#15
Robert Morhard, Corrine Nief, Carlos Barrero Castedo, Fangyao Hu, Megan Madonna, Jenna L Mueller, Mark W Dewhirst, David F Katz, Nirmala Ramanujam
While surgery is at the foundation of cancer treatment, its access is limited in low-income countries. Here, we describe development of a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-limited settings. Although ethanol-based tumor ablation is successful in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of large fluid volumes, and decreased efficacy in treatment of non-capsulated tumors limit its applicability. To address these limitations, we investigated an enhanced ethanol ablation strategy to retain ethanol within the tumor through the addition of ethyl cellulose...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819950/successful-eus-guided-ethanol-ablation-of-insulinoma-four-year-follow-up-case-report-and-literature-review
#16
Krzysztof Dąbkowski, Paula Gajewska, Kamila Walter, Magdalena Londzin-Olesik, Andrzej Białek, Elżbieta Andrysiak-Mammos, Beata Kos-Kudła, Teresa Starzyńska
INTRODUCTION: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholic ablation, along with a literature review including 28 other previously described cases. The effectiveness, safety of the therapy, and technical procedure-related issues are summarised...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28802565/the-safety-and-efficacy-of-an-alcohol-free-pancreatic-cyst-ablation-protocol
#17
Matthew T Moyer, Setareh Sharzehi, Abraham Mathew, John M Levenick, Brandy D Headlee, Jonathan T Blandford, Heather D Heisey, James H Birkholz, Brooke B Ancrile, Jennifer L Maranki, Niraj J Gusani, Thomas J McGarrity, Charles E Dye
BACKGROUND & AIMS: Endoscopic ultrasound (EUS)-guided chemoablation with ethanol lavage followed by infusion of paclitaxel is effective for the treatment of mucinous pancreatic cysts. However, complications arise in 3%-10% of patients, presumably linked to the inflammatory effects of ethanol. We aimed to determine whether alcohol is required for effective pancreatic cyst ablation, if removing alcohol from the ablation process would improve complication rates, and whether a multi-agent chemotherapeutic cocktail could increase the rate of complete cyst resolution compared with findings reported from previous trials using alcohol followed by paclitaxel alone...
August 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28797186/ethanol-and-thermal-ablation-for-malignant-thyroid-tumours
#18
So Yeong Jeong, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid malignancy and has a good prognosis and low mortality rate. Surgery is the standard treatment for patients with primary and recurrent thyroid cancer. Although patients with PTC usually exhibit excellent treatment outcome, the incidence of recurrence in the neck ranges from 20% to 59%. When a patient with thyroid cancer is contraindicated for surgery, ultrasound (US)-guided ablation techniques, including ethanol ablation (EA) and thermal ablations, are suggested alternatives...
August 11, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28795996/initial-alpha-fetoprotein-response-predicts-prognosis-in-hepatitis-b-related-solitary-hcc-patients-after-radiofrequency-ablation
#19
Su Jong Yu, Jee Hye Kwon, Won Kim, Jung-Hwan Yoon, Jeong Min Lee, Jae Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Hwi Young Kim, Yong Jin Jung, Yoon Jun Kim
BACKGROUND: Radiofrequency ablation (RFA) is effective for early-stage hepatocellular carcinoma but recurrence is problem. GOALS: To identify prognostic factors including alpha-fetoprotein (AFP) for overall survival and intrahepatic recurrence after RFA. PATIENTS AND METHODS: Not only naïve but also previously treated patients with solitary hepatitis B virus-related hepatocellular carcinoma <5 cm were prospectively enrolled and a ≥50% decrease from baseline to 1 month after RFA was defined as an initial AFP response...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28755102/non-surgical-ablative-therapies-for-inoperable-benign-insulinoma
#20
REVIEW
C Mele, A Brunani, B Damascelli, V Tichà, L Castello, G Aimaretti, M Scacchi, P Marzullo
PURPOSE: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas. The gold-standard therapeutic approach for insulinoma is surgery, which allows for tumor removal, histology and immunochemical analyses. If surgery is not feasible, minimally invasive ablative procedures performed by interventional radiology can lead to partial or complete remission of hormone hypersecretion and tumor control in insulinoma patients. METHODS: We performed a review of existing literature on non-chemotherapeutic/radioactive ablative techniques employed for the treatment of benign, otherwise inoperable, pancreatic insulinoma...
July 28, 2017: Journal of Endocrinological Investigation
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