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https://www.readbyqxmd.com/read/29742738/percutaneous-cholecystostomy-for-high-risk-patients-with-acute-cholangitis
#1
Yan-Lin Li, Kin-Hoi Wong, Keith Wan-Hang Chiu, Andrew Kai-Chun Cheng, Ronald Kin-On Cheung, Max Kai-Ho Yam, Angie Lok-Chi Chan, Victor Siang-Hua Chan, Martin Wai-Ming Law, Paul Sing-Fun Lee
Percutaneous cholecystostomy (PC) is a well-established treatment for acute cholecystitis. We investigate the performance and role of PC in managing acute cholangitis.Retrospective review on all patients who underwent PC for acute cholangitis between January 2012 and June 2017 at a major regional hospital in Hong Kong.Thirty-two patients were included. The median age was 84 years and median American Society of Anaesthesiologists (ASA) physical status was Class III (severe systemic disease). All fulfilled Tokyo Guidelines 2013 (TG13) diagnostic criteria for moderate or severe cholangitis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29720903/colorectal-cancer-in-inflammatory-bowel-disease
#2
REVIEW
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29691599/-primary-biliary-cholangitis-established-and-novel-therapies
#3
REVIEW
M Vetter, A E Kremer
BACKGROUND: Patients with primary biliary cholangitis (PBC, formerly primary biliary cirrhosis) and insufficient treatment response or risk factors exhibit a remarkably increased risk for disease progression and associated complications. Furthermore, extrahepatic manifestations may considerably reduce quality of life in affected patients. OBJECTIVES: This article presents an overview on standard therapy with ursodeoxycholic acid (UDCA) and further therapeutic options in patients with insufficient treatment response...
April 24, 2018: Der Internist
https://www.readbyqxmd.com/read/29657606/early-biliary-drainage-is-associated-with-favourable-outcomes-in-critically-ill-patients-with-acute-cholangitis
#4
Mohammed Aboelsoud, Osama Siddique, Alexander Morales, Young Seol, Mazen Al-Qadi
Introduction: Acute cholangitis (AC) is a clinical condition that requires prompt medical management with IV fluids, antibiotics, and biliary drainage (BD). The optimal timing for BD remains unclear. Aim: To investigate the effect of biliary drainage timing on clinical outcomes in AC. Material and methods: We conducted a retrospective study of patients with AC admitted to the ICU using the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#5
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29593060/the-british-society-of-gastroenterology-uk-pbc-primary-biliary-cholangitis-treatment-and-management-guidelines
#6
Gideon M Hirschfield, Jessica K Dyson, Graeme J M Alexander, Michael H Chapman, Jane Collier, Stefan Hübscher, Imran Patanwala, Stephen P Pereira, Collette Thain, Douglas Thorburn, Dina Tiniakos, Martine Walmsley, George Webster, David E J Jones
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are presumed relevant to disease initiation. PBC is most prevalent in women and those over the age of 50, but a spectrum of disease is recognised in adult patients globally; male sex, younger age at onset (<45) and advanced disease at presentation are baseline predictors of poorer outcome...
March 28, 2018: Gut
https://www.readbyqxmd.com/read/29554146/evaluation-of-classical-and-novel-autoantibodies-for-the-diagnosis-of-primary-biliary-cholangitis-autoimmune-hepatitis-overlap-syndrome-pbc-aih-os
#7
Henry H Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J Urbanski, Andrew L Mason, Gary L Norman, Marvin J Fritzler, Mark G Swain
BACKGROUND AND AIMS: Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH overlap syndrome (PBC-AIH OS) have been reported to exhibit suboptimal responses to ursodeoxycholic acid therapy, and are more likely to progress to cirrhosis. Anti-double stranded DNA (anti-dsDNA) and anti-p53 have been previously suggested to be potential autoantibodies for identifying patients with PBC-AIH OS...
2018: PloS One
https://www.readbyqxmd.com/read/29511408/worsening-of-acute-cholangitis-caused-by-a-bile-duct-stone-after-hospitalization-a-case-series
#8
Tetsuro Akashi, Yuichi Tachibana, Susumu Matsuo, Junya Gibo
Acute cholangitis is a fatal condition if inadequately treated. It is possible to underestimate the severity of the condition because bacterial cultures are not immediately available. We evaluated the clinical features of patients with cholangitis due to bile duct stones who were diagnosed with severe bacteremia at the time of hospitalization, but not at the time of the initial visit. We conducted a retrospective analysis of cases of endoscopic retrograde cholangiopancreatography performed between January 2007 and October 2011 in patients with bile duct stones complicated by cholangitis...
February 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29401491/urgent-endoscopic-retrograde-cholangiopancreatography-is-not-superior-to-early-ercp-in-acute-biliary-pancreatitis-with-biliary-obstruction-without-cholangitis
#9
Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Jae Bock Chung
Acute pancreatitis is a common diagnosis worldwide, with gallstone disease being the most prevalent cause (50%). The American College of Gastroenterology recommends urgent endoscopic retrograde cholangiopancreatography (ERCP) (within 24 h) for patients with biliary pancreatitis accompanied by cholangitis. Most international guidelines recommend that ERCP be performed within 72 h in patients with biliary pancreatitis and a bile duct obstruction without cholangitis, but the optimal timing for endoscopy is controversial...
2018: PloS One
https://www.readbyqxmd.com/read/29374984/clinical-applicability-of-tokyo-guidelines-2018-2013-in-diagnosis-and-severity-evaluation-of-acute-cholangitis-and-determination-of-a-new-severity-model
#10
Elisa Gravito-Soares, Marta Gravito-Soares, Dário Gomes, Nuno Almeida, Luís Tomé
OBJECTIVE: To determine the diagnostic accuracy of Tokyo guidelines (TG) 2018/2013 (TG18/TG13) and predictors of poor prognosis in acute cholangitis. METHODS: Retrospective 1-year study of consecutive hospital admissions for acute cholangitis. Prognosis was defined in terms of 30 d in-hospital mortality. RESULTS: Of the 183 patients with acute cholangitis, diagnostic accuracy based on Charcot's triad, TG07 and TG18/TG13 was 67.8, 86.9 and 92...
March 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29334699/tokyo-guidelines-2018-updated-tokyo-guidelines-for-the-management-of-acute-cholangitis-acute-cholecystitis
#11
EDITORIAL
Tadahiro Takada
No abstract text is available yet for this article.
January 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29325274/-an-interpretation-of-2017-easl-clinical-practice-guidelines-the-diagnosis-and-management-of-patients-with-primary-biliary-cholangitis
#12
Y Han, Y Chen
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic disease and may progress to liver fibrosis, liver cirrhosis, decompensated cirrhosis, and even end-stage liver disease without effective treatment. The diagnosis of PBC is mainly based on the biochemical parameters indicating cholestatic hepatitis and the presence of specific autoantibody in circulation. The goals of the treatment and management of PBC are to prevent the development of end-stage liver disease, to improve related clinical symptoms, and to improve patients' quality of life...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29273876/surgeon-performed-endoscopic-retrograde-cholangiopancreatography-outcomes-of-2392-procedures-at-two-tertiary-care-centers
#13
Mazen R Al-Mansour, Eleanor C Fung, Edward L Jones, Nichole E Zayan, Timothy D Wetzel, Sara E Martin Del Campo, Anahita D Jalilvand, Andrew J Suzo, Rebecca R Dettorre, James K Fullerton, Michael P Meara, John D Mellinger, Vimal K Narula, Jeffrey W Hazey
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is a common procedure that, in the United States, is traditionally performed by gastroenterologists. We hypothesized that when performed by well-trained surgeons, ERCP can be performed safely and effectively. The objectives of the study were to assess the rate of successful cannulation of the duct of interest and to assess the 30-day complication and mortality rates. METHODS: We retrospectively reviewed the charts of 1858 patients who underwent 2392 ERCP procedures performed by five surgeons between August 2003 and June 2016 in two centers...
December 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29152767/development-and-validation-of-a-primary-sclerosing-cholangitis-specific-patient-reported-outcomes-instrument-the-psc-pro
#14
Zobair M Younossi, Arian Afendy, Maria Stepanova, Andrei Racila, Fatema Nader, Rachel Gomel, Ricky Safer, William R Lenderking, Anne Skalicky, Leah Kleinman, Robert P Myers, G Mani Subramanian, John G McHutchison, Cynthia Levy, Christopher L Bowlus, Kris Kowdley, Andrew J Muir
BACKGROUND: PSC is a chronic liver disease associated with inflammation and biliary fibrosis that leads to cholangitis, cirrhosis, and impaired quality of life. Our objective was to develop and validate a PSC-specific PRO instrument. METHODS: We developed a 42-item PSC PRO instrument that contains 2 modules (Symptoms and Impact of Symptoms), and conducted external validation. Reliability and validity were evaluated using clinical data and a battery of other validated instruments...
November 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29090868/tokyo-guidelines-2018-management-bundles-for-acute-cholangitis-and-cholecystitis
#15
LETTER
Toshihiko Mayumi, Kohji Okamoto, Tadahiro Takada, Steven M Strasberg, Joseph S Solomkin, David Schlossberg, Henry A Pitt, Masahiro Yoshida, Harumi Gomi, Fumihiko Miura, O James Garden, Seiki Kiriyama, Masamichi Yokoe, Itaru Endo, Horacio J Asbun, Yukio Iwashita, Taizo Hibi, Akiko Umezawa, Kenji Suzuki, Takao Itoi, Jiro Hata, Ho-Seong Han, Tsann-Long Hwang, Christos Dervenis, Koji Asai, Yasuhisa Mori, Wayne Shih-Wei Huang, Giulio Belli, Shuntaro Mukai, Palepu Jagannath, Daniel Cherqui, Kazuto Kozaka, Todd H Baron, Eduardo de Santibañes, Ryota Higuchi, Keita Wada, Dirk J Gouma, Daniel J Deziel, Kui-Hin Liau, Go Wakabayashi, Robert Padbury, Eduard Jonas, Avinash Nivritti Supe, Harjit Singh, Toshifumi Gabata, Angus C W Chan, Wan Yee Lau, Sheung Tat Fan, Miin-Fu Chen, Chen-Guo Ker, Yoo-Seok Yoon, In-Seok Choi, Myung-Hwan Kim, Dong-Sup Yoon, Seigo Kitano, Masafumi Inomata, Koichi Hirata, Kazuo Inui, Yoshinobu Sumiyama, Masakazu Yamamoto
Management bundles that define items or procedures strongly recommended in clinical practice have been used in many guidelines in recent years. Application of these bundles facilitates the adaptation of guidelines and helps improve the prognosis of target diseases. In Tokyo Guidelines 2013 (TG13), we proposed management bundles for acute cholangitis and cholecystitis. Here, in Tokyo Guidelines 2018 (TG18), we redefine the management bundles for acute cholangitis and cholecystitis. Critical parts of the bundles in TG18 include the diagnostic process, severity assessment, transfer of patients if necessary, and therapeutic approach at each time point...
January 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29090866/tokyo-guidelines-2018-antimicrobial-therapy-for-acute-cholangitis-and-cholecystitis
#16
LETTER
Harumi Gomi, Joseph S Solomkin, David Schlossberg, Kohji Okamoto, Tadahiro Takada, Steven M Strasberg, Tomohiko Ukai, Itaru Endo, Yukio Iwashita, Taizo Hibi, Henry A Pitt, Naohisa Matsunaga, Yoriyuki Takamori, Akiko Umezawa, Koji Asai, Kenji Suzuki, Ho-Seong Han, Tsann-Long Hwang, Yasuhisa Mori, Yoo-Seok Yoon, Wayne Shih-Wei Huang, Giulio Belli, Christos Dervenis, Masamichi Yokoe, Seiki Kiriyama, Takao Itoi, Palepu Jagannath, O James Garden, Fumihiko Miura, Eduardo de Santibañes, Satoru Shikata, Yoshinori Noguchi, Keita Wada, Goro Honda, Avinash Nivritti Supe, Masahiro Yoshida, Toshihiko Mayumi, Dirk J Gouma, Daniel J Deziel, Kui-Hin Liau, Miin-Fu Chen, Keng-Hao Liu, Cheng-Hsi Su, Angus C W Chan, Dong-Sup Yoon, In-Seok Choi, Eduard Jonas, Xiao-Ping Chen, Sheung Tat Fan, Chen-Guo Ker, Mariano Eduardo Giménez, Seigo Kitano, Masafumi Inomata, Shuntaro Mukai, Ryota Higuchi, Koichi Hirata, Kazuo Inui, Yoshinobu Sumiyama, Masakazu Yamamoto
Antimicrobial therapy is a mainstay of the management for patients with acute cholangitis and/or cholecystitis. The Tokyo Guidelines 2018 (TG18) provides recommendations for the appropriate use of antimicrobials for community-acquired and healthcare-associated infections. The listed agents are for empirical therapy provided before the infecting isolates are identified. Antimicrobial agents are listed by class-definitions and TG18 severity grade I, II, and III subcategorized by clinical settings. In the era of emerging and increasing antimicrobial resistance, monitoring and updating local antibiograms is underscored...
January 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29089703/evaluation-and-comparison-of-charcot-s-triad-and-tokyo-guidelines-for-the-diagnosis-of-acute-cholangitis
#17
Tolga Dinc, Selami Ilgaz Kayilioglu, Faruk Coskun
Reliability of Charcot's triad has long been questioned. Tokyo Guidelines committee published Tokyo Guidelines in 2007 and 2013. The aim of this study was to retrospectively examine the patients who had been treated with the diagnosis of acute cholangitis and evaluate 2007-2013 Tokyo criteria and Charcot's triad. The files of the patients with acute cholangitis in a referral center were examined retrospectively. All patients were classified and evaluated according to 2007 and 2013 Tokyo criteria and Charcot's triad; and results were compared...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29032636/tokyo-guidelines-2018-diagnostic-criteria-and-severity-grading-of-acute-cholecystitis-with-videos
#18
LETTER
Masamichi Yokoe, Jiro Hata, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Go Wakabayashi, Kazuto Kozaka, Itaru Endo, Daniel J Deziel, Fumihiko Miura, Kohji Okamoto, Tsann-Long Hwang, Wayne Shih-Wei Huang, Chen-Guo Ker, Miin-Fu Chen, Ho-Seong Han, Yoo-Seok Yoon, In-Seok Choi, Dong-Sup Yoon, Yoshinori Noguchi, Satoru Shikata, Tomohiko Ukai, Ryota Higuchi, Toshifumi Gabata, Yasuhisa Mori, Yukio Iwashita, Taizo Hibi, Palepu Jagannath, Eduard Jonas, Kui-Hin Liau, Christos Dervenis, Dirk J Gouma, Daniel Cherqui, Giulio Belli, O James Garden, Mariano Eduardo Giménez, Eduardo de Santibañes, Kenji Suzuki, Akiko Umezawa, Avinash Nivritti Supe, Henry A Pitt, Harjit Singh, Angus C W Chan, Wan Yee Lau, Anthony Yuen Bun Teoh, Goro Honda, Atsushi Sugioka, Koji Asai, Harumi Gomi, Takao Itoi, Seiki Kiriyama, Masahiro Yoshida, Toshihiko Mayumi, Naoki Matsumura, Hiromi Tokumura, Seigo Kitano, Koichi Hirata, Kazuo Inui, Yoshinobu Sumiyama, Masakazu Yamamoto
The Tokyo Guidelines 2013 (TG13) for acute cholangitis and cholecystitis were globally disseminated and various clinical studies about the management of acute cholecystitis were reported by many researchers and clinicians from all over the world. The 1st edition of the Tokyo Guidelines 2007 (TG07) was revised in 2013. According to that revision, the TG13 diagnostic criteria of acute cholecystitis provided better specificity and higher diagnostic accuracy. Thorough our literature search about diagnostic criteria for acute cholecystitis, new and strong evidence that had been released from 2013 to 2017 was not found with serious and important issues about using TG13 diagnostic criteria of acute cholecystitis...
January 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29032610/tokyo-guidelines-2018-diagnostic-criteria-and-severity-grading-of-acute-cholangitis-with-videos
#19
LETTER
Seiki Kiriyama, Kazuto Kozaka, Tadahiro Takada, Steven M Strasberg, Henry A Pitt, Toshifumi Gabata, Jiro Hata, Kui-Hin Liau, Fumihiko Miura, Akihiko Horiguchi, Keng-Hao Liu, Cheng-Hsi Su, Keita Wada, Palepu Jagannath, Takao Itoi, Dirk J Gouma, Yasuhisa Mori, Shuntaro Mukai, Mariano Eduardo Giménez, Wayne Shih-Wei Huang, Myung-Hwan Kim, Kohji Okamoto, Giulio Belli, Christos Dervenis, Angus C W Chan, Wan Yee Lau, Itaru Endo, Harumi Gomi, Masahiro Yoshida, Toshihiko Mayumi, Todd H Baron, Eduardo de Santibañes, Anthony Yuen Bun Teoh, Tsann-Long Hwang, Chen-Guo Ker, Miin-Fu Chen, Ho-Seong Han, Yoo-Seok Yoon, In-Seok Choi, Dong-Sup Yoon, Ryota Higuchi, Seigo Kitano, Masafumi Inomata, Daniel J Deziel, Eduard Jonas, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
Although the diagnostic and severity grading criteria on the 2013 Tokyo Guidelines (TG13) are used worldwide as the primary standard for management of acute cholangitis (AC), they need to be validated through implementation and assessment in actual clinical practice. Here, we conduct a systematic review of the literature to validate the TG13 diagnostic and severity grading criteria for AC and propose TG18 criteria. While there is little evidence evaluating the TG13 criteria, they were validated through a large-scale case series study in Japan and Taiwan...
January 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28941329/tokyo-guidelines-2018-initial-management-of-acute-biliary-infection-and-flowchart-for-acute-cholangitis
#20
LETTER
Fumihiko Miura, Kohji Okamoto, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Henry A Pitt, Harumi Gomi, Joseph S Solomkin, David Schlossberg, Ho-Seong Han, Myung-Hwan Kim, Tsann-Long Hwang, Miin-Fu Chen, Wayne Shih-Wei Huang, Seiki Kiriyama, Takao Itoi, O James Garden, Kui-Hin Liau, Akihiko Horiguchi, Keng-Hao Liu, Cheng-Hsi Su, Dirk J Gouma, Giulio Belli, Christos Dervenis, Palepu Jagannath, Angus C W Chan, Wan Yee Lau, Itaru Endo, Kenji Suzuki, Yoo-Seok Yoon, Eduardo de Santibañes, Mariano Eduardo Giménez, Eduard Jonas, Harjit Singh, Goro Honda, Koji Asai, Yasuhisa Mori, Keita Wada, Ryota Higuchi, Manabu Watanabe, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Akiko Umezawa, Shuntaro Mukai, Hiromi Tokumura, Jiro Hata, Kazuto Kozaka, Yukio Iwashita, Taizo Hibi, Masamichi Yokoe, Taizo Kimura, Seigo Kitano, Masafumi Inomata, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
The initial management of patients with suspected acute biliary infection starts with the measurement of vital signs to assess whether or not the situation is urgent. If the case is judged to be urgent, initial medical treatment should be started immediately including respiratory/circulatory management if required, without waiting for a definitive diagnosis. The patient's medical history is then taken; an abdominal examination is performed; blood tests, urinalysis, and diagnostic imaging are carried out; and a diagnosis is made using the diagnostic criteria for cholangitis/cholecystitis...
January 2018: Journal of Hepato-biliary-pancreatic Sciences
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