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https://www.readbyqxmd.com/read/29667749/effect-of-lysm-macrophage-depletion-on-lung-pathology-in-mice-with-chronic-bronchitis
#1
Yogesh Saini, Brandon W Lewis, Dongfang Yu, Hong Dang, Alessandra Livraghi-Butrico, Fabio Del Piero, Wanda K O'Neal, Richard C Boucher
Macrophages (MΦ) are key sentinels of respiratory exposure to inhaled environmental stimuli. In normal "healthy" tissues, MΦ are believed to be a dormant cell type that, upon exposure to stress-causing stimuli, may get activated to exhibit pro- or anti-inflammatory roles. To test whether stress present in chronic bronchitic (CB) airways triggers MΦ to manifest protective or detrimental responses, the DTA+ (LysM-regulated Diphtheria Toxin A expressing) strain with partial MΦ-deficiency was crossed with the Scnn1b-Tg mouse model of CB and the progenies were studied at 4-5 weeks of age...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29667549/dentification-and-quantification-of-quercetin-a-major-consitituent-of-artocarpus-altilis-by-targeting-related-genes-of-apoptosis-and-cell-cycle-in-vitro-cytotoxic-activity-against-human-lung-carcinoma-cell-lines-a549
#2
Silvana Russo, Walter Filgueira De Azevedo
BACKGROUND: Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in the central nervous system, whose crystallographic structure has recently been solved. Studies will be needed to investigate CB1 complexes with its ligands and its role in the development of new drugs. OBJECTIVE: Our goal here is to review the studies on CB1, starting with general aspects and focusing on the recent structural studies, with emphasis on the inverse agonists bound structures...
April 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29663607/dynamic-interfacial-adhesion-through-cucurbit-n-uril-molecular-recognition
#3
Ji Liu, Cindy Soo Yun Tan, Oren A Scherman
Supramolecular building block, such as cucurbit[n]uril (CB[n])-based host-guest complexes, have been extensively studied at the nano- and microscale as adhesion promoters. Herein, we exploit a new class of CB[n]-threaded highly-branched polyrotaxanes (HBP-CB[n]) as aqueous adhesives to macroscopically bond two wet surfaces, including biological tissue, through the formation of CB[8] heteroternary complexes. The dynamic nature of these complexes gives rise to adhesion with remarkable self-healing, displaying recovery and re-adhesion after mechanical failure at the interface...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29662900/analysis-of-the-clinicopathological-characteristics-and-risk-factors-in-patients-with-lung-cancer-and-chronic-obstructive-pulmonary-disease
#4
Jian-Long Miao, Jing-Jing Cai, Xiao-Feng Qin, Rui-Juan Liu
Objective: To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods: We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smoking status, and histologic type was obtained from medical records. Results: Lung cancer patients with COPD and those with the chronic bronchitis (CB) phenotype had higher smoking indices compared to those without COPD (723...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661301/antifouling-zwitterionic-dextran-micelles-for-efficient-loading-dox
#5
Xiaotian Wu, Xiaofeng Chen, Peibo Hu, Minghong Hou, Yahao Dong, Yuping Wei
Polysaccharides derivatives are typical drug nanocarriers which are nontoxic and biodegradable. However, as is the case for all drug delivery systems, polysaccharides derivatives have to face the issue of protein fouling. In this paper, we present the design and synthesis of carboxybetaine-modified dextran-polycaprolactone (CB-Dex-PCL) copolymers as doxorubicin (DOX) nanocarriers. Results showed that DOX/CB-Dex-PCL micelles exhibited better cumulative release at the pH value of 5.2 than at the physiological pH of 7...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29660869/dysregulation-of-major-functional-genes-in-frontal-cortex-by-maternal-exposure-to-carbon-black-nanoparticle-is-not-ameliorated-by-ascorbic-acid-pretreatment
#6
Atsuto Onoda, Ken Takeda, Masakazu Umezawa
Recent cohort studies have revealed that perinatal exposure to particulate air pollution, including carbon-based nanoparticles, increases the risk of brain disorders. Although developmental neurotoxicity is currently a major issue in the toxicology of nanoparticles, critical information for understanding the mechanisms underlying the developmental neurotoxicity of airway exposure to carbon black nanoparticle (CB-NP) is still lacking. In order to investigate these mechanisms, we comprehensively analyzed fluctuations in the gene expression profile of the frontal cortex of offspring mice exposed maternally to CB-NP, using microarray analysis combined with Gene Ontology information...
April 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660456/chitosan-based-hydrogels-preparation-properties-and-applications
#7
Zahra Shariatinia, Azin Mazloom Jalali
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29660452/simulation-of-non-inherited-maternal-antigens-acceptable-hla-mismatches-to-increase-the-chance-of-matched-cord-blood-units-hong-kong-s-experience
#8
Janette Kwok, Mengbiao Guo, Wanling Yang, Patrick Ip, C K Lee, Liwei Lu, Godfrey C F Chan, Derek Middleton, Henk G M van der Zanden
In Cord blood transplantation (CBT), the non-inherited maternal antigen (NIMA) virtual six HLA matched CB is found to have similar outcomes to six HLA inherited matched CB. Such virtual HLA matched CB units can be generated by substituting the inherited alleles with one to three NIMAs. In Hong Kong Cord Blood Bank, CB units have no NIMA defined. 100 CB samples were collected with NIMA defined. Retrospective searches of Hong Kong patients (n = 520) were matched against the inherited and virtual HLA phenotypes of NIMA CB file...
April 13, 2018: Human Immunology
https://www.readbyqxmd.com/read/29658111/architectonic-characteristics-of-the-visual-thalamus-and-superior-colliculus-in-titi-monkeys
#9
Mary Kl Baldwin, Leah Krubitzer
Titi monkeys are arboreal, diurnal New World monkeys whose ancestors were the first surviving branch of the New World radiation. In the current study, we use cytoarchtectonic and immunohistochemical characteristics to compare subcortical structures associated with visual processing with those of other well-studied primates. Our goal was to appreciate features that are similar across all New World monkeys, and primates in general, versus those features that are unique to titi monkeys and other primate taxa. We examined tissue stained for Nissl substance, cytochrome oxidase (CO), acetylcholinesterase (AChE), calbindin (Cb), parvalbumin (Pv), and vesicular glutamate transporter 2 (VGLUT2) to characterize the superior colliculus, lateral geniculate nucleus, and visual pulvinar...
April 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29657591/the-lesion-characteristics-assessed-by-lge-mri-after-the-cryoballoon-ablation-and-conventional-radiofrequency-ablation
#10
Jun Kurose, Kunihiko Kiuchi, Koji Fukuzawa, Shumpei Mori, Hirotoshi Ichibori, Hiroki Konishi, Yayoi Taniguchi, Kiyohiro Hyogo, Hiroshi Imada, Hideya Suehiro, Yu-Ichi Nagamatsu, Tomomi Akita, Makoto Takemoto, Ken-Ichi Hirata, Shinsuke Shimoyama, Yoshiaki Watanabe, Tatsuya Nishii, Noriyuki Negi, Katsusuke Kyotani
Background: Rhythm outcomes after the pulmonary vein isolation (PVI) using the cryoballoon (CB) are reported to be excellent. However, the lesions after CB ablation have not been well discussed. We sought to characterize and compare the lesion formation after CB ablation with that after radiofrequency (RF) ablation. Methods: A total of 42 consecutive patients who underwent PVI were enrolled (29 in the CB group and 13 in the RF group). The PVI lesions were assessed by late gadolinium enhancement magnetic resonance imaging 1-3 months after the PVI...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29651959/central-to-peripheral-arterial-stiffness-gradient-in-hemodialyzed-patients-depends-on-the-location-of-the-upper-limb-vascular-access
#11
Daniel Bia, Cintia Galli, Yanina Zocalo, Rodolfo Valtuille, Sandra Wray, Franco Pessana, Edmundo I Cabrera-Fischer
Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained in the side of the body where the VA was placed and compare them to its contralateral intact side...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651351/acquired-von-willebrand-disease-associated-with-mantle-cell-lymphoma
#12
Dominique Maas, Britta Laros-van Gorkom, Sanne Gianotten, Marjan Cruijsen, Waander van Heerde, Marten Nijziel
We present a rare case of acquired von Willebrand syndrome (AVWS) caused by a mantle cell lymphoma. A 61-year-old male suffered from recurrent bleeding symptoms since a few months. Initially, physical examination was normal. von Willebrand factor antigen (VWF:Ag) level and factor VIII activity (FVIII:C) were low (0.31 IU/ml and 0.43 IU/ml, resp.). Ristocetin cofactor activity (VWF:RCo) was 0.09 IU/ml, and collagen binding activity (VWF:CB) was 0.10 IU/ml. VWF:RCo/VWF:Ag ratio was 0.29, and RIPA value was normal...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29651180/production-of-a-mixture-of-fengycins-with-surfactant-and-antifungal-activities-by-bacillus-sp-ma04-a-versatile-pgpr
#13
Alejandro Hernández-Morales, Ramón-Alvar Martínez-Peniche, Jackeline-Lizzeta Arvizu-Gómez, Sofía-María Arvizu-Medrano, Areli Rodríguez-Ontiveros, Miguel-Angel Ramos-López, Juan-Ramiro Pacheco-Aguilar
Bacillus sp. strain MA04 a plant growth-promoting rhizobacteria (PGPR) showed hemolytic activity on blood agar plates, and the supernatant from liquid culture in nutrient broth at 24 h exhibited emulsification activity, suggesting the production of biosurfactants. In antagonist assays, the supernatant showed antifungal activity against phytopathogenic fungi such as Penicillium expansum , Fusarium stilboides , Sclerotium rolfsii y Rhizoctonia solani , finding a reduction of mycelial growth of all fungi tested, ranging from 35 to 69%, this activity was increased with time of culture, accomplishing percentages of inhibition up to 85% with supernatants obtained at 72 h...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29651095/validation-of-ultrasound-bioimaging-to-predict-worm-burden-and-treatment-efficacy-in-preclinical-filariasis-drug-screening-models
#14
Amy E Marriott, Hanna Sjoberg, Hayley Tyrer, Joanne Gamble, Emma Murphy, John Archer, Andrew Steven, Mark J Taylor, Joseph D Turner
Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. The incidence of infection failures and high intra-group variation means that large group sizes are required for drug testing. Further, a lack of accurate, quantitative adult biomarkers results in protracted timeframes or multiple groups for endpoint analyses. Here we evaluate intra-vital ultrasonography (USG) to identify B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650039/carbon-black-suppresses-the-osteogenesis-of-mesenchymal-stem-cells-the-role-of-mitochondria
#15
Yulai Shen, Lu Wu, Dongdong Qin, Yankai Xia, Zhu Zhou, Xuemei Zhang, Xin Wu
BACKGROUND: The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an important role in the osteogenesis of MSCs and are potential targets of nanomaterials, so we studied the role of mitochondria in the CB Printex 90-induced effects on osteogenesis. RESULTS: Low doses of Printex 90 (3 ng/mL and 30 ng/mL) that did not cause deleterious effects on MSCs' viability significantly inhibited osteogenesis of MSCs...
April 12, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29648598/a-new-brief-measure-of-executive-function-adapting-the-head-toes-knees-shoulders-task-to-older-adults
#16
Eric S Cerino, Karen Hooker, Robert S Stawski, Megan McClelland
Background and Objectives: Executive function (EF) abilities are recognized as components of cognition most likely to show age-related declines. Measurement of EF in older adults is often computer-based, takes place in a laboratory setting, and thus lacks ecological validity. We sought to investigate a new way of measuring EF in older adults by adapting a brief, behavioral measure of EF in children, the Head-Toes-Knees-Shoulders task (HTKS). Research Design and Methods: A sample of 150 community-dwelling older adults (Mean age = 68...
April 10, 2018: Gerontologist
https://www.readbyqxmd.com/read/29645283/sympathoexcitation-following-intermittent-hypoxia-in-rat-is-mediated-by-circulating-angiotensin-ii-acting-at-the-carotid-body-and-subfornical-organ
#17
Seung Jae Kim, Angelina Y Fong, Paul M Pilowsky, Stephen B G Abbott
Circulating angiotensin II (AngII) is vital for arterial pressure elevation following intermittent hypoxia in rats, but its importance in the induction of sympathetic changes is unclear. We tested the contribution of the RAS to the effects of acute intermittent hypoxia (AIH) in anaesthetized ventilated adult rats. AIH caused a 33.7 ± 2.9% increase in sympathetic nerve activity (SNA), and a one-fold increase in sympathetic peripheral chemoreflex sensitivity and central sympathetic-respiratory coupling. The sympathetic effects of AIH were prevented by blocking angiotensin type 1 receptors with systemic losartan and intermittent systemic injections of AngII (Int...
April 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29644773/highly-efficient-supramolecular-catalysis-by-endowing-the-reaction-intermediate-with-adaptive-reactivity
#18
Yang Jiao, Bohan Tang, Yucheng Zhang, Jiang-Fei Xu, Zhiqiang Wang, Xi Zhang
A new strategy of highly efficient supramolecular catalysis is developed by endowing the reaction intermediate with adaptive reactivity. The supramolecular catalyst, prepared by the host-guest complexation between 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) and cucubit[7]uril (CB[7]), was used for biphasic oxidation of alcohols. Cationic TEMPO+, the key intermediate, was stabilized by the electrostatic effect of CB[7] in aqueous phase, thus promoting the formation of TEMPO+ and inhibiting side reactions. Moreover, through the migration into organic phase, TEMPO+ was separated from CB[7] and recovered the high reactivity to drive a fast oxidation of substrates...
April 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29644713/deuterium-substituted-2-2-dimethylamino-methyl-4-18-f-fluoropropoxy-phenyl-thio-benzenamine-as-a-serotonin-transporter-imaging-agent
#19
Futao Liu, Lin Zhu, Seok Rye Choi, Karl Plössl, Zhihao Zha, Hank F Kung
Positron emission tomography (PET) imaging of serotonin transporter (SERT) is useful for studying brain diseases with altered serotonergic function. A deuterated imaging agent, ([18 F]2-((2-((bis(methyl-d3)amino)methyl)-4-(3-fluoropropoxy- 1,1,2,2,3,3-d6)phenyl)thio)aniline, [18 F]D12FPBM, [18 F]1), was prepared as a new chemical entity (NCE). The deuterated agent, 1, showed excellent binding affinity to SERT; Ki was 0.086 nM, comparable to the un-deuterated FPBM. In vivo biodistribution studies in rats with [18 F]1 showed good brain uptake (1...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29643652/utility-of-cytokeratin7-immunocytochemistry-in-the-cytopathological-diagnosis-of-fibrolamellar-hepatocellular-carcinoma
#20
Rashi Garg, Radhika Srinivasan, Pranab Dey, Priya Singh, Nalini Gupta, Arvind Rajwanshi
Objective: To distinguish fibrolamellar hepatocellular carcinoma (FL-HCC) variant from the conventional hepatocellular carcinoma (HCC) by cytology, immunocytochemistry, and morphometry. Study Design: Retrospective detailed cytomorphological, immunocytochemical, and morphometric analysis was performed in 6 cases of FL-HCC reported on fine needle aspiration. Cell block immunocytochemistry (CB-ICC) for CK7 and CD68 was performed in four cases. Morphometry was carried out with Cell A software...
April 2018: Journal of Cytology
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