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https://www.readbyqxmd.com/read/29049968/a-novel-eulerian-approach-for-modelling-cyanobacteria-movement-thin-layer-formation-and-recurrent-risk-to-drinking-water-intakes
#1
Mouhamed Ndong, David Bird, Tri Nguyen Quang, René Kahawita, David Hamilton, Marie Laure de Boutray, Michèle Prévost, Sarah Dorner
Toxic cyanobacteria (CB) blooms are being reported in an increasing number of water bodies worldwide. As drinking water (DW) treatment can be disrupted by CB, in addition to long term management plans, short term operational decision-making tools are needed that enable an understanding of the temporal variability of CB movement in relation to drinking water intakes. In this paper, we propose a novel conservative model based on a Eulerian framework and compare results with data from CB blooms in Missisquoi Bay (Québec, Canada)...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29048713/cucurbit-7-uril-as-a-supramolecular-artificial-enzyme-for-diels-alder-reactions
#2
Aniello Palma, Markus Artelsmair, Guanglu Wu, Xiaoyong Lu, Steven J Barrow, Najib Uddin, Edina Rosta, Eric Masson, Oren A Scherman
The ability to mimic the activity of natural enzymes using supramolecular constructs (artificial enzymes) represents a vibrant scientific research field. Herein, we demonstrate that cucurbit[7]uril (CB[7]) can catalyze Diels-Alder reactions for a number of substituted and unreactive N-allyl-2-furfurylamines under biomimetic conditions, without the need for protecting groups, yielding powerful synthons in previously unreported mild conditions. CB[7] rearranges the substrate in a highly reactive conformation and shields it from the aqueous environment, thereby mimicking the mode of action of a natural Diels-Alderase...
October 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29048437/photo-induced-interfacial-electron-transfer-of-zno-nanocrystals-to-control-supramolecular-assembly-in-water
#3
Anna M Cieślak, Emma-Rose Janeček, Kamil Sokołowski, Tomasz Ratajczyk, Michał K Leszczyński, Oren A Scherman, Janusz Lewiński
Herein, we show how the inherent light-induced redox properties of semiconducting nanocrystals (NCs) can be utilized for the photo-driven reversible modulation of dynamic supramolecular systems formed at their interfaces that, on their own, do not respond to light. This was achieved by the unprecedented combination of photoactive zinc oxide NCs (ZnO NCs) with a host-guest chemistry of cucurbit[8]uril (CB[8]) providing a route to the semiconductor-assisted light modulation of supramolecular assemblies (SALSA), here mediated by the photo-generation of viologen radical cations (MV˙(+)) at the NC corona and their further dimerization enhanced by CB[8] macrocycles...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/29046638/blockade-of-cannabinoid-cb1-receptors-in-the-dorsal-periaqueductal-gray-unmasks-the-antinociceptive-effect-of-local-injections-of-anandamide-in-mice
#4
Diego C Mascarenhas, Karina S Gomes, Tatiani Sorregotti, Ricardo L Nunes-de-Souza
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For instance, the stimulation of both Transient Receptor Potential Vanilloid type 1 (TRPV1) and Cannabinoid type 1 (CB1) receptors led to paradoxical effects on nociception. Here, we attempted to propose a clear and reproducible methodology to achieve the antinociceptive effect of exogenous AEA within the dorsal periaqueductal gray (dPAG) of mice exposed to the tail-flick test...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29046125/pretreatment-with-n-acetyl-cysteine-suppresses-chronic-reactive-astrogliosis-following-maternal-nanoparticle-exposure-during-gestational-period
#5
Atsuto Onoda, Ken Takeda, Masakazu Umezawa
Early pregnant employees are potentially and unintendedly exposed to industrial chemicals including nanoparticles. Developmental toxicity of nanoparticle exposure has been concerned because exposure to fine particle including carbon black nanoparticle (CB-NP) during the brain developmental stage enhances the risk of brain disorders. Maternal CB-NP exposure dose-dependently induces astrogliosis, which is an abnormal increase in the reactive astrocytes with glial fibrillary acidic protein (GFAP) and aquaporin-4 overexpression due to the destruction of nearby neurons and blood vessels...
October 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29044059/pathology-and-immunohistochemistry-of-capsular-bag-in-spontaneously-late-dislocated-capsular-bag-intraocular-lens-complex
#6
Harsha Bhattacharjee, Kasturi Bhattacharjee, Dipankar Das, Manpreet Singh, Piruthivi Sukumar, Diva Kant Misra
PURPOSE: Our study aims to evaluate the morphology, histopathology, and immunohistochemistry of the spontaneously late dislocated capsular bag-intraocular lens (CB-IOL) complex. Various etiologies and possible pathogenesis of the event are also discussed. METHODS: This was a tertiary-care setting and retrospective observational case series. The surgically explanted intact specimens of spontaneously late dislocated CB-IOL complex were studied. The demographics, duration of pseudophakia, IOL design/material, and specimen measurements were noted...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043988/effects-of-estrogen-on-learning-memory-and-expression-of-calbindin-d28k-in-hippocampus-in-vascular-dementia-rats
#7
Jing Li, Lei Zhang, Jiao-Jiao Li, - Xian-Qu, Lin Chen, Dong-Ying Li, Chun-Ying Li
Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca(2+) in hippocampus was determined by Fura-2/AM fluorescence probe and the expression of Calbindin-D28K (CB) in hippocampal CA1 was tested by immunohistochemistry. Learning-memory ability was improved in E group rats; Concentration of Ca(2+) in hippocampus was decreased in E group rats. The expression of CB was less in E group rats...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29039428/photolysis-of-polymeric-self-assembly-controlled-by-donor-acceptor-interaction
#8
Tingjuan Qian, Feiyi Chen, Yulan Chen, Yi-Xuan Wang, Wenping Hu
A photodegradable supramolecular polymer was constructed using cucurbit[8]uril (CB[8]) and an alkoxyanthracene guest. The monomeric unit was photostable because of the intramolecular donor-acceptor interaction. However, upon complexation with CB[8], the photolysis of alkoxyanthracene was enhanced, which endowed the supramolecular polymer with great photoreactivity.
October 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29036790/predictors-for-the-efficacy-of-endostar-combined-with-neoadjuvant-chemotherapy-for-stage-iiia-n2-nsclc
#9
Xiaoliang Zhao, Xiaohua Wen, Wei Wei, Yanjun Su, Jian You, Liqun Gong, Zhenfa Zhang, Meng Wang, Jianyu Xiao, Xiyin Wei, Changli Wang
BACKGROUND: Endostar (rh-endostatin) is a new recombinant human endostatin, which could inhibit cell proliferation, angiogenesis, and tumor growth. OBJECTIVE: To explore anti-angiogenesis short-term efficacy combined with neoadjuvant chemotherapy for stage IIIA (N2) non-small cell lung cancer (NSCLC), and identify the potential predictive factors. METHODS: We pathologically examined 26 patients diagnosed with stage IIIA (N2) NSCLC who received NP chemotherapy alone or combined with Endostar, respectively...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29035821/neuronal-nitric-oxide-synthase-is-involved-in-cb-trpv1-signalling-focus-on-control-of-hippocampal-hyperexcitability
#10
Fabio Carletti, Giuditta Gambino, Valerio Rizzo, Giuseppe Ferraro, Pierangelo Sardo
Cannabinoids (CB), transient receptors potential vanilloid type 1 (TRPV1) and nitric oxide (NO) were found to be interlinked in regulating some neuronal functions such as membrane excitability and synaptic transmission. TRPV1 play a fundamental role since it represents a synaptic target for CB that triggers several downstream cellular pathways. In this regard, recent evidence report that TRPV1 could influence NO production by modulating neuronal NO synthase (nNOS) activity. In the present research, we pointed to manipulate nNOS function to assess its role on TRPV1 signalling in hyperexcitability conditions elicited in the dentate gyrus of hippocampal formation...
October 3, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29035507/sequential-delivery-of-doxorubicin-and-zoledronic-acid-to-breast-cancer-cells-by-cb-7-modified-iron-oxide-nanoparticles
#11
Farah Benyettou, Marwa Alhashimi, Matthew O'Connor, Renu Pasricha, Jérémy Brandel, Hassan Trabousli, Javed Mazher, John-Carl Olsen, Ali Trabolsi
Drug-loaded magnetic nanoparticles were synthesized and used for the sequential delivery of the anti-resorptive agent zoledronic acid (Zol) and the cytotoxic drug doxorubicin (Dox) to breast cancer cells (MCF-7). Zol was attached to bare iron oxide nanoparticles (IONPs) via phosphonate coordination to form Z-NPs. The unbound imidazole of Zol was then used to complex the organic macrocycle CB[7] to obtain CZ-NPs. Dox was then complexed to the CZ-NPs to form the fully loaded particles (DCZ-NPs), which were stable in solution at 37 ºC and physiological pH (7...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29033935/cannabinoid-receptor-1-participates-in-liver-inflammation-by-promoting-m1-macrophage-polarization-via-rhoa-nf-%C3%AE%C2%BAb-p65-and-erk1-2-pathways-respectively-in-mouse-liver-fibrogenesis
#12
Lei Tian, Weiyang Li, Le Yang, Na Chang, Xiaoting Fan, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li
Macrophage M1/M2 polarization mediates tissue damage and inflammatory responses. Cannabinoid receptor (CB) 1 participated in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation. However, the knowledge of whether CB1 is involved in the polarization of BMMs remains limited. Here, we found M1 gene signatures (including CD86, MIP-1β, tumor necrosis factor, IL-6, and inducible nitric oxide synthase) and the amount of M1 macrophages (CD86(+) cells, gated by F4/80) were significantly elevated in carbon tetrachloride (CCl4)-induced mouse injured livers, while that of M2 type macrophages had little change by RT-qPCR and fluorescence-activated cell sorting (FACS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29032785/two-glutathione-transferase-isoforms-isolated-from-juvenile-cysts-of-taenia-crassiceps-identification-purification-and-characterization
#13
G Maldonado, G Nava, A Plancarte
We identified and characterized the first two glutathione transferases (GSTs) isolated from juvenile cysts of Taenia crassiceps (EC 2.5.1.18). The two glutathione transferases (TcGST1 and TcGST2) were purified in a single-step protocol using glutathione (GSH)-sepharose chromatography in combination with a GSH gradient. The specific activities of TcGST1 and TcGST2 were 26 U mg-1 and 19 U mg-1, respectively, both at 25°C and pH 6.5 with 1-chloro-2,4-dinitrobenzene (CDNB) and GSH as substrates. The K m(CDNB) and K cat(CDNB) values for TcGST1 and TcGST2 (0...
October 16, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29031095/sustainable-superior-function-of-the-synthesized-nixco1-xfe2oz-nanosphere-on-the-destruction-of-chlorinated-biphenyls-in-the-effluent
#14
Linyan Huang, Qianqian Li, Guijin Su, Minghui Zheng, Yalu Liu, Yangyang Gu, Lirong Gao, Guorui Liu, Wenbin Liu
NixCo1-xFe2Oz composite oxide nanosphere was successfully prepared, to degrade 2-monochlorobiphenly (CB-1) in continuous-flow fixed-bed microreactor at GHSV of 20000h(-1). The five cycles of temperature-dependent run experiments between 150 and 350°C showed its superior activity with a CB-1 conversion of more than 95% above 300°C over Ni0.5Co0.5Fe2Oz. Importantly, the sustainable higher reactivity could be observed over prolonged 600min reaction times after the 5th run test. The degradation products detected as biphenyl and monochlorobenzene with yield ratio of 129, account for 0...
October 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29026681/resolving-adjacent-nanophosphors-of-different-concentrations-by-excitation-based-cone-beam-x-ray-luminescence-tomography
#15
Peng Gao, Huangsheng Pu, Junyan Rong, Wenli Zhang, Tianshuai Liu, Wenlei Liu, Yuanke Zhang, Hongbing Lu
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed as a new molecular imaging modality recently. It can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays. However, the ill-posedness of the CB-XLCT inverse problem degrades the image quality and makes it difficult to resolve adjacent luminescent targets with different concentrations, which is essential in the monitoring of nanoparticle metabolism and drug delivery...
September 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29025354/cell-bound-complement-activation-products-as-lupus-biomarkers-diagnosis-monitoring-and-stratification
#16
Joseph M Ahearn, Chau-Ching Liu, Susan Manzi
Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus. Areas Covered: This review summarizes the highlights of these 14 years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine. Expert Commentary: The practice of medicine is both art and science and each physician can be considered both artist and scientist with a variable blend of the two skill sets...
October 13, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29023759/cord-blood-derived-t-cells-allow-the-generation-of-a-more-na%C3%A3-ve-tumor-reactive-cytotoxic-t-cell-phenotype
#17
Julian Kwoczek, Sebastian B Riese, Sabine Tischer, Szilvia Bak, Julia Lahrberg, Mathias Oelke, Holger Maul, Rainer Blasczyk, Martin Sauer, Britta Eiz-Vesper
BACKGROUND: Transplantation of hematopoietic stem cells (HSCs) from peripheral blood (PB) or cord blood (CB) is well established. HSCs from CB are associated with a lower risk of graft-versus-host disease (GVHD), but antigen-independent expanded CB- and PB-derived T cells can induce GVHD in allo-HSC recipients. CB-derived cells might be more suitable for adoptive immunotherapy as they have unique T-cell characteristics. Here, we describe functional differences between CB and PB T cells stimulated with different cytokine combinations involved in central T-cell activation...
October 11, 2017: Transfusion
https://www.readbyqxmd.com/read/29021138/glutamine-addiction-in-kidney-cancer-suppresses-oxidative-stress-and-can-be-exploited-for-real-time-imaging
#18
Omran Abu Aboud, Samy Habib, Josephine F Trott, Benjamin Stewart, Sitai Liang, Abhijit J Chaudhari, Julie L Sutcliffe, Robert H Weiss
Many cancers appear to activate intrinsic antioxidant systems as a means to counteract oxidative stress. Some cancers, such as clear cell renal cell carcinoma (ccRCC), require exogenous glutamine for growth and exhibit reprogrammed glutamine metabolism, at least in part due to the glutathione pathway, an efficient cellular buffering system that counteracts reactive oxygen species (ROS) and other oxidants. We show here that ccRCC xenograft tumors under the renal capsule exhibit enhanced oxidative stress compared to adjacent normal tissue and the contralateral kidney...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29020057/high-dose-teriparatide-rpth1-34-therapy-increases-callus-volume-and-enhances-radiographic-healing-at-8-weeks-in-a-massive-canine-femoral-allograft-model
#19
Kohei Nishitani, Zachary Mietus, Christopher A Beck, Hiromu Ito, Shuichi Matsuda, Hani A Awad, Nicole Ehrhart, Edward M Schwarz
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-unions, we evaluated rPTH1-34 safety and efficacy in a clinically relevant canine femoral allograft model. Adult female mongrel hounds (n = 20) received a 5cm mid-diaphyseal osteotomy reconstructed with a plated allograft, and were randomized to: 1) Placebo (n = 5; daily saline), 2) Continuous rPTH1-34 (n = 7; 5 μg/kg/day s...
2017: PloS One
https://www.readbyqxmd.com/read/29019707/glutaminolysis-promotes-collagen-translation-and-stability-via-%C3%AE-ketoglutarate-mediated-mtor-activation-and-proline-hydroxylation
#20
Jing Ge, Huachun Cui, Na Xie, Sami Banerjee, Sijia Guo, Shubham Dubey, Stephen Barnes, Gang Liu
Glutaminolysis is the metabolic process of glutamine, of which aberration has been implicated in several pathogeneses. While we and others recently found a diversity of metabolic dysregulations in organ fibrosis, it is unknown if glutaminolysis regulates the pro-fibrotic activities of myofibroblasts, the primary effector in this pathology. In this study, we found that lung myofibroblasts demonstrated significantly augmented glutaminolysis that was mediated by elevated Glutaminase 1 (Gls1). Inhibition of glutaminolysis by specific Gls1 inhibitors CB-839 and BPTES as well as Gls1 siRNA blunted the expression of collagens, but not that of Fibronectin, Elastin or myofibroblastic marker smooth muscle actin α (SMA-α)...
October 11, 2017: American Journal of Respiratory Cell and Molecular Biology
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