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https://www.readbyqxmd.com/read/29454037/melatonin-attenuates-%C3%AE-9-tetrahydrocannabinol-induced-reduction-in-rat-sperm-motility-and-kinematics-in-vitro
#1
Isiaka Abdullateef Alagbonsi, Luqman Aribidesi Olayaki
The use of Cannabis sativa (CS) has been widely demonstrated to have detrimental effect on male reproductive functions. Despite the well-known existence of endocannabinoid and melatonergic systems in semen, the physiological significance of their interaction is not understood. We recently showed that melatonin exacerbates the CS-induced gonadotoxicity in-vivo. To overcome the limitations associated with our in-vivo studies and further understand the role of cannabinoid-melatonin relationship in sperm functions, this study investigated the in-vitro effect of tetrahydrocannabinol (THC) and/or melatonin on motility and kinematics of capacitating rat sperms...
February 14, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29454025/early-alteration-of-distribution-and-activity-of-hippocampal-type-1-cannabinoid-receptor-in-alzheimer-s-disease-like-mice-overexpressing-the-human-mutant-amyloid-precursor-protein
#2
Mauro Maccarrone, Antonio Totaro, Alessandro Leuti, Giacomo Giacovazzo, Lucia Scipioni, Dalila Mango, Roberto Coccurello, Robert Nisticò, Sergio Oddi
Besides its involvement in Alzheimer's disease (AD) as precursor of the neurotoxic amyloid peptides, the pathophysiological impact of brain accumulation of amyloid precursor protein (APP) is not yet well understood. Recent studies reported that APP interacts with other membrane proteins, including G protein coupled receptors, affecting their biological functions. Here, we focused on the study of the potential impact of human mutant APP on expression, distribution and activity of type-1 cannabinoid (CB 1 ) receptor in the hippocampus of Tg2576 mice, an AD-like mice model...
February 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29452395/mini-extracorporeal-circulation-technology-conventional-bypass-and-prime-displacement-in-isolated-coronary-and-aortic-valve-surgery-a-propensity-matched-in-hospital-and-survival-analysis
#3
Priyadharshanan Ariyaratnam, Lindsay A Mclean, Alexander Cale, Mubarak A Chaudhry, Ajith Vijayan, Neil Richards, Martin A Jarvis, Yama Haqzad, Dumbor Ngaage, Michael E Cowen, Mahmoud Loubani
OBJECTIVES: Conventional cardiopulmonary bypass is the most commonly used means of artificial circulation in cardiac surgery. However, it suffers from the effects of haemodilution and activation of inflammatory/coagulation cascades. Prime displacement (PD) can offset haemodilution and Mini-Extracorporeal Technology (MIECT) can offset both. So far, no study has compared all of these modalities together; hence, we compared the outcomes of these 3 modalities at our institution. METHODS: This was a retrospective analysis of our cardiac surgical database...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29452272/ph-sensitive-doxorubicin-conjugated-prodrug-micelles-with-charge-conversion-for-cancer-therapy
#4
Boxuan Ma, Weihua Zhuang, Yanan Wang, Rifang Luo, Yunbing Wang
Intelligent drug delivery systems with prolonged circulation time, reduced drug leakage in blood, target site-triggered drug release and endosomal escape are attractive and ideal for malignant tumor therapy. Herein, doxorubicin (DOX)-conjugated smart polymeric micelles based on 4-carboxy benzaldehyde-grafted poly (L-lysine)-block-poly (methacryloyloxyethyl phosphorylcholine) (PLL(CB/DOX)-b-PMPC) copolymer are prepared. DOX and electronegative 4-carboxy benzaldehyde are conjugated to the PLL block via an imine linkage and as a result, the drug loaded micelles exhibited the pH-triggered charge-conversion property and accelerated drug release at tumor pH...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29450258/the-cannabinoids-%C3%AE-8-thc-cbd-and-hu-308-act-via-distinct-receptors-to-reduce-corneal-pain-and-inflammation
#5
Dinesh Thapa, Elizabeth A Cairns, Anna-Maria Szczesniak, James T Toguri, Meggie D Caldwell, Melanie E M Kelly
Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB 1 R) and cannabinoid 2 (CB 2 R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia. Methods: Corneal hyperalgesia (increased pain response) was generated using chemical cauterization of the corneal epithelium in wild-type (WT) and CB 2 R knockout (CB 2 R -/- ) mice...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29445985/acute-pericarditis-following-second-generation-cryoballoon-ablation-for-atrial-fibrillation
#6
Giacomo Mugnai, Carlo de Asmundis, Saverio Iacopino, Erwin Ströker, Massimo Longobardi, Maria Claudia Negro, Valentina De Regibus, Hugo Enrique Coutino-Moreno, Ken Takarada, Rajin Choudhury, Juan Pablo Abugattas de Torres, Cesare Storti, Pedro Brugada, Gian-Battista Chierchia
PURPOSE: Acute pericarditis is a minor complication following atrial fibrillation (AF) ablation procedures. The aim of the study was to evaluate the incidence and clinical aspects of pericarditis following cryoballoon (CB) ablation of AF investigating a possible association with procedural characteristics and a possible relationship with post-ablation recurrences. METHODS: Four hundred fifty consecutive patients (male 73%, age 59.9 ± 11.2 years) with drug-resistant paroxysmal AF who underwent CB ablation as index procedure were enrolled...
February 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29445178/the-effect-of-clostridium-butyricum-on-symptoms-and-fecal-microbiota-in-diarrhea-dominant-irritable-bowel-syndrome-a-randomized-double-blind-placebo-controlled-trial
#7
Yi-Yuan Sun, Ming Li, Yue-Yue Li, Li-Xiang Li, Wen-Zhe Zhai, Peng Wang, Xiao-Xiao Yang, Xiang Gu, Li-Jin Song, Zhen Li, Xiu-Li Zuo, Yan-Qing Li
Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444409/sequence-specific-self-assembly-of-positive-and-negative-monomers-with-cucurbit-8-uril-linkers
#8
Mersad Raeisi, Kondalarao Kotturi, Ian Del Valle, Jan Schulz, Paulina Dornblut, Eric Masson
The self-assembly into dynamic oligomers of Cucurbit[8]uril (CB[8]), a positive ditopic Ir(III) bis-terpyridine complex, and a negative ditopic Fe(II) bis-terpyridine complex flanked by four butyrate side chains was assessed to answer a seemingly straightforward question: does CB[8] adopt a social self-sorting pattern by encapsulating both positive and negative units into a hetero-ternary complex? We showed that this is indeed the case, with CB[8] linking a positive Ir unit to a neighboring negative Fe unit whenever possible...
February 14, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29442838/manganese-doped-ceo%C3%A2-nanocubes-for-catalytic-combustion-of-chlorobenzene-an-experimental-and-density-functional-theory-study
#9
Pei Zhao, Zhansheng Lu, Shantang Liu
Manganese oxide (MnOx) supported on CeO2 nanocubes (MnOx/CeO2) were synthesized and tested for the catalytic combustion of chlorobenzene (CB), which was taken as a model compound of chlorinated volatile organic compounds (CVOCs). The catalytic activity tests demonstrated that MnOx/CeO2 nanocube catalysts exhibited a catalytic activity significantly better than that of bare CeO2 nanocubes, indicating MnOx plays a significant role for CB oxidation. To illustrate the effect of MnOx on the CeO2 nanocubes, experimental and theoretical methods such as density functional theory (DFT) calculations were carried out...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441900/role-of-the-endocannabinoid-system-in-the-formation-and-development-of-depression
#10
Dan Zhou, Yue Li, Tian Tian, Wei Quan, Lei Wang, Qing Shao, Lian-Qiang Fu, Xiao-Hong Zhang, Xiao-Ye Wang, Hui Zhang, Yan-Min Ma
Two types of cannabinoid (CB) receptors have been described in the human body: CB1 and CB2 receptors. CB1 receptor distribution may be related to the cannabinoid functions of memory and cognition regulation as well as motor control. In addition, the endocannabinoid system (ECS) related to CB1 receptors may be involved in human emotion regulation, especially depression occurrence. Indeed, CB1 receptors are all distributed in depression associated neuroanatomical structures and neural circuits. Both animal experiments and clinical studies have demonstrated that impairment of the ECS pathway is present in depression models and patients, and application of both CB1 receptor agonists and anandamide (cannabinoid-like substance) degradation inhibitors produce similar biochemical and behavioral effects as antidepressants...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441824/green-synthesis-of-silver-nanoparticles-combined-to-calcium-glycerophosphate-antimicrobial-and-antibiofilm-activities
#11
José As Souza, Debora B Barbosa, Andresa A Berretta, Jackeline G do Amaral, Luiz F Gorup, Francisco N de Souza Neto, Renan A Fernandes, Gabriela L Fernandes, Emerson R Camargo, Alessandra M Agostinho, Alberto Cb Delbem
AIM: To synthesize, characterize and evaluate the antimicrobial and antibiofilm activities of novel nanocomposites containing silver nanoparticles (AgNPs) associated or not to β-calcium glycerophosphate. MATERIALS & METHODS: These nanocomposites were produced through a 'green' route using extracts of different parts of pomegranate. Antimicrobial and antibiofilm properties against Candida albicans and Streptococcus mutans were determined by the minimum bactericidal/fungicidal concentration and biofilm density after treatments...
February 14, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29437461/simultaneous-conduction-and-valence-band-quantization-in-ultrashallow-high-density-doping-profiles-in-semiconductors
#12
F Mazzola, J W Wells, A C Pakpour-Tabrizi, R B Jackman, B Thiagarajan, Ph Hofmann, J A Miwa
We demonstrate simultaneous quantization of conduction band (CB) and valence band (VB) states in silicon using ultrashallow, high-density, phosphorus doping profiles (so-called Si:P δ layers). We show that, in addition to the well-known quantization of CB states within the dopant plane, the confinement of VB-derived states between the subsurface P dopant layer and the Si surface gives rise to a simultaneous quantization of VB states in this narrow region. We also show that the VB quantization can be explained using a simple particle-in-a-box model, and that the number and energy separation of the quantized VB states depend on the depth of the P dopant layer beneath the Si surface...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29436545/compartmentalized-supramolecular-hydrogels-based-on-viral-nanocages-towards-sophisticated-cargo-administration
#13
Liulin Yang, Aijie Liu, Mark V de Ruiter, Catharina A Hommersom, Nathalie Katsonis, Pascal Jonkheijm, Jeroen J L M Cornelissen
Introduction of compartments with defined spaces inside a hydrogel network brings unique features, such as cargo quantification, stabilization and diminishment of burst release, which are all desired for biomedical applications. As a proof of concept, guest-modified cowpea chlorotic mottle virus (CCMV) particles and complementary guest-modified hydroxylpropyl cellulose (HPC) were non-covalently cross-linked through the formation of ternary host-guest complexes with cucurbit[8]uril (CB[8]). Furthermore, CCMV based virus-like particles (VLPs) loaded with tetrasulfonated zinc phthalocyanine (ZnPc) were prepared, with a loading efficiency up to 99%, which are subsequently successfully integrated inside the supramolecular hydrogel network...
February 13, 2018: Nanoscale
https://www.readbyqxmd.com/read/29431843/enhancement-of-metal-metal-interactions-inside-a-large-cavity-synthetic-host-in-water
#14
Shengjian Kuang, Zhixiong Hu, Hao Zhang, Xiongzhi Zhang, Feng Liang, Zhiyong Zhao, Simin Liu
The encapsulation of a series of metal-terpyridyl complexes in cucurbit[10]uril (CB[10]) in water is described. A strong enhancement of metal-metal and π-π interactions is observed due to double confinement in the large cavity. Furthermore, a linear supramolecular polymer featuring host-enhanced metallophilic interactions in water can be prepared.
February 12, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29429522/neurochemical-characteristics-of-calbindin-like-immunoreactive-coeliac-cranial-mesenteric-ganglion-complex-ccmg-neurons-supplying-the-pre-pyloric-region-of-the-porcine-stomach
#15
Katarzyna Palus, Michał Bulc, Marta Czajkowska, Bartosz Miciński, Jarosław Całka
The present study was designed to determine the distribution, morphology and co-localization of calbindin-D28k (CB) with other neuroactive substances in the coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the prepyloric region of the porcine stomach. In all animals, a median laparotomy was performed and the fluorescent retrograde neuronal tracer Fast Blue was injected into the wall of the stomach prepyloric area. On the 28th day, all animals were euthanized and the CCMG complexes were then collected and processed for double-labelling immunofluorescence for CB and tyrosine hydroxylase (TH), galanin (GAL), somatostatin (SOM), leu 5-enkephalin (LENK), vasoactive intestinal peptide (VIP), substance P (SP) and cocaine- and amphetamine-regulated transcript peptide (CART), Immunohistochemistry revealed that 8...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29428866/prognostic-value-of-circulating-biomarker-score-in-advanced-stage-head-and-neck-squamous-cell-carcinoma
#16
Marn Joon Park, Jong-Lyel Roh, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Circulating biomarker (CB) is a convenient, emerging predictive tool for treatment response and outcomes in human cancers. Therefore, we examined the prognostic value of pre-treatment and early post-treatment CBs and their summated scores in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This study prospectively included 310 consecutive patients who underwent definitive treatment for previously untreated advanced-stage HNSCC between 2010 and 2015...
February 8, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29428092/detection-of-specific-bacterial-agents-by-quantitative-pcr-assays-in-the-bronchoalveolar-lavage-fluid-of-dogs-with-eosinophilic-bronchopneumopathy-vs-dogs-with-chronic-bronchitis-and-healthy-dogs
#17
A M Canonne, I Peters, E Roels, L Desquilbet, C Clercx
In humans, Mycoplasma pneumoniae and Bordetella pertussis infections are suggested to trigger or exacerbate asthma. Whether Mycoplasma or Bordetella are associated with chronic inflammatory bronchial diseases in dogs has not been investigated. The aim of this study was to assess detection rates of Mycoplasma canis (M. canis), M. cynos and Bordetella bronchiseptica (Bb), in dogs with eosinophilic bronchopneumopathy (EBP) and chronic bronchitis (CB), compared with healthy dogs. Specific quantitative PCR (qPCR) analysis for M...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29426136/first-report-of-bioaccumulation-and-bioconcentration-of-aliphatic-hydrocarbons-ahs-and-persistent-organic-pollutants-pahs-pcbs-and-pcns-and-their-effects-on-alcyonacea-and-scleractinian-corals-and-their-endosymbiotic-algae-from-the-persian-gulf-iran-inter-and
#18
Ali Ranjbar Jafarabadi, Alireza Riyahi Bakhtiari, Mansour Aliabadian, Hédouin Laetitia, Amirhossein Shadmehri Toosi, Chee Kong Yap
The coral reefs of the Persian Gulf are the most diverse systems of life in the marine environment of the Middle East. Unfortunately, they are highly threatened by local and global stressors, particularly oil pollutants. This is the first quantitative and qualitative study aimed at assessing the concentration and sources of n-alkanes and POPs (PAHs, PCBs and PCNs) in coral tissues, symbiotic algae (zooxanthellae), reef sediments and seawaters in coral reefs of Lark and Kharg in the Persian Gulf, Iran. This work was conducted on eight species of six genera and three families of hard corals and one family of soft coral...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29425847/-all-in-one-in%C3%A2-vitro-selection-of-collagen-binding-vascular-endothelial-growth-factor
#19
Shin-Hye Park, Takanori Uzawa, Fumiyuki Hattori, Shuichi Ogino, Naoki Morimoto, Satoshi Tsuneda, Yoshihiro Ito
To enhance the therapeutic effect of growth factors, a powerful strategy is to direct their localization to damaged sites. To treat skin wounds and myocardial infarction, we selected vascular endothelial growth factor (VEGF) carrying binding affinity to collagen. A simple conjugation of a reported collagen-binding sequence and VEGF did not increase the collagen-binding affinity, indicating that the molecular interaction between the two proteins abolished collagen binding activity. Here, we present a new molecular evolution strategy, "all-in-one" in vitro selection, in which a collagen-binding VEGF (CB-VEGF) was directly identified from a random library consisting of random and VEGF sequences...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29423637/complementary-expression-of-calcium-binding-proteins-delineates-the-functional-organization-of-the-locomotor-network
#20
Eva M Berg, Maria Bertuzzi, Konstantinos Ampatzis
Neuronal networks in the spinal cord generate and execute all locomotor-related movements by transforming descending signals from supraspinal areas into appropriate rhythmic activity patterns. In these spinal networks, neurons that arise from the same progenitor domain share similar distribution patterns, neurotransmitter phenotypes, morphological and electrophysiological features. However, subgroups of them participate in different functionally distinct microcircuits to produce locomotion at different speeds and of different modalities...
February 8, 2018: Brain Structure & Function
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