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Bernd Hoppe, Jaap W Groothoff, Sally-Anne Hulton, Pierre Cochat, Patrick Niaudet, Markus J Kemper, George DeschĂȘnes, Robert Unwin, Dawn Milliner
BACKGROUND: Primary hyperoxaluria (PH) is a rare genetic disease, in which high urinary oxalate (Uox) cause recurrent kidney stones and/or progressive nephrocalcinosis, often followed by early end-stage renal disease, as well as extremely high plasma oxalate, systemic oxalosis and premature death. Oxalobacter formigenes, an anaerobic oxalate degrading bacterium, naturally colonizes the colon of most humans. Orally administered O. formigenes (Oxabact) was found to significantly reduce urine and plasma oxalate...
November 2011: Nephrology, Dialysis, Transplantation
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