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https://www.readbyqxmd.com/read/29133405/parallel-magnetic-field-suppresses-dissipation-in-superconducting-nanostrips
#1
Yong-Lei Wang, Andreas Glatz, Gregory J Kimmel, Igor S Aranson, Laxman R Thoutam, Zhi-Li Xiao, Golibjon R Berdiyorov, François M Peeters, George W Crabtree, Wai-Kwong Kwok
The motion of Abrikosov vortices in type-II superconductors results in a finite resistance in the presence of an applied electric current. Elimination or reduction of the resistance via immobilization of vortices is the "holy grail" of superconductivity research. Common wisdom dictates that an increase in the magnetic field escalates the loss of energy since the number of vortices increases. Here we show that this is no longer true if the magnetic field and the current are applied parallel to each other. Our experimental studies on the resistive behavior of a superconducting Mo0...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29126887/combined-administration-of-resolvin-e1-and-lipoxin-a4-resolves-inflammation-in-a-murine-model-of-alzheimer-s-disease
#2
Alpdogan Kantarci, Nurgul Aytan, Iro Palaska, Danielle Stephens, Leah Crabtree, Claudia Benincasa, Bruce G Jenkins, Isabel Carreras, Alpaslan Dedeoglu
Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease (AD). In this study, we found that the levels of specialized pro-resolving lipid mediators (SPMs) in the hippocampus of 5xFAD mice are significantly lower than in non-transgenic littermates. We, therefore, tested the hypothesis that treatment with resolvin E1 (RvE1) and lipoxin A4 (LXA4) alone or in combination will reverse the neuroinflammatory process and decrease Aβ pathology. 5xFAD mice were treated intraperitoneally starting at 1month of age with RvE1 or LXA4 alone or in combination at a dose of 1...
November 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29116485/prevalence-risk-factors-and-response-to-treatment-for-hypersomnia-of-central-origin-in-survivors-of-childhood-brain-tumors
#3
Raja B Khan, Thomas E Merchant, Zsila S Sadighi, Mercedes S Bello, Zhaohua Lu, April Sykes, Merrill S Wise, Valerie M Crabtree, Jennifer Zabrowski, Andrea Simmons, Mary E Clark, Belinda N Mandrell
Daytime sleepiness is recognized in childhood brain tumor survivors. Our objective was to determine prevalence, risk factors for PSG/MLST proven hypersomnia/narcolepsy, and response to stimulants in childhood brain tumor survivors. Standard PSG/MSLT criteria were used to diagnose hypersomnia/narcolepsy. Medical records of brain tumor survivors having undergone a PSG/MSLT were reviewed for the diagnostic code of hypersomnia/narcolepsy. Survivors with hypersomnia/narcolepsy were matched with 2-3 survivors without reported hypersomnia/narcolepsy by age at tumor diagnosis, gender, and time from tumor diagnosis...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29116420/assessing-autism-in-adults-an-evaluation-of-the-developmental-dimensional-and-diagnostic-interview-adult-version-3di-adult
#4
William Mandy, Kiri Clarke, Michele McKenner, Andre Strydom, Jason Crabtree, Meng-Chuan Lai, Carrie Allison, Simon Baron-Cohen, David Skuse
We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (αs ≥ 0...
November 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29092451/primordial-oscillations-in-life-direct-observation-of-glycolytic-oscillations-in-individual-hela-cervical-cancer-cells
#5
Takashi Amemiya, Kenichi Shibata, Yoshihiro Itoh, Kiminori Itoh, Masatoshi Watanabe, Tomohiko Yamaguchi
We report the first direct observation of glycolytic oscillations in HeLa cervical cancer cells, which we regard as primordial oscillations preserved in living cells. HeLa cells starved of glucose or both glucose and serum exhibited glycolytic oscillations in nicotinamide adenine dinucleotide (NADH), exhibiting asynchronous intercellular behaviors. Also found were spatially homogeneous and inhomogeneous intracellular NADH oscillations in the individual cells. Our results demonstrate that starved HeLa cells may be induced to exhibit glycolytic oscillations by either high-uptake of glucose or the enhancement of a glycolytic pathway (Crabtree effect or the Warburg effect), or both...
October 2017: Chaos
https://www.readbyqxmd.com/read/29069391/dimensions-and-intensity-of-inter-professional-teamwork-in-primary-care-evidence-from-five-international-jurisdictions
#6
Jean-Frederic Levesque, Mark F Harris, Cathie Scott, Benjamin Crabtree, William Miller, Lisa M Halma, William E Hogg, Jan-Willem Weenink, Jenny R Advocat, Jane Gunn, Grant Russell
Background: Inter-professional teamwork in primary care settings offers potential benefits for responding to the increasing complexity of patients' needs. While it is a central element in many reforms to primary care delivery, implementing inter-professional teamwork has proven to be more challenging than anticipated. Objective: The objective of this study was to better understand the dimensions and intensity of teamwork and the developmental process involved in creating fully integrated teams...
October 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29069376/contextual-levers-for-team-based-primary-care-lessons-from-reform-interventions-in-five-jurisdictions-in-three-countries
#7
Grant M Russell, William L Miller, Jane M Gunn, Jean-Frederic Levesque, Mark F Harris, William E Hogg, Cathie M Scott, Jenny R Advocat, Lisa Halma, Sabrina M Chase, Benjamin F Crabtree
Background: Most Western nations have sought primary care (PC) reform due to the rising costs of health care and the need to manage long-term health conditions. A common reform-the introduction of inter-professional teams into traditional PC settings-has been difficult to implement despite financial investment and enthusiasm. Objective: To synthesize findings across five jurisdictions in three countries to identify common contextual factors influencing the successful implementation of teamwork within PC practices...
October 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29069335/uncovering-the-wisdom-hidden-between-the-lines-the-collaborative-reflexive-deliberative-approach
#8
Benjamin F Crabtree, William L Miller, Jane M Gunn, William E Hogg, Cathie M Scott, Jean-Frederic Levesque, Mark F Harris, Sabrina M Chase, Jenny R Advocat, Lisa M Halma, Grant M Russell
Background: Meta-analysis and meta-synthesis have been developed to synthesize results across published studies; however, they are still largely grounded in what is already published, missing the tacit 'between the lines' knowledge generated during many research projects that are not intrinsic to the main objectives of studies. Objective: To develop a novel approach to expand and deepen meta-syntheses using researchers' experience, tacit knowledge and relevant unpublished materials...
October 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29062047/protein-peptide-association-kinetics-beyond-the-seconds-timescale-from-atomistic-simulations
#9
Fabian Paul, Christoph Wehmeyer, Esam T Abualrous, Hao Wu, Michael D Crabtree, Johannes Schöneberg, Jane Clarke, Christian Freund, Thomas R Weikl, Frank Noé
Understanding and control of structures and rates involved in protein ligand binding are essential for drug design. Unfortunately, atomistic molecular dynamics (MD) simulations cannot directly sample the excessively long residence and rearrangement times of tightly binding complexes. Here we exploit the recently developed multi-ensemble Markov model framework to compute full protein-peptide kinetics of the oncoprotein fragment (25-109)Mdm2 and the nano-molar inhibitor peptide PMI. Using this system, we report, for the first time, direct estimates of kinetics beyond the seconds timescale using simulations of an all-atom MD model, with high accuracy and precision...
October 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29056113/evaluation-of-the-thermo-scientific-rapidfinder%C3%A2-salmonella-species-typhimurium-and-enteritidis-multiplex-pcr-kit
#10
Emma Scopes, Jessica Screen, Katharine Evans, David Crabtree, Annette Hughes, Mikko Kaupinen, Jonathan Flannery, Patrick Bird, M Joseph Benzinger, James Agin, David Goins
The Thermo Scientific RapidFinder™ Salmonella Species, Typhimurium, and Enteritidis Multiplex PCR Kit (candidate method) is a real-time PCR assay for the detection and differentiation of Salmonella spp., and the serovars S. Typhimurium, and S. Enteritidis from poultry, pork, and environmental samples. The method was validated in comparison to the U.S. Department of Agriculture Food Safety and Inspection Service and the U.S. Food and Drug Administration reference methods. Thermo Fisher Scientific (Basingstoke, United Kingdom) tested all matrixes...
October 23, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29054210/the-society-of-thoracic-surgeons-general-thoracic-surgery-database-2017-update-on-research
#11
REVIEW
Henning A Gaissert, Felix G Fernandez, Traves Crabtree, William R Burfeind, Mark S Allen, Mark I Block, Paul H Schipper, Jeffrey P Jacobs, Robert H Habib, David M Shahian
The outcomes research efforts based on The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database include two established research programs with dedicated task forces and with data analyses conducted at the STS data analytic center: (1) The STS-sponsored research by the Access and Publications program, and (2) grant and institutionally funded research by the Longitudinal Follow-Up and Linked Registries Task Force. Also, the STS recently introduced the research program enabling investigative teams to apply for access to deidentified patient-level General Thoracic Surgery Database data sets and conduct related analyses at their own institution...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29022944/erratum-strains-functions-and-dynamics-in-the-expanded-human-microbiome-project
#12
Jason Lloyd-Price, Anup Mahurkar, Gholamali Rahnavard, Jonathan Crabtree, Joshua Orvis, A Brantley Hall, Arthur Brady, Heather H Creasy, Carrie McCracken, Michelle G Giglio, Daniel McDonald, Eric A Franzosa, Rob Knight, Owen White, Curtis Huttenhower
This corrects the article DOI: 10.1038/nature23889.
October 12, 2017: Nature
https://www.readbyqxmd.com/read/28988216/efficacy-and-treatment-costs-of-zoledronate-versus-pamidronate-in-paediatric-osteoporosis
#13
Vrinda Saraff, Jaskiran Sahota, Nicola Crabtree, Sophia Sakka, Nicholas J Shaw, Wolfgang Högler
Intravenous pamidronate has been used in the treatment of osteogenesis imperfecta (OI) in children for over 20 years. The more potent zoledronate is an attractive alternative as it is administered less frequently. This study compares the clinical efficacy of intravenous pamidronate (1.5 mg/kg/day over 2 days, every 3 months) versus zoledronate (0.05 mg/kg/dose every 6 months) in 40 children (20 per group) with mild to moderate OI and the treatment costs of the two drugs in a tertiary centre for children with osteoporosis...
October 7, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28973067/cancer-survivorship-care-in-advanced-primary-care-practices-a-qualitative-study-of-challenges-and-opportunities
#14
Ellen B Rubinstein, William L Miller, Shawna V Hudson, Jenna Howard, Denalee O'Malley, Jennifer Tsui, Heather Sophia Lee, Alicja Bator, Benjamin F Crabtree
Importance: Despite a decade of effort by national stakeholders to bring cancer survivorship to the forefront of primary care, there is little evidence to suggest that primary care has begun to integrate comprehensive services to manage the care of long-term cancer survivors. Objective: To explain why primary care has not begun to integrate comprehensive cancer survivorship services. Design, Setting, and Participants: Comparative case study of 12 advanced primary care practices in the United States recruited from March 2015 to February 2017...
September 25, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28967885/assessment-of-variation-in-microbial-community-amplicon-sequencing-by-the-microbiome-quality-control-mbqc-project-consortium
#15
Rashmi Sinha, Galeb Abu-Ali, Emily Vogtmann, Anthony A Fodor, Boyu Ren, Amnon Amir, Emma Schwager, Jonathan Crabtree, Siyuan Ma, Christian C Abnet, Rob Knight, Owen White, Curtis Huttenhower
In order for human microbiome studies to translate into actionable outcomes for health, meta-analysis of reproducible data from population-scale cohorts is needed. Achieving sufficient reproducibility in microbiome research has proven challenging. We report a baseline investigation of variability in taxonomic profiling for the Microbiome Quality Control (MBQC) project baseline study (MBQC-base). Blinded specimen sets from human stool, chemostats, and artificial microbial communities were sequenced by 15 laboratories and analyzed using nine bioinformatics protocols...
November 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28961804/association-of-household-food-and-drink-sharing-practices-with-human-herpesvirus-8-seroconversion-in-a-cohort-of-zambian-children
#16
Kay L Crabtree, Janet M Wojcicki, Veenu Minhas, Chipepo Kankasa, Charles Mitchell, Charles Wood
Background: Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods: We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results: We report an incidence of 30...
October 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28956351/the-response-of-human-bacteria-to-static-magnetic-field-and-radiofrequency-electromagnetic-field
#17
David P E Crabtree, Brandon J Herrera, Sanghoon Kang
Cell phones and electronic appliances and devices are inseparable from most people in modern society and the electromagnetic field (EMF) from the devices is a potential health threat. Although the direct health effect of a cell phone and its radiofrequency (RF) EMF to human is still elusive, the effect to unicellular organisms is rather apparent. Human microbiota, including skin microbiota, has been linked to a very significant role in the health of a host human body. It is important to understand the response of human skin microbiota to the RF-EMF from cell phones and personal electronic devices, since this may be one of the potential mechanisms of a human health threat brought about by the disruption of the intimate and balanced host-microbiota relationship...
October 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28953883/strains-functions-and-dynamics-in-the-expanded-human-microbiome-project
#18
Jason Lloyd-Price, Anup Mahurkar, Gholamali Rahnavard, Jonathan Crabtree, Joshua Orvis, A Brantley Hall, Arthur Brady, Heather H Creasy, Carrie McCracken, Michelle G Giglio, Daniel McDonald, Eric A Franzosa, Rob Knight, Owen White, Curtis Huttenhower
The characterization of baseline microbial and functional diversity in the human microbiome has enabled studies of microbiome-related disease, diversity, biogeography, and molecular function. The National Institutes of Health Human Microbiome Project has provided one of the broadest such characterizations so far. Here we introduce a second wave of data from the study, comprising 1,631 new metagenomes (2,355 total) targeting diverse body sites with multiple time points in 265 individuals. We applied updated profiling and assembly methods to provide new characterizations of microbiome personalization...
October 5, 2017: Nature
https://www.readbyqxmd.com/read/28950783/safety-and-effectiveness-of-the-phoenix-atherectomy-system-in-lower-extremity-arteries-early-and-midterm-outcomes-from-the-prospective-multicenter-ease-study
#19
Thomas Davis, Venkatesh Ramaiah, Khusrow Niazi, Hans Martin Gissler, Tami Crabtree
Objectives To evaluate the novel Phoenix Atherectomy System as percutaneous treatment of de novo and restenotic infrainguinal arterial lesions. Methods This prospective, multicenter, nonrandomized investigational device exemption trial was conducted across 16 US and German centers between August 2010 and April 2013. Intention-to-treat enrollment was 128 patients (mean age: 71.8 years, 59% male) with 149 lesions (mean length: 34 mm, mean diameter stenosis: 89.5%), and the primary analysis per-protocol population consisted of 105 patients with 123 lesions...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28938474/response-to-letter-to-the-editor-the-effect-of-whole-body-vibration-training-on-bone-and-muscle-function-in-children-with-osteogenesis-imperfecta
#20
Wolfgang Högler, Nick Bishop, Peter Nightingale, Nick Shaw, Raja Padidela, Nicola Crabtree
No abstract text is available yet for this article.
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
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