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https://www.readbyqxmd.com/read/28093891/multifaceted-effects-of-antimetabolite-and-anticancer-drug-2-deoxyglucose-on-eukaryotic-cancer-models-budding-and-fission-yeast
#1
REVIEW
Akshay Vishwanatha, Cletus Joseph Michael D'Souza
Glycolytic inhibitors are of interest therapeutically as they are effective against cancers that display increased glycolytic rate and mitochondrial defects. 2-Deoxyglucose (2-DG) is one such glycolytic inhibitor and was identified to be a competitive inhibitor of glucose. Studies from past few decades have shown that the mechanism of action of 2-DG is complex involving several metabolic and signaling pathways. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are two important models for studying metabolism, cell cycle and cell signaling...
January 17, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28090113/examining-the-foundation-of-aacp-report-of-the-2015-16-argus-commission
#2
Rodney A Carter, J Lyle Bootman, Patricia A Chase, Brian L Crabtree, Peggy Piascik, Lucinda L Maine
No abstract text is available yet for this article.
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28064490/evolution-and-prospects-of-the-asymmetric-hydrogenation-of-unfunctionalized-olefins
#3
Cristiana Margarita, Pher G Andersson
The catalytic enantioselective hydrogenation of prochiral olefins is a key reaction in asymmetric synthesis. Its relevance applies to both industry and academia as an inherently direct and sustainable strategy to induce chirality. Here we briefly recount the early breakthroughs concerning the asymmetric hydrogenation of largely unfunctionalized olefins, from the first reports to the advent of chiral Crabtree-like catalysts. The mechanism and its implications on the enantioselectivity are shortly discussed. The main focus of this Perspective lies on the more recent advances in the field, such as the latest developed classes of ligands and the opportunity to employ more Earth-abundant metals...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28057356/cell-wall-synthesis-and-central-carbohydrate-metabolism-are-interconnected-by-the-snf1-mig1-pathway-in-kluyveromyces-lactis
#4
Dorthe Rippert, Katja Backhaus, Rosaura Rodicio, Jürgen J Heinisch
The trimeric AMP-activated kinase complex (AMPK) is conserved from yeast to humans and is best known for its role in balancing energy metabolism. Additional functions, including the regulation of cell wall biosynthesis, have been proposed for the SNF1 complex, the baker's yeast homolog of AMPK. We here demonstrate that this function is conserved in the Crabtree-negative milk yeast Kluyveromyces lactis. Deletion mutants in the genes encoding the subunits of the trimeric complex (Klsnf1, Klgal83, Klsnf4) displayed increased sensitivities towards cell wall stress agents and a mutant lacking the kinase subunit had a thinner cell wall in transmission electron micrographs as compared to wild type...
December 28, 2016: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28051854/homogeneous-transition-metal-catalysis-of-acceptorless-dehydrogenative-alcohol-oxidation-applications-in-hydrogen-storage-and-to-heterocycle-synthesis
#5
Robert H Crabtree
The different types of acceptorless alcohol dehydrogenation (AAD) reactions are discussed, followed by the catalysts and mechanisms involved. Special emphasis is put on the common appearance in AAD of pincer ligands, of noninnocent ligands, and of outer sphere mechanisms. Early work emphasized precious metals, mainly Ru and Ir, but interest in nonprecious metal AAD catalysis is growing. Alcohol-amine combinations are discussed to the extent that net oxidation occurs by loss of H2. These reactions are of potential synthetic interest because they can lead to N heterocycles such as pyrroles and pyridines...
January 4, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28024698/interpreting-survival-data-from-clinical-trials-of-surgery-versus-stereotactic-body-radiation-therapy-in-operable-stage-i-non-small-cell-lung-cancer-patients
#6
Pamela Samson, Kathleen Keogan, Traves Crabtree, Graham Colditz, Stephen Broderick, Varun Puri, Bryan Meyers
OBJECTIVES: To identify the variability of short- and long-term survival outcomes among closed Phase III randomized controlled trials with small sample sizes comparing SBRT (stereotactic body radiation therapy) and surgical resection in operable clinical Stage I non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Clinical Stage I NSCLC patients who underwent surgery at our institution meeting the inclusion/exclusion criteria for STARS (Randomized Study to Compare CyberKnife to Surgical Resection in Stage I Non-small Cell Lung Cancer), ROSEL (Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer), or both were identified...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28024648/extent-of-lymphadenectomy-is-associated-with-improved-overall-survival-after-esophagectomy-with-or-without-induction%C3%A2-therapy
#7
Pamela Samson, Varun Puri, Stephen Broderick, G Alexander Patterson, Bryan Meyers, Traves Crabtree
BACKGROUND: National Comprehensive Cancer Network (NCCN) guidelines recommend sampling 15 or more lymph nodes during esophagectomy. The proportion of patients meeting this guideline is unknown, as is its influence on overall survival (OS). METHODS: Univariate analysis and logistic regression were performed to identify variables associated with sampling 15 or more lymph nodes among patients undergoing esophagectomy in the National Cancer Data Base (NCDB). The NCCN guideline was evaluated in Cox proportional hazards modeling, along with alternative lymph node thresholds...
December 23, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28010051/qmg-and-mg-adl-correlations-study-of-eculizumab-treatment-of-myasthenia-gravis
#8
James F Howard, Miriam Freimer, Fanny O'Brien, Jing Jing Wang, Stephen R Collins, John T Kissel, Laura Herbelin, April L McVey, Mazen M Dimachkie, Mamatha Pasnoor, Debbie Lu, Alexander Waltz, Vinay Chaudhry, Andrea Corse, Elizabeth Mosmiller, Caroline Klein, Manisha Chopra, Elizabeth Richardson, Janice M Massey, Lisa D Hobson-Webb, Jeffrey Guptill, Wendy King, Annabel K Wang, Kaveh Saremi, Patricia A Tully, Denise Davis, Veronica Martin, Robert M Pascuzzi, Sandy Guingrich, Angela Micheels, Michael Pulley, Kenneth Hentschel, Lisa Smith, Rhonda Calhoun, James Gilchrist, George Sachs, Brigid Crabtree, Elena Kim Perez, Kenneth Gorson, Elizabeth Harrahy Cobb, Elinita Rosseto, Zaeem Siddiqi, Syed Nizamuddin Ahmed, Derrick Blackmore, Shannon Butler-Tyler, Sarah Louise Miller, Caroline Carmichael, Ted Burns, William David, Peter Donofrio, Bashar Katirji, Richard Lewis, Shin Oh, David Richman, Mark Sivak, Rup Tandan, Gil Wolfe, Shawn Bird, David Hilton-Jones
INTRODUCTION: A phase 2 study of eculizumab for treating myasthenia gravis (MG) used the quantitative myasthenia gravis score (QMG) and myasthenia gravis activities of daily living profile (MG-ADL) to evaluate baseline disease severity and treatment response. Correlations were then analyzed between these assessments. METHODS: Patients were given eculizumab or placebo during the first 16-week treatment period of the crossover study, with treatment assignments reversed for the second treatment period following a 5-week washout...
December 23, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27990176/enhanced-production-of-2-3-butanediol-by-engineered-saccharomyces-cerevisiae-through-fine-tuning-of-pyruvate-decarboxylase-and-nadh-oxidase-activities
#9
Jin-Woo Kim, Jungyeon Kim, Seung-Oh Seo, Kyoung Heon Kim, Yong-Su Jin, Jin-Ho Seo
BACKGROUND: 2,3-Butanediol (2,3-BD) is a promising compound for various applications in chemical, cosmetic, and agricultural industries. Pyruvate decarboxylase (Pdc)-deficient Saccharomyces cerevisiae is an attractive host strain for producing 2,3-BD because a large amount of pyruvate could be shunted to 2,3-BD production instead of ethanol synthesis. However, 2,3-BD yield, productivity, and titer by engineered yeast were inferior to native bacterial producers because of the following metabolic limitations...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27983708/the-hk2-dependent-warburg-effect-and-mitochondrial-oxidative-phosphorylation-in-cancer-targets-for-effective-therapy-with-3-bromopyruvate
#10
REVIEW
Paweł Lis, Mariusz Dyląg, Katarzyna Niedźwiecka, Young H Ko, Peter L Pedersen, Andre Goffeau, Stanisław Ułaszewski
This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the "Warburg" and "Crabtree" effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the "Warburg effect" and cancer cell immortalization. The second discovery relates to the finding that cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the "Warburg effect", and the remaining 40% is derived from mitochondrial oxidative phosphorylation...
December 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27960326/high-oxidation-state-iridium-mono-%C3%AE-oxo-dimers-related-to-water-oxidation-catalysis
#11
Liam S Sharninghausen, Shashi Bhushan Sinha, Dimitar Y Shopov, Bonnie Choi, Brandon Q Mercado, Xavier Roy, David Balcells, Gary W Brudvig, Robert H Crabtree
The highly active iridium "blue solution" chemical and electrochemical water oxidation catalyst obtained from Cp*IrL(OH) precursors (L = 2-pyridyl-2-propanoate) has been difficult to characterize as no crystal structure can be obtained because of the multiplicity of geometrical isomers present. Other data suggest complete loss of the Cp* ligand and the formation of a LIr-O-IrL unit. We have now developed a route to a series of well-defined Ir(IV,IV) mono-μ-oxo dimers, containing the closely related L2Ir-O-IrL2 unit...
December 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27956613/twenty-first-century-approaches-to-ancient-problems-climate-and-society
#12
Jade A d'Alpoim Guedes, Stefani A Crabtree, R Kyle Bocinsky, Timothy A Kohler
By documenting how humans adapted to changes in their environment that are often much greater than those experienced in the instrumental record, archaeology provides our only deep-time laboratory for highlighting the circumstances under which humans managed or failed to find to adaptive solutions to changing climate, not just over a few generations but over the longue durée Patterning between climate-mediated environmental change and change in human societies has, however, been murky because of low spatial and temporal resolution in available datasets, and because of failure to model the effects of climate change on local resources important to human societies...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27943522/no-benefit-of-ultrasound-guided-transversus-abdominis-plane-tap-blocks-over-local-anaesthetic-wound-infiltration-in-elective-laparoscopic-colonic-surgery-results-of-a-double-blind-randomised-controlled-trial
#13
A Rashid, K J Gorissen, F Ris, M P Gosselink, J R Shorthouse, A D Smith, J J Pandit, I Lindsey, N Crabtree
AIM: Advances in laparoscopic techniques combined with enhanced recovery pathways have led to faster recuperation and discharge after colorectal surgery. Peripheral nerve blockade using Transversus Abdominis Plane (TAP) blocks reduce opioid requirements and provide better analgesia than inactive controls for laparoscopic colectomies. This double-blind randomized study was performed comparing TAP blocks using Bupivacaine to standardised wound infiltration with local anaesthetic (LA). METHODS: 71 Patients were randomised between either TAP-block or wound infiltration...
December 10, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27941796/dynamics-of-baf-polycomb-complex-opposition-on-heterochromatin-in-normal-and-oncogenic-states
#14
Cigall Kadoch, Robert T Williams, Joseph P Calarco, Erik L Miller, Christopher M Weber, Simon M G Braun, John L Pulice, Emma J Chory, Gerald R Crabtree
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the underlying mechanisms remain unclear, owing largely to a lack of assays to assess BAF function in living cells. To address this, we have developed a widely applicable recruitment assay system through which we find that BAF opposes PRC by rapid, ATP-dependent eviction, leading to the formation of accessible chromatin...
December 12, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27941795/smarca4-atpase-mutations-disrupt-direct-eviction-of-prc1-from-chromatin
#15
Benjamin Z Stanton, Courtney Hodges, Joseph P Calarco, Simon M G Braun, Wai Lim Ku, Cigall Kadoch, Keji Zhao, Gerald R Crabtree
Trithorax-group proteins and their mammalian homologs, including those in BAF (mSWI/SNF) complexes, are known to oppose the activity of Polycomb repressive complexes (PRCs). This opposition underlies the tumor-suppressive role of BAF subunits and is expected to contribute to neurodevelopmental disorders. However, the mechanisms underlying opposition to Polycomb silencing are poorly understood. Here we report that recurrent disease-associated mutations in BAF subunits induce genome-wide increases in PRC deposition and activity...
December 12, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27939175/synthesis-characterization-and-in-vitro-sar-evaluation-of-n-n-bis-arylmethyl-c-2-alkyl-substituted-imidazolium-salts
#16
Michael A DeBord, Patrick O Wagers, Steven R Crabtree, Claire A Tessier, Matthew J Panzner, Wiley J Youngs
A series of C(2)-alkyl substituted N,N'-bis(arylmethyl)imidazolium salts were synthesized, characterized, and tested for their in vitro anti-cancer activity against multiple non-small cell lung cancer cell lines by our group and the National Cancer Institute's-60 human tumor cell line screen to establish a structure-activity relationship. Compounds are related to previously published N,N'-bis(arylmethyl)imidazolium salts but utilize the historical quinoline motif and anion effects to increase the aqueous solubility...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27938376/results-of-a-participatory-needs-assessment-demonstrate-an-opportunity-to-involve-people-who-use-alcohol-in-drug-user-activism-and-harm-reduction
#17
Alexis Crabtree, Nicole Latham, Lorna Bird, Jane Buxton
BACKGROUND: Drug users' organizations have made progress in recent years in advocating for the health and human rights of people who use illicit drugs but have historically not emphasized the needs of people who drink alcohol. METHODS: This paper reports on a qualitative participatory needs assessment with people who use illicit substances in British Columbia, Canada. We held workshops in 17 communities; these were facilitated by people who use illicit drugs, recorded with ethnographic fieldnotes, and analyzed using critical theory...
December 9, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27931852/the-baf45a-phf10-subunit-of-swi-snf-like-chromatin-remodeling-complexes-is-essential-for-hematopoietic-stem-cell-maintenance
#18
Veneta Krasteva, Gerald R Crabtree, Julie A Lessard
The ability of hemopoietic stem cells to self-renew and differentiate into downstream lineages is dependent on specialized chromatin environments that establish and maintain stage-specific patterns of gene expression. However, the epigenetic factors responsible for mediating these regulatory events remain poorly defined. Here we provide evidence that BAF45a/PHF10, a subunit of SWI/SNF-like chromatin remodeling complexes, is essential for adult hemopoietic stem cell (HSC) maintenance and myeloid lineage development...
December 5, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27896433/continuous-daily-assessment-of-multiple-sclerosis-disability-using-remote-step-count-monitoring
#19
V J Block, A Lizée, E Crabtree-Hartman, C J Bevan, J S Graves, R Bove, A J Green, B Nourbakhsh, M Tremblay, P-A Gourraud, M Y Ng, M J Pletcher, J E Olgin, G M Marcus, D D Allen, B A C Cree, J M Gelfand
Disability measures in multiple sclerosis (MS) rely heavily on ambulatory function, and current metrics fail to capture potentially important variability in walking behavior. We sought to determine whether remote step count monitoring using a consumer-friendly accelerometer (Fitbit Flex) can enhance MS disability assessment. 99 adults with relapsing or progressive MS able to walk ≥2-min were prospectively recruited. At 4 weeks, study retention was 97% and median Fitbit use was 97% of days. Substudy validation resulted in high interclass correlations between Fitbit, ActiGraph and manual step count tally during a 2-minute walk test, and between Fitbit and ActiGraph (ICC = 0...
November 28, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27893810/antiviral-efficacy-of-verdinexor-in-vivo-in-two-animal-models-of-influenza-a-virus-infection
#20
Olivia Perwitasari, Scott Johnson, Xiuzhen Yan, Emery Register, Jackelyn Crabtree, Jon Gabbard, Elizabeth Howerth, Sharon Shacham, Robert Carlson, Sharon Tamir, Ralph A Tripp
Influenza A virus (IAV) causes seasonal epidemics of respiratory illness that can cause mild to severe illness and potentially death. Antiviral drugs are an important countermeasure against IAV; however, drug resistance has developed, thus new therapeutic approaches are being sought. Previously, we demonstrated the antiviral activity of a novel nuclear export inhibitor drug, verdinexor, to reduce influenza replication in vitro and pulmonary virus burden in mice. In this study, in vivo efficacy of verdinexor was further evaluated in two animal models or influenza virus infection, mice and ferrets...
2016: PloS One
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