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https://www.readbyqxmd.com/read/27896433/continuous-daily-assessment-of-multiple-sclerosis-disability-using-remote-step-count-monitoring
#1
V J Block, A Lizée, E Crabtree-Hartman, C J Bevan, J S Graves, R Bove, A J Green, B Nourbakhsh, M Tremblay, P-A Gourraud, M Y Ng, M J Pletcher, J E Olgin, G M Marcus, D D Allen, B A C Cree, J M Gelfand
Disability measures in multiple sclerosis (MS) rely heavily on ambulatory function, and current metrics fail to capture potentially important variability in walking behavior. We sought to determine whether remote step count monitoring using a consumer-friendly accelerometer (Fitbit Flex) can enhance MS disability assessment. 99 adults with relapsing or progressive MS able to walk ≥2-min were prospectively recruited. At 4 weeks, study retention was 97% and median Fitbit use was 97% of days. Substudy validation resulted in high interclass correlations between Fitbit, ActiGraph and manual step count tally during a 2-minute walk test, and between Fitbit and ActiGraph (ICC = 0...
November 28, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27893810/antiviral-efficacy-of-verdinexor-in-vivo-in-two-animal-models-of-influenza-a-virus-infection
#2
Olivia Perwitasari, Scott Johnson, Xiuzhen Yan, Emery Register, Jackelyn Crabtree, Jon Gabbard, Elizabeth Howerth, Sharon Shacham, Robert Carlson, Sharon Tamir, Ralph A Tripp
Influenza A virus (IAV) causes seasonal epidemics of respiratory illness that can cause mild to severe illness and potentially death. Antiviral drugs are an important countermeasure against IAV; however, drug resistance has developed, thus new therapeutic approaches are being sought. Previously, we demonstrated the antiviral activity of a novel nuclear export inhibitor drug, verdinexor, to reduce influenza replication in vitro and pulmonary virus burden in mice. In this study, in vivo efficacy of verdinexor was further evaluated in two animal models or influenza virus infection, mice and ferrets...
2016: PloS One
https://www.readbyqxmd.com/read/27872659/whole-genome-de-novo-sequencing-combined-with-rna-seq-analysis-reveals-unique-genome-and-physiological-features-of-the-amylolytic-yeast-saccharomycopsis-fibuligera-and-its-interspecies-hybrid
#3
Jin Ho Choo, Chang Pyo Hong, Jae Yun Lim, Jeong-Ah Seo, Young-Suk Kim, Dong Wook Lee, Sin-Gi Park, Gir Won Lee, Emily Carroll, Yin-Won Lee, Hyun Ah Kang
BACKGROUND: Genomic studies on fungal species with hydrolytic activity have gained increased attention due to their great biotechnological potential for biomass-based biofuel production. The amylolytic yeast Saccharomycopsis fibuligera has served as a good source of enzymes and genes involved in saccharification. Despite its long history of use in food fermentation and bioethanol production, very little is known about the basic physiology and genomic features of S. fibuligera. RESULTS: We performed whole-genome (WG) de novo sequencing and complete assembly of S...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27872359/child-sleep-coaches-current-state-and-future-directions
#4
Jodi A Mindell, Judith A Owens, Debra Babcock, Valerie McLaughlin Crabtree, David Ingram
Given the genuine gaps in the availability of clinical sleep services for children, sleep coaching as a field has emerged and appears to be significantly increasing. Sleep coaches are typically individuals who provide individualized services, often via the Internet or phone, to families of infants and young children (and increasingly to older children, adolescents, and adults as well) with sleep problems. At this time, there is no universally accepted definition of sleep coach, nor are there clear guidelines regarding educational background, training requirements, scope of practice, or credentialing...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27837445/predictors-of-fatigue-and-poor-sleep-in-adult-survivors-of-childhood-hodgkin-s-lymphoma-a-report-from-the-childhood-cancer-survivor-study
#5
Amanda M Rach, Valerie McLaughlin Crabtree, Tara M Brinkman, Lonnie Zeltzer, Jordan Gilleland Marchak, Deokumar Srivastava, Brooklee Tynes, Jin-Shei Lai, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
PURPOSE: Survivors of pediatric Hodgkin's lymphoma (HL) are at risk for a number of debilitating late effects. Excessive fatigue and poor sleep quality are primary complaints of HL survivors. Understanding the emotional and physical factors that influence fatigue and sleep quality may provide opportunities for intervention to improve health-related quality of life for HL survivors. METHODS: Data from 751 adult survivors of childhood HL who participated in the Childhood Cancer Survivor Study (CCSS) from 2000-2002 were analyzed...
November 12, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27832914/l-proline-gaba-synthesis-and-gamma-oscillations-in-schizophrenia
#6
David W Volk, Guillermo Gonzalez-Burgos, David A Lewis
Altered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma frequency oscillations and cognitive deficits in schizophrenia. Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillations in a manner that mimics schizophrenia.
November 7, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27802860/hemifacial-spasm-in-a-patient-with-basilar-artery-dolichoectasia-caused-by-uncontrolled-hypertension
#7
Gordon S Crabtree, David Gish, David Goldberg
A 47-year-old male presented with a 2-year history of hemifacial spasm. Magnetic resonance imaging performed showed his tortuous basilar artery with nerve compression, and the patient was treated conservatively with botulinum toxin injections with complete resolution of symptoms. This rare disease was caused by his long history of hypertension, which led to his major basilar artery dolichoectasia.
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27802850/impending-aortic-aneurysm-rupture-a-case-report-and-review-of-the-warning-signs
#8
David S Gish, J Austin Baer, Gordon S Crabtree, Bilal Shaikh, Shoaib B Fareedy
Abdominal aortic aneurysm (AAA) may present with subtle clinical findings. Recognition of the imaging features of an impending rupture is key for timely diagnosis. This report reviews the classic computed tomography findings of impending AAA rupture and presents a recent case which illustrates the key features.
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27774682/evaluation-of-a-prison-occupational-therapy-informal-education-program-a-pilot-study
#9
Jeffrey L Crabtree, David Ohm, Jarrod M Wall, Joseph Ray
This pilot study explored the strengths and weaknesses of an informal education program and identified elements of the program valued by participants. Participants were men living in a minimum security prison who had been incarcerated for ten or more years. The outside researcher was joined by three former program participants as co-researchers. Together, they interviewed 27 residents who completed the informal education program. Interviews were transcribed and de-identified. Researchers used the summative content analysis approach to analyze the data...
December 2016: Occupational Therapy International
https://www.readbyqxmd.com/read/27752055/genome-wide-diversity-and-gene-expression-profiling-of-babesia-microti-isolates-identify-polymorphic-genes-that-mediate-host-pathogen-interactions
#10
Joana C Silva, Emmanuel Cornillot, Carrie McCracken, Sahar Usmani-Brown, Ankit Dwivedi, Olukemi O Ifeonu, Jonathan Crabtree, Hanzel T Gotia, Azan Z Virji, Christelle Reynes, Jacques Colinge, Vidya Kumar, Lauren Lawres, Joseph E Pazzi, Jozelyn V Pablo, Chris Hung, Jana Brancato, Priti Kumari, Joshua Orvis, Kyle Tretina, Marcus Chibucos, Sandy Ott, Lisa Sadzewicz, Naomi Sengamalay, Amol C Shetty, Qi Su, Luke Tallon, Claire M Fraser, Roger Frutos, Douglas M Molina, Peter J Krause, Choukri Ben Mamoun
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis. While most cases are transmitted by Ixodes ticks, the disease may also be transmitted through blood transfusion and perinatally. A comprehensive analysis of genome composition, genetic diversity, and gene expression profiling of seven B. microti isolates revealed that genetic variation in isolates from the Northeast United States is almost exclusively associated with genes encoding the surface proteome and secretome of the parasite...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27731394/large-spin-orbit-coupling-and-helical-spin-textures-in-2d-heterostructure-pb2bis3-aute2
#11
L Fang, J Im, W DeGottardi, Y Jia, A Glatz, K A Matveev, W-K Kwok, G W Crabtree, M G Kanatzidis
Two-dimensional heterostructures with strong spin-orbit coupling have direct relevance to topological quantum materials and potential applications in spin-orbitronics. In this work, we report on novel quantum phenomena in [Pb2BiS3][AuTe2], a new 2D strong spin-orbit coupling heterostructure system. Transport measurements reveal the spin-related carrier scattering is at odds with the Abrikosov-Gorkov model due to strong spin-orbit coupling. This is consistent with our band structure calculations which reveal a large spin-orbit coupling gap of εso = 0...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27722662/controlling-the-rectification-properties-of-molecular-junctions-through-molecule-electrode-coupling
#12
Matthieu Koepf, Christopher Koenigsmann, Wendu Ding, Arunbah Batra, Christian F A Negre, Latha Venkataraman, Gary W Brudvig, Victor S Batista, Charles A Schmuttenmaer, Robert H Crabtree
The development of molecular components functioning as switches, rectifiers or amplifiers is a great challenge in molecular electronics. A desirable property of such components is functional robustness, meaning that the intrinsic functionality of components must be preserved regardless of the strategy used to integrate them into the final assemblies. Here, this issue is investigated for molecular diodes based on N-phenylbenzamide (NPBA) backbones. The transport properties of molecular junctions derived from NPBA are characterized while varying the nature of the functional groups interfacing the backbone and the gold electrodes required for break-junction measurements...
September 15, 2016: Nanoscale
https://www.readbyqxmd.com/read/27705802/cytosolic-accumulation-of-l-proline-disrupts-gaba-ergic-transmission-through-gad-blockade
#13
Gregg W Crabtree, Alan J Park, Joshua A Gordon, Joseph A Gogos
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders. Despite the strength of data linking PRODH and L-proline to neuropsychiatric diseases, targets of disease-relevant concentrations of L-proline have not been convincingly described. Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations...
October 4, 2016: Cell Reports
https://www.readbyqxmd.com/read/27665480/quality-measures-in-clinical-stage-i-non-small-cell-lung-cancer-improved-performance-is-associated-with-improved-survival
#14
Pamela Samson, Traves Crabtree, Stephen Broderick, Daniel Kreisel, A Sasha Krupnick, G Alexander Patterson, Bryan Meyers, Varun Puri
BACKGROUND: National organizations have recommended quality measures for operations in early-stage non-small cell lung cancer (NSCLC). The outcomes of adherence to these guidelines are unknown. METHODS: Information about patients who underwent an operation for clinical stage I NSCLC was abstracted from the National Cancer Database. After reviewing current guidelines, the following quality measures were selected: anatomic resection, operation within 8 weeks of diagnosis, achievement of negative surgical margins, and sampling of 10 or more lymph nodes...
September 21, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27661406/oral-health-behaviors-and-perceptions-among-college-students
#15
Rebecca Crabtree, Abigail Kirk, Moriah Moore, Sam Abraham
Oral health is a simple and important part of college students' lives but might often be overlooked or undermined because of increased stress levels and unhealthy habits associated with the college setting. Despite the challenges, college days may be one of the best times to establish lifelong healthy habits, including oral health routines. The purpose of this study was to determine the current oral care behaviors and perceptions of students at a midwestern college. This study was nonexperimental in nature with a quantitative method and a cross-sectional design, which included 126 participants...
September 21, 2016: Health Care Manager
https://www.readbyqxmd.com/read/27647111/critical-reflections-on-participatory-action-research-in-a-prison-setting-toward-occupational-justice
#16
Jeffrey L Crabtree, Jarrod M Wall, David Ohm
There is little information about prison-related occupational deprivation, and about doing research in prison. To document an occupational therapist and two prisoners' critical reflections on an informal occupational therapy education program using participatory action research (PAR), we reflect on our combined experiences of evaluating an occupational therapy program. The reflections include articulation of power differentials and examples of occupational deprivation and injustice at every stage of the program evaluation process...
September 19, 2016: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/27643532/one-step-trimethylstannylation-of-benzyl-and-alkyl-halides
#17
Jianbing Jiang, Robert H Crabtree, Gary W Brudvig
Trialkylstannanes are good leaving groups that have been used for the formation of carbon-metal bonds to electrode surfaces for analyses of single-molecule conductivity. Here, we report the multistep synthesis of two amide-containing compounds that are of interest in studies of molecular rectifiers. Each molecule has two trimethylstannyl units, one linked by a methylene and the other by an ethylene group. To account for the very different reactivities of the parent halides, a new methodology for one-step trimethylstannylation was developed and optimized...
October 7, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27627879/identification-of-target-genes-to-control-acetate-yield-during-aerobic-fermentation-with-saccharomyces-cerevisiae
#18
José Antonio Curiel, Zoel Salvadó, Jordi Tronchoni, Pilar Morales, Alda Joao Rodrigues, Manuel Quirós, Ramón Gonzalez
BACKGROUND: Aerobic fermentation of grape must, leading to respiro-fermentative metabolism of sugars, has been proposed as way of reducing alcohol content in wines. Two factors limit the usefulness of Saccharomyces cerevisiae for this application, the Crabtree effect, and excess volatile acidity under aerobic conditions. This work aimed to explore the impact on ethanol acetate production of different S. cerevisiae strains deleted for genes previously related with the Crabtree phenotype...
2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27590850/circumventing-the-crabtree-effect-a-method-to-induce-lactate-consumption-and-increase-oxidative-phosphorylation-in-cell-culture
#19
Alexandra I Mot, Jeffrey R Liddell, Anthony R White, Peter J Crouch
Most cells grown in glucose-containing medium generate almost all their ATP via glycolysis despite abundant oxygen supply and functional mitochondria, a phenomenon known as the Crabtree effect. By contrast, most cells within the body rely on mitochondrial oxidative phosphorylation (OXPHOS) to generate the bulk of their energy supply. Thus, when utilising the accessibility of cell culture to elucidate fundamental elements of mitochondria in health and disease, it is advantageous to adopt culture conditions under which the cells have greater reliance upon OXPHOS for the supply of their energy needs...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27588498/acquisition-of-an-oncogenic-fusion-protein-serves-as-an-initial-driving-mutation-by-inducing-aneuploidy-and-overriding-proliferative-defects
#20
Jacob M Loupe, Patrick J Miller, Benjamin P Bonner, Elaine C Maggi, Jyothi Vijayaraghavan, Jovanny Zabaleta, Christopher M Taylor, Fern Tsien, Judy S Crabtree, Andrew D Hollenbach
While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not clear whether it is the cause or effect of malignant transformation. The childhood sarcoma, Alveolar Rhabdomyosarcoma (ARMS), is primarily defined by the t(2;13)(q35;q14) translocation, creating the PAX3-FOXO1 fusion protein...
August 30, 2016: Oncotarget
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