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https://www.readbyqxmd.com/read/28829991/pro-inflammatory-fatty-acid-profile-and-colorectal-cancer-risk-a-mendelian-randomisation-analysis
#1
Sebastian May-Wilson, Amit Sud, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, David Fisher, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
BACKGROUND: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk. METHODS: We analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels...
August 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28826373/fatty-acids-and-nlrp3-inflammasome-mediated-inflammation-in-metabolic-tissues
#2
Jessica C Ralston, Claire L Lyons, Elaine B Kennedy, Anna M Kirwan, Helen M Roche
Worldwide obesity rates have reached epidemic proportions and significantly contribute to the growing prevalence of metabolic diseases. Chronic low-grade inflammation, a hallmark of obesity, involves immune cell infiltration into expanding adipose tissue. In turn, obesity-associated inflammation can lead to complications in other metabolic tissues (e.g., liver, skeletal muscle, pancreas) through lipotoxicity and inflammatory signaling networks. Importantly, although numerous signaling pathways are known to integrate metabolic and inflammatory processes, the nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is now noted to be a key regulator of metabolic inflammation...
August 21, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28823135/the-meat-quality-muscle-fiber-characteristics-and-fatty-acid-profile-in-jinjiang-and-f1-simmental%C3%A2-%C3%A3-%C3%A2-jinjiang-yellow-cattle
#3
Yue Zheng, Shizhi Wang, Peishi Yan
Objective: This study compared the meat quality, muscle fiber characteristics, and fatty acids between Jinjiang yellow cattle (JJ) and F1 Simmental × Jinjiang yellow cattle (SJ) which were offered the same diet. Methods: Six JJ and six SJ individuals were reared and fattened from 10 to 26 months of age. After feeding, the highrib (HR), ribeye (RB) and tenderloin (TL) samples were taken from the carcass for meat quality evaluations. Results: The results showed that growth performance of SJ was higher than that of JJ (higher live weight and average daily gain), and the hot carcass weight of SJ was higher than that of JJ (P < 0...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28821754/discovery-of-potential-biomarkers-in-human-melanoma-cells-with-different-metastatic-potential-by-metabolic-and-lipidomic-profiling
#4
Hye-Youn Kim, Hwanhui Lee, So-Hyun Kim, Hanyong Jin, Jeehyeon Bae, Hyung-Kyoon Choi
Malignant melanoma, characterized by its ability to metastasize to other organs, is responsible for 90% of skin cancer mortality. To investigate alterations in the cellular metabolome and lipidome related to melanoma metastasis, gas chromatography-mass spectrometry (GC-MS) and direct infusion-mass spectrometry (DI-MS)-based metabolic and lipidomic profiling were performed on extracts of normal human melanocyte (HEMn-LP), low metastatic melanoma (A375, G361), and highly metastatic melanoma (A2058, SK-MEL-28) cell lines...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821393/nutritional-status-brain-network-organization-and-general-intelligence
#5
Marta K Zamroziewicz, M Tanveer Talukdar, Chris E Zwilling, Aron K Barbey
The high energy demands of the brain underscore the importance of nutrition in maintaining brain health and further indicate that aspects of nutrition may optimize brain health, in turn enhancing cognitive performance. General intelligence represents a critical cognitive ability that has been well characterized by cognitive neuroscientists and psychologists alike, but the extent to which a driver of brain health, namely nutritional status, impacts the neural mechanisms that underlie general intelligence is not understood...
August 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28814390/the-physiological-and-metabolic-differences-between-visceral-and-subcutaneous-adipose-tissues-in-nile-tilapia-oreochromis-niloticus
#6
Ya-Wen Wang, Ji-Lei Zhang, Jian-Gang Jiao, Xiao-Xia Du, Samwel Mchele Limbu, Fang Qiao, Mei-Ling Zhang, Dong-Liang Li, Zhen-Yu Du
BACKGROUND: Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT) have different structures and metabolic functions, and play different roles in the regulation of mammal systemic endocrine. However, little is known about morphology and physiological and metabolic functions between VAT and SCAT in fish. METHODS: We compared the morphological, physiological and biochemical characteristics of VAT and SCAT in Nile Tilapia and measured their functions in energy intake flux, lipolytic ability, and gene expression patterns...
August 16, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#7
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28812146/engineering-rhodosporidium-toruloides-for-the-production-of-very-long-chain-monounsaturated-fatty-acid-rich-oils
#8
Sandy Fillet, Carmen Ronchel, Carla Callejo, María-José Fajardo, Helena Moralejo, José L Adrio
Erucic acid (cis-docosa-13-enoic acid, C22:1∆13) and nervonic acid (cis-tetracosa-15-enoic acid, C24:1 ∆15) are important renewable feedstocks in plastic, cosmetic, nylon, and lubricant industries. Furthermore, nervonic acid is also applied to the treatment of some neurological diseases. However, the production of these two very long-chain fatty acids (VLCFA) is very limited as both are not present in the main vegetable oils (e.g., soybean, rapeseed, sunflower, and palm). Ectopic integration and heterologous expression of fatty acid elongases (3-ketoacyl-CoA synthases, KCS) from different plants in Rhodosporidium toruloides resulted in the de novo synthesis of erucic acid and nervonic acid in this oleaginous yeast...
August 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28812011/oil-characterization-and-lipids-class-composition-of-pomegranate-seeds
#9
Zahra Amri, Houda Lazreg-Aref, Manel Mekni, Sinda El-Gharbi, Olfa Dabbaghi, Beligh Mechri, Mohamed Hammami
This study aims to investigate the physicochemical characteristics, phenolics content, and oil composition of pomegranate oil seeds (PSO). Quality indices, pigments, phenolics content, and antioxidant activity were determined. PSO was fractioned into polar lipids: glycolipids (GL) and phospholipids (PL). Sterols profile and fatty acids composition of total lipids (TL), GL, and PL were determined by GC/FID. The free acidity, the peroxide value, and the specific extinction coefficients were, respectively, 1.69%, 3...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803653/effect-of-dietary-intake-of-saturated-fatty-acids-on-the-development-of-atrial-fibrillation-and-the-effect-of-replacement-of-saturated-with-monounsaturated-and-polyunsaturated-fatty-acids
#10
Pia Thisted Dinesen, Albert Marni Joensen, Thomas Andersen Rix, Anne Tjønneland, Erik Berg Schmidt, Søren Lundbye-Christensen, Kim Overvad
The aim of the present study was to explore substitution of intake of saturated fatty acids (FAs) with monounsaturated and polyunsaturated FAs and incident atrial fibrillation (AF) in men and women. A total of 57,053 Danish participants aged 50 to 64 years were enrolled in the Diet, Cancer and Health cohort study in 1993 to 1997 and completed a semiquantitative food frequency questionnaire at baseline. Follow-up was registry-based and data were analyzed using Cox proportional hazards regression. The statistical model was formulated in such a way that 1 g/day of saturated FAs was replaced with 1 g/day of monounsaturated or polyunsaturated FAs while keeping total fat intake, total energy intake, and energy intake from protein and carbohydrates constant...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28803023/consumer-acceptance-of-dairy-products-with-a-saturated-fatty-acid-reduced-monounsaturated-fatty-acid-enriched-content
#11
Oonagh Markey, Kallis Souroullas, Colette C Fagan, Kirsty E Kliem, Dafni Vasilopoulou, Kim G Jackson, David J Humphries, Alistair S Grandison, David I Givens, Julie A Lovegrove, Lisa Methven
Agriculture-based reformulation initiatives, including oleic acid-rich lipid supplementation of the dairy cow diet, provide a novel means for reducing intake of saturated fatty acids (SFA) at a population level. In a blinded manner, this study evaluated the consumer acceptance of SFA-reduced, monounsaturated fatty acid-enriched (modified) milk, Cheddar cheese, and butter when compared with control and commercially available comparative samples. The effect of providing nutritional information about the modified cheese was also evaluated...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28797843/blockade-of-stearoyl-coa-desaturase-1-activity-reverts-resistance-to-cisplatin-in-lung-cancer-stem-cells
#12
Maria Elena Pisanu, Alessia Noto, Claudia De Vitis, Stefania Morrone, Giosuè Scognamiglio, Gerardo Botti, Federico Venuta, Daniele Diso, Ziga Jakopin, Fabrizio Padula, Alberto Ricci, Salvatore Mariotta, Maria Rosaria Giovagnoli, Enrico Giarnieri, Ivano Amelio, Massimiliano Agostini, Gerry Melino, Gennaro Ciliberto, Rita Mancini
Poor prognosis in lung cancer has been attributed to the presence of lung cancer stem cells (CSCs) which resist chemotherapy and cause disease recurrence. Hence, the strong need to identify mechanisms of chemoresistance and to develop new combination therapies. We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways β-catenin and YAP/TAZ...
August 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28795322/discarded-seeds-from-red-pepper-capsicum-annum-processing-industry-as-a-sustainable-source-of-high-added-value-compounds-and-edible-oil
#13
Samia Azabou, Fadia Ben Taheur, Mourad Jridi, Mohamed Bouaziz, Moncef Nasri
The chemical composition and the antioxidant properties of Capsicum annum discarded seeds from processing industry with their corresponding extracted oil were investigated. C. annum seeds had high levels of crude proteins (18.30%), crude oil (11.04%), and dietary fibers (60.96%). The lipophilic fraction of C. annum seeds showed higher radical scavenging activity compared to their hydrophilic fraction, while this latter exhibited the highest reducing power. The results of fatty acid composition showed that fatty acids present in C...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28793994/dietary-fatty-acid-intake-after-myocardial-infarction-a-theoretical-substitution-analysis-of-the-alpha-omega-cohort
#14
Famke Jm Mölenberg, Janette de Goede, Anne J Wanders, Peter L Zock, Daan Kromhout, Johanna M Geleijnse
Background: Replacement of saturated fatty acids (SFAs) with unsaturated fatty acids (UFAs), especially polyunsaturated fatty acids (PUFAs), has been associated with a lower risk of ischemic heart disease (IHD). Whether this replacement is beneficial for drug-treated patients with cardiac disease is not yet clear.Objective: In a prospective study of Dutch patients with cardiac disease (Alpha Omega Cohort), we examined the risk of cardiovascular disease (CVD) and IHD mortality when the sum of SFAs and trans fatty acids (TFAs) was theoretically replaced by total UFAs, PUFAs, or cis monounsaturated fatty acids (MUFAs)...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28793941/estimates-of-genetic-parameters-for-fatty-acid-compositions-in-the-longissimus-dorsi-muscle-of-hanwoo-cattle
#15
M S A Bhuiyan, D H Lee, H J Kim, S H Lee, S H Cho, B S Yang, S D Kim
We estimated the heritabilities (h 2) and genetic and phenotypic correlations among individual and groups of fatty acids, as well as their correlations with six important carcass and meat-quality traits in Korean Hanwoo cattle. Meat samples were collected from the longissimus dorsi muscles of 1000 Hanwoo steers that were 30-month-old (progeny of 85 proven Hanwoo bulls) to determine intramuscular fatty acid profiles. Phenotypic data on carcass weight (CWT), eye muscle area (EMA), back fat thickness (BFT), marbling score (MS), Warner-Bratzler shear force (WBSF) and intramuscular fat content (IMF) were also investigated using this half-sib population...
August 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28793772/effect-of-dietary-lipids-on-endotoxemia-influences-postprandial-inflammatory-response
#16
Javier López-Moreno, Sonia García-Carpintero, Rosa Jimenez-Lucena, Carmen Haro, Oriol A Rangel-Zúñiga, Ruth Blanco-Rojo, Elena M Yubero-Serrano, Francisco J Tinahones, Javier Delgado-Lista, Pablo Pérez-Martínez, Helen M Roche, José López-Miranda, Antonio Camargo
Metabolic syndrome (MetS) results in postprandial metabolic alterations that predisposes one to a state of chronic low-grade inflammation and increased oxidative stress. We aimed to assess the effect of the consumption of the quantity and quality of dietary fat on fasting and postprandial plasma lipopolysaccharides (LPS). A subgroup of 75 subjects with metabolic syndrome was randomized to receive 1 of 4 diets: HSFA, rich in saturated fat; HMUFA, rich in monounsaturated fat; LFHCC n-3, low-fat, rich in complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids; LFHCC low-fat, rich in complex carbohydrate diet supplemented with placebo, for 12 weeks each...
August 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28792239/improving-the-nutritional-quality-and-shelf-life-of-broiler-meat-by-feeding-diets-supplemented-with-fermented-pomegranate-punica-granatum-l-by-products
#17
S T Ahmed, S-Y Ko, C-J Yang
1. Four experimental diets containing 0, 0.5, 1.0 and 2.0% fermented pomegranate by-products (FPB) were supplied to 320 day-old broilers to evaluate the effects of FPB on growth performance, nutritional composition, fatty acid profile and oxidative stability of meat. 2. Dietary supplementation of FPB linearly increased the weight gain and feed intake of broilers with linear reduction in feed conversion ratio. 3. The crude protein, iron, magnesium, and sodium content were linearly higher, whereas cholesterol was linearly lower in the breast meat of FPB supplemented broilers...
August 9, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28780859/photoinduced-carboborative-ring-contraction-enables-regio-and-stereoselective-synthesis-of-multiply-substituted-five-membered-carbocycles-and-heterocycles
#18
Shengfei Jin, Vu T Nguyen, Hang T Dang, Dat P Nguyen, Hadi D Arman, Oleg V Larionov
We report herein a photoinduced carboborative ring contraction of monounsaturated six-membered carbocycles and heterocycles. The reaction produces substituted five-membered ring systems stereoselectively and on preparative scales. The products feature multiple stereocenters, including contiguous quaternary carbons. We show that the reaction can serve as a synthetic platform for ring system alteration of natural products. The reaction can also be used in natural product synthesis. A concise total synthesis of artalbic acid has been enabled by a sequence of photoinduced carboborative ring contraction, Rauhut-Currier reaction, and nitrilase-catalyzed hydrolysis...
August 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28780350/effect-of-elovl3-expression-on-bovine-skeletal-muscle-derived-satellite-cell-differentiation
#19
Dan Liu, Jia-Hui Xu, Hui-Li Tong, Shu-Feng Li, Yun-Qin Yan
ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 in bovine cells remain unclear. Herein, we aimed to elucidate the effect of the ELOVL3 on the differentiation of bovine skeletal muscle-derived satellite cells (MDSCs). Western blot and immunofluorescence analyses were used for elucidating ELOVL3 expression pattern in bovine MDSCs during differentiation in vitro...
August 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28777292/influence-of-a-virgin-olive-oil-versus-butter-plus-cholesterol-enriched-diet-on-testicular-enzymatic-activities-in-adult-male-rats
#20
Germán Domínguez-Vías, Ana Belén Segarra, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto
The aim of the present work was to improve our knowledge on the mechanisms underlying the beneficial or deleterious effects on testicular function of the so-called Mediterranean and Western diet by analyzing glutamyl aminopeptidase (GluAP), gamma glutamyl transpeptidase (GGT) and dipeptidyl peptidase IV (DPP IV) activities in testis, as enzymes involved in testicular function. Male Wistar rats (6 months old) were fed for 24 weeks with three different diets: standard (S), an S diet supplemented with virgin-olive-oil (20%) (VOO), or a S diet enriched with butter (20%) plus cholesterol (0...
August 4, 2017: International Journal of Molecular Sciences
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