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reticulon 4b

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https://www.readbyqxmd.com/read/27132996/reticulon-4b-nogo-b-acts-as-a-molecular-linker-between-microtubules-and-actin-cytoskeleton-in-vascular-smooth-muscle-cells
#1
Juan A Rodríguez-Feo, Julio Gallego-Delgado, Marta Puerto, Francisco Wandosell, Julio Osende
No abstract text is available yet for this article.
August 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25907690/a-new-role-for-reticulon-4b-nogo-b-in-the-intestinal-epithelial-barrier-function-and-inflammatory-bowel-disease
#2
Juan Antonio Rodríguez-Feo, Marta Puerto, Carolina Fernández-Mena, Cristina Verdejo, José Manuel Lara, María Díaz-Sánchez, Emilio Álvarez, Javier Vaquero, Ignacio Marín-Jiménez, Rafael Bañares, Luis Menchén
Inflammatory bowel disease (IBD) is characterized by an impaired intestinal barrier function. We aimed to investigate the role of reticulon-4B (RTN-4B/NOGO-B), a structural protein of the endoplasmic reticulum, in intestinal barrier function and IBD. We used immunohistochemistry, confocal microscopy, real-time PCR, and Western blotting to study tissue distribution and expression levels of RTN-4B/NOGO-B in control and IBD samples from mouse and humans. We also targeted RTN-4B/NOGO-B using siRNAs in cultured human intestinal epithelial cell (IECs)...
June 15, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/24898729/reticulon-3-interacts-with-ns4b-of-the-hepatitis-c-virus-and-negatively-regulates-viral-replication-by-disrupting-ns4b-self-interaction
#3
Ming-Jhan Wu, Po-Yuan Ke, John T-A Hsu, Chau-Ting Yeh, Jim-Tong Horng
The non-structural protein 4B (NS4B) of the hepatitis C virus (HCV) is an endoplasmic reticulum (ER) membrane protein comprising two consecutive amphipathic α-helical domains (AH1 and AH2). Its self-oligomerization via the AH2 domain is required for the formation of the membranous web that is necessary for viral replication. Previously, we reported that the host-encoded ER-associated reticulon 3 (RTN3) protein is involved in the formation of the replication-associated membranes of (+)RNA enteroviruses during viral replication...
November 2014: Cellular Microbiology
https://www.readbyqxmd.com/read/24372562/nogo-b-expression-in-arterial-intima-is-impeded-in-the-early-stages-of-atherosclerosis-in-humans
#4
Katarzyna Drożdż, Irmina Grzegorek, Magdalena Chmielewska, Agnieszka Gomułkiewicz, Karolina Jabłońska, Aleksandra Piotrowska, Maciej Karczewski, Dariusz Janczak, Dariusz Patrzałek, Piotr Dzięgiel, Andrzej Szuba
Nogo-B (Reticulon 4B) is considered to be a novel vascular marker, which may have a protective role in injury-induced neointima formation and atherosclerosis. Nogo A/B is found to be crucial for monocyte/macrophage recruitment in acute inflammation and it is expressed in CD68 + macrophages. We hypothesize that macrophage infiltration in atherosclerosis is not dependent on Nogo-B expression in arterial wall. We have assessed Nogo-B expression and macrophage accumulation in the iliac arteries of healthy organ donors and organ donors with cardiovascular risk factors...
September 2014: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/23770576/nitric-oxide-scavenging-causes-remodeling-of-the-endoplasmic-reticulum-golgi-apparatus-and-mitochondria-in-pulmonary-arterial-endothelial-cells
#5
Jason E Lee, Huijuan Yuan, Feng-Xia Liang, Pravin B Sehgal
The dependence of the structure and function of cytoplasmic organelles in endothelial cells on constitutively produced intracellular nitric oxide (NO) remains largely unexplored. We previously reported fragmentation of the Golgi apparatus in cells exposed to NO scavengers or after siRNA-mediated knockdown of eNOS. Others have reported increased mitochondrial fission in response to an NO donor. Functionally, we previously reported that bovine pulmonary arterial endothelial cells (PAECs) exposed to the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO) developed a prosecretory phenotype characterized by prolonged secretion of soluble proteins...
September 1, 2013: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/23313137/absence-of-nogo-b-reticulon-4b-facilitates-hepatic-stellate-cell-apoptosis-and-diminishes-hepatic-fibrosis-in-mice
#6
Keitaro Tashiro, Ayano Satoh, Teruo Utsumi, Chuhan Chung, Yasuko Iwakiri
Nogo-B (reticulon 4B) accentuates hepatic fibrosis and cirrhosis, but the mechanism remains unclear. The aim of this study was to identify the role of Nogo-B in hepatic stellate cell (HSC) apoptosis in cirrhotic livers. Cirrhosis was generated by carbon tetrachloride inhalation in wild-type (WT) and Nogo-A/B knockout (Nogo-B KO) mice. HSCs were isolated from WT and Nogo-B KO mice and cultured for activation and transformation to myofibroblasts (MF-HSCs). Human hepatic stellate cells (LX2 cells) were used to assess apoptotic responses of activated HSCs after silencing or overexpressing Nogo-B...
March 2013: American Journal of Pathology
https://www.readbyqxmd.com/read/23299899/reticulon-4b-nogo-b-facilitates-hepatocyte-proliferation-and-liver-regeneration-in-mice
#7
Lili Gao, Teruo Utsumi, Keitaro Tashiro, Bo Liu, Dahai Zhang, E Scott Swenson, Yasuko Iwakiri
UNLABELLED: Nogo-B, also known as reticulon 4B, promotes liver fibrosis and cirrhosis by facilitating the transforming growth factor β (TGF-β) signaling pathway in activated hepatic stellate cells. The aim of this study was to determine the role of Nogo-B in hepatocyte proliferation and liver regeneration. Partial hepatectomy (PHx, 70% resection) was performed in male wild-type (WT) and Nogo-A/B knockout mice (referred to as Nogo-B KO mice). Remnant livers were isolated 2 hours, 5 hours, and 1, 2, 3, 7, and 14 days after PHx...
May 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/21480333/reticulon-4b-nogo-b-is-a-novel-regulator-of-hepatic-fibrosis
#8
Dahai Zhang, Teruo Utsumi, Hui-Chun Huang, Lili Gao, Panjamaporn Sangwung, Chuhan Chung, Kazunori Shibao, Kohji Okamoto, Koji Yamaguchi, Roberto J Groszmann, Levente Jozsef, Zhengrong Hao, William C Sessa, Yasuko Iwakiri
UNLABELLED: Nogo-B, also known as Reticulon 4B, plays important roles in vascular injuries. Its function in the liver is not understood. The aim of this study was to characterize Nogo-B in liver fibrosis and cirrhosis. Nogo-B distribution was assessed in normal and cirrhotic human liver sections. We also determined the levels of liver fibrosis in wild-type (WT) and Nogo-A/B knockout (NGB KO) mice after sham operation or bile duct ligation (BDL). To investigate the mechanisms of Nogo-B's involvement in fibrosis, hepatic stellate cells were isolated from WT and NGB KO mice and transformed into myofibroblasts...
April 2011: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/21183689/endothelial-reticulon-4b-nogo-b-regulates-icam-1-mediated-leukocyte-transmigration-and-acute-inflammation
#9
Annarita Di Lorenzo, Thomas D Manes, Alberto Davalos, Paulette L Wright, William C Sessa
The reticulon (Rtn) family of proteins are localized primarily to the endoplasmic reticulum (ER) of most cells. The Rtn-4 family, (aka Nogo) consists of 3 splice variants of a common gene called Rtn-4A, Rtn-4B, and Rtn-4C. Recently, we identified the Rtn-4B (Nogo-B) protein in endothelial and smooth muscle cells of the vessel wall, and showed that Nogo-B is a regulator of cell migration in vitro and vascular remodeling and angiogenesis in vivo. However, the role of Nogo-B in inflammation is still largely unknown...
February 17, 2011: Blood
https://www.readbyqxmd.com/read/20975041/epithelial-reticulon-4b-nogo-b-is-an-endogenous-regulator-of-th2-driven-lung-inflammation
#10
Paulette L Wright, Jun Yu, Y P Peter Di, Robert J Homer, Geoffrey Chupp, Jack A Elias, Lauren Cohn, William C Sessa
Nogo-B is a member of the reticulon family of proteins (RTN-4B) that is highly expressed in lung tissue; however, its function remains unknown. We show that mice with Th2-driven lung inflammation results in a loss of Nogo expression in airway epithelium and smooth muscle compared with nonallergic mice, a finding which is replicated in severe human asthma. Mice lacking Nogo-A/B (Nogo-KO) display an exaggerated asthma-like phenotype, and epithelial reconstitution of Nogo-B in transgenic mice blunts Th2-mediated lung inflammation...
November 22, 2010: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/20971739/identification-and-regulation-of-reticulon-4b-nogo-b-in-renal-tubular-epithelial-cells
#11
Ethan P Marin, Gilbert Moeckel, Rafia Al-Lamki, John Bradley, Qingshang Yan, Tong Wang, Paulette L Wright, Jun Yu, William C Sessa
Nogo-B is a member of the reticulon family of proteins that has been implicated in diverse forms of vascular injury. Although Nogo-B is expressed in renal tissues, its localization and function in the kidney have not been examined. Here, we report that Nogo-B is expressed specifically in the epithelial cells of the distal nephron segments in the murine kidney. After unilateral ureteral obstruction (UUO) and ischemia/reperfusion, Nogo-B gene and protein levels increased dramatically in the kidney. This increase was driven in part by injury-induced de novo expression in proximal tubules...
December 2010: American Journal of Pathology
https://www.readbyqxmd.com/read/19805174/reticulon-4b-nogo-b-is-necessary-for-macrophage-infiltration-and-tissue-repair
#12
Jun Yu, Carlos Fernández-Hernando, Yajaira Suarez, Michael Schleicher, Zhengrong Hao, Paulette L Wright, Annarita DiLorenzo, Themis R Kyriakides, William C Sessa
Blood vessel formation during ischemia and wound healing requires coordination of the inflammatory response with genes that regulate blood vessel assembly. Here we show that the reticulon family member 4B, aka Nogo-B, is upregulated in response to ischemia and is necessary for blood flow recovery secondary to ischemia and wound healing. Mice lacking Nogo-B exhibit reduced arteriogenesis and angiogenesis that are linked to a decrease in macrophage infiltration and inflammatory gene expression in vivo. Bone marrow-derived macrophages isolated from Nogo knock-out mice have reduced spreading and chemotaxis due to impaired Rac activation...
October 13, 2009: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/19723497/nogo-b-receptor-stabilizes-niemann-pick-type-c2-protein-and-regulates-intracellular-cholesterol-trafficking
#13
Kenneth D Harrison, Robert Qing Miao, Carlos Fernandez-Hernándo, Yajaira Suárez, Alberto Dávalos, William C Sessa
The Nogo-B receptor (NgBR) is a recently identified receptor for the N terminus of reticulon 4B/Nogo-B. Other than its role in binding Nogo-B, little is known about the biology of NgBR. To elucidate a basic cellular role for NgBR, we performed a yeast two-hybrid screen for interacting proteins, using the C-terminal domain as bait, and identified Niemann-Pick type C2 protein (NPC2) as an NgBR-interacting protein. NPC2 protein levels are increased in the presence of NgBR, and NgBR enhances NPC2 protein stability...
September 2009: Cell Metabolism
https://www.readbyqxmd.com/read/16261208/-screening-and-cloning-of-hepatitis-c-virus-non-structural-protein-4b-interacting-protein-gene-in-hepatocytes
#14
Yan Liu, Jun Cheng, Gui-qin Bai, Fu-ming Yan, Shun-hua Wu, Lin Wang, Ling-xia Zhang
OBJECTIVE: To investigate biological functions of non-structural protein 4B (NS4B) of hepatitis C virus (HCV), yeast-two hybrid technique was performed to seek proteins in hepatocytes interacting with HCV NS4B. METHODS: HCV NS4B bait plasmid was constructed by ligating the NS4B gene with carrier plasmid pGBKT7 and transformed into yeast cells AH109 (type alpha). The transformed yeast cells were amplified and mated with yeast cells Y187 (alpha type) containing liver cDNA library plasmid pACT2 in 2 x YPDA medium...
September 2005: Chinese Journal of Experimental and Clinical Virology
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