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https://www.readbyqxmd.com/read/29217477/activation-of-hepatic-nogo-b-receptor-expression-a-new-anti-liver-steatosis-mechanism-of-statins
#1
Wenwen Zhang, Xiaoxiao Yang, Yuanli Chen, Wenquan Hu, Lipei Liu, Xiaomeng Zhang, Mengyang Liu, Lei Sun, Ying Liu, Miao Yu, Xiaoju Li, Luyuan Li, Yan Zhu, Qing Robert Miao, Jihong Han, Yajun Duan
Deficiency of hepatic Nogo-B receptor (NgBR) expression activates liver X receptor α (LXRα) in an adenosine monophosphate-activated protein kinase α (AMPKα)-dependent manner, thereby inducing severe hepatic lipid accumulation and hypertriglyceridemia. Statins have been demonstrated non-cholesterol lowering effects including anti-nonalcoholic fatty liver disease (NAFLD). Herein, we investigated if the anti-NAFLD function of statins depends on activation of NgBR expression. In vivo, atorvastatin protected apoE deficient or NgBR floxed, but not hepatic NgBR deficient mice, against Western diet (WD)-increased triglyceride levels in liver and serum...
December 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29196321/mt3-mmp-promotes-excitatory-synapse-formation-by-promoting-nogo-66-receptor-ectodomain-shedding
#2
Ricardo L Sanz, Gino B Ferraro, Johannes Kacervosky, Charleen Salesse, Elizabeth Gowing, Luyang Hua, Isabel Rambaldi, Francois Beaubien, Kenn Holmbeck, J F Cloutier, Martin Lévesque, Keith Murai, Alyson E Fournier
Cell surface molecules are dynamically regulated at the synapse to assemble and disassemble adhesive contacts that are important for synaptogenesis and for tuning synaptic transmission. Metalloproteinases dynamically regulate cellular behaviors through the processing of cell surface molecules. In the present study, we evaluated the role of membrane-type metalloproteinases (MT-MMPs) in excitatory synaptogenesis. We find that MT3-MMP and MT5-MMP are broadly expressed in the mouse cerebral cortex and that MT3-MMP loss-of-function interferes with excitatory synapse development in dissociated cortical neurons and in vivo We identify Nogo-66 receptor (NgR1) as an MT3-MMP substrate that is required for MT3-MMP-dependent synapse formation...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29159048/resting-state-connectivity-and-executive-functions-after-pediatric-arterial-ischemic-stroke
#3
Salome Kornfeld, Rui Yuan, Bharat B Biswal, Sebastian Grunt, Sandeep Kamal, Juan Antonio Delgado Rodríguez, Mária Regényi, Roland Wiest, Christian Weisstanner, Claus Kiefer, Maja Steinlin, Regula Everts
Background: The aim of this study was to compare the relationship between core executive functions and frontoparietal network connections at rest between children who had suffered an arterial ischemic stroke and typically developing peers. Methods: Children diagnosed with arterial ischemic stroke more than two years previously and typically developing controls were included. Executive function (EF) measures comprised inhibition (Go-NoGo task), fluency (category fluency task), processing speed (processing speed tasks), divided attention, working memory (letter-number sequencing), conceptual reasoning (matrices) and EF in everyday life (questionnaire)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29116870/inhibitory-control-and-impulsivity-levels-in-women-crack-users
#4
Adriana Raquel Binsfeld Hess, Carolina B Menezes, Rosa Maria Martins de Almeida
OBJECTIVE: investigate impulsivity levels and inhibitory control in women crack users and explore the relationships between impulsivity and inhibitory control. METHOD AND DESIGN: 52 healthy women (M = 32.83 years; SD = 9.54) and 46 crack cocaine users (M = 31.02 years; SD = 7.73), in abstinence, performed the assessment protocol included a Sociodemographic Data Questionnaire, Mini-Mental State Examination (MMSE), a GO/No-Go Task and the Barratt Impulsiveness Scale-11 (BIS-11)...
November 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29058484/neurite-outgrowth-inhibitor-b-receptor-a-versatile-receptor-with-multiple-functions-and-actions
#5
Shuang-Lian Long, Yu-Kun Li, Yuan-Jie Xie, Zhi-Feng Long, Jin-Feng Shi, Zhong-Cheng Mo
Members of the reticulon protein family are predominantly distributed within the endoplasmic reticulum. The neurite outgrowth inhibitor (Nogo) has three subtypes, including Nogo-A (200 kDa), Nogo-B (55 kDa), and Nogo-C (25 kDa). Nogo-A and Nogo-C are potent Nogos that are predominantly expressed in the central nervous system. Nogo-B, the splice variant of reticulon-4, is expressed widely in multiple human organ systems, including the liver, lung, kidney, blood vessels, and inflammatory cells. Moreover, the Nogo-B receptor (NgBR) can interact with Nogo-B and can independently affect nervous system regeneration, the chemotaxis of endothelial cells, proliferation, and apoptosis...
October 23, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29050340/nogo-b-promotes-emt-in-lung-fibrosis-via-mmp14-mediates-free-tgf-beta1-formation
#6
Ye Xiong, Jing Zhang, Lingzhi Shi, Yunye Ning, Ying Zhu, Si Chen, Meng Yang, Jingyu Chen, Guo-Wu Zhou, Qiang Li
Idiopathic pulmonary fibrosis (IPF) is a lung disease with an extremely poor prognosis. Epithelial mesenchymal transition (EMT) appearing on the airway epithelial cell plays an essential role in the formation and development of Idiopathic pulmonary fibrosis. In this paper, Bleomycin (BLM)-induced mice model combined with bioinformatics analysis were employed to elucidate the potential mechanism of EMT in pulmonary fibrosis. The obtained results showed that endoplasmic reticulum protein Nogo-b may promote MMP14-mediated proprotein maturation of TGF-β1, accelerating the release of free TGF-β1 in type II airway epithelial cells A549, subsquently, induce the epithelial-mesenchymal transition (EMT) of the cell...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049996/nogo-b-promotes-angiogenesis-in-proliferative-diabetic-retinopathy-via-vegf-pi3k-akt-pathway-in-an-autocrine-manner
#7
Yuelu Zhang, Liang Wang, Yuechan Zhang, Mo Wang, Qinglei Sun, Fangzhou Xia, Ruobing Wang, Lin Liu
BACKGROUND/AIMS: Nogo-B, a conservative protein of endoplasmic reticulum, is a member of the reticulon family of proteins. Proliferative diabetic retinopathy (PDR) is the major concerning problem of diabetic retinopathy. This study explored the role of Nogo-B in the regulation of angiogenesis in PDR patients and primary human retinal endothelial cells (HRMECs). METHODS: Nogo-B was down-regulated through the use of Lentivirus-NogoB-RNAi, the effects of Nogo-B on angiogenesis under high glucose stimulation were evaluated via CCK-8 assay, wound closure assay, transwell assay, and tube formation assay...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29027701/cellular-and-molecular-characterization-of-idh1-mutated-diffuse-low-grade-gliomas-reveals-tumor-heterogeneity-and-absence-of-egfr-pdgfr%C3%AE-activation
#8
S Azar, N Leventoux, C Ripoll, V Rigau, C Gozé, F Lorcy, L Bauchet, H Duffau, P O Guichet, B Rothhut, J P Hugnot
Diffuse low grade gliomas (DLGG, grade II gliomas) are slowly-growing brain tumors that often progress into high grade gliomas. Most tumors have a missense mutation for IDH1 combined with 1p19q codeletion in oligodendrogliomas or ATRX/TP53 mutations in astrocytomas. The phenotype of tumoral cells, their environment and the pathways activated in these tumors are still ill-defined and are mainly based on genomics and transcriptomics analysis. Here we used freshly-resected tumors to accurately characterize the tumoral cell population and their environment...
October 13, 2017: Glia
https://www.readbyqxmd.com/read/28964752/inhibition-of-nkcc1-promotes-axonal-growth-and-motor-recovery-in-ischemic-rats
#9
X P Mu, H B Wang, X Cheng, L Yang, X Y Sun, H L Qu, S S Zhao, Z K Zhou, T T Liu, T Xiao, B Song, J Jolkkonen, C S Zhao
Bumetanide is a selective inhibitor of the Na(+)-K(+)-Cl(-)-co-transporter 1(NKCC1). We studied whether bumetanide could affect axonal growth and behavioral outcome in stroke rats. Adult male Wistar rats were randomly assigned to four groups: sham-operated rats treated with vehicle or bumetanide, and ischemic rats treated with vehicle or bumetanide. Endothelin-1 was used to induce focal cerebral ischemia. Bumetanide administration (i.c.v.) started on postoperative day 7 and continued for 3 weeks. Biotinylated dextran amine (BDA) was injected into the right imotor cortex on postoperative day 14 to trace corticospinal tract (CST) fibers sprouting into the denervated cervical spinal cord...
December 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28818144/refining-selection-for-elite-troops-by-predicting-military-training-outcome
#10
Susan Vrijkotte, Romain Meeusen, Bart Roelands, Sabine Kubesch, Olivier Mairesse, Guy de Schutter, Nathalie Pattyn
INTRODUCTION: Paratrooper training courses are very demanding, leading to a high number of drop-outs, despite existing selection criteria. This study investigated physiological, neuropsychological, and subjective data of completers and drop-outs during paratrooper training to identify potential predictive indices. METHODS: Tested were 24 paratrooper soldiers before (t0), after 8 wk (t1), and at the end of a 12-wk training camp (t2). There were 11 soldiers who completed the course and 13 dropped out...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28766262/response-requirements-affect-offside-judgments-in-football-soccer
#11
Frowin Fasold, Peter Wühr, Daniel Memmert
Judging offside in football represents a typical go-nogo task (offside-raising the flag, no offside-no response). Nevertheless, several studies involved two-choice tasks (e.g. offside-press key A, no offside-press key B) to investigate potential sources of errors in offside situations. While go-nogo and choice-response tasks are commonly used in experimental psychology, response preferences may differ between the two tasks. Therefore, we investigated the impact of response requirements on offside judgments in a sample of male participants without experience in professional refereeing...
August 1, 2017: Psychological Research
https://www.readbyqxmd.com/read/28718301/web-addiction-in-the-brain-cortical-oscillations-autonomic-activity-and-behavioral-measures
#12
Michela Balconi, Salvatore Campanella, Roberta Finocchiaro
Background and aims Internet addiction (IA) was recently defined as a disorder tagging both the impulse control and the reward systems. Specifically, inhibitory deficits and reward bias were considered highly relevant in IA. This research aims to examine the electrophysiological correlates and autonomic activity [skin conductance response (SCR) and heart rate] in two groups of young subjects (N = 25), with high or low IA profile [tested by the Internet Addiction Test (IAT)], with specific reference to gambling behavior...
July 18, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28701884/cis-prenyltransferase-interacts-with-a-nogo-b-receptor-homolog-for-dolichol-biosynthesis-in-panax-ginseng-meyer
#13
Ngoc Quy Nguyen, Sang-Choon Lee, Tae-Jin Yang, Ok Ran Lee
BACKGROUND: Prenyltransferases catalyze the sequential addition of isopentenyl diphosphate units to allylic prenyl diphosphate acceptors and are classified as either trans-prenyltransferases (TPTs) or cis-prenyltransferases (CPTs). The functions of CPTs have been well characterized in bacteria, yeast, and mammals compared to plants. The characterization of CPTs also has been less studied than TPTs. In the present study, molecular cloning and functional characterization of a CPT from a medicinal plant, Panax ginseng Mayer were addressed...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28664706/neuromarkers-of-post-traumatic-stress-disorder-ptsd-in-a-patient-after-bilateral-hand-amputation-erp-case-study
#14
Anna Chrapusta, Juri D Kropotov, Maria Pąchalska
<b>Introduction</b>. There is a lack in the worldwide literature of reports on the Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in patients after bilateral hand amputation The aim of this study was to test a hypothesis regarding developing Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation with the use of Event Related Potentials (ERPs). On the basis of previous research, the amplitudes of P3 ERP components elicited in the cued GO/NOGO tasks have been chosen as candidates for neuromarkers of PTSD...
June 8, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28654838/callous-unemotional-traits-moderate-executive-function-in-children-with-asd-and-adhd-a-pilot-event-related-potential-study
#15
C Tye, R Bedford, P Asherson, K L Ashwood, B Azadi, P Bolton, G McLoughlin
Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are associated with varied executive function (EF) difficulties. Callous-unemotional (CU) traits, a proposed antecedent of adult psychopathy, are often associated with intact or enhanced EF. Here we test whether CU traits may therefore modulate EF in ASD and ADHD, in which EF is typically impaired. We collected CU traits and measured event-related potentials (ERPs) that index EF during a cued-continuous performance test (CPT-OX) in boys with ASD, ADHD, comorbid ASD+ADHD and typical controls...
August 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28628795/knockout-of-the-nogo-b-gene-attenuates-tumor-growth-and-metastasis-in-hepatocellular-carcinoma
#16
Bo Zhu, Shaobo Chen, Xiaoding Hu, Xiaofeng Jin, Yichen Le, Lihuan Cao, Zhonghua Yuan, Zhen Lin, Songmin Jiang, Lichun Sun, Long Yu
Human hepatocellular carcinoma (HCC) is a malignant cancer. It is a challenge to develop anti-HCC drugs due to HCC's extreme aggressiveness and with the sensitivity of the liver to show severe adverse effects. More importantly, the precise mechanisms causing HCC pathogenicity are not known. Our previous study disclosed Nogo-B as a reticulon 4 (Rtn4) family member. In the present study, we first identified that Nogo-B played a critical role in HCC progression. We found, via in vitro and in vivo assays, that Nogo-B was expressed aberrantly in primary HCC tumor tissues and immortal HCC cells but was relatively scarce in the normal liver tissues or cells...
July 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28605663/patients-with-bulimia-nervosa-do-not-show-typical-neurodevelopment-of-cognitive-control-under-emotional-influences
#17
Michael F W Dreyfuss, Melissa L Riegel, Gloria A Pedersen, Alexandra O Cohen, Melanie R Silverman, Jonathan P Dyke, Laurel E S Mayer, B Timothy Walsh, B J Casey, Allegra I Broft
Bulimia nervosa (BN) emerges in the late teen years and is characterized by binge eating and related compensatory behaviors. These behaviors often co-occur with periods of negative affect suggesting an association between emotions and control over eating behavior. In the current study, we examined how cognitive control and neural processes change under emotional states of arousal in 46 participants with (n=19) and without (n=27) BN from the ages of 18-33 years. Participants performed a go/nogo task consisting of brief negative, positive and neutral emotional cues and sustained negative, positive and neutral emotional states of arousal during functional magnetic resonance imaging (fMRI)...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28602162/endothelial-mir-26a-regulates-vegf-nogo-b-receptor-mediated-angiogenesis
#18
Ha-Neul Jo, Hyesoo Kang, Aram Lee, Jihea Choi, Woochul Chang, Myeong-Sok Lee, Jongmin Kim
The Nogo-B receptor (NgBR) is necessary for not only Nogo-B-mediated angiogenesis but also vascular endothelial growth factor (VEGF) -induced angiogenesis. However, the molecular mechanisms underlying the regulatory role of the VEGF-NgBR axis in angiogenesis are not fully understood. Here, we report that miR-26a serves as a critical regulator of VEGF-mediated angiogenesis through directly targeting NgBR in endothelial cells (ECs). Stimulation of ECs by VEGF increased the expression of NgBR and decreased the expression of miR-26a...
July 2017: BMB Reports
https://www.readbyqxmd.com/read/28598112/-effects-of-fluoxetine-on-nogo-expression-and-collagen-production-with-decrease-of-pulmonary-artery
#19
Xun Ran, Jian-Xun Zhao, Hu Nie, Yu-Cheng Chen
OBJECTIVES: To investigate the effect of fluoxetine on neurite growth inhibitor (Nogo) expession and collagen production of cardiac tissue in rats with right heart failure and pulmonary hypertension. METHODS: Thirty one male SD rats were randomly divided into the treatment group,right heart failure group and normal control group.The rats in the treatment group and right heart failure group received intrapertioneal injection of monocrotaline (MCT,60 mg/kg) to induce pulmonary hypertension and right heart failure...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28571719/blockade-of-chondroitin-sulfate-proteoglycans-induced-axonal-growth-inhibition-by-lotus
#20
Yuji Kurihara, Yu Saito, Kohtaro Takei
Chondroitin sulfate proteoglycans (CSPGs) are axon growth inhibitors in the glial scar, and restrict axon regeneration following damage to the adult mammalian central nervous system. CSPGs have recently been identified as functional ligands for Nogo receptor-1 (NgR1), which is the common receptor for Nogo proteins, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and B lymphocyte stimulator (BLyS). We have previously reported that through its binding to NgR1, lateral olfactory tract usher substance (LOTUS) suppresses Nogo, MAG, OMgp, and BLyS-induced axon growth inhibition...
May 30, 2017: Neuroscience
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