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https://www.readbyqxmd.com/read/28222346/inhibitory-control-in-euthymic-bipolar-disorder-event-related-potentials-during-a-go-nogo-task
#1
A M Morsel, M Dhar, W Hulstijn, A Temmerman, M Morrens, B Sabbe
OBJECTIVES: Patients with bipolar disorder (BD) are reported to have difficulties with inhibition, even in a euthymic state. However, the literature on cortical activity associated with response inhibition in BD remains ambiguous. This study investigates inhibition in euthymic BD using electrophysiological measures, while controlling for effects of specific medications. METHODS: Twenty patients with BD were compared with eighteen healthy controls on a Go/NoGo task while electroencephalogram was recorded...
April 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28214833/nogo-b-facilitates-lps-mediated-immune-responses-by-up-regulation-of-tlr4-signaling-in-macrophage-raw264-7
#2
Ying Zhu, Qiang Tong, Jia Ye, Yunye Ning, Ye Xiong, Meng Yang, Hua Xiao, Jian Lu, Wujian Xu, Jiandong Li, Qiang Li
BACKGROUND/AIMS: Nogo-B, a member of the reticulon family of proteins, is mainly located in the endoplasmic reticulum (ER). Here, we investigate the function and mechanism of Nogo-B in the regulation of TLR4-associated immune responses in the macrophage cell line of RAW264.7. METHODS: Nogo-B was up- and down-regulated through the use of appropriate adenoviral vectors or siRNA, and the effects of Nogo-B on macrophages under liposaccharide (LPS) stimulation were evaluated via western blotting, immunofluorescence, enzyme-linked immunosorbent assay (ELISA), flow cytometric analysis, and transwell assay...
January 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28090670/an-endoplasmic-reticulum-protein-nogo-b-facilitates-alcoholic-liver-disease-through-regulation-of-kupffer-cell-polarization
#3
Jin-Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri
Background Nogo-B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Since ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). Methods M1 and M2 phenotypes were assessed in relation to Nogo-B expression and disease severity in liver specimens from ALD patients (NCT01875211). Liver specimens from wild-type (WT) and Nogo-B knockout (KO) mice fed control or Lieber-DeCarli ethanol liquid diet (5% ethanol) for 6 weeks were analyzed for liver injury and steatosis...
January 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28087369/multidimensional-assessment-of-impulsivity-in-relation-to-obesity-and-food-addiction
#4
Lauren VanderBroek-Stice, Monika K Stojek, Steven R H Beach, Michelle R vanDellen, James MacKillop
Based on similarities between overconsumption of food and addictive drugs, there is increasing interest in "food addiction," a compulsive eating pattern defined using symptoms parallel to substance use disorders. Impulsivity, a multidimensional construct robustly linked to drug addiction, has been increasingly examined as an obesity determinant, but with mixed findings. This study sought to clarify relations between three major domains of impulsivity (i.e., impulsive personality traits, discounting of delayed rewards, and behavioral inhibition) in both obesity and food addiction...
May 1, 2017: Appetite
https://www.readbyqxmd.com/read/28068323/the-nogo-b-receptor-promotes-ras-plasma-membrane-localization-and-activation
#5
B Zhao, W Hu, S Kumar, P Gonyo, U Rana, Z Liu, B Wang, W Q Duong, Z Yang, C L Williams, Q R Miao
The localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice...
January 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28065167/diagnostic-utility-of-brain-activity-flow-patterns-analysis-in-attention-deficit-hyperactivity-disorder
#6
J Biederman, P Hammerness, B Sadeh, Z Peremen, A Amit, H Or-Ly, Y Stern, A Reches, A Geva, S V Faraone
BACKGROUND: A previous small study suggested that Brain Network Activation (BNA), a novel ERP-based brain network analysis, may have diagnostic utility in attention deficit hyperactivity disorder (ADHD). In this study we examined the diagnostic capability of a new advanced version of the BNA methodology on a larger population of adults with and without ADHD. METHOD: Subjects were unmedicated right-handed 18- to 55-year-old adults of both sexes with and without a DSM-IV diagnosis of ADHD...
January 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28040019/relative-salience-of-spectral-and-temporal-features-in-auditory-long-term-memory
#7
Pingbo Yin, Shihab A Shamma, Jonathan B Fritz
In order to explore the representation of sound features in auditory long-term memory, two groups of ferrets were trained on Go vs Nogo, 3-zone classification tasks. The sound stimuli differed primarily along the spectral and temporal dimensions. In Group 1, two ferrets were trained to (i) classify tones based on their frequency (Tone-task), and subsequently learned to (ii) classify white noise based on its amplitude modulation rate (AM-task). In Group 2, two ferrets were trained to classify tones based on correlated combinations of their frequency and AM rate (AM-Tone task)...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27786289/nogo-a-rtn4a-and-nogo-b-rtn4b-are-simultaneously-expressed-in-epithelial-fibroblast-and-neuronal-cells-and-maintain-er-morphology
#8
Olli Rämö, Darshan Kumar, Erika Gucciardo, Merja Joensuu, Maiju Saarekas, Helena Vihinen, Ilya Belevich, Olli-Pekka Smolander, Kui Qian, Petri Auvinen, Eija Jokitalo
Reticulons (RTNs) are a large family of membrane associated proteins with various functions. NOGO-A/RTN4A has a well-known function in limiting neurite outgrowth and restricting the plasticity of the mammalian central nervous system. On the other hand, Reticulon 4 proteins were shown to be involved in forming and maintaining endoplasmic reticulum (ER) tubules. Using comparative transcriptome analysis and qPCR, we show here that NOGO-B/RTN4B and NOGO-A/RTN4A are simultaneously expressed in cultured epithelial, fibroblast and neuronal cells...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27714404/the-influence-of-motor-imagery-on-the-learning-of-a-fine-hand-motor-skill
#9
Jagna Sobierajewicz, Anna Przekoracka-Krawczyk, Wojciech Jaśkowski, Willem B Verwey, Rob van der Lubbe
Motor imagery has been argued to affect the acquisition of motor skills. The present study examined the specificity of motor imagery on the learning of a fine hand motor skill by employing a modified discrete sequence production task: the Go/NoGo DSP task. After an informative cue, a response sequence had either to be executed, imagined, or withheld. To establish learning effects, the experiment was divided into a practice phase and a test phase. In the latter phase, we compared mean response times and accuracy during the execution of unfamiliar sequences, familiar imagined sequences, and familiar executed sequences...
October 6, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27595798/-oligodendroglioma-with-neuronal-differentiation-in-an-8-month-old-african-hedgehog-atelerix-albiventris
#10
Iris Völker, Iris Schwarze, Tina E Brezina, Saskia Köstlinger, Marion Hewicker-Trautwein
An 8-month-old, male African hedgehog clinically displayed a wobbly walk, anuria, inappetence and apathy, whereupon the suspected diagnosis wobbly hedgehog syndrome was made. After exacerbation, the hedgehog was euthanized. Histologically, a tumour mainly consisting of medium-sized, oval tumour cells and a smaller number of spindeloid cells was found in the cerebrum. The tumour contained neuropil islets and extracellular myxoid material. Immunohistochemically, the tumour cells expressed oligodendroglial (neurite outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) and neuronal (neuron-specific enolase, NSE; microtubule-associated protein-2a, MAP-2a; synaptophysin) cell markers...
October 12, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27562337/sphingolipid-de-novo-biosynthesis-a-rheostat-of-cardiovascular-homeostasis
#11
REVIEW
Linda Sasset, Yi Zhang, Teresa M Dunn, Annarita Di Lorenzo
Sphingolipids (SL) are both fundamental structural components of the eukaryotic membranes and signaling molecules that regulate a variety of biological functions. The highly-bioactive lipids, ceramide and sphingosine-1-phosphate, have emerged as important regulators of cardiovascular function in health and disease. In this review we discuss recent insights into the role of SLs, particularly ceramide and sphingosine-1-phosphate, in the pathophysiology of the cardiovascular system. We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme of de novo SL biosynthesis, with an emphasis on the recently discovered inhibitors of serine palmitoyltransferase, ORMDL and NOGO-B proteins...
November 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27498891/delayed-n2-response-in-go-condition-in-a-visual-go-nogo-erp-study-in-children-who-stutter
#12
Johanna Piispala, Mika Kallio, Risto Bloigu, Eira Jansson-Verkasalo
PURPOSE OF THE STUDY: The main aim of the study was to investigate the attentional and inhibitory abilities and their underlying processes of children who stutter by using behavioural measurement and event-related potentials (ERP) in a visual Go/Nogo paradigm. METHODS: Participants were 11 children who stutter (CWS; mean age 8.1, age range 6.3-9.5 years) and 19 typically developed children (TDC; mean age 8.1, age range 5.8-9.6 years). They performed a visual Go/Nogo task with simultaneous EEG recording to obtain ERP responses...
June 2016: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/27465397/mark2-rescues-nogo-66-induced-inhibition-of-neurite-outgrowth-via-regulating-microtubule-associated-proteins-in-neurons-in-vitro
#13
Yu-Chao Zuo, Nan-Xiang Xiong, Jian-Ying Shen, Hua Yu, Yi-Zhi Huang, Hong-Yang Zhao
The ability of neurons in the adult mammalian central nervous system (CNS) to regenerate after injury is limited by inhibitors in CNS myelin. Nogo-66 is the most important myelin inhibitor but the mechanisms of Nogo-66 inhibition of neurite outgrowth remain poorly understood. Particularly, the relationship between Nogo-66 and microtubule-affinity regulating kinase 2 (MARK2) has not been examined. This study investigated the role of MARK2 in Nogo-66 inhibition and the function of MARK2 in neurite elongation in neurons in vitro...
November 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27445212/changes-in-cortico-subcortical-and-subcortico-subcortical-connectivity-impact-cognitive-control-to-emotional-cues-across-development
#14
Aaron S Heller, Alexandra O Cohen, Michael F W Dreyfuss, B J Casey
The capacity to suppress inappropriate thoughts, emotions and actions in favor of appropriate ones shows marked changes throughout childhood and adolescence. Most research has focused on pre-frontal circuit development to explain these changes. Yet, subcortical circuitry involving the amygdala and ventral striatum (VS) has been shown to modulate cue-triggered motivated behaviors in rodents. The nature of the interaction between these two subcortical regions in humans is less well understood, especially during development when there appears to be heightened sensitivity to emotional cues...
December 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27354599/prognostic-significance-of-nogo-a-b-and-nogo-b-receptor-expression-in-malignant-melanoma-a-preliminary-study
#15
Jacek Calik, Bartosz Pula, Aleksandra Piotrowska, Andrzej Wojnar, Wojciech Witkiewicz, Jedrzej Grzegrzolka, Marzena Podhorska-Okolow, Piotr Dziegiel
BACKGROUND: Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis. MATERIALS AND METHODS: Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM). RESULTS: Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27241709/lorcaserin-and-cp-809101-reduce-motor-impulsivity-and-reinstatement-of-food-seeking-behavior-in-male-rats-implications-for-understanding-the-anti-obesity-property-of-5-ht2c-receptor-agonists
#16
Guy A Higgins, Leo B Silenieks, Everett B Altherr, Cam MacMillan, Paul J Fletcher, Wayne E Pratt
RATIONALE: The 5-HT2C receptor agonist lorcaserin (Belviq®) has been approved by the FDA for the treatment of obesity. Impulsivity is a contributory feature of some eating disorders. OBJECTIVE: Experiments investigated the effect of lorcaserin and the highly selective 5-HT2C agonist CP-809101 on measures of impulsivity and on reinstatement of food-seeking behaviour, a model of dietary relapse. The effect of both drugs on 22-h deprivation-induced feeding was also examined, as was the effect of prefeeding in each impulsivity test...
July 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27187236/effects-of-acute-aerobic-exercise-on-neural-correlates-of-attention-and-inhibition-in-adolescents-with-bipolar-disorder
#17
A W S Metcalfe, B J MacIntosh, A Scavone, X Ou, D Korczak, B I Goldstein
Executive dysfunction is common during and between mood episodes in bipolar disorder (BD), causing social and functional impairment. This study investigated the effect of acute exercise on adolescents with BD and healthy control subjects (HC) to test for positive or negative consequences on neural response during an executive task. Fifty adolescents (mean age 16.54±1.47 years, 56% female, 30 with BD) completed an attention and response inhibition task before and after 20 min of recumbent cycling at ~70% of age-predicted maximum heart rate...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27180168/enhanced-attention-and-impulsive-action-following-nmda-receptor-glun2b-selective-antagonist-pretreatment
#18
Guy A Higgins, Leo B Silenieks, Cam MacMillan, Julia Sevo, Fiona D Zeeb, Sandy Thevarkunnel
NMDA GluN2B (NR2B) subtype selective antagonists are currently in clinical development for a variety of indications, including major depression. We previously reported the selective NMDA GluN2B antagonists Ro 63-1908 and traxoprodil, increase premature responding in a 5-choice serial reaction time task (5-CSRTT) suggesting an effect on impulsive action. The present studies extend these investigations to a Go-NoGo and delay discounting task, and the 5-CSRTT under test conditions of both regular (5s) and short (2-5s) multiple ITI (Intertrial interval)...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27168778/transplantation-of-mesenchymal-stem-cells-promotes-the-functional-recovery-of-the-central-nervous-system-following-cerebral-ischemia-by-inhibiting-myelin-associated-inhibitor-expression-and-neural-apoptosis
#19
Nianping Feng, Guang Hao, Fenggang Yang, Fujun Qu, Haihong Zheng, Songlan Liang, Yonghua Jin
Cerebral ischemia, which may lead to cerebral hypoxia and damage of the brain tissue, is a leading cause of human mortality and adult disability. Mesenchymal stem cells (MSCs) are a class of adult progenitor cells with the ability to differentiate into multiple cell types. The transplantation of bone marrow-derived MSCs is a potential therapeutic strategy for cerebral ischemia. However, the underlying mechanism has yet to be elucidated. In the present study, primary MSCs were isolated from healthy rats, labeled and transplanted into the brains of middle cerebral artery occlusion rat models...
May 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27158676/endothelial-nogo-b-regulates-sphingolipid-biosynthesis-to-promote-pathological-cardiac-hypertrophy-during-chronic-pressure-overload
#20
Yi Zhang, Yan Huang, Anna Cantalupo, Paula S Azevedo, Mauro Siragusa, Jacek Bielawski, Frank J Giordano, Annarita Di Lorenzo
We recently discovered that endothelial Nogo-B, a membrane protein of the ER, regulates vascular function by inhibiting the rate-limiting enzyme, serine palmitoyltransferase (SPT), in de novo sphingolipid biosynthesis. Here, we show that endothelium-derived sphingolipids, particularly sphingosine-1-phosphate (S1P), protect the heart from inflammation, fibrosis, and dysfunction following pressure overload and that Nogo-B regulates this paracrine process. SPT activity is upregulated in banded hearts in vivo as well as in TNF-α-activated endothelium in vitro, and loss of Nogo removes the brake on SPT, increasing local S1P production...
April 21, 2016: JCI Insight
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