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https://www.readbyqxmd.com/read/28628795/knockout-of-the-nogo-b-gene-attenuates-tumor-growth-and-metastasis-in-hepatocellular-carcinoma
#1
Bo Zhu, Shaobo Chen, Xiaoding Hu, Xiaofeng Jin, Yichen Le, Lihuan Cao, Zhonghua Yuan, Zhen Lin, Songmin Jiang, Lichun Sun, Long Yu
Human hepatocellular carcinoma (HCC) is a malignant cancer. It is a challenge to develop anti-HCC drugs due to HCC's extreme aggressiveness and with the sensitivity of the liver to show severe adverse effects. More importantly, the precise mechanisms causing HCC pathogenicity are not known. Our previous study disclosed Nogo-B as a reticulon 4 (Rtn4) family member. In the present study, we first identified that Nogo-B played a critical role in HCC progression. We found, via in vitro and in vivo assays, that Nogo-B was expressed aberrantly in primary HCC tumor tissues and immortal HCC cells but was relatively scarce in the normal liver tissues or cells...
June 16, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28605663/patients-with-bulimia-nervosa-do-not-show-typical-neurodevelopment-of-cognitive-control-under-emotional-influences
#2
Michael F W Dreyfuss, Melissa L Riegel, Gloria A Pedersen, Alexandra O Cohen, Melanie R Silverman, Jonathan P Dyke, Laurel E S Mayer, B Timothy Walsh, B J Casey, Allegra I Broft
Bulimia nervosa (BN) emerges in the late teen years and is characterized by binge eating and related compensatory behaviors. These behaviors often co-occur with periods of negative affect suggesting an association between emotions and control over eating behavior. In the current study, we examined how cognitive control and neural processes change under emotional states of arousal in 46 participants with (n=19) and without (n=27) BN from the ages of 18-33 years. Participants performed a go/nogo task consisting of brief negative, positive and neutral emotional cues and sustained negative, positive and neutral emotional states of arousal during functional magnetic resonance imaging (fMRI)...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28602162/endothelial-mir-26a-regulates-vegf-nogo-b-receptor-mediated-angiogenesis
#3
Ha-Neul Jo, Hyesoo Kang, Aram Lee, Jihea Choi, Woochul Chang, Myeong-Sok Lee, Jongmin Kim
The Nogo-B receptor (NgBR) is necessary for not only Nogo-B-mediated angiogenesis but also vascular endothelial growth factor (VEGF)-induced angiogenesis. However, the molecular mechanisms underlying the regulatory role of the VEGF-NgBR axis in angiogenesis are not fully understood. Here, we report that miR-26a serves as a critical regulator of VEGF-mediated angiogenesis through directly targeting NgBR in endothelial cells (ECs). Stimulation of ECs by VEGF increased the expression of NgBR and decreased the expression of miR-26a...
June 12, 2017: BMB Reports
https://www.readbyqxmd.com/read/28598112/-effects-of-fluoxetine-on-nogo-expression-and-collagen-production-with-decrease-of-pulmonary-artery
#4
Xun Ran, Jian-Xun Zhao, Hu Nie, Yu-Cheng Chen
OBJECTIVES: To investigate the effect of fluoxetine on neurite growth inhibitor (Nogo) expession and collagen production of cardiac tissue in rats with right heart failure and pulmonary hypertension. METHODS: Thirty one male SD rats were randomly divided into the treatment group,right heart failure group and normal control group.The rats in the treatment group and right heart failure group received intrapertioneal injection of monocrotaline (MCT,60 mg/kg) to induce pulmonary hypertension and right heart failure...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28571719/blockade-of-chondroitin-sulfate-proteoglycans-induced-axonal-growth-inhibition-by-lotus
#5
Yuji Kurihara, Yu Saito, Kohtaro Takei
Chondroitin sulfate proteoglycans (CSPGs) are axon growth inhibitors in the glial scar, and restrict axon regeneration following damage to the adult mammalian central nervous system. CSPGs have recently been identified as functional ligands for Nogo receptor-1 (NgR1), which is the common receptor for Nogo proteins, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and B lymphocyte stimulator (BLyS). We have previously reported that through its binding to NgR1, lateral olfactory tract usher substance (LOTUS) suppresses Nogo, MAG, OMgp, and BLyS-induced axon growth inhibition...
May 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28543060/nogo-b-is-the-major-form-of-nogo-at-the-floor-plate-and-likely-mediates-crossing-of-commissural-axons-in-the-mouse-spinal-cord
#6
Liqing Wang, Chao Yu, Jun Wang, Peggy Leung, Ding Ma, Hui Zhao, Jeremy S H Taylor, Sun-On Chan
Using Nogo antibodies with defined binding specificity, Nogo-B, but not Nogo-A, was localized on radial glia in the floor plate of mouse embryos. The presence of Nogo-B was confirmed in Nogo-A knockout mice. In explant cultures of embryonic day (E) 11 and E12 spinal cord, blocking of NgR function with antagonist peptide NEP1-40 reduced the crossing of newly arrived commissural axons, resulting in an accumulation of growth cones in the floor plate. Analysis of growth cone morphology demonstrated an increase in size of growth cones in the floor plate after peptide treatment, which was not detected in axons growing towards the midline...
May 22, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28521364/chemotherapy-and-post-traumatic-stress-in-the-causation-of-cognitive-dysfunction-in-breast-cancer-patients
#7
Kerstin Hermelink, Markus Bühner, Philipp Sckopke, Franziska Neufeld, Judith Kaste, Varinka Voigt, Karin Münzel, Rachel Wuerstlein, Nina Ditsch, Karin Hellerhoff, Dorothea Rjosk-Dendorfer, Michael Braun, Franz Edler von Koch, Kristin Härtl, Stephan Hasmüller, Ingo Bauerfeind, Gerlinde Debus, Peter Herschbach, Sven Mahner, Nadia Harbeck
Background: Cancer-related cognitive dysfunction has mostly been attributed to chemotherapy; this explanation, however, fails to account for cognitive dysfunction observed in chemotherapy-naïve patients. In a controlled, longitudinal, multisite study, we tested the hypothesis that cognitive function in breast cancer patients is affected by cancer-related post-traumatic stress. Methods: Newly diagnosed breast cancer patients and healthy control subjects, age 65 or younger, underwent three assessments within one year, including paper-and-pencil and computerized neuropsychological tests, clinical diagnostics of post-traumatic stress disorder (PTSD), and self-reported cognitive function...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28222346/inhibitory-control-in-euthymic-bipolar-disorder-event-related-potentials-during-a-go-nogo-task
#8
A M Morsel, M Dhar, W Hulstijn, A Temmerman, M Morrens, B Sabbe
OBJECTIVES: Patients with bipolar disorder (BD) are reported to have difficulties with inhibition, even in a euthymic state. However, the literature on cortical activity associated with response inhibition in BD remains ambiguous. This study investigates inhibition in euthymic BD using electrophysiological measures, while controlling for effects of specific medications. METHODS: Twenty patients with BD were compared with eighteen healthy controls on a Go/NoGo task while electroencephalogram was recorded...
April 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28214833/nogo-b-facilitates-lps-mediated-immune-responses-by-up-regulation-of-tlr4-signaling-in-macrophage-raw264-7
#9
Ying Zhu, Qiang Tong, Jia Ye, Yunye Ning, Ye Xiong, Meng Yang, Hua Xiao, Jian Lu, Wujian Xu, Jiandong Li, Qiang Li
BACKGROUND/AIMS: Nogo-B, a member of the reticulon family of proteins, is mainly located in the endoplasmic reticulum (ER). Here, we investigate the function and mechanism of Nogo-B in the regulation of TLR4-associated immune responses in the macrophage cell line of RAW264.7. METHODS: Nogo-B was up- and down-regulated through the use of appropriate adenoviral vectors or siRNA, and the effects of Nogo-B on macrophages under liposaccharide (LPS) stimulation were evaluated via western blotting, immunofluorescence, enzyme-linked immunosorbent assay (ELISA), flow cytometric analysis, and transwell assay...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28090670/an-endoplasmic-reticulum-protein-nogo-b-facilitates-alcoholic-liver-disease-through-regulation-of-kupffer-cell-polarization
#10
Jin-Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri
Nogo-B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Because ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). M1 and M2 phenotypes were assessed in relation to Nogo-B expression and disease severity in liver specimens from ALD patients (NCT01875211). Liver specimens from wild-type (WT) and Nogo-B knockout (KO) mice fed a control or Lieber-DeCarli ethanol liquid diet (5% ethanol) for 6 weeks were analyzed for liver injury and steatosis...
May 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28087369/multidimensional-assessment-of-impulsivity-in-relation-to-obesity-and-food-addiction
#11
Lauren VanderBroek-Stice, Monika K Stojek, Steven R H Beach, Michelle R vanDellen, James MacKillop
Based on similarities between overconsumption of food and addictive drugs, there is increasing interest in "food addiction," a compulsive eating pattern defined using symptoms parallel to substance use disorders. Impulsivity, a multidimensional construct robustly linked to drug addiction, has been increasingly examined as an obesity determinant, but with mixed findings. This study sought to clarify relations between three major domains of impulsivity (i.e., impulsive personality traits, discounting of delayed rewards, and behavioral inhibition) in both obesity and food addiction...
May 1, 2017: Appetite
https://www.readbyqxmd.com/read/28068323/the-nogo-b-receptor-promotes-ras-plasma-membrane-localization-and-activation
#12
B Zhao, W Hu, S Kumar, P Gonyo, U Rana, Z Liu, B Wang, W Q Duong, Z Yang, C L Williams, Q R Miao
The localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice...
June 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28065167/diagnostic-utility-of-brain-activity-flow-patterns-analysis-in-attention-deficit-hyperactivity-disorder
#13
J Biederman, P Hammerness, B Sadeh, Z Peremen, A Amit, H Or-Ly, Y Stern, A Reches, A Geva, S V Faraone
BACKGROUND: A previous small study suggested that Brain Network Activation (BNA), a novel ERP-based brain network analysis, may have diagnostic utility in attention deficit hyperactivity disorder (ADHD). In this study we examined the diagnostic capability of a new advanced version of the BNA methodology on a larger population of adults with and without ADHD. METHOD: Subjects were unmedicated right-handed 18- to 55-year-old adults of both sexes with and without a DSM-IV diagnosis of ADHD...
January 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28040019/relative-salience-of-spectral-and-temporal-features-in-auditory-long-term-memory
#14
Pingbo Yin, Shihab A Shamma, Jonathan B Fritz
In order to explore the representation of sound features in auditory long-term memory, two groups of ferrets were trained on Go vs Nogo, 3-zone classification tasks. The sound stimuli differed primarily along the spectral and temporal dimensions. In Group 1, two ferrets were trained to (i) classify tones based on their frequency (Tone-task), and subsequently learned to (ii) classify white noise based on its amplitude modulation rate (AM-task). In Group 2, two ferrets were trained to classify tones based on correlated combinations of their frequency and AM rate (AM-Tone task)...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27786289/nogo-a-rtn4a-and-nogo-b-rtn4b-are-simultaneously-expressed-in-epithelial-fibroblast-and-neuronal-cells-and-maintain-er-morphology
#15
Olli Rämö, Darshan Kumar, Erika Gucciardo, Merja Joensuu, Maiju Saarekas, Helena Vihinen, Ilya Belevich, Olli-Pekka Smolander, Kui Qian, Petri Auvinen, Eija Jokitalo
Reticulons (RTNs) are a large family of membrane associated proteins with various functions. NOGO-A/RTN4A has a well-known function in limiting neurite outgrowth and restricting the plasticity of the mammalian central nervous system. On the other hand, Reticulon 4 proteins were shown to be involved in forming and maintaining endoplasmic reticulum (ER) tubules. Using comparative transcriptome analysis and qPCR, we show here that NOGO-B/RTN4B and NOGO-A/RTN4A are simultaneously expressed in cultured epithelial, fibroblast and neuronal cells...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27714404/the-influence-of-motor-imagery-on-the-learning-of-a-fine-hand-motor-skill
#16
Jagna Sobierajewicz, Anna Przekoracka-Krawczyk, Wojciech Jaśkowski, Willem B Verwey, Rob van der Lubbe
Motor imagery has been argued to affect the acquisition of motor skills. The present study examined the specificity of motor imagery on the learning of a fine hand motor skill by employing a modified discrete sequence production task: the Go/NoGo DSP task. After an informative cue, a response sequence had either to be executed, imagined, or withheld. To establish learning effects, the experiment was divided into a practice phase and a test phase. In the latter phase, we compared mean response times and accuracy during the execution of unfamiliar sequences, familiar imagined sequences, and familiar executed sequences...
October 6, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27595798/-oligodendroglioma-with-neuronal-differentiation-in-an-8-month-old-african-hedgehog-atelerix-albiventris
#17
Iris Völker, Iris Schwarze, Tina E Brezina, Saskia Köstlinger, Marion Hewicker-Trautwein
An 8-month-old, male African hedgehog clinically displayed a wobbly walk, anuria, inappetence and apathy, whereupon the suspected diagnosis wobbly hedgehog syndrome was made. After exacerbation, the hedgehog was euthanized. Histologically, a tumour mainly consisting of medium-sized, oval tumour cells and a smaller number of spindeloid cells was found in the cerebrum. The tumour contained neuropil islets and extracellular myxoid material. Immunohistochemically, the tumour cells expressed oligodendroglial (neurite outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) and neuronal (neuron-specific enolase, NSE; microtubule-associated protein-2a, MAP-2a; synaptophysin) cell markers...
October 12, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27562337/sphingolipid-de-novo-biosynthesis-a-rheostat-of-cardiovascular-homeostasis
#18
REVIEW
Linda Sasset, Yi Zhang, Teresa M Dunn, Annarita Di Lorenzo
Sphingolipids (SL) are both fundamental structural components of the eukaryotic membranes and signaling molecules that regulate a variety of biological functions. The highly-bioactive lipids, ceramide and sphingosine-1-phosphate, have emerged as important regulators of cardiovascular function in health and disease. In this review we discuss recent insights into the role of SLs, particularly ceramide and sphingosine-1-phosphate, in the pathophysiology of the cardiovascular system. We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme of de novo SL biosynthesis, with an emphasis on the recently discovered inhibitors of serine palmitoyltransferase, ORMDL and NOGO-B proteins...
November 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27498891/delayed-n2-response-in-go-condition-in-a-visual-go-nogo-erp-study-in-children-who-stutter
#19
Johanna Piispala, Mika Kallio, Risto Bloigu, Eira Jansson-Verkasalo
PURPOSE OF THE STUDY: The main aim of the study was to investigate the attentional and inhibitory abilities and their underlying processes of children who stutter by using behavioural measurement and event-related potentials (ERP) in a visual Go/Nogo paradigm. METHODS: Participants were 11 children who stutter (CWS; mean age 8.1, age range 6.3-9.5 years) and 19 typically developed children (TDC; mean age 8.1, age range 5.8-9.6 years). They performed a visual Go/Nogo task with simultaneous EEG recording to obtain ERP responses...
June 2016: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/27465397/mark2-rescues-nogo-66-induced-inhibition-of-neurite-outgrowth-via-regulating-microtubule-associated-proteins-in-neurons-in-vitro
#20
Yu-Chao Zuo, Nan-Xiang Xiong, Jian-Ying Shen, Hua Yu, Yi-Zhi Huang, Hong-Yang Zhao
The ability of neurons in the adult mammalian central nervous system (CNS) to regenerate after injury is limited by inhibitors in CNS myelin. Nogo-66 is the most important myelin inhibitor but the mechanisms of Nogo-66 inhibition of neurite outgrowth remain poorly understood. Particularly, the relationship between Nogo-66 and microtubule-affinity regulating kinase 2 (MARK2) has not been examined. This study investigated the role of MARK2 in Nogo-66 inhibition and the function of MARK2 in neurite elongation in neurons in vitro...
November 2016: Neurochemical Research
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