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"Extended criteria graft"

Ana K Islam, Richard J Knight, Wesley A Mayer, Adam B Hollander, Samir Patel, Larry D Teeter, Edward A Graviss, Ashish Saharia, Hemangshu Podder, Emad H Asham, A Osama Gaber
Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Methods. A retrospective single-center comparison of DKT and SKT performed between February 2007 and July 2013. Results. Of 516 deceased donor kidney transplants, 29 were DKT and 487 were SKT. Mean follow-up was 43 ± 67 months. DKT recipients were older and more likely than SKT recipients to receive an extended criteria graft (p < 0...
2016: Journal of Transplantation
Vinzent N Spetzler, Nicolas Goldaracena, Juan Echiverri, J Moritz Kaths, Kristine S Louis, Oyedele A Adeyi, Paul M Yip, David R Grant, Nazia Selzner, Markus Selzner
We developed a novel technique of subnormothermic ex vivo liver perfusion (SNEVLP) for the storage of liver grafts before transplantation. To test the safety of SNEVLP for the nonextended criteria grafts (standard grafts), we compared it to a control group with minimal cold static storage (CS) time. Heart-beating pig liver retrieval was performed. Grafts were either stored in cold unmodified University of Wisconsin solution (CS-1), in cold University of Wisconsin solution with ex vivo perfusion additives (CS-2), or preserved with a sequence of 3 hours CS and 3 hours SNEVLP (33°C), followed by orthotopic liver transplantation...
January 2016: Liver Transplantation
Thomas Vogel, Jens G Brockmann, Peter J Friend
PURPOSE OF REVIEW: There is increasing disparity between the supply of acceptable donor organs and the number of potential transplant recipients. The shortage of organs for transplantation demands optimal utilization of a wider spectrum of donor organs, including nonheart-beating and other extended criteria donors. In the case of the liver, a substantial number of organs are discarded because of a risk of primary nonfunction. RECENT FINDINGS: For many years hypothermic preservation has been the universal standard for organ preservation...
April 2010: Current Opinion in Organ Transplantation
P Dutkowski, O de Rougemont, P-A Clavien
Due to the critical shortage of deceased donor grafts, clinicians are continually expanding the criteria for an acceptable liver donor to meet the waiting list demands. However, the reduced ischemic tolerance of those extended criteria grafts jeopardizes organ viability during cold storage. Machine perfusion has been developed to limit ischemic liver damage but despite its proven biochemical benefit, machine liver perfusion is not yet considered clinically due to its low practicability. In this review, we summarize our understanding of the role of machine perfusion in marginal liver preservation...
May 2008: American Journal of Transplantation
A P Navarro, S Sohrabi, H Wyrley-Birch, D Vijayanand, C Wilson, A Sanni, M Reddy, D Manas, D Rix, D Talbot
Kidneys transplanted from non-heart-beating donors (NHBD) are generally regarded as marginal or extended criteria grafts due to the associated period of warm ischemia. The most prolonged periods occurring in the category II (uncontrolled) donor. This potential for injury can adversely affect the glomular filtration rate (GFR), which in severe cases results in primary nonfunction. Viability testing can identify a group of kidneys that, although unsuitable for solitary transplantation, may be considered for dual transplant...
October 2006: Transplantation Proceedings
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